Vitamin C in ampoules is used intramuscularly And intravenously.

1. intramuscular injection do deep into the thickness of the muscle, preheating the solution to room temperature.
2. Intravenous vitamin C can be administered by jet for 2-3 minutes, and drip, at a rate of 25-30 drops per minute. As a basis for administration, 50-100 ml of a 5% glucose solution or 0.9% saline is used.
3. Adults and children over 12 years old prescribe 50-150 mg of ascorbic acid per day. In acute intoxication, the dose can be raised to 500 mg.
4. Children under 12 vitamin C is prescribed at a dose of 5-7 mg / kg per day.

Ascorbic acid in ampoules for hair

In addition to the traditional use of vitamin C in ampoules, it is used to normalize the condition of the hair. When applied topically, ascorbic acid stimulates blood circulation in the hair follicles.

It makes hair stronger, stimulates their growth, gives shine and silkiness. Locally vitamin C is used in the form of masks.

1. For oily hair you need to mix 2 ml of ascorbic acid, an egg, two tablespoons of cognac and honey. Apply for 15 minutes, then rinse with shampoo.
2. For dry hair you need to mix 2 ml of vitamin C, and apply two tablespoons of kefir, burdock and castor oils in the same way.

Masks should be used no more than 3-4 times a month, in order to avoid overdrying the hair. After the procedure, it is undesirable to dry the curls with a hairdryer, it is better to let them dry in the air.

Vitamin C washes away dark dye from hair - girls who have done dyeing should be careful.

Compound

1 ml of the drug contains ascorbic acid 50 or 100 mg.

Additional components: water for injection, sodium metabisulfite, sodium bicarbonate, disodium edetate.

Release form

Ascorbic acid is produced in ampoules as a solution for injection, 50 or 100 mg per ml. The package contains 10 ampoules, with a volume of 1 or 2 ml.

Vitamin C preparations

pharmachologic effect

Ascorbic acid- an antioxidant that takes part in redox reactions, the metabolism of carbohydrates, aromatic amino acids and thyroxine. Necessary for the normal operation of such systems:
Cardiovascular and circulatory

• necessary for normal blood clotting;
• inhibits hyaluronidase, regulating capillary permeability;
• participates in the synthesis of hemoglobin;
• helps cleanse the blood of toxins.

Skin and mucous membranes

• accelerates wound healing;
• controls the synthesis of collagen, which is responsible for skin elasticity;
• protects the skin from premature aging;
• increases skin resistance to infectious diseases.

immune system

• increases nonspecific resistance (resistance) of the body;
• enhances humoral (antibodies) and cellular immunity;
• protects lymphocytes from the damaging effects of cross-oxidation;
• activates antioxidants to a biologically available form.

endocrine system

• accelerates the synthesis of thyroid hormones;
• enhances the endocrine function of the pancreas;
• stimulates the synthesis of catecholamines and steroid hormones.

Digestive system

• participates in the synthesis of pepsin and trypsin;
• accelerates the absorption of iron and aluminum compounds;
• stimulates the outflow of bile;
• enhances the detoxification and protein-forming functions of the liver.

Pharmacodynamics and pharmacokinetics

Ascorbic acid is a water-soluble vitamin, the relationship with blood plasma peptides is 26-28%. The body can store no more than 1.5 g of pure substance, which is consumed within 8-14 hours. Most vitamin C enters the endocrine glands, parenchymal organs and skeletal muscles.

Utilization of ascorbic acid occurs in the liver, it is excreted in the urine in the form of oxalate, when high doses are consumed - unchanged. Ethyl alcohol and nicotine accelerate the destruction of vitamin C.

Indications for use

Ascorbic acid intramuscularly

• capillary toxicosis;
• recovery period after infections, poisoning and operations;
• the period of preparation for sports competitions or hard physical labor;
• gastritis with low acidity;
• non-healing skin wounds and bone fractures.

Ascorbic acid intravenously

• vitamin C deficiency;
• decreased adrenal function;
• as a universal antidote for intoxication;
• poor blood clotting and traumatic bleeding;
• compensation of systemic alkalization of the body.

Vitamin C in ampoules - contraindications

Contraindications

• allergy to the components of the solution;
• high blood clotting;
• predisposition to thrombophlebitis and thromboembolism;
• diabetes;
• urolithiasis disease;
• acute renal failure.

Side effects

Side effects

• increased blood pressure;
• suppression of insulin production;
• blood clots, decreased hemoglobin levels;
• allergic reactions up to anaphylactic shock;
• disruption of the glomerular apparatus of the kidneys;
• accumulation in the body of zinc and copper, causing nervous disorders (insomnia, overexcitability);
• the appearance of stones in the kidneys and urinary tract.

special instructions

Pregnant and lactating women are contraindicated in the use of ascorbic acid in doses above 100-120 mg. Vitamin C enters the placental circulation and is excreted in milk.

The body of the fetus compensates for the overdose, and reducing the dose can cause a "rollback" syndrome. With it, symptoms similar to scurvy occur - a decrease in muscle tone, bleeding gums, the appearance of hemorrhages on the skin, lethargy and nervousness.

When treated with vitamin C possible misrepresentation of test results- levels of sugar, lactate dehydrogenase, bilirubin, ALT and AST. Ascorbic acid can cause accelerate the growth of malignant tumors.

Interaction

1. Combination with aspirin and sulfonamides can cause the formation of kidney and bladder stones;
2. Vitamin C enhances the absorption of penicillin and tetracycline, increasing their level in the blood;
3. Ascorbic acid reduces activity antidepressants and antithrombotic drugs;
4. Vitamin C reduces the effectiveness of oral contraceptives and increases the rate of ethanol excretion;
5. Simultaneous intake of ascorbic acid and deferoxamine increases the toxicity of iron. These drugs should be used with a difference of at least 2 hours.

Overdose

1. Prolonged overdose ascorbic acid is accompanied by diarrhea, vomiting, skin rash and the formation of stones in the bladder and kidneys.
2. Single overdose causes flatulence, painful abdominal cramps, itching and irritability. In pregnant women, a large dose of vitamin C can lead to miscarriage.

Terms of sale

On prescription.

Storage conditions

In a dark place, out of the reach of children, at a temperature not exceeding 25°C.

Best before date

1 year. It is forbidden to use after the expiration date.

Vitamin C is one of those components that are vital to the body. In large quantities, the vitamin is found in berries and citrus fruits. Pharmacies offer products that resemble yellow sour pills from childhood. Their effectiveness is insignificant, in comparison with intramuscular administration. Ascorbic acid in ampoules instantly penetrates into the circulatory system and beneficial substances are carried throughout the body.

The benefits of ascorbic acid

The substance accelerates recovery and improves the metabolic processes of the human body. White or with a yellow tinge, the powder has a sour taste and is remarkably soluble in water. Thanks to the beneficial qualities of vitamin C, the drug resists various diseases and enhances protective functions. One serving of the product has the following effect:

• strengthens the immune system;
• normalizes cholesterol levels;
• reduces the likelihood of diseases of the respiratory system;
• improves the chemical composition of the blood due to saturation with hemoglobin;
• tones the skin, promotes rapid cell regeneration.

When using ascorbic acid, the exact dosage prescribed by the attending physician should be observed. Otherwise, a number of side effects will occur, including disruption of the digestive system and damage to the stomach walls. Plus, an excessive amount of vitamin C loads the excretory system.

pharmachologic effect

The human body does not produce ascorbic acid on its own, the necessary component enters with food. It takes part in metabolic processes, restoration, oxidation, regeneration, normalization of blood clotting. The presence of vitamin C allows you to show resistance to infections, and the substance improves capillary permeability, strengthens the vascular walls, and reduces the lack of other vitamins.

The agent exhibits an antioxidant effect, which ensures the transport of hydrogen for the absorption of glucose and the successful implementation of important biochemical processes, such as the synthesis of collagen elements and hormones from the steroid group.

Ascorbic acid, when administered intramuscularly, is combined with plasma proteins, already 4 hours after entering the blood, the concentration of the substance reaches its maximum. The component quickly penetrates into tissues along with platelets and leukocytes, accumulating in organs. Absorption is carried out in the small intestine, where the vitamin is transformed into dehydroascorbic acid.

The intestines and kidneys are responsible for the excretion of metabolites, some of it disappears from the body with sweat and breast milk. It is important to consider that alcoholic beverages and tobacco products provoke a change in ascorbic acid. The reserves of the substance in the body are reduced due to its conversion into inactive type metabolites.

When to use

Experts recommend increasing the dose of ascorbic acid in a natural way, that is, through food, but sometimes this is not possible, especially in the winter season. The introduction of ascorbic acid intravenously and intramuscularly is prescribed in such cases:

• elimination of beriberi and hypovitaminosis of ascorbic acid, when oral intake is impossible, and the need for urgent replenishment of the substance is present;
• with problems with the functioning of the digestive system;
• in case of chemical poisoning with gaseous substances, in this case, ascorbic acid normalizes oxidation and restores the internal environment of the body, which is important when removing toxic elements.

With these problems, it is necessary to contact a medical institution, where a specialist draws up an individual treatment plan based on the results of diagnostic measures.

Indications for use

You should pay attention to the first symptoms of hypovitaminosis, which manifest as blanching of the skin, impaired regeneration, weakness, insomnia, weakened immunity, bleeding gums. Vitamin C in ampoules for injection is used in the following situations:

• prolonged hypothermia of the body;
• irrational nutrition;
• in the presence of dangerous diseases, such as scurvy and tuberculosis;
• prolonged physical and mental stress;
• recovery period after surgery or prolonged treatment;
• therapy against dependence on alcohol and tobacco products;
• heavy bleeding;
• intoxication of the body;
• liver disease;
• diathesis of hemorrhagic type;
• problems with the functioning of the respiratory system;
• dystrophy.

In each case, the dosage and regularity of administration is determined individually. Sometimes you can get away with oral administration, but in certain cases, injections are prescribed.

special instructions

Prolonged lack of ascorbic acid causes irreversible changes in the body. These include:

• the occurrence of secondary infectious diseases;
• excessive mobility or loss of teeth;
• the tendency of bones to fracture;
• problems with the work of the digestive, cardiovascular, excretory systems;
• heavy bleeding;
• pain in the muscles and joints, which significantly limits mobility.

Clinical manifestations of deficiency lead to the appointment of vitamin C injections. In order to avoid negative consequences, strict dosage and regularity should be observed during injections. Ascorbic acid is injected into the blood stream (for 2-3 minutes) or drip (25 drops per minute). In the first case, the basis of the agent is a saline solution (0.9%) or a glucose solution (5%), in an amount of 50-100 ml. Droppers with ascorbic acid are used for serious diseases.

Before intramuscular use, the drug is heated to ambient temperature (about 23 degrees), then the syringe is filled and the working solution of ascorbic acid is injected directly into the muscle tissue. For injections, a 5% solution is intended. Adults are prescribed a vitamin intake three times a day, 1-5 ml. In childhood, the dose is reduced to 1 ml. The treatment plan directly depends on the stage of the disease and the condition of the body.

Due to the fact that ascorbic acid leads to the production of corticosteroid hormones, the likelihood of the formation of stones in the kidneys increases. That is why therapy is carried out with regular diagnostics of the adrenal glands, kidneys and pressure in the circulatory system. With an excessive level of iron in the body, the use of the product should be approached with extreme caution. An increase in the content of vitamin C leads to disruption of the pancreas.

Side effects

The use of vitamin C in ampoules requires compliance with certain rules. As a rule, ascorbic acid is perfectly perceived by the body, but a number of factors cause side effects, which include:

1. Lethargy and dizziness, which is a consequence of the rapid introduction of a solution of ascorbic acid.
2. Pain in the area of ​​intramuscular injection.
3. Excessive excitability and frequent migraines in overdose.
4. Increased blood pressure due to impaired capillary permeability.
5. Allergic reactions with individual intolerance to the component.
6. Thrombocytosis, leukocytosis and glucosuria.
7. Insufficiency of the adrenal cortex.

In case of any of these factors, it is necessary to stop taking the drug and consult with your doctor. Otherwise, severe complications and secondary diseases develop. Before injecting vitamin C, you need to make sure that there is no individual intolerance.

Is an overdose possible?

Overdose is a consequence of negligent treatment with ascorbic acid. This often occurs when the patient switches to self-administration or home injection. Therefore, patients are advised not to refuse therapy on an outpatient basis. Signs of overdose are:

• hyperglycemia;
• arterial hypertension;
• thromboembolism;
• increased blood sugar;
• the formation of stones.

These problems arise not only in case of overdose, but also in case of long-term treatment. In any case, you must stop taking the remedy and tell your doctor about the problems that have arisen.

Compatibility with other drugs

Ascorbic acid is not recommended for use with drugs that contain folic acid, iron, vitamin B12. Their combination leads to undesirable consequences, and with long-term therapy, serious side effects and diseases develop.

Contraindications

Ascorbic acid in the form of injections, like any other drug, has some contraindications. According to the instructions, they include:

• individual intolerance to acid;
• diabetes;
• stones in the excretory system;
• blood clotting disorders;
• pregnancy and lactation;
• thrombophlebitis or a tendency to form blood clots.

Catad_pgroup Vitamins and minerals

Ascorbic acid - SOLO pharm - instructions for use

Registration number:

LP-004544-161117

Trade name of the drug:

Ascorbic acid-SOLOpharm

International non-proprietary name:

Ascorbic acid

Dosage form:

solution for intravenous and intramuscular administration

Compound:

1 ml of the drug contains:
active substance: Ascorbic acid 50 mg
Excipients: Sodium bicarbonate 23.85 mg
Sodium sulfite 2 mg
Water for injection up to 1 ml

Description:

Clear colorless or slightly colored liquid.

Pharmacotherapeutic group:

Vitamin.

ATX code:

A11GA01

Pharmacological properties

Pharmacodynamics

Ascorbic acid (vitamin C) is not synthesized in the human body, but comes only with food.
Pharmacological effects: in quantities significantly exceeding the daily requirement (90 mg), it has almost no effect, with the exception of the rapid elimination of symptoms of hypo- and beriberi (scurvy).
Physiological functions: is a coenzyme of some hydroxylation and amidation reactions - transfers electrons to enzymes, providing them with a reducing equivalent. Participates in the reactions of hydroxylation of proline and lysine residues of procollagen with the formation of hydroxyproline and hydroxylysine (post-translational modification of collagen), oxidation of lysine side chains in proteins with the formation of hydroxytrimethyllysine (during the synthesis of carnigin), oxidation of folic acid to folinic acid, drug metabolism in liver microsomes and hydroxylation dopamine to form norepinephrine.
Increases the activity of amidating enzymes involved in the processing of oxytocin, antidiuretic hormone and cholecystokinin. Participates in steroidogenesis in the adrenal glands.
The main role in tissues is participation in the synthesis of collagen, progeoglycans and other organic components.

Pharmacokinetics
Communication with plasma proteins - 25%. Normally, the concentration of ascorbic acid in plasma is approximately 10-20 μg / ml. It easily penetrates into leukocytes, platelets, and then into all tissues: the highest concentration is achieved in the glandular organs, leukocytes, liver and lens of the eye: it penetrates the placenta. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and in blood plasma. In deficient conditions, the concentration of ascorbic acid in leukocytes decreases later and more slowly and is considered as a better criterion for assessing deficiency than the concentration in blood plasma.
It is metabolized mainly in the liver to deoxyascorbic acid and then to oxaloacetic acid and ascorbate-2-sulfate.
Excreted by the kidneys, through the intestines, with sweat, breast milk unchanged and in the form of metabolites.
With the appointment of high doses, the rate of excretion increases dramatically. Smoking and the use of ethanol accelerate the destruction of ascorbic acid (transformation into inactive metabolites), sharply reducing stocks in the body.
Excreted during hemodialysis.

Indications for use

Treatment of hypo- and avitaminosis C (if necessary, rapid replenishment of vitamin C and the impossibility of oral administration).
Clinical situations associated with the need for additional administration of ascorbic acid, including: parenteral nutrition, diseases of the gastrointestinal tract (persistent diarrhea, resection of the small intestine, peptic ulcer, gastrectomy), Addison's disease.
In laboratory practice: for labeling erythrocytes (together with sodium chromate).

Contraindications

Hypersensitivity to the components of the drug. With prolonged use in large doses (more than 500 mg) - diabetes mellitus, hyperoxaluria. nephrourolithiasis, hemochromatosis, thalassemia.
Carefully

Sideroblastic anemia, urolithiasis, deficiency of glucose-6-phosphate dehydrogenase.

Use during pregnancy and during breastfeeding

During pregnancy and during breastfeeding, it is used only if the intended benefit to the mother outweighs the potential risk to the fetus and child.
The minimum daily requirement for ascorbic acid in the II-III trimesters of pregnancy is about 60 mg. It should be borne in mind that the fetus can adapt to the high doses of ascorbic acid that a pregnant woman takes, and then the newborn may develop a "withdrawal" syndrome.
The minimum daily requirement during lactation is 80 mg. A mother's diet containing an adequate amount of ascorbic acid is sufficient to prevent its deficiency in an infant. Theoretically, there is a danger to the child when the mother uses high doses of ascorbic acid (it is recommended not to exceed the daily need for ascorbic acid by the nursing mother).

Dosage and administration

Intramuscularly, intravenously (slowly).
Adults from 100 to 500 mg (2-10 ml of a 5% solution) per day, in the treatment of scurvy - up to 1000 mg per day.
Children - from 100 to 300 mg (2-6 ml of a 5% solution) per day, in the treatment of scurvy - up to 500 mg (10 ml of a 5% solution) per day.
The duration of treatment depends on the nature and course of the disease.
For labeling erythrocytes (together with sodium chromate) - 100 mg of ascorbic acid is injected into a bottle of sodium chromate.

Side effect

From the side of the central nervous system (CNS): with rapid intravenous administration - dizziness, feeling of fatigue; with prolonged use of large doses (more than 1 g) - headache, increased excitability of the central nervous system, insomnia.
From the urinary system: moderate pollakiuria (when using a dose of more than 600 mg / day); with prolonged use of large doses - hyperoxaluria, nephrolithiasis (from calcium oxalate), damage to the glomerular apparatus of the kidneys.
From the side of the cardiovascular system: with prolonged use of large doses - a decrease in capillary permeability (possible deterioration of tissue trophism, increased blood pressure, hypercoagulation, development of microangiopathies).
allergic reactions: skin rash, skin hyperemia.
Laboratory indicators: thrombocytosis. hyperprothrombinemia, erythropenia, neutrophilic leukocytosis, hypokalemia. glycosuria.
Local reactions: soreness at the site of intramuscular injection.
Other: with prolonged use of large doses (more than 1 g) - inhibition of the functions of the insular apparatus of the pancreas (hyperglycemia, glucosuria), with intravenous administration - the threat of abortion (due to estrogenemia), hemolysis of erythrocytes.

Overdose

Symptoms: nephrolithiasis. insomnia, irritability, hypoglycemia.
Treatment: symptomatic, forced diuresis is effective.

Interaction with other drugs

Increases the concentration in the blood of benzylpenicillin and tetracyclines; at a dose of 1 g / day, it increases the bioavailability of ethinylestradiol (including that which is part of oral contraceptives).
Reduces the effectiveness of heparin and indirect anticoagulants.
With simultaneous use with acetylsalicylic acid (ASA), the excretion of ascorbic acid in the urine increases and the excretion of ASA decreases.
Increases the risk of developing crystalluria in the treatment of salicylates and short-acting sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs that have an alkaline reaction (including alkaloids), reduces the concentration of oral contraceptives in the blood.
Increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body.
Medicines of the quinoline series, calcium preparations, salicylates, glucocorticosteroid drugs with prolonged use deplete the reserves of ascorbic acid.
With simultaneous use reduces the chronotropic effect of isoprenaline.
With prolonged use or use in high doses, it may interfere with the interaction of disulfiram and ethanol.
In high doses, it increases the excretion of mexiletin by the kidneys.
Barbiturates and primidone increase the excretion of ascorbic acid in the urine.
Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives. tubular reabsorption of amphetamine and tricyclic antidepressants.
Pharmaceutically incompatible with aminophylline. bleomycin. cefapirin, chlordiazepoxide, estrogens. dextrans. doxapram, erythromycin, methicillin, nafcillin, benzylpenicillin, warfarin.

special instructions

In connection with the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor adrenal function and blood pressure.
High doses of ascorbic acid increase oxalate excretion, contributing to the formation of kidney stones. In newborns whose mothers took high doses of ascorbic acid, and in adults who took high doses, "rebound" scurvy may be observed. With prolonged use of large doses, inhibition of the function of the insular apparatus of the pancreas is possible, therefore, in the course of treatment, it is necessary to regularly monitor the level of glycemia.
In patients with high iron content in the body, ascorbic acid should be used in minimal doses.
Ascorbic acid as a reducing agent can distort the results of various laboratory tests (blood and urine levels of glucose, bilirubin, activity of "liver" transaminases and lactate dehydrogenase).

Influence on the ability to drive vehicles and mechanisms

During the period of treatment, care must be taken when driving vehicles, mechanisms and engaging in potentially hazardous activities that require concentration and speed of psychomotor reactions.

Release form

Solution for intravenous and intramuscular administration 50 mg/ml.
2 ml in colorless or colored glass ampoules. 5 or 10 ampoules in a blister pack made of a polyvinyl chloride or polyethylene terephthalate film with a polymer film or lacquered aluminum foil or without a polymer film and lacquered aluminum foil or in a cardboard form with cells for laying ampoules.
1 blister pack or cardboard form with 10 ampoules or 2 blister packs or cardboard forms with 5 ampoules together with instructions for use and ampoule scarifier or without it in a cardboard pack.

Storage conditions

At a temperature not higher than 25°C.
Keep out of the reach of children.

Best before date

1 year.
Do not use after the expiration date!

Holiday conditions

Released by prescription.

Manufacturer

Manufacturer/Organization receiving claims

LLC "Groteks"

Registration certificate holder
LLC "Groteks"
Russia. 195279, St. Petersburg, Industrialny pr., 71, building 2, lit. A

APPROVED

Order of the Chairman of the Committee

Control of medical and

Pharmaceutical activities

Ministry of Health

Republic of Kazakhstan

From "_____"_______2011

№ ______________

Instructions for medical use

medicinal product

Ascorbic acid

Tradename

Ascorbic acid

International non-proprietary name

Ascorbic acid

Dosage form

Solution for injection 5%

Compound

active substance- ascorbic acid - 50.0 g,

Excipients: sodium bicarbonate - up to pH 5.7-7.0, anhydrous sodium sulfite - 2.0 g, water for injection saturated with carbon dioxide - up to 1.0 l.

Description

Clear colorless or slightly colored liquid.

Pharmacotherapeutic group

Vitamins. Ascorbic acid.

Code ATCA11GA01

Pharmacological properties

Pharmacokinetics. After intramuscular administration, it is easily and quickly absorbed. It is transported in leukocytes and platelets, where its concentration is 10-30 times higher than the concentration in plasma. The highest concentrations are created in the posterior pituitary gland, adrenal cortex, retinal epithelium, gonads, liver, brain, pancreas, lungs, kidneys and muscle tissue.

It is metabolized mainly in the liver, into deoxyascorbic and then into oxaloacetic and diketogulonic acids. It is excreted in urine, feces and then in the form of inactive products.

Pharmacodynamics.
Vitamin agent, has a metabolic effect. Regulates redox processes, carbohydrate metabolism, blood clotting, tissue regeneration; increases the body's resistance to infections, reduces vascular permeability. It has pronounced antioxidant properties. Improves the use of glucose in the tricarboxylic acid cycle, participates in the formation of tetrahydrofolic acid, the synthesis of steroid hormones, collagen, procollagen.

Maintains normal capillary permeability (inhibits hyaluronidase).

Activates proteolytic enzymes, participates in the exchange of aromatic amino acids, pigments and cholesterol, promotes the accumulation of glycogen in the liver. Due to the activation of respiratory enzymes in the liver, it enhances its detoxification and protein-forming functions, increases the synthesis of prothrombin.

Improves bile secretion, restores the exocrine function of the pancreas and the endocrine function of the thyroid gland.

Regulates immunological reactions: synthesis of antibodies, γ-interferon, C3-component of the compliment system, phagocytosis and increases the body's resistance to infectious diseases.

It has a weak anti-inflammatory and anti-allergic effect by reducing the release and accelerating the degradation of histamine and prostaglandins.

Indications for use

Hypovitaminosis and avitaminosis C (scurvy);

Hemorrhagic diathesis, capillarotoxicosis, hemorrhagic stroke;

Bleeding (nasal, after extraction of teeth, uterine, pulmonary);

Acute radiation sickness;

Correction of systemic alkalosis;

The period of convalescence after infectious diseases and intoxications;

Post-transfusion complications;

Liver diseases (chronic hepatitis and cirrhosis) as part of complex therapy;

Chronic adrenal insufficiency (Addison's disease), adrenal crisis in Addison's disease;

Hypoacid gastritis, enteritis, colitis;

Sluggish wounds and ulcers, bone fractures;

Intense physical and mental stress;

Antidote therapy for poisoning with aconite, aniline, benzene, dichloroethane, potassium permanganate, methyl alcohol, arsenic, thallium, phenol, benzocaine, quinine, teturam.

Dosage and administration

Apply intramuscularly and intravenously. Adults: 50-250 mg (1-5 ml of 5% solution) 1-2 times a day. When carrying out antidote therapy, up to 3000 mg (60 ml / day of a 5% solution) is administered intravenously by drip slowly diluted with 50-100 ml of a 0.9% sodium chloride solution.

In the treatment of adrenal crisis, 250-500 mg (5-10 ml of a 5% solution) are administered intravenously slowly every 3-4 hours.

Children under the age of 6 months are prescribed 20-30 mg / day (0.4-0.6 ml of a 5% solution),
at the age of 6-12 months - 35 mg / day (0.7 ml of a 5% solution),
1-3 years - 40 mg / day (0.8 ml of a 5% solution),
4-10 years - 45 mg / day (0.9 ml of a 5% solution),
11-14 years old - 50 mg / day (1 ml of a 5% solution),
for children over 15 years old 60-100 mg (1.2-2 ml of 5% solution) 1 time per day.

Side effects

Increased blood pressure;

Inhibition of the endocrine function of the pancreas (hyperglycemia, glucosuria);

Thrombocytosis, anemia, neutrophilia;

Hyperprothrombinemia, thrombophilia;

Allergic reactions (including anaphylactic shock);

Impaired kidney function (glomerulopathy);

Violation of the metabolism of zinc and copper with prolonged use, leading to a neurotoxic effect (increased excitability, sleep disturbance);

Myocardial dystrophy;

Urolithiasis (formation of oxalate stones).

Contraindications

Hypersensitivity;

Hypercoagulation, thrombophlebitis and thromboembolic conditions at present or in history;

Non-insulin dependent diabetes mellitus.

Drug Interactions

Increases the concentration of salicylates in the blood and increases the risk of developing oxaluria.

Increases the absorption of ethinylestradiol, tetracycline and penicillins.

Promotes the absorption of iron and its deposition in a reduced form.

Ascorbic acid and combined oral contraceptives mutually reduce the concentration of each other.

Barbiturates and primidone increase the excretion of ascorbic acid in the urine.

In high doses, ascorbic acid increases the excretion of amphetamine and tricyclic antidepressants.

When used simultaneously with deferoxamine, it potentiates its effect and increases iron excretion.

Weakens the effects of indirect anticoagulants (phenindione, warfarin, neodicoumarin) and heparin.

With prolonged use of quinolones, calcium chloride, salicylates and glucocorticosteroids reduce the level of ascorbic acid in plasma and its content in the body.

Smoking and ethyl alcohol accelerate the metabolism of ascorbic acid and reduce its content in the body.

Food products containing cucumbers, zucchini and parsley weaken the therapeutic effect of ascorbic acid.

special instructions

Pregnancy and lactation. Ascorbic acid crosses the placenta and is excreted in breast milk. The use of ascorbic acid in high doses during pregnancy and lactation can lead to the development of ascorbic disease (scurvy-like condition) in newborns as a withdrawal reaction. It is not recommended to exceed the requirements for ascorbic acid during pregnancy (60-70 mg / day) and lactation (80-90 mg / day).

Use with caution. Care must be taken when prescribing ascorbic acid to patients with hyperoxaluria and oxalate calculi in the kidneys, in patients with hemochromatosis, thalassemia, polycythemia, sideroblastic anemia and lymphoproliferative diseases.

Use in high doses. The use of ascorbic acid in doses above 500 mg / day can provoke a hemolytic crisis in people with glucose-6-phosphate dehydrogenase deficiency, sickle cell anemia, and lead to the development of acute left ventricular failure.

Use in oncology. The use of ascorbic acid in high doses in patients with rapidly proliferating and widely disseminated tumors can aggravate the course of the process. Therefore, ascorbic acid should be used with caution in this group of patients.

Influence on the ability to drive vehicles and control mechanisms. Does not affect.

Impact on laboratory parameters. When treating with ascorbic acid, the results of determining the level of blood glucose, bilirubin, transaminase activity and LDH may be distorted.

Overdose

Overdose symptoms occur when ascorbic acid is administered in large doses or over a long period of time. Characterized by the development of arterial hypertension, hyperglycemia, glucosuria, metabolic acidosis, thromboembolic complications.

Assistance measures include drug withdrawal, symptomatic therapy (blood pressure control, administration of antiplatelet agents, insulin, alkalizing agents). There is no specific antidote. Hemodialysis and peritoneal dialysis are ineffective.

Release form and packaging

1.2 ml in glass ampoules.

A paper label or a self-adhesive label is glued onto each ampoule, or the text is applied to the ampoule by intaglio printing with quick-fixing ink.

Ascorbic acid is an organic compound related to a substance such as glucose. Ascorbic acid is one of the main acid elements in the human body. The functional abilities of ascorbic acid are aimed at restorative processes and the establishment of metabolic processes.

The main active element in the composition of ascorbic acid is vitamin C, which is an essential vitamin to support the body and immunity at a good level. Therefore, this acid is often referred to simply as vitamin C. Ascorbic acid is often found in nature, it is found in many fruits and some vegetables.

Ascorbic acid in its properties is a white or light yellow powder, which has a sour taste. In addition, this type of acid dissolves very well in liquids, giving a sour taste to the water in which it will be dissolved.

In 1932, when vitamin C was first discovered, huge plans were placed on its share. But experiments have shown that with the help of ascorbic acid, one can only support the human body and prevent many already clinical cases of various diseases.

Who needs to take ascorbic acid and when?

The main cases of the use of ascorbic acid:

• Usually, ascorbic acid is needed by people who have been poisoned by carbon monoxide or other harmful gaseous substances. In case of serious poisoning, ascorbic acid normalizes the processes associated with oxidation and restores the normal environment in the human body. In cases of poisoning, the dose of ascorbic acid can be up to 0.25 ml per 1 kg of body weight.

• The lack of vitamins during the change of seasons is also a reason for the use of ascorbic acid. It can be both a drug and vitamin C-containing fruits and vegetables that need to be added to the daily menu. This will help strengthen the immune system and make it easier to endure such a period.
• Pregnancy. During pregnancy, many girls experience a lack of vitamin C. As prescribed by a doctor, the use of ascorbic acid is recommended. On average, a pregnant woman should receive 30% more ascorbic acid than before pregnancy.
• Smoking. As with carbon monoxide poisoning, smokers need an increased dose of vitamin C. This is necessary to restore the acidic environment in the body.

The benefits of ascorbic acid

The benefits of ascorbic acid can be judged by the symptoms of its lack. The lack of proper amount of vitamin C can be noticed with the following symptoms:

• Paleness of the skin;
• Weakened immunity;
• Increased wound healing time;
• Bleeding gums, loose teeth;
• General malaise;
• restlessness and poor sleep;
• Pain in the lower extremities (especially the heels and feet)

Ascorbic acid acts to prevent these symptoms from appearing. It will also be useful if available.

The harm of ascorbic acid

A quality preparation of ascorbic acid in itself is safe. But this does not mean that you can eat ascorbic acid in batches. A number of contraindications to this drug are still available. The basis of the problem is an overdose of vitamin C, in which there is nothing to worry about either, but this is only for healthy people, but for those who have stomach problems (gastritis, ulcers), the use of such an amount of acid can cause a number of complications.

Overdose of ascorbic acid

An excess of acid badly affects the condition of the stomach and digestive tract, corroding the walls of the stomach. This is a real problem for people with digestive disorders.

If an overdose did happen, then it will be useful to know some of its consequences now.

For example, in pregnant women, metabolism can be disturbed or out of control, which can lead the mother and fetus to certain problems. The unborn child may become more susceptible to allergies, and the mother may develop stomach problems.

Side effects of use ascorbic acid

Vitamin C, like all ascorbic acid, is water-soluble, which means that if you take more of it than the body needs, then the excess will simply be excreted. But it can cause indigestion, stomach pain, diarrhea, or cramps if taken in too much. If you plan to take additional vitamin C, you should increase the dose gradually over time to evaluate possible side effects.

What drugs are not compatible with taking ascorbic acid?

Ascorbic acid should not be used in combination with drugs that contain a large amount of iron, caffeine, vitamin B12, folic acid. More complete and detailed information about compatibility is better to read in the annotation, it is in each package.

What should you know before using ascorbic acid?

The use of ascorbic acid depends on specific factors. Firstly, you need a medical consultation, and secondly, you need to buy ascorbic acid in tablets or liquids in pharmacies of a large network, this is very important because counterfeit drugs are increasingly coming across on the shelves.

It is better to use this drug after a meal. Doses for preventive treatment of beriberi 50-100 mg per adult per day. For children, the norm is 25-75 mg. Of course, this dose depends on the person's body weight and age. Larger doses are used for diseases during intensive treatment with the drug.

When using ascorbic acid, it should be correct, it is necessary to observe the correct dosage, avoid incompatible drugs and consult a doctor. Unfortunately, many people think that vitamins are not superfluous, but in fact, an excess of vitamins often puts the body under stress and makes it vulnerable to disease. Often, an excess of vitamins is more harmful than their lack, although it is less common.

The fact that smoking increases the need for vitamin C - I will keep in mind. Because I smoke. Thanks for the info!

The main thing here is to monitor the children so that they do not eat a lot of these vitamins. I remember, as a child, I myself loved these sour vitamins and could eat them in batches, if not for my mother.

Ascorbic acid, of course, is produced in any form and in different doses, this must also be taken into account when giving it to children.

There are a lot of controversial statements in this article. For example, pregnant women, as a rule, are not prescribed ascorbic acid, because it can cause bleeding. A woman receives the necessary amount of vitamin C from fruits and vegetables, which should prevail in her diet.

Where does this information come from that ascorbic acid can cause bleeding during pregnancy? In the right doses, it shouldn't do any harm. Maybe you confused it with acetylsalicylic acid (aspirin), which is more likely to cause such a problem?

Good day!

Oh, tell me, please, just an hour ago I ate 8 pieces (100 mg in 1 tab. written) of ascorbic acid, I didn’t even think that they could be harmful when we take it. I have 10 obstetric weeks (9.5 to be exact) now I sit and worry. Maybe drink more water or something to eat. I won’t eat them better anymore, but I don’t know today I went to the pharmacy and bought and ate them automatically

You shouldn't worry. Although the recommended daily dose of vitamin C (ascorbic acid) for women is 75 mg, 2000 mg is considered to be the upper acceptable limit. This is at least 20 tablets containing 100 mg of ascorbic acid (if you do not take into account the eaten foods containing vitamin C). And many tablets even contain only 25-50 mg. After this acceptable limit, side effects (nausea, diarrhea) may occur. And so everything superfluous will simply be excreted with urine.

But with extreme caution during pregnancy, ascorbic acid should be taken if there is a risk of high blood pressure, and some rare genetic diseases.

So don't worry. But in the future, do not take more than the norm. Better yet, choose natural sources of this vitamin - a large orange, a glass of strawberries, red peppers ...

Health to you and your future baby

After a hard workout, severe oxygen starvation happened, the lungs became numb and the blood seemed to stop carrying oxygen. He suffered greatly to the point of fainting, and somehow in the cupboard lay pills of ascorbic acid. I read somewhere that AK restores the body, in short, I put two dragees in my mouth and, lo and behold, after 15 minutes I could breathe easily again, my lungs again earned oxygen, it opened, as if removed by hand.

Hello, in the morning, after a light breakfast, I went to the hospital and they injected me with ferrum lek (because of anemia) and intravenous ascorbic acid, after which nausea, vomiting, and dizziness immediately became worse. It was the third day. It happens? 21 weeks pregnant

I'm sorry, in fact the situation is acute and required an urgent response. But now he got sick and almost did not visit the PC for a week. Here are the words of a doctor (a good therapist, site consultant):

Ascorbic acid with glucose (Ascorbic acid with glucose)

Active substance

Pharmacological group

Nosological classification (ICD-10)

Composition and form of release

1 vial with lyophilized powder for the preparation of an injection solution contains ascorbic acid 0.05 g, complete with water for injection, in 2 ml ampoules; in a package of 5 sets.

pharmachologic effect

Participates in the regulation of carbohydrate metabolism, redox processes, blood clotting, capillary permeability, tissue regeneration, synthesis of steroid hormones, collagen, procollagen.

Indications of the drug Ascorbic acid with glucose

Avitaminosis and hypovitaminosis C; hemorrhagic diathesis, bleeding (nasal, pulmonary, hepatic, uterine, caused by radiation sickness); overdose of anticoagulants; infectious diseases and intoxications; Addison's disease, nephropathy of pregnant women; sluggishly healing wounds and bone fractures; dystrophy; mental and physical stress.

Side effects

Inhibition of the function of the insular apparatus of the pancreas (with prolonged use).

Dosage and administration

In / m, in / in, before administration, the lyophilized powder is dissolved in 1-2 ml of sterile water for injection, for adults - 1-3 ml of a 5% solution (2-6 ml of a 2.5% solution) per day; children - 1-2 ml of a 5% solution (2-4 ml of a 2.5% solution) per day.

Precautionary measures

Be wary appoint with increased blood clotting, thrombophlebitis, a tendency to thrombosis, diabetes. It is necessary to monitor renal function and blood pressure, especially when prescribing large doses.

Storage conditions of the drug Ascorbic acid with glucose

Keep out of the reach of children.

Shelf life of the drug Ascorbic acid with glucose

lyophilisate for the preparation of a solution for intravenous and intramuscular injection 0.05 g - 2 years.

tablets 100 mg + 877 mg 100 mg + 877 - 1 year.

dragee 50 mg - 1.5 years.

Do not use after the expiry date stated on the packaging.

Prices in pharmacies in Moscow

The information provided on the prices of drugs is not an offer to sell or buy goods.

The information is intended solely for comparing prices in stationary pharmacies operating in accordance with Article 55 of the Federal Law "On the Circulation of Medicines" dated April 12, 2010 N 61-FZ.

tablets 100 mg + 877 mg 100 mg + 877, 10 pcs.

tablets 100 mg + 877 mg 100 mg + 877, 40 pcs.