Contrykal. Kontrykal ® (Contrykal) Kontrykal instructions for use

We want to warn you right away that the instructions for use allow using contrycal only under the supervision of a doctor. It is strictly forbidden to use contrycal without an appointment due to the unpredictability of possible side effects of this drug.

The main active ingredient of contrical is aprotinin. It belongs to the pharmacological group of proteliase inhibitors. The chemical properties of this drug allow it to be successfully used in various acute conditions in which it is necessary to prevent increased platelet aggregation, reduce blood viscosity and preserve the vitality of cellular structures. Especially often kontrykal finds application in acute pancreatitis, pancreatic necrosis and exacerbations of chronic inflammatory diseases of the pancreas.

The drug is used only in a hospital in the form of intravenous drip. Any other methods of application do not bring a satisfactory result. It is for this reason that contrycal tablets are not produced and are not used to treat humans.

Mechanism of action of contrycal

At its core, the drug contrykal is a polyvalent chemical compound that has an inhibitory effect on the proteliases of human cells. Penetrating through the cell membrane, contrykal has:

1. resistance to protein degradation;
2. restorative effect on fibrin fibers of tissues;
3. normalizing effect on hemostasis and metabolic intracellular processes.

In the cells of the pancreas, the drug contributes to the activation of various enzymes, such as trypsin, kallikrein. These substances prevent the death of pancreatic tissues, thus inhibiting the process of decay as a result of a massive inflammatory and lytic process.

The pharmacological ability of the active substance contrycal to have a hemostatic effect is widely used. By reducing the level of platelet aggregation, contrykal reduces the risk of developing coagulopathy and the development of thrombosis of various collateral great vessels. This allows the use of the drug contrykal in the postoperative periods for the prevention of deep vein thrombosis.

Forms of release by the pharmacological industry

Currently, two dosage forms are allowed for the practical use of counterkal:

1. concentrated preparation for dilution before intravenous drip;
2. lyophilized form for intravenous administration with preliminary dilution in physiological saline.

Other forms are not produced and are not used for the purpose of treatment and prevention of diseases. Therefore, if you are offered to buy countercal in tablets or in the form of an ointment, then know that this is a fake and is not an acceptable dosage form.

The drug contrykal - use in various conditions

The main purpose of the pharmacological drug contrykal is to remove the lytic effect in various congestion in the tissues of the pancreas. Kontrykal finds application in:

• acute and chronic pancreatitis;
• necrosis of pancreatic tissue;
• surgical interventions in the tissue of the pancreas;
• carrying out functional diagnostics;
• operations on organs closely located with the pancreas.

Other indications for the use of contrycal are associated with hemostatic properties and include:

• angioedema of soft tissues;
• postoperative and postpartum bleeding;
• severe menstrual disorders, expressed in the form of heavy bleeding;
• prevention of the development of nonspecific parotitis in acute form;
• shock conditions (collapse, pain shock, burn disease);
• complex combined injuries of the head and substance of the brain.

The drug is completely contraindicated during pregnancy and breastfeeding. Contrycal should also not be used if there is a confirmed allergic reaction to bovine protein.

Side effects are manifested acutely in the form of systemic and local allergic reactions, disorders of the cardiovascular system, digestive disorders.

The introduction of contrical is allowed only in the position of the patient lying down. Initially, 50 thousand units of action are slowly injected intravenously. Then, with normal tolerability of the drug, the dose increases gradually to 500 thousand units.

Compresses can be used to stop local external bleeding. To do this, a sterile gauze napkin is impregnated with a solution of 200 - 300 thousand units of counterkal and applied to the wound surface for 30 minutes.

The daily dosage for children is calculated by the formula: 20 thousand units for each kilogram of the baby's body weight. The dose may be divided into several intravenous infusions.

Is there contrical in tablets?

Separately, I would like to dwell on the fact that there is no contracal in tablets. To date, many manufacturers of dietary supplements attribute to them the properties that this drug has. But we want to warn you against using them. In addition to harm to the gastric mucosa, these substances will not bring anything. Unfortunately, the active drug substance contrical is available to the cells of the human body only after direct injection into the bloodstream by intravenous infusion. All other methods lead to the complete decomposition of aprotinin. When administered intramuscularly, this can lead to the development of a post-injection abscess. When ingested, acute gastritis may develop.

Kontrykal is a drug for the treatment of acute pancreatitis.

pharmachologic effect

The active substance of Kontrykal is aprotinin, which tends to inhibit proteolytic enzymes.

Aprotinin also inhibits the kallikrein-kinin system, so it can be used for various shocks.

The drug inactivates proteinases and plasmin, which makes it possible to use it in acute pancreatitis or coagulopathy.

The drug is metabolized in the kidneys, excreted in the urine for two days.

Release form

Produce Kontrykal in powder to dilute the solution for intravenous administration of the drug. You can buy Kontrykal with a solvent, in a package of 10 ampoules.

Analogues Kontrykal - Gordoks, Aproteks, Aprotinin, Ingiprol, Vero-narcap, Trasilol 500,000, Ingitril, Traskolan, Aerus.

Indications for use Kontrykal

According to the instructions, Kontrikal is prescribed for the treatment of acute forms of pancreatitis (including pancreatic necrosis), to prevent the occurrence of pancreatitis after surgery, fat embolism after fractures and surgery.

Good reviews about Kontrykal, used in the complex therapy of toxic, burn, hemorrhagic, traumatic shock.

Also, the use of Kontrykal is effective for bleeding due to coagulopathy (blood clotting disorders) provoked by hyperfibrinolysis.

Contraindications

According to the instructions, Kontrykal should not be used in case of hypersensitivity to the active substance, during pregnancy (up to 12 weeks). Caution should be observed when using Kontrykal in patients with polyvalent allergies.

After 12 weeks pregnancy, the drug can be used only for special indications.

You can not take Kontrykal simultaneously with urokinase, streptokinase, it can inhibit their action. Also, the agent is not compatible with antibiotics and solutions containing lipids, amino acids, dextran.

You can buy Kontrykal only with a prescription.

If there is a need to use analogues of Kontrykal, you should read their instructions, because. side effects and contraindications may vary.

Instructions for use Kontrykal

You can buy Kontrykal in ampoules 10,000, 30,000, 50,000 units.

For the treatment of acute pancreatitis, the agent is administered intravenously and as early as possible, at a dosage of 200,000 - 300,000 units. After that, for 24 hours. drip intravenously injected the same dose of funds. Treatment usually lasts until the improvement of the patient's condition and a positive change in these tests.

For the prevention of postoperative pancreatitis, an agent is prescribed at an initial dose of 200,000 IU, after which 100,000 IU are administered every 6 hours four times a day.

To eliminate shock, Kontrykal is started at a dose of 200,000 units per day, and every 4 hours thereafter. – 140 000 units.

To prevent fat embolism, the use of Kontrykal begins with a dose of 200,000 units, which is administered at a low rate intravenously. After that, 200,000 units are administered intravenously per day.

For the treatment of coagulopathy, according to the instructions, Kontrykal is prescribed to be administered at a dose of 300,000 IU at a low rate intravenously, then every 4 hours. - drip intravenously at 140,000 units.

Positive feedback about Kontrykal, used to stop birth bleeding. Assign to start 700,000 - 1,000,000 IU intravenously and then 700,000 IU every hour until bleeding is eliminated.

The drug is prescribed for children at the rate of 14,000 units per 1 kilogram of the child's weight. The drug is administered to children intravenously or drip (at a low speed, not more than 5 ml / min), in the supine position. Before use, Kontrykal is diluted with a solution of sodium chloride 0.9%. Enter the solution immediately, it can not be stored.

Side effects

The remedy can lead to allergic reactions, increased heart rate, sweating, weakness, shortness of breath, nausea, blue skin.

There are reviews about Kontrykal that there is a high risk of side effects after repeated administration of the drug, but they can also occur after the first injection.

In case of side effects, it is necessary to cancel the drug and use analogues of Kontrykal.

Sincerely,

Name:

Contrycal

Pharmacological
action:

Polypeptide derived from the lungs of cattle. Blocks the kallikrein-kinin system.
Inhibits both total proteolytic activity and the activity of individual proteolytic enzymes.
It is a polyvalent protease inhibitor (including plasmin, kininogenase, trypsin, chymotrypsin, kallikrein, including those that activate fibrinolysis).
Reduces fibrinolytic activity of the blood, inhibits fibrinolysis, has a hemostatic effect in coagulopathy.
Aprotinin activity is expressed in kallikrein inactivating units (KIE), in trypsin inactivating units of the European Pharmacopoeia (Ph.Eur.U), and also in antitrypsin units (ATrU). 1 Ph.Eur.U corresponds to 1800 CIE. 1 ATRE corresponds to 1.33 CIE.
Pharmacokinetics
Aprotinin, being a polypeptide, is inactivated in the gastrointestinal tract.
It is excreted in the urine as inactive decay products. T1 / 2 in the terminal phase is 7-10 hours.

Indications for
application:

Pancreatitis (acute, exacerbation of chronic), pancreatic necrosis;
- performance of diagnostic studies and operations on the pancreas (prevention of enzymatic autolysis of the pancreas during operations on it and adjacent organs of the abdominal cavity);
- prevention of acute nonspecific postoperative parotitis;
- bleeding on the background of hyperfibrinolysis: post-traumatic, postoperative (especially during operations on the prostate gland, lungs), before, after and during childbirth (including with amniotic fluid embolism);
- polymenorrhea;
- angioedema;
- shock (toxic; traumatic, burn, hemorrhagic);
- extensive and deep traumatic tissue damage;
- as an adjuvant therapy - coagulopathy characterized by secondary hyperfibrinolysis (in the initial phase, before the onset of the effect after the use of heparin and replacement of coagulation factors); massive bleeding (during thrombolytic therapy), during extracorporeal circulation;
- prevention of postoperative pulmonary embolism and bleeding; fat embolism in polytrauma, especially in fractures of the lower extremities and bones of the skull.

Mode of application:

For acute pancreatitis: the introduction of Kontrykal should begin as early as possible, the drug is administered intravenously, at a low rate, at a dose of 200,000 - 300,000 IU, then the same dose of Kontrykal is administered intravenously during the day.
Therapy continues until the improvement of objective (analysis data) and subjective symptoms (improvement of the patient's condition).
Prevention of pancreatitis during surgical interventions: the initial dose of Kontrykal is 200,000 IU, then 100,000 IU four times a day, every 6 hours.
shock treatment: the initial dose of Kontrykal is 200,000 IU / day, then 140,000 IU every 4 hours.
Prevention of fat embolism: initial dose of 200,000 IU intravenously at a low rate, then 200,000 IU / day intravenously drip.
With coagulopathy: initial dose of 300,000 IU intravenously at a low rate, then 140,000 IU intravenously, every 4 hours.
Bleeding during childbirth: initial dose of 700,000 - 1,000,000 IU intravenously, then 700,000 IU every hour until bleeding stops.

For children the daily dose of Kontrykal is 14,000 IU per 1 kg of the child's body weight.
Kontrykal is administered intravenously by stream (at a low rate, not more than 5 ml / min) or drip, the drug should be administered when the patient is in the supine position. Before administration, a 0.9% NaCl solution is added to the contents of the vial.
The prepared solution should be administered immediately, the introduction after long-term storage is unacceptable.

Side effects:

From the side of the immune system: anaphylactic shock, angioedema.
From the skin and subcutaneous tissue: skin rash, maculopapular rash, urticaria, pruritus, discoloration of the skin.
Gastrointestinal disorders: nausea, vomiting, especially with rapid administration.
From the hepatobiliary system: abnormal liver function, jaundice, liver failure.
Cardiac disorders: arrhythmia, tachycardia, ventricular tachycardia, atrial fibrillation, decrease / increase in blood pressure, shortness of breath, chest pain, myocardial ischemia, myocardial infarction, coronary artery thrombosis, pericarditis.
Neurological disorders: psychotic reactions, hallucinations, confusion, tremor, agitation, dizziness, convulsions.
From the urinary system: acute renal failure, anuria, renal tubular necrosis, increased plasma creatinine.

Vascular disorders: embolism, thrombosis, arterial thrombosis, pulmonary embolism.
From the respiratory system, chest organs and mediastinum: shortness of breath, cough, bronchospasm, chest pain, pulmonary edema.
From the side of the musculoskeletal system and connective tissue: arthralgia, myalgia.
Metabolic disorders, metabolism: hyperglycemia, hypokalemia, acidosis, hypervolemia.
From the blood and lymphatic system: DIC syndrome, coagulopathy, leukocytosis, thrombocytopenia, decreased prothrombin.
Other: general weakness, increased sweating, hyperthermia, thrombophlebitis at the site of infusion.
With repeated administration of aprotinin (within 6 months after the first injection), allergic reactions of varying severity can occasionally occur.
Even when a second injection of aprotinin does not cause any symptoms, a third injection can lead to reactions ranging from allergic to anaphylactic. In such cases, the injection / infusion of aprotinin should be stopped immediately.
If necessary, start anti-shock therapy according to usual clinical standards.

Contraindications:

DIC (with the exception of the coagulopathy phase);
- I and III trimesters of pregnancy, lactation period;
- hypersensitivity to aprotinin;
- Hypersensitivity to bovine protein.

Before starting therapy, it is desirable to conduct a skin test for the patient's individual sensitivity to aprotinin.
With indications of a history of allergic reactions before starting therapy with aprotinin, the use of histamine H1 receptor blockers and corticosteroids is recommended.
With hyperfibrinolysis and DIC, aprotinin can be used only after all manifestations of DIC have been eliminated and against the background of the preventive effect of heparin.
Carefully use in patients who have received muscle relaxants within the previous 2-3 days.

Kontrykal is a drug intended for the treatment of acute pancreatitis. Produced in the form of a lyophilizate for the preparation of a solution for injection.

Pharmacological action of Kontrykal

Kontrykal is an inhibitor of fibrinolysis.

In accordance with the instructions for Kontrykal, the active ingredient of the drug is aprotinin. The excipient in the composition of the drug is mannitol.

You can buy Kontrykal complete with a special solvent, which is an isotonic solution of sodium chloride.

When using Kontrykal, the active substance of the drug exhibits the properties of a polyvalent protease inhibitor. The drug deactivates the most important pathophysiological protease reactions in the development process, which are contained in blood plasma, tissue and cell elements (kallikrein, chymotrypsin, trypsin, plasmin) due to the formation of reversible stoichiometric enzyme-inhibitor complexes. The therapeutic effect of Kontrykal is due to the blunting of the proteolytic effect of plasmin, as well as the suppression of the activation of plasminogen functions by autogenous activators.

The instructions for Kontrykal noted that the drug has a wide range of inhibitory effects, which makes it possible to use it as a therapeutic and prophylactic agent for violations of the functions of various enzyme systems.

The activity of the active substance of the drug is expressed in KIE (kallikrein inactivating units) and in ATP (antitrypsin units).

When administered intravenously, Kontrykal is rapidly distributed in the extracellular space and accumulates in the liver. The period of complete elimination of the drug from the body is 4 hours, excreted by the kidneys.

Kontrykal and analogues of the drug affect the kallikrein-kinin system, which helps to eliminate shock.

Indications for use Kontrykal

The drug is prescribed to people who have:

• shock conditions;
• Acute pancreatitis;
• Hemorrhagic complications of a severe form that occur during thrombolytic therapy;
• Bleeding associated with hyperfibrinolysis of various etiologies (including postoperative), as well as bleeding before, during and after childbirth.

In accordance with the reviews, Kontrykal is effective in the prevention of pancreatitis resulting from the operation.

Method of application and dosage

You can buy Kontrykal in ampoules of 10,000, 30,000 and 50,000 units.

With the primary signs of acute pancreatitis, intravenous injections of Kontrykal are prescribed at a dose of 200,000 to 300,000 units, after which drip intravenous administration of the same dose is recommended for 24 hours. Therapy should be continued until the improvement of the clinical and general condition of the patient.

In order to prevent the development of pancreatitis in the postoperative period, it is recommended to administer Kontrykal at an initial dose of 200,000 IU, after which 100,000 IU 4 times a day with an interval of 6 hours.

In the treatment of shock conditions, the drug is prescribed at an initial dosage of 200,000 IU per day, then 140,000 IU every 4 hours.

To eliminate coagulopathy, a slow intravenous administration of the drug is prescribed at an initial dosage of 300,000 IU, after which 140,000 IU are dripped every 4 hours.

According to reviews, Kontrykal is effective in stopping birth bleeding. The initial dose for intravenous administration of the drug should be 700,000-1,000,000 IU with the transition to 700,000 IU every hour until the bleeding is completely eliminated.

For children, Kontrykal is prescribed at the rate of 14,000 IU per 1 kg of body weight intravenously by stream or drip at a low rate in the supine position. Before administration, the drug should be diluted with 0.9% sodium chloride solution. Ready solution is not subject to storage.

Side effects of Kontrykal

In reviews of Kontrykal, there are reports that the drug can cause adverse reactions from the body. During therapy, it is possible to develop hypersensitivity to the components of the drug and various allergic reactions in the form of a skin rash, itching, redness, and even anaphylactic shock.

With repeated administration of Kontrykal, the risk of adverse reactions increases significantly. The development of side effects is possible with the initial use of the drug.

When using Kontrykal, it is possible to increase the heart rate and the intensity of sweating, the occurrence of general weakness of the body, blue skin, nausea, and shortness of breath.

Contraindications for use

In accordance with the instructions, Kontrykal is contraindicated in people who are hypersensitive to the components of the drug.

Medicine is not prescribed for women during pregnancy and lactation.

With caution, Kontrykal should be used in patients suffering from polyvalent allergies.

Overdose

There are no reports of cases of drug overdose in reviews of Kontrikal.

Kontrykal's analogs

In terms of chemical composition and therapeutic action, Kontrykal's analogues are Aerus, Traskolan, Ingitril, Vero-narcap, Ingiprol, Aprotinin, Aprotex, Gordox.

Additional Information

The simultaneous use of Kontrykal with streptokinase and urokinase is not recommended, since the drug may blunt their action. Also, you should not combine therapy with this medication with solutions and antibiotics, which include dextran, amino acids and lipids.

If symptoms of intolerance or allergy occur during therapy with Kontrykal, it is necessary to stop using the drug.

The instructions for Kontrykal indicate that the medicine should be stored in a dark, dry, cool and out of the reach of children place.

Shelf life - 36 months.

You can buy Kontrykal in pharmacies only with a prescription from your doctor.