Whether it is possible to apply fezam and tempalgin. Nootropic agent Actavis Phezam - reviews. Phezam indications for use

To improve cerebral circulation, doctors prescribe the drug "Phezam". Reviews of this remedy indicate that this medicine not only relieves dizziness and headache, but also improves efficiency, improves memory and concentration. The drug has a slight sedative effect and calms the central nervous system. It improves sleep, but does not cause daytime blockage or impair thought processes.

The composition of the medicine

"Phezam" is a combined remedy. It contains two active ingredients - piracetam and cinnarizine. These substances are nootropics, they improve blood circulation and metabolism in the brain.

Piracetam enhances glucose metabolism. Because of this, the nutrition of neurons and the speed of signal transmission in the brain improve. This helps to increase efficiency, concentration of attention, and activation of the intellectual capabilities of a person. In addition, piracetam increases blood circulation in those areas of the brain where there is oxygen starvation. The substance has neuroprotective properties and prevents the death of nerve cells in ischemic areas.

Cinnarizine dilates blood vessels, which improves blood supply and nutrition to the brain. However, this action does not affect the level of blood pressure. Cinnarizine also has a slight sedative effect. This allows you to somewhat reduce the exciting and stimulating effect of piracetam. The instructions for use and reviews of Phezam state that this drug does not cause insomnia, like many other drugs with piracetam. On the contrary, this medication promotes fast and sound sleep. This effect is achieved due to the content of cinnarizine in the preparation.

The drug is released in the form of capsules. Each of them contains 400 mg of piracetam and 25 mg of cinnarizine. The composition of the powder inside each capsule also includes auxiliary ingredients: lactose, magnesium and silicon compounds. The shell consists of gelatin and dye.

Indications

Instructions and reviews of "Phezam" indicate the effectiveness of the drug in the following diseases:

1. All types of cerebral circulatory disorders. The drug is used for atherosclerosis, conditions after strokes and traumatic brain injuries, as well as for osteochondrosis, accompanied by ischemic manifestations and headache.
2. Intellectual disorders caused by vascular pathology. The drug improves memory and thinking in senile dementia and psychoorganic syndrome. With aphasia associated with vascular disorders, the drug improves the patient's speech.
3. Diseases accompanied by dizziness and nausea. Such pathologies include Meniere's disease, labyrinthopathy, "seasickness".
4. Violations of memory, attention and mental function.
5. neurotic manifestations. Due to the mild sedative effect of the drug, patients' mood improves and anxiety disappears.

In addition, the drug is taken for prophylactic purposes. Reviews of Phezam tablets and instructions for use report that this remedy prevents discomfort during motion sickness in transport and "seasickness".

Also, the drug has found its application in pediatric practice. It is prescribed to children with mental retardation, poor academic performance, deterioration in concentration and memory.

Contraindications

There are absolute contraindications for the use of a nootropic drug. "Fezam" is forbidden to prescribe for the following diseases and conditions:

• liver and kidney failure;
• psychomotor agitation;
• pregnancy and lactation;
• chorea of ​​Huntington;
• acute stage of hemorrhagic stroke;
• allergies to drug components;
• children under 5 years of age.

There are diseases in which the drug is used with caution. These include:

• Parkinson's disease;
• low blood clotting;
• bleeding;
• increase in intraocular pressure.

In these cases, the drug is taken at a reduced dosage and under close medical supervision.

Unwanted Effects

Reviews of "Phezam" indicate that in most cases the drug is well tolerated by patients. Of the side effects in the first days of treatment, drowsiness most often occurred, which disappeared as the body adapted to the drug.

In addition, in some patients, the drug can cause dyspeptic symptoms: nausea, vomiting, diarrhea, dry mouth. In rare cases, skin allergic reactions are possible. They appear mainly in patients with hypersensitivity to the ingredients of the capsules.

How to take the drug

The dosage of the drug is determined by the attending physician, depending on the diagnosis and condition of the patient. Usually adults are prescribed 1-2 capsules three times a day, and children - 1-2 capsules 1-2 times a day. The medicine is used for no more than 3 months in a row. If necessary, the course of treatment is repeated after a break.

special instructions

At the beginning of treatment, the drug causes drowsiness. Therefore, you should refrain from driving a car and performing complex work.

During the period of therapy, it is also necessary to take medicines for high blood pressure, tranquilizers, antidepressants and antipsychotics with caution. These medicines can increase the inhibitory effect on the central nervous system of a nootropic drug.

Storage, price and analogues

Capsules are stored at a temperature not exceeding +25 degrees, they are suitable for use for 3 years.

The drug is dispensed from pharmacy chains by prescription. The price of the medicine is from 260 to 330 rubles (for 60 capsules).

There are structural instructions for use and reviews of these drugs indicate that they have a similar effect on the body. These medicines include:

• "Nookam";
• "Combitropil";
• "Pyracesin";
• "Omaron".

These drugs also contain piracetam and cinnarizine. The cheapest analogue is Combitropil. Its price ranges from 60 to 75 rubles. The cost of other drugs is slightly higher - from 130 to 250 rubles.

Which of these drugs is best? In reviews of Phezam analogues, it is reported that the action of these drugs and their side effects practically do not differ from each other, since the composition of the medicines is the same.

Phezam is a combined drug, the effectiveness of which is aimed at increasing blood circulation and metabolism in this area. As active ingredients in the composition of the drug is cinnarizine and piracetam.

In this article, we will consider why doctors prescribe Phezam, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Phezam can be read in the comments.

Composition and form of release

The Phezam preparation is produced in the form of cylindrical capsules, gelatinous, hard, size No. 0. Capsules are white, inside is a mixture of powder, which has a white or almost white color. The composition of the contents inside may contain conglomerates that turn into powder if you press on them.

• Phezam capsules contain two active ingredients - piracetam and cinnarizine.
• As additional ingredients in the composition of the product are present: lactose monohydrate, magnesium stearate, colloidal silicon dioxide.

Clinico-pharmacological group: a drug that improves blood circulation and brain metabolism.

What helps Phezam?

Among the main indications for the use of the drug are:

• depressive states and psychoorganic syndrome;
• psychogenic asthenia and labyrinthopathy;
• ischemic stroke and other disorders in the field of cerebral circulation;
• portal form of hypertension, accompanied by encephalopathy;
• underdevelopment of intellectual character in children;
• prevention of kinetosis and migraine;
• subcomatose and coma after brain injury and intoxication;
• damage to the central nervous system, accompanied by a decrease in mnestic and intellectual functions.

Pharmacological properties

The medicine activates the blood circulation of the brain, improves visual and auditory function. The presence of piracetam in the composition enhances energy metabolism, accelerates the reproduction of protein and the breakdown of glucose. The work of cinnarizine is to increase the resistance of cerebral capillaries to hypoxia, vasodilation. In this case, no change in pressure is observed.

The complex effect of active elements allows Phezam tablets to reduce blood viscosity and normalize the functioning of the vestibular apparatus. The drug has slight antihistamine properties, improves the elasticity of erythrocyte membranes.

Instructions for use

According to the instructions for use, Phezam must be taken orally, swallowed whole, without chewing, without violating the integrity of the shell and without pouring the powder into a glass of water. The capsule should be washed down with a small amount of water (at least half a glass) or any other liquid, with the exception of carbonated sugary drinks, coffee and caffeinated energy drinks.

• For adults, the drug is prescribed 1-2 caps. 3 times / day for 1-3 months, depending on the severity of the disease. The course of treatment is 2-3 times a year.
• Children over 5 years of age are prescribed 1-2 caps. 1-2 times / day. The course of treatment is 1.5-3 months.

You should try to always take Phezam capsules at the same time, for example, every day at 9-00 am, or daily at 8-00 and 18-00, depending on how many times a day it is recommended to drink the drug. Moreover, if a person missed a dose at the set time, then you should drink the capsule immediately, if the next term for taking Phezam has not come. If, after the missed capsule, the time for taking the next one has come up, then you should drink only one, not two, without trying to compensate for the forgotten dose of the drug.

Contraindications

There are a number of contraindications for the use of Phezam:

1. Chorea of ​​Huntington.
2. Age up to 5 years.
3. Allergic reactions.
4. Psychomotor agitation.
5. Pregnancy and lactation.
6. Severe renal failure (with creatinine clearance below 20 ml per minute).
7. Severe liver failure.

Caution should be exercised when used in the following situations: the presence of Parkinson's disease, impaired renal or hepatic function, impaired hemostasis, bleeding.

Side effects

According to reviews Phezam may cause side effects.

1. Allergic reactions: dermatitis, skin rash, swelling, itching, photosensitivity.
2. Digestive system: nausea, increased salivation, diarrhea, vomiting, abdominal pain.
3. Nervous system: nervousness, hyperkinesia, depression, drowsiness, dizziness, ataxia, headaches, insomnia, imbalance, agitation, confusion, hallucinations, anxiety.
4. Other side effects: increased sexual activity.

Pregnancy and lactation

Despite the lack of data on the presence of teratogenic effects of piracetam and cinnarizine, Phezam is contraindicated for use during pregnancy. Piracetam is excreted in breast milk, so if you need to use the drug during lactation, breastfeeding should be discontinued.

Analogues

Structural analogues for the active substance:

• Combitropil;
• NooKam;
• Omaron;
• Piracesin.

Attention: the use of analogues must be agreed with the attending physician.

Prices

The average price of FESAM in pharmacies (Moscow) is 250 rubles.

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Allochol tablets: instructions, reviews, analogues Calcium Gluconate tablets - instructions, reviews, analogues

Phezam belongs to the group of nootropic drugs that improve cerebral circulation, have a vasodilating and antihypoxic effect.

The main active ingredients are piracetam 400 mg and cinnarizine 25 mg.

- Nootropic. It activates metabolic processes in the brain by enhancing energy and protein metabolism, accelerating the utilization of glucose by cells and increasing their resistance to hypoxia. Improves interneuronal transmission in the central nervous system and regional blood flow in the ischemic zone.

Effectively blocks calcium in cells and increases the resistance of the walls of cerebral vessels to hypoxia. Shows moderate antihistamine activity, reduces the excitability of the vestibular apparatus, increases the tone of the sympathetic nervous system. Increases the elasticity of erythrocyte membranes, their ability to deform, reduces blood viscosity.

Rapidly and completely absorbed from the gastrointestinal tract. Cmax of cinnarizine in plasma is achieved after 1-4 hours, Cmax of piracetam - after 2-6 hours. Bioavailability is 100%.

Plasma protein binding of cinnarizine is 91%. Piracetam does not bind to plasma proteins. Penetrates into all organs and tissues, penetrates through the placental barrier. Selectively accumulates in the cerebral cortex, mainly in the frontal, parietal and occipital lobes, cerebellum and basal ganglia.

After oral administration, the absorption of cinnarizine is slow. The maximum concentration of cinnarizine in plasma is created after 1-4 hours. It binds to plasma proteins by 91%. It is actively and completely metabolized by CYP2D6 liver isoenzymes through dealkylation. T1/2 is 4 hours. 1/3 of the metabolites are excreted by the kidneys, 2/3 - through the intestines.

Indications for use

What helps Phezam? The drug is prescribed in case of diagnosis of the following diseases or conditions:

• Insufficiency of cerebral circulation (atherosclerosis of cerebral vessels, the recovery period of ischemic and hemorrhagic strokes, traumatic brain injuries, encephalopathy of various origins).
• Intoxication.
• Other diseases of the central nervous system, accompanied by a decrease in intellectual-mnestic functions (impaired memory, attention, mood).
• Psychoorganic syndrome with a predominance of signs of asthenia and adynamia, asthenic syndrome.
• Labyrinthopathy, Meniere's syndrome.
• Lagging intellectual development in children.
• Prevention of migraine and kinetosis.

In children from 8 years of age, Phezam is used to treat dyslexia as part of complex treatment (including speech therapy).

Instructions for use Phezam and dosage

Capsules are taken orally (orally) after meals, without grinding beforehand and washed down with water. Standard dosages, according to the instructions for use Phezam:

• adults with imbalances - 1 capsule 3 times a day. Adults with motion sickness - 1 capsule 30 minutes before a walk, and then every 6 hours if necessary;
• adults with disorders of cerebral circulation - 1 capsule 3 times a day;
• children with dyslexia - 1-2 capsules 1 or 2 times a day (depending on the severity of the disorders) for 1-3 months, but not more than 3 months in a row, if necessary, 2-3 courses of therapy per year.

It is important to consider:

• With simultaneous use with Phezam, it is possible to increase the sedative effect of drugs that depress the activity of the central nervous system, as well as ethanol, nootropic and antihypertensive drugs.
• During application, it is unacceptable to take alcoholic beverages.
• When conducting special tests, the drug may give false results for radioactive iodine and doping.
• With the simultaneous use of vasodilators enhance the effect of the drug.
• The drug improves the tolerability of antipsychotic drugs and tricyclic antidepressants.

Side effects

The use of the drug cause the following side effects:

• headache and dizziness;
• vomiting, nausea, diarrhea, dyspepsia;
• impaired coordination, lethargy and decreased psychomotor reactions;
• allergic reactions - urticaria, itching, angioedema, bronchospasm, eczema, skin rash.

If side effects occur, it is recommended to stop taking it and consult a doctor.

Contraindications

Hypersensitivity to piracetam, cinnarizine or any of the excipients included in the preparation. Other contraindications to the appointment of Phezam:

• Severe renal (creatinine clearance< 20 мл/мин) и/или печеночная недостаточность;
• Psychomotor agitation at the time of drug administration;
• Chorea of ​​Huntington;
• Children's age up to 5 years;
• Pregnancy and lactation;
• hemorrhagic stroke;
• Galactose intolerance, lactase deficiency or glucose-galactose malabsorption (contains lactose monohydrate).

With caution should be used for pathologies of the kidneys and liver, porphyria, hemostasis disorders.

Overdose

As a rule, Phezam is well tolerated by patients, and when taking large doses of the drug, there are no significant side effects that require discontinuation of treatment. Overdose may cause abdominal pain.

• There is no specific antidote.

Pregnancy and lactation

The drug is contraindicated for use during pregnancy and lactation. Contraindicated in children under the age of 5 years.

Analogues Phezam, list of drugs

1. Amilonosar,
2. Vinpotropil,

When choosing analogues, it is important to understand that the instructions for the use of Phezam, the price and reviews of drugs of similar action do not apply. It is important to consult a doctor and not to make an independent replacement of the drug.

Price in pharmacies in Moscow and Russia: Omaron 400 mg + 25 mg 30 tablets - from 115 to 142 rubles, the cost of 90 tablets - from 310 to 375 rubles, according to 739 pharmacies.

A similar pharmacological effect on the body is exerted by:

1. Acefen,
2. Demanol,
3. memotropil,
4. Combitropil,
5. pantogam,
6. pyriditol,
7. Cellex,
8. Encephabol.

Released by prescription. Store in a dry, dark place and out of the reach of children at a temperature not exceeding +25°C. Shelf life - 3 years.

Photo of the drug

Latin name: Phezam

ATX Code: N06BX

Active substance: Piracetam + Cinnarizine (Piracetam + Cinnarizine)

Manufacturer: Balkanpharma-Dupnitza (Bulgaria)

The description applies to: 18.10.17

Phezam is a combined drug, the effectiveness of which is aimed at increasing blood circulation and metabolism in this area.

As active ingredients in the composition of the drug is cinnarizine and piracetam.

The drug "Phezam" has practically no adverse reactions and is well tolerated, which distinguishes it from analogues.

The cost of the drug is affordable, but despite this, a positive result can be achieved fairly quickly, subject to the dosages and recommendations of the doctor.

You should not self-medicate, because there is a high probability of undesirable consequences, which is associated with the presence of concomitant pathological processes that can only be determined by a highly qualified specialist.

Instructions for use

Among the main indications for the use of the drug are:

• ischemic stroke and other disorders in the field of cerebral circulation;
• portal form of hypertension, accompanied by encephalopathy;
• subcomatose and coma after brain injury and intoxication;
• damage to the central nervous system, accompanied by a decrease in mnestic and intellectual functions;
• depressive states and psychoorganic syndrome;
• psychogenic asthenia and labyrinthopathy;
• underdevelopment of intellectual character in children;
• prevention of kinetosis and migraine.

Dosing of the drug should be carried out by a specialist after receiving the results of the diagnostic studies.

It is important not to self-medicate to prevent the development of unwanted effects.

The drug "Phezam" is predominantly dosed as follows:

• Adults- 1 or 2 capsules three times a day for 2 months or more, depending on the complexity of the course of the pathological process.
• children- 1-2 capsules at least 2 times a day, for at least 1 month, in accordance with the severity of the disease.

The absorption of active substances in the body occurs quite quickly. Absorption processes occur in the gastrointestinal region. The maximum concentration of cinnarizine is observed after 2-4 hours, and piracetam after 4-6 hours.

The greatest amount of active substances accumulates in the heart, kidneys, kidneys and liver, as well as in the brain. Piracetam is excreted in the urine after 1.5 days by 60%, and cinnarizine with feces and urine after 5 hours.

It should be noted that during treatment with Phezam, it is not recommended to take tests and conduct diagnostic tests, since there is a high probability of distorting the results obtained.

Release form and composition

The drug "Phezam" is produced in capsules for oral use. One capsule contains about 400 mg of piracetam and about 25 mg of cinnarizine.

As auxiliary substances, the preparation includes gelatin, titanium dioxide and colloidal silicon, magnesium stearate and lactose.

Beneficial features

Phezam is an effective tool designed to improve blood circulation in the brain and activate metabolic processes in the body. At the same time, glucose utilization increases, which helps to improve the course of metabolic processes, microcirculation and platelet inhibition.

The active components of the drug are aimed at protecting the brain from various damages that may be the result of hypoxia.

The substances that make up Phezam affect the functions of the body in different ways:

• Cinnarizine- blocks calcium channels, having a pronounced effect on the vessels in the brain. With its help, cerebral circulation is accelerated, which helps to increase the resistance of soft tissues to the development of hypoxia. At the same time, there is a decrease in the excitability of the vestibular apparatus.
• Piracetam- is a nootropic substance that increases the effectiveness of cinnarizine and accelerates metabolic processes.

The toxicity of the active substances that make up Phezam is minimal. The therapeutic effect develops after taking the drug inside after a few hours, which depends on the characteristics of the human body individually.

Side effects and possible contraindications

You should not undergo treatment with this drug if you have an individual intolerance to the components that it contains.

It is also not recommended to take Phezam in violation of renal and hepatic functions, in the presence of parkinsonism and children under the age of five. An absolute contraindication to the passage of therapy is the period of lactation and pregnancy.

Among the possible side effects, taking Phezam, you may encounter dermatological reactions. In some cases, photosensitivity, itching and a characteristic rash occur.

In some cases, there is a headache, dyspepsia and insomnia. Among the possible adverse reactions is an increase in sexual activity. When such symptoms appear, it is recommended to stop treatment.

Interaction with other drugs

With the drug "Phezam" you should not take other medications without prior consultation with your doctor. This may increase the sedative effect of the drugs used.

In this case, inhibition of the activity of the central nervous system, a decrease in the effectiveness of ethanol and antidepressants are possible.

Phezam increases the effectiveness of antihypertensive and nootropic drugs. It can improve the tolerance of tricyclic antidepressants and antipsychotics.

It should be noted that the cinnarizine contained in the drug causes a positive reaction in doping tests in athletes.

Drug therapy can cause changes in the results when determining the amount of radioactive iodine in the body.

Terms and conditions of storage

Phezam is recommended to be stored in a place protected from excessive humidity and the sun. The optimum storage temperature is between 15 and 25 degrees. The shelf life of the medicinal product, subject to the recommendations for storage, is at least 2 years.

Price

The cost of the Fezam drug varies depending on the manufacturer and distributor. On the territory of Russia, the cost of the drug ranges from 213 to 262 rubles. In Ukraine, the price of a medicine varies from UAH 75.84 to 78.26.

Analogues

The drug Phezam is prescribed if it is necessary to improve mental activity, to concentrate, as well as for migraines and changeable mood.

The medicine is affordable at its cost, but despite this, most people are trying to buy analogues of the drug at a lower cost.

Despite the safety of these drugs, prior consultation with a doctor is a mandatory criterion for successful treatment.