What is the replacement for buserelin long. Buserelin long and depot what is the difference, side effects. Application: dosing regimen and treatment regimen
pharmachologic effect
Synthetic analogue of natural GnRH. Competitively binds to the receptors of the cells of the anterior pituitary gland, causing a short-term increase in the level of sex hormones in the blood plasma.
The use of the drug in therapeutic doses leads (on average after 12-14 days) to a complete blockade of the gonadotropic function of the pituitary gland, thus inhibiting the release of LH and FSH. As a result, there is a suppression of the synthesis of sex hormones in the ovaries and a decrease in the concentration of estradiol (E2) in the blood plasma to postmenopausal values.
Pharmacokinetics
When administered intranasally, the drug is completely absorbed through the nasal mucosa.
Small amounts are excreted in breast milk.
T 1/2 is about 3 hours.
Indications
Hormone-dependent pathology of the reproductive system due to absolute or relative hyperestrogenism:
- endometriosis (pre- and postoperative periods);
- uterine fibroids;
- hyperplastic processes of the endometrium;
- treatment of infertility (during the program of in vitro fertilization).
Dosing regimen
At treatment of endometriosis, uterine fibroids, endometrial hyperplastic processes the drug is administered into the nasal passages after their cleansing at a dose of 900 mcg / day. A single dose of the drug when the pump is fully pressed is 150 mcg. The daily dose of the drug is administered in equal portions, one injection into each nostril 3 times / day at regular intervals (6-8 hours) in the morning, afternoon and evening. Treatment with Buserelin should begin on the first or second day of the menstrual cycle, administered continuously throughout the course of treatment. The course of treatment is 4-6 months.
At infertility treatment by in vitro fertilization the drug is administered intranasally, one injection (150 mcg) into each nostril 3-4 times / day at regular intervals. The daily dose is 900-1200 mcg. Buserelin is prescribed at the beginning of the follicular (on the 2nd day of the menstrual cycle) or in the middle of the luteal phase (21-24 days) of the menstrual cycle preceding stimulation. After 14-17 days, with a decrease in estradiol in the blood serum of patients by at least 50% of the initial level, the absence of cysts in the ovaries, the thickness of the endometrium is not more than 5 mm, stimulation of superovulation with gonadotropic hormones begins under ultrasound monitoring and control of the level of estradiol in the blood serum. If necessary, the dose of Buserelin may be adjusted.
Side effect
From the side of the central nervous system: headache, dizziness, nervousness, fatigue, sleep disturbance, drowsiness, decreased memory and ability to concentrate, emotional lability, development of depression or worsening of its course.
From the sense organs: tinnitus, impaired hearing and vision (blurred vision), a feeling of pressure on the eyeball.
From the endocrine system:"flushing" of blood to the skin of the face and upper chest, increased sweating, vaginal dryness, decreased libido, pain in the lower abdomen, demineralization of bones; rarely - menstrual bleeding (usually during the first weeks of treatment).
From the side of the cardiovascular system: palpitations, increased blood pressure (in patients with arterial hypertension).
Allergic reactions: urticaria, pruritus, skin flushing, very rarely - bronchospasm, anaphylactic and / or anaphylactoid shock, angioedema.
From the digestive system: nausea, vomiting, thirst, diarrhea, constipation, loss of appetite, weight gain or loss.
From the side of laboratory indicators: decreased glucose tolerance, hyperglycemia; changes in the lipid spectrum; increased activity of serum transaminases, hyperbilirubinemia; thrombocytopenia or leukopenia.
Others: in isolated cases - nosebleeds; pulmonary embolism; swelling in the ankles and feet; weakening or strengthening of hair growth on the head and on the body; back pain, joint pain.
Local reactions: irritation of the nasal mucosa, dryness and pain in the nose.
Contraindications for use
- pregnancy;
- lactation period;
- Hypersensitivity to the components of the drug.
WITH caution the drug should be used for arterial hypertension, diabetes, depression.
Use during pregnancy and lactation
The use of the drug during pregnancy and lactation is contraindicated.
Overdose
Currently, cases of overdose of Buserelin have not been reported.
drug interaction
Simultaneous use of Buserelin with other drugs containing sex hormones (for example, in the ovulation induction mode) may contribute to the occurrence of ovarian hyperstimulation syndrome.
With simultaneous use Buserelin may reduce the effectiveness of hypoglycemic agents.
Terms of dispensing from pharmacies
The drug is dispensed by prescription.
Terms and conditions of storage
List B. The drug should be stored out of the reach of children, protected from light at a temperature of 8 ° to 25 ° C. Shelf life - 3 years.
special instructions
Patients with any form of depression during the period of treatment with Buserelin should be under close medical supervision.
Ovulation induction should be carried out under strict medical supervision.
In the initial stage of drug treatment, the development of ovarian cysts is possible.
A second course of treatment should be started only after a careful assessment of the ratio of the expected benefit and the potential risk of developing osteoporosis.
Patients using contact lenses may experience signs of eye irritation.
Given the intranasal route of administration, irritation of the nasal mucosa is possible, sometimes nosebleeds. The drug can be used for rhinitis, but before using it, the nasal passages should be cleared.
The use of the drug Buserelin in combination with surgical treatment for endometriosis reduces the size of pathological foci and their blood supply, inflammatory manifestations and, consequently, reduces the time of surgery, and postoperative therapy improves results, reducing the frequency of postoperative relapses and reducing the formation of adhesions.
Influence on the ability to drive vehicles and control mechanisms
During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.
Buserelin is an agent for fighting malignant tumors. The drug is used if the growth of the neoplasm depends on the production of hormones. In the treatment of such tumors, synthetic analogues of pituitary releasing hormones are used. Buserelin is one such analogue of natural hormones. Buserelin long is a prolonged form of the drug. Due to the long action, it is used once every few weeks.
In contact with
The composition of the drug
The medicinal substance of the drug is Buserelin acetate. The composition of the drug also includes copolymer compounds of lactic and glycolic acids, carmellose sodium, polysorbate-80 and d-mannitol. Busereling Long is available as a powder. It is diluted in a solvent and injected intramuscularly. The powder bottle contains 3.75 mg of the active ingredient - Buserelin acetate. One package of Buserelin Long contains a bottle of powder, a solvent in an ampoule, a syringe, 2 needles (for solvent and for injection), 2 napkins and a knife for opening the ampoule.
The medicinal effect of the drug
At the first stage of treatment with the drug, the content of gonadotropins and sex hormones increases. This increase in hormonal levels is temporary.
14 days after the injection of Buserelin long production of gonadotropins by the pituitary gland is blocked. In women, the production of pituitary hormones responsible for the maturation of follicles in the ovaries stops. As a result, the level of female sex hormones is sharply reduced. The content of estrogen in young women falls to the levels characteristic of the menopause. Doctors call this condition medical pseudomenopause.
In men, the action of the drug leads to a sharp drop in the level of androgens (male sex hormones). The indicators of sex hormones fall to the level of the post-castration period. Doctors call it pharmacological castration. Patients need to remember that during treatment with Buserelin Long, the decrease in estrogen and androgen levels is reversible. After cessation of therapy, the content of sex hormones returns to normal levels.
For what diseases is the drug used?
Instructions for use Buserelin long speaks of the following indications for treatment drug:
- diseases of the uterus caused by an excess of estrogens (uterine fibroids, endometriosis, endometrial hyperplasia);
- breast tumors (with intact menstrual function and intact estrogen and progesterone receptors);
- before and after operations for endometriosis (the drug reduces endometriosis lesions and the formation of adhesions after surgery);
- hormone-dependent forms of prostate cancer;
- before in vitro fertilization (IVF) - the drug suppresses the natural synthesis of estrogens, which makes it possible to create an artificial hormonal status necessary for embryo replanting.
Who should not take Buserelin Long?
Buserelin long is a potent drug that greatly changes the hormonal status of a person. That's why Not every patient is shown such a tool:
Possible side effects when taking the drug
When treated with such a potent drug side effects not excluded.
- From the side of the central nervous system, dizziness, headache, insomnia, memory loss and absent-mindedness, fatigue are possible. Those suffering from depressive disorders may worsen their mental state.
- On the part of the sense organs, hearing and vision impairment, tinnitus, a feeling of pressure on the eyes are possible.
- The cardiovascular system may also respond to the drug. Possible increase in blood pressure, tachycardia.
- Manifestations from the digestive organs are expressed in dyspeptic symptoms, impaired appetite.
- In patients prone to allergies, skin rashes and itching are possible. Bronchospasm, anaphylactic shock, and edema are very rarely observed.
- Very often there are side effects from the endocrine organs, since the drug is an analogue of pituitary hormones. Many women complain of flushing to the face, increased sweating, decreased libido, pain in the lower abdomen, increased bone fragility, dryness in the vagina. This is due to the ability of Buserelin long to dramatically reduce the level of female sex hormones. In men, due to a low level of androgens, there is an increase in the mammary glands (gynecomastia), a decrease in potency, rare and difficult urination.
- In patients undergoing treatment for prostate cancer, symptoms may worsen in the first days of treatment with the drug.
- All side effects are aggravated by the use of alcohol during the course of treatment.
During therapy with Buserelin long, changes in the blood test are possible: a decrease in leukocytes and platelets, an increase in glucose levels, changes in the lipid composition of the blood.
Buserelin long treatment regimen
This drug belongs to potent drugs, so its use is permissible only as directed by a doctor.
In the treatment of malignant tumors of the breast and prostate make 1 injection (3.75 mg) intramuscularly 1 time in 4 weeks. The course of treatment takes a long time and is carried out under close medical supervision.
In the treatment of pathologies of the female genital organs associated with an excess of estrogen (endometriosis, fibroids, endometrial hyperplasia), also give 1 injection every 4 weeks. According to the instructions for the drug, treatment begins in the first 5 days of the menstrual cycle. The course of treatment lasts from 3 to 6 months. Therapy before surgery for uterine fibroids should last about 3 months.
Before the IVF procedure the first injection of Buserelin long is done either on the second day of the menstrual cycle, or in the period from the 21st to the 24th day. Two weeks after the injection, the level of estrogen decreases by 2 times. After that, an ultrasound examination is done to exclude ovarian cysts. Then, with the help of gonadotropic hormones, superovulation is stimulated under ultrasound monitoring.
special instructions
The instructions for the drug indicate features of the use of Buserelin long.
Interaction of buserelin with other drugs
The drug is not recommended for use together with estrogenic agents. Simultaneous use of Buserelin and estrogens can cause ovarian hyperstimulation and cyst formation. Buserelin may reduce the effect of the use of hypoglycemic drugs. This should be borne in mind by diabetic patients taking medication.
Many patients are interested in the cost per bottle of Buserelin Long. The price of this medicine in pharmacies can be from 3500 to 5500 rubles. Analogues of the drug for the active substance are:
The closest remedy is Buserelin depot. Both drugs are generics of the same drug.
Buserelin is used for the complex treatment of hormone-dependent malignant tumors in men and women. This remedy is available in the form of a nasal spray or solution for intramuscular injection. In a pharmacy, the medicine may be called: Buserelin-depot, Buserelin-long and simply Buserelin. This synthetic analogue of natural gonadotropin-releasing hormone is especially helpful in the treatment of endometriosis (the main complication of which is infertility).
The combination of a course of conservative treatment with Buserelin with surgical intervention for endometriosis significantly reduces blood loss during surgery and its duration. During the recovery period, the use of these hormones suppresses the development of the remaining foci of inflammation, improves the processes of tissue repair and regeneration.
Pregnancy after Buserelin depot or long can occur in 2-4 months. In addition to endometriosis, buserelin is used in the treatment of prostate cancer in men, breast cancer in women, and uterine fibroids.
Comparison of the types of manufactured drugs
Buserelin long and depot - what is the difference can be seen in the comparative table. And only the attending physician can tell which form is better to choose for successful treatment.
Buserelin | |||
| Active substance: | |||
| Treatment method: | Intramuscular injections | nasal spray | |
| Set: |
| 17.5 ml dark glass bottle with atomizer | |
| Buserelin acetate: | |||
| Excipients: |
| benzalkonium chloride and water for injection | |
| Solvent: 0.8% Mannitol solution | in 1 ml of water for injections | in 2 ml of water for injection | |
| Released: | Requires a doctor's prescription |
||
| Storage conditions: | Temperature not more than 25°C |
||
| Shelf life: | Vial with lyophilisate - no more than 2 years Ampoule with solvent - 3 years | Vial with lyophilisate - no more than 3 years Ampoule with solvent - 5 years | Up to 3 years |
Each drug is developed and manufactured according to certain technologies and principles. The substances included in its composition may, in combination with other pharmaceuticals, give undesirable results. Preparations containing buserelin should not be used in parallel with drugs that lower blood sugar levels and with sex hormones (during ovulation stimulation).
What diseases can prescribe Buserelin
Treatment with this drug is carried out with pathological diseases of the reproductive system:
- uterine fibroids;
- hyperplastic changes in the endometrium;
- ovarian tumors;
- mammary cancer;
- prostate cancer.
Buserelin has proven itself well in the treatment of infertility using in vitro fertilization. It suppresses the work of the hormonal system of the woman herself and makes it possible to artificially control the processes of maturation of the egg, its fertilization and implantation in the uterus. It helps a woman to successfully conceive.
What happens in the body under the influence of buserelin
Buserelin is a synthetic analogue of gonadotropin-releasing hormone (GnRH for short). It belongs to stimulating hormones and effectively stimulates the pituitary gland. The active work of this endocrine gland turns off the production of follicle-stimulating and luteinizing hormones and completely stops ovulation in women. During treatment, the content of estradiol in the blood is very low - at the level of postmenopausal values, and the physical and psychological state of patients corresponds to the period of sexual extinction (mood swings, hot flashes and strong heartbeat).
Under what circumstances is the drug contraindicated?
Buserelin should not be taken alone (without a doctor's prescription). The doctor will definitely check the amount of hormones in the blood, conduct an ultrasound examination of the internal organs and other necessary tests.
A hormonal preparation containing the substance buserelin is not prescribed if:
- The woman is pregnant. The use of medication while carrying a child can lead to a delay in the development of the embryo or miscarriage. Immediately after childbirth, it is also impossible to undergo a course of treatment if the woman is breastfeeding the baby. The drug has the ability to penetrate into milk and affect the baby.
- The woman began her menopause.
- The patient is experiencing depression. Taking Buserelin may worsen the psychological state.
- The diagnosis is diabetes mellitus or high blood pressure. Vessels in these diseases become fragile and can not withstand the additional load.
- The patient has not reached puberty (so as not to destroy the emerging hormonal background).
- With individual intolerance to the components of the drug.
How does the body as a whole respond to treatment?
The brain controls all processes inside a person, producing certain hormones. Any interference in this complex process causes deviations in the work of all organs. That is why Buserelin is taken only under the supervision of a doctor: in order to control and timely minimize negative manifestations. Patients describe the following side effects:
| Among women | In men |
| Depression, insomnia, tearfulness | Exacerbation and intensification of the underlying disease, severe bone pain |
| Headache | Muscle weakness in the legs |
| Vaginal dryness | urinary retention |
| Decreased sex drive | Decreased potency |
| Bleeding, similar to menstrual (in the first weeks of admission); pain in the lower abdomen | Gynecomastia (breast enlargement) |
| tides | Swelling of the legs, face |
| Increased sweating | |
| Hyperemia (redness) of the skin | |
| Urticaria and other allergic reactions (up to anaphylactic shock) | |
| Loss of calcium from bones (leads to osteoporosis) | |
| High blood pressure and tachycardia (with weak blood vessels, nosebleeds may begin) | |
| Sense of smell worsens, vision becomes fuzzy and blurry | |
| Nausea and vomiting, diarrhea or constipation | |
| Loss of appetite (causes marked fluctuations in weight) |
Nasal spray Buserelin
Endometriosis is most often treated with drops. They have a more affordable price than the drug for intramuscular injection. The daily norm (900 mcg) is divided into three doses. From one spray, the body receives 150 mcg of the drug. The scheme of reception is as follows: one injection into each nostril three times a day. The nose must be clean so that all the medicine gets to its destination. Runny nose is not a contraindication to the course of treatment. The main thing is to monitor the cleanliness and patency of the sinuses. Salt solutions can be used to pre-cleanse the nose from accumulated mucus.
The main disadvantage of this form of administration is the exact observance of time intervals. Between doses (injections) can take from 6 to 8 hours. Even a night's rest will have to be adjusted according to the medication schedule. The course lasts 3-6 months and, according to patients, requires a lot of patience and self-discipline.
The use of the drug in ampoules
In the form of injections, Buserelin therapy follows a simpler scheme than with a spray: an intramuscular injection is given every 28 days. For each diagnosis, there is a specific method of taking the drug:
- If treatment is being carried out for endometriosis, uterine fibroids or endometrial hyperplastic processes, then the first injection is given in the period from 1 to 5 days from the onset of menstruation. Subsequent injections are given at intervals of 4 weeks. The course of therapy is from 3 to 6 months.
- Men with prostate cancer and women with breast cancer are given injections in a similar way.
- In the treatment of infertility or in order to prepare for IVF, the first injection can be given on the second day of the cycle (the follicular phase is just beginning) or in the period from 21 to 24 days (luteal phase in the middle). 2 weeks after the administration of the drug, the amount of estrogen in the blood plasma will be halved, and if the ultrasound examination did not show problems in the uterus and ovaries in the form of a cyst, then the doctor prescribes stimulation of the ovulation process (gonadotropic hormones are used). This complex procedure is performed under ultrasound monitoring. During therapy, the level of estradiol is constantly monitored, and the doctor can change the dose of Buserelin depending on the situation.
How to prepare a solution for injection
Pharmacy packaging of the drug for intramuscular injection contains a pair of vials and a syringe with two needles. In one vial is the drug, and in the second - the solvent. Needles are needed: one for mixing the medicine, the other for injection. The solvent is drawn up with a syringe and injected into the capsule with the main suspension. Shake the mixture thoroughly and allow the drug to dissolve completely. The needle on the syringe is then changed and the injection can be performed.
The medication is prepared immediately before the introduction into the body strictly according to the instructions. To avoid accidents with an intramuscular injection, an injection should be made in a treatment room.
This page contains a list of all Buserelin-Long analogues by composition and indications for use. A list of cheap analogues, and you can also compare prices in pharmacies.
- The cheapest analogue of Buserelin-Long:
- The most popular analogue of Buserelin-Long:
- ATH classification: Buserelin
- Active ingredients / composition: buserelin
Cheap analogues of Buserelin-Long
| # | Name | Price in Russia | Price in Ukraine |
|---|---|---|---|
| 1 | triptorelin | 1919 rub | 134 UAH |
| 2 | triptorelin Analogue by indication and method of application | 2617 rub | 893 UAH |
| 3 | goserelin Analogue by indication and method of application | 3200 rub | 750 UAH |
| 4 | buserelin acetate Analogue in composition and indication | 3285 rub | 1850 UAH |
| 5 | triptorelin acetate Analogue by indication and method of application | 5420 rub | -- |
When calculating the cost cheap analogues of Buserelin-Long the minimum price was taken into account, which was found in the price lists provided by pharmacies
Popular analogues of Buserelin-Long
The list of drug analogues based on the statistics of the most requested drugs
All analogues of Buserelin-Long
The above list of analogues of drugs, which indicates buserelin-long substitutes, is the most suitable, since they have the same composition of active ingredients and match the indications for use
Analogues by indication and method of application
| Name | Price in Russia | Price in Ukraine |
|---|---|---|
| leuprorelin | -- | -- |
| leuprorelin | -- | -- |
| 16753 rub | 2437 UAH | |
| leuprorelin | 16753 rub | 2437 UAH |
| leuprorelin | -- | -- |
| leuprorelin | 7875 rub | 1926 UAH |
| goserelin | 3200 rub | 750 UAH |
| triptorelin | 2617 rub | 893 UAH |
| triptorelin | 8076 rub | 1915 UAH |
| triptorelin | 1919 rub | 134 UAH |
| triptorelin acetate | 5420 rub | -- |
To compile a list of cheap analogues of expensive drugs, we use the prices provided by more than 10,000 pharmacies throughout Russia. The database of drugs and their analogues is updated daily, so the information provided on our website is always up-to-date as of the current day. If you have not found the analogue you are interested in, please use the search above and select the medicine you are interested in from the list. On the page of each of them you will find all possible options for analogues of the desired medicine, as well as prices and addresses of pharmacies in which it is available.
How to find a cheap analogue of an expensive medicine?
To find an inexpensive analogue of a drug, a generic or a synonym, we first of all recommend paying attention to the composition, namely, to the same active ingredients and indications for use. The same active ingredients of the drug will indicate that the drug is a synonym for the drug, a pharmaceutical equivalent or a pharmaceutical alternative. However, do not forget about the inactive components of similar drugs, which can affect safety and efficacy. Do not forget about the advice of doctors, self-medication can harm your health, so always consult a doctor before using any medication.Buserelin-Long price
On the websites below you can find prices for Buserelin-Long and inquire about availability at a pharmacy nearbyBuserelin-Long instruction
INSTRUCTIONS
on the use of the drug
Buserelin-long
Compound
Lyophilisate for the preparation of a suspension for intramuscular administration of prolonged action, containing 3.75 mg of buserelin.
pharmachologic effect
Pharmacotherapeutic group:
anticancer agent, gonadotropin-releasing hormone (GnRH) analog.
Buserelin-long, indications for use
Hormone-dependent prostate cancer;
Mammary cancer;
Endometriosis (pre- and postoperative periods);
uterine fibroids;
Hyperplastic processes of the endometrium;
Treatment of infertility (during the program of in vitro fertilization (IVF)).
Contraindications
Pregnancy;
lactation period;
Hypersensitivity to the components of the drug
Dosage and administration
In hormone-dependent prostate cancer, Buserelin-long is administered at a dose of 3.75 mg (1 injection) intramuscularly (IM) every 4 weeks. In the treatment of endometriosis, hyperplastic processes of the endometrium, the drug is administered at a dose of 3.75 mg / m once every 4 weeks. Treatment should begin in the first five days of the menstrual cycle. Duration of treatment - 4 - 6 months. In the treatment of uterine fibroids, Buserelin-long is administered at a dose of 3.75 mg IM once every 4 weeks. Treatment should begin in the first five days of the menstrual cycle. Duration of treatment - before surgery 3 months, in other cases - 6 months; 2 In the treatment of infertility by in vitro fertilization (IVF), Buserelin-long is administered at a dose of 3.75 mg (1 injection) intramuscularly once at the beginning of the follicular phase (on the 2nd day of the menstrual cycle) or in the middle of the luteal phase (21-24 days ) of the menstrual cycle preceding stimulation. After blockade of the pituitary function, confirmed by a decrease in the concentration of estrogens in the blood serum by at least 50% of the initial level (usually determined 12-15 days after the injection of Buserelin-long), in the absence of ovarian cysts (according to ultrasound), the thickness of the endometrium does not more than 5 mm, stimulation of superovulation with gonadotropic hormones begins under ultrasound monitoring and control of the level of estradiol in the blood serum.
Side effects
Allergic reactions: urticaria, skin hyperemia, rarely - angioedema.
From the side of the central nervous system: frequent mood swings, sleep disturbances, depression, headache.
From the musculoskeletal system: with prolonged use - demineralization of bones, which is a risk of developing osteoporosis.
In women - headache, depression, sweating and changes in libido, dryness of the vaginal mucosa, pain in the lower abdomen, rarely - menstrual bleeding (during the first weeks of treatment).
In men, in the treatment of prostate cancer - during the first 2-3 weeks after the first injection, buserelin can cause exacerbation and progression of the underlying disease (associated with stimulation of the synthesis of gonadotropins and, accordingly, testosterone), gynecomastia, "hot flashes", increased sweating and decreased potency (rarely requires discontinuation of therapy), a transient increase in the concentration of androgens in the blood, urinary retention, "renal edema" - swelling of the face, eyelids, legs; muscle weakness in the lower extremities. At the beginning of treatment in patients with prostate cancer, a temporary increase in bone pain may occur; in this case, symptomatic therapy should be carried out. Separate cases of ureteral obstruction and spinal cord compression were noted.
Others: in isolated cases (a causal relationship has not been clearly established) - pulmonary embolism, dyspeptic disorders.
special instructions
In women Patients with any form of depression during the period of treatment with the drug should be under close medical supervision. Ovulation induction should be carried out under strict medical supervision. In the initial stage of drug treatment, the development of ovarian cysts is possible. 5 Before starting treatment, it is recommended to exclude pregnancy and stop taking hormonal contraceptives, however, during the first two months of using the drug, other (non-hormonal) methods of contraception should be used. After stopping treatment, ovarian function is restored. The first menstruation resumes after 3 months. In men In order to effectively prevent possible side effects in the first phase of the drug, it is necessary to use antiandrogens two weeks before the first injection of Buserelin-long and for two weeks after the first injection.
EFFECT ON ABILITY TO DRIVE AND OTHER MECHANISMS
Care should be taken when prescribing the drug to patients involved in potentially hazardous activities that require increased attention and speed of mental and motor reactions.
drug interaction
The simultaneous use of Buserelin-long with drugs containing sex hormones (for example, in the ovulation induction mode) may contribute to the occurrence of ovarian hyperstimulation syndrome. With the simultaneous use of Buserelin-long may reduce the effectiveness of hypoglycemic agents.
Overdose
No cases of overdose have been reported to date.
Storage conditions
In a dry, dark place at a temperature not exceeding 25°C.
Keep out of the reach of children.
In this article, you can read the instructions for using the drug Buserelin. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Buserelin in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Buserelin analogues in the presence of existing structural analogues. Use for the treatment of endometriosis, uterine fibroids and infertility in women, including during pregnancy and lactation. The composition and interaction of the drug with alcohol.
Buserelin- a synthetic analogue of natural GnRH. Competitively binds to the receptors of the cells of the anterior pituitary gland, causing a short-term increase in the level of sex hormones in the blood plasma.
The use of the drug in therapeutic doses leads (on average after 12-14 days) to a complete blockade of the gonadotropic function of the pituitary gland, thus inhibiting the release of LH and FSH. As a result, there is a suppression of the synthesis of sex hormones in the ovaries and a decrease in the concentration of estradiol (E2) in the blood plasma to postmenopausal values.
Compound
Buserelin acetate + excipients.
Pharmacokinetics
After subcutaneous administration, buserelin is completely absorbed from the gastrointestinal tract, in plasma it is observed 1 hour after administration. It accumulates in the liver, kidneys, and also in the anterior pituitary gland. Metabolized by tissue peptidases. It is excreted in the urine and bile unchanged and as metabolites.
When administered intranasally, the drug is completely absorbed through the nasal mucosa. Small amounts are excreted in breast milk.
Indications
Hormone-dependent pathology of the reproductive system due to absolute or relative hyperestrogenism:
- endometriosis (pre- and postoperative periods);
- uterine fibroids;
- hyperplastic processes of the endometrium;
- infertility treatment (during the in vitro fertilization program);
- hormone-dependent prostate cancer;
- mammary cancer.
Release form
Dosed nasal spray (Buserelin Depot).
Lyophilizate for the preparation of a sustained release suspension for intramuscular and subcutaneous administration of 3.75 mg (injections in ampoules for injection) (Bucerelin Long FS).
Instructions for use and regimen
Nasal spray
In the treatment of endometriosis, uterine fibroids, hyperplastic processes of the endometrium, the drug is administered into the nasal passages after their cleansing at a dose of 900 mcg per day. A single dose of the drug when the pump is fully pressed is 150 mcg. The daily dose of the drug is administered in equal portions, one injection into each nostril 3 times a day at regular intervals (6-8 hours) in the morning, afternoon and evening. Treatment with Buserelin should begin on the first or second day of the menstrual cycle, administered continuously throughout the course of treatment. The course of treatment is 4-6 months.
In the treatment of infertility by in vitro fertilization, the drug is administered intranasally, one injection (150 mcg) into each nostril 3-4 times a day at regular intervals. The daily dose is 900-1200 mcg. Buserelin is prescribed at the beginning of the follicular (on the 2nd day of the menstrual cycle) or in the middle of the luteal phase (21-24 days) of the menstrual cycle preceding stimulation. After 14-17 days, with a decrease in estradiol in the blood serum of patients by at least 50% of the initial level, the absence of cysts in the ovaries, the thickness of the endometrium is not more than 5 mm, stimulation of superovulation with gonadotropic hormones begins under ultrasound monitoring and control of the level of estradiol in the blood serum. If necessary, the dose of Buserelin may be adjusted.
Ampoules Buserelin Depot
With hormone-dependent prostate cancer - 3.75 mg intramuscularly every 4 weeks.
In the treatment of endometriosis, hyperplastic processes of the endometrium - 3.75 mg / m once every 4 weeks. Treatment should begin in the first five days of the menstrual cycle. Duration of treatment - 4-6 months.
In the treatment of uterine fibroids - 3.75 mg / m once every 4 weeks. Treatment should begin in the first five days of the menstrual cycle. Duration of treatment - before surgery 3 months, in other cases - 6 months.
In the treatment of infertility by in vitro fertilization - 3.75 mg / m once at the beginning of the folliculin (on the 2nd day of the menstrual cycle) or in the middle of the luteal phase (21-24 days) of the menstrual cycle preceding stimulation. After blockade of the pituitary function, confirmed by a decrease in the concentration of estrogens in the blood serum by at least 50% of the initial level (usually determined 12-15 days after the injection of Buserelin Depot), in the absence of cysts in the ovaries (according to ultrasound), the thickness of the endometrium does not more than 5 mm, stimulation of superovulation with gonadotropic hormones begins under ultrasound monitoring and control of the level of estradiol in the blood serum.
Rules for the preparation of a suspension and administration of the drug
The drug is administered only intramuscularly. Suspension for intramuscular injection is prepared with the supplied solvent immediately before administration. The drug should be prepared and administered only by specially trained medical personnel.
The bottle with Buserelin Depot should be kept strictly upright. Lightly tapping the bottle, you need to ensure that the entire lyophilisate is at the bottom of the bottle.
Open the syringe, attach a needle with a pink pavilion (1.2 × 50 mm) to it to withdraw the solvent.
Open the ampoule and draw the entire contents of the solvent ampoule into the syringe, set the syringe to a dose of 2 ml.
Remove the plastic cap from the vial containing the lyophilisate. Disinfect the rubber stopper of the vial with an alcohol swab. Insert the needle into the vial with the lyophilisate through the center of the rubber stopper and carefully inject the solvent along the inner wall of the vial without touching the contents of the vial with the needle. Remove the syringe from the vial.
The vial should remain motionless until the lyophilizate is completely soaked with solvent and the suspension is formed (approximately 3-5 minutes). After that, without turning the vial over, you should check for the presence of dry lyophilisate at the walls and bottom of the vial. If dry residues of the lyophilisate are found, leave the vial until completely soaked.
After there is no dry lyophilisate residue left, the contents of the vial should be gently mixed in a circular motion for 30-60 seconds until a homogeneous suspension is formed. Do not invert or shake the vial, as this may cause flakes to fall out and the suspension to be unusable.
You need to quickly insert the needle through the rubber stopper into the vial. Then lower the needle section down and, tilting the vial at an angle of 45 degrees, slowly draw the entire suspension into the syringe. Do not turn the vial upside down while typing. A small amount of the drug may remain on the walls and bottom of the vial. The consumption for the residue on the walls and bottom of the vial is taken into account.
Immediately change the pink pavilion needle to the green pavilion needle (0.8×40 mm), carefully invert the syringe and remove air from the syringe.
Buserelin Depot suspension should be administered immediately after preparation.
Using an alcohol swab, you need to disinfect the injection site. Insert the needle deep into the gluteal muscle, then pull the syringe plunger slightly back to make sure that there is no damage to the vessel. Inject the suspension intramuscularly slowly with constant pressure on the syringe plunger. If the needle is clogged, it is replaced with another needle of the same diameter.
Side effect
- headache;
- dizziness;
- nervousness;
- fatigue;
- sleep disturbance;
- drowsiness;
- decreased memory and ability to concentrate;
- emotional lability;
- development of depression or worsening of its course;
- noise in ears;
- impaired hearing and vision (blurred vision);
- feeling of pressure on the eyeball;
- flushes of blood to the skin of the face and upper chest;
- increased sweating;
- dryness of the vagina;
- decreased libido;
- pain in the lower abdomen;
- bone demineralization;
- menstrual bleeding (usually during the first weeks of treatment);
- heartbeat;
- increased blood pressure (in patients with arterial hypertension);
- hives;
- skin itching;
- skin hyperemia;
- bronchospasm;
- anaphylactic and/or anaphylactoid shock;
- angioedema;
- nausea, vomiting;
- diarrhea;
- constipation;
- loss of appetite;
- increase or decrease in body weight;
- hyperglycemia;
- changes in the lipid spectrum;
- thrombocytopenia or leukopenia;
- nosebleeds;
- pulmonary embolism;
- swelling in the ankles and feet;
- weakening or strengthening of hair growth on the head and on the body;
- pain in the back, joints;
- irritation of the nasal mucosa;
- dryness and pain in the nose.
Contraindications
- pregnancy;
- lactation period;
- hypersensitivity to the components of the drug.
Use during pregnancy and lactation
The use of the drug during pregnancy and lactation is contraindicated.
special instructions
Patients with any form of depression during the period of treatment with Buserelin should be under close medical supervision.
Ovulation induction should be carried out under strict medical supervision.
In the initial stage of drug treatment, the development of ovarian cysts is possible.
A second course of treatment should be started only after a careful assessment of the ratio of the expected benefit and the potential risk of developing osteoporosis.
Patients using contact lenses may experience signs of eye irritation.
Given the intranasal (spray in the nose) method of application, irritation of the nasal mucosa is possible, sometimes nosebleeds. The drug can be used for rhinitis, but before using it, the nasal passages should be cleared.
The use of the drug Buserelin in combination with surgical treatment for endometriosis reduces the size of pathological foci and their blood supply, inflammatory manifestations and, consequently, reduces the time of surgery, and postoperative therapy improves results, reducing the frequency of postoperative relapses and reducing the formation of adhesions.
The menstrual cycle and the restoration of menstruation is observed within 1-2 months after the end of taking Buserelin. At the same time, you can start planning a pregnancy.
If you drink alcohol together with Buserelin, consult your doctor.
For the treatment of prostate cancer should not be prescribed to patients after orchiectomy. At the beginning of treatment for prostate cancer, an exacerbation of the disease (usually less than 10 days) is possible, associated with an initial transient increase in the concentration of androgens in the blood ("flare phenomenon"). In this case, severe pain in the bones or at the site of the tumor, exacerbation of symptoms (including dysuria) are possible. Strengthening of neurological disorders in patients with spinal metastases can lead to temporary weakness and paresthesia in the lower extremities. The patient should be warned about the need to continue therapy, despite side effects that decrease or disappear during further treatment.
Influence on the ability to drive vehicles and control mechanisms
During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.
drug interaction
Simultaneous use of Buserelin with other drugs containing sex hormones (for example, in the ovulation induction mode) may contribute to the occurrence of ovarian hyperstimulation syndrome.
With simultaneous use Buserelin may reduce the effectiveness of hypoglycemic agents.
Buserelin's analogues
Structural analogues for the active substance:
- Buserelin FSintez;
- Buserelin depot;
- Buserelin long FS;
- buserelin acetate;
- Subprefact;
- Subprefact depot.
In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.