Analgin Belmed: instructions for use. Analgin (500 mg, Khimfarm AO) Analgin tablets 500 mg
active substance- metamizole sodium 500.0 mg,
Excipients: sucrose, talc, potato starch, calcium stearate.
Tablets are white or white with a slightly yellowish tinge of color, flat-cylindrical shape with a chamfer and a risk.
Farmacotherapeutic group
Other analgesics-antipyretics. Pyrazolones. Metamizole sodium
Pharmacokinetics
When taken orally, it is rapidly and completely absorbed. There is no unchanged metamizole in the blood.
Excreted by the kidneys as metabolites. Metabolites are excreted in breast milk. The action develops in 20-40 minutes and reaches a maximum after 2 hours. The maximum concentration is reached 1-1.5 hours after parenteral administration. The half-life is about 7 hours. Metabolites are completely excreted in the urine, 71% of the administered dose is found in the range from 0 to 24 hours, 18% - from 24 to 48 hours.
Pharmacodynamics
Analgin has an analgesic, antipyretic and weak anti-inflammatory effect. It is a derivative of pyrazolone. The mechanism of action is associated with inhibition of the activity of cyclooxygenase types I and II. As a result, the reactions of the arachidonic cascade of eicosanoid synthesis are blocked and the formation of prostaglandins PgE2, PgF2α, their endoperoxides, and bradykinin is disrupted. In the nuclei of the antinociceptive system, analgin enhances the release of kynurenic acid, which inhibits the conduction of pain impulses (due to the effect on NMDA receptors).
It prevents the conduction of pain impulses from extra- and proprioceptive receptors along the Gaulle and Burdach bundles, increases the excitability threshold of the pain centers of the thalamus. At the same time, it enhances heat transfer, reduces the activity of the hypothalamic thermosetting center.
Pain syndrome, mild or moderate (headache, toothache, neuralgia, myalgia, dysmenorrhea, postoperative pain)
Fever in infectious and inflammatory diseases
1 tablet 2-3 times a day after meals. The maximum single dose is 1 g, the daily dose is 3 g. Adults and children over 15 years of age are prescribed 250-500 mg (½-1 tablet) 2-3 times a day.
The duration of admission is not more than 5 days when prescribed as an anesthetic and not more than 3 days as an antipyretic.
Nausea, vomiting, anorexia, epigastric pain, flatulence,
Headache, dizziness, agitation, irritability
Allergic reactions (skin rash, itching, angioedema),
erythema multiforme exudative (Stevens-Johnson syndrome),
toxic epidermal necrolysis (Lyell's syndrome),
bronchospastic syndrome, anaphylactic shock
Paresthesia, tinnitus, blurred vision, tremor, depression
Agranulocytosis, leukopenia, anemia, thrombocytopenia (with prolonged
Arterial hypotension, cardiac arrhythmias
Oliguria, anuria, proteinuria, impaired renal function,
Hypersensitivity to analgin, other derivatives
pyrazolone (phenylbutazone, tribuzone) or other auxiliary
Liver and/or kidney failure
Inhibition of hematopoiesis (agranulocytosis, cytotoxic or
infectious neutropenia), anemia, leukopenia
Peptic ulcer of the stomach and duodenum, gastrointestinal
Asthma attacks, urticaria, history of acute rhinitis,
associated with the use of acetylsalicylic acid or other
non-steroidal anti-inflammatory drugs
Children's age up to 15 years
Pregnancy and lactation
With simultaneous use with other analgesics, antipyretics and non-steroidal anti-inflammatory drugs, mutual enhancement of toxic effects is possible.
The action of Analgin is enhanced when used together with barbiturates, codeine, H2-blockers of histamine receptors, anaprilin (due to slowing down the inactivation of the drug).
Increases the risk of developing leukopenia when used together with thiamazole and cytostatic agents.
Analgin displaces oral hypoglycemic agents from their association with blood plasma proteins and, thereby, increases their effect.
It enhances the activity of indirect anticoagulants, glucocorticosteroids and indomethacin due to their displacement from the connection with plasma proteins.
Analgin enhances the sedative effect of ethyl alcohol.
Analgin lowers the concentration of cyclosporine A in the blood plasma.
With simultaneous use with phenothiazine derivatives, severe hyperthermia may develop.
Tricyclic antidepressants, combined oral contraceptives and allopurinol slow down the metabolism of Analgin and increase its toxicity, sedatives and anxiolytics enhance the analgesic effect of Analgin.
With simultaneous use with myotropic antispasmodics (drotaverine, papaverine, pitofenone) and m-anticholinergics (fenpiverinium bromide, platifillin, atropine), there is a mutual enhancement of the analgesic, antispasmodic and antipyretic activity of this combination.
Caffeine enhances the effect of the drug.
With simultaneous use with inducers of microsomal liver enzymes, the effectiveness of Analgin may decrease.
Long-term use of Analgin
If it is necessary to regularly use Analgin for more than 5 days, the picture of peripheral blood should be monitored weekly.
Use in individuals with pathology of the cardiovascular system
Careful monitoring of hemodynamics is necessary, especially in patients with systolic blood pressure levels below 100 mm Hg. Art. or with circulatory instability (eg, myocardial infarction, multiple trauma, incipient shock), with a history of kidney disease (pyelonephritis, glomerulonephritis), as well as in people with alcohol dependence.
In the event of an unexpected deterioration in the general condition of the patient during treatment with Analgin, manifested by fever, inflammation of the mucous membranes of the oral cavity and pharynx (necrotizing stomatitis, purulent-necrotic tonsillitis), nose (sinusitis), increased ESR, the drug should be stopped immediately, because . these symptoms may be associated with the development of agranulocytosis.
Excretion with urine of biotransformation products Analgin can cause red staining of urine, which has no clinical significance and disappears after discontinuation of the drug.
Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
Receiving Analgin does not affect the ability to drive vehicles or potentially dangerous mechanisms, but care should be taken with prolonged use.
Symptoms: nausea, vomiting, stomach pain, hypothermia, lowering blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, impaired consciousness, delirium, acute liver and / or kidney failure, convulsions, paralysis of the respiratory muscles, agranulocytosis.
Treatment: withdrawal of the drug, gastric lavage, taking saline laxatives and activated charcoal to prevent absorption of the drug in the stomach and intestines, symptomatic therapy aimed at maintaining vital functions. Carrying out forced diuresis and the introduction of sodium bicarbonate in order to alkalinize urine accelerate the excretion of the drug. There is no specific antidote for metamizole sodium. The main metabolite of metamizole (4-methylaminoantipyrine) can be removed by hemodialysis, hemofiltration, hemoperfusion and plasmapheresis. With the development of a convulsive syndrome - intravenous administration of diazepam and high-speed barbiturates.
Release form and packaging
10 tablets in a blister pack made of PVC film and printed lacquered aluminum foil.
10 tablets in a blister pack made of paper with a polyethylene coating.
Boundary packages with an equal number of instructions for medical use in the state and Russian languages are placed in a group cardboard box.
Store in a dry, dark place at a temperature not exceeding 25º C.
Keep out of the reach of children!
Do not use after the expiration date.
JSC "Irbit Chemical-Pharmaceutical Plant"
Address of the organization accepting claims from consumers on the quality of products on the territory of the Republic of Kazakhstan
JSC "Irbit Chemical-Pharmaceutical Plant"
623856, Russia, Sverdlovsk region, Irbit, st. Kirov, 172
source
Analgin is a non-narcotic pain reliever. It has analgesic, antipyretic and antispasmodic effects.
Analgin is available in the following dosage forms:
- Flat-cylindrical tablets 500 mg of white or yellowish color with a bitter taste, 10 pieces in a blister or non-blister pack;
- Suppositories for rectal use 100 mg, 5 pieces in a blister pack;
- Solution for injection 25% and 50%, in ampoules of 1 ml or 2 ml;
- Solution for intramuscular and intravenous administration 250 mg / ml and 500 mg / ml, in ampoules of 1 ml or 2 ml.
The active substance is metamizole sodium (analgin).
- Sugar;
- Potato starch;
- Talc;
- calcium stearate.
The use of Analgin is indicated for pain syndromes of various etiologies:
- Infectious and inflammatory processes;
- Insect bites - mosquitoes, bees, gadflies and others;
- Post-transfusion complications;
- neuralgia;
- Myalgia;
- Arthralgia;
- biliary colic;
- Intestinal colic;
- renal colic;
- Injuries;
- burns;
- decompression illnesses;
- Shingles;
- orchitis;
- Radiculitis;
- myositis;
- Postoperative pain syndromes;
- headaches;
- toothaches;
- Algodysmenorrhea.
Analgin is contraindicated in:
- hypersensitivity;
- Prolonged abuse of ethanol;
- Agranulocytosis;
- Infectious or cytostatic neutropenia;
- Liver or kidney failure;
- Hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase;
- Bronchial asthma induced by taking acetylsalicylic acid, salicylates or other non-steroidal anti-inflammatory drugs;
- anemia;
- Leukopenia;
- Pregnancy, especially in the first trimester and in the last 6 weeks;
- lactation.
In addition, intravenous administration of Analgin to patients with systolic blood pressure below 100 mm Hg or unstable blood circulation against the background of myocardial infarction, shock, multiple trauma is prohibited.
The instructions for Analgin indicate that it should be prescribed with caution to infants under 3 months old, as well as to patients with kidney disease - pyelonephritis and glomerulonephritis, including a history.
Analgin tablets are taken orally, 2-3 times a day, 250-500 mg. The maximum dose should not exceed 1 g per 1 dose and 3 g per 1 day.
A single dose for children from 2 years old is 50-100 mg, from 4 years old - 100-200 mg, from 6 years old - 200 mg, from 8 to 14 years old - 250-300 mg 2-3 times a day.
Intramuscularly or intravenously, adults are prescribed 250-500 mg 3 times a day. The maximum daily dose is 2 g.
Children's dosage is calculated by body weight and is 5-10 mg / kg 2-3 times a day. For children under the age of 1 year, Analgin is administered only intramuscularly.
The solution for injection should be at body temperature when administered. More than 1 g should be administered intravenously, while providing conditions for anti-shock therapy.
Intravenous administration of Analgin, according to the instructions, must be done slowly, not faster than 1 ml / min, in the supine position and under the control of blood pressure, respiratory rate and heart rate. These precautions are due to the fact that a high injection rate is the main cause of a sharp decrease in blood pressure.
The adult dosage for rectal use is 300, 650 and 1000 mg, and for children it depends on the nature of the disease and age. In particular, children from 6 months to 1 year are prescribed 100 mg, from 1 year - 200 mg, from 3 years - 200-400 mg, from 8 to 14 years - 200-600 mg. After using Analgin in suppositories, you must be in bed.
Analgin can cause the following side effects:
- Impaired kidney function;
- Oliguria;
- Anuriy;
- Interstitial nephritis;
- Proteinuria;
- Red staining of urine;
- Urticaria (including on the mucous membranes of the nasopharynx and conjunctiva);
- Angioedema;
- Toxic epidermal necrolysis;
- Malignant exudative erythema;
- bronchospastic syndrome;
- Anaphylactic shock;
- Agranulocytosis;
- Leukopenia;
- thrombocytopenia;
- Decreased blood pressure;
- Infiltrates at the site of intramuscular injection.
An overdose of Analgin may be accompanied by a number of symptoms:
- nausea;
- vomiting;
- gastralgia;
- Oliguria;
- Hypothermia;
- Decreased blood pressure;
- tachycardia;
- shortness of breath;
- Noise in the ears;
- drowsiness;
- delirium;
- Violation of consciousness;
- Acute agranulocytosis;
- hemorrhagic syndrome;
- Acute renal and / or liver failure;
- convulsions;
- Paralysis of the respiratory muscles.
Treatment consists of gastric lavage, administration of activated charcoal and saline laxatives, as well as forced diuresis and hemodialysis. With the development of a convulsive syndrome, intravenous administration of diazepam and high-speed barbiturates is necessary.
Intolerance to Analgin is rare, but the risk of anaphylactic shock after intravenous administration of the drug is higher than after taking tablets.
With atopic bronchial asthma and hay fever, the likelihood of allergic reactions increases.
Before establishing the causes of acute pain in the abdomen, the drug should not be used.
Due to the excretion of metabolites, urine may turn red (does not matter).
For intramuscular injection, a long needle should be used.
Metamizole sodium is the active ingredient in Baralgin tablets.
Analogues of Analgin are:
- Antipyrine;
- Baralgetas;
- Quintalgin;
- Maxigan;
- Pentalgin;
- Revalgin;
- Spazmalgon;
- Tempalgin;
- Sedalgin.
Store in a dry dark place. Keep away from children.
Found a mistake in the text? Select it and press Ctrl + Enter.
source
Analgin is a non-steroidal anti-inflammatory drug, a non-narcotic pain reliever. Analgin reduces and removes completely pain without affecting the psyche.
Analgin has a pronounced anti-inflammatory, analgesic, antipyretic properties.
According to the instructions for use, Analgin is available in tablets, rectal suppositories and ampoules (solution for intramuscular and intravenous use).
For children, analgin is produced in the form of rectal suppositories and tablets.
Analgin is used as a non-specific remedy for febrile conditions, rheumatism, acute respiratory infections (flu, parainfluenza, etc.), chorea.
Also, according to the instructions for use, Analgin is used as an anesthetic for pain of various origins (neuritis, neuralgia, myositis, radiculitis).
Analgin is usually taken at 250-500 mg two to three times a day. The maximum allowable single dose is not more than 1g, and 3g per day.
Intravenously or intramuscularly, Analgin is used (for severe pain, for example) three times a day - 250-500 mg. In this case, a single dose should not exceed 1 g, and a daily dose should not exceed 2 g.
Rectally, Analgin is administered to adults in dosages of 1000, 650, 300 mg.
Analgin for children under the age of one year is given only in the form of intramuscular injections, and the temperature of the solution should not differ from body temperature. If the dose of Analgin is more than 1 g, it is administered intravenously, and conditions must be created for anti-shock therapy if necessary.
Single doses of Analgin for children (tablets inside): at 2-3 years - 50-100 mg, at 4-5 years - 100-200 mg, at 6-7 - 200 mg, at 8-14 - 250-300 mg. The multiplicity of reception - two to three times in 24 hours.
Analgin's solution for children is also prescribed two to three times a day, counting 5-10 mg per kilogram.
Analgin rectal suppositories are prescribed for children, taking into account the age and nature of the course of the disease. According to the instructions for use of Analgin, 100 mg suppositories are recommended for children from six months to a year; 200mg for children aged 1-3; 200-400mg for 3-7 years old and 200-600mg for children 8-14 years old. After the administration of the drug rectally, the child needs to lie down.
- blood diseases;
- oppression of hematopoiesis;
- pregnancy (especially the first 3 months, the last 6 weeks), lactation;
- individual intolerance;
- with rheumatic attack;
- dysmenorrhea;
- renal, hepatic insufficiency;
- aspirin asthma;
- leukopenia;
- anemia;
- hereditary hemolytic anemia (associated with insufficiency of glucose-6-phosphate dehydrogenase).
Give with caution Analgin to children under 3 months, as well as kidney diseases (glomerulonephritis, pyelonephritis), prolonged abuse of ethanol. Also under control is intravenous medication with systolic blood pressure less than 100 mm, with unstable blood circulation (occurs, for example, due to a heart attack, multiple trauma, at the beginning of a shock reaction).
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Information about the drug is generalized, provided for informational purposes and does not replace the official instructions. Self-medication is dangerous to health!
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Self-medication is a risky business. However, what to do if you suddenly have a headache or a toothache, and the time for visiting the clinic is over? In such life situations, most will reach for a home first aid kit for a proven remedy. However, before drinking the medicine, you need to find out everything about its dosage, side effects. For example, it will provide additional information about the principles of action of the drug Metamizol or Analgin - instructions for use.
It is known that Analgin is a simple non-steroidal drug from the group of pyrazoles, which has antipyretic and analgesic properties. The working name of Analgin is metamizole sodium. Knowing the middle name of the tablets is necessary in order not to overpay when buying analogue drugs. Often, expensive drugs at the bottom of the box have the inscription metamizole sodium or metamizole natricum - this means that you bought the most common Analgin, but at an inflated cost.
Due to the peculiarities of the chemical composition, Analgin can anesthetize, relieve fever, but has a weak anti-inflammatory effect. Due to this, the medicine is often used to eliminate the activity of pain syndromes, lower body temperature, but never to treat the inflammatory process. Summarizing all of the above, we can safely say that Analgin helps in the presence of:
- moderate intensity or mild pain syndrome (migraines, headaches or toothaches, cystitis, myositis, sciatica, intercostal neuralgia, biliary or intestinal colic);
- in violation of the functional course of menstruation and dysmenorrhea;
- moderate burns, postoperative incisions, injuries;
- infectious and inflammatory processes in the respiratory tract (pneumonia, SARS, influenza, otitis and other diseases);
- in case of complications after blood transfusion.
The main active ingredient of the drug is sodium phenyl-dimethyl-methylaminopyrazolone-methanesulfonate or, simply speaking, sodium metamizole. The composition of Analgin of all forms and varieties includes only this component without any auxiliary substances. In appearance, it is a white powder without a characteristic odor, which lends itself to good interaction with water, but is poorly soluble in alcohol. However, the composition of Analgin in tablets of combined action, in addition to metamizole, includes another component - quinine.
A popular form of release of Analgin is tablets, dragees or capsules. However, no less common is a medicinal preparation in ampoules or as a component of an injection solution. It is worth knowing that suppositories for rectal use called Spazdolzin are also a derivative of Analgin. All medicinal varieties of the drug differ from each other only in the content of metamizole. Eg:
- The standard dosage of the active components of the tablets is 500 mg per 1 pc.
- Analgin in ampoules contains 250/500 mg of the substance per 1 or 2 ml.
- There is also a special preparation for children. The concentration of metamizole is 50/100/150 mg.
- Candles Spazdolzin for adults contain 650 mg of the substance, and the children's version - 200 mg.
When using Analgin, it should be remembered that the drug only relieves symptoms - relieves pain, relieves fever, but does not cure the disease itself, which caused such phenomena. Each dosage form is used in a specific case. For example, taking Analgin tablets is better for severe headache or toothache. Adults can drink one capsule to relieve biliary or intestinal colic. It is advisable to give injections only in the presence of a high temperature.
The dosage of Analgin in capsules depends on the age of the patient, the intensity of pain and the body's response to medication. To start treatment, it is better to choose the minimum dosages that can relieve vasospasm and relieve fever. Round tablets are easy to swallow, but it is still recommended to drink plenty of liquid - warm milk, still water.
Instructions for use of Analgin tablets indicate that for children over ten years of age and adolescents, the simultaneous dose of the drug should be selected at the rate of 8-16 mg of metamizole per 1 kg of weight.
For adults, the daily allowance can be increased to 1000 mg at a time. The table below will help you calculate the required number of tablets according to the age and weight of the patient:
Optimal weight and age
Maximum daily dose
Analgin for children under 14 years old (35-50 kg)
As indicated in the instructions for use, the calculated dosages should be reduced in the treatment of headaches or fever in elderly patients, since the excretion of the metabolite from the body with urine will be slower. In addition, people with impaired liver or kidney function should consult their doctor before taking the pill. In the presence of any of these changes, long-term treatment with Analgin is unacceptable.
Subcutaneous administration of Analgin injections is unacceptable, as it can lead to severe allergic reactions and an inflammatory process. Injections of any dosage are done only intravenously or intramuscularly. It is advisable to do injections only when other drugs do not help or the person is in critical condition and cannot take a pill.
According to the instructions of Analgin in ampoules, the dosage of the drug is calculated according to the age of the patient, for example:
- Adolescents from 14 years of age and adults are given up to 2500 mg of metamizole sodium per injection, and the maximum daily volume is 5000 mg. Analgin injections are made up to 3 times a day, observing a 4-hour interval between them.
- Analgin is administered to children at a temperature in the minimum dosage, calculated from the ratio of 4-10 mg per 1 kg of weight. The result obtained must be divided by 2, and the drug should be administered 2-3 times a day.
The injected solution for injection should be within body temperature, therefore, after taking the liquid into the syringe, it must be warmed up in the palms for some time. An injection is administered, as a rule, intramuscularly, but in a critical condition it is permissible to inject intravenously. It is strictly forbidden to store opened ampoules on the table, in the refrigerator or in other places. If the drug has stood open for more than 15 minutes, then it is considered unsuitable for use.
Metamizole sodium in tablets or injections can be given to a child from the age of 10, otherwise the body's reaction may be unpredictable - as indicated in the instructions for use. For children of the younger age group, it is customary to treat with the help of rectal suppositories, since they have the proper therapeutic effect without a detrimental effect on the stomach and body of the baby as a whole.
Instructions for the use of Analgin for children indicate the need to comply with the correct dosages. If these are candles, then it is customary for children up to a year to enter 1 capsule per day. Babies over 2 years old can put two candles per day. As for tablets and solutions, the dosages remain the same and are calculated strictly according to the weight of the child. Parents should understand that regular intake of Analgin does not guarantee recovery and can cause a lot of negative reactions.
Excessive medication can lead to the following symptoms:
- nausea, vomiting, stomach pain;
- rapid heart rate, lowering blood pressure and body temperature below normal;
- the appearance of drowsiness, weakness, tinnitus, impaired consciousness;
- hemorrhagic syndrome, blood disorders;
- pathologies of the liver or kidneys;
- paralysis of the respiratory system.
In case of an overdose, it is important to provide first aid to the victim in time. To do this, it is necessary to do a gastric lavage, induce artificial vomiting, if there is none. After that, it is desirable to give the patient cleansing sorbents or laxatives: Magnesia, Polysorb, Filtrum, Enterosgel, activated charcoal. If a similar phenomenon happened at the hospital, then hemodialysis is performed.
As a rule, taking tablets with metamizole sodium passes without any consequences for a person. However, due to individual reactions of the body, negative reactions from various systems and organs may occur. Side effects of Analgin can lead to the following disorders:
- From the side of the cardiac system: a decrease in blood pressure.
- In the form of allergic reactions: the appearance of a rash, bronchial asthma, shortness of breath, Quincke's edema.
- The action of Analgin on the nervous system: convulsions, migraine.
- Hematopoiesis: a decrease in the number of leukocytes, platelets, basophils and eosinophils.
- From the urinary system: difficulty in excreting urine, the appearance of protein, staining of feces in red, the development of nephritis.
- Reactions from the digestive system: stomach pain, dry mouth, nausea.
The instructions for use indicate that due to the absorption of the active substance into breast milk, it is unacceptable to take Analgin during lactation. Since there is no reliable data on the safety of the drug for the fetus, the drug cannot be recommended during pregnancy, especially in the last and first trimester. Otherwise, Analgin's contraindications are as follows:
- sensitivity to the active ingredient;
- bronchial diseases;
- violation of the functions of hematopoiesis;
- acute liver failure;
- kidney pathology;
- children's age up to 3 months.
Analgin is not only part of many drugs, but is often used with some of them in combination. A typical example of interaction with other drugs is:
- Diphenhydramine + Analgin or Suprastin + Analgin is used to lower the temperature.
- Analgin-Papaverine-Diphenhydramine - the combination is used if the patient has cold hyperthermia.
- Aspirin-Analgin is used for viral infections.
- Paracetamol + Analgin is used to lower the temperature in children.
- Novocaine + Analgin - a combination for pain relief.
In many countries, Analgin is considered dangerous and banned for sale due to the likelihood of agranulocytosis - the ability to affect blood cells. However, in Russia and neighboring countries, this medicine can be bought everywhere at an affordable price. Nevertheless, doctors advise not to rush to make a choice, but if possible, purchase analogues of Analgin. Eg:
- ibuprofen;
- Sedal-M;
- Spazmalgon;
- Pentabufen;
- Maxigan;
- Tempalgin;
- Spazgan;
- Quintalgin;
- Baralgin.
You can buy medicine inexpensively without a doctor's prescription at any pharmacy in your city. In addition, in modern realities, many people prefer to receive medicines without leaving their homes, because they can be ordered through the catalog of official manufacturers or bought in an online store. When receiving tablets, ampoules or suppositories with delivery, do not forget to check the quality of the drugs, ask for a certificate and check the expiration date. How much does Analgin cost in tablets in Moscow, you can find out from the following table:
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The description is up to date 11.11.2015
- Latin name: analgin
- ATX code: N02BB02
- Active substance: INN: Metamizole sodium (Metamizole sodium)
- Manufacturer: Krasnaya Zvezda JSC, Lekhim-Kharkov CJSC, Lubnypharm PJSC, Darnitsa PJSC, Health LLC, Ukraine Mapichem AG, Switzerland
The composition of Analgin in tablets: 500 mg metamizole sodium , excipients - talc, potato starch, powdered sugar, calcium stearate.
Compound injection solution: metamizole sodium at a concentration of 500 mg / ml, the auxiliary substance is water for injection.
The composition of Analgin in the form suppositories: 100 or 250 mg metamizole sodium , excipient - solid fat.
- Tablets 500 mg. Packing No. 10*1 and No. 10*2; for hospitals - packaging No. 10 * 30 and No. 10 * 390.
- Injection solution 500 mg / ml in 1 or 2 ml ampoules, package No. 10 * 1.
- Rectal suppositories (for children) 100 mg and 250 mg, package No. 10.
Analgesic (painkiller).
Pharmacological group: metamizon - This analgesic-antipyretic from the group of drugs "NSAIDs - Pyrazolones". Code OKPD Analgin - 24.41.31.122.
Mechanism of action metamizole similar to the mechanism of action of other NSAIDs. The substance inhibits (non-selectively) the activity of the COX enzyme, which is involved in the synthesis of prostanoids, reduces the formation of certain Pg, endoperoxides, free radicals and bradykinins, and inhibits lipid peroxidation.
The effect of action cannot be called absolute, as is the case with other NSAIDs, since it can be blocked by stimulation of inflammatory receptors.
It prevents the conduction of proprioceptive and exteroceptive impulses along the Burdach and Gaulle bundles, increases the excitability threshold of pain sensitivity centers in the thalamus and the intensity of heat transfer.
Anti-inflammatory activity metamizole expressed slightly, due to which the drug has practically no effect on the exchange of water and electrolytes (retention of water and Na + ions) and the mucous membrane of the digestive canal.
Apart from pain relief , the drug helps to reduce body temperature when hyperthermia and causes some antispasmodic effect (in particular, relieves spasm of smooth muscles of the bile ducts and urinary tract).
Action metamizole develops 20-40 minutes after taking the pill, the maximum severity of the effect is observed after two hours.
The results of a comparative analysis of the effectiveness of the application aspirin and analgin on temperature show that antipyretic activity metamizole less than aspirin , but it is much higher when compared with analgin Paracetamol And Ibuprofen .
Analgesic effect when applying metamizole also more pronounced than when using Ibuprofen/Paracetamol .
The substance is rapidly and very well absorbed from the alimentary canal. In the walls of the intestine, it undergoes hydrolysis with the formation of a pharmacologically active metabolite.
Unmodified metamizole sodium in the blood is not detected (insignificant concentrations of the substance are determined in the plasma only with the introduction of Analgin in / in).
Communication of a metabolite with plasma proteins - 50-60%.
Metabolized metamizole in the liver, the excretion of the substance is carried out by the kidneys. T1 / 2 - 1-4 hours.
The substance passes into breast milk.
Main action metamizole - painkiller . This allows the use of the drug for the relief of pain syndrome of various etiologies: Analgin helps with headaches, menstrual and toothache, pain associated with sciatica , neuralgia , myalgia , colic (intestinal, hepatic or renal), heart attack (lung or myocardium), thrombosis of the main vessels , dissecting aortic aneurysm , inflammatory processes ( lumbago , pneumonia , myocarditis , pleurisy etc.), burns, injuries, decompression sickness, tumors, pneumothorax , perforation of the esophagus , orchitis , shingles , priapism , pancreatitis , post-transfusion complications , peritonitis .
Other indications for the use of Analgin in the form tablets And injection solution:
- chorea ;
- rheumatism ;
- arthralgia ;
- febrile syndrome with insect bites and acute urological, purulent or infectious diseases.
The use of Analgin is resorted to when other therapeutic measures do not alleviate intense pain (acute or chronic).
Analgin in ampoules is prescribed in exceptional cases: when enteral use of the drug is impossible, for the relief of very severe postoperative pain, in situations where you need to quickly bring down the heat. Sometimes (rarely enough) injections are used in therapy arthritis And osteochondrosis .
For moderate pain (for example, with a headache), it is usually enough to take a pill.
Suppositories are intended for the treatment of children older than one year of age.
In children, it is advisable to use Analgin for toothache, headache, pain with burns, myositis , radiculitis , neuralgia . Candles with Analgin are also effective for pain in the postoperative period.
The annotation lists the following contraindications to the use of Analgin:
- hypersensitivity to metamizole , derivative pyrazolone , pyrazolidins (the drug is not prescribed, including to persons who have been diagnosed with the use of these drugs agranulocytosis ), auxiliary components of tablets;
- aspirin asthma in history;
- intolerance syndrome to simple analgesics or NSAIDs;
- oppression (depression) of the bone marrow or pathological conditions of the hematopoietic system;
- congenital forms hemolytic anemia due to deficiency of the cytosolic enzyme G6PD;
- acute intermittent porphyria ;
- unstable hemodynamics and/or arterial hypotension ;
- suspicion of acute surgical pathology.
In pediatric practice, tablets are used from the age of ten, suppositories - in children older than a year.
Intramuscularly, the drug should not be administered to children under three months, as well as children weighing up to five kilograms. A contraindication for intravenous administration of Analgin is children's age from three to eleven months.
Side effects of application metamizole sodium appear in the form:
- agranulocytosis ;
- granulocytopenia ;
- thrombocytopenia ;
- hypotension ;
- hemorrhages ;
- hypersensitivity reactions;
- interstitial nephritis .
When using Analgin tablets, the dosage is selected depending on the intensity of pain and the individual response of the body to treatment. It is considered optimal to use the minimum dose that controls fever and pain.
Tablets are swallowed whole and washed down with a large (about 200 ml) volume of liquid.
For an adult weighing more than 53 kg, a single dose of Analgin is 0.5-2 tablets. If one dose was not enough, the maximum single dose (two tablets) can be taken three more times during the day. The safe upper limit of the daily dose is 4 grams (eight tablets).
With toothache, Analgin is taken from half a tablet. If this does not help relieve the pain, you can drink the remaining half.
The dose is selected depending on the severity of the pain syndrome, fever, age and body weight of the patient, individual response to treatment. It should be as low as possible, while still allowing pain and fever to be controlled.
A single dose for patients weighing more than 53 kg varies from 500 mg to 1 g. This means that 1-2 ml of solution should be taken for one injection. If this is necessary, a single dose can be increased to 2.5 g (5 ml of solution). Permissible upper limit of the daily dose - 5 g metamizole sodium (corresponds to 10 ml of solution).
The method of administration of the drug depends on the condition of the patient and the desired therapeutic effect. In most cases, oral administration is sufficient to improve the patient's condition.
Analgin i / v and / m is administered when you need to get the result quickly. With parenteral administration, the likelihood of developing anaphylactoid / anaphylactic reactions is higher than when taking tablets or using suppositories.
For children under one year old, the solution can only be administered intramuscularly. In this case, the temperature of the injected fluid should be as close as possible to body temperature.
Bieffe complex sodium lactate solution (Ringer's lactate), 5% glucose solution, or 0.9% aqueous sodium chloride solution can be used as a solvent. Due to the limited stability of these solutions, they should be used immediately.
Due to potential incompatibility, Analgin's solution is not recommended for use in the same intravenous infusion system or in the same syringe with other drugs.
The difference of the drug Analgin-quinine from the usual Analgin is that in addition to its composition metamizole sodium (200 mg/tab.) also included quinine (50 mg/tab.).
Quinine suppresses the thermoregulation center located in the hypothalamus, and in the case of high doses, the visual and auditory zones of the cerebral hemispheres.
The drug is prescribed for pain syndrome of various origins, infectious and inflammatory diseases , and also (in combination with antispasmodics ) at biliary and renal colic .
Often Analgin-quinine in gynecology, it is prescribed for conditions after childbirth and abortion.
In accordance with the instructions, the drug is used from the age of twelve. Patients under 14 years of age should take 3 tablets per day. one at a time, from the age of 14, a single dose can be increased to two tablets.
Depending on the clinical picture, one to six tablets can be taken during the day (1-2 pcs. 1-3 rubles / day).
As antipyretic Analgin-quinine without consulting a doctor, you can take no more than three days in a row, as analgesics - no more than five days in a row.
After taking the pill metamizole begins to act in twenty to forty minutes. It takes an average of two hours to achieve the maximum effect.
The effect after the injection develops somewhat faster.
In the elderly, as well as in patients with reduced kidney function and impaired Clcr, Analgin is used at a lower dosage, since metabolites metamizole sodium they may be excreted more slowly than in younger patients and patients with normally functioning kidneys.
High doses should be avoided in patients with reduced hepatic and/or renal function. metamizole sodium . Without dose reduction, only short-term use of the drug is possible. Long-term use is not possible.
Patients receiving Analgin for a long time should regularly take a blood test for counting leukocytes .
Does Analgin lower or increase blood pressure? This question is often asked by people prone to fluctuations in blood pressure. The manufacturer's instructions indicate that the use of metamizole may be associated with the risk of dose-dependent hypotension, as well as hypersensitivity reactions.
Therefore, the advisability of using the drug at a dose exceeding 1 g requires an assessment of the benefit/risk ratio.
The solution is administered under close medical supervision with the patient lying down.
To reduce the risk of a sharp decrease in blood pressure and to ensure the timely termination of the administration of the solution with the development of anaphylactoid / anaphylactic reactions, Analgin IV must be administered very slowly (the rate of administration should not exceed 1 ml / min).
To reduce the adverse effect metamizole on the gastric mucosa, pharmacists recommend replacing the usual Analgin with the drug Analgin Ultra . These tablets are coated with a protective shell, due to which metamizole less irritating to the digestive tract.
The combination of Analgin with Dimedrol it is used in critical situations when it is necessary to bring down a very high temperature (including in infants).
One of the most effective means at a high temperature, which other means cannot cope with, is the injection of the “triad” Analgin- Diphenhydramine -Papaverine . Combinations help just as well. Tavegil , Analgin and No-shpa or Analgin, No-shpa And Suprastin from temperature. After intramuscular administration of any of these mixtures, the temperature drops after fifteen minutes.
Papaverine renders antispasmodic And myotropic action , contributing to the opening of spasmodic vessels and lowering blood pressure , A Diphenhydramine (antihistamine ) reinforces antipyretic action of metamizole and reduces swelling of the mucosa . All this allows you to increase heat transfer and make the action metamizole more pronounced.
The indisputable advantage of such a composition is that it can be used in situations where the patient cannot take a pill (for example, in case of impaired consciousness or indomitable vomiting).
Dosage of Analgin, Papaverine And diphenhydramine depends on the age and weight of the patient. In the right amount, the drugs quickly bring down the heat, but if the inflammatory process has just begun to progress, the effect will last only for 3-4 hours, and after this time the temperature will begin to rise again.
An injection of Analgin with Dimedrol from the temperature is done in the gluteal muscle. The mixture can be used no more than once every six hours.
Contraindications to the introduction of "troychatka":
- allergy on the drug that is part of the lytic mixture;
- abdominal pain due to high temperature (with appendicitis the use of a lytic mixture can cause serious harm).
To check availability allergies a drop of solution is injected under the lower eyelid to the patient. The use of triad is categorically contraindicated if the patient has redness or pain.
Also, you should not give an injection if, during the last four hours, when trying to bring down the temperature, the drugs included in the mixture were used (the risk of overdose is high).
It should be noted that the "troychatka" is a universal first aid for a sufficiently large number of pathologies (including trauma and surgical patients). In particular, in an ambulance and in a therapeutic hospital, it is used for relief of hypertensive crisis .
The dose of a 50% solution of Analgin for the preparation of a lytic mixture is selected at the rate of 10 mg / kg. 1% solution diphenhydramine take at the rate of 0.4 ml for each full year of a child's life (children under one year old should take the minimum dose - 0.4 ml).
Dose calculation Papaverine carried out taking into account the age of the child. For a child up to a year, 0.1 ml of the drug is sufficient; for older children, the minimum dose should be multiplied by the number of full years.
To prepare a lytic mixture for adults and adolescents over fifteen years of age with a body weight of 60 kg, 2 ml of Analgin, 2 ml Papaverine and 1 ml diphenhydramine .
For every next 10 kg of weight, a tenth of the indicated standard dose of each of the substances must be added.
Analgin is sometimes added to talkers for treatment acne . To prepare the medicine, you should mix the powdered tablets Levomycetin , Nystatin and Analgin (four of each drug) with the contents of one sachet streptocide and dilute the resulting mixture with one hundred grams of vodka or - for sensitive skin - water.
Symptoms of an overdose of Analgin appear as:
The possibility of developing hemorrhagic syndrome , acute agranulocytosis , hepatic And acute renal failure .
The lethal dose in tablets is from 15 to 20 grams.
Treatment: gastric lavage (the procedure is carried out using a probe), induction of vomiting, the use of saline laxatives and enterosorbents , alkalization of urine, conduction forced diuresis . In the future, symptomatic therapy is aimed at the regulation and maintenance of impaired functions of vital organs.
Effect metamizole amplify caffeine , codeine , barbiturates , H2-antihistamines. Propranol helps to slow down the inactivation of the substance.
The use of Analgin in combination with thiamazole And sarcolysin may lead to the development leukopenia . In combination with tranquilizers and sedatives, the analgesic effect is enhanced metamizole .
Allopurin , oral contraceptives And tricyclic antidepressants disrupt the metabolism of the substance and increase its toxicity.
Simultaneous use with NSAIDs or analgesics-antipyretics provokes mutual enhancement of toxicity, with derivatives phenothiazine - pronounced increase in body temperature.
In combination with myelotoxic drugs increased hematotoxicity metamizole , inducers of microsomal liver enzymes (for example, phenylbutazone ) weaken the effect of the drug.
Metamizole increases activity hypoglycemic agents for oral use, Indomethacin , GC and indirect anticoagulants displacing them from their association with blood proteins. Decreases plasma concentration cyclosporine .
Application penicillin , colloidal blood substitutes and radiopaque substances during treatment with Analgin is contraindicated.
Tablets are released without a prescription. A prescription is required to purchase suppositories and injection solution.
Recipe in Latin (intramuscular injection of a solution for a child of 2 years old):
S. 0.2 ml / m (0.1 ml / year of life).
Analgin solution and tablets should be stored at a temperature of 15-25 ° C, candles - at a temperature not exceeding 15 ° C.
Shelf life of tablets - five years, solution and suppositories - three years.
Metamizole is a derivative of a five-membered heterocyclic lactam pyrazolone , non-narcotic pain reliever .
The gross formula of the substance is C13H16N3NaO4S.
According to the State Pharmacopoeia, the substance has the form of a white or slightly yellowish crystalline powder, which quickly decomposes in the presence of moisture. Easily soluble in water and difficult - in ethanol. It is practically impossible to dissolve the powder in chloroform, ether and acetone.
Wikipedia states that for the first time metamizole was synthesized by the German organic chemist L. Knorr in 1920.
Released during biotransformation metamizole the active metabolite may color urine red.
Enthusiast chemists Analgin s Hydroperite are used to make a "chimney". To do this, the components are taken in a ratio of 3: 1 and ground into powder in different (this is very important!) Containers.
When working with reagents, gloves should be worn (when grinding different preparations, different gloves are worn so that the particles Hydroperita and Analgin did not detonate in the hands), and at the end of the work - wash your hands thoroughly.
After crushing the tablets, powders from different containers are poured into one jar and mixed. The reaction starts at a temperature of 25-30°C.
Synonyms: Baralgin , Analgin Ultra , Optalgin .
Analogues with a similar mechanism of action: Acophilus , Antipyrine , Bralangin , Pentabufen , Revalgin , Spazmolgon , Tetralgin .
Analgin is used under the condition that other therapeutic measures are ineffective.
Candles are prescribed after a year, tablets - from ten years. The solution can be used in children of the first year of life (the route of administration depends on the age of the child).
As a rule, in young children with febrile conditions, rectal suppositories are most often used. This method of administration provides a faster entry of the active substance into the blood and at the same time eliminates its negative effect on the gastrointestinal mucosa.
At a temperature that is poorly controlled by other means, parenteral administration is indicated. metamizole sodium in combination with antispasmodics And antihistamines .
Taking a pill for fever and pain, it is swallowed whole, without chewing, and washed down with a large (about 200 ml) volume of liquid.
If the drug is used to reduce fever, a single dose for patients under the age of fourteen is 10 mg / kg, if for pain relief - from 8 to 16 mg / kg.
For adolescents over fifteen years of age, the dosage in tablets at a time is up to 1 g metamizole (two tablets). If this does not achieve the desired effect, the highest single dose can be taken three more times during the day. The permissible upper limit of the daily dose is 2 g.
10 mg/kg is usually sufficient to reduce fever in children. metamizole .
In children under the age of fourteen, a single dose varies from 50 to 900 mg (or from 8 to 16 mg / kg). The dose and route of administration of the drug is determined depending on the age of the patient.
A single dose for adolescents weighing 46 to 53 kg is 400 to 900 mg (0.8 to 1.8 ml of solution). For adolescents weighing more than 53 kg, Analgin is prescribed in the same dosage as for adults.
The use of a dose exceeding 1 g is associated with the risk of developing hypotensive reactions .
Candles are administered rectally. The daily dose for children from 12 months to three years is one suppository of 100 mg. Children 4-7 years old can enter two suppositories of 100 mg during the day (first one suppository is administered, and after 4-6 hours, if necessary, the second) or one suppository of 250 mg.
Children 8-14 years old during the day, 1-2 suppositories of 250 mg are administered (one at a time, with an interval of 4-6 hours between injections).
After using the drug, the child should remain in the supine position for another half an hour.
The duration of treatment depends on the clinical situation and usually ranges from 1 to 3 days.
The use of Analgin in combination with alcohol enhances the effects (in particular, sedative) of the latter.
There are no sufficient data on the use of Analgin during pregnancy. The safety category for the fetus in accordance with the FDA classification has not been established.
Absolute contraindications for use are the first three and the last one and a half months of pregnancy. In the second trimester, use is possible based on the results of a risk / benefit assessment.
During lactation, the use of the drug is contraindicated. In exceptional cases, feeding is resumed 48 hours after the administration of the solution / taking the tablet.
Analgin is a time-tested universal, potent and very affordable anesthetic , which helps well from the head, from the pain that occurs during menstruation, rheumatism , neuralgia And arthralgia .
Analgin
International non-proprietary name
Metamizole sodium
Dosage form
Tablets 500 mg
Compound
One tablet contains
active substance - metamizole sodium 500.0 mg,
Excipients: potato starch, talc, anhydrous colloidal silicon dioxide (aerosil), calcium stearate.
ABOUTscripture
Tablets of white or slightly yellowish color, flat-cylindrical shape with a chamfer, with a risk on one side, on the other side there is a company logo in the form of a cross.
Pharmacotherapeutic group
Analgesics. Analgesics - antipyretics others. Pyrazolones.
Metamizole sodium
ATX code N02BB02
Pharmacological properties
Pharmacokinetics
After oral administration, metamizole sodium is rapidly absorbed and hydrolyzed in the gastrointestinal tract to form the active metabolite 4-methyl-amino-antipyrine, which, after absorption, is metabolized to 4-formyl-amino-antipyrine and other metabolites. The effective concentration of the total metabolites of analgin is 10 μg / ml and is reached 20-40 minutes after ingestion, the maximum concentration is reached 2 hours after ingestion. In patients with cirrhosis of the liver, the half-life of 4-N-methylaminoantipyrine increased three times and was about 10 hours.
The active metabolites of metamizole sodium are reversibly bound to plasma proteins by about 50%. The largest part of the dose is excreted in the urine in the form of metabolites.
Pharmacodynamics
Analgin has an analgesic, antipyretic and weak anti-inflammatory effect. It is a derivative of pyrazolone.
The mechanism of action is associated with inhibition of the activity of cyclooxygenase types I and II. As a result, the reactions of the arachidonic cascade of eicosanoid synthesis are blocked and the formation of prostaglandins PgE2, PgF2, bradykinin is disrupted. In the nuclei of the antinociceptive system, analgin enhances the release of kynurenic acid, which inhibits the conduction of pain impulses (due to the effect on NMDA receptors).
It prevents the conduction of pain impulses from extra- and proprioceptive receptors along the Gaulle and Burdach bundles, increases the excitability threshold of the pain centers of the thalamus. At the same time, it enhances heat transfer, reduces the activity of the thermoregulatory center of the hypothalamus.
Analgin has a weak anti-inflammatory effect, slightly affects the water-salt metabolism (sodium and water retention) and the mucosa of the gastrointestinal tract. It has an antispasmodic effect on the smooth muscles of the urinary and biliary tract.
Indications for use
Pain syndrome of various etiologies, moderate and severe
intensity resistant to other treatment
Feverish syndrome in acute infectious and inflammatory
diseases resistant to other treatments
Dosage and administration
The drug is taken orally, after a meal. The tablets should be taken with a sufficient amount of water.
Adults and children over 15 years of age are prescribed 250-500 mg (½-1 tablet) 2-3 times a day.
Maximum doses for adults: single - 1 g (2 tablets), daily - no more than 3 g (6 tablets).
The duration of admission is not more than 5 days when prescribed as an anesthetic and not more than 3 days as an antipyretic.
An increase in the daily dose of the drug or the duration of treatment is possible only under medical supervision.
Side effects
Rarely
Nausea, vomiting, anorexia, epigastric pain, flatulence,
constipation, diarrhea
Headache, dizziness, agitation, irritability
Allergic reactions (skin rash, itching, angioedema),
erythema multiforme exudative (Stevens-Johnson syndrome),
toxic epidermal necrolysis (Lyell's syndrome),
bronchospastic syndrome, anaphylactic shock
Paresthesia, tinnitus, blurred vision, tremor, depression
Agranulocytosis, leukopenia, anemia, thrombocytopenia (with prolonged
application)
Arterial hypotension, cardiac arrhythmias
Oliguria, anuria, proteinuria, impaired renal function,
interstitial nephritis
Contraindications
Hypersensitivity to analgin, other derivatives
pyrazolone (phenylbutazone, tribuzone) or other auxiliary
drug substances
Glucose-6-phosphate dehydrogenase deficiency
Liver and/or kidney failure
Inhibition of hematopoiesis (agranulocytosis, cytotoxic or
infectious neutropenia), anemia, leukopenia
Peptic ulcer of the stomach and duodenum, gastrointestinal
intestinal bleeding
Asthma attacks, urticaria, history of acute rhinitis,
associated with the use of acetylsalicylic acid or other
non-steroidal anti-inflammatory drugs
Children's age up to 15 years
Pregnancy and lactation
Drug Interactions
With simultaneous use with other analgesics, antipyretics and non-steroidal anti-inflammatory drugs, mutual enhancement of toxic effects is possible.
The action of Analgin is enhanced when used together with barbiturates, codeine, H2-blockers of histamine receptors, anaprilin (due to slowing down the inactivation of the drug).
Increases the risk of developing leukopenia when used together with thiamazole and cytostatic agents.
Analgin displaces oral hypoglycemic agents from their association with blood plasma proteins and, thereby, increases their effect.
It enhances the activity of indirect anticoagulants, glucocorticosteroids and indomethacin due to their displacement from the connection with plasma proteins.
Analgin enhances the sedative effect of ethyl alcohol.
Analgin lowers the concentration of cyclosporine A in the blood plasma.
With simultaneous use with phenothiazine derivatives, severe hyperthermia may develop.
Tricyclic antidepressants, combined oral contraceptives and allopurinol slow down the metabolism of Analgin and increase its toxicity, sedatives and anxiolytics enhance the analgesic effect of Analgin.
With simultaneous use with myotropic antispasmodics (drotaverine, papaverine, pitofenone) and m-anticholinergics (fenpiverinium bromide, platifillin, atropine), there is a mutual enhancement of the analgesic, antispasmodic and antipyretic activity of this combination.
Caffeine enhances the effect of the drug.
With simultaneous use with inducers of microsomal liver enzymes, the effectiveness of Analgin may decrease.
special instructions
Long-term use of Analgin
If it is necessary to regularly use Analgin for more than 5 days, the picture of peripheral blood should be monitored weekly.
Use in individuals with pathology of the cardiovascular system
Careful monitoring of hemodynamics is necessary, especially in patients with systolic blood pressure levels below 100 mm Hg. Art. or with circulatory instability (eg, myocardial infarction, multiple trauma, incipient shock), with a history of kidney disease (pyelonephritis, glomerulonephritis), as well as in people with alcohol dependence.
Agranulocytosis
In the event of an unexpected deterioration in the general condition of the patient during treatment with Analgin, manifested by fever, inflammation of the mucous membranes of the oral cavity and pharynx (necrotizing stomatitis, purulent-necrotic tonsillitis), nose (sinusitis), increased ESR, the drug should be stopped immediately, because . these symptoms may be associated with the development of agranulocytosis.
Excretion with urine of biotransformation products Analgin can cause red staining of urine, which has no clinical significance and disappears after discontinuation of the drug.
Application in pediatrics
Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
Receiving Analgin does not affect the ability to drive vehicles or potentially dangerous mechanisms, but care should be taken with prolonged use.
Overdose
Symptoms: nausea, vomiting, epigastric pain, hypothermia, lowering blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, impaired consciousness, delirium, acute liver and / or kidney failure, convulsions, paralysis of the respiratory muscles, agranulocytosis.
Treatment: withdrawal of the drug, gastric lavage, taking saline laxatives and activated charcoal to prevent absorption of the drug in the stomach and intestines, symptomatic therapy aimed at maintaining vital functions. Carrying out forced diuresis and the introduction of sodium bicarbonate in order to alkalinize urine accelerate the excretion of the drug. There is no specific antidote for metamizole sodium. The main metabolite of metamizole (4-methylaminoantipyrine) can be removed by hemodialysis, hemofiltration, hemoperfusion and plasmapheresis. With the development of a convulsive syndrome - intravenous administration of diazepam and high-speed barbiturates.
Release form and packaging
10 tablets in a blister pack made of PVC film and aluminum foil.
Blisters are placed in cardboard boxes.
The approved instructions for medical use in the state and Russian languages are included in the group package according to the number of packages.
Storage conditions
Store in a dry, dark place at a temperature not exceeding 30°C.
Keep out of the reach of children!
Shelf life
After the expiration date, the drug should not be used.
Terms of dispensing from pharmacies
Over the counter
Manufacturer
JSC "Khimfarm", Kazakhstan,
Shymkent, st. Rashidova, b / n, tel / f: 560882
Registration certificate holder
JSC Chimpharm, Kazakhstan
Address of the organization hosting on the territory of the Republic of Kazakhstan claims from consumers on the quality of products (goods)
JSC "Khimfarm", Shymkent, KAZAKHSTAN,
st. Rashidova, b / n, tel / f: 560882
Phone number 7252 (561342)
Fax number 7252 (561342)
E-mail address [email protected]
Analgin
International non-proprietary name
Metamizole sodium
Dosage form
Tablets 500 mg
Compound
One tablet contains:
active substance- metamizole sodium 500.0 mg,
Excipients: sucrose, talc, potato starch, calcium stearate.
Description
Tablets are white or white with a slightly yellowish tinge of color, flat-cylindrical shape with a chamfer and a risk.
Farmacotherapeutic group
Other analgesics-antipyretics. Pyrazolones. Metamizole sodium
ATX code N02BB02
Pharmacological properties
Pharmacokinetics
When taken orally, it is rapidly and completely absorbed. There is no unchanged metamizole in the blood.
Excreted by the kidneys as metabolites. Metabolites are excreted in breast milk. The action develops in 20-40 minutes and reaches a maximum after 2 hours. The maximum concentration is reached 1-1.5 hours after parenteral administration. The half-life is about 7 hours. Metabolites are completely excreted in the urine, 71% of the administered dose is found in the range from 0 to 24 hours, 18% - from 24 to 48 hours.
Pharmacodynamics
Analgin has an analgesic, antipyretic and weak anti-inflammatory effect. It is a derivative of pyrazolone. The mechanism of action is associated with inhibition of the activity of cyclooxygenase types I and II. As a result, the reactions of the arachidonic cascade of eicosanoid synthesis are blocked and the formation of prostaglandins PgE2, PgF2α, their endoperoxides, and bradykinin is disrupted. In the nuclei of the antinociceptive system, analgin enhances the release of kynurenic acid, which inhibits the conduction of pain impulses (due to the effect on NMDA receptors).
It prevents the conduction of pain impulses from extra- and proprioceptive receptors along the Gaulle and Burdach bundles, increases the excitability threshold of the pain centers of the thalamus. At the same time, it enhances heat transfer, reduces the activity of the hypothalamic thermosetting center.
Indications for use
Pain syndrome, mild or moderate (headache, toothache, neuralgia, myalgia, dysmenorrhea, postoperative pain)
Fever in infectious and inflammatory diseases
Dosage and administration
1 tablet 2-3 times a day after meals. The maximum single dose is 1 g, the daily dose is 3 g. Adults and children over 15 years of age are prescribed 250-500 mg (½-1 tablet) 2-3 times a day.
The duration of admission is not more than 5 days when prescribed as an anesthetic and not more than 3 days as an antipyretic.
Side effects
Rarely
Nausea, vomiting, anorexia, epigastric pain, flatulence,
constipation, diarrhea
Headache, dizziness, agitation, irritability
Allergic reactions (skin rash, itching, angioedema),
erythema multiforme exudative (Stevens-Johnson syndrome),
toxic epidermal necrolysis (Lyell's syndrome),
bronchospastic syndrome, anaphylactic shock
Paresthesia, tinnitus, blurred vision, tremor, depression
Agranulocytosis, leukopenia, anemia, thrombocytopenia (with prolonged
application)
Arterial hypotension, cardiac arrhythmias
Oliguria, anuria, proteinuria, impaired renal function,
interstitial nephritis
Contraindications
Hypersensitivity to analgin, other derivatives
pyrazolone (phenylbutazone, tribuzone) or other auxiliary
drug substances
Glucose-6-phosphate dehydrogenase deficiency
Liver and/or kidney failure
Inhibition of hematopoiesis (agranulocytosis, cytotoxic or
infectious neutropenia), anemia, leukopenia
Peptic ulcer of the stomach and duodenum, gastrointestinal
intestinal bleeding
Asthma attacks, urticaria, history of acute rhinitis,
associated with the use of acetylsalicylic acid or other
non-steroidal anti-inflammatory drugs
Children's age up to 15 years
Pregnancy and lactation
Drug Interactions
With simultaneous use with other analgesics, antipyretics and non-steroidal anti-inflammatory drugs, mutual enhancement of toxic effects is possible.
The action of Analgin is enhanced when used together with barbiturates, codeine, H2-blockers of histamine receptors, anaprilin (due to slowing down the inactivation of the drug).
Increases the risk of developing leukopenia when used together with thiamazole and cytostatic agents.
Analgin displaces oral hypoglycemic agents from their association with blood plasma proteins and, thereby, increases their effect.
It enhances the activity of indirect anticoagulants, glucocorticosteroids and indomethacin due to their displacement from the connection with plasma proteins.
Analgin enhances the sedative effect of ethyl alcohol.
Analgin lowers the concentration of cyclosporine A in the blood plasma.
With simultaneous use with phenothiazine derivatives, severe hyperthermia may develop.
Tricyclic antidepressants, combined oral contraceptives and allopurinol slow down the metabolism of Analgin and increase its toxicity, sedatives and anxiolytics enhance the analgesic effect of Analgin.
With simultaneous use with myotropic antispasmodics (drotaverine, papaverine, pitofenone) and m-anticholinergics (fenpiverinium bromide, platifillin, atropine), there is a mutual enhancement of the analgesic, antispasmodic and antipyretic activity of this combination.
Caffeine enhances the effect of the drug.
With simultaneous use with inducers of microsomal liver enzymes, the effectiveness of Analgin may decrease.
special instructions
Long-term use of Analgin
If it is necessary to regularly use Analgin for more than 5 days, the picture of peripheral blood should be monitored weekly.
Use in individuals with pathology of the cardiovascular system
Careful monitoring of hemodynamics is necessary, especially in patients with systolic blood pressure levels below 100 mm Hg. Art. or with circulatory instability (eg, myocardial infarction, multiple trauma, incipient shock), with a history of kidney disease (pyelonephritis, glomerulonephritis), as well as in people with alcohol dependence.
Agranulocytosis
In the event of an unexpected deterioration in the general condition of the patient during treatment with Analgin, manifested by fever, inflammation of the mucous membranes of the oral cavity and pharynx (necrotizing stomatitis, purulent-necrotic tonsillitis), nose (sinusitis), increased ESR, the drug should be stopped immediately, because . these symptoms may be associated with the development of agranulocytosis.
Excretion with urine of biotransformation products Analgin can cause red staining of urine, which has no clinical significance and disappears after discontinuation of the drug.
Application in pediatrics
Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
Receiving Analgin does not affect the ability to drive vehicles or potentially dangerous mechanisms, but care should be taken with prolonged use.
Overdose
Symptoms: nausea, vomiting, stomach pain, hypothermia, lowering blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, impaired consciousness, delirium, acute liver and / or kidney failure, convulsions, paralysis of the respiratory muscles, agranulocytosis.
Treatment: withdrawal of the drug, gastric lavage, taking saline laxatives and activated charcoal to prevent absorption of the drug in the stomach and intestines, symptomatic therapy aimed at maintaining vital functions. Carrying out forced diuresis and the introduction of sodium bicarbonate in order to alkalinize urine accelerate the excretion of the drug. There is no specific antidote for metamizole sodium. The main metabolite of metamizole (4-methylaminoantipyrine) can be removed by hemodialysis, hemofiltration, hemoperfusion and plasmapheresis. With the development of a convulsive syndrome - intravenous administration of diazepam and high-speed barbiturates.
Active substance
Metamizole sodium
Dosage form
pills
Manufacturer
Pharmstandard, Russia
Compound
1 tablet contains:
active ingredient: metamizole sodium (analgin) 500 mg
excipients: sucrose (sugar), potato starch, talc, calcium stearate.
pharmachologic effect
Analgin non-selectively blocks cyclooxygenase and reduces the formation of prostaglandins from arachidonic acid, prevents the conduction of extra-painful and proprioceptive impulses.
Analgin has a mild anti-inflammatory effect, causing a small effect on water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa.
It has an antispasmodic effect on the smooth muscles of the urinary and biliary tract. The action develops 20-40 minutes after ingestion.
Pharmacokinetics
It is well and quickly absorbed in the gastrointestinal tract, which ensures the rapid development of the clinical effect. When taken in therapeutic doses, it passes into breast milk.
The maximum plasma concentration is reached 1-1.5 hours after ingestion.
In the intestinal wall, it is hydrolyzed to form the active metabolite, 4-methyl-amino-antipyrine, which in turn is metabolized to 4-formyl-amino-antipyrine and other metabolites.
The level of binding of the active metabolite to proteins is 50-60%.
Excretion of metabolites passes through the kidneys. In addition, metabolites are excreted in breast milk.
Indications
- pain syndrome (mild and moderate): incl. headache, migraine, toothache, neuralgia, myalgia, radicular syndrome, algomenorrhea; with renal, hepatic and biliary colic (in combination with antispasmodics),
- to reduce pain after surgical and diagnostic interventions,
- elevated body temperature with "colds" and other infectious and inflammatory diseases. The expediency of using the drug is decided in each case, depending on the severity, nature and tolerance of fever.
Contraindications
- hypersensitivity to pyrazolone derivatives (propyphenazone, phenazone or phenylbutazone);
- bronchial asthma induced by taking acetylsalicylic acid, salicylates or other non-steroidal anti-inflammatory drugs (NSAIDs);
- bronchial obstruction, rhinitis, urticaria, provoked by taking acetylsalicylic acid or other NSAIDs (including history), condition after CABG;
- oppression of hematopoiesis (agranulocytosis, cytostatic or infectious neutropenia);
- severe violations of the liver or kidneys;
- hepatic porphyria;
- confirmed hyperkalemia, erosive and ulcerative changes in the mucous membrane of the stomach and duodenum, active gastrointestinal bleeding, inflammatory bowel disease, anemia, leukopenia;
- hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase.
Side effects
In therapeutic doses, the drug is usually well tolerated.
When using Analgin tablets in some patients, adverse reactions may occur:
- allergic reactions (skin rash, Quincke's edema; rarely - anaphylactic shock);
- with prolonged use, leukopenia may occur, rarely agranulocytosis.
With a tendency to bronchospasm, provoking an attack is possible.
Possible impaired renal function.
Interaction
Due to the high likelihood of developing pharmaceutical incompatibility, it cannot be mixed with other drugs in the same syringe.
Simultaneous use of analgin with other non-narcotic analgesics can lead to mutual enhancement of toxic effects.
Tricyclic antidepressants, oral contraceptives, allopurinol disrupt the metabolism of dipyrone in the liver and increase its toxicity.
Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the action of analgin.
The simultaneous use of analgin with cyclosporine reduces the level of the latter in the blood.
Sedatives and tranquilizers enhance the analgesic effect of analgin.
How to take, course of administration and dosage
Inside, after meals, adults and children over 14 years of age are prescribed 250-500 mg 2-3 times a day, the maximum single dose is 1000 mg, the daily dose is 3000 mg.
Children 8-14 years old are prescribed 250 mg (1/2 tablet) 2-3 times a day.
The duration of admission without consulting a doctor is not more than 5 days.
Overdose
In case of overdose, you should consult your doctor.
The following symptoms may appear: nausea, vomiting, stomach pain, oliguria, hypothermia, lowering blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and / or liver failure, convulsions, paralysis of the respiratory muscles.
Treatment: symptomatic. There is no specific antidote for metamizole sodium. In the conditions of a medical institution - carrying out forced diuresis, hemodialysis, with the development of a convulsive syndrome - intravenous administration of diazepam and high-speed barbiturates.
Special Instructions
Hypersensitivity reactions may develop in patients suffering from bronchial asthma and hay fever.
With prolonged use (more than 7 days), it is necessary to control the picture of peripheral blood. Against the background of taking metamizole sodium, the development of agranulocytosis is possible, and therefore, if an unmotivated rise in temperature, chills, sore throat, difficulty swallowing, stomatitis, erosive and ulcerative lesions of the oral cavity, vaginitis or proctitis are detected, immediate withdrawal of the drug is necessary.
Do not use to relieve acute pain in the abdomen (until the causes are clarified).
in a contour non-cell or cell package of 10 pcs.; in a cardboard pack 1, 2, 3 or 5 packs.
Description of the dosage form
Tablets of white or slightly yellowish color, ploskotsilindrichesky, with risk and a facet, bitterish taste.
Pharmacodynamics
Metamizole sodium is a derivative of pyrazolone. It has analgesic, antipyretic and weak anti-inflammatory effects, the mechanism of which is associated with inhibition of PG synthesis. Pharmacological action develops 20-40 minutes after taking the drug and reaches a maximum after 2 hours.
Analgin: Indications
Pain syndrome of various etiologies:
headache;
migraine pain;
toothache;
neuralgia;
algomenorrhea;
postoperative pain;
renal and biliary colic (in combination with antispasmodics);
febrile conditions in infectious and inflammatory diseases.
Analgin: Contraindications
hypersensitivity to pyrazolone derivatives (butadione, tribuzone);
bronchial asthma;
diseases accompanied by bronchospasm;
"aspirin asthma";
oppression of hematopoiesis (agranulocytosis, neutropenia, leukopenia);
severe violations of the liver or kidneys;
blood diseases;
hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase;
pregnancy (especially in the first trimester and in the last 6 weeks);
lactation period.
With caution - infancy (up to 3 months).
Use during pregnancy and lactation
Contraindicated in pregnancy (especially in the first trimester and in the last 6 weeks). At the time of treatment should stop breastfeeding.
Dosage and administration
inside, adults - 1 tab. 2-3 times a day after meals. The maximum single dose is 1 g (table 2), daily dose is 3 g (table 6). With prolonged (more than a week) use of the drug, it is necessary to control the pattern of peripheral blood and the functional state of the liver.
Children are prescribed 5–10 mg/kg of body weight 3–4 times a day for no more than 3 days (after crushing the tablet).
Do not use (without consulting a doctor) for more than 3 days when prescribed as an antipyretic and for more than 5 days when prescribed as an anesthetic.
Analgin side effects
Allergic reactions: skin rash, angioedema; rarely - anaphylactic shock, toxic epidermal necrolysis (Lyell's syndrome), in rare cases - Stevens-Johnson syndrome.
With prolonged use, leukopenia, thrombocytopenia, agranulocytosis may occur.
With a tendency to bronchospasm, provoking an attack is possible; decrease in blood pressure.
Possible impaired renal function, oliguria, anuria, proteinuria, interstitial nephritis, urine staining red due to the release of a metabolite.
About all side (unusual) effects, incl. not listed above, you should inform your doctor and stop taking the drug.
Overdose
Symptoms: with prolonged use of the drug (more than 7 days) in high doses - nausea, vomiting, gastralgia, oliguria, hypothermia, decreased blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, delirium, impaired consciousness, agranulocytosis, hemorrhagic syndrome, acute renal and / or liver failure, convulsions, paralysis of the respiratory muscles.
Treatment: induce vomiting, do gastric lavage, take saline laxatives, activated charcoal. In the conditions of a medical institution - carrying out forced diuresis, hemodialysis, with the development of a convulsive syndrome - in / in the introduction of diazepam and barbiturates.
Interaction
Simultaneous use of Analgin with other non-narcotic analgesics can lead to mutual enhancement of toxic effects.
Tricyclic antidepressants, oral contraceptives, and allopurinol interfere with hepatic metabolism of metamizole and increase its toxicity.
Barbiturates and phenylbutazone weaken the action of analgin.
Analgin enhances the effects of alcoholic beverages.
Radiopaque agents, colloidal blood substitutes and penicillin should not be used during treatment with metamizole.
Metamizole, displacing oral hypoglycemic drugs, indirect anticoagulants, corticosteroids and indomethacin from the connection with the protein, increases their activity.
The simultaneous use of Analgin with cyclosporine reduces the level of the latter in the blood. Thiamazole and sarcolysin increase the risk of leukopenia. The effect is enhanced by codeine, propranolol (slows down inactivation).
Sedatives and tranquilizers enhance the analgesic effect of analgin.
special instructions
Hypersensitivity reactions may develop in patients suffering from bronchial asthma and hay fever.
With prolonged use (more than 7 days), it is necessary to control the picture of peripheral blood.
Do not use to relieve acute pain in the abdomen (until the causes are clarified).
In the treatment of children under 5 years of age and patients receiving cytostatic agents, taking metamizole sodium should be carried out only under the supervision of a physician.
Special care is required when prescribing to patients who abuse alcoholic beverages.
For children and adolescents under 18 years of age, use only as directed by a doctor.