Allokin alfa substitute for injections. Allokin alfa: instructions for use, indications and analogues. Allokin alpha side effects

Lyophilizate for preparation of a solution for s / c administration in the form of a powder or porous mass, white, odorless; hygroscopic.

1 amp. contains: histidyl-glycyl-valyl-seryl-glycyl-histidyl-glycyl-glutaminyl-histidyl-glycyl-valyl-histidyl-glycine - 1 mg

Release form:

• 1 mg - ampoules (1) - blister packs (1) - cardboard packs.
• 1 mg - ampoules (1) - blister packs (2) - cardboard packs.
• 1 mg - ampoules (2) - blister packs (1) - cardboard packs.
• 1 mg - ampoules (2) - blister packs (2) - cardboard packs.
• 1 mg - ampoules (3) - blister packs (1) - cardboard packs.
• 1 mg - ampoules (3) - blister packs (2) - cardboard packs.
• 1 mg - ampoules (5) - blister packs (1) - cardboard packs.
• 1 mg - ampoules (5) - blister packs (2) - cardboard packs.
• 1 mg - ampoules (10) - blister packs (1) - cardboard packs.
• 1 mg - ampoules (10) - blister packs (2) - cardboard packs.

pharmachologic effect

Alloferon is an oligopeptide. The nature of the pharmacological action is most similar to interferon alpha. Alloferon is an effective inducer of the synthesis of endogenous interferons and an activator of the natural killer system, it is able to stimulate the disposition and lysis of defective cells by cytotoxic lymphocytes. The experiments demonstrated high efficiency against infections caused by influenza A and B viruses, hepatitis B and C, herpes types 1 and 2 and human papilloma. Alloferon does not have general toxicity, allergenic properties, mutagenic and carcinogenic effects, does not have an embryotoxic effect and does not affect reproductive function.

Pharmacokinetics

It quickly penetrates into the blood, where it interacts with immunocompetent cells, after which the determination of the concentration of Alloferon is difficult due to the close structural similarity of its metabolites with blood serum proteins. An increase in the concentration of interferon was observed 2 hours after the administration of the drug and remained at a high level (2-2.5 times higher than the usual background level) for 6-8 hours, reaching the initial values ​​by the end of the day. Increased functional activity of natural killers was observed within 7 days after drug administration.

Indications for use Allokin-alpha

• chronic recurrent herpes types 1 and 2;
• as part of complex therapy for moderate (icteric) forms of acute hepatitis B.

Contraindications to the use of Allokin-alpha

• severe autoimmune diseases;
• pregnancy;
• lactation period;
• childhood;
• hypersensitivity to the components of the drug.

Allokin-alpha Use during pregnancy and children

The drug is contraindicated during pregnancy and lactation

Contraindicated in childhood.

Allokin alpha side effects

In some cases, weakness, dizziness, the formation of new elements of the rash (with a herpes infection) are possible.

drug interaction

In the treatment of chronic recurrent genital herpes, it can be prescribed in combination with acyclovir and its derivatives (drugs have different mechanisms of action and complement each other in the treatment of viral infection).

In acute hepatitis B, the drug is prescribed against the background of generally accepted basic therapy.

Interaction with other drugs has not been identified.

Dosage of Allokin-alpha

The drug is administered s / c.

The standard course of treatment for herpes recurrence includes injections of the drug at a dose of 1 mg every other day, a total of 3 injections per course.

In moderate forms of acute hepatitis B, the drug is administered after verification of the diagnosis at a dose of 1 mg 3 times a week for 3 weeks (9 injections in total).

To prepare a solution for injection, use 1 ml of a 0.9% sodium chloride solution as a solvent.

Overdose

To date, cases of drug overdose have not been established.

Instructions for use of the drug Allokin-alpha claims that it is an effective tool for the treatment of human papillomavirus infection. The fact is that the drug is an excellent immunomodulatory and antiviral agent.

The medicine is produced in Russia (Moscow and St. Petersburg).

Composition and form of release

Release form of the drug: white powder or white mass for the preparation of a solution. The consistency is colorless and odorless.

The composition of the agent for 1 ampoule includes histidyl-glycyl-valyl-seryl-glycyl-histidyl-glycyl-glutaminyl-histidyl-glycyl-valyl-histidyl-glycine.

Important! Allokin-alpha will be sold only after a prescription is presented, which will be certified by the signature and seal of the attending physician.

Indications for use

Allokin-alfa injections are prescribed to treat conditions such as;

• papillomavirus infection (HPV or PVI);
• Genital herpes;
• Chronic form of hepatitis "B" and "C";
• Dysplasia of the uterus (erosion);
• labial herpes;
• herpetic infection;
• SARS, influenza;
• Warts, papillomas, condylomas.

Drug Interactions

It is necessary to take Allokin-Alfa with other immunomodulatory drugs with caution. It is necessary to regularly conduct a blood test if it is impossible to refuse to take one of the drugs.

Simultaneous reception of Allokin-Alpha with Acyclovir as part of complex therapy is not allowed, because. due to the different mechanism of action of both drugs, there is a mutual enhancement of antiviral efficacy.

Contraindications

In no case can Allokin-alfa injections be used in such cases as:

• Autoimmune diseases (scleroderma);
• Allergy to components;
• The patient's age is less than 18 years.

Side effects

The drug Allokin-alpha does not affect a person at the time of driving a car.

As a result of admission, the patient may experience such manifestations as:

• muscle weakness;
• The appearance of rashes, itching at the injection site;
• Dizziness or pain in the head.

These conditions occur with incorrectly formulated treatment. Such reactions can lead to conditions such as:

• Wrong combination of drugs;
• Exceeding the dosage of the drug;
• Failure to comply with contraindications;
• Violation of breaks between injections;
• Violation of body hygiene.

No data have been reported on the development of an overdose, but doctors do not exclude the risk of its occurrence. In the case of the introduction of the drug in large dosages, you should immediately call an ambulance for further advice.

Mode of application

The drug must be administered every two days.

The total dosage to be administered for conditions that are in progression is 6 injections. With a herpetic infection, which is at the stage of progression, Allokin-alpha is prescribed at a dosage of 1 mg.

The total dosage of Allokin-Alpha is 3 injections. For patients with acute hepatitis "B" of moderate severity, Allokin is prescribed 3 times a week.

Based on the patient's condition and the severity of the disease, after a while the doctor can decide on the advisability of re-administering the drug.

Allokin-alpha and alcohol

How to prick Allokin-alpha

The drug must be administered subcutaneously. The drug itself is painful, so you have to be patient.

To administer Allokin-alpha, it is necessary to collect the skin in a fold and insert a needle at an angle of 45 degrees into its base.

Photo instruction:

The drug Allokin-alpha is used to prepare a solution. To do this, the contents of the ampoules must be dissolved in 1 ml of isotonic sodium chloride solution. Do not use other drugs as a solvent. It is not recommended to mix other parenteral drugs in one syringe. It is recommended to apply the solution immediately after its preparation.

Video

Allokin-alpha for HPV

For lesions caused by oncogenic types of human papillomavirus, the administration of 1 mg of the drug every 48 hours is prescribed.

Allocoin-alpha during pregnancy

During pregnancy, you must stop taking this medication.

Substances included in the preparation may have a negative effect on the fetus.

During breastfeeding, the use of the drug is also not allowed. In case of non-compliance with the recommended requirements, the child begins to develop serious diseases that turn into a chronic stage. If it is not possible to replace the agent with a safe analogue, then the medication may be allowed, but this can solve it.

During menstruation, the use of the drug Allokin-alpha is allowed. If destruction is shown (on the 6-7th day of treatment), then therapy is started from the first day of the cycle. If the process of destruction is not observed, then treatment can be started on any of the days.

Storage conditions

Allokin-alpha medicine should be stored at a temperature of 2 to 8 degrees. The drug must be stored indoors, where in no case will the sun's rays fall. Do not give the drug into the hands of young children, because. if taken consciously, negative consequences can occur.

Price

When forming the cost of a drug, a number of factors are taken into account, which include the cost of transportation, which is borne by the company, the pharmacy mark-up, the purchase price, and the place of sale.

Important! For pricing information, please contact your nearest pharmacy.

For 3 ampoules of Allokin-alpha, on average, you will have to pay 3,750 rubles. For 6 ampoules, you need to pay 7890 rubles.

In Ukraine, 3 ampoules of Allcokin-alpha injections cost an average of 1667 UAH, the price for 6 ampoules is 3298 UAH.

Analogues

Among the Russian analogues of the drug Allokin-alpha, one can distinguish such drugs as:

A drug	Description
Gerpevir	This product is available in the form of capsules. They contain excellent substances, namely indole-3-carbinol, lecithin, lactose. You do not need to show a doctor's prescription to buy this drug. Yes, and at a price the tool is much lower than the original (1420 rubles).
Panavir	The agent is presented in the form of a solution for the preparation of injections, gel, rectal suppositories. The composition includes an excellent active substance, namely hexose glycoside. The onset of an overdose after taking the drug was not recorded. In order to purchase a product, there is no need to show a prescription from the attending physician. The cost of the drug is several times lower than the original (its price ranges from 1869 to 3750 rubles).

ALLOKIN-ALFA is a Russian-made antiviral drug. Quite an effective remedy, according to the manufacturer, in the treatment of herpes and HPV.

The main active substance of the drug is alloferon, which is essentially an analogue of human interferon.

Actions of the drug

In the body, the drug acts quite effectively, stimulating the production of a person's own interferon, stimulating the work of immune cells that kill the virus.

indications for the use of the drug:

After the injection, the effect of the drug still lasts 7 days. And this drug is released only by prescription. Among the indications for which it is recommended to use ALLOKIN-ALFA, and in which the drug has an effect:

human papilloma virus

Herpes virus type 1 and 2

Hepatitis B virus

flu virus

Instructions for use of the drug

Allokin alfa is available in ampoules and in powder form. They are not produced in tablets.

The powder in the ampoule is diluted with 1 ml of physical solution. This should be done immediately before the injection itself. Well, the injection itself is injected subcutaneously: into the shoulder or into the thigh.

Side effects of the drug

Almost all drugs, and even more so injections, have side effects. This drug is no exception. Among the side effects were weakness, dizziness, sometimes there is an increase in rash or allergy to Allokin. It is not recommended to combine with alcohol, as dizziness increases. But there is no pain at the injection site and is not felt. And in general, side effects with this injection are very rare.

But there are contraindications in which it is not recommended to use an injection:

autoimmune diseases

Children under 18

Pregnancy period

lactation period

ALLOKIN-ALFA drug is not cheap
. One injection ampule costs 1000 rubles, a pack in which at least 3 ampoules are sold and the price of such a package is 3500 rubles. There is also a package for 6 ampoules and the price is almost 7000 rubles.

There are a lot of analogues to the drug ALLOKIN-ALFA, both domestic (Russian and foreign). Among Russian analogues:

Panavir

Genferon in the form of candles

foreign:

Epigen intimate

Isoprinosine

Cream Aldara

Panavir is a Russian-made antiviral drug used to treat acute respiratory viral infections, herpes, HPV and other viral diseases. Among the indications for the use of drugs, it is worth noting: papillomas, herpes (on the lips and intimate), warts, genital warts.

Epigen is an antiviral drug of plant origin. Available in spray and gel form.

Isoprinosine (groprinosin) - immunostimulating and antiviral. but this analogue of ALLOKIN-ALFA is not imported to Russia.

For me, at first, the HPV disease sounded like a bolt from the blue. But my husband very quickly brought me back to reality and helped me to get ready. I was prescribed ALLOKIN-ALFA. I already wrote about the price of this drug, but you will have to be prepared for the fact that one package for three ampoules is not enough, because the treatment is not cheap, and often you need to purchase another package.

Ampoules should be stored only in the refrigerator and this should be taken very seriously.

I was vaccinated at the clinic. The injection technique is simple at first glance: you need to gather the skin into an accordion, and then insert the needle into the base of the fold at an angle of 45 degrees.

In general, the drug helps everyone in different ways. For example, the injection helped me the first time, because the disease was not started.

In general, I can not say anything bad. For me, this drug has become effective, but one minus - it's expensive!

Before use, be sure to consult a specialist

Name:

Allokin-Alfa (Allokin-Alfa)

Pharmacological
action:

Pharmacodynamics.
Alloferon is an oligopeptide. Alloferon is an effective inducer of the synthesis of endogenous α- and γ-interferons and an activator of the natural killer system.
The agent stimulates the recognition and lysis of defective cells by cytotoxic lymphocytes.
In the course of the studies, the drug was found to be highly effective against infections caused by influenza A and B viruses, hepatitis B, herpes types 1 and 2, and human papilloma (oncogenic types).
Alloferon does not cause general toxicity, allergic reactions, does not have mutagenic, carcinogenic and embryotoxic effects, does not affect reproductive function.

Pharmacokinetics.
It quickly penetrates into the blood, where it interacts with immunocompetent cells, after which the determination of the concentration of alloferon is difficult due to the close structural similarity of its metabolites with blood serum proteins.
An increase in the concentration of interferon was observed 2 hours after the administration of the drug and remained at a high level (2–2.5 times higher than the usual background level) for 6–8 hours, reaching the initial values ​​by the end of the day.
An increased functional activity of natural killers was noted within 7 days after the administration of the drug.

Indications for
application:

Allokin-Alpha is used for the treatment of patients suffering from chronic papillomavirus infection, which is associated with oncogenic types of human papillomavirus.
Alloferon can be used as monotherapy for human papillomavirus infection in the absence of clinical and subclinical lesions of the cervix and anogenital region, if such lesions are present, alloferon is recommended to be used in combination with other drugs.

Allokin-Alpha is prescribed in the complex therapy of chronic recurrent herpes of the second and first types(in this case, therapy should be started as soon as possible after the onset of the first symptoms).
Alloferon in combination with other drugs is used in the treatment of patients with acute hepatitis B of moderate severity (therapy with Allokin-Alpha should be started no later than the seventh day after the onset of jaundice).

Mode of application:

Allokin-Alpha drug intended for preparation of a solution for subcutaneous administration.
To prepare the solution, the contents of the ampoule should be dissolved in 1 ml of isotonic sodium chloride solution.
It is not recommended to use other drugs as a solvent.
Allokin-Alpha must not be mixed with one syringe with other parenteral preparations. Allokin-Alpha solution should be used immediately after preparation. The duration of therapy and the scheme of application of alloferon is determined by the doctor.
In infections caused by oncogenic types of human papillomavirus, as a rule, the administration of 1 mg of alloferon is prescribed every 48 hours.
The total recommended course dose of Allokin-Alpha is 6 injections.

For recurrent herpes infection, as a rule, during an exacerbation, the administration of 1 mg of alloferon is prescribed every 48 hours.
The total recommended course dose of Allokin-Alpha is 3 injections.

Patients with acute hepatitis B of moderate severity, as a rule, after verification of the diagnosis, the administration of 1 mg of alloferon three times a week is prescribed.
The total recommended course dose of Allokin-Alpha is 9 injections.
Depending on the patient's condition and the effectiveness of the therapy, after some time the doctor may prescribe a second course of Allokin-Alpha.

Side effects:

Perhaps: weakness, dizziness, the formation of new elements of a herpetic rash.

Contraindications:

Pregnancy;
- lactation period;
- age up to 18 years;
- do not prescribe to patients with individual intolerance to alloferon;
- do not use for the treatment of patients suffering from severe autoimmune diseases;
- in pediatric practice, the use of alloferon is not recommended;
- if patients develop dizziness during alloferon therapy, activities that require increased concentration of attention should be excluded.

Interaction
other medicinal
by other means:

In the treatment of chronic recurrent genital herpes, it can be prescribed in combination with acyclovir and its derivatives (drugs have different mechanisms of action and complement each other in the treatment of a viral infection).
In acute hepatitis B, the drug is prescribed against the background of generally accepted basic therapy.
Interactions with other drugs have not been identified.

Total analogues: 37. Price and availability of ALLOKIN-ALFA analogues in pharmacies. Before using any medication, you should definitely consult your doctor.

This page provides a list analogues ALLOKIN-ALFA- these are interchangeable drugs that have similar indications for use and belong to the same pharmacological group. Before you buy analogue of ALLOKIN-ALFA, it is necessary to consult with a specialist regarding the replacement of the drug, study in detail, read and a similar drug.

• Valtrex

  A drug Valtrex intended as a treatment for herpes zoster;
  Treatment of diseases of the skin and mucous membranes caused by the Herpes simplex virus types 1 and 2 (including newly diagnosed and recurrent genital herpes);
  Prevention of recurrence of diseases of the skin and mucous membranes caused by the Herpes simplex virus types 1 and 2 (including genital herpes);
  Prevention of cytomegalovirus infection and diseases developing after organ transplantation. Prevention with Valtrexa reduces the transplant rejection reaction, the development of infections caused by opportunistic microorganisms, and other viral infections (including herpes zoster).

• Famciclovir

  Famciclovir prescribed for the treatment of herpes zoster, postherpetic neuralgia, recurrent genital herpes.
  

• Zovirax

  Zovirax prescribed for the following diseases:
  - treatment of infections caused by the Herpes simplex virus type 1 and 2;
  - prevention of infections caused by the Herpes simplex virus type 1 and 2 in patients with immunodeficiency;
  - treatment of infections caused by the Varicella zoster virus (chicken pox and herpes zoster);
  - treatment of infections caused by the Herpes simplex virus type 1 and 2 in newborns;
  - prevention of cytomegalovirus infection in bone marrow transplant recipients.
  Eye ointment:
  - Treatment of keratitis caused by Herpes simplex virus types 1 and 2.

• Tamiflu

  Tamiflu is used to treat influenza caused by viruses types A and B in adults and children over the age of 1 year.
  Typical flu symptoms come on suddenly and include fever, cough, headache, severe weakness, muscle aches, and sore throat.
  Prevention of influenza in adults and adolescents over the age of 12 who are at high risk of infection with the virus (in military units and large production teams, in debilitated patients).
  

• Novirin

  Novirin are:
  - Infectious diseases of viral etiology in patients with normal and reduced immune status: influenza, parainfluenza, acute respiratory viral infections, bronchitis of viral etiology, rhinovirus and adenovirus infections; mumps, measles;
  - Diseases caused by herpes simplex viruses Herpes simplex type I or II (herpes of the lips, facial skin, oral mucosa, skin of the hands, ophthalmic herpes), subacute sclerosing panencephalitis, genital herpes with the Varicella zoster virus (chicken pox and shingles, including recurrent in patients with immunodeficiency); Epstein-Barr virus (infectious mononucleosis) cytomegalovirus; human papillomavirus; acute and chronic viral hepatitis B;
  - Chronic recurrent infections of the respiratory tract and genitourinary system in immunocompromised patients (chlamydia and other diseases caused by intracellular pathogens).
  

• Ganciclovir

  A drug Ganciclovir applies:
  - For the treatment of life-threatening or vision-threatening overt CMV infection in individuals with immunodeficiencies, including AIDS, iatrogenic immunodeficiency associated with organ transplantation or neoplastic chemotherapy.
  - In order to prevent overt CMV infection in patients receiving immunosuppressive therapy after organ transplantation.
  

• NORMOMED

• LAMIVUDINE

• MIOMIN

• HEPSERA

• DUCKLINZA

• SOVALDI

• SOPHOSBUVIR

• ATRIPLA

• KOMBIVIR

• STOKRIN

• TENVIR EM

• EDURANT

• MAVIRET

• Uviromed

  A drug Uviromed it is applied for:
  - treatment of herpes zoster;
  - treatment and prevention of recurrence of infections of the skin and mucous membranes caused by the herpes simplex virus (including newly diagnosed and recurrent genital herpes);
  - treatment of labial herpes;
  - reducing the risk of infection with genital herpes in a healthy partner, if taken as a suppressive therapy in combination with safe sex;
  - prevention of cytomegalovirus infection that occurs during organ transplantation (reduces the severity of acute transplant rejection in patients with kidney transplants, the development of opportunistic infections and other viral infections caused by Herpes simplex and Varicella zoster viruses) in adults and children over 12 years of age.
  

• Sofosvel

  A drug Sofosvel is indicated for the treatment of adults with chronic hepatitis C genotypes 1, 2, 3, 4, and 6, as well as patients with compensated or decompensated liver cirrhosis.

• Valmax

  Indications for the use of the drug Valmax are:
  - Treatment of herpes zoster (Herpes zoster).
  - Treatment of infections of the skin and mucous membranes caused by the herpes simplex virus, including primary and recurrent genital herpes.
  - Treatment of labial herpes (labial fever).
  - Preventive treatment (suppression) of recurrent infections of the skin and mucous membranes caused by the herpes simplex virus, including genital herpes.
  - Reducing the transmission of the genital herpes virus to a healthy partner when using Valmax as a suppressive therapy in combination with safe sex.
  - Prevention of cytomegalovirus infection and disease after organ transplantation.
  

• Viread

  Viread it is applied for:
  - Treatment of HIV-1 infection in adults in combination with other antiretrovirals and drugs.
  - Treatment of HIV-1 infection in children aged 12 to 18 years with resistance to non-nucleoside reverse transcriptase inhibitors, or toxicity precluding the use of first-line antiretrovirals.
  A drug Viread used in the treatment of hepatitis B:
  Treatment of chronic hepatitis B in adults with:
  - compensated liver disease, signs of active viral replication, persistent elevated serum alanine aminotransferase (ALT) activity and histologically confirmed active inflammatory process and / or fibrosis;
  - proven HBV resistance to clamivudine;
  - decompiled liver disease.
  Treatment of chronic hepatitis B in children aged 12 to 18 years with
  - compensated liver disease with signs of an active inflammatory process and active virus replication, as evidenced by persistent elevated serum ALT activity and histologically confirmed active inflammatory process and/or fibrosis.
  

• Sebivo

  A drug Sebivo is used to treat chronic hepatitis B in adult patients with confirmed viral replication and an active inflammatory process in the liver.
  

• Vacirex

  A drug Vacirex used to treat in adults: herpes zoster; diseases of the skin and mucous membranes caused by the Herpes simplex virus (including genital herpes); prevention of recurrence of diseases caused by the Herpes simplex virus.
  In adults and children from 12 years of age: prevention of cytomegalovirus infection during organ transplantation.