Desal drops instructions for use. Desal is an effective fight against all types of allergies. Positive effect on the body

Desal is given to children with allergies. It is a classic antihistamine agent that acts on the reception of the allergen by histamine receptors. It activates the suppression of toxic reactions in allergy-prone cells, enhances the synthesis of anti-inflammatory substances.

Desal is effective for seasonal acute manifestations of allergies, pollinosis, urticaria and itching.

Animal studies of the drug show very good results in the fight against acute bronchospasm of an allergic nature and the primary manifestations of an allergy and its symptoms. The active ingredient is desloratadine,

Instructions for the drug include the following indications:

• Acute bronchospasm;
• Manifestation of pollinous rhinitis;
• Congestion with allergies;
• Itching of the mucous membranes of the nasopharynx;
• Skin itching;
• Redness of the eyeballs, eyelids and increased tearing from the tear ducts;
• Idiopathic urticaria;
• Manifestations of symptoms of an allergy of an unknown nature.

The bronchi are the structural and functional unit of the lung. The pulmonary tree is built from many bronchi. The bronchi tend to relax and contract, which leads to the process of breathing and gas exchange. Spasm of the bronchus leads to insufficient oxygenation of the blood and suffocation, and in the worst case, death.

The drug affects the reception of the allergen by the epithelium of the bronchi and stops the spasm, allowing the person to continue breathing freely.

Idiopathic urticaria has the same processes as allergic urticaria, with the difference that it is not always allergic in nature. Antihistamines are also used to treat it, which reduce the secretion of epithelial cells and relieve symptoms.

Forms of the drug

Desal is available in the form of tablets and oral solution. The tablets are coated with a lactose shell, with a small amount of starch, cellulose, magnesium and talc. Contains 5 milligrams of desloratadine, the active ingredient, in each tablet.

The syrup is available in 50, 60, 100, 120, 150 and 300 milliliter bottles. The syrup in each milliliter contains 0.5 milligrams of desloratadine. In addition, the composition contains propylene glycol, sodium citrate, sucralose and other substances. Flavored and fruity.

Deloratadine itself is produced not only under this brand, but also under other names and in other forms. If necessary, you can consult a doctor, as drops or injections may be more suitable for a child.

Dosage

Tablets and syrup are consumed regardless of the meal, 1 time per day. It is undesirable to divide the dose into two times, as this may interfere with the action of the drug.

Syrup for oral administration is produced complete with measuring spoons of 2.5 and 5 milliliters, which help to take the drug in a convenient dosage. Children from one year to 5 years should be given 2.5 milliliters of solution once a day. From 6 years to 11 - 5 milliliters.

Adults and teenagers can take 10 milliliters per day.

Tablets for children under 12 years of age are not recommended by the instruction, but if admission is necessary, it is important to consider that one tablet contains 5 milligrams of desloratadine. Children from one year to 6 can be given a quarter tablet once a day, and children from 6 to 12 - half. Teenagers and adults may take one tablet once daily.

Side effects

Desal is one of the safest antihistamines, because adverse reactions were extremely rare. The main manifestation of side effects occurred with increased sensitivity of the body to the drug.

Among them:

• Dizziness, manifestation of drowsiness or, conversely, insomnia;
• Tachycardia;
• Abdominal pain, vomiting, nausea;
• Diarrhea;
• Hepatitis;
• Allergic reactions to the drug.

The most common adverse reaction was increased fatigue and the occurrence of dryness of the mucous membranes of the nasopharynx. This applies to both solution and tablets. In general, the development of adverse syndromes in both children from one year and older and in adults did not exceed the results of the "placebo" test, so we can talk about the safety of this drug.

The development of hepatitis is due to the beginning of the degeneration of the liver. The instruction of the drug shows that the drug is metabolized by the liver, excreted through urine and feces in the form of a compound with glucose and in a small amount - unchanged.

Before using the drug, be sure to consult a doctor, as this can cause serious consequences for the body.

If the organisms of your children do not have an affinity for the drug, then adverse allergic reactions may develop in the form of idiopathic rhinitis and conjunctivitis. With extreme intolerance to the drug may occur. Try not to exceed the indicated dosage.

If the drug does not help in the fight against the disease, and the symptoms only get worse, stop taking it immediately.

Contraindications

For children under one year old, there are not enough studies on the safety and effectiveness of the drug. Therefore, a conditional contraindication can be called children's age up to a year.

Also, like any antihistamine drug, care should be taken when using the drug for renal failure, both severe and moderate. Anuria, which develops with these diseases, can be aggravated by the drug and lead to intoxication of the body.

Give Desal with caution to children who have hereditary diseases associated with stomach and intestinal enzymes. These include fructose intolerance, poor intestinal absorption of glucose, and intestinal sucrase/isomaltase deficiency.

The tablets should not be given to children with lactose intolerance as they may cause diarrhea and flatulence. Do not start taking without a doctor's prescription as this may harm your child.

Overdose

In tests, an overdose of 9 times showed the absence of clinically significant health symptoms. It was noted the development of excessive drowsiness, not dangerous to the body.

In case an overdose does occur, the child should be vomited. Blood dialysis and bowel lavage do not give sufficient results in removing the drug from the body.

Price

Desal is dispensed in a pharmacy without a prescription, the price of syrup for 100 ml fluctuates at the level of 290 rubles, depending on the pharmacy, for tablets - 200 rubles for a package with a blister of 10 tablets. Desal is an excellent tool without strong side effects, so it can be used without fear. The instruction is attached to each box with the drug.

Before using any drug, it is necessary to consult a pediatrician treating your child, since all side effects and the body are much more known to a person with a medical education. Resort to self-medication only as a last resort.

Desal tablets- a long-acting antihistamine drug, a blocker of peripheral H1-histamine receptors. Desloratadine is the primary active metabolite of loratadine. Inhibits the cascade of allergic inflammation reactions, incl. release of pro-inflammatory cytokines, including interleukins IL-4, IL-6, IL-8, IL-13, release of pro-inflammatory chemokines, production of superoxide anions by activated polymorphonuclear neutrophils, adhesion and chemotaxis of eosinophils, release of adhesion molecules such as P-selectin, IgE - mediated release of histamine, prostaglandin D2 and leukotriene C4. Thus, it prevents the development and facilitates the course of allergic reactions, has antipruritic and antiexudative effects, reduces capillary permeability, prevents the development of tissue edema, smooth muscle spasm. The drug has no effect on the central nervous system (CNS), has practically no sedative effect (does not cause drowsiness) and does not affect the speed of psychomotor reactions when taken in recommended doses. Does not cause prolongation of the QT interval on the electrocardiogram.
The action of desloratadine begins within 30 minutes after ingestion and lasts for 24 hours.

Pharmacokinetics

After oral administration, desloratadine is well absorbed from the gastrointestinal tract. It is determined in the blood plasma after 30 minutes, and the maximum plasma concentration (Cmax) is reached after approximately 3 hours. There were no clinically significant changes in the concentration of desloratadine in the blood plasma with repeated administration of ketoconazole and erythromycin. The bioavailability of desloratadine is dose-proportional with doses ranging from 5 mg to 20 mg.
Communication with plasma proteins is 83-87%. When used in adults and adolescents for 14 days at a dose of 5 mg to 20 mg 1 time / day, there are no signs of clinically significant cumulation of desloratadine. The degree of accumulation of desloratadine is consistent with the value of the half-life (T1 / 2) and the frequency of its use once a day. The values ​​of the area under the pharmacokinetic curve "concentration-time" and Cmax in children were similar to those in adults who received 5 mg of desloratadine.
Simultaneous ingestion of food or grapefruit juice does not affect the distribution of desloratadine (when taken at a dose of 7.5 mg 1 time / day). Does not penetrate the blood-brain barrier.
The enzymes responsible for the metabolism of desloratadine are not yet known, so interactions with certain drugs cannot be completely ruled out. It is not an inhibitor of CYP3A4 and CYP2D6 and is not a substrate or inhibitor of P-glycoprotein. Intensively metabolized in the liver by hydroxylation to form 3-OH-desloratadine, which is then glucuronized.
The terminal phase T1 / 2 is about 27 hours. Desloratadine is excreted from the body in the form of a glucuronide compound and in a small amount unchanged (by the kidneys - less than 2% and through the intestines - less than 7%).

Indications for use

Recommended tablets Desal take to relieve or eliminate symptoms of: allergic rhinitis (sneezing, nasal congestion, rhinorrhea, itchy nose, itchy palate, itchy and red eyes, watery eyes); urticaria (skin itch, rash).

Mode of application

Desal tablets take orally, regardless of the meal.
Adults and adolescents (12 years and older) - 1 tablet 5 mg 1 time per day.

Side effects

More often than others, the following adverse reactions are noted: increased fatigue (1.2%), dryness of the oral mucosa (0.8%), headache (0.6%).
When using the drug in adults and adolescents at the recommended dose of 5 mg / day, the incidence of drowsiness is not higher than when using placebo.
During post-marketing surveillance, the following adverse reactions were very rarely noted.
Mental disorders: hallucinations.
From the side of the central nervous system: dizziness, drowsiness, insomnia, psychomotor hyperactivity.
From the side of the cardiovascular system: tachycardia, palpitations.
From the digestive system: abdominal pain, nausea, vomiting, dyspepsia, diarrhea.
From the side of the liver and biliary tract: increased activity of liver enzymes, increased concentration of bilirubin, hepatitis.
From the musculoskeletal system: myalgia.
Allergic reactions: anaphylaxis, angioedema, itching, rash, urticaria.

Contraindications

:
Contraindications to the use of the drug Desal are: hypersensitivity to the active or any excipient of the drug; pregnancy; breastfeeding period; age up to 12 years (efficacy and safety have not been established).
With caution - severe renal failure.

Pregnancy

:
Application of the drug Desal during pregnancy is not recommended due to the lack of clinical data on the safety of its use in this period.
Desloratadine is excreted in breast milk, so its use during breastfeeding is not recommended.

Interaction with other drugs

Clinically Significant Interaction Desala tablets with other drugs have not been identified (including ketoconazole and erythromycin).
Desloratadine does not enhance the effect of ethanol on the central nervous system.

Overdose

:
Symptoms: 9 times the recommended dose (45 mg) did not result in any clinically significant symptoms. Perhaps the development of drowsiness.
Treatment: it is necessary to wash the stomach, take activated charcoal; if necessary - symptomatic therapy. Desloratadine is not excreted by hemodialysis, the effectiveness of peritoneal dialysis has not been established.

Storage conditions

In a dry, dark place, at a temperature not exceeding 25 ° C.
Keep out of the reach of children!

Release form

Film-coated tablets 5 mg. 10 tablets in a blister Al / Al.
1, 2 or 3 blisters along with instructions for medical use in a cardboard box.

Compound

:
1 tablet Desal coated contains: active substance: desloratadine 5.00 mg.
Excipients: microcrystalline cellulose 55.00 mg, pregelatinized corn starch 15.00 mg, mannitol 22.00 mg, talc 2.50 mg, magnesium stearate 0.50 mg.
Film shell: Opadry blue 03F20404 (hypromellose 6cP - 1.90 mg, titanium dioxide (E 171) 0.61 mg, macrogol 6000 - 0.34 mg, dye indigo carmine aluminum varnish (E 132) 0.14 mg) about 3, 00 mg.

Additionally

:
In case of severe impairment of renal function, the drug Desal should be taken with caution.
Influence on the ability to drive vehicles and mechanisms
Studies have not noted the effect of desloratadine on driving. However, it should be borne in mind that very rarely, some patients may develop drowsiness, in this case, care should be taken when driving vehicles and when working with mechanisms.

main parameters

Name:	DEZAL TABLETS
ATX code:	R06AX27 -

November 10, 2015

How to use the drug "Dizal"? Instructions for using this tool will be presented below. You will also learn about what components are included in the mentioned medication, in what form it is produced, whether it can be prescribed to children and pregnant women.

Table of contents [Show]

Composition, form, description of the medicinal product

What components does the drug "Dizal" include? Allergy tablets, the instructions of which are enclosed in a cardboard package, are blue, biconvex and round in shape, as well as engraved "LT" on one side. The active ingredient in this medication is desloratadine. It also contains additional ingredients in the form of microcrystalline cellulose mannitol, pregelatinized corn starch, magnesium stearate and talc.

As for the film shell of the tablets, they include opadra blue, macrogol and indigo carmine dye.

It should also be noted that the drug in question is available in the form of a syrup. Its active substance is also desloratadine.

Pharmacology

How does the drug "Dizal" (allergy pills) work? The instructions that come with this remedy say that this is a long-acting antihistamine. It is a blocker of peripheral histamine H1 receptors.

The active substance of this medication is the primary active metabolite of loratadine. It inhibits allergic reactions by releasing pro-inflammatory cytokines and chemokines. Also, this component reduces the production of superoxide anions, chemotaxis and adhesion of eosinophils.

This effect of the drug helps to prevent the development and alleviate allergic reactions. The drug in question has antiexudative and antipruritic properties, prevents the development of spasms of smooth muscles, tissue edema and reduces capillary permeability.

Tablets "Dizal", the price of which will be indicated below, does not have any effect on the central nervous system, and also does not have a sedative effect (that is, does not cause drowsiness) and does not affect the psychomotor reaction of a person (when taking the recommended dosages). In addition, the drug in question does not lengthen the QT interval on the ECG.

The therapeutic effect of this drug begins within half an hour after ingestion and lasts throughout the day.

Pharmacokinetics

What pharmacokinetic indicators does the drug "Dizal" (allergy pills) have? The instruction reports that after taking the drug, its active substance is well absorbed from the gastrointestinal tract. In plasma, it is determined after half an hour, and its maximum concentration is reached after about three hours.

Communication with plasma proteins of the drug is 85-87%, and the half-life is about 28 hours. Desloratadine is excreted from the body through the intestines (less than 7%) and together with urine (less than 2%).

Indications for use

From allergies on the face, this drug helps very well. It is used not only to relieve, but also to eliminate the following symptoms:

• urticaria (rash and pruritus);
• allergic rhinitis (rhinorrhea, sneezing, itchy palate, nasal congestion, redness and itching of the eyes, itchy nose, watery eyes).

Contraindications for use

From allergies during pregnancy, the drug "Dizal" is prohibited to use. Also, it is not prescribed for breastfeeding and in children under 12 years of age (safety and efficacy have not been established). Do not use this medication and with increased sensitivity of the patient to the current or any additional ingredient of the drug.

With extreme caution, tablets "Dizal" are prescribed for severe renal failure.

The drug "Dizal" (allergy pills): instructions

Only a narrow specialist should prescribe such tablets. Allergies (urticaria, itching, rash, etc.) in children from 12 years of age and adult patients are eliminated in the same way. According to the instructions, the tablets must be taken orally, regardless of the meal. The dosage of this medication is determined by the doctor and, as a rule, it is 5 mg once a day (that is, 1 tablet per day).

Adverse reactions

From allergies for children over 12 years old, the drug "Dizal" should be administered with extreme caution. This is due to the fact that this medication can cause a large number of side effects.

More often than others, patients experience such undesirable reactions as increased fatigue, persistent headaches and dryness of the oral mucosa.

In the course of observations, other side effects were also identified. Let's introduce them right now:

• From the side of the nervous system, drowsiness, psychomotor hyperactivity, dizziness and insomnia may be noted.
• From the digestive tract, abdominal pain, diarrhea, nausea, dyspepsia and vomiting are observed.
• On the part of the biliary tract and liver, phenomena such as an increase in the concentration of bilirubin, an increase in the activity of liver enzymes and hepatitis occur.
• From the side of the heart and blood vessels, patients are worried about tachycardia and a feeling of palpitations.
• From the side of the bone and muscular system, myalgia is observed.

It should also be noted that while taking the drug in question, patients may experience mental disorders in the form of hallucinations and allergic reactions in the form of itching, anaphylaxis, rash, angioedema and urticaria.

Signs of an overdose

From allergies for children over 12 years old, as well as adults, the drug "Dizal" should be taken in the dosages recommended by the doctor.

When taking the drug in higher doses (for example, 9 times, which is equal to 45 mg), there are no clinically significant signs. However, drowsiness may develop.

As a treatment, it is required to wash the stomach and take activated charcoal. It should also be noted that desloratadine is not excreted by hemodialysis.

Compatibility with other drugs

The interaction of the drug "Dizal" with other medications has not been identified (including with "Erythromycin" and "Ketoconazole"). It should also be said that desloratadine does not enhance the effect of ethanol on the central nervous system.

Allergies (urticaria, itching, rash, etc.) in people with severe renal impairment should be treated with extreme caution.

According to studies, the drug "Dizal" does not affect the patient's driving. But it should be taken into account that it is extremely rare for some people to develop drowsiness. In this case, special care must be taken when driving a car and when working with complex mechanisms.

Cost and analogues of the drug

Unlike other antiallergic drugs, the price of the drug "Dizal" is not very high. You can buy this medication for 200-350 rubles (10 and 30 tablets, respectively).

As for the analogues of the drug in question, there are a great many of them. We list them: Lordestin, Blogir-3, Erius, Desloratadine, Elisey, Desloratadine-Teva, Ezlor, Desloratadine Canon, Nalorius, Desloratadine-Pharmaplant.

Reviews of the antiallergic drug

The drug "Dizal" is an inexpensive anti-allergy drug, which leaves a lot of both negative and positive reviews. Most patients report that this medication does the job well. It quickly and effectively eliminates all the symptoms of an allergic reaction, significantly improving the patient's well-being.

People who have taken Dizal tablets testify that it is very convenient to use them. Unlike other drugs, the medication in question is enough to take once a day and you can forget about allergies.

There are also negative reviews about this medication. Many patients cannot take it because they immediately develop allergic reactions. Doctors prescribe safer medicines for such patients.

xn——olcaanbdygasfn1at6g.xn—p1acf
To favorites To favorites To favorites

Desal instructions for use

• Manufacturer
• Country of origin
• Product group
• Description
• Release form
• Description of the dosage form
• pharmachologic effect
• Pharmacokinetics
• Special conditions
• Compound
• Desal indications for use
• Contraindications
• Side effects
• drug interaction
• Storage conditions

Manufacturer

FIDIFARM d.o.o. Actavis Ltd Balkanpharma – Troyan AD Specifar S.A.

Country of origin

Bulgaria Greece Malta

Product group

Antiallergic drugs

Histamine H1 receptor blocker. Antiallergic drug

Release form

• 10 - blisters (1) - packs of cardboard 10 - blisters (3) - packs of cardboard solution for oral administration 0.5 mg / ml: 100 ml,

Description of the dosage form

• Oral solution clear, colorless, free from foreign particles Film-coated tablets

pharmachologic effect

Long-acting antihistamine drug, blocker of peripheral histamine H1 receptors. Desloratadine is the primary active metabolite of loratadine. Inhibits the cascade of allergic inflammation reactions, incl. release of pro-inflammatory cytokines, including interleukins IL-4, IL-6, IL-8, IL-13, release of pro-inflammatory chemokines, production of superoxide anions by activated polymorphonuclear neutrophils, adhesion and chemotaxis of eosinophils, release of adhesion molecules such as P-selectin, IgE- mediated release of histamine, prostaglandin D2 and leukotriene C4. Thus, it prevents the development and facilitates the course of allergic reactions, has antipruritic and antiexudative effects, reduces capillary permeability, prevents the development of tissue edema, smooth muscle spasm. The drug has no effect on the central nervous system, has practically no sedative effect (does not cause drowsiness) and does not affect the speed of psychomotor reactions when taken in recommended doses. Does not cause prolongation of the QT interval on the ECG. The action of desloratadine begins within 30 minutes after ingestion and lasts for 24 hours.

Pharmacokinetics

Absorption After oral administration, desloratadine is well absorbed from the gastrointestinal tract. It is determined in the blood plasma after 30 minutes, and Cmax is reached after approximately 3 hours. There were no clinically significant changes in the concentration of desloratadine in the blood plasma with repeated administration of ketoconazole and erythromycin. The bioavailability of desloratadine is dose-proportional with doses ranging from 5 mg to 20 mg. Distribution Plasma protein binding is 83-87%. When used in adults and adolescents for 14 days at a dose of 5 mg to 20 mg 1 time / day, there are no signs of clinically significant cumulation of desloratadine. The degree of cumulation of desloratadine is consistent with the T1 / 2 value and the frequency of its use 1 time / day. The values ​​​​of AUC and Cmax in children were similar to those in adults who received 5 mg of desloratadine. Simultaneous ingestion of food or grapefruit juice does not affect the distribution of desloratadine (when taken at a dose of 7.5 mg 1 time / day). Does not penetrate the BBB. Metabolism The enzymes responsible for the metabolism of desloratadine are not yet known, so interactions with certain drugs cannot be completely ruled out. It is not an inhibitor of CYP3A4 and CYP2D6 and is not a substrate or inhibitor of P-glycoprotein. Intensively metabolized in the liver by hydroxylation to form 3-OH-desloratadine, which is then glucuronized. Withdrawal The terminal phase T1 / 2 is about 27 hours. Desloratadine is excreted from the body in the form of a glucuronide compound and in a small amount unchanged (with urine - less than 2% and through the intestines - less than 7%).

Special conditions

In case of severe renal impairment, Desal should be taken with caution. Influence on the ability to drive vehicles and mechanisms In studies, no effect of desloratadine on driving was noted. However, it should be borne in mind that very rarely, some patients may develop drowsiness, in this case, care should be taken when driving vehicles and when working with mechanisms.

Compound

• 1 ml desloratadine 0.5 mg desloratadine 5 mg Excipients: microcrystalline cellulose - 55 mg, pregelatinized corn starch - 15 mg, mannitol - 22 mg, talc - 2.5 mg, magnesium stearate - 0.5 mg. The composition of the film shell: opadra blue 03F20404 (hypromellose 6cP - 1.9 mg, titanium dioxide (E171) - 0.61 mg, macrogol 6000 - 0.34 mg, dye indigo carmine aluminum lacquer (E132) - 0.14 mg) - about 3 mg.

Desal indications for use

• To relieve or eliminate the symptoms of: - allergic rhinitis (sneezing, nasal congestion, rhinorrhea, itchy nose, itchy palate, itchy and red eyes, watery eyes); - Urticaria (skin itch, rash).

Desal contraindications

• - pregnancy; - the period of breastfeeding; - children's age up to 12 years (efficacy and safety have not been established); - hypersensitivity to the active or any excipient of the drug. The drug should be used with caution in severe renal failure.

Desal side effects

• More often than others, the following adverse reactions are noted: increased fatigue (1.2%), dryness of the oral mucosa (0.8%), headache (0.6%). When using the drug in adults and adolescents at the recommended dose of 5 mg / day, the incidence of drowsiness is not higher than when using placebo. During post-marketing surveillance, the following adverse reactions were very rarely noted. Mental disorders: hallucinations. From the side of the central nervous system: dizziness, drowsiness, insomnia, psychomotor hyperactivity. From the side of the cardiovascular system: tachycardia, palpitations. From the digestive system: abdominal pain, nausea, vomiting, dyspepsia, diarrhea. From the side of the liver and biliary tract: increased activity of liver enzymes, increased concentration of bilirubin, hepatitis. From the musculoskeletal system: myalgia. Allergic reactions: anaphylaxis, angioedema, itching, rash, urticaria

drug interaction

Clinically significant interactions with other drugs have not been identified (including with ketoconazole and erythromycin). Desloratadine does not enhance the effect of ethanol on the central nervous system.

Storage conditions

• store at room temperature 15-25 degrees
• keep away from children

apteka.ru

Disal is a pharmacological agent that is used in the fight against allergies. This drug blocks histamine H1 receptors, which have a long-term effect.

The drug is aimed at blocking allergies and all its side effects, namely: itching, burning, redness, blisters.

In addition to the blocking function, it prevents or eliminates allergic reactions. Disal removes swelling, muscle spasms, reducing capillary permeability.

This drug is a metabolite of loratadine.

Desal can be found in any pharmacy in the form of tablets and syrup.

Description of the form and composition of the drug Dizal

The active ingredient in Disal is desloratadine. This element is an active blocker of an allergic reaction and an assistant in reducing puffiness. In addition to the main component, the composition contains: magnesium, talc, corn starch in a gelled form.

Disal can be found in any pharmacy.

It is sold in several versions:

• Tablets. This form is for adults. Tablets have a rich blue color, round shape and bulges on each side. In a pharmacy, it is delivered in a packaged form, packed in a cardboard box. Inside the package is an introductory instruction that says how to take the drug Dizal.
• Suspension (syrup). This type of Dizal is for children. The active substance in suspension is the same as in tablets. But in addition to the listed components, Disal syrup contains substances: sucralose, fruit flavor, citric acid, sodium citrate, sorbitol. This gives the syrup a liquid state as well as flavor. The syrup is supplied in dark bottles, which are packed in a cardboard box. The kit includes instructions for use and a special medicine spoon. The suspension has a pronounced fruity taste and smell, a transparent color without any precipitation.

By what principle does the drug Dizal work?

Disal is an antihistamine drug that is aimed at long-term action. It is related to histamine blockers in the human body and suppresses the allergic reaction.

The active substance desloratadine is a metabolite of loratadine, which is also aimed at the release, activation of chemokine and cytokine. This anti-allergic drug helps to relieve allergic symptoms, is a preventive measure for an allergic person, and suppresses burning and itching in inflamed areas.

Disal reduces puffiness and removes muscle spasms, which helps eliminate swelling caused by allergies. The study of the drug, as well as multiple evaluations and reviews of patients prove that the drug does not cause a feeling of drowsiness and fatigue. After using the drug, its effect on the body begins to actively spread in half an hour.

This effect lasts one day, about 24 - 27 hours. A large concentration of the substance is observed three hours after its application. All active ingredients in tablets are absorbed by the body by 86% - 88%, which is an excellent indicator.

The active substance contained in the preparation is absorbed and processed by the liver. The remains of undigested components are excreted by the kidneys through the urine.

The use of the antiallergic drug Dizal

Disal is sold in tablets or suspension, both of which are taken by mouth. Dizal can be taken at any time, it does not depend on the time of the meal.

For children under 12 years of age, the doctor prescribes a suspension that must be taken in the following dosage:

1. 2.5 ml of the substance once a day for children from one year to five years.
2. Children whose age is from five to eleven years old can take the drug 5 ml once a day.
3. If adolescents from 12 years of age and adults take syrup, then they need a dose of Dizal in 10 ml once a day.
4. Dizal tablets can be used from 12 years of age and older. The dosage of the drug for allergies in tablets is 5 mg 1 time per day.

The drug in the form of tablets can be taken by children over 12 years of age.

When is Dizal appointed?

Doctors prescribe the drug to people susceptible to allergens. The drug helps to eliminate the allergic reaction and relieves the symptoms of its effects.

The appointment of Dizal is required in the following cases:

1. Urticaria with acute itching and burning of the skin, caused by redness and inflammation.
2. Allergic edema of the palate.
3. Allergic edema on the face.
4. Itching, burning in the eyes and redness.
5. Itching and discharge from the nose.
6. Sneezing.
7. Inflammation of mucous membranes.
8. Excessive tearing caused by an allergen.

1 tablet is able to suppress an allergic reaction for 24 - 27 hours

Contraindications to the use of the antiallergic drug Dizal

The drug has side effects when used. Their occurrence is purely individual and depends on the characteristics of the organism.

To reduce the likelihood of a negative effect of a drug on the body, it is worth studying contraindications:

• Based on the reviews of people who used the drug and from the studies of doctors, this drug is not advised to be taken by pregnant women. In addition, during breastfeeding, you should refrain from using Disal.
• Children under 12 years of age should not be given the drug in tablets, only in suspension.
• The drug is not prescribed by a doctor if the patient has intolerance and hypersensitivity to the active substance, as well as to other components.
• Do not give Dizal to children under one year old, their body is very weak, it cannot absorb substances.

Desal can be prescribed by a doctor after consultation

Side effects that occur when taking Dizal

When using the drug, side effects occur.

Based on laboratory studies and reviews of people who used Dizal, negative reactions of the body to the active substance were derived:

• The body of children who are from two to eleven years old can perceive desloratadine, as well as placebo.
• In children under two years of age who were given the drug, side effects were observed: insomnia, abdominal pain and loose stools, body temperature could rise.
• Adolescents (from 12 years old) and older people found negative reactions to the active substance in the drug, deterioration in activity and ability to work, frequent headaches, lack of salivation and thirst.
• A small number of people experienced increased drowsiness and fatigue.
• Isolated cases of mental disorders, expressed in the hallucinogenic effect.
• Violation of the central nervous system: headache, convulsive syndromes, lack of sleep, hyperactive state, restlessness at work, inattention.
• Heart problems: tachycardia, tingling in the region of the heart and palpitations.
• There was a disorder of the digestive system, especially diarrhea and vomiting.
• The drug causes an allergic reaction in the form of swelling, rash, redness, shortness of breath, itching and burning.

An overdose of 45 mg does not lead to death, as well as to serious reactions of the body. It is better to do a gastric lavage and use activated charcoal to improve well-being.

Nausea can be a side effect

Special considerations when using Disal

The safe effect of the drug on the child's body has not been established. Children under the age of one year should not be given Dizal. In children under two years of age, the use of the drug may cause an allergic reaction and swelling.

Before giving the drug to young children, it is necessary to consult a doctor, pass the necessary tests that reveal tolerance, side effects on a fragile body. A detailed examination of the respiratory tract and analysis of the skin for the reaction of the active substance are carried out.

About 6% of children and adolescents tolerate Dizal with difficulty. Their metabolism slows down and their immune system worsens. The substance desloratadine is poorly absorbed and its residues are poorly excreted from the patient's body.

In case of violation of the kidneys, it is worth taking the drug with great care or abandoning it, this body is responsible for removing undigested substances from the body that are in Disal.

Studies have not been conducted on people who drive a car or occupy a work position where increased concentration is needed.

Based on this, it must be remembered that one of the adverse reactions of the body is drowsiness, loss of concentration and increased fatigue. People undergoing treatment may have problems with technical work and driving.

Desal helps to cope with all manifestations of allergies

Parallel reception of Dizal with medicines

Negative effects on the body when taking other medications have not been identified. Also, studies have not confirmed that the use of alcoholic beverages and the use of Dizal cause problems with the central nervous system.

telemedicine.one

Faced with unpleasant manifestations, any person begins to look for a remedy that can relieve the symptoms associated with the disease. In pharmacies, you can find the drug Desal, which has proven itself on the positive side in the past few years.

When the drug can be used, the required dosage and other features of the antihistamine are discussed in this article.

Release form

Desal is an effective drug, using which you can successfully get rid of various manifestations of allergies. The tool is not only able to eliminate existing symptoms of the disease, but also prevent the emergence of new ones.

Desal is available in the form of tablets and solution.

Tablets in a dosage of 5 mg. Each is covered with a special film shell of bright blue color, acquired by adding a special coloring component.

The outer part contains:

• titanium dioxide;
• dyes - indigo carmine and opadra blue;
• macrogol.

The effect of taking is achieved due to the content of the active substance desloratadine. Its amount is 5 mg. In addition, the tablets contain:

• cellulose microcrystalline;
• magnesium stearate;
• corn starch in pregelatinized form;
• talc;
• mannitol.

The shape of the tablet is biconvex, the letters “LT” are applied to one of the surfaces.

A standard carton pack contains 10, 20 or 30 dragees packed in special blisters of 10 pieces each.

The liquid form, erroneously called syrup in some cases, is convenient for relieving the symptoms of allergic reactions in children. It contains 0.5 mg per 1 ml of the main substance that has an antiallergic effect - desloratadine.

The composition of the medicine taken orally also includes additional components:

• sorbitol;
• flavoring with the smell and taste of "Tutti-frutti";
• hypromellose;
• editat disodium;
• citric acid monohydrate;
• sodium citrate dihydrate;
• sucralose;
• propylene glycol.

The solution is colorless, has no foreign inclusions and solid particles. The manufacturer produces the drug in various dosages, including both small bottles of 50, 60 and 100 and 120 ml, intended for short-term use, and rather large containers containing 150 or 300 mg of the drug.

For dosage accuracy, a syringe or a measuring spoon with special divisions is inserted into the cardboard pack.

pharmachologic effect

The tool has a long-term effect and eliminates the unpleasant symptoms of the disease by blocking histamine H1 receptors. The effect is achieved through the action of the active ingredient - desloratadine, which is the primary metabolite of one of the most effective antiallergic substances - loratadine.

The pharmacological action of Desal is:

• decrease in capillary permeability;
• reduction of tissue edema and prevention of its development;
• prevention of spasms to which smooth muscle tissue is exposed;
• antipruritic effect;
• antiexudative action.

The sedative effect when taking the drug was not revealed, and there is also no effect on psychomotor activity - its speed remains unchanged.

Pharmacokinetics

The main component, getting into the digestive tract, is absorbed through its lumen. In plasma, the substance appears already half an hour after ingestion, and the maximum concentration is observed after 3 hours. Distribution is not affected by grapefruit juice, and even food intake.

The degree of connection with plasma proteins is estimated at 83-87%. The blood-brain barrier for drug substances remains impenetrable.

Metabolism of substances is observed in the liver. At the same time, only a small proportion of glucuronide components is excreted from the body - about 2% through the kidneys, and about 7% - along with feces.

Mechanism of action

The impact is carried out by inhibiting the reactions of the body caused by exposure to allergens. There is a release:

• chemokines that effectively cope with inflammation;
• cytocones, including interleukins IL-4,8,13;
• p-selectin;
• leukotriene C4, histamine and prostaglandin D2.

These reactions, together with adhesion and chemotaxis of eosinophils, contribute to the suppression of allergy and its symptoms, and also prevents the development of the latter.

Indications

Desal, having a pronounced antihistamine effect, is used when the following symptoms are detected:

• skin rashes accompanied by itching;
• allergic rhinitis, manifested in the form of congestion and itching of the mucous membrane of the nasal cavity, sneezing, itching of the palatal zone, redness of the eyes and tearing;

When applied, there is a significant relief of the patient's condition and a decrease in the intensity of manifestations of symptoms accompanying allergies.

Contraindications

It is forbidden to take the drug in the form of tablets in the following cases:

• breastfeeding period;
• during pregnancy;
• sensitivity or intolerance to individual components that make up the tablets;
• Age Limit: Not intended for young children (under 12).

When diagnosing renal failure or other pathologies of these organs, it should be used with caution. If the condition worsens, stop taking it and consult a doctor.

Contraindications to the use of the solution are similar to those of the tablets. However, there are also significant differences:

• it is allowed to apply to children older than 1 year;
• it is forbidden to take if there are problems with the absorption of glucose or galactose;
• insufficient amount of sucrose or isomaltose in the body, most often due to a genetic predisposition. This contraindication appears due to the inclusion of sorbitol in the composition.

Instructions for use

The drug in tablet form is intended for oral administration by adults and

children over 12 years of age. Dependence on food intake has not been established.

The solution is intended for both children and adults, however, its use in pediatric practice is most often registered.

The remedy in any form is taken once a day. For tablets, 1 dose is 5 mg, which is equal to 1 tablet. The application of the solution is carried out according to the following scheme:

• patients older than 12 years are shown to take 10 ml of liquid;
• patients from 6 to 11 are given a dose of 5 ml once;
• from 1.5 to 5 years, 2.5 ml is taken.

Since the use of Desal is not associated with food intake, the remedy can be consumed in the morning, afternoon or evening.

A significant excess of the dose leads to the appearance or increase of side effects. Overdose also leads to the development of pathological disorders in the liver.

If you take a large amount of medication, you should stop treatment and contact a medical institution. Usually, complex therapy is applied to the patient, which consists in washing the stomach and taking specialized agents - enterosorbents.

In especially severe cases, symptomatic treatment is indicated.

Adverse reactions

It has an impact on various systems of vital activity, both with long-term therapy and when the dose is exceeded. The following side effects have been registered:

• feverish condition (especially in young children);
• dry mouth;
• tachycardia and rapid heartbeat;
• muscle pain;
• migraine;
• insomnia;
• irritability;
• diarrhea, vomiting and nausea;
• pain in the abdomen.

Possible aggravation of the course of allergic reactions, manifested in the form of itchy skin rashes, in severe cases, the development of Quincke's edema and the onset of anaphylactic shock are recorded.

drug interaction

Negative effects when interacting with other medicines, including Erythromycin and Ketoconazole, have not been identified. However, when taking clinically significant medications, you should consult with your doctor before taking Dezol.

The tool does not aggravate the effect of ethyl alcohol on the body. Data on the increase in the effect of alcohol with the use of antihistamines have not been identified.

special instructions

Treatment of young children should be started only after special tests and laboratory tests have been carried out to verify the allergic origin of rhinitis. Desal will not cure an infectious disease accompanied by foci of inflammation.

Large doses or excessive individual susceptibility to the components can cause increased drowsiness. When diagnosing this side effect, driving motor vehicles and other complex mechanisms should be avoided.

Patient opinions

The effectiveness of Desal is convinced by the reviews left by patients:

When using the drug, I found that the allergy to wool no longer bothers me. There was not enough other anti-allergic drugs for a long time, which made it especially difficult to visit friends who have animals. But Desal's actions are enough to last a day. I use it all the time, since contacts with it are almost impossible to avoid.

Irina Kudryavinskaya, 35 years old

Periodically, the face and body are covered with strange rashes, similar to dermatitis. The view is just awful. Previously, it was saved by yarrow-based compresses, but lotions acted very weakly. But Desal got rid of the rash with almost one pill. So the medicine definitely suits me.

Alina Petrova, 28 years old

Great for seasonal exacerbations. Runny nose and tearing ceased to disturb at all.