Pimafucin side effects. Instructions for use of pimafucin tablets - composition, indications, side effects, analogues and price. Indications for use Pimafucin
- pills;
- vaginal capsules;
- cream.
The medication does not cause allergies. Not a single case of allergy has been reported with the use of pimafucin. Pimafucin tablets, thanks to a special coating, dissolve only in the intestines. Pimafucin is active when used topically. Practically not absorbed in the gastrointestinal tract, through the skin or mucous membranes.
Pimafucin vaginal capsules are successfully used in the treatment of vaginal candidiasis (thrush). The therapeutic effect of the drug is also observed in vaginal discharge, inflammation and itching. With vaginal administration of suppositories, the drug acquires a foamy texture, due to which the active ingredient evenly and completely covers the inner surface of the vagina. Modern methods of biochemical studies of tissues have shown the complete absence of natamycin, used vaginally, in the blood and other body fluids. Also, its metabolites were not detected. This indicates the absence of a systemic effect of the drug.
Tablets Fungal infectious pathologies of the skin and mucous membranes. Among them:
- candidiasis of the oral mucosa (pseudomembranous, atrophic) in persons with general atrophy, weakened immunity, as well as after a long course of antibiotics, glucocorticoids or cytostatic drugs;
- mycosis of the external auditory canal (primary fungal, or in combination with Candida albicans infection);
- candidiasis of the skin and nails;
- intestinal candidiasis;
- vaginitis, vulvitis, vulvovaginitis, inflammation of the head of the penis, caused by infection with fungi of the genus Candida;
- fungal diseases of the skin;
- in combination with griseofulvin in the treatment of fungal skin diseases.
Vaginal capsules
Vaginitis, vulvitis, vulvovaginitis, developed as a result of infection with fungi of the genus Candida.
Fungal infections of the skin and mucous membranes. Among them:
- vulvitis, vulvovaginitis, balanitis, developed as a result of infection with fungi of the genus Candida;
- candidiasis of the skin and nails;
- otitis externa (primary fungal, or in combination with an infection of fungi of the genus Candida);
- fungal diseases of the skin.
Vaginal capsules
With vaginitis, vulvitis, vulvovaginitis - one capsule per day, immediately before bedtime. The capsule is injected as deeply as possible, in a horizontal position of the body. Course duration - 3-6 days. With vaginitis complicated by Candida albicans infection, additional use of Pimafucin tablets (one tablet 4 times a day for 1-3 weeks) is recommended to destroy candida in the intestine. With the elimination of the symptoms of the disease, it is necessary to continue therapy for several more days.
With vulvitis, vulvovaginitis, balanitis, the infected surface is treated with a cream 1-4 times a day. With the complication of the above diseases with Candida albicans infection, tablets or vaginal capsules of Pimafucin are additionally indicated. In case of fungal diseases of the skin (including candidiasis of the skin and nails, intertrigo in children), the infected areas are treated with cream 1-4 times a day. With external otomycosis, a cream is applied to the infected areas 1-4 times a day. Before applying the cream, the ear is cleaned. After applying the cream, a cotton or wool swab is inserted into the ear canal. The duration of the course is calculated individually. After the symptoms of the pathology have been eliminated, it is necessary to extend the course for a few more days. When heated, the vaginal capsules quickly dissolve, acquiring a foamy texture, due to which the drug evenly and completely covers the inner surface of the vagina. In the chronic or recurrent form of the disease, in combination with vaginal suppositories, Pimafucin tablets and cream are indicated.
Etal contained in vaginal capsules may cause some burning sensation in the genital area if this substance is intolerant. During menstruation, treatment with vaginal capsules is canceled. During therapy with capsules, sexual intercourse is permissible. However, it is necessary to examine both partners. If a Candida albicans infection is detected, the partner must also undergo therapy. Also during the course it is necessary to use barrier contraception.
Pimafucin is approved for use in newborns. Dermatomycosis of the skin, as a rule, develops in the folds (often in overweight people), between the phalanges, in the corners of the mouth, under the mammary glands, in the groin area. In people with diabetes, the development of ulcers, especially on the feet, is also due to the vital activity of infectious fungi. With candidiasis of the skin, it is necessary to treat the affected areas with Pimafucin cream 2-3 times a day. Considering that this pathology often recurs, it is recommended to use Pimafucin tablets in combination with the cream. Candidiasis worsens in most women already in the first trimester of pregnancy. Depending on the severity of the symptoms of the disease, on the pathogen, as well as on the duration of pregnancy, gynecologists recommend various drugs.
Pimafucin is one of the antifungal drugs approved for use during pregnancy and lactation. The active component of the drug - natamycin - is practically not absorbed in the gastrointestinal tract, through the skin and mucous membranes. It is also not found in blood and other biological fluids (including breast milk).
However, the opinion of doctors about the use of this drug during pregnancy often diverges. Many gynecologists consider Pimafucin to be an outdated and ineffective drug in comparison with newer antifungal agents, and some even consider it dangerous and recommend resorting to it only if absolutely necessary. In addition, for many women it does not help at all, and in rare cases, it aggravates the course of the disease. And yet, most gynecologists recommend Pimafucin as one of the safest antifungal drugs, in particular for pregnant and lactating women. As a rule, doctors recommend vaginal suppositories as the most convenient and safe dosage form of the drug. Store in a dry place, protected from direct sunlight, out of the reach of children, at a temperature below 25 degrees. Shelf life - 48 months. Clinical trials of the antifungal agent Pimafucin involved women with various types of vaginitis caused by protists, fungi and opportunistic microorganisms. The effectiveness of the drug was confirmed in all the tests. The best results were obtained in the treatment of vaginitis caused by Candida albicans infection (83-95%). The test results showed the high efficiency of Pimafucin in the treatment of recurrent forms of candidiasis and a decrease in the number of fungi of the genus Candida in the rectum after using the oral form of the drug. This study was carried out by the Scientific Center for Obstetrics, Gynecology and Perinatology of the Russian Academy of Medical Sciences (Moscow). The study involved 32 women in the first trimester of pregnancy. All women had severe symptoms of candidal vaginitis. Patients received one vaginal capsule (0.1 g of natamycin) once a day at bedtime. The duration of the course was 6 days. In parallel, women took Pimafucin in the form of tablets - 4 tablets per day, for 5 days. All women were contraindicated in sexual intercourse for 15-20 days.
On the 2nd-3rd day of treatment, all patients noted an improvement in well-being and a decrease in the severity of symptoms. At the end of treatment, the main symptoms of vaginitis were eliminated in 30 patients: vaginal discharge, vascular overflow, mucosal edema, itching and burning. The final microbiological examination of vaginal discharge showed the absence of fungal cells and spores.
Also, the patients improved their health and tone, the condition of the fetus, the symptoms of a threatened miscarriage were eliminated.
Unsatisfactory results of therapy were noted in patients who had been ill for a long time with recurrent candidal vaginitis and had repeatedly taken various antifungal medications. This, in turn, could contribute to the development of insensitivity of the infection to traditionally used drugs.
Thus, as a result of the treatment of candidal vaginitis with Pimafucin, complete recovery was recorded in the vast majority of pregnant women. This indicates the high efficacy of the drug in the treatment of candidal vaginitis. In addition, the absence of an embryotoxic effect of the drug, as well as a negative effect on the fetus, was noted. Ekaterina, 28 years old, Irkutsk At the 5th month of pregnancy, my candidiasis worsened (although it had not worsened for 2 years before). I ate sweets - and literally the next day, familiar symptoms appeared. Apparently pregnancy played a decisive role, after all, the hormonal background has changed. The gynecologist prescribed vaginal suppositories, which should not be used by pregnant women, so I had to look for a normal remedy myself. On the medical site I read about Pimafucin. One of the few drugs in the form of vaginal suppositories that is not contraindicated during pregnancy. The package contains 3 and 6 capsules. I bought a package with three capsules - it cost me 300 rubles. Used as directed before bed. The capsules are soft and very fragile, so you need to carefully pull them out, otherwise they may burst in your hands. The whole next day, the contents of the capsules flowed out, which created a lot of discomfort - I had to change three daily doses. But by the evening I already felt relief - the itching and burning sensation disappeared. Well, I decided to fix the effect, and used the two remaining capsules - I had to suffer for two days. As a result, it helped - the symptoms did not resume, and after the birth everything was in order. But then I decided to abstain from sweets. The product is good, I recommend it to everyone.
Anna, 36 years old, Moscow
Pimafucin has saved me more than once during pregnancy. The tool is completely harmless, has no side effects. Capsules are administered simply and without problems - no pain occurs. Perhaps this is one of the few drugs that can be safely used without a doctor's prescription, without risking either one's own health or the health of the child. True, there is one feature - during pregnancy, Pimafucin saves only for a certain period of time, because. the microbiocenosis of the vagina normalizes only after childbirth (at least it was so for me). Either way, this is the best product I've tried. Therefore, I advise you to try, and do not be afraid of the price - it's worth it.
Svetlana, 32 years old, Kharkiv
I bought Pimafucin after my candidiasis worsened after treatment with Vaginorm-S vaginal capsules. It costs a lot, of course, but I still decided to buy it. Then I decided not to breed amateur performances, and follow the recommendations of my gynecologist, so I bought a pack of 6 candles. I had to pay 500 rubles for it. The capsules are dense, and do not spread in the hands, as often happens. Introduced them for 6 days, one a day before bedtime. There were no side effects, thank God. True, during the treatment, the medicine constantly leaked out, I had to change several pads. But this is perhaps the only negative.
The symptoms began to disappear already on the second day, and by the 6th day there was no trace of them. A week after the end of the course, she passed a smear - everything is clean, no infection. Therefore, I can say with confidence - the drug is wonderful, try it - you will not regret it.
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Pimafucin - will help in difficult times - Polyene antibiotics
Polyene antibiotics
Polyene antibiotics are naturally occurring antifungals produced by various microorganisms. Their mechanism of action is that they bind strongly to ergosterol (a biologically active substance contained in fungal cells) of the fungal cell membrane, violating the integrity of the membrane, which leads to cell destruction. Polyene antibiotics are active against most pathogenic fungi and some protozoa, such as Trichomonas, Leishmania and Amoebas. Polyenes are resistant to fungi that cause trichophytosis and microsporia (ringworm).
All polyenes are practically not absorbed from the gastrointestinal tract when taken orally, as well as from the surface of intact skin and mucous membranes when applied topically. The first antibiotics of this series were nystatin and levorin, which had a lot of side effects. Pimafucin belongs to the last generations of polyenes.
The mechanism of action of pimafucin
Pimafucin (international non-proprietary name - natamycin) is an antifungal broad-spectrum polyene antibiotic from the macrolide group. Pimafucin binds sterols of cell membranes, violating their integrity and function, which leads to the death of microorganisms. Most pathogenic yeast fungi (including Candida genus) are sensitive to this antifungal antibiotic. Fungi that cause trichophytosis, microsporia and epidermophytosis (ringworm and fungal infections of the skin of the feet) are less sensitive to it. The addiction of infectious agents to pimafucin does not occur.
Pimafucin is practically not absorbed in the gastrointestinal tract (due to the enteric coating, it acts only in the intestine), from the surface of the skin and mucous membranes.
Pimafucin is used to treat fungal infections of the skin and mucous membranes of the intestines, ear, skin, nails, and genital organs. It is produced in the form of tablets for oral administration, vaginal suppositories, creams and suspensions for external use. Candles under the influence of body temperature quickly dissolve, forming a volumetrically spreading foamy mass, which contributes to a uniform distribution of the active substance.
Indications and contraindications for use
Indications for taking pimafucin are fungal diseases of the skin and mucous membranes caused by microorganisms sensitive to it (including in pregnant women, nursing mothers and newborns):
- candidiasis against the background of a decrease in the protective properties of the body (immunity), including with long-term use of hormonal contraceptives and certain drugs that suppress the immune system (for example, used to treat tumors);
- candidiasis caused by taking antibiotics;
- ear candidiasis;
- candidiasis of the skin and nails;
- intestinal candidiasis;
- genital candidiasis;
- dermatomycosis, including epidermophytosis of the skin of the feet.
A contraindication for taking pimafucin is hypersensitivity to the components of the drug.
Side effects in the treatment of pimafucin
When taking pimafucin orally in the first days of treatment, nausea and loosening of the stool are possible, which pass on their own and do not require discontinuation of the drug. With external use and the use of suppositories, mild irritation, a burning sensation on the skin and mucous membranes are possible. Alcohol, which is part of vaginal suppositories, can cause an allergic reaction.
How to use pimafucin
Tablets are used in the treatment of intestinal candidiasis, one tablet four times a day for seven days.
In the treatment of fungal diseases of the ear, the external auditory canal is cleaned, a cream is applied (once or twice a day) and a tampon made of natural material (for example, cotton, which absorbs liquid well) is placed in the auditory canal.
In the treatment of candidiasis of the genital organs, pimafucin is used in suppositories (one suppository per day for seven days), during menstruation the treatment is interrupted. Sexual intercourse during the treatment period is not contraindicated provided that both partners are treated.
For fungal diseases of the skin and nails, a cream and suspension are used, which are applied to the affected surface of the skin and nails once or twice a day.
Pimafucin is a high-quality antifungal drug that has almost no side effects. It is produced by a pharmaceutical company for Astellas Pharma Europe B.V. (Netherlands).
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Pimafucin - tablets
Pimafucin is a drug that is used to combat mycoses, the causative agents of which are yeast fungi. It is used for various types of thrush. Pimafucin tablets are used if topical preparations are not effective.
Release form and mechanism of action
Pimafucin is produced in the form of tablets of 100 mg in vials of 20 pcs. or in blisters.
The active ingredient of Pimafucin is natamycin, which is classified as a broad-spectrum antifungal polyene antibiotic from the group of macrolides.
It combines the sterols of the cell membranes of the fungus, thereby violating their integrity and negatively affecting the functions. This causes the fungus to die.
Yeast and yeast-like fungi, in particular Candida, are most sensitive to Pimafucin. Mushrooms from the genus dermatophytes are less sensitive to the action of this drug.
Pimafucin is produced in the form of enteric-coated tablets. Due to this, the drug begins to act only in the intestines and is practically not absorbed in the digestive tract.
Indications for use
Pimafucin tablets are used for the following diseases:
- Candidomycosis of the skin and mucous membranes caused by pathogens sensitive to Pimafucin;
- Candidiasis that develops after taking antibiotics or hormonal drugs;
- Onychomycosis;
- Otomycosis, the causative agent of which are fungi;
- Pimafucin may be an additional agent for the treatment of fungus during therapy with Griseofulvin.
Method of application and dosage
Tablets are taken orally, regardless of the meal, without chewing and drinking plenty of water.
With intestinal candidiasis, Pimafucin is prescribed 1 tablet 4 times a day. Patients under the age of 12 years - 1 tablet twice a day.
With long-term treatment of vaginitis caused by a fungus from the genus Candida, Pimafucin is prescribed 1 tablet 4 times a day. The course of treatment is from 10 to 20 days.
Other forms of release of Pimafucin are also used: cream and suppositories.
Side effects and contraindications
When taking Pimafucin in the first days, side effects may develop in the form of allergic reactions, nausea and diarrhea, which disappear on their own during treatment or after discontinuation of the drug.
- Hypersensitivity to the active substance or auxiliary components of the drug;
- Severe disorders of the liver and kidneys
special instructions
No significant interactions with other drugs have been found in Pimafucin tablets.
Analogues
An analogue of Pimafucin is Natamycin.
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Pimafucin tablets for a child or adult - how to take, dosage, contraindications and reviews
For the treatment of intestinal candidiasis in pregnant women, men or children, a gynecologist may prescribe Pimafucin tablets. They have a complex effect, are safe for use even in newborns, because the active ingredient natamycin in the composition is not absorbed by the blood. Familiarize yourself with the indications for the use of Pimafucin, dosage and contraindications.
Pimafucin tablets - instructions for use
The antifungal drug Pimafucin in tablets is available for the treatment of intestinal candidiasis, internal mycoses and other fungal diseases. According to the pharmacological classification, the drug belongs to the group of natamycin antibiotics, which selectively act on pathogenic pathogens. The active ingredient in the drug is natamycin.
One tablet of an effective antifungal antibiotic contains 100 mg of natamycin. The full composition of Pimafucin is shown in the table below:
Other forms of the drug contain:
- Suppositories - 100 mg of natamycin, excipients cetyl alcohol, solid fat, sorbitol, polysorbate, sodium bicarbonate, adipic acid.
- 1 g of cream accounts for 20 mg of natamycin, additional components are decyloleate, wax based on cetyl esters, cetostearyl alcohol, sodium lauryl sulfate, methyl parahydroxybenzoate, propyl parahydroxybenzoate, propylene glycol, purified water.
Release form
Pimafucin is available in the form of round tablets, enteric-coated white or almost white. The medicine is enclosed in 20 pieces in dark glass bottles and cardboard packs. Other formats of Pimafucin are vaginal suppositories (3 and 6 pieces in a PVC or aluminum blisters), cream for external use (plastic or metal tube 30 g), suspension for the treatment of the oral cavity and ear canal (2.5%).
Pharmacodynamics and pharmacokinetics
The active substance of Pimafucin, natamycin, belongs to the group of polyene antimycotics from the group of macrolide antibiotics, has a wide spectrum of action. It suppresses candida fungi, dermatophytes and other pathogenic microorganisms are considered less susceptible. The instructions for use emphasize that natamycin is active against all fungi, but doctors prefer to treat them only with candidiasis.
Natamycin has fungicidal activity, blocks specific components (sterols) of the cell membranes of pathogens, which leads to their death. In clinical practice, there were no cases of resistance (resistance) to the active substance. It is practically not absorbed in the digestive canal, is not absorbed from the mucous membranes and skin. Due to the enteric coating of Pimafucin tablets, their action occurs inside the intestine.
Indications for use
According to the instructions for use of the drug, the following indications for its use are distinguished:
- intestinal candidiasis;
- treatment of dermatomycosis, skin lesions;
- elimination of symptoms of thrush;
- acute pseudomembranous and acute atrophic candidiasis;
- treatment of patients with cachexia, immune deficiency, treated with antibiotics, corticosteroids, cytostatics;
- sanitation of the intestinal reservoir in candidiasis of the skin, mucous membranes, with advanced or chronic vaginal candidiasis, vulvitis, vulvovaginitis, balanoposthitis with increased secretions;
- complex treatment of systemic skin diseases;
- fungal infections of the genitals, skin, appendages of the skin, candidiasis of the nails.
Tablets are taken orally, regardless of the meal, since it does not affect the effectiveness of its antifungal components. Dosage of Pimafucin:
- with intestinal damage, adults take 100 mg of natamycin (1 tablet) four times a day, children - twice, the course of treatment is a week;
- with a persistent course of vaginitis caused by fungi of the genus Candida, together with local antifungal drugs (Pimafucin suppositories), to sanitize the focus of infection inside the intestine, you need to drink tablets 4 times a day, with a course of 10-20 days;
- in the treatment of thrush and its varieties on the genitals, the duration of treatment lasts up to three weeks (a break for the duration of menstruation is done only when using candles), together with a sexual partner;
- with candidiasis of the nails, along with the cream, tablets are used four times a day for a course of 2-3 months;
- with widespread candidomycosis of the skin, along with topical application of the cream, 4 tablets per day are drunk in a weekly course;
- with onychomycosis, together with the use of natamycin and cream, 4 tablets are taken per day for a course of 2-3 months;
- the duration of therapy for a fungal infection is set individually, after the disappearance of symptoms, treatment continues for several more days.
special instructions
Instructions for use of the medicinal product contains a section of special instructions. Small excerpts from it:
- the composition of the drug contains 66 mg of lactose monohydrate (milk sugar) and 122 mg of sucrose - patients with rare congenital intolerance to galactose, fructose, lactase deficiency, glucose-galactose malabsorption or sucrase-isomalt insufficiency should consult with their doctor before taking;
- tablets are not recommended for use in infants due to difficulty in swallowing;
- the drug does not affect the speed of psychomotor reactions, therefore it can be used when driving cars and dangerous mechanisms.
During pregnancy
Pimafucin is not forbidden to use during pregnancy. It is included in the complex treatment of thrush, which occurs due to changes in the hormonal background during childbearing, occurring in conjunction with a decrease in immunity and a violation of the normal bacterial flora. In case of a chronic infection or an advanced disease, a cream is additionally prescribed for the tablets, contraception to protect the partner's organs is assumed to be barrier means.
Pimafucin during lactation
If the thrush has struck the mammary glands of a nursing mother, gynecologists can prescribe Pimafucin tablets to her. They eliminate burning, pain, tingling in the nipples. Also, the drug treats candidiasis of the oral mucosa, mycosis of the ear canal. At the time of treatment, it is worth refusing to feed, because the medicine can worsen the quality of milk.
Pimafucin for children
The peculiarity of the drug is the lack of penetration into the gastrointestinal tract, which makes it attractive compared to other antibiotics for children. Pimafucin does not cause a large number of adverse reactions; it is prescribed for candidiasis of the gastrointestinal tract. Children's dosage is 100 mg (one tablet) twice a day. Older children can be prescribed up to four pieces, up to a year - part of the pill. Complex therapy with suppositories or cream is allowed.
drug interaction
Instructions for use Pimafucin in the form of tablets indicates that the drug interaction of the drug with other medicines was not detected. This means that you can safely combine funds, but only after consulting a doctor. It is allowed to take several varieties of Pimafucin in parallel to speed up recovery and reduce the time for therapy.
Contraindications
The drug Pimafucin in tablet form has few contraindications, because it is considered one of the safest antimycotics and antibiotics. The only warning for patients is hypersensitivity to natamycin or other derivatives of the drug. It is worth consulting with a doctor about taking medication for patients with diabetes mellitus, possible allergies.
Side effects and overdose
In the first days of taking the antibiotic, side effects may occur that disappear on their own with the course of treatment. These include nausea, vomiting, diarrhea, itching. If the symptoms become more pronounced or other adverse reactions join them, you should consult a doctor. According to the instructions, an overdose of the drug is unlikely due to its low absorption. Her cases are unknown in practice.
Terms of sale and storage
The drug is dispensed from pharmacies without a prescription. It is stored in a place protected from light and children at temperatures up to 25 degrees. The shelf life is four years.
Analogues
The tablet format of the drug is used only for the treatment and prevention of candidiasis, but they cannot treat thrush (vaginal and other). For the latter, candles and cream are used. There are no complete analogues of Pimafucin, but there are approximate substitutes for the treatment of gastrointestinal candidiasis, which have a systemic effect - they enter the bloodstream, act on all systems and organs of the body, have some toxicity to the liver and side effects, according to reviews:
- Irunin;
- Itraconazole;
- Mycozoral;
- Mycosist;
- Nystatin;
- Terbinafine;
- Fluconazole.
Pimafucin price
You can buy Pimafucin on the Internet or in the usual pharmacy departments. The price depends on the level of pricing of trading enterprises and the form of release. The approximate cost of Pimafucin of different formats is indicated below.
Broad-spectrum antibiotics do not always have the desired effect. In most cases, these drugs cause a number of side effects and include a number of contraindications. Also, such funds have a fairly high cost, which raises the question of the profitability of their purchase.
One such remedy is Pimafucin. This tool is relatively new, but it has already managed to win demand among buyers. The main advantages of Pimafucin are safety and efficacy.
Pimafucin is an antifungal agent related to broad-spectrum polyene antibiotics. This drug is remarkable in that it is able to suppress a number of pathogenic microorganisms and is used to treat such unpleasant diseases as thrush, nail candidiasis, and fungal diseases of the gastrointestinal tract.
The tool exhibits active fungicidal activity, which allows you to block the reproduction of microorganisms and even in the progression phase. The positive effect of Pimafucin was noted in relation to yeast-like fungi, dermatophytes.
The peculiarity of the drug Pimafucin lies in its harmlessness. Modern pharmaceutical technologies have made it possible to ensure that the drug is allowed to be used in relation to pregnant women, children and even infants.
The presence of various forms of release of Pimafucin allows you to choose the optimally convenient version of the drug. The substance does not have side effects on the body, but acts directly on the problem itself.
Release form and manufacturer
The drug Pimafucin is produced simultaneously in several forms. Each form is focused on a specific problem, which greatly facilitates the process of treatment and speeds up recovery.
The manufacturer of Pimafucin is the leading company Astellas, located in the Netherlands. European quality and reasonable price allowed this remedy to become advanced in the treatment of the main female problem - thrush.
Compound
Due to its universal composition, Pimafucin provides clear results within a few days after the start of treatment.
Pimafucin contains the main component - natamycin. Natamycin is a broad-spectrum macrolide antibiotic that can resist a number of fungal microorganisms.
This substance is not able to be absorbed into the blood and into the walls of the digestive tract. Also, Nitamycin is not absorbed from the skin and mucous membranes.
Additional components improve the clinical effect of the drug. In each type of drug, additional ingredients differ from each other.
Composition of Pimafucin tablets
Main components:
- Natacimin.
Additional:
- Potato starch;
- magnesium stearate;
- Lactose;
- Gelatin;
- Acacia;
- Methyl p-hydroxybenzoate;
- calcium carbonate;
- Kaolin;
- Talc;
- Cellulose acetate phthalate;
- Triacetin;
- White beeswax;
- titanium oxide;
- Sucrose.
Suppositories vaginal
Main components:
- Natamycin.
Additional:
- cetyl alcohol;
- Solid fat;
- Sorbitol;
- Polysorbate;
- sodium bicarbonate;
- Aipic acid.
Photo: Cream Pimafucin Cream Pimafucin
Main Component:
- Natamycin.
Additional:
- Decyloleate;
- Wax based on cetyl esters;
- Cetostearyl alcohol;
- Sodium lauryl sulfate;
- Methyl parahydroxybenzoate;
- Propyl parahydroxybenzoate;
- propylene glycol;
- Purified water.
Indications for use Pimafucin
Depending on the diagnosis, doctors recommend a specific form of Pimafucin.
So, tablets should be used in such cases:
- Otomycosis;
- External otitis caused by a fungus;
- Nail candidiasis;
- skin candidiasis;
- intestinal candidiasis;
- Vulvitis;
- vaginitis;
- Balanoposthitis;
- Dermatomycosis;
- Acute atrophic candidiasis;
- Acute pseudomembranous candidiasis.
Vaginal suppositories are prescribed in such cases:
- vaginitis;
- Vulvitis;
- Vulvovaginitis.
Suppositories are effective in case of damage by fungi of the genus Candida.
The cream is used to treat the following ailments:
- Diseases of the skin and mucous membranes caused by fungal microorganisms;
- Balanoposthitis;
- Vulvitis;
- Vulvovaginitis;
- skin candidiasis;
- Nail candidiasis;
- Dermatomycosis;
- Otitis externa.
You should not resort to using the drug on your own, as this can provoke certain difficulties in further treatment.
Instructions for use Pimafucin
It is necessary to take Pimafucin strictly according to the instructions, while observing the recommendations of the doctor. Also, the dosage regimen depends on the form of the drug.
Photo: Instructions for use Pimafucin Intestinal candidiasis - take 1 tablet at least 4 times a day. For children, the medication should be reduced to 1 tablet 2 times a day. Candidiasis - take 1 tablet 4 times a day. Candidiasis of the skin - take 1 tablet 4 times a day.
It is possible that the dose for a number of diseases is prescribed by the doctor individually, based on the patient's condition and the degree of progress of the disease.
Suppositories Pimafucin: 1 suppository is introduced into the vagina 1 time per day. It is advisable to carry out the procedure before going to bed.
Cream Pimafucin: the product is applied to the affected area of the skin at least 1 time per day. Also, the number of applications can be increased to 4.
Contraindications
Pimafucin is completely safe for the health of the patient and is not able to cause radical complications of the existing disease, and also not to provide the expected results from it. The only nuance that you need to be extremely careful with is over sensitivity to the components of Pimafucin. With the sudden detection of allergic reactions, the use of Pimafucin should be stopped and the hospital should be consulted to receive the necessary therapy.
Photo: Contraindications of the drug Pimafucin Pimafucin, as an antifungal antibiotic, is a broad-spectrum drug. The active substance of Pimafucin, Natamycin, has a fungicidal effect and leads to the death of fungal cells.
The majority of pathogenic yeast fungi are sensitive to the active substance Pimafucin. Dermatophytes are weakly sensitive to the component.
Side effects
Among the side effects of Pimafucin note:
- slight burning sensation in the area of application of suppositories;
- slight irritation of surrounding tissues;
- nausea, short-term lack of appetite in the first days of admission;
- diarrhea, followed by mild spasms in the intestinal area at the beginning of the drug.
It is important to tell your doctor about side effects not listed in the instructions if they occur. If suspicious symptoms appear or in case of persistent diarrhea or persistent nausea, you should immediately contact the clinic for medical assistance and doctor's recommendations for further taking Pimafucin.
Features of Pimafucin
suppositories
Pimafucin can be used during lactation and during pregnancy. Data on the negative effect of the drug on the fetus has not been identified.
Pills
Pimafucin can be used during pregnancy, as well as during breastfeeding. It is not recommended to use the drug in the treatment of infants. This is due to the possible difficulty in swallowing tablets by newborns.
Cream
The drug can be used during breastfeeding and during the period of bearing a child. There is no data on the adverse effects of Pimafucin crepe on the fetus. The cream is prescribed for children and newborns.
special instructions
Pimafucin vaginal suppositories dissolve quickly under the natural temperature effect of the female body. The structure becomes foamy, which allows the drug to be organically distributed over the tissues.
In case of frequent relapses or chronic course of the disease, Pimafucin (topically) can be supplemented with Pimafucin in the form of tablets or cream for external use.
In case of high sensitivity to cetyl alcohol, a woman may feel a slight burning sensation or a feeling of chill immediately after the introduction of the suppository. The therapy is not interrupted. The suspension of therapy occurs during menstruation.
During the period of using Pimaftsin candles, a break in intimate life is not required. But, without fail, it is worthwhile to conduct an examination of the sexual partner and, if signs of candidiasis are detected, treat your couple with Pimafucin. Otherwise, the treatment is not effective.
During . This is a prerequisite for intimate relationships during therapy.
An overdose of the drug is not feasible due to low absorption. There were no cases of drug overdose.
During the period of treatment with Pimafucin, the reaction rate does not worsen. The drug does not affect a person's attention in any way, as well as the ability to drive a car, does not interfere with the management of mechanisms and does not interfere with activities that require a quick response.
Interaction of Pimafucin with other drugs or alcohol
The drug interaction of Pimafucin with other drugs is not described.
Drinking alcohol and strong drinks during therapy is not prohibited. Alcohol does not adversely affect the effectiveness of the drug.
Price and analogues
The average price for Pimafucin in Russia is:
- Pimafucin tablets - 454 r. (package of 20 tablets);
- Suppositories - 500 r. (packing of 6 candles);
- Cream Pimafucin 2% - 304 r. (30 grams).
The drug has numerous analogues, among which:
- Primafungin;
- Natamycin.
These drugs are analogues of the active substance Pimafucin.
According to the therapeutic effect, several drugs are also distinguished, with similar qualities of effectiveness:
- Clotrimazole;
- Natamycin;
- Ecofucin.
A cheaper suppository is Primafungin. Despite a fairly wide range of analogues of the drug, the effectiveness of Pimafucin is unique, due to the specific composition of the components and their interaction.
When replacing Pimafucin prescribed in the clinic with another similar drug, you should consult with your doctor. Otherwise, the choice of another drug may lead to complications of the disease and a poor result of therapy. Also, Pimafucin analogues may have other side effects than the original medication.
Storage conditions
The use of Pimafucin is possible only if the rules for storing the drug are observed:
- The drug must be stored in conditions where the air temperature is from +15 to +25 degrees Celsius.
- Do not store the cream and vaginal suppositories in the refrigerator, the drug may lose its properties.
- The drug must be stored in a place protected from direct sunlight.
- It is not necessary to allow the storage of the drug in a place accessible to children and animals.
- Overfreezing and melting of suppositories and cream should not be allowed.
The drug is not used after the full expiration date:
- The shelf life of the tablets is 4 years from the date of issue.
- Shelf life of vaginal suppositories is 2 years from the date of issue.
- The shelf life of the cream is 4 years from the date of release of the drug.
The drug "Pimafucin" is available in the form of vaginal suppositories, tablets and ointments. It is a broad spectrum antifungal agent. It is intended for the treatment of diseases of the organs of the female reproductive system, which provoke yeast-like fungi. In reviews of Pimafucin tablets for thrush, they are called the number one choice.
The drug demonstrates maximum effectiveness against candidiasis. Therefore, doctors begin therapy for thrush with the appointment of this remedy. The principle of action of the drug is to use pronounced fungicidal properties. Its active substance violates the integrity of pathogenic membranes and destroys microorganisms. The maximum resistance to Pimafucin suppositories, reviews and instructions confirm this, dermatophytes show.
Purpose
Most often, the drug is prescribed for the treatment of skin and mucous membranes affected by fungal infections of various types. Its use is also justified in the treatment of candidiasis. The agent is practically not absorbed from the gastrointestinal tract, from the surface of the skin and mucous membranes. Brief list of indications:
- fungal lesions of the nail plates;
- trichomoniasis;
- inflammation of the vulva;
- vaginitis;
- otomycosis;
- dermatological candidiasis.
oral form
The reviews and instructions for the use of Pimafucin tablets say that the remedy showed excellent results in the treatment and prevention of colonization of the intestines by fungi of the Candida family. Their uncontrolled reproduction provokes long-term use of antibiotics, hormonal preparations containing corticosteroids, cytostatics.
The cost of a package of 20 enteric-coated tablets in pharmacies is approximately 600 rubles.
Soft dosage form
The cream is prescribed to patients suffering from candidiasis of the skin and mucous tissues. And also in cases of damage by dermatophytes and other yeast-like fungi. In reviews of the Pimafucin cream, it is said that the average cost of the drug in Russian pharmacies is 360 rubles. The drug is supplied in metal tubes. Cream weight - 30 g.
suppositories
The main indication for taking suppositories is an infectious and fungal infection of the vulva. They are produced in two configurations. One is designed for short-term treatment of thrush and involves a set of three suppositories packed in a cardboard box. Its price is 300 rubles.
The reviews and instructions for the use of Pimafucin suppositories say that in the treatment of advanced vulvitis and vaginitis of fungal origin, it is advisable to purchase a second set. It consists of six suppositories. The cost of the set is 520 rubles.
Choice of dosage
In inflammatory processes caused by yeast-like fungi in the vulva and vagina, one suppository is prescribed for six days. In some cases, the use of the drug for nine days is allowed. To insert the candle into the vagina as deeply as possible, you need to take a horizontal position and relax.
In the reviews on the use of Pimafucin candles, they say that the standard prescription regimen is not always effective. In this case, the treatment can be supplemented with an oral form. Take four tablets a day. The oral form is responsible for the sanitation of the internal surface of the intestine, which can also serve as a focus for the colonization of yeast-like fungi.
The duration of the therapeutic course is ten days. To enhance the effect of therapeutic measures, a mild form of the remedy is prescribed. In the instructions and reviews of the Pimafucin ointment, they claim that it has proven effective in destroying fungal infections of the skin of the partner's genitals. The cream is applied one or more times a day.
Balanoposthitis
As part of the drug therapy of the disease, the use of ointment has become widespread. It lubricates areas of the skin that have been colonized by fungi. The procedure is performed once a day. It is possible to increase the dosage. Instructions and reviews about "Pimafucin" in the form of a cream prove the high effectiveness of the drug.
Intestinal tissue damage
Thrush of the excretory system is treated with an oral form of the drug. Adults are advised to take four tablets each day. The duration of treatment is seven days. For children, the dose is halved. They need to take two pills. In reviews of Pimafucin, women give high marks to the results of treatment. They report the absence of side effects and good health during the therapeutic course.
Mycoses of the skin
With a dermatological lesion, a mild form of the drug is used. The ointment is applied to the affected area of the skin once a day. If necessary, the number of procedures can be increased. In the reviews of women about "Pimafucin" it is mentioned that this remedy has found application in pediatric practice. It is used to treat diaper rash in babies.
Otomycosis
Fungal lesions of the ear organs are subject to therapy with natamycin, the main active ingredient of the mild form of Pimafucin. With open access to the affected areas, they are regularly lubricated with ointment. In the instructions and reviews of Pimafucin, it is recommended to pre-clean the auricle. A tampon is used to introduce the drug into the middle section. Its surface is abundantly smeared with cream and gently inserted into the ear canal.
The duration of therapy is set individually. You can not stop treatment after the disappearance of the main symptoms. In reviews of the use of "Pimafucin" it is said that the best results are achieved in cases where patients used the ointment for several days after the complete disappearance of the pathological manifestations of the underlying disease.
Taking during pregnancy
The remedy is recommended by leading obstetricians and gynecologists for the treatment of thrush during the period of gestation and breastfeeding. The dosage of the drug is indicated by the attending physician. To date, this medication is included in the group of first choice in the treatment of lesions of the mucous membranes and skin with fungal infections in pregnant women and during lactation. Judging by the reviews, every second woman takes Pimafucin in the 1st trimester.
Side effects
Despite the good tolerability of the drug by patients, the following negative manifestations were recorded by doctors:
- burning in the vagina and on the skin;
- diarrhea;
- bouts of nausea.
All of the above side effects do not require special treatment and do not lead to discontinuation of the drug. They go away on their own a few days after the start of the therapeutic course.
Contraindications
The main obstacle to treatment may be individual intolerance to the active component. In this case, we are talking about natamycin. Another contraindication, which is indicated in the instructions for use of Pimafucin tablets and in reviews, is porphyria.
Special cases
Uniform distribution of natamycin contained in suppositories over the inner surface of the vagina is ensured by foaming excipients under the influence of natural body temperature. In some cases, this drug can be included in the complex therapy plan for dermatomycosis of various origins.
Burning and irritation of the vaginal mucosa, which appear during the use of suppositories, occur due to the addition of the drug to the composition of the drug. In the composition of the drug, its share is insignificant, but sensitive patients may feel tingling and dryness. This is stated in the reviews of the Pimafucin candles.
If the fungal infection recurs after a certain period of time after the use of suppositories, then the appointment of an oral form of natamycin is recommended. During menstruation, candles are not used, since their effectiveness is minimal. During the course of the therapeutic course, partners are advised to use barrier contraception and undergo a thorough examination by specialized specialists.
Women who use suppositories do not need to give up their sexual life. The safety of the active substance has been proven. Therefore, natamycin is prescribed for the treatment of newborns. In reviews of Pimafucin candles, young parents mention that pediatricians prescribed this drug to their children.
Storage rules
All forms of the medicinal product must be kept in dry rooms. The recommended air temperature in the warehouse varies between 15-25 °C. The shelf life of the oral and soft form of the medicinal product established by the manufacturer Temmler Italia S.r.L. is four years.
Suppositories should be used after twenty-four months. The instructions and reviews on the use of "Pimafucin" say that when the storage temperature is exceeded, the candles are destroyed. Suppositories foam. Their shape changes.
The composition of the tablets
List of components:
- 100 mg of natamycin;
- 80 mg of potato starch;
- 5 mg PVP;
- 2.5 mg magnesium stearate;
- 66 mg lactose;
- 3 mg gelatin;
- 7 mg gum arabic;
- 30 mg calcium carbonate;
- 14 mg taolin;
- 21 mg talc;
- 18 mg phthalate;
- 122 mg sucrose.
Excipients:
- methyl p-hydroxybenzoate;
- triacetin;
- beeswax.
Composition of vaginal suppositories
Main components:
- 700 mg fat;
- 100 mg natamycin
- 460 mg sorbitol;
- 690 mg cetyl alcohol.
Excipients:
- polysorbate;
- sodium bicarbonate;
- adipic acid.
Soft Form Composition
Main components:
- 20 mg natamycin;
- 100 mg decyloleate;
- 135 mg cetostearyl alcohol;
- 150 mg propylene glycol.
Excipients:
- wax;
- sodium lauryl sulfate.
Patient reviews
In the reviews and instructions for the use of "Pimafucin" it appears that the therapeutic course is generally not associated with the appearance of side effects. The treatment is effective. Patients highlight the following benefits of using this drug:
- proven safety;
- almost complete absence of contraindications;
- availability;
- sale without a doctor's prescription;
- an abundance of analogues;
- prompt disposal of thrush;
- the possibility of use during pregnancy and breastfeeding.
Analogues
Preparations that contain natamycin:
- "Primafungin";
- "Pimafukort".
"Primafungin"
"Primafungin" is produced by JSC "Avexima" (Russian Federation). Suppositories are packed in a cardboard box of three. The dosage of this drug is fully consistent with the instructions listed in the instructions for use "Pimafucin". Customer reviews confirm this.
One suppository contains 100 mg of natamycin. The drug has practically no systemic effect on the body. If during use a pronounced burning sensation appears, you should stop using this remedy and seek additional advice from your doctor.
"Primafungin" is sold in pharmacies without a prescription. Its price is about 200 rubles. List of indications:
- inflammation of the vulva;
- vaginitis regardless of etiology;
- damage to the skin and mucous membranes by fungi of the Candida family.
- The drug is approved for use during lactation and pregnancy.
"Pimafukort"
This drug is considered an analogue of Pimafucin. The reviews and instructions say that it also includes neomycin and hydrocortisone. These components provide a complex therapeutic effect. The drug is produced by the Italian pharmaceutical company Temmler Italia S.r.L.
According to the manufacturer's description, this remedy has a pronounced anti-inflammatory effect. It perfectly fights fungal infections of the skin and mucous membranes. Used externally. Packed in cardboard boxes. The metal tube contains 15 g of cream.
"Pimafukort" is not a complete analogue of "Pimafucin", the instructions for use, in the reviews about this, are different. It says that the level of absorption of hydrocortisone through the skin without wound lesions is three percent. If the integrity of the epidermis is violated, this value doubles. If there is an infection on the skin, then the degree of absorption reaches 15%.
When using "Pimafucort" in the treatment of children, it should be borne in mind that their susceptibility is higher than that of adults. The older the child, the lower the absorption rate. There are few side effects. In reviews of Pimafucin and Pimafucort, some patients with sensitive skin insist that they feel a pronounced burning sensation and dryness of the skin on which the ointment was applied. Localized redness was noted. Sometimes women complained of itching.
If you note one of the above actions associated with taking Pimafukort, then we are talking about the manifestation of allergic reactions. In this case, the therapeutic course is canceled, and the drug must be replaced. True, usually these symptoms subside on the third day of using the cream. Similar moments are described by patients in their reviews of Pimafucin.
With prolonged use of the cream in children, a syndrome of suppression of the action of the adrenal cortex is diagnosed. Such a reaction is rare and only in those patients who applied occlusive dressings and applied the agent to large areas of the skin.
Instructions for use
When using "Pimafukort" in the eyelid area, you need to remember about the possibility of increasing intraocular pressure, which can lead to the further development of cataracts. In the therapeutic treatment of open wound surfaces, the risk of toxic effects is allowed. The reviews about "Pimafucin", produced in a mild form, talk about the safety of the drug for children.
"Pimafukort" can also be used in pediatrics, but under the supervision of a doctor. The list of indications includes all kinds of dermatoses, complications after fungal and bacterial infections. Contraindications include juvenile acne, anogenital itching, allergic reactions to the introduction of allergic vaccination vaccines. Do not use the cream for ichthyosis, the presence of open wound surfaces, viral diseases of the epidermis.
"Pimafukort" is prescribed with caution to children under one year old. And in the instructions, reviews of "Pimafucin" confirm this, there is no such restriction. The interaction of "Pimafucort" with other drugs is not described. Cross-type hypersensitivity has been reported when using neomycin with paromomycin, kanamycin, aminoglycosides, gentamicin.
Dosage
Adults and adolescents apply the cream twice a day. The course of treatment should not exceed fourteen days. Pimafukort ointment is the number one choice for the treatment of dermatoses. Occlusive dressings are contraindicated in small children. There were no cases of drug overdose.
Doctors admit the possibility of toxic effects when applying the cream to the surface of the middle ear, provided that the integrity of the eardrum is damaged. In this case, "Pimafucin" is recommended. User reviews confirm the absence of side effects. To enhance the effect of exposure, other forms of the drug are used.
"Natamycin"
This drug is considered one of the most effective antibiotics aimed at combating fungal infections. Most often, this remedy is prescribed for the treatment of thrush. In pharmacies, it is represented by suppositories, oral and soft forms. Like Pimafucin tablets, reviews say that Natamycin rarely causes side effects. It is almost non-toxic, therefore it is indicated for the treatment of pregnant women. The number of contraindications is minimal.
Instructions for use
The drug belongs to the group of tetraenes. Its main property is aimed at the destruction of a fungal infection. Nearly all known pathogenic organisms of similar origin fall under its spectrum of action. Like Pimafucin tablets, reviews of which are advisory in nature, Natamycin is prescribed by a doctor.
The main active ingredient is natamycin. It is obtained by production with an actinomycete. The drug breaks the membrane cells of the pathogenic flora of yeast and similar fungi, dermatomycetes and Trichomonas. Gram-positive cells show resistance to this medication.
"Natamycin" is produced by Russian, European and Asian pharmaceutical companies. The antibiotic is sensitive to sunlight, so it is packaged in a dark opaque container. The active substance natamycin is insoluble in water. It is produced in the form of a powder, which has a yellowish or white color. It dissolves in acetic acid, cooled to the lowest possible temperature, and in dimethylformamide.
If necessary, natamycin can be diluted with methyl alcohol. Like the Pimafucin tablets, the instructions and patient reviews confirm this, it does not have a systemic effect on the body. The substance is not absorbed from the gastrointestinal tract and from the surface of the skin. "Natamycin" is not prescribed to patients who suffer from tuberculosis. The use of the drug should be avoided by persons with individual intolerance to medicinal components.
Side effects of "Natamycin"
Doctors note the presence of adverse effects that may be associated with the use of the drug:
- diarrhea of varying severity;
- vomit;
- nausea;
- burning;
- dryness.
There are no facts of overdose. Itravaginal suppositories are sold in pharmacies without a prescription. In other cases, pharmacists are asked to present the prescription of the attending physician. The cost of "Natamycin", produced in the form of a cream, is 260 rubles. Candles are sold at a price of 250 rubles. The oral form will cost 470 rubles. It is prescribed not only for women, but also for men.
Treatment of thrush
Modern medicine has a wide range of drugs intended for the treatment of fungal infections. In addition to analogues of "Pimafucin", pharmacological companies offer preparations based on fluconazole:
- "Flucostat";
- "Fluconazole-Teva";
- "Fluconazole-OBL";
- "Fluconazole-Stada";
- "Diflucan";
- "Mycosist";
- "Diflazon".
This active ingredient is also contained by "Vagisept" and "Safocid".
"Flucostat"
The capsules are produced by the Russian pharmaceutical company Pharmstandard. Minimum packing - 1 piece. Available in packs of two and seven capsules. The minimum cost is 200 rubles. For seven capsules they ask for 360 rubles. The main component of the drug is fluconazole. Its weight in the composition of the Flucostat capsules is 50 mg. Excipients:
- sodium lauryl sulfate;
- lactose;
- refined corn starch;
- magnesium stearate;
- aerosil;
- gelatin;
- food coloring;
- acetic acid;
- titanium dioxide.
Side effects of Flucostat
While taking the medicine, patients may experience the following pathological conditions:
- headache in different localization;
- convulsions;
- dizziness;
- nausea;
- leukopenia;
- trembling of the ventricles of the heart;
- thrombocytopenia;
- agranulocytosis;
- skin rash;
- anaphylactic shock;
- alopecia;
- erythema;
- necrolysis;
- violation of the urinary system.
Basic information about Flucostat
The drug is sold in pharmacies without a prescription. It is prescribed for the treatment of cryptococcosis and candidiasis. Also used to prevent bacterial infection in AIDS patients. The tool has a lot of contraindications:
- kidney failure;
- hepatic dysfunction;
- combined reception with homeopathic preparations;
- alcohol addiction;
- organic disease remedies;
- pathological changes in electrolyte balance.
"Fluconazole"
This drug is produced by many international and Russian pharmaceutical companies. Estimated price is 280 rubles. It contains 50 mg of fluconazole. The active substance is excreted in a volume of 80%. The drug is sold in the pharmacy network upon presentation of a prescription.
Indications:
- cryptococcal meningitis;
- mycosis of the epidermis;
- candidiasis of various origins.
Contraindications:
- children under 16;
- individual intolerance;
- lactation;
- taking cisapride;
- lactase deficiency;
- the use of terfenadine;
- congenital heart disorders.
"Diflucan"
This drug is produced by the world famous French company Pfizer. This is also an effective antifungal agent, which is aimed at treating thrush. The main component is fluconazole. Packages may contain 12, 7 or 4 capsules.
"Mikosist"
The medicine is sold in cardboard packs. They contain 4 capsules. The manufacturer is the Russian branch of the Gedeon Richter concern. Estimated cost - 730 rubles. The preparation contains 150 mg of the active substance. It is released according to the prescription of the attending physician.
Indications:
- cryptococcosis;
- candidiasis;
- fungal infections.
- Contraindications:
- lactation;
- the use of astemizole;
- lactose deficiency.
"Diflazon"
This prescription drug is manufactured by Vector-Pharm LLC, which is based in Slovenia. Produced in glass bottles with a capacity of 100 ml. The recommended storage temperature is 20°C. An effective antifungal drug is intended for infusion. As auxiliary substances, an aqueous solution of sodium chloride is used.
Side effects:
- headache;
- convulsions;
- neutropenia;
- violations of cardiac activity;
- swelling of the face;
- skin rash;
- necrolysis.
"Vagisept"
The drug contains fluconazole and metronidazole. The medicine is produced in Russia by Firn-M. The drug is dispensed by prescription. Estimated cost is 350 rubles. The cardboard box contains ten vaginal suppositories.
"Safocide"
A package of 12 tablets of the drug is sold at a price of 1681 rubles. Producer - JSC "Nizhpharm" (Russia). There are Indian counterparts. In addition to fluconazole, the drug contains the antibiotic azithromycin, secnidazole.
Since "Safocid" is a set of individual tablets, the set of ingredients for each is different.
Indications:
- various infections of the genitourinary system;
- trichomoniasis;
- urethritis;
- cervicitis;
- gonorrhea;
- vaginosis of bacterial origin;
- cystitis;
- inflammation of the tissues of the vulva;
- vaginitis.
Pimafucin is a drug aimed at eliminating fungal diseases. Its chemical composition is dominated by natamycin, an antibiotic from the macrolide group. This active substance paralyzes the cell membranes of pathogenic fungi, thereby suppressing their activity, and when the dose is increased, it completely destroys the pathogenic environment of the body.
Such types of fungi as Candida, as well as Trichomonas are especially sensitive to this antibiotic. However, it is fair to note here that pathogens such as trichophytosis, mycospores, as well as torulopsis, aspergillus, may be less susceptible to the effects of this drug. Pimafucin is not absorbed from the gastrointestinal tract, skin and mucous membranes.
Due to the wide spectrum of action, this medication is produced in various pharmacological versions, in particular, in the form of Pimafucin cream, suspension for external use, vaginal suppositories and tablets. The acceptable form of release depends on the specifics of the disease, and a detailed annotation to the drug describes the options for its use in all therapeutic combinations.
Of the analogues of Pimafucin, Natamycin, Primafungin and Terzhinan can be noted.
Pimafucin: Indications and contraindications for the use of the drug
It is important to note that Pimafucin is indicated exclusively for the treatment of fungal infections of various origins and areas of localization, in particular, integumentary tissues and mucous membranes, internal organs. The medication is prescribed to eliminate diseases such as otomycosis, vulvitis, vulvovaginitis, intestinal candidiasis.
The good news is that this antibiotic is very often included in the treatment regimen during pregnancy and lactation, and the list of contraindications is limited solely by individual intolerance to the individual components of Pimafucin.
Pimafucin side effects and overdose
Cases of overdose have not been found, however, side effects may worsen during treatment, but mainly at an early stage of administration. Nausea, diarrhea and skin rashes are possible, in the case of using vaginal suppositories or cream, a slight burning sensation upon contact with Pimafucin is also not excluded.
Instructions for use of the drug Pimafucin
The appointment of Pimafucin should be carried out exclusively by the attending physician, since it contains an antibiotic. In addition, the treatment course and daily dosage can vary significantly depending on the nature of the pathology, the degree of its neglect and the characteristics of the patient's body. The detailed instructions for Pimafucin indicate all treatment options with a detailed description of the use of the drug.
Features of the use of the drug Pimafucin
With an increase in body temperature, vaginal suppositories quickly dissolve, forming a homogeneous mass, which evenly spreads over the affected area. If the disease has been modified into a chronic stage, then the use of Pimafucin alone will not be enough for a speedy recovery, therefore, other antibacterial drugs are additionally introduced into the complex treatment regimen.
During menstruation, the introduction of Pimafucin vaginal suppositories must be temporarily suspended. In addition, it is important to understand that such treatment requires a complete rejection of sexual intercourse, and if an infection is detected in a sexual partner, intensive care should concern both.
Reviews about the drug Pimafucin
If we talk about the effectiveness of this drug, then, to be honest, it raises significant doubts, since in most clinical cases Pimafucin in any performance demonstrates a mediocre result, and is not able to completely eliminate the characteristic disease.
It so happens that most of the reviews about Pimafucin, regarding its action in the body, are left by future mothers who are recommended for the treatment of thrush. Almost no one managed to cure candidiasis completely, so many women arbitrarily stopped such treatment, turning to alternative medicine recipes.
Some doctors have stopped prescribing Pimafucin, considering it an obsolete and useless drug, but they still recommend it during pregnancy, since it does not have a pathological effect on the fetus.
In general, the reviews for Pimafucin are negative, and this drug cannot be considered a panacea for fungal infections, and when prescribing it, you need to think again whether it is worth wasting time and spending money on such therapy.
The price of Pimafucin cream 30.0 2% from 230 rubles.
11:27 Pimafucin: instructions, application, reviews -
Fungal infections are a common occurrence in modern medicine today. Characteristic diseases should be eliminated immediately, otherwise the disease may become chronic, requiring long-term treatment. That is why in every pharmacy you can find a huge range of antifungal agents, the action of which is aimed at the destruction of pathogenic microbes. Let us dwell on one of them - Pimafucin. General description of the drug Pimafucin Pimafucin [...]
Tradename:
Pimafucin ®
International non-proprietary name:
Natamycin
Dosage form:
enteric-coated tablets.
Compound:
1 tablet contains: Active substance: natamycin 100.0 mg; Excipients: potato starch 79.2 mg, povidone K30 5.0 mg, magnesium stearate 2.5 mg, lactose monohydrate 66 mg; shell: cellacephate 18 mg, triacetin 2.7 mg, sucrose 122 mg, methyl parahydroxybenzoate 0.07 mg, calcium carbonate 30 mg, kaolin 14.2 mg, talc 21.7 mg, titanium dioxide 3 mg, acacia gum 7.3 mg, gelatin 3.3 mg, white beeswax 0.13 mg.
Description
Round, white or almost white film-coated tablets.
Pharmacotherapeutic group:
antifungal agent.
ATX code: A07AA03
Pharmacological properties
Pharmacodynamics
Antifungal polyene (tetraene) antibiotic of the macrolide group. It has a predominantly fungicidal effect. Natamycin binds irreversibly to the ergosterol of the cell membrane of the fungal cell, which leads to a violation of its integrity, loss of cytoplasmic content and cell death.
Most pathogenic yeasts and molds are sensitive to natamycin, including childbirth. Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Dermatophytes and P. boydii are less sensitive to natamycin. There were no cases of resistance to natamycin in clinical practice. Natamycin in the dosage form of enteric tablets acts only in the intestinal lumen.
Pharmacokinetics
Natamycin is not absorbed from the gastrointestinal tract and has no systemic effect.
Indications for use
- intestinal candidiasis;
- acute pseudomembranous and acute atrophic candidiasis in patients with cachexia, immune deficiency, as well as after antibiotic therapy, corticosteroids, cytostatics;
- sanitation of the intestinal reservoir of fungi of the genus Candida with candidiasis of the skin and mucous membranes, incl. with candidal vaginitis, vulvitis, vulvovaginitis.
Contraindications
Hypersensitivity to the components of the drug.
Dosage regimen and route of administration
inside. Eating does not affect the effectiveness of the drug.
With persistent vaginitis caused by fungi of the genus Candida, together with local antifungal drugs (for example, Pimafucin ® suppositories), Pimafucin ® tablets are used to sanitize the focus of candidal infection in the intestine (orally, 1 tablet 4 times a day for 10-20 days).
The duration of the course of treatment is set individually. After the disappearance of the symptoms of the disease, it is recommended to continue treatment for a few more days.
Precautions for use
Patients with rare congenital intolerance to galactose, fructose, Lapp lactase deficiency, glucose-galactose malabsorption or sucrase-isomaltase deficiency should take into account that the drug contains lactose monohydrate (66 mg) and sucrose (122 mg).
If you have one of the listed diseases, be sure to consult your doctor before taking Pimafucin ®.
Pimafucin ® in this dosage form is not recommended for use in infants due to possible difficulty in swallowing tablets.
drug overdose
No cases of overdose of the drug Pimafucin ® have been reported.
Side effect
On the part of the digestive system: nausea and diarrhea are possible, which occur in the first days of taking the tablets and pass on their own during treatment. If any of the side effects listed in the instructions get worse, or if you notice any other side effects not listed in the instructions, tell your doctor.
Interaction with other drugs
The interaction of the drug Pimafucin ® with other drugs was not found.
Pregnancy and lactation
The use of the drug Pimafucin ® during pregnancy and lactation is possible.
Influence on the ability to drive vehicles and mechanisms
Pimafucin ® does not affect the ability to drive vehicles and mechanisms.
Release form
Enteric-coated tablets 100 mg. 20 tablets in a brown glass bottle with a metal screw cap. 1 bottle in a cardboard box along with instructions for use.
Best before date
4 years. Do not use after the expiry date stated on the packaging.
Storage conditions
Store at a temperature not exceeding 25 °C. Keep out of the reach of children.
Terms of dispensing from pharmacies
Over the counter.
Registration certificate holder
LEO Pharma A/S, Denmark Industriparken 55, DK - 2750 Ballerup, Denmark