Amosin 125 instructions for use for children. Review: the use of the antibiotic Amosin for the treatment of children. What it is

Amosin - modern, popular antibiotic. It fights bacterial infections and is effective against streptococcus, salmonella, listeria, anthrax, helicobacter pylori. The drug belongs to the group of semi-synthetic penicillins. His can be given to children from birth.

Amosin is a broad-spectrum antibiotic.

Action

The main active ingredient of the drug is amoxicillin.

It prevents the synthesis of substances that make up the cell membranes of pathogenic microorganisms. This leads to the death of bacteria. The active components of Amosin penetrate the body and begin to act already 15 minutes after ingestion.

Release form, prices and manufacturers

The drug is available in different forms, so it can be used to treat children of any age.

• Capsules- white gelatin (250 mg, 20 pieces per pack) - 60 rubles.
• Pills- semi-cylindrical + 5 white color with an active ingredient content of 250 mg or 500 mg. Price 250 mg (blister 10 pieces) - 25 rubles; 500 mg (blister 10 pieces) - 60 rubles.

Tablets are used only for the treatment of children older than 5 years.

• Powder for suspension preparation- yellowish with a specific smell is available in dosages: 125 mg, 250 mg, 500 mg (10 sachets each) - 40, 55, 85 rubles. respectively.

Amosin is a domestically produced drug produced by the pharmaceutical company Sintez AKO JSC. The medicine is sold without a prescription.

Indications for use

The drug is prescribed for infections caused by pathogenic microorganisms, if they are sensitive to the antibiotic. Amosin is used for:

• pathologies of the respiratory system;
• diseases of ENT organs;
• diseases of the urinary organs;

Urinary tract infection is one of the most common diseases in children.

• skin infections;
• endocarditis;
• endometritis;
• enterocolitis, peritonitis;
• meningitis;
• listeriosis;
• dysentery and other diseases.

The drug is absorbed from the digestive organs, spreads with blood throughout the body.

The medicine is effective for eight hours after ingestion.

Method of application and dosage

It is most convenient for children to give Amosin in the form of a suspension. To prepare it, you need to pour the contents of the sachet into a glass of boiled chilled water (if the content of the active substance is 125 mg, then the powder is diluted in 2.5 ml of liquid, 250 mg - 5 ml and 500 mg - 10 ml, respectively), stir.

The dosage is determined by the attending physician and depends on the severity and nature of the disease.

The dosage of the drug is set individually in each case. The instruction recommends the following scheme for taking Amosin suspension:

• Children over 10 years old- Three times a day, 500 mg.
• Patients aged 5 to 10 years - three times a day, 250 mg.
• 2 to 5 years- 125 mg three times a day.
• Dose for babies under 2 years old calculated as follows: 20 mg per kilogram of the child's weight. This dose is divided into three doses per day.

Children over 5 years of age can be given the drug in the form of tablets, capsules or suspensions.

Capsules must be swallowed without chewing, before or after meals.

A newborn and a child under 5 years old - only in the form of a liquid.

Accurate adherence to the dosage will avoid unpleasant side effects.

Side effects

Amosin is a strong antibiotic, and sometimes it causes side reactions. In such cases, it is replaced by softer counterparts.

The drug can cause the development of side effects from:

• gastrointestinal tract - indigestion, nausea;

The drug may cause abdominal pain and nausea.

• CNS - overexcitation, sleep disturbance, anxiety, tearfulness;
• respiratory organs - shortness of breath;
• allergies - itching, rash, nasal congestion,.

In some cases, in children, as a result of taking the drug, the liver slightly increased in size. Rarely, but still, adverse reactions from the cardiovascular system (tachycardia) can occur.

If after taking Amosin the baby has any reactions, inform your doctor.

Usually, during and after antibiotic therapy, parents give their children drugs that help restore normal intestinal microflora. We will talk about how to restore a child's body after taking antibiotics.

Contraindications

The use of Amosin for the treatment of children is not always possible. The drug has a number of contraindications. Read the instructions beforehand or consult your doctor. The medicine should not be given to children with:

• diseases of the digestive tract;
• problems in the liver, kidneys;
• mononucleosis of infectious origin;
• bronchial asthma.

Patients with bronchial asthma medicine is contraindicated.

The drug in the form of tablets and capsules is contraindicated in children under the age of five years. in such cases, only Amosin suspension can be given.

Overdose

Cases of overdose are known, but there is no specific antidote (an agent that binds and removes the components of a drug from the body) to Amosin. Patients may experience symptoms such as nausea, diarrhea,.

In such cases, you should immediately call an ambulance. In case of an overdose of an antibiotic, the child's stomach is washed, laxatives and enterosorbent drugs are prescribed.

Amosin's analogs

On sale there are analogues of the drug Amosin, they are also prescribed for babies with infectious diseases. Below is a brief overview of the most popular of these medicines. The active substance of these drugs is also amoxicillin:

• (manufacturer Astellas Pharma, the Netherlands), - release form - tablets (average price - 300 rubles for 20 tablets of 250 mg); prescribed for infections of the respiratory tract, genitourinary organs, skin. For children under one year old, the drug is given in doses not exceeding 60 mg per kilogram of body weight per day.

Amosin's analogue is Flemoxin Solutab.

• (manufacturer Lek, Slovenia) - sold in the form of tablets (230 rubles for 14 pieces) and powder for suspension (120 rubles). Give the drug to children from birth. Patients under the age of three months are prescribed 30 mg per kilogram of body weight per day.
• (manufacturer GlaxoSmithKline Export, UK) - available in the form of a powder for suspension (average price - 145 rubles per bottle) and tablets (260 rubles for 20 pcs.); a modern antibiotic, often prescribed to children by doctors of various profiles.

Among other well-known analogues in composition and mechanism of action, Danemox, Amoxon.

In this article, you can read the instructions for using the drug Amosin. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of the Amosin antibiotic in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Amosin in the presence of existing structural analogues. Use for the treatment of tonsillitis, pneumonia, sinusitis and other infectious diseases in adults, children, as well as during pregnancy and lactation. The composition and interaction of the drug with alcohol.

Amosin- a broad-spectrum antibiotic of a group of semi-synthetic penicillins. Acts bactericidal. It inhibits transpeptidase, disrupts the synthesis of peptidoglycan (the supporting polymer of the cell wall) during division and growth, and causes bacterial lysis. Acid resistant.

Active against aerobic Gram-positive bacteria: Staphylococcus spp. (staphylococcus aureus) (with the exception of strains producing penicillinase), Streptococcus spp. (streptococcus); aerobic Gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Bacillus anthracis, Listeria monocytogenes (Listeria), Helicobacter pylori (Helicobacter), Klebsiella spp. (Klebsiella).

Microorganisms producing penicillinase are resistant to the action of amoxicillin.

The action develops 15-30 minutes after administration and lasts 8 hours.

Compound

Amoxicillin (in the form of trihydrate) + excipients.

Pharmacokinetics

After oral administration, Amosin is rapidly and almost completely (93%) absorbed from the gastrointestinal tract. Eating does not affect the absorption of the drug, is not destroyed in the acidic environment of the stomach. It is found in high concentrations in plasma, sputum, bronchial secretions (poor distribution in purulent bronchial secretions), pleural and peritoneal fluid, urine, contents of skin blisters, lung tissue, intestinal mucosa, female genital organs, prostate gland, middle ear fluid, bones , adipose tissue, gallbladder (with normal liver function), fetal tissues. When the dose is increased by 2 times, the concentration also increases by 2 times. The concentration in bile exceeds the concentration in plasma by 2-4 times. In the amniotic fluid and vessels of the umbilical cord, the concentration of amoxicillin is 25-30% of the plasma level in a pregnant woman. Poorly penetrates the blood-brain barrier (BBB), with inflammation of the meninges (meningitis), the concentration in the cerebrospinal fluid is about 20%. Plasma protein binding - 17%. A small amount is excreted in breast milk. Amoxicillin is partially metabolized to inactive metabolites. Amoxicillin is excreted by 50-70% in the urine unchanged by tubular excretion (80%) and glomerular filtration (20%), with bile - 10-20%.

Indications

Infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

• respiratory infections (including bronchitis, pneumonia);
• infections of ENT organs (including sinusitis, pharyngitis, tonsillitis, acute otitis media);
• infections of the genitourinary system (including pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea);
• gynecological infections (including endometritis, cervicitis);
• infections of the digestive tract (including peritonitis, enterocolitis, typhoid fever, cholangitis, cholecystitis);
• infections of the skin and soft tissues (including erysipelas, impetigo, secondarily infected dermatoses);
• leptospirosis;
• listeriosis;
• Lyme disease (borreliosis);
• dysentery;
• salmonellosis, salmonellosis;
• meningitis;
• endocarditis (prevention);
• sepsis.

Release form

Capsules 250 mg.

Tablets 250 mg and 500 mg.

Powder for suspension for oral administration 125 mg, 250 mg and 500 mg.

Instructions for use and dosage

The drug is taken orally, before or after a meal. The dosage regimen is set individually, taking into account the severity of the course of the disease, the sensitivity of the pathogen to the drug, the age of the patient.

Adults and children over 10 years old (weighing more than 40 kg) are prescribed 500 mg 3 times a day, in severe cases of the disease - 0.75-1 g 3 times a day.

Children aged 5 to 10 years are prescribed 250 mg 3 times a day, aged 2 to 5 years - 125 mg 3 times a day, under the age of 2 years - 20 mg / kg per day in 3 divided doses. The course of treatment is 5-12 days.

For children under the age of 5 years, the drug is prescribed in the form of a suspension (ideal children's form of the drug).

For the treatment of acute uncomplicated gonorrhea, the drug is prescribed at a dose of 3 g once; in the treatment of women, repeated administration of the indicated dose is recommended.

In acute infectious diseases of the gastrointestinal tract (paratyphoid, typhoid fever) and biliary tract, with gynecological infectious diseases, adults are prescribed 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

With leptospirosis, adults are prescribed 500-750 mg 4 times a day for 6-12 days.

With salmonella carriage in adults - 1.5-2 g 3 times a day for 2-4 weeks.

For the prevention of endocarditis in minor surgical interventions, adults are prescribed at a dose of 3-4 g 1 hour before the procedure. If necessary, a second dose is prescribed after 8-9 hours. In children, the dose is halved.

Rules for preparing a suspension from a single-dose package

Boiled and cooled water is poured into a clean glass in the amount indicated in the table, then the contents of one package are poured out and mixed until a homogeneous suspension is obtained.

• The dose in the package is 125 mg - the required amount of water is 2.5 ml;
• dose in a package of 250 mg - the required amount of water is 5 ml;
• the dose in the package is 500 mg - the required amount of water is 10 ml.

After taking the glass, rinse with water, dry and store in a dry, clean place.

Side effect

• hives;
• skin hyperemia;
• erythema;
• angioedema;
• rhinitis;
• conjunctivitis;
• fever;
• pain in the joints;
• eosinophilia;
• exfoliative dermatitis;
• multiform exudative erythema;
• Stevens-Johnson syndrome;
• reactions similar to serum sickness;
• anaphylactic shock;
• dysbacteriosis;
• taste change;
• vomiting, nausea;
• diarrhea;
• stomatitis;
• glossitis;
• pseudomembranous enterocolitis;
• excitation;
• anxiety;
• insomnia;
• confusion;
• behavior change;
• depression;
• peripheral neuropathy;
• headache;
• dizziness;
• convulsive reactions;
• interstitial nephritis;
• leukopenia, neutropenia, thrombocytopenic purpura, anemia;
• labored breathing;
• tachycardia;
• vaginal candidiasis;
• superinfection (especially in patients with chronic diseases or reduced body resistance).

Contraindications

• allergic diathesis;
• bronchial asthma, hay fever;
• Infectious mononucleosis;
• lymphocytic leukemia;
• liver failure;
• a history of gastrointestinal disease (especially colitis associated with the use of antibiotics);
• lactation period (breastfeeding);
• hypersensitivity to the components of the drug;
• hypersensitivity to other penicillins, cephalosporins, carbapenems;
• children's age up to 3 years (for tablets and capsules).

Use during pregnancy and lactation

The use of the drug during pregnancy is possible only in cases where the intended benefit of therapy for the mother outweighs the potential risk to the fetus.

Use during lactation is contraindicated. If necessary, use during lactation should stop breastfeeding.

Use in children

Contraindicated in children under the age of 3 years (for the release form in the form of tablets and capsules). For children under the age of 5 years, the drug is prescribed in the form of a suspension.

special instructions

When conducting a course of treatment with Amosin, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys.

Perhaps the development of superinfection due to the growth of microflora insensitive to amoxicillin, which requires a corresponding change in antibiotic therapy.

When treating patients with bacteremia, a bacteriolysis reaction rarely develops (the Jarisch-Herxheimer reaction).

In patients with hypersensitivity to penicillins, cross-allergic reactions with cephalosporin antibiotics are possible.

In the treatment of mild diarrhea against the background of the use of Amosin, the appointment of antidiarrheal drugs that reduce intestinal motility should be avoided; kaolin- or attapulgite-containing antidiarrheals may be used. In severe diarrhea, it is necessary to conduct a differential diagnosis and prescribe appropriate therapy.

Treatment should be continued for another 48-72 hours after the disappearance of clinical signs of the disease.

With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, additional methods of contraception should be used, if possible.

drug interaction

Antacids, glucosamine, laxatives, food, antibiotics of the aminoglycoside group, while used simultaneously, slow down and reduce the absorption of Amosin; ascorbic acid - increases its absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) show synergism with amoxicillin; bacteriostatic drugs (macrolides, chloramphenicol, lincosamines, tetracyclines, sulfonamides) - antagonism.

Amoxicillin, with simultaneous use, increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); reduces the effectiveness of estrogen-containing oral contraceptives, ethinyl estradiol (the risk of intermenstrual bleeding), as well as drugs, during the metabolism of which para-aminobenzoic acid is formed.

The joint use of the drug Amosin with alcohol is prohibited (the hepatotoxic effect of ethanol is enhanced).

Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, non-steroidal anti-inflammatory drugs (NSAIDs) and drugs that block tubular secretion, while used with Amosin, reduce tubular secretion, increase the concentration of amoxicillin.

With the simultaneous use of Amosin with allopurinol, the risk of developing a skin rash increases.

Amoxicillin with simultaneous use reduces clearance and increases the toxicity of methotrexate.

Amoxicillin with simultaneous use enhances the absorption of digoxin.

Analogues of the drug Amosin

Structural analogues for the active substance:

• Amoxisar;
• Amoxicillin;
• Amoxicillin trihydrate;
• Gonoform;
• Grunamox;
• Danemox;
• Ospamox;
• Flemoxin Solutab;
• Hyconcil;
• Ecoball.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Amosin is a semi-synthetic drug from the group of penicillins with broad spectrum antibacterial action.

Its effect is manifested in the inhibition of the transpeptidase enzyme, in the violation of the stability of the cell walls, inhibition of the development of pathogenic microorganisms and their division at the cellular level, which ultimately causes the lysis of the pathogenic microflora.

On this page you will find all the information about Amosin: full instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Amosin. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

An antibiotic of the penicillin group of a wide spectrum of activity, which is destroyed by penicillinase.

Terms of dispensing from pharmacies

Released by prescription.

Prices

How much does Amosin cost? The average price in pharmacies is at the level of 30 rubles.

Release form and composition

Amosin is available in several dosage forms.

Amosin gelatin capsules, white, size 0. The contents of the capsules are white granules. Packed in contour cells of 10 pieces.

Amosin tablets are white or almost white in color, flat cylindrical in shape, with a separating risk and a chamfer. Packed in contour cells of 10 pieces.

Amosin powder for suspension for oral administration - has a white color with a yellowish tinge and a specific smell. The prepared suspension is white with a yellowish tint and a specific smell. Packed in single-dose packages of 1.5; 3 and 6 years

Pharmacological effect

The active component of the therapeutic agent actively affects gram-negative bacteria - Neisseria meningitidis and Listeria monocytogenes and Bacillus anthracis, Klebsiella spp., Neisseria gonorrhoeae and Helicobacter pylori; for gram-positive staphylococcal and streptococcal bacteria. The pathogenic microflora that produces penicillinase is immune to the effects of the active component of Amosin.

The effect of taking the therapeutic drug appears at 15-30 minutes and lasts 8 hours. The drug is easily and within a short time absorbed by the walls of the gastrointestinal tract, and the presence of food in it does not affect the rate of absorption. The maximum content of amoxicillin is reached in the blood plasma in the first 1-2 hours. The blood flow brings the active ingredient of the drug to the mucous organs, bone and connective tissue, intraocular sputum and fluid. The time of excretion of the drug through the kidneys averages from two to three hours and may increase in patients with impaired renal function.

Indications for use

The antibiotic Amosin is prescribed for bacterial infections:

• Urogenital infections (, pyelitis,);
• Infectious diseases of the digestive tract (dysentery, abdominal type,);
• Borreliosis;
• Acute infectious diseases of the upper respiratory tract;
• Acute infectious diseases of the lower respiratory tract (,);
• Infections of ENT organs (,);
• Diseases of the skin and soft tissues (secondary infected dermatosis, impetigo,);
• Prevention of endocarditis and surgical infection.

Contraindications

Contraindications to the use of Amosin are:

• Liver failure;
• Bronchial asthma and hay fever;
• Allergic diathesis;
• lymphocytic leukemia;
• Infectious mononucleosis;
• Diseases of the gastrointestinal tract;
• Hypersensitivity to amoxicillin and other penicillins, as well as carbapenems and cephalosporins;
• The period of breastfeeding;
• Children's age up to 3 years (for the dosage form in the form of capsules and tablets).

With caution, Amosin is prescribed to pregnant women and patients with renal insufficiency and a history of bleeding.

Use during pregnancy and lactation

The use of the drug during pregnancy is possible only in cases where the intended benefit of therapy for the mother outweighs the potential risk to the fetus.

Use during lactation is contraindicated. If necessary, use during lactation should stop breastfeeding.

Instructions for use Amosin

The instructions for use indicate that Amosin is taken orally, before or after a meal. The dosage regimen is set individually, taking into account the severity of the course of the disease, the sensitivity of the pathogen to the drug, the age of the patient.

• Adults and children over 10 years old (weighing >40 kg) are prescribed 500 mg 3 times / day, in severe cases of the disease - 0.75-1 g 3 times / day.
• Children aged 5 to 10 years are prescribed 250 mg 3 times / day, aged 2 to 5 years - 125 mg 3 times / day, under the age of 2 years - 20 mg / kg / day in 3 divided doses. The course of treatment is 5-12 days.
• For children under the age of 5 years, the drug is prescribed in the form of a suspension.

For treatment of acute uncomplicated gonorrhea the drug is prescribed in a dose of 3 g once; in the treatment of women, repeated administration of the indicated dose is recommended.

At acute infectious diseases of the gastrointestinal tract (paratyphoid, typhoid fever) and biliary tract, with gynecological infectious diseases adults are prescribed 1.5-2 g 3 times / day or 1-1.5 g 4 times / day.

At leptospirosis adults are prescribed 500-750 mg 4 times / day for 6-12 days.

At salmonella carrier adults - 1.5-2 g 3 times / day for 2-4 weeks.

For prevention of endocarditis in minor surgical interventions adults are prescribed at a dose of 3-4 g 1 hour before the procedure. If necessary, a second dose is prescribed after 8-9 hours. In children, the dose is halved.

In patients with impaired renal function (CC from 15 to 40 ml / min), the interval between doses is increased to 12 hours, in the terminal stage of chronic renal failure (CC<10 мл/мин) дозу Амосина следует уменьшить на 15-50% или увеличить интервал между приемами до 24 ч, при анурии – максимальная доза составляет 2 г/сут.

Powder for oral suspension Amosin

The drug is intended for the preparation of a suspension taken orally. The finished suspension is taken before or after a meal.

To prepare a suspension from a powder packaged in disposable bags, pour chilled boiled water into a glass, pour the contents of the bag and stir until an equilibrium suspension is obtained. The amount of water is measured depending on the dose of amoxicillin in the package (to obtain a suspension containing 250 mg of amoxicillin in 5 ml of suspension). At a dose of amoxicillin in a 125 mg sachet, take 2.5 ml of drinking water, at a dose of 250 mg - 5 ml of drinking water, at a dose of 500 mg - 10 ml of drinking water. The drug should be taken immediately after preparing the suspension. The glass after taking the drug should be washed in running water and dried.

To prepare a suspension from a powder packaged in jars or vials, measure out 62 ml of chilled boiled water and add parts to the vial or jar. While adding water, shake the jar or bottle to form an equilibrium suspension. The finished suspension contains 50 mg of amoxicillin in 1 ml. Shake the vial before each use of the suspension. Dosing of the suspension is carried out using a measuring spoon included in the kit.

The duration of use and dose of the drug Amosin is determined by the doctor.

• Adults and children weighing more than 40 kg (over 10 years old) are usually prescribed 500 mg of amoxicillin three times a day. In severe cases of the disease, the dose is increased to 750-1000 mg of amoxicillin three times a day.
• Children aged 5 to 10 years are usually prescribed 250 mg of amoxicillin three times a day.
• Children aged 2 to 5 years are usually prescribed 125 mg of amoxicillin three times a day.
• Children under 2 years of age are usually prescribed 20 mg of amoxicillin per 1 kg of body weight three times a day.
• The average duration of therapy is from 5 to 12 days (as a rule, the drug is continued for 2-3 days after the disappearance of the clinical manifestations of the disease).

Specific schemes of therapy with Amosin:

In the acute form of uncomplicated gonorrhea, adults are usually prescribed a single dose of 3000 mg of amoxicillin. Women may be given a repeat dose of the recommended dose of amoxicillin.

1. In acute infectious diseases of the biliary tract and gastrointestinal tract, as well as gynecological diseases, adults are usually prescribed 1500-2000 mg of amoxicillin three times a day or 1000-1500 mg of amoxicillin four times a day.
2. For leptospirosis, adults are usually prescribed 500-750 mg of amoxicillin four times a day. The duration of the drug Amosin is from 6 to 12 days.
3. With salmonella carriers, adults are usually prescribed 1500-2000 mg of amoxicillin three times a day. The duration of taking the drug Amosin is 2-4 weeks.
4. For the prevention of endocarditis during minor surgical operations, adults are usually prescribed 3000-4000 mg of amoxicillin 60 minutes before the start of surgery. At a high risk of developing endocarditis, a second dose of amoxicillin is prescribed 8-9 hours after taking the first dose. Children are advised to reduce prophylactic doses of amoxicillin by half.

In case of impaired renal function and creatinine clearance rates from 15 to 40 ml / min, it is recommended to increase the interval between doses of amoxicillin to 12 hours (while the single dose of Amosin is not changed).

In case of impaired renal function and creatinine clearance less than 10 ml / min, the dose of amoxicillin should be reduced by 15-50%.

With prolonged use of amoxicillin, it is recommended to monitor the function of the hematopoietic system, liver and kidneys.

Side effects

According to the instructions for Amosin, taking the drug can cause the following undesirable effects:

• From the urinary system - interstitial nephritis;
• From the side of the central and peripheral nervous system - anxiety, agitation, ataxia, insomnia, behavioral changes, confusion, peripheral neuropathy, convulsive reactions, dizziness, headache;
• On the part of the digestive system - a change in taste, nausea, vomiting, dysbacteriosis, diarrhea, glossitis, stomatitis, impaired liver function, pseudomembranous enterocolitis;
• Allergic reactions - skin flushing, urticaria, erythema, rhinitis, angioedema, conjunctivitis, joint pain, fever, exfoliative dermatitis, eosinophilia, Stevens-Johnson syndrome, erythema multiforme, reactions similar to serum sickness, in isolated cases - anaphylactic shock;
• On the part of the hematopoietic system - neutropenia, leukopenia, anemia, thrombocytopenic purpura.

In addition, the use of Amosin can cause tachycardia, superinfection, shortness of breath and vaginal candidiasis.

Overdose

It is necessary to correctly understand what Amosin helps with, and in what cases it harms. Of course, an overdose of the drug is unpleasant and dangerous to health. In the case of taking high doses of the drug, patients may develop vomiting, nausea, diarrhea, pain in the epigastric region, and possibly a violation of the water and electrolyte balance.

In case of an overdose, the patient should wash the stomach and prescribe enterosorbent agents. If overdose symptoms develop, symptomatic therapy should be prescribed. It would also be advisable to prescribe saline laxatives, as well as conduct procedures that maintain water and electrolyte balance.

special instructions

When using Amosin, it is necessary to monitor the state of the function of the kidneys, liver and hematopoietic organs.

1. During treatment with the drug, superinfection may develop, which requires a change in antibiotic therapy.
2. In patients with bacteremia, the Jarisch-Herxheimer reaction (bacteriolysis reaction) may occur, manifested by fever, chills, nausea, headache, tachycardia, lowering blood pressure and aggravation of the symptoms of the underlying disease.
3. With increased sensitivity to penicillins, the use of Amosin can cause cross-allergic reactions with cephalosporin antibiotics.
4. With the simultaneous use of amoxicillin and oral contraceptives containing estrogen, it is recommended to use additional methods of protection against unwanted pregnancy.
5. If mild diarrhea occurs during treatment with Amosin, drugs that reduce intestinal motility should be avoided. For this, attapulgite- or koalin-containing antidiarrheals can be used. Severe diarrhea requires differential diagnosis and appropriate treatment.

drug interaction

1. Drugs that block tubular secretion cause an increase in the concentration of amokicillin, while the use of Methotrexate increases the toxicity of the latter.
2. With the simultaneous use of amoxicillin with glucosamines, aminoglycosides, laxatives and antacids, delayed absorption is noted, when taken together with ascorbic acid, metabolism increases.
3. With simultaneous use with Metronidazole often develops nausea, vomiting, diarrhea, pain in the epigastric region.
4. In combination with clavulanic acid, cholestatic jaundice, hepatitis, and erythema multiforme may develop.
5. Interaction with Probenecid increases the serum concentration of the antibiotic and reduces its excretion from the body. Amosin, like other antibacterial drugs, reduces the effectiveness of oral contraceptives.
6. Amosin synergists are cephalosporins, aminoglycosides, rifampicin, vancomycin, cycloserine, antagonists are sulfonamides, macrolides, tetracyclines and lincosamides.

Simultaneous use with disulfiram is strictly contraindicated. Special care should be taken when using amoxicillin and anticoagulants at the same time (this may cause prolongation of the prothrombin time.

When a child is very ill, only a competent doctor can help. With luck, the child will get off with several doses of antiviral drugs. If the doctor has even the slightest concern about possible complications, most likely, he will prescribe an antibiotic.

Recently, according to the Ministry of Health, seasonal "sores" mutate and are more severe, especially in children aged 2-3 years. It was at this time that kids begin to attend kindergarten, actively explore the world, and contact with peers. And there is a fertile soil for the mutual exchange of bacteria. As a result, mom has to go on sick leave with enviable regularity.

What diseases lie in wait most often for a small person? Local pediatricians know the answer to this question for sure. The most common among children in winter and in the off-season are bronchitis, tonsillitis, pharyngitis, various forms of otitis, tonsillitis. If a child rolls on an ice slide or skating rink, another nuisance can happen - hypothermia often causes inflammation of the genitourinary system. The doctor's conclusion then sounds different - cystitis, pyelonephritis. Often, babies suffer from intestinal diseases (they are usually "brought" from the kindergarten). There is an exit. In all these unpleasant cases, the modern broad-spectrum antibiotic Amosin effectively helps.

What it is?

Let's try to explain this in simple terms. If your child is reluctant to take this drug now, read this and then tell him the tale of the courageous protector of all sick children Amosin. Believe me, you will no longer have to persuade the baby to take the next dose. He will gladly drink the medicine himself.

So, "Amosin 250" is a modern broad-spectrum antibiotic. It is closely related to semi-synthetic penicillins. Works like a riot police - quickly and decisively. The active substance is amoxicillin. Its goal is harmful microbes of various origins. The drug enters the body, after 15-20 minutes it penetrates the cell of a harmful bacterium and reduces the speed of all chemical processes that occur in it. Destroys the structure, membrane, enzymes.

The "evil" cell also wants to live, it begins to actively resist and, as a result, spends the last of its strength. "Amosin" is adamant. Its action lasts up to 8 hours. Some "enemy" cells try to attack it with acid. But the valiant antibiotic is resistant to it. So he wins 100% of the time. It is excreted from the body rather quickly, with the formation of inactive metabolites. This means that the decay products are not toxic.

In addition to otitis media, bronchitis and a host of other colds, the remedy successfully copes with such “serious” rivals as sinusitis, salmonellosis and meningitis. Deals with skin infections. Most often, the drug is recommended specifically for angina, since this disease is caused by bacteria of various types.

Instructions for use

"Amosin 250" is different: powder, granules. There is a solution for intramuscular and intravenous use. But for children, most often the remedy is prescribed in tablets. Babies aged 2-3 years are usually recommended to take an antibiotic in the form of a suspension. It is easy to drink, it is quite pleasant in taste and smell due to the vanillin added by the manufacturer to the main composition. In the form of syrup "Amosin" is not available.

The dosage is determined by the doctor. It depends on the age of the child. "Amosin 250" can be given even to newborns from the first days of life.

Parents will have to prepare the suspension for children on their own. To do this, the powder is simply added to chilled boiled water. "Amosin 125" (a drug with an active ingredient content of 125 mg) should be diluted in 2.5 ml. water. For a 250 mg product, 5 ml of water will be required, respectively. For 500 mg - 10 ml. liquids.

The dosage and schedule of administration is usually the same.

• Babies from birth to 2 years old: three times a day. The total daily dosage is 20 mg suspension per kilogram of patient weight.
• Preschoolers up to 5 years old inclusive can take 125 mg. suspension three times a day.
• Children from 5 to 10 years old: three times a day, 250 mg.
• Schoolchildren over 10 years old 500 mg of "Amosin" also three times a day.

Tablets and capsules of the drug are not given to children under 2 years old!

Sometimes "Amosin" is prescribed to children for the prevention of endocarditis or surgical infection. In this case, doctors recommend starting with half the adult dose.

Contraindications

Be sure to tell the doctor who prescribes Amosin to your child if the baby has at least one of these diseases:

• allergic diathesis;
• allergy to flowering (hay fever);
• bronchial asthma;
• liver failure;
• kidney disease;
• recurrent bleeding.

All these diagnoses are a strict contraindication to taking this antibiotic.

The drug should not be taken also by children who have ever had colitis or are allergic to antibiotics.

Side effects

Do not forget that, like any powerful antibiotic, the remedy can cause side effects. The instructions for use describe the following symptoms:

• disorders of the gastrointestinal tract;
• nausea;
• allergic rhinitis;
• the appearance of a rash and itching;
• shortness of breath, sleep disturbance, depression of the central nervous system, tearfulness of the child.

If your son or daughter has any of the above, be sure to tell the doctor about it - he will adjust the dosage and give the necessary recommendations.

Overdose

If it so happens that the child has taken a dose of the drug in excess of that prescribed by the doctor, carefully observe him. An ambulance should be called if symptoms such as nausea, severe vomiting, abdominal pain, dizziness appear. Only emergency specialists can help in this situation, because a powerful antibiotic acts quickly, and there is simply no antidote for it. Doctors will promptly wash the stomach with saline and remove the intoxication of the body. Self-medication in this case is extremely dangerous.

Price

"Amosin" is more than affordable. Its average cost in Russian pharmacies is about 70 rubles (sachets for preparing a suspension), 27-40 rubles (tablets). A little more than 60 rubles is the drug in capsules. Prices in different regions of the country and pharmaceutical chains may differ, however, slightly.

Shelf life and storage conditions

The drug should be stored in a place protected from moisture and direct sunlight, at a temperature not higher than + 25C and not lower than + 15C, no more than 2 years from the date of manufacture. The drug is released strictly according to the prescription.

Analogues

Amosin 250 is an antibiotic of domestic production. The manufacturer is the pharmaceutical company Sintez AKO JSC (Kurgan region).

The situation with analogues is quite interesting. Usually the original drug is more expensive than analogues. But here it's the other way around. Drugs with a similar effect are as follows:

Flemoxin Solutab. Produced in Holland. A pack of tablets (20 pieces) costs more than 300 rubles.

Augmentin. An antibiotic of bacterial action comes from England. A pack of tablets (20 pieces) costs more than 250 rubles. By the way, pediatricians often like to prescribe Augmentin to their patients. In order not to overpay, it makes sense for parents to check with the doctor if it can be replaced with our original Amosin, which costs almost 5 times cheaper.

Amoxiclav. Another drug with a similar effect. Produced in Slovenia. It costs more than other analogues. For a package of 14 tablets, you will have to pay 250 rubles.