Biseptol in ampoules. Biseptol, solution for infusion (ampoules). Terms of dispensing from pharmacies


Antibacterial sulfanilamide drug

Active ingredients

Sulfamethoxazole (sulfamethoxazole)
- trimethoprim (trimethoprim)

Release form, composition and packaging

Pills white with a yellowish tint, round, flat, beveled and engraved "Bs".

Excipients: potato starch - 44.25 mg, talc - 3.75 mg, magnesium stearate - 1.25 mg, polyvinyl alcohol - 0.75 mg.

Pills white with a yellowish tint, round, flat, with a notch and engraved "Bs".

Excipients: potato starch - 177 mg, talc - 15 mg, magnesium stearate - 5 mg, polyvinyl alcohol - 3 mg.

14 pcs. - blisters (2) - packs of cardboard.
20 pcs. - blisters (1) - packs of cardboard.

pharmachologic effect

Combined antibacterial drug, contains sulfamethoxazole and trimethoprim.

Sulfamethoxazole, similar in structure to PABA, disrupts the synthesis of dihydrofolic acid in bacterial cells, preventing the inclusion of PABA in its molecule.

Trimethoprim enhances the action of sulfamethoxazole, disrupting the reduction of dihydrofolic acid to tetrahydrofolic acid, the active form responsible for protein metabolism and microbial cell division.

It is a bactericidal drug with a wide spectrum of action.

Active towards the following microorganisms: Streptococcus spp. (hemolytic strains are more sensitive to penicillin), Staphylococcus spp., Streptococcus pneumoniae, Neisseria meningitidis, Neisseria gonorrhoeae, Escherichia coli (including enterotoxogenic strains), Salmonella spp. (including Salmonella typhi and Salmonella paratyphi), Vibrio cholerae, Bacillus anthracis, Haemophilus influenzae (including ampicillin-resistant strains), Listeria spp., Nocardia asteroides, Bordetella pertussis, Enterococcus faecalis, Klebsiella spp., Proteus spp., Pasteurella spp., Francisella tularensis , Brucella spp., Mycobacterium spp. (including Mycobacterium leprae), Citrobacter spp., Enterobacter spp., Legionella pneumopbila, Providencia, some species of Pseudomonas (except Pseudomonas aeruginosa), Serratia marcescens, Shigella spp., Yersinia spp., Morganella spp., Pneumocystis carinii, Chlamydia spp. (including Chlamydia trachomatis, Chlamydia psittaci); protozoa - Plasmodium spp., Toxoplasma gondii; Actinomyces israeli; pathogenic fungi - Coccidioides immitis, Histoplasma capsulatum; Leishmania spp.

Resistant to the drug: Corynebacterium spp., Pseudomonas aeruginosa, Mycobacterium tuberculosis, Treponema spp., Leptospira spp., viruses.

It inhibits the vital activity of Escherichia coli, which leads to a decrease in the synthesis of thiamine, riboflavin, and other B vitamins in the intestine.

The duration of the therapeutic action is 7 hours.

Pharmacokinetics

Suction

After taking the drug inside, the active substances are completely absorbed from the gastrointestinal tract. Cmax in the blood is achieved within 1-4 hours after ingestion.

Distribution

Trimethoprim penetrates well into tissues and biological media of the body: lungs, kidneys, prostate, bile, saliva, sputum, cerebrospinal fluid. The binding of trimethoprim to plasma proteins is 50%; sulfamethoxazole - 66%.

breeding

T 1/2 trimethoprim - 8.6-17 hours, sulfamethoxazole - 9-11 hours. The main route of excretion is the kidneys; while trimethoprim is excreted unchanged up to 50%; sulfamethoxazole - 15-30% in active form.

Indications

Treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug:

- respiratory tract infections (including bronchitis, pneumonia, lung abscess, pleural empyema);

- otitis, sinusitis;

- infections of the genitourinary system (including pyelonephritis, urethritis, salpingitis, prostatitis);

- gonorrhea;

- infections of the gastrointestinal tract (including typhoid fever, paratyphoid fever, bacillary dysentery, cholera, diarrhea);

- infections of the skin and soft tissues (including furunculosis, pyoderma).

Contraindications

- established diagnosis of damage to the liver parenchyma;

- severe renal dysfunction in the absence of the ability to control the concentration of the drug in the blood plasma;

- severe renal failure (CC less than 15 ml / min);

- severe blood diseases (aplastic anemia, B 12 deficiency anemia, agranulocytosis, leukopenia, megaloblastic anemia, anemia, hyperbilirubinemia in children associated with folic acid deficiency);

- deficiency of glucose-6-phosphate dehydrogenase (risk of hemolysis);

- simultaneous use with dofetelide, paclitaxel and;

- simultaneous use with clozapine due to the ability of the latter to cause agranulocytosis;

- pregnancy;

- lactation;

- children's age up to 3 years (for this dosage form);

- hypersensitivity to the components of the drug;

- hypersensitivity to, trimethoprim, sulfonamides.

Carefully the drug is prescribed for folic acid deficiency in the body, bronchial asthma, thyroid diseases.

Dosage

The drug is taken orally after meals with a sufficient amount of liquid. The dose is set individually.

Children aged 3 to 5 years the drug is prescribed 240 mg (2 tab. 120 mg) 2 times / day; children aged 6 to 12 years- 480 mg (4 tablets of 120 mg or 1 tablet of 480 mg) 2 times / day.

At pneumonia the drug is prescribed at the rate of 100 mg of sulfamethoxazole per 1 kg of body weight / day. The interval between doses is 6 hours, the duration of admission is 14 days.

At gonorrhea the dose of the drug is 2 g (in terms of sulfamethoxazole) 2 times / day with an interval between doses of 12 hours.

Adults and children over 12 years old the drug is prescribed 960 mg 2 times / day, with long-term therapy - 480 mg 2 times / day.

The duration of the course of treatment is from 5 to 14 days. At severe disease and / or chronic infections it is possible to increase the single dose by 30-50%.

With the duration of the course of therapy for more than 5 days and / or an increase in the dose of the drug, it is necessary to control the picture of peripheral blood; when pathological changes appear, folic acid should be prescribed at a dose of 5-10 mg / day.

At patients with renal insufficiency with CC 15-30 ml / min the standard dose of the drug should be reduced by 50%, with CC less than 15 ml / min it is not recommended to use the drug.

Side effects

The drug is usually well tolerated.

From the nervous system: headache, dizziness; in some cases - aseptic meningitis, depression, apathy, tremor, peripheral neuritis.

From the respiratory system: bronchospasm, dyspnea, cough, pulmonary infiltrates.

From the digestive system: nausea, vomiting, loss of appetite, diarrhea, gastritis, abdominal pain, glossitis, stomatitis, cholestasis, increased activity of hepatic transaminases, hepatitis, sometimes with cholestatic jaundice, hepatonecrosis, pseudomembranous enterocolitis, pancreatitis.

From the hematopoietic system: leukopenia, neutropenia, thrombocytopenia, agranulocytosis, megaloblastic anemia, aplastic and hemolytic anemia, eosinophilia, hypoprothrombinemia, methemoglobinemia.

From the urinary system: polyuria, interstitial nephritis, impaired renal function, crystalluria, hematuria, increased urea concentration, hypercreatininemia, toxic nephropathy with oliguria and anuria.

From the musculoskeletal system: arthralgia, myalgia.

Allergic reactions: itching, photosensitivity, urticaria, drug fever, rash, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), exfoliative dermatitis, allergic myocarditis, fever, angioedema, scleral hyperemia.

From the side of metabolism: hypoglycemia, hyperkalemia, hyponatremia.

Overdose

Symptoms: with an overdose of sulfonamide - lack of appetite, intestinal colic, nausea, vomiting, dizziness, headache, drowsiness, loss of consciousness, fever, hematuria, crystalluria are also possible. Later, bone marrow depression and jaundice may develop.

After acute poisoning with trimethoprim, nausea, vomiting, dizziness, headache, depression, confusion, depression of bone marrow function are possible.

It is not known what dose of co-trimoxazole can be life-threatening.

Chronic poisoning: The use of co-trimoxazole in high doses over an extended period can lead to depression of bone marrow function, manifested by thrombocytopenia, leukopenia or megaloblastic anemia.

Treatment: discontinuation of the drug and taking measures aimed at its removal from the gastrointestinal tract (carry out a gastric lavage no later than 2 hours after taking the drug or induce vomiting), drink plenty of water if diuresis is insufficient and kidney function is preserved. Enter calcium folinate (5-10 mg / day). The acidic environment of urine accelerates the excretion of trimethoprim, but may also increase the risk of crystallization of the sulfonamide in the kidneys.

The blood picture, the composition of electrolytes in plasma and other biochemical parameters should be monitored. Hemodialysis is moderately effective, and peritoneal dialysis is ineffective.

drug interaction

With the simultaneous use of the drug with thiazide diuretics, there is a risk of thrombocytopenia and bleeding (the combination is not recommended).

Co-trimoxazole increases the indirect anticoagulant activity, as well as the effect of hypoglycemic drugs and methotrexate.

Co-trimoxazole reduces the intensity of hepatic metabolism of phenytoin (increases its T 1/2 by 39%) and warfarin, enhancing their action.

Rifampicin reduces T 1/2 trimethoprim.

With the simultaneous use of pyrimethamine in doses exceeding 25 mg / week, the risk of developing megaloblastic anemia increases.

With the simultaneous use of diuretics (usually thiazide) increases the risk of thrombocytopenia.

Benzocaine, procaine, procainamide (as well as other drugs, as a result of which PABA is formed as a result of hydrolysis) reduce the effectiveness of Biseptol.

Between diuretics (including thiazides, furosemide) and oral hypoglycemic agents (sulfonylurea derivatives), on the one hand, and antibacterial agents of the sulfonamide group, on the other hand, a cross-allergic reaction may develop.

Phenytoin, barbiturates, PAS increase the manifestations of folic acid deficiency when used simultaneously with Biseptol.

Derivatives enhance the action of Biseptol.

Ascorbic acid, hexamethylenetetramine (as well as other drugs that acidify urine) increase the risk of developing crystalluria during the use of Biseptol.

Kolestiramin reduces absorption when taken with other drugs, so it should be taken 1 hour after or 4-6 hours before taking co-trimoxazole.

With simultaneous use with drugs that inhibit bone marrow hematopoiesis, the risk of myelosuppression increases.

Biseptol may increase plasma concentrations of digoxin in some elderly patients.

Biseptol may reduce the effectiveness of tricyclic antidepressants.

Patients after kidney transplantation with the simultaneous use of co-trimoxazole and cyclosporine have a transient dysfunction of the transplanted kidney, manifested by an increase in serum creatinine concentrations, which is probably caused by the action of trimethoprim.

Biseptol reduces the effectiveness of oral contraception (inhibits the intestinal microflora and reduces the enterohepatic circulation of hormonal agents).

special instructions

The drug should be prescribed only in cases where the advantage of such combination therapy over other antibacterial monopreparations outweighs the possible risk. Since the sensitivity of bacteria to in vitro antibacterial drugs varies in different geographic areas and over time, local characteristics of bacterial susceptibility should be taken into account when choosing a drug.

Hypersensitivity and allergic reactions

At the first appearance of a skin rash or any other severe adverse reaction, the drug should be discontinued. Biseptol should be administered with caution to patients with a tendency to allergic reactions and bronchial asthma.

Infiltrates in the lungs (like eosinophilic or allergic alveolitis) may present with symptoms such as cough or shortness of breath. With the appearance or sudden increase in these symptoms, it is necessary to re-examine the patient and consider stopping treatment with Biseptol.

Kidney disorders

Sulfonamides, including Biseptol, may increase diuresis, especially in patients with edema caused by heart failure. Careful monitoring of kidney function and serum potassium concentration is necessary for patients receiving high doses of Biseptol (including in the treatment of pneumocystis pneumonia caused by Pneumocystis jirovecii), as well as the following groups of patients: patients with a history of impaired potassium metabolism, receiving standard drug doses; patients with renal insufficiency; patients receiving drugs that contribute to the development of hyperkalemia.

Serious adverse reactions

Fatalities have been reported, although rare, associated with adverse reactions such as pathological blood changes, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), drug rash with eosinophilia and systemic manifestations (DRESS syndrome), and fulminant hepatic necrosis .

Special patient groups

In elderly and senile patients, as well as in patients with concomitant diseases, for example, impaired renal and / or liver function, or while taking other drugs, there is an increased risk of severe adverse reactions; in these cases, the risk of development is related to the dose and duration of therapy.

The duration of treatment with Biseptol should be as short as possible, especially in elderly and senile patients. In case of impaired renal function, the dose should be adjusted according to the instructions in the "Dosage regimen" section. Patients with severe renal impairment (CC 15-30 ml / min) receiving trimethoprim-sulfamethoxazole should be carefully monitored for the development of symptoms of toxicity (nausea, vomiting, hyperkalemia).

Biseptol can be prescribed to patients with severe hematological diseases only as an exception.

In elderly and senile patients, as well as in patients with pre-existing folic acid deficiency or renal insufficiency, hematological changes characteristic of folic acid deficiency may occur. These changes disappear after the appointment of folic acid.

Due to the possibility of hemolysis, Biseptol should not be prescribed to patients with glucose-6-phosphate dehydrogenase deficiency, except in the presence of absolute indications and only in minimal doses.

As with any sulfonamide, caution should be exercised in patients with porphyria or thyroid dysfunction. Patients whose metabolism is characterized by "slow acetylation" are more likely to develop idiosyncrasy to sulfonamides.

Long-term therapy

With prolonged use of the drug Biseptol, it is necessary to regularly determine the number of blood cells. With a significant decrease in the number of any blood cells, Biseptol should be discontinued.

Patients receiving long-term treatment with Biseptol (especially with renal insufficiency) should regularly do a general urinalysis and monitor kidney function. During treatment, adequate fluid intake and adequate diuresis should be ensured to prevent crystalluria.

Impact on laboratory results

Trimethoprim may change the results of enzymatic assays for serum methotrexate, but does not affect the results of radioimmunoassay.

Co-trimoxazole can increase by 10% the results of the Jaffe reaction with picric acid for the quantitative determination of creatinine.

Influence on the ability to drive vehicles and control mechanisms

The drug, as a rule, does not affect the psychophysical abilities and the ability to service mechanisms and drive a vehicle. However, if undesirable symptoms such as headache, tremor, nervousness, feeling of fatigue appear, care should be taken while driving or servicing machinery.

In elderly and senile patients, there is an increased risk of severe adverse reactions associated with the dose and duration of therapy.

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Terms and conditions of storage

The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life - 5 years.

"Biseptol" has been known for more than a dozen years. In Soviet times, it was the most popular drug for almost any infectious disease, it is available for both adults and children, its price is not high, but the drug is effective. Gradually, it was replaced by new drugs with a large spectrum of action and efficiency. But even today, "Biseptol" does not lose its relevance, and the reviews of doctors confirm this.

Composition and principle of action

When is biseptol used and how much should I drink? One tablet of "Biseptol" 120 mg contains 100 mg of sulfamethoxazole, 20 mg of trimethoprim and additional components. Accordingly, a dose of 240 mg or 480 mg contains two and three times more active substances. The combined action of the components of the drug is aimed at inhibiting the formation of folic acid in the bacterial cell. Substances are selected in such a way that they enhance the effect of each other. This adds to the effectiveness of the drug.

Its action is as follows:

  • sulfamethoxazole- has a structure similar to para-aminobenzoic acid, due to which it interferes with the formation of folic acid;
  • trimethoprim - slows down the transition of vitamin B9 precursors to the active form.

Thanks to this, minimal concentrations of folic acid are created, which is essential for the growth and development of bacteria. "Biseptol" in high concentration causes the death of pathogens sensitive to it and, thus, eliminates the infection.

The activity of the drug extends to the following microorganisms:

  • coli;
  • streptococci;
  • staphylococci;
  • pneumococci;
  • typhoid and dysentery bacteria;
  • gonococci;
  • salmonella;
  • hemophilic bacillus;
  • klebsiella;
  • enterococcus;
  • chlamydia;
  • toxoplasma;
  • leishmania.

The agent does not act on Pseudomonas aeruginosa and tubercle bacillus, leptospira, spirochetes and viruses.

When to use

Modern doctors "Biseptol" are prescribed for pathologies caused by pathogenic microbes susceptible to the effects of sulfamethoxazole. The method of application is indicated in the table.

Organs or organ systemsPathology
upper respiratory tract- Chronic and acute bronchitis;
- inflammation of the pleura;
- pneumonia;
- abscesses;
- inflammatory complications of bronchiectasis;
- laryngitis
ENT organs- Otitis;
- sinusitis (for example, sinusitis, frontal sinusitis);
- inflammation of the tonsils (tonsillitis);
- infectious process in the mucous membrane of the larynx and pharynx
Genitourinary organs- Inflammation of the uterine appendages;
- prostatitis;
- urethritis;
- cystitis;
- epididymitis;
- chronic pyelonephritis;
- gonorrhea
Digestive system- Diarrhea of ​​bacterial etiology, including food poisoning;
- inflammation of the bile ducts
Leather- Acne;
- purulent lesions of hair follicles and soft tissues
Severe infectious and inflammatory diseases with high fever- Meningitis;
- sepsis;
- purulent lesions of the bone marrow;
- severe infections after injuries

"Biseptol" is effective in toxoplasmosis, malaria. Biseptol is prescribed for children in case of contraindications to antibiotics or an allergic reaction to commonly used agents. High efficiency of treatment is achieved with sore throat, cough with bronchitis, as well as with sinusitis, inflammation of the lungs, middle ear, intestinal infections, furunculosis, swollen lymph nodes. It should only be used as directed by a doctor.

Contraindications

After taking "Biseptol" quickly penetrates into the systemic circulation and after three to five hours reaches its maximum concentration. Metabolized in the liver. High concentrations of the drug are created in the kidneys, since it is mainly excreted in the urine. Contraindications for admission are as follows:

  • hypersensitivity to the components of the drug;
  • complex forms of heart failure;
  • liver pathology with damage or death of its cells;
  • kidney failure;
  • anemia caused by a lack of folic acid;
  • pathology of blood and bone marrow;
  • bronchial asthma;
  • hay fever;
  • atopic (allergic) dermatitis.

"Biseptol" should not be taken if the patient has had an immunological decrease in platelet levels in the past caused by taking the drug.

The components of the drug help to reduce the content of folic acid and can lead to its deficiency. In addition, the use of the drug in the third trimester of gestation may contribute to the occurrence of nuclear jaundice in the fetus. Therefore, "Biseptol" during pregnancy and during breastfeeding is categorically contraindicated for admission, and you can not use it for children under three months.

In cases of the use of "Biseptol" in pregnant women, an additional intake of 5 g of folic acid daily is necessary. Elderly people should take this drug with great caution. The same applies to patients with thyroid disorders.

Instructions for use "Biseptol"

The dosage of "Biseptol" and the duration of use is prescribed by the doctor individually in each case. You can take a convenient form, while the regimens do not differ in the amount of active substance.

"Biseptol" is available in tablets of 120 (for children) and 480 mg, in the form of syrup and suspension in ampoules for oral administration. Schemes for the use of various forms of the drug are described in the tables.

Table - How to take "Biseptol" depending on age

Tablets or suspension must be taken after a meal with clean non-carbonated water. The course of admission lasts up to 14 days. If therapy continues for more than five days, it is recommended to monitor blood counts. With abnormal fluctuations, up to 10 mg of folic acid per day is additionally prescribed.

Depending on the type and severity of the infectious process, the standard dosage of Biseptol may vary, as can be seen from the table.

Table - Separate regimens for taking "Biseptol"

In severe forms of the infectious-inflammatory process, the doctor can double the dose.

Side effects and overdose

The instructions indicate the good tolerability of the drug and the minimum risk of side effects. However, the following can be noted:

  • nausea, vomiting and diarrhea;
  • headache, dizziness;
  • tendency to depression;
  • inflammation of the peripheral nerves;
  • bronchial spasms, asthma attacks and cough;
  • obstructed outflow of bile;
  • acute inflammation of the large intestine;
  • decrease in the level of neutrophils (agranulocytosis);
  • decrease in the number of leukocytes and platelets in the blood;
  • deficiency of vitamin B12 and folic acid;
  • severe form of allergic dermatitis;
  • the appearance of blood in the urine, crystalluria.

People with HIV infection are more likely to experience side effects.

With an overdose of the drug, headache, nausea, vomiting, abdominal pain are aggravated, red blood counts change. Treatment - symptomatic, includes gastric lavage and, if necessary, the introduction of drugs to restore the level of folic acid. For example, based on calcium folinate.

special instructions

When taking Biseptol, there is a risk of the appearance of salt crystals in the urine and the formation of kidney stones, therefore, to prevent such side effects throughout the treatment, it is necessary to consume a sufficient amount of liquid and monitor the tests.

The simultaneous use of the drug with diuretics increases the risk of hypokalemia (decrease in potassium in the blood) and bleeding. For the period of treatment, it is recommended to completely abandon alcohol so as not to provoke toxic hepatitis. With prolonged therapy, it is necessary to take tests to monitor the functional state of the kidneys, liver and control hematological parameters.

Analogues

Analogues for the active ingredients are the following drugs:

  • "Bactrim";
  • "Septrin";
  • "Sumetrolim";
  • "Berlocid";
  • "Ceplin";
  • "Co-trimoxazole".

Latin name: Biseptol
ATX code: J01EE01
Active substance:
Manufacturer: Polfa, Poland
Pharmacy leave condition: On prescription
Price: from 90 to 500 rubles.

Compound

Co-trimoxazole consists of five parts of sulfamethoxazole and one part of trimethoprim. One tablet or ampoule contains (mg):

  • Sulfamethoxazole
  • Trimethoprim.

The concentrate contains the following additional components: sodium hydroxide and metabisulphite, benzyl alcohol, propylene glycol, ethanol.

Medicinal properties

"Biseptol" (480, 120 and 240 mg) is a broad-spectrum antimicrobial drug that belongs to sulfanilamide drugs. The combination of active substances prevents the synthesis of folic acid, which is responsible for metabolic processes in microbial cells, as well as their division. Co-trimoxazole does not kill pathogens of various diseases, but limits their reproduction, giving the immune system the opportunity to independently cope with pathogens. This explains the absence of a strong toxic effect during treatment with biseptol.

The active substances of the drug quickly penetrate and are distributed in the body. If a dropper is placed, then the maximum concentration is reached within an hour. When using tablets, this time increases. The main part of the drug is excreted in the urine within 72 hours, a small part in the feces.

The drug is able to cope with about 40 types of pathogenic microorganisms, including streptococcal and staphylococcal infections, vibrio cholerae, toxoplasma, salmonella, chlamydia, E. coli and others. The drug has no effect on anaerobic and mycobacteria, as well as viruses.

"Biseptol" is used for primary and secondary prevention of pneumocystosis and toxoplasmosis in HIV carriers.

Indications for use

The effect of the drug on a variety of pathogenic microflora allows it to be used for various infectious lesions:

  • Respiratory tract - bronchitis at any stage, croupous, pneumocystis and bronchopneumonia, bronchoecpathic disease
  • Genitourinary system - cystitis, pyelitis, urethritis, pyelonephritis, prostatitis, lymphogranuloma venereum and inguinal granuloma, chancre, gonorrhea
  • Gastrointestinal tract - paratyphoid and typhoid fever, cholera, salmonellosis, dysentery, gastroenteritis, cholecystitis, cholangitis
  • ENT organs - scarlet fever, sinusitis, tonsillitis, otitis media, laryngitis
  • Skin and tissues - the drug treats boils, acne, pyoderma, infections that develop in wounds
  • Other diseases - osteoarticular infections, brucellosis, sepsis, whooping cough, malaria, toxoplasmosis, South American blastomycosis.

In patients suffering from HIV infection, primary prevention of pneumocystosis is carried out if the number of CD4 + cells is less than 200 / 1 μl of blood or if patients have Candida infection of the oral mucosa. All HIV-infected patients who have already suffered pneumocystosis are indicated for secondary prevention. Events are canceled if within 3 months the number of CD4+ cells exceeds the value of 200/1 µl. "Biseptol" (480, 240, 120 mg) is used if the prevention of toxoplasmosis in HIV infection is needed.

The medicine can be purchased in tablets and concentrate, from which a solution for intravenous infusions (droppers) is prepared.

The average price is from 30 to 110 rubles.

Tablets "Biseptol"

The blister with tablets is placed in a cardboard box. The number of tablets in a package is 20 or 28 pcs. Color - white, let's say a yellowish tint. Tablet sizes - diameter 13 mm, thickness 4 mm. On one of the parties there is an imprint "Bs" and risk.

Mode of application

Biseptol tablets and concentrate are used to treat various diseases, as well as to carry out preventive measures in HIV-infected people. The therapeutic scheme is determined by the age of the patient, diagnosed and concomitant diseases, taking other medications. It is obligatory to take the medicine for 4-5 days. Additionally, therapy continues for another 2 days after the disappearance of the manifestations of the disease. Some diseases require long-term use of the drug. For example, typhoid fever is treated within 1-3 months, and acute brucellosis 3-4 weeks. A single dose of the drug can be increased up to 50% if the disease is severe or has become chronic.

Assigned after meals, washed down with water. The following standard regimen is recommended:

  • Age from 12 years - twice a day, 2 tablets (960 mg) every 12 hours. If the treatment lasts a long time, then 2 times a day, 1 tablet of the drug is taken.
  • Ages 6 to 12 years - 1 tablet twice a day
  • Pneumonia is treated with a daily dosage of 100 mg sulfamethoxazole per kilogram of body weight. The medicine is taken for 2 weeks daily at intervals of 6 hours
  • In the treatment of gonorrhea infection, 2 g of sulfamethoxazole is taken per 1 kg of weight. The drug is prescribed twice a day after 12 hours.

For children under 6 years of age, it is advisable to use tablets with a concentration of active substances of 120 mg.

Prevention of pneumocystis pneumonia is carried out according to the following scheme:

  • Age from 12 years - the daily dose is 960 mg
  • Age from 6 to 12 years - the dosage is calculated based on the body surface area: 450 mg / m2. For reference: the average surface area of ​​the body of a person weighing 70 kg is approximately equal to 1.8 m2.

For HIV patients, the prevention of pneumocystosis and toxoplasmosis consists in taking 2 tablets daily, even if side effects of moderate severity appear.

The average price is from 40 to 500 rubles.

"Biseptol" in ampoules

Concentrate - a clear liquid in dark glass ampoules has a light yellow tint or no color. There is a smell of alcohol. The carton contains 10 ampoules of 5 ml each.

Mode of application

The dropper solution is prepared immediately before the procedure and used within 6 hours. The time of administration does not exceed one and a half hours, since during this time the maximum effective concentration of the drug in the blood is achieved. The solution is administered slowly, intravenously, drip. If a precipitate or turbidity appears in the prepared liquid, then the dropper cannot be placed.

As diluents are used:

  • Dextrose solution 5%
  • Sodium chloride solution 0.9%
  • Sodium chloride solution 0.45% and dextrose 2.5%
  • Ringer's solution.

The drug is used in the following standard dosages:

  • Age from 12 years - for one dropper, 2 ampoules (10 ml of medication) are taken and diluted with 250 ml of saline. Infusion is carried out 2 times every day
  • Age up to 12 years - the therapeutic dose per 1 kg of body weight is 30 mg of sulfamethoxazole + 6 mg of trimethoprim per day. The resulting volume is used for 2 injections
  • Severe infections - droppers are placed every day 2-3 times. For one infusion, 15 ml (3 ampoules) are used.

If a large fluid intake is contraindicated for the patient, then a solution of increased concentration is prepared - 75 ml of the diluent is mixed with 5 ml of the drug.

If the kidneys do not cope with their functions, then Biseptol is prescribed taking into account creatinine clearance (CC). For CC>30 ml/min, conventional treatment is used. For CC = 15-30 ml / mi, half of the norm is prescribed. For QC<15 мл/мин препарат не используется.

The average price is from 110 to 140 rubles.

"Biseptol", suspension

The suspension is intended for oral administration. Color from white to light cream. Does not contain sugar. Has a slight strawberry scent

Mode of application

Drink the suspension after meals with plenty of water.

Adults and children over 12 years of age: 960 mg to 1440 mg (depending on the severity of the disease) every 12 hours.

The term of taking the drug for urinary tract infections is 10-14 days, for exacerbation of chronic bronchitis - 14 days, for traveler's diarrhea and shigellosis - 5 days.

For children, the dose is calculated based on the disease. The approximate dose is 36 mg / kg per day.

The course of treatment for urinary tract infections and acute otitis media - 10 days, shigellosis - 5 days. In severe infections, doses for children can be increased by 50%.

For acute infections, the minimum duration of treatment is 5 days; after the disappearance of symptoms, therapy is continued for 2 days.

After 7 days, changes are observed, if they have not occurred, the dose is adjusted or the medicine is changed.

960 mg every 12 hours drink suspension for the treatment of chancre (from 7 to 14 days).

Women with acute uncomplicated urinary tract infections are recommended to take a single dose of 1920-2880 mg, if possible in the evening after meals or at bedtime.

With pneumonia caused by Pneumocystis carinii - 30 mg per kg 4 times a day with an interval of 6 hours for 14-21 days.

For the prevention of pneumonia, adults and children over 12 years of age - 960 mg / day. For children under 12 years of age, 450 mg every 12 hours for 3 consecutive days each week.

For other bacterial infections, the dose is selected individually depending on individual indicators.

Contraindications

There are a number of conditions in which "Biseptol" of any form is not used:

  • The child is under 3 months of age
  • There is an allergy to sulfonamides, active or auxiliary components of the drug
  • Diagnosed with megaloblastic anemia, which is based on a lack of folic acid
  • There is no possibility of monitoring the composition of the patient's blood with dysfunction of the liver or kidneys.

Pregnancy and breastfeeding

Pregnant women, the drug is contraindicated. Since the drug passes into breast milk, when treating a nursing mother, the child should be transferred to artificial feeding.

Precautionary measures

With terms of treatment that differ from the standard, the concentration of sulfamethoxazole in plasma is monitored. If therapy is carried out for more than a month, then the risk of changes in blood composition increases. To normalize the indicators, folic acid is prescribed. However, with HIV infection, the use of folic acid provokes the development of resistance of the causative agent of pneumocystosis to the active substance of the drug.

With caution, "Biseptol" (480, 120 and 240) is prescribed if there are:

  • Thyroid disease or bronchial asthma
  • Folate deficiency in elderly patients
  • There is a risk of crystalluria - prevention is necessary, which consists in maintaining a normal amount of urine.

When Biseptol is used, then carrots, legumes, spinach, cauliflower, tomatoes, green parts of plants should be excluded from the diet. You should not stay under the sun for a long time.

Interaction with other drugs

"Biseptol" is able to change the effects of certain drugs:

  • Warfarin, phenytoin, and oral hypoglycemic agents increase their effect
  • The concentration of cyclosporine when used together with biseptol decreases
  • Oral contraceptives are becoming less reliable
  • The use of diuretics (especially in elderly patients) may cause thrombocytopenia.

Intravenous administration of biseptol together with drugs that contain bicarbonates is unacceptable.

Side effects

Usually patients tolerate the drug well, however, the occurrence of side effects can affect any of the systems of the human body:

  • Digestive - nausea, diarrhea, loss of appetite, vomiting, abdominal pain, inflammation of the oral mucosa and tongue, hepatitis
  • Urinary - changes in kidney function, poly-, crystal- and hematuria, an increase in the concentration of urea and creatinine
  • Respiratory - bronchospasm
  • Bone - arthralgia, myalgia
  • Nervous - headache, dizziness, sometimes there are depressive states, apathy
  • An allergic reaction manifests itself in the form of a rash, itching, an increase in body temperature, the appearance of an inadequate reaction to sunlight and UV radiation from the skin and mucous membranes.
  • Hematopoiesis - possibly a decrease in blood glucose levels, megaloblastic anemia, leuko-, neutro- and thrombocytopenia.

With HIV infection, all side effects are much more frequent and stronger.

Overdose

The maximum dose of the drug, leading to the appearance of symptoms of overdose, has not been established. A single excessive intake of the drug can cause nausea, abdominal pain, dizziness, vomiting, confusion, the appearance of crystalluria, visual impairment. Prolonged overdose is manifested by jaundice and blood changes.

If symptoms of an overdose appear, then you should rinse the stomach and provide plenty of fluids. Calcium folinate administered intramuscularly will help neutralize the negative effect on the body of trimethoprim. The daily dosage ranges from 5 to 15 mg. Perhaps hemodialysis.

Terms and conditions of storage

"Biseptol" is stored in a place protected from light. It must be out of the reach of children. The storage temperature does not exceed +25°C. The concentrate must not be frozen. The drug has been used for 5 years.

Analogues

The active substance co-trimoxazole is part of other drugs that have a similar effect on the human body.

F. Hoffmann-La Roche, Switzerland
Price from 70 to 400 rubles.

The drug is available in the form of a suspension and tablets "Bactrim forte". The content of sulfamethoxazole is 200 mg, and trimethoprim 40 mg per 5 ml of the drug. "Bactrim" has a wide range of effects on pathogenic microflora.

pros

  • Suspension can be taken by children from 3 months
  • Measuring spoon included

Minuses

  • A large number of side effects
  • The drug should not be taken during pregnancy.

« »

Biosynthesis/ Pharmstandard-Leksredstva/ Skopinsky FZ, Russia
Price from 10 to 60 rubles.

The drug is available in the form of tablets, each containing 120 or 480 mg of the active substance, as well as a suspension containing 240 mg of co-trimoxazole per 5 ml.

pros

  • Convenient form of administration in the form of a suspension and tablets with different concentrations of the active substance
  • Low price

Minuses

  • Negative effect on the hematopoietic system
  • Extensive list of side effects.

One of the most famous and controversial antibacterial drugs sold in Russia is Biseptol. In the 80-90s of the last century, Biseptol was at the peak of popularity. The drug was prescribed by doctors of all specializations, from the district pediatrician to the narrow-profile urologist. Patients, having felt the effectiveness of the remedy, perceived it as a panacea for all ills. If at first we still did not risk buying Biseptol without a doctor's prescription, then soon such a "trifle" as a specialist's recommendation began to seem redundant. In Biseptol, they saw a panacea for any infection and took it almost uncontrollably for any reason, not excluding the common cold.

Meanwhile, any antibacterial medicine is not at all so harmless. And many ardent fans of Biseptol were convinced of this, unfortunately, already from their own experience.

The modern pharmaceutical market offers a large number of safer and more effective antibacterial drugs. Sales and popularity of Biseptol faltered. However, until now, therapists and pediatricians write the long-learned words “Tab. Biseptoli” in recipes. And until now, Biseptol can be sold in our pharmacies on the recommendation not of a doctor, but of a friend, neighbor or a complete stranger who gave advice in line for bread.

In this article, we will try to highlight the positive and negative aspects of the drug and answer the main questions: is Biseptol safe? Is it worth taking this medicine uncontrollably and what is the risk?

The composition and form of release of Biseptol

Few people know that the name hides both the composition and the action of Biseptol. The particle "bi" comes from the Latin prefix "bis" - twice - and means that the composition includes two components. The second part of the name - "septol" - apparently comes from the Latin "septicus", literally meaning "rotting". In pharmaceuticals, drugs that have the root "septol" in their name belong to the group of antiseptics.

So, what are the active ingredients included in the composition? Biseptol is a combination drug consisting of two components: sulfamethoxazole at a dose of 400 mg and trimethoprim at a dose of 80 mg. The number indicated in the patented name "Biseptol 480" means nothing more than the total mass of the active ingredients of the drug.

The pharmaceutical industry produces four main forms of release:

  • Biseptol 480 mg - tablets for adults;
  • Biseptol 120 mg - tablets for children;
  • Biseptol 240 mg - suspension for children. 5 ml of the drug contains 240 mg of a combination of sulfamethoxazole and trimethoprim;
  • Biseptol 480 mg in ampoules containing a concentrate from which solutions for infusions are prepared - intravenous drip injections, or, more simply, droppers. Biseptol in ampoules is indicated for use in a hospital setting.

Some manufacturers have developed the release of Biseptol syrup for children containing 240 mg of active ingredients.

The most popular forms of release that doctors and their patients most often deal with are Biseptol 480 mg in the form of tablets and Biseptol 240 mg suspension for children.

>>Recommended: if you are interested in effective methods of getting rid of chronic rhinitis, pharyngitis, tonsillitis, bronchitis and persistent colds, then be sure to check out this website page after reading this article. The information is based on the personal experience of the author and has helped many people, we hope it will help you too. Now back to the article.<<

How Biseptol works - pharmacological action

Sulfamethoxazole is the main component of Biseptol, which has a fairly strong bactericidal effect. It disrupts the synthesis of dihydrofolic acid, necessary for microorganisms to live. Trimethoprim enhances the effect of sulfamethoxazole. Synergy, that is, the summation of the effects of Biseptol components, was first described in the late 60s.

The ratio in which the components are dosed is precisely verified. If in a Biseptol tablet it is approximately one to five, then when absorbed into the blood, the ratio of sulfamethoxazole and trimethoprim drops to one to twenty. These concentrations are necessary for the peak, maximum synergistic effect of the components.

Does Biseptol still have anything to do with antibiotics or not?

This question worries patients so often that it is simply necessary to dot the i's. So, an antibiotic is a medicinal substance of natural (animal, plant or microbial) origin, which has an antibacterial effect, completely suppressing both the growth and reproduction of bacteria. The modern pharmaceutical industry also produces semi-synthetic antibiotics.

Upon careful study of the instructions for Biseptol, it becomes obvious that its components have nothing to do with antibiotics. Both substances that make up the drug are synthesized in the laboratory. Sulfamethoxazole belongs to the group of sulfa drugs, and trimethoprim is used exclusively to enhance the effect of the main component.

The answer to the question whether Biseptol belongs to antibiotics or not is unambiguous and beyond doubt. Biseptol is a medicine from the group of sulfonamides with antibacterial action. But not an antibiotic.

However, it is naive to believe that a remedy that is not related to the notorious “harmful” antibiotics is as safe as multi-colored sweet vitamins. Sulfonamides are also serious drugs that should be taken exclusively under the supervision of a doctor. Otherwise, you may expect not very pleasant consequences, including the formation of drug-resistant microorganisms. After all, it is not for nothing that all antibacterial agents - antibiotics, sulfonamides, and representatives of other pharmacological groups - are prescription drugs. And you shouldn't forget about it.

Biseptol: indications for use

The answer to a common and seemingly simple question, what does Biseptol help with, cannot be unambiguous. After all, the combination of sulfamethoxazole and trimetroprim is a serious drug, the selection of which requires careful collection of information. Ideally, if this is done by a specialist. Let's try to figure out in which cases Biseptol is the drug of choice and when it is better to prefer another medicine to it.

The main indications for the use of Biseptol are, of course, diseases caused by pathogenic microorganisms. The spectrum of action of the sulfamethoxazole-trimethoprim complex is quite wide and includes a wide variety of gram-positive, gram-negative bacteria, protozoa and even pathogenic fungi. Streptococci, staphylococci, Escherichia coli, Salmonella, Chlamydia, Toxoplasma and other microorganisms are exposed to the bactericidal action of the drug. Tuberculosis bacillus, treponema, leptospira, pathogenic viruses are resistant to Biseptol.

A fairly wide range of microorganisms sensitive to Biseptol determines the same extensive list of diseases for which the drug is used. Let's try to figure out in what cases this drug is prescribed.

The most common gram-positive bacteria that commonly cause upper and lower respiratory infections are staphylococci and streptococci. The high efficiency of Biseptol against these microorganisms allows it to be successfully used in bacterial pharyngitis and tonsillitis - tonsillitis.

Biseptol also gives positive results with bacterial bronchitis. However, I would like to note that inflammation of the bronchi is often caused by viruses that are resistant to the action of antibacterial drugs. Therefore, be prudent: when a cough appears, you should not drink such drugs without the recommendation of a doctor.

Inflammation of the maxillary sinuses - sinusitis - most often caused by all the same cocci, less often - chlamydia, mycoplasmas and viruses. Despite the fact that antibiotics are the drugs of choice for sinusitis, Biseptol is sometimes prescribed.

Is the treatment of intestinal infections justified?

The activity of the drug against Escherichia coli allows the use of Biseptol in acute intestinal infections. It is important that the effect of the drug extends to enterotoxigenic strains of the pathogen. Enterotoxigenic E. coli is responsible for severe bloody diarrhea that is accompanied by general intoxication of the body. In addition, there is experience with the use of the drug in salmonellosis.

However, before deciding to use any antibacterial agent for intestinal infections, one important nuance should be remembered. All pathogens of these diseases are eliminated on their own within a week. In plain language, a week after infection, the disease will stop without any treatment. This also applies to the notorious salmonellosis, one diagnosis of which sometimes leads the patient and his relatives into a state of panic.

Standard protocols for the treatment of acute intestinal infections do not include the use of any antibacterial drugs. The basis of the treatment of such diseases is to ensure sufficient fluid intake.

In severe cases (for example, with the development of infection in young children or the elderly, in immunocompromised patients), it is still possible to prescribe antibacterial drugs. And again, Biseptol is not the gold standard in such cases - there are many other, safer drugs. For example, funds from the group of nitrofurans are not absorbed into the blood at all. The effectiveness and safety of these drugs is based on the fact that they work only in the intestinal lumen.

Therefore, in the vast majority of cases, Biseptol treatment of intestinal infections is absolutely unjustified.

Urinary tract infections

Escherichia coli is recognized as the most common cause of urinary tract infections. Approximately 80% of all inflammatory processes of the bladder are caused by this pathogen. Therefore, Biseptol, which is active against Escherichia coli, in some cases gives good results with cystitis.

However, it should be remembered that the antibiotic of the fluoroquinolone series is still the drug of choice for diseases of the urinary tract. It is impossible to approach the treatment of these pathologies negligently: with inadequate therapy, there is a rather high risk of chronicity of the pathological process. Untreated cystitis threatens with chronic inflammation of the bladder, which is difficult to treat.

Why is the uncontrolled use of Biseptol dangerous for cystitis? In fact, everything is very simple: the frequent use of Biseptol for a long time led to the gradual emergence of resistance to the components of the drug. As a result, the effectiveness of the drug has decreased significantly.

In the treatment of many infections, the relief received at the beginning is taken by the patient for a complete cure. In fact, with the uncontrolled use of Biseptol, and other antibacterial drugs, there is a possibility that some particularly resistant microorganisms survived. With this development of events, the disease passes into a latent chronic phase. Chronic cystitis may not appear for some time, and this is its particular danger.

So it's not worth the risk. Cystitis and other diseases of the urinary tract should be treated by a doctor, and uncontrolled intake of Biseptol in these pathologies can be fraught with complications.

Biseptol for colds: necessary, contraindicated or useless?

One of the most common misconceptions of Russian patients is blind faith in the mighty power of antibiotics for any disease. It is impossible to link this confidence with objective reasons. Our citizens stubbornly want to treat influenza, colds and SARS with antibiotics. The worst thing is that often caring mothers conduct these experiments with their children.

Let's look at this, of course, an important issue. Do you need antibacterial drugs, which include Biseptol, for a cold or SARS?

To do this, first of all, it is necessary to remember that the common cold, the flu, and an acute viral disease - ARVI - are caused by various viruses. And we already know that Biseptol, like any other antibacterial agents, does not affect viruses. Absolutely. Thus, using it for a cold, we will not get any effect. Except for the side.

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A common cold or SARS usually goes away on its own within a week or a little more. However, in debilitated patients, young children, elderly patients - all those who have malfunctions in the immune system - the disease can take a protracted course. This leads to a complication of the pathology and additional infection with bacteria. In such cases, as a rule, an antibacterial drug is needed. And the use of Biseptol tablets will be very appropriate.

How to notice this line between a viral and already complicated viral-bacterial infection? For a person far from medicine, this is indeed not so simple. One of the symptoms of a complicated viral disease is a sharp deterioration in the condition. For example, a significant increase in temperature after several days of illness and a period of relative calm. In this case, the fever either does not stop at all, or after taking antipyretics, the temperature drops very slowly and for a short time. The appearance of a strong cough, accompanied by sputum discharge, may indicate a complication of the infection. The treatment of a cold aggravated by a bacterial infection should be handled by a doctor who will select the correct antibacterial drug.

The course of treatment with Biseptol is selected individually for each patient.

For children, the drug is prescribed starting from 6 weeks of age. Young children are usually prescribed a suspension or syrup. Most often, pharmacies sell a suspension of Biseptol, in the annotation to which the recommended treatment regimen is clearly described, depending on the age of the child.

The standard dosage of Biseptol for children from six months to five years is 240 mg twice a day. 5 ml of suspension or syrup contains exactly 240 mg of sulfamethoxazole and trimethoprim, so it is very convenient to dose the drug. Even if you lose the measuring spoon that usually comes with the medicine, there will be no problem with taking it. After all, a standard teaspoon contains exactly 5 ml of solution. One teaspoon of Biseptol suspension or syrup in the morning and evening is enough for the child to receive a daily dose of sulfamethoxazole and trimethoprim.

If the child is able to swallow a pill, he is prescribed a tablet form of Biseptol at a dose of 120 mg. Children under 5 years old take 2 tablets at once twice a day.

Starting from the age of 6, the drug is prescribed at a dose of 480 mg twice a day, and it is most convenient to buy Biseptol tablets.

Starting from the age of 12, Biseptol is prescribed at a dose of 960 mg. Multiplicity of application - twice a day.

The course of treatment is selected depending on individual factors and can range from 5 days to two weeks. In severe cases, the doctor has the right to prescribe doses that exceed the standard recommended by 50%.

Features of the use of suspensions

I would like to draw attention to the features of taking Biseptol suspension. Usually the manufacturer tries to warn the patient about the need to shake the vial before using the medicine. And unfortunately, not everyone complies with this requirement. Why is it so important to read the annotation to Biseptol to the end and do not forget to shake the vial with the suspension?

Any suspension is a two-fraction system in which the active substance is present in an undissolved form. It is evenly distributed only after vigorous shaking. Otherwise, you run the risk of drinking a teaspoon of a suspension containing not 240 mg of Biseptol, but much less, and it is not possible to establish the exact mass.

If you bought Biseptol syrup, you can safely give it to your child without first manipulating the bottle - the syrup is absolutely homogeneous.

And finally. All children's forms of Biseptol - both syrup and suspension - have a pleasant taste. Children are usually happy to be treated with such "edible" medicines, so be careful and keep the drug out of reach.

Admission rules, or How to drink Biseptol?

Therapy with any medication should not be chaotic. If you have to drink antibiotics or sulfonamide antibacterial drugs, you should be especially attentive to treatment. Both the effectiveness of the drug and the likelihood of adverse events depend on compliance with the rules of admission.

How to drink Biseptol? You just need to remember the following rules:

  • it is necessary to observe a 12-hour interval between doses. For example, take the morning dose at 8 am and the evening dose at 8 pm. Non-compliance with the regimen threatens to reduce the antibacterial activity of Biseptol;
  • you need to drink the drug (both tablets and suspension) only after meals. Otherwise, the medicine has an irritating effect on the walls of the stomach;
  • the minimum course of therapy should be at least five days. All lovers of treatment in three days should arm themselves with patience. Otherwise, you risk getting a complication of the infection, which, moreover, will be difficult to respond to antibiotic therapy.

Side effect

If you carefully read the instructions for Biseptol, the abundance of information about the side effects of the drug can shock even the most sophisticated reader. But in practice, things are not so threatening.

As a rule, at the recommended doses, both tablets and Biseptol suspension are well tolerated. Side effects that are recorded most often do not usually require discontinuation of the drug. Among the most common adverse events, I would like to note:

  • dermatological manifestations in the form of rash and urticaria. Allergic reactions are more common in sensitized (sensitive) patients;
  • violation of the gastrointestinal tract: nausea, occasionally - diarrhea, loss of appetite, stomatitis.

With prolonged use of high dosages of Biseptol, side effects may be more pronounced. Serious allergic reactions are occasionally recorded, candidiasis may develop due to changes in the composition of the intestinal microflora.

I would like to reassure those patients who, having read the instructions for Biseptol to the section “Side Effects” and horrified, make a responsible decision to be treated with folk, and not “harmful” medicine.

The list of side effects includes all the symptoms that were recorded during the trials of the drug. The number of patients participating in clinical trials is usually several thousand people. Post-marketing trials last throughout the entire period of drug sales. Each patient is a potential participant in these studies, and the fact that he has a new side effect will be recorded in the annotation. Therefore, the likelihood of most side effects in the light of large numbers is extremely small. So, the manufacturer of Biseptol describes the possibility of hematopoietic disorders, but if the recommended doses are observed, this effect is observed only in one of several hundred patients.

Contraindications

Biseptol is prescribed for the treatment of children, but it is not recommended to use the drug in infants under six weeks of age. In addition, Biseptol is categorically contraindicated during pregnancy and lactation. Sulfamethoxazole and trimethoprim perfectly penetrate the placental barrier. High doses of Biseptol components are also found in breast milk. Therefore, pregnant and lactating women will have to select other, safer antibacterial agents.

In addition, Biseptol is contraindicated in patients with severe diseases of internal organs: liver, kidneys, as well as hematopoietic disorders.

Separately, I would like to note individual sensitivity to sulfanilamide drugs as a contraindication. The likelihood of an individual reaction is usually extremely small and possible in sensitized patients. Be careful when taking Biseptol if you have ever had allergic reactions to medications (for example, an allergic rhinitis). For the same patients who have experienced any manifestations of sensitivity to streptocide, fthalazole, sulfadimethoxine, Biseptol is categorically contraindicated. The likelihood of an allergy in this case is very high!

If side effects occur during treatment, it is very important to inform your doctor immediately.

When does Biseptol not work?

I would especially like to note that with angina caused by beta-hemolytic streptococcus, Biseptol is not recommended for use. The fact is that strains of group A hemolytic streptococcus are almost completely resistant to sulfa drugs. For a long period of therapy with antibacterial drugs, microorganisms have formed on which sulfamethoxazole does not have a bactericidal effect.

An error in the selection of the drug for tonsillitis can lead to complications, especially in young children. That is why an examination and consultation of a doctor is necessary: ​​only a specialist can distinguish streptococcal tonsillitis from staphylococcal.

A question of choice, or how to replace Biseptol?

The pharmaceutical market is usually saturated with analogues that can fully replace the drug. Often it is difficult even for a doctor to understand the abundance of different drugs. And a person who is not related to medicine, an excessive abundance of analogues or generics can be confusing. Let's try to figure out what can replace Biseptol in Russia.

Most often, it is Biseptol in pharmacies that is sold in tablets and children's suspensions made in Poland. A fairly common drug from the French company Seneksi Bactrim is also not inferior in quality to the original remedy. The Russian company Pharmstandard produces a cheaper analogue of Biseptol in tablets and suspensions - Co-trimoxazole at a dose of 480 mg and 240 mg, respectively. Medicines under the same name are produced by other Russian pharmaceutical companies. All of them are democratically priced.

The remaining modern analogues of Biseptol are extremely rare. Sometimes pharmacies offer very high-quality Dutch Bi-septin tablets (manufacturer NaturProduct) and Septrin, produced by the world-famous English concern Glaxo.

The use of drugs that have a strong antibacterial effect makes it possible to eliminate diseases caused by pathogenic fungi, protozoa, gram-positive and gram-negative bacteria. Biseptol tablets are a drug with a bactericidal effect: it provokes the death of a microbial cell by blocking the synthesis of folic acid, without which it loses its ability to divide. This drug does not belong to the group of antibiotics. Biseptol is produced in the form of tablets, syrup and suspension. The last two forms mentioned are usually recommended for the treatment of children. Each dosage form has features of administration and dosage, therefore, before starting treatment, it is necessary to obtain an exhaustive consultation of a specialist. It should be noted: the drug is dispensed by prescription.

Biseptol - a drug with an extensive range of action, belongs to the group of bactericides. It is prescribed to eliminate microbes that cause infectious diseases.

Characteristics of the drug

Biseptol tablets are a combination drug that is characterized by a wide spectrum of action. It contains sulfamethoxazole, which disrupts the synthesis of the acid necessary for the development of bacteria, as well as trimethoprim, a substance that enhances the effect of the first active ingredient and prevents the reproduction of pathogenic microorganisms.

Biseptol is effective in many pathologies, the effect appears soon - on the second day of treatment, an improvement is noted

This medication is active against pathogens such as:

  • gonococci;
  • meningococci;
  • chlamydia;
  • salmonella;
  • coli;
  • some types of fungi.

Note! Biseptol does not act on viruses, so it is not used to treat viral diseases. The drug is also not active against pathogens and leptospirosis, Pseudomonas aeruginosa, spirochetes.

This medication is produced not only in the form of tablets - Biseptol suspension, syrup and ampoules containing a concentrate are also available. Biseptol suspension is suitable for children; the drug contained in ampoules is used exclusively during inpatient treatment under the supervision of medical personnel.

Tablets and other forms of the drug are rapidly absorbed from the stomach, and their active components have the ability to penetrate into the tissues and body fluids - into the kidneys, tonsils, lungs, bronchial secretions, cerebrospinal fluid.

The maximum concentration of the active components of the drug in the blood is observed 60 minutes after its administration.

Indications and contraindications for taking the drug

Treatment with Biseptol is effective in the treatment of acute infectious diseases of the respiratory tract, infections of the ENT organs and the gastrointestinal tract, diseases of the urinary tract and organs of the reproductive system. Also, the use of the drug is advisable for infections of the skin and soft tissues.


Biseptol is prescribed for infectious and inflammatory diseases of the urinary and reproductive systems.

Indications for taking Biseptol are the following diseases and pathologies:

  • acute and chronic;
  • lung abscess;
  • malaria;
  • scarlet fever;
  • brucellosis;
  • toxoplasmosis;
  • acne;
  • brain abscess;
  • pyoderma;
  • salmonellosis;
  • typhoid fever;
  • osteomyelitis;
  • cholera.

Even having an idea of ​​​​what Biseptol helps from, you should not take it without a doctor's prescription. This drug has some absolute contraindications. These include:

  • children's age up to 3 months (for taking a suspension) or 3 years (for taking tablets);
  • impaired renal function;
  • hypersensitivity to the active substances of the drug;
  • the period of gestation and breastfeeding;
  • hematopoietic disorders;
  • deficiency of folic acid in the body;
  • liver failure;
  • cardiovascular failure.

Note! If the patient has previously experienced an allergic reaction to taking certain medications, Biseptol is prescribed with caution, and treatment in this case is carried out under the special supervision of a physician. Also, tablets are prescribed with caution in case of thyroid diseases, at an early and advanced age.

When a patient is recommended to drink Biseptol, he is necessarily warned about the likelihood of adverse reactions. Although in most cases this drug is well tolerated by patients, the following undesirable manifestations may occur:


With prolonged use of high dosages of Biseptol, side effects may be more pronounced. Serious allergic reactions are occasionally recorded, development is possible due to changes in the composition of the intestinal microflora
  • nausea;
  • abdominal pain;
  • apathy;
  • depression;
  • dizziness;
  • trembling fingers;
  • an increase in the volume of urine excreted;
  • feeling short of breath;
  • pain in muscles and joints;
  • temperature increase;
  • chills;
  • skin itching.

Biseptol is contraindicated in patients with severe diseases of the internal organs - the liver, kidneys, as well as hematopoietic disorders

Side effects, if they occur, are mild.

Note! Particular care in the treatment of Biseptol must be observed in the elderly, as well as in persons suffering from alcoholism or malabsorption of substances.

Biseptol tablets are available in dosages of 120 and 480 mg. The difference between them is that the first type of drug contains sulfamethoxazole in the amount of 100 mg and trimethoprim in the amount of 20 mg; in the preparation with a dosage of 480 mg - 400 mg and 80 mg of substances, respectively.


Each package contains 20 tablets.

Instructions for Biseptol tablets prescribe the following:

  • reception is carried out after a meal;
  • to prevent the formation of crystals in the urine that provoke urolithiasis, it is necessary to drink tablets with plenty of water, and throughout the course of treatment, drink at least 2 liters of pure water daily;
  • during therapy, limit exposure to direct ultraviolet rays;
  • when taking tablets, adults and children should limit the intake of protein foods, which reduces the effectiveness of the drug;
  • it is important to stop drinking alcoholic beverages, which not only neutralize the effectiveness of the medication, but can also cause the development of allergic reactions.

Before starting treatment, the specialist should explain to the patient how to take Biseptol. The dosage of the drug depends on the existing disease:

  • Biseptol for cystitis, other diseases of the urinary tract of an infectious nature, as well as chronic in adults, is taken according to the following scheme: 960 mg of the drug per day, which is equal to 2 tablets at a dosage of 480 mg or 8 tablets at a dosage of 120 mg. You need to take the tablets 2 times a day. Biseptol is taken in the same way;
  • with gonorrhea, 1920-2880 mg of the drug per day is indicated. The indicated dosage is divided into 3 doses per day;
  • with diarrhea, it is recommended to take 960 mg of the drug, in two divided doses. Between each of them must pass 12 hours.

The minimum period of use of this medication is 4 days. It is not recommended to continue therapy for more than 2 weeks, since prolonged use of Biseptol provokes a violation of the synthesis of folic acid, and this, in turn, can lead to hematopoietic disorders.

When treating, it is important not to exceed the rate of the drug prescribed by the doctor. An overdose of Biseptol can cause the following symptoms:


An overdose of Biseptol can greatly affect the general condition of the patient. This is manifested by frequent headache and dizziness. In some cases - aseptic and depression. With such symptoms, you should consult a doctor
  • drowsiness;
  • nausea and vomiting;
  • fever;
  • pre-fainting state;
  • the appearance of blood in the urine;
  • jaundice;
  • depression;
  • hematopoietic disorders.

If signs of an overdose appear, the patient is assisted in the form of gastric lavage, intramuscular injections of folinate, acidification of urine.

Can children take Biseptol tablets?

Can Biseptol be used in childhood? If it is necessary to take this drug, Biseptol for children is recommended in the form of a suspension. It can be given to a child from the age of 3 months. Biseptol syrup is recommended to be given from the age of 1 year. As for the medication in tablets, it can be used from the age of 3 years. Parents are often concerned about the question of whether Biseptol is an antibiotic or not. This remedy does not belong to the group of such drugs, but its use must be discussed with a doctor.


How many milligrams should the dose of the drug be? Instructions for the use of Biseptol for children provide for the following:

  • at the age of 3 to 5 years, the daily dose of tablets will be 240 mg (2 tablets with a dosage of 120 mg);
  • children from 6 to 12 years old are given 480 mg of the drug per day (4 tablets of 120 mg or 1 at a dosage of 480 mg);
  • at the age of 12 years and older, the allowable daily dose can reach 960 mg per day. The daily intake is divided into 2 times.

When taking Biseptol by a child, it is important for parents to control his condition. If adverse reactions occur, you should immediately contact a specialist. On the advice of a doctor, you can supplement the treatment with vitamin and dietary supplements that mitigate the negative effect of the drug on the functioning of the intestines and kidneys.

Analogues

Analogues of the drug Biseptol 480 for the active substance are:

  • Bactrim;
  • Disepton;
  • Intrim;
  • Cotrimoxazole;
  • Trimezol;
  • Ziplin;
  • Sumetrolim;
  • Oriprim;
  • Duo-Septol;
  • Cotrifarm;
  • Berlocid;
  • Bisutrim.

The price of the drug Biseptol is from 27 to 40 rubles for a package of tablets with a dosage of 120 mg and from 80 to 110 rubles for a package of tablets with a dosage of 480 mg.

The drug is dispensed exclusively by prescription and is taken according to his instructions.

Attention everyone who uses Biseptol 480: instructions for use of this drug should be carefully studied! The dosage prescribed by the doctor should never be exceeded, otherwise there is a significant risk of side effects.

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