Phlebodia composition instructions for use. Phlebodia - instructions for use. Contraindications for use

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Instructions for use of the drug Phlebodia 600

Therapeutic class and pharmacological group of the drug Phlebodia 600

medical drug Phlebodia 600 contains 600 mg of an active ingredient called diosmin (Diosmin).

Diosmin belongs to the therapeutic class of angioprotectors - drugs that strengthen and protect blood vessels.

This medicinal substance belongs to the pharmacological group of flavonoids - substances that increase the strength of capillary walls and improve metabolic processes in the microcirculatory bed.

Pharmacokinetics of Phlebodia 600 (metabolism of the active substance in the body)

The active substance of Phlebodia 600 tablets is quickly absorbed in the gastrointestinal tract, and already two hours after ingestion, a sufficiently high concentration is created in the blood plasma (the maximum concentration is reached five hours after ingestion).

Having entered the blood plasma, the drug is redistributed in the tissues of the body. The highest concentration is created in the inferior vena cava and external veins of the lower extremities. To a lesser extent, diosmin accumulates in the liver, kidneys, and lungs. In other organs and tissues, its concentration is extremely low.

This selective accumulation of the active substance Phlebodia 600 reaches its maximum 9 hours after administration. Traces of the drug in the walls of the veins can be detected 96 hours after consumption. The duration of complete elimination is explained by the enterohepatic circulation of diosmin and its metabolites (molecules of the substance are excreted in the bile, and then reabsorbed in the intestine and enter the blood plasma).

Diosmin and its metabolites are excreted mainly by the kidneys (about 80%), a smaller part is excreted through the intestines.

The mechanism of action of the drug Phlebodia 600

The effect of Phlebodia 600 on the human body is due to the pharmacological properties of diosmin, which:

increases the tone of the veins and reduces the effects of venous stasis;
strengthens the walls of capillaries, reduces their permeability and improves metabolic processes in the microvasculature;
due to a pronounced anti-inflammatory effect, relieves pain and reduces tissue swelling;
improves lymphatic drainage, which also leads to a reduction in edema.

The main indications for the use of Flebodia 600

The anti-inflammatory properties of the drug, as well as its angioprotective effect, are widely used in the treatment of acute hemorrhoids, as well as exacerbations of its chronic form.

The ability of Phlebodia 600 to reduce the effects of venous congestion, reduce tissue swelling and improve metabolic processes in the microcirculatory bed, are used in the treatment of chronic venous insufficiency.

In addition, the drug Phlebodia 600 is used in the postoperative period to reduce the manifestations of orthostatic hypotension (a sharp decrease in systemic pressure when moving to a vertical position).

There is evidence of the successful use of the drug for the prevention of bleeding after surgery for phlebectomy (removal of veins). Some researchers believe that Phlebodia 600 may also prevent hemorrhagic complications when using an intrauterine device.

Side effects and contraindications to the appointment of Flebodia 600 tablets

Instructions for use of the drug states that Flebodia 600 tablets are not prescribed to children under 18 years of age and women during lactation (there is no data on the possibility of penetration of the drug into milk).

The drug is also contraindicated in case of hypersensitivity to its components, which is quite rare.

Among the side effects of Phlebodia 600, dyspepsia is the most common (occurs in every hundredth patient) - most often it is diarrhea, sometimes nausea and vomiting.

Much less common is an undesirable effect on the central nervous system, manifested by headache.

Treatment of hemorrhoids should be comprehensive. Taking the drug Flebodia 600 or its analogues, you must adhere to a special diet (exclude spicy foods, prevent constipation). In addition, local treatment is prescribed taking into account the predominant symptom (bleeding, pain, thrombosis, inflammation).

The use of Phlebodia 600 in the treatment of chronic venous
lower limb insufficiency

Varicose veins and the consequences of thrombophlebitis as the main causes
chronic venous insufficiency

Chronic venous insufficiency (CVI) is a group of diseases characterized by a violation of the outflow of venous blood from the lower extremities due to changes in the lumen of the vessels and deformation of the valve apparatus of the veins.

The main manifestations of CVI are swelling, pain, trophic disorders (up to the formation of trophic ulcers). Chronic venous insufficiency eventually leads to impaired lymph circulation, and transforms into chronic lymphovenous insufficiency.

The main nosological forms of chronic venous insufficiency of the lower extremities are varicose veins and post-thrombophlebic syndrome.

According to WHO, about 20-25% of the world's population suffer from varicose veins of the lower extremities, which is manifested by their saccular deformity, tortuosity of the channel and valve insufficiency. Women get sick more often, which is facilitated by changes in the body associated with the menstrual cycle, pregnancy and childbirth.

Patients complain of a cosmetic defect of varying severity - from individual spider veins to large nodes and tortuous venous trunks, which are detected in a vertical position. Also, patients complain of fatigue and swelling, increasing in the evening and disappearing in the morning after a night's rest. With the progression of the disease, cramps appear in the calf muscles, paresthesia. It is possible to develop complications such as thrombophlebitis (manifested by a painful seal around the affected venous trunk) and bleeding from a varicose vein.

Postthrombophlebic syndrome is much less common (1.5 - 5% of the world's population). It occurs as a complication of thrombosis of the internal veins of the lower extremities, and is manifested by secondary varicose veins, edema, trophic disorders of the skin and subcutaneous tissue of the leg.

Theory and practice of using Phlebodia 600 in chronic venous insufficiency

The main methods of treatment of the initial stages of chronic venous insufficiency of the lower extremities are elastic compression (creation of an artificial support frame for pathologically altered veins) and pharmacotherapy.

The main goals of conservative treatment:
1. Slowing down the progression of the disease.
2. Prevention of complications.
3. Improving the quality of life (reduction of edema, removal of pain, etc.).

Medicines for local use (ointments, etc.) play an auxiliary role in the treatment of chronic venous insufficiency. Of paramount importance are systemic drugs (including Phlebodia 600 and its analogues), which increase the tone of the veins, relieve pain and swelling, improve metabolic processes in the microcirculatory bed, preventing the occurrence of trophic disorders and, finally, improve lymphatic drainage, preventing the occurrence of lymphovenous insufficiency.

It should be noted that the clinical effect of this group of drugs has been proven only partially (in relation to the removal of edema). But when a strong-willed decision was made in Italy to cancel subsidies for this group of drugs, which led to a sharp decrease in their consumption, there was a sharp increase in cases of hospitalization of patients due to decompensated forms of chronic venous insufficiency.

Therefore, experts recommend using Phlebodia 600 in combination with other therapeutic measures. Among them: wearing elastic stockings, normalizing body weight, walking, normalizing the regime of work and rest. You should also follow all medical recommendations (it is necessary to avoid prolonged exposure to the sun, refrain from

Phlebodia 600 is a drug that helps fight varicose veins in the legs. Phlebodia belongs to the group of angioprotective drugs. This means that the action of this drug is aimed at protecting and restoring already weakened veins that have lost their tone.

The venotonic effect of the drug is caused by its constituent - diosmin. This is an active substance that has a direct effect on the human body as a whole.

The drug Phlebodia 600 has many analogues in its main component, but they all differ in many additional (auxiliary) substances. The manufacturer of this drug is the French laboratory INNOTHERA CHOUZY.

Release form and composition

Phlebodia 600 is available in tablet form. Tablets are convex, round, 15 pieces in a blister. Usually a pack contains 1 or 2 blisters, that is, a package contains 15 or 30 tablets.

The composition includes the active substance diosmin. The dosage of diosmin is 600 mg. Among the excipients, microcrystalline cellulose at a dosage of 910 mg, stearic acid - 50.05 mg, colloidal silicon dioxide - 3.5 mg and talc - 10.24 mg can be distinguished.

Indications for use

Instructions for use shows this drug:

with trophic disorders of the lower extremities;
with venous insufficiency;
With thrombophlebitis
with heaviness in the legs;
with lymphatic insufficiency;
with superpermeability of capillaries;
with exacerbation of hemorrhoids.
When spider veins appear

Contraindications

Tablets from varicose veins Phlebodia are contraindicated in patients prone to allergies. It is also undesirable to take this drug to patients with chronic kidney and liver diseases.

Side effects

Side effects include the appearance of allergies, stomach upset, and headache. Often this drug does not cause negative effects, so it can be taken during pregnancy, but only after consulting a doctor.

How to drink medicine?

Treatment of varicose veins is effective if the drug is taken correctly. Very often, patients are interested in:

“How often can I take this drug?”, Or “How to take it: before meals or after?”. Many people are interested in the answer, so you can read this information further.

The medicine must be taken as a tablet before meals, preferably in the morning. The course of treatment is a month, in some cases - two months. It depends primarily on the extent to which the veins in the legs are affected and the degree of the disease.

Phlebodia with varicose veins of the small pelvis helps to increase the tone of the veins, as well as the microcirculation of blood in them, has an anti-inflammatory effect, helps to reduce blood stasis in the veins. However, such a cure for varicose veins of the legs requires compliance with special rules during treatment. First of all, you should:

Avoid prolonged sun exposure.
Monitor your weight and try to reduce it as much as possible (in case of obesity).
To walk outside.
Combine treatments (take pills, ointments and wear special clothing).

It is not easy to follow such rules, especially at first, but this will ensure effective and quick recovery and help avoid the negative consequences of a disease such as varicose veins.

The method of using the drug for various diseases

Depending on the disease and its degree, dosages vary.

Phlebodia with hemorrhoids.

During hemorrhoids, the drug is allowed to take 2 or 3 tablets per day. Reception to carry out during meals. The course of treatment is 7 days.

With hemorrhoids, this drug can reduce the occurrence of hemorrhoidal veins, helps to neutralize inflammation, pain and discomfort.

Phlebodia with varicose veins.

This drug is indicated for use in combination with other venotonic drugs. Compliance with such a treatment regimen allows you to:

slow down the further progression of the disease;
prevent possible complications;
relieve pain and reduce swelling of the legs.

Phlebodia should be taken once a day before breakfast in the morning. The course of treatment is from 2 to 6 months, depending on the degree of the disease.

Phlebodia during pregnancy.

In pregnancy, this drug is indicated for the treatment of chronic lymphovenous insufficiency in the last two trimesters of pregnancy (second and third trimesters).

It should be noted that when taking Phlebodia, it is necessary to stop taking 14 days before the date of the expected birth. Overdose of drugs during pregnancy has not been identified. Feedback from patients during this period is positive.

Instructions from the drug packaging

How much does this drug cost?

The price of a drug such as Phlebodia directly depends on the region of purchase and on the number of tablets.

For example, when buying "Flebodia 600" No. 15, you will need to pay from 395 to 695 rubles.

And when buying "Flebodia 600" No. 30, the cost will be approximately from 685 to 1742 rubles. for packing. You can buy this drug at any pharmacy or pharmacy.

Phlebodia and alcohol

The drug is compatible with alcohol. This means that alcohol does not affect the effect of the drug. However, this should not be abused, since taking this drug is often combined with other venotonics, and those, in turn, are not always compatible with alcohol.

Phlebodia when taking ok (oral contraceptives)

Quite often, many women are interested in the question of whether it is possible to take oral contraceptives in combination with Phlebodia 600 venotonic. The answer is yes, you can. This drug is approved for use in combination with contraceptives, but a doctor's consultation is necessary before taking.

Analogues

Among the analogues of Phlebodia 600, the following drugs can be distinguished: Vasoket 600 and Diovenor 600. These are generic drugs, that is, they are absolute analogues of Phlebodia 600.

The drug Diosmin is the Russian analogue of Phlebodia. It contains 500 mg of active ingredient.

This drug also differs in the number of excipients, as well as popularity among consumers.

Detralex

The drug Detralex is similar to Phlebodia, but it contains 450 mg of diosmin and 50 mg of hesperidin.

The difference lies in the fact that Detralex is excreted through the gastrointestinal tract, which makes it possible for people with kidney and liver disease to take it.

The drug Venolek contains 500 mg of diosmin. Its difference from Phlebodia is that it causes many side effects.

Quite often, patients complain of rashes, itching, headaches and frequent dizziness.

Some people experience a decrease in blood pressure, vomiting, nausea. Venolek is a cheap analogue of Phlebodia. Excreted by the kidneys and intestines.

There are also analogues that have the same effect as Phlebodia, but they differ in composition, cost and form of release. These include:

Venarus.
Troxevasin gel.
Venoruton.
Solcoseryl gel.
Flexital.
Thromboass.

Phlebodia 600 (active ingredient - diosmin) - the original venoprotector from the French pharmaceutical company "Laboratory Innotec International". The drug has a venotonic effect (increases their tone in a dose-dependent manner, reduces extensibility, prevents venous congestion), accelerates the outflow of lymph, thereby ensuring the implementation of the drainage function (tones and increases the frequency of contraction of the muscular membrane of the lymphatic capillaries, increases their functional activity, reduces pressure in the lymphatic channel) , stimulates blood flow in the capillary bed (dose-dependently increases vascular resistance, reduces the permeability of capillary walls), prevents leukocytes from sticking to the walls of the veins and inhibits their movement into paravenous tissues, improves the diffusion of molecular oxygen and promotes oxygenation of the skin tissue. In addition to this, Phlebodia 600 exhibits an anti-inflammatory effect, enhances the vasoconstrictor effect of catecholamines, blocks the reproduction of free radicals, the synthesis of inflammatory mediators and allergic reactions of prostaglandins and thromboxane. The drug is rapidly absorbed in the gastrointestinal tract and enters the systemic circulation in therapeutically significant concentrations within 2 hours after administration. The maximum concentration of the active substance in the blood plasma is observed 5 hours after ingestion. The drug is evenly distributed and accumulated in the thickness of the walls of the vena cava and superficial veins of the legs, and, to a lesser extent, in the internal organs (kidneys, liver, lungs). The accumulation of Phlebodia 600 and its metabolites in the vessels of the venous bed reaches its highest rate at 9 hours after oral administration and persists for 4 days. The main part of the drug is excreted by the kidneys, the remaining amount - through the intestines.

Phlebodia 600 is available in the form of tablets. Before starting a medication course, you should consult with a specialist. In case of varicose veins with the localization of the pathological process in the veins of the lower extremities, as well as with swelling, pain and convulsions, which are the result of chronic lymphovenous insufficiency, the drug is taken on an empty stomach, 1 tablet per day.

The duration of treatment is usually 2 months. In acute hemorrhoids (or exacerbation of chronic) Phlebodia 600 take 2-3 tablets per day with meals for 1 week. If, for some reason, the drug is missed, it is not necessary to compensate for the missed doses by taking additional doses (pharmacotherapy continues as usual at the same doses). Treatment of acute hemorrhoids should be complex (in other words, not based on one drug). If the clinical effect is not sufficiently pronounced, the patient should be referred for additional examination and adjustments to the treatment should be made.

The effectiveness of Phlebodia 600 has been demonstrated in a number of clinical studies, the largest of which involved about 7,000 patients. In this study, participants took 1 tablet of the drug per day (in acute cases - 2 tablets). Patients were subjected to a medical examination before and at the end of the first month of treatment. In general, the observation lasted for 2 months. Study participants were instructed to forego other phlebotonics and to avoid significant adjustments to their lifestyle and routine habits (including food preferences and physical activity levels). The results obtained at the end of the clinical trial made it possible to state the high therapeutic efficacy of Phlebodia 600 and to determine the optimal ways of using the drug. The drug showed itself from the best side, surpassing its competitors in the pharmacological "niche". So, when using Phlebodia 600, more than 80% of positive outcomes were obtained, while for other venotonics this figure did not exceed 40%. The dependence of the effectiveness of therapy on its duration was noted. So, the good results obtained by the end of the first month of the drug course, provided that the drug is continued, are transformed into excellent ones.

Pharmacology

The drug has a phlebotonizing effect (reduces vein extensibility, increases vein tone (dose-dependent effect), reduces venous congestion), improves lymphatic drainage (increases the tone and frequency of contraction of lymphatic capillaries, increases their functional density, reduces lymphatic pressure), improves microcirculation (increases the resistance of capillaries (dose-dependent effect), reduces their permeability), reduces the adhesion of leukocytes to the venous wall and their migration to paravenous tissues, improves oxygen diffusion and perfusion in the skin tissue, and has an anti-inflammatory effect. Enhances the vasoconstrictive action of adrenaline, norepinephrine, blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.

Pharmacokinetics

Rapidly absorbed from the gastrointestinal tract, found in plasma 2 hours after ingestion. C max in blood plasma is achieved 5 hours after ingestion. It is evenly distributed and accumulated in all layers of the wall of the vena cava and saphenous veins of the lower extremities, to a lesser extent - in the kidneys, liver and lungs and other tissues.

The selective accumulation of diosmin and / or its metabolites in the venous vessels reaches a maximum by 9 hours after ingestion and persists for 96 hours. Excreted by the kidneys - 79%, intestines - 11%, with bile - 2.4%.

Release form

Pink, film-coated tablets, round, biconvex.

	1 tab.
diosmin in terms of dry matter	600 mg

Excipients: talc - 10.24 mg, colloidal silicon dioxide - 3.5 mg, stearic acid - 50.05 mg, microcrystalline cellulose - up to 910 mg.

The composition of the film shell: Sepifilm ® 002 (hypromellose (E 464) - 9.832 mg, microcrystalline cellulose - 7.866 mg, macrogol 8 stearate type 1 - 1.967 mg); Sepispers ® AP 5523 pink (propylene glycol - traces, hypromellose (E 464) - 0.458 mg, titanium dioxide (E 171) - 4.026 mg, crimson dye [Ponso 4R] (E 124) - 0.401 mg, iron oxide black (E 172) - 0.13 mg, iron oxide red (E 172) - 0.02 mg); Opagloss ® 6000 (Carnauba wax (E 903) - 0.075 mg, beeswax (E 901) - 0.075 mg, shellac (E 904) - 0.15 mg, ethanol 95 ° - traces).

15 pcs. - Al/PVC blisters (1) - cardboard packs.
15 pcs. - Al/PVC blisters (2) - cardboard packs.

Dosage

Before using the drug, you should consult your doctor. The drug is intended for oral administration.

With varicose veins of the lower extremities and chronic lymphovenous insufficiency (edema, pain, convulsions), 1 tab. / day is prescribed. on an empty stomach in the morning. The duration of therapy is usually 2 months.

With exacerbation of hemorrhoids, the drug is prescribed 2-3 tablets / day. during meals for 7 days.

If one or more doses of the drug are missed, it is necessary to continue using the drug as usual and at the usual dose.

Overdose

Overdose symptoms are not described.

Interaction

Clinically significant interaction effects with other drugs have not been described.

Side effects

In rare cases, hypersensitivity to the components of the drug, requiring a break in treatment: on the part of the gastrointestinal tract - dyspeptic disorders (heartburn, nausea, abdominal pain), on the part of the central nervous system - headache.

If any of the side effects listed in the instructions get worse, or if you notice any other side effects not listed in the instructions, tell your doctor.

Application features

Use during pregnancy and lactation

So far, in clinical practice, there have been no reports of any side effects when using the drug in pregnant women. Application during pregnancy in the II and III trimesters is possible only on prescription in cases where the expected benefit to the mother outweighs the potential risk to the fetus.

In experimental studies, no teratogenic effects on the fetus have been identified. During breastfeeding, the drug is not recommended, because. there is no data on the penetration of the drug into breast milk.

Use in children

Contraindicated in children under 18 years of age.

special instructions

Treatment of an acute attack of hemorrhoids is carried out in combination with other drugs, in the absence of a rapid clinical effect, it is necessary to conduct an additional examination and adjust the ongoing therapy.

Influence on the ability to drive vehicles and control mechanisms

There is no evidence of a negative effect of the drug on the ability to drive vehicles and other mechanisms.

Content

Today, pathologies of the vascular system occupy a leading position in terms of mortality. In a situation where there is stagnation of blood circulation, tablets in the Flebodia shell are effective - the instructions for use will help you figure out how to take this medication correctly. Find out what is the advantage of this medicine over other drugs of the same pharmacological group.

Phlebodia tablets

The drug is one of the angioprotectors. The medicine is used to treat diseases of the veins. The active substance of the drug helps to improve blood microcirculation, helps to restore lost vascular tone. According to the instructions for use, Phlebodia tablets are mainly used to treat hemorrhoids and varicose veins of the lower extremities, but are also used for a number of other negative conditions associated with impaired circulation of biological fluids (blood, lymph) in the body.

Compound

Phlebodia is available in tablet form. In this case, one package contains 15 pills. The active ingredient of the medicinal formula is granulated diosmin, a flavone-like pigment, which is obtained from plants of the rue family. One tablet contains 600 mg of pure substance. Among the auxiliary components, the manufacturer in the instructions for use indicates cellulose, stearic acid, red cochineal and other components. You can find out about the mass fraction of each of the mentioned substances in the composition of the angioprotector from the table below:

pharmachologic effect

The therapeutic effect is achieved 60 minutes after taking the medication. At the same time, the therapeutic effect of the angioprotector is maintained for 96 hours. The active components of the drug freely penetrate even the smallest saphenous veins of the lower extremities, lungs, kidneys and selectively accumulate in damaged vascular walls. The therapeutic and restorative effect of the drug Phlebodia is largely determined by the properties of its active substance - diosmin. This flavonoid has the following pharmacological effects:

increases the tone of the veins;
has an anti-inflammatory effect;
fights with excessive permeability of lymphatic capillaries;
prevents the appearance of trophic ulcers;
has a vasoconstrictive effect;
prevents bleeding;
stimulates skin circulation;
stimulates the circulation of biological fluid in the lymphatic vessels.

Indications for use

Tablets from varicose veins Phlebodia effectively act on the venous vessels, thereby preventing their excessive expansion under the influence of high blood pressure. The substance diosmin, as an active component of the drug, improves the microcirculation of biological fluids, eliminates swelling and pain. As part of the complex therapy of venous insufficiency, the drug is used to quickly get rid of the manifestations of acute hemorrhoids or symptoms of varicose veins of the legs. In addition, according to the instructions, the drug is recommended for use in the following vascular problems:

increased fragility of capillaries;
acute uncomplicated hemorrhoids;
lymphovenous insufficiency;
after phlebectomy as a prevention of varicose veins;
violation of venous microcirculation;
after removal of intrauterine devices to prevent bleeding.

How to take Phlebodia

Instructions for use of the drug says that it should be taken orally. The drug is rapidly absorbed from the gastrointestinal tract. The excretion of the active components of the drug occurs mainly by the kidneys. With bile and feces, up to 11% of the incoming diosmin is excreted from the body. The therapy scheme is assigned individually to each patient, taking into account the pathophysiological stage of a particular disease.

In a situation where Phlebodia 600 is used to treat varicose veins or chronic venous insufficiency of the lower extremities, the recommended daily dose of the medication is 1 tablet. The duration of treatment in this case is a month. The presence of trophic ulcers requires a longer course of treatment (about six months). With an exacerbation of the symptoms of hemorrhoids, the instructions for use recommend taking 2-3 tablets of the drug per day for a week.

special instructions

In order to enhance the therapeutic effect of taking the medicine, the manufacturer in the instructions for use recommends that patients adhere to a sparing motor regimen. So, patients with varicose veins and other venous pathologies are highly undesirable to stay in one position for a long time, wear narrow shoes, and lift weights. A good effect after treatment is observed in patients who wear special compression underwear, do gymnastics and adhere to the principles of proper nutrition.

Phlebodia during pregnancy

In the course of large-scale clinical studies, it was proved that the drug does not have a teratogenic (harmful) effect on the body of the mother and fetus. Nevertheless, in order to avoid undesirable consequences (accidental involution), an angioprotector is prescribed only from the second trimester of pregnancy. Reviews of expectant mothers about the use of the drug indicate an extremely positive effect on the body.

drug interaction

The substance diosmin has the ability to enhance the vasoconstrictor effect of other medications. This property of the drug must be taken into account when taking adrenaline and norepinephrine. In addition, Phlebodia 600 should be taken with caution during pregnancy in a situation where the expectant mother uses nasal drops with a vasoconstrictive effect.

Side effects

The reviews of most patients indicate the absence of any negative conditions while taking the angioprotector. With all this, the instruction for the use of the medication reports that in rare cases, dyspeptic symptoms may occur in the form of nausea, pain in the stomach, heartburn. In addition, the drug lowers blood pressure, which is why patients often develop dizziness.

Contraindications

According to the instructions, the drug is not allowed to be used in patients with high sensitivity or resistance to the main components of the drug. In addition, the medicine is contraindicated in children under 18 years of age. Due to the fact that there are no clinical studies on the possibility of diffusion (penetration) of diosmin into breast milk, an angioprotector is not recommended for lactating women.

Terms of sale and storage

The drug is freely available and can be purchased without a prescription. Instructions for use informs that the shelf life of the angioprotector is 2 years. It is recommended to store it at temperatures up to 27 ºС out of the reach of children of the younger age group. The medicine should not be left exposed to reflected or direct sunlight.

Flebodia's analogs

Angioprotectors make up a large group of medications aimed at strengthening the walls of the micro- and macrocirculatory bed. The range of application of Phlebodia analogues is largely similar, which cannot be said about their cost. The significant price difference is due to the use of unique diosmin processing technologies by some pharmaceutical companies. So, among modern drugs created using the most modern equipment, the following effective analogues of Phlebodia can be distinguished:

Vasoket;
Diosmin;
Venarus;
Detralex;
Diovenor.

Phlebodia price

The drug is sold in packs of 15, 30 and 60 tablets. As in the case of any other medicines, it is more profitable for financial reasons to buy several blisters at once. Moreover, it is also expedient from the point of view of compliance with the recommendations of the doctor. In view of these reasons, it is better to purchase medicine with the expectation of the entire course. You can roughly estimate the cost of treatment by reading the capital prices for the drug indicated in the table below.

P N016081/01

Tradename:

PHLEBODIA 600

INN: diosmin (diosmine)

Dosage form: film-coated tablets

Composition per 1 tablet

Active substance:

Diosmin in terms of dry matter .............. 600 mg

Excipients:

talc................................................. ..10.24 mg
colloidal silicon dioxide .....................3.5 mg
stearic acid..............................50.05 mg
microcrystalline cellulose............up to 910 mg

The composition of the film shell:

Sepifilm® 002 (hypromellose (E 464) - 9.832 mg, microcrystalline cellulose - 7.866 mg, macrogol 8 stearate type 1 - 1.967 mg). Sepisprs® AP 5523 pink (propylene glycol - traces, hypromellose (E 464) - 0.458 mg, titanium dioxide (E 171) - 4.026 mg, crimson dye [Ponso 4R] (E 124) - 0.401 mg, iron oxide black (E 172) - 0.130 mg, iron oxide red (E 172) - 0.020 mg).

Opagloss® 6000 (carnauba wax (E 903) - 0.075 mg, beeswax (E 901) - 0.075 mg, shellac (E 904) - 0.150 mg, ethanol 95 ° - traces).

Description

Pink, round biconvex film-coated tablets.

Pharmacotherapeutic group

Angioprotective agent.

ATX Qty: C05CA03

Pharmacological properties

Pharmacokinetics

Rapidly absorbed from the gastrointestinal tract, found in plasma 2 hours after ingestion. The maximum plasma concentration is reached 5 hours after ingestion. It is evenly distributed and accumulated in all layers of the wall of the vena cava and saphenous veins of the lower extremities, to a lesser extent - in the kidneys, liver and lungs and other tissues. Selective accumulation of diosmin and/or its metabolites in venous vessels reaches a maximum by 9 hours after ingestion and persists for 96 hours. Excreted by the kidneys 79%, intestines - 11%, with bile - 2.4%.

Indications for use

As part of complex therapy:

To eliminate the symptoms of lymphovenous insufficiency of the lower extremities: a feeling of heaviness or fatigue in the legs, pain;
- additional treatment for violation of microcirculation:
- symptomatic therapy of acute hemorrhoids.