The use of the drug Kvamatel - comparison with analogues. Instructions for use How can I replace Kvamatel injections

International name

Famotidine (Famotidine)

Group affiliation

H2-histamine receptor blocker

Dosage form

Lyophilisate for solution for intravenous administration, tablets, coated tablets

pharmachologic effect

Blocker of H2-histamine receptors III generation. Suppresses basal and stimulated by histamine, gastrin and acetylcholine production of HCl. Simultaneously with a decrease in HCl production and an increase in pH, pepsin activity also decreases.

Strengthens the protective mechanisms of the gastric mucosa by increasing the formation of gastric mucus and the content of glycoproteins in it, as well as stimulating the secretion of bicarbonate and endogenous synthesis of Pg in it, promotes the healing of its damage (including scarring of stress ulcers) and the cessation of gastrointestinal bleeding . Weakly inhibits the cytochrome P450 oxidase system in the liver.

After oral administration, the effect begins after 1 hour, reaches a maximum within 3 hours and lasts, depending on the dose, from 12 to 24 hours. Under conditions of intravenous administration, the maximum effect develops after 30 minutes. A single dose (10 and 20 mg) suppresses secretion for 10-12 hours.

Indications

Peptic ulcer of the stomach and duodenum, hyperacidity of gastric juice, heartburn (associated with hyperchlorhydria), symptomatic and stress ulcers of the gastrointestinal tract, erosive reflux esophagitis, NSAID gastropathy, Zollinger-Ellison syndrome, systemic mastocytosis, polyendocrine adenomatosis, prevention of recurrent bleeding in postoperative period.

Prevention of aspiration of gastric juice in patients undergoing operations under general anesthesia (Mendelssohn's syndrome).

Aspiration pneumonitis (prevention).

Dyspepsia with epigastric or retrosternal pains that occur at night or associated with eating.

Contraindications

Hypersensitivity, pregnancy, lactation. With caution. Hepatic and / or renal failure, cirrhosis of the liver with portosystemic encephalopathy (history), childhood.

Side effects

On the part of the digestive system: dry mouth, loss of appetite, nausea, vomiting, abdominal pain, increased activity of "liver" transaminases, hepatocellular, cholestatic or mixed hepatitis, acute pancreatitis.

On the part of the hematopoietic organs: leukopenia, thrombocytopenia, agranulocytosis, pancytopenia, hypoplasia, bone marrow aplasia.

Allergic reactions: urticaria, skin rash, itching, bronchospasm, angioedema, anaphylactic shock.

From the side of the CCC: a decrease in blood pressure, bradycardia, AV blockade, with parenteral administration - asystole.

From the nervous system: headache, dizziness, confusion, hallucinations.

From the senses: blurred vision, paresis of accommodation, ringing in the ears.

From the genitourinary system: with prolonged use of large doses - hyperprolactinemia, gynecomastia, amenorrhea, decreased libido.

From the musculoskeletal system: arthralgia, myalgia.

Local reactions: irritation at the injection site.

Other: dry skin.

Application and dosage

Inside, with exacerbations of gastric ulcer and 12 duodenal ulcer - 0.04 g 1 time per day at bedtime or 0.02 g 2 times a day. If necessary, the daily dose can be increased to 0.08-0.16 g. The duration of treatment is 4-8 weeks.

For the prevention of exacerbations of peptic ulcer - 0.02 g 1 time per day at bedtime.

With Zollinger-Ellison syndrome - at an initial dose of 0.02-0.04 g 4 times a day; if necessary, the daily dose can be increased to 0.24-0.48 g.

With reflux esophagitis, the initial dose is 0.02 g 2 times / day for up to 6 weeks (if necessary, 20-40 mg 2 times a day for up to 12 weeks).

To prevent aspiration of gastric contents - 0.04 g on the eve of surgery or in the morning on the day of surgery, or 0.02 g intravenously, 2 hours before surgery.

Patients with CC below 30 ml / min or with a serum creatinine concentration of more than 3 mg / 100 ml are recommended to reduce the daily dose to 0.02 g.

Children: with gastroesophageal reflux - orally, 1-2 mg / kg / day for children weighing more than 10 kg in 2 divided doses, with body weight less than 10 kg - in 3 divided doses.

In / in slowly, over 2 minutes (gastric bleeding or inability to ingest) with gastric ulcer and duodenal ulcer, hypersecretory conditions of the stomach - 0.02 g every 12 hours; for the prevention of aspiration pneumonitis - intramuscularly, 0.02 g at bedtime on the eve or in the morning on the day of the surgical operation. Powder for injection is diluted in 5-10 ml of 0.9% NaCl (solvent ampoule).

special instructions

May mask the symptoms associated with gastric carcinoma, therefore, before starting treatment, it is necessary to exclude the presence of a malignant neoplasm. Famotidine, like all H2-histamine receptor blockers, is discontinued gradually due to the risk of rebound syndrome with abrupt withdrawal.

With prolonged treatment in debilitated patients, as well as stress, bacterial lesions of the stomach are possible, followed by the spread of infection.

H2-histamine receptor blockers should be taken 2 hours after taking itraconazole or ketoconazole to avoid a significant decrease in their absorption.

H2-histamine receptor blockers can counteract the effect of pentagastrin and histamine on the acid-forming function of the stomach, therefore, within the 24 hours preceding the test, the use of H2-histamine receptor blockers is not recommended.

Blockers of H2-histamine receptors can suppress the skin reaction to histamine, thus leading to. to false negative results (it is recommended to discontinue the use of H2-histamine receptor blockers before conducting diagnostic skin tests to detect an allergic skin reaction of an immediate type).

During treatment, you should avoid eating food, drinks, and other drugs that can cause irritation of the gastric mucosa.

Interaction

It inhibits the metabolism in the liver of phenazone, aminophenazone, diazepam, hexobarbital, propranolol, lidocaine, phenytoin, aminophylline, theophylline, indirect anticoagulants, tricyclic antidepressants, glipizide, buformin, metoprolol, metronidazole, caffeine, BMKK.

Increases the absorption of amoxicillin and clavulanic acid.

Compatible with 0.18 and 0.9% NaCl solution, 4 and 5% dextrose solution, 4.2% sodium bicarbonate solution.

Antacids and sucralfate slow absorption.

Reduces the absorption of itraconazole and ketoconazole.

Drugs that depress the bone marrow increase the risk of developing neutropenia.

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Do you use Kvamatel as an analogue or vice versa?

Kvamatel is an effective tool for the prevention and pathogenetic treatment of gastrointestinal diseases caused by hypersecretion of gastric juice. It belongs to the group of histamine H2 receptor blockers.

Dosage forms and active substance Kvamatel

The drug is available in tablets (for oral administration), and in the form of a lyophilisate for the preparation of a solution for parenteral administration.

The active ingredient in this drug is famotidine.. In 1 tab. contains 20 or 40 mg of the substance. Milk sugar is included as one of the auxiliary ingredients. In 1 vial of lyophilizate (72.8 mg) - 20 mg of famotidine.

Tablets are packaged in foil and PVC blisters of 14 pieces.

The lyophilisate is sold in polymer packs of 5 vials. The package includes 5 ampoules with a solvent (0.9% solution of sodium chloride).

Pharmacological properties

Famotidine blocks the H2 receptors of parietal cells, which slows down the biosynthesis and release of hydrochloric acid. As a result of an increase in the pH of the medium, the activity of the main proteolytic enzyme, pepsin, decreases, and, as a result, the digestive capacity of gastric juice decreases. Secretion of HCl is reduced regardless of the nature of the irritating factor.

By After oral administration of the tablets, the therapeutic effect begins in about an hour. The duration of action is dose-dependent; it ranges from 12 to 24 hours. Absorption in the digestive tract is incomplete. The highest plasma concentrations are recorded after 1-23 hours, and the degree of bioavailability is up to 45%. From 10% to 20% of the active substance is conjugated with blood albumins. Famotidine is able to penetrate the hematoplacental barrier and is excreted in breast milk. The process of biotransformation takes place in the liver; the effect on microsomal oxidation enzymes is very small. The unchanged component and its metabolites are excreted mainly by the kidneys. The half-life varies from 2.3 to 3.5 hours.

Indications for use Kvamatel

• , caused by a hyperacid state;
• erosion of the esophagus;
• and 12 duodenal ulcer (various etiology);
• Zollinger-Ellison syndrome (a symptom complex that occurs with gastrin-producing neoplasms).

The drug is also prescribed to prevent gastric aspiration during operations under general anesthesia and to prevent mucosal ulceration while taking NSAIDs and corticosteroids.

Contraindications

Kvamatel is contraindicated in case of intolerance to famotidine, auxiliary ingredients and hypersensitivity to other drugs from the group of H2 receptor blockers.

The tablets contain lactose monohydrate, so you can not take them with.

Dosing regimen

At relapses orally take 20 mg 2 r / day or 40 mg in the evening before bedtime. If indicated, the daily dosage may be increased to 160 mg. The duration of course therapy is determined by a gastroenterologist, taking into account the severity of symptoms and the dynamics of the process. It usually takes 4 to 8 weeks.

At gastric contents into the esophagus drink 20 mg 2 r / day. If necessary, the dose is increased by 2 times.

For prevention of exacerbations of peptic ulcer disease It is recommended to take 20 mg at bedtime.

Treatment Zollinger-Ellison syndrome involves the use of high doses; at the initial stage of therapy, 20-40 mg are taken 4 times a day, maintaining 6-hour time intervals. The maximum daily dose can be up to 480 mg.

Patients who are to operation under anesthesia , give 40 mg in the evening on the eve of surgery and 2.5 hours before general anesthesia in order to prevent aspiration of gastric juice. The dose for intravenous administration is half as much.

Parenterally, Kvamatel is prescribed only if it is impossible to receive per os. For intravenous jet or drip administration, the lyophilisate is diluted in 5-10 ml of solvent (1-2 ampoules) immediately before injection or infusion. The finished product can be stored at room temperature for no more than 24 hours; then it loses stability. The solution is injected by jet for ≥ 2 minutes, and drip - 15-30 minutes.

The usual single dose is 20 mg, and the frequency of administration is 2 r / day with 12-hour intervals. With diagnosed Zollinger-Ellison syndrome, injections are made 4 r / day.

Side effects of Kvamatel

With hypersensitivity to famotidine, allergic reactions are not excluded.

In rare cases, after the use of Kvamatel, the following symptoms appear:

• ( , );
• general weakness;
• rapid physical fatigue;
• disturbances of consciousness and hallucinations (in debilitated patients);
• slow heart rate;
• atrioventricular block;
• transient blurred vision;
• joint and muscle pain;
• decrease in sexual desire;
• feverish reaction;
• an increase in the concentration of prolactin in the blood.

Overdose

With a significant excess of the recommended dosages, trembling of the extremities, hyperkinesia, arterial hypotension and increased heart rate may occur. The development of a collaptoid state is not excluded.

In case of an overdose, the victim must wash the stomach and give it for the speedy removal of drug residues from the body. In a severe general condition, hospitalization and hardware blood purification (hemodialysis) are required.

Interaction of Kvamatel with pharmacological agents

As a result of a decrease in the acidity of the stomach, the absorption of antifungal drugs, Itraconazole and Ketoconazole, slows down.

Parallel use of Kvamatel with immunosuppressants increases the likelihood of developing neutropenia.

The antiulcer agent increases the absorption of amoxicillin and clavulanic acid.

The bioavailability of famotidine tends to decrease with the use of antacids.

Kvamatel during pregnancy and breastfeeding

There are no data from clinical studies that clearly indicate the safety of famotidine for the fetus and infant. For this reason, it is contraindicated for patients during gestation. If it is necessary to conduct course therapy during lactation, it is necessary to transfer the baby to artificial feeding.

Additional instructions

It is important to take special care when prescribing drugs to patients with functional liver failure (against the background, etc.) or with hepatic encephalopathy (including history). Often, a reduction in the daily dose to 20 mg or an increase in the interval between doses up to one and a half days is required. The criterion for the need for dosage adjustment is the serum creatinine concentration.

You should not abruptly stop taking; it is advisable to gradually reduce the dose to avoid the appearance of a withdrawal syndrome.

At the time of therapy, you should refrain from drinking alcoholic beverages and foods that cause hypersecretion of hydrochloric acid.

Rules for storage and sale through pharmacy chains

A prescription is required to purchase Kvamatel, which is on the list of potent drugs.

Blisters and ampoules are stored in a dark place at a temperature not exceeding +25°C.

The shelf life of tablets, subject to storage rules, is 5 years from the date of issue, and the lyophilisate is 3 years. The solvent is good for 5 years.

Kvamatel tablets - RLS, which is used in gastroenterology. It is not possible to buy it yourself. To purchase, the patient must obtain a prescription from a doctor, and read the instructions before use.

Leaflet

The drug Kvamatel is prescribed to the patient in different forms: pills and lyophilisate for injection. A medical prescription must indicate which form of release the consumer needs:

• tablets Kvamatel MINI - contain 10 mg of active ingredient;
• Kvamatel 20 (tablets) - contains 20 mg of the active ingredient;
• Kvamatel 40 - contain, respectively, 40 mg of the drug;
• Ampoules Kvamatel - 20 mg in each vial.

The active substance of the drug is famotidine. It contributes to the blocking of histamine receptors located on the surface of the mucous membrane of the stomach and intestines. Thus, the drug Kvamatel reduces the release of hydrochloric acid, which disrupts digestion and damages the walls of the gastric tract. The generic drug famotidine also reduces the negative effects of pepsin.

The drug is also prescribed because it does not affect the motility of the stomach. The natural work of the stomach allows you to move food to the intestines in time. Treatment helps to reduce acidity, while not affecting the enzymes of the pancreas, liver and human hormones.

Indications and contraindications

Guidance for the use of Kvamatel must be obtained from a specialist. After the examination, the doctor will select an individual dosage for the patient and talk about the features of the drug. Each potential consumer needs to study the leaflet that is attached to the Kvamatel. Instructions for use describes the following indications for use:

• ulcerative lesions of the stomach or intestines (in the acute stage), prevention;
• erosive gastroduodenitis;
• refluxes;
• Zollinger-Ellison or Mendelssohn syndromes;
• prevention of bleeding from the upper parts of the digestive system;
• dyspeptic disorders arising from high acidity.

The person taking the medicine should be well examined. Doctors do not prescribe drugs of this group to the following patients:

• having hypersensitivity or allergy to the components of the drug;
• women throughout the gestation period and during lactation;
• children of all ages.

Patients with pathologies of the liver and kidneys should be given special attention and it is better to monitor the reaction of their body to the use of tablets or the introduction of a solution.

Usage

The international name of the drug (famotidine), prescribed in the instructions in Latin, has its own application features:

1. before starting use, it is better to undergo a complete examination, since a pharmacy can give a blurred clinical picture of many dangerous diseases;
2. it is unacceptable to abruptly cancel the medication - it is necessary to take smaller doses, and then stop using it altogether;
3. it is unacceptable to combine famotidine with antifungal drugs and antacids, you need to take a break of at least 2 hours;
4. during the period of treatment it is necessary to follow a diet;
5. with pathologies of the liver and kidneys, the volume of the prescribed medication should be reduced.

Pills

Kvamatel tablets instructions for use recommend drinking 1 to 4 times a day. The volume and frequency of consumption of famotidine depends on the severity and nature of the pathology. For each patient, it is advisable to choose an individual treatment regimen.

Table of generally accepted schemes for the use of tablets.

Disease	The amount of the drug	Duration of admission
Aggravated ulcer	40 mg in the evening once or 20 mg 2 times with the same break; maximum volume - 160 mg	1 to 2 months
Ulcer prevention	20 mg at bedtime	Not more than a month
Esophagitis reflux	20 mg in the morning and evening (sometimes it is acceptable to use double-volume tablets)	For 6 weeks
Zollinger-Ellison Syndrome	40 mg up to 4 applications per day; maximum dose 480 mg	According to the forecast
Prevention of Mendelssohn's syndrome	40 mg before anesthesia (1 or 2 hours before)	once
Dyspeptic disorders caused by high acidity	10 mg 1-2 times a day; maximum dose per day 20 mg	Not longer than 14 days

Important! The drug can affect the rate of psychomotor reactions, therefore, during the period of administration, care must be taken not to exceed the dose prescribed by the doctor.

Injections

Kvamatel intravenously is prescribed in exceptional cases, when you can not hesitate and there is no way to take pills. Intramuscular administration is not allowed. The ampoules contain a white powder. Before use, you need to prepare a solution. For this, sodium chloride is used (up to 10 ml).

It is unacceptable to interfere with a solution of lidocaine, novocaine or other injection liquids. It is preferable to administer the medication by drip, but injections into a vein are allowed. The solution is injected slowly, at least 2 minutes. Depending on the severity of the pathology, doctors choose a certain dose of famotidine:

• 20 mg once used to prevent Mendelssohn's syndrome (not earlier than 2 hours before surgery);
• 20 mg 1-2 times is administered with exacerbated manifestations of an ulcer (the break should be exactly 8 hours);
• 20 mg with quadruple application for the treatment of Zollinger-Ellison syndrome.

The solution for injection helps in critical situations when emergency intervention in the digestive tract is necessary. Subsequently, the patient is transferred to the oral administration of the drug.

Important! Injections are used exclusively in medical institutions, staging an injection on your own is unacceptable.

Unpleasant reactions

For the drug Kvamatel, the use must strictly comply with the medical prescription. You can not independently adjust the dose of the drug or change the regimen. It should be remembered that, like any analogue of Kvamatel, the claimed remedy has a chance of causing side effects:

• vascular disorders - bradycardia, arrhythmia, pressure surges;
• digestive abnormalities - loss of appetite, abdominal pain, liver pathology;
• neurological manifestations - apathy, fatigue, drowsiness;
• disturbances in the work of the hematopoietic system;
• allergic and dermatological side effects;
• fever, muscle pain, hearing loss.

If adverse reactions occur, the patient should receive medical attention as soon as possible. After eliminating the negative effects, the specialist selects suitable analogues and substitutes that will not provoke such a reaction.

Analogues and generics

The drug Kvamatel has structural and relative analogues. The former completely replace the drug, as they contain the same active ingredient. Relative analogues have similar indications for use, but work on the basis of a different active ingredient.

Structural substitutes:

• Famotidine;
• Gastrocidin;
• Famosan;
• Ulfamid.

If for some reason Kvamatel is not suitable for the consumer, the analogue is selected with another active component:

• Ranitidine;
• Zantac;
• Gistak;
• Cimetidine.

Conclusion

With the prescription product Kvamatel, adverse reactions are rare, but they are not excluded. In order for the treatment to bring maximum benefit, it is necessary to undergo an examination and receive an appointment from a specialist before using the drug.

Independent use of tablets and injections is dangerous, it can lead to unexpected reactions of the body. If there is no positive effect within a few days of using the tablets, contact a gastroenterologist.

There are many diseases of the stomach. Among them are gastritis, peptic ulcer, bleeding, heartburn caused by high acidity in the stomach, and many others. For their treatment, many doctors prescribe a drug such as Kvamatel, as well as any analogues of Kvamatel, which are similar to it in their action. Among them are drugs such as gastrosidin, famatel, famotidine and many others.

Kvamatel or Omez

There are both similarities and differences between these drugs. Consider the features of the action of and and omez and the result of their application.

Kvamatel- a drug that appeared on the drug market a long time ago, but still has not lost its popularity in the treatment of certain diseases of the stomach. Many doctors continue to prescribe it, and the treatment of patients is very effective. It can be taken in the form of tablets or in the form of injections, which allows doctors to develop an individual treatment method for each patient. Many studies have been conducted on this drug, on the basis of which it can be concluded that when used in the treatment of complex therapy, Kvamatel can accelerate recovery by 10%.

Already in the first week of treatment, a positive effect is observed. Reduces the need for painkillers. This medicine is often used for acute and chronic pancreatitis, the course of treatment of which is from one to one and a half months. The use of such an analogue of Kvamatel as gastrocepin together with Kvamatel itself relieves pain in the first days of an attack of the disease.

Omez also included in the analogues of Kvamatel and is prescribed to many patients. This drug is aimed, rather, not at relieving pain, but at providing maximum rest to the pancreas. Having an effect on the gastric mucosa, omez prevents the formation of hydrochloric acid and reduces the increased acidity of gastric juice. This remedy is very common in diseases such as pancreatitis, Zollinger-Ellison syndrome, in diseases of the duodenum and many other diseases. The drug is contraindicated in pregnant women, children, people with liver and kidney disease. Doctors do not prescribe Kvamatel and Omez to patients if an individual intolerance to the drugs is detected.

Kvamatel is an effective drug for the treatment of pathologies of the upper gastrointestinal tract. The clinical action is to reduce the concentration and amount of gastric juice, the regulation of pepsin synthesis.

The drug selectively blocks histamine H2 receptors. Reduces basal and stimulated production of gastric juice, the concentration of hydrochloric acid and pepsin. The apparent therapeutic effect of Kvamatel begins after 1 hour and lasts for 10-12 hours.

Additionally, Kvamatel increases the formation of gastric mucus and the content of glycoproteins in it, which enhances the protection of the stomach from irritants. Increases the production of bicarbonate and endogenous synthesis of prostaglandins, accelerates the tightening of damage to the gastric mucosa, incl. scarring of ulcerative lesions and stopping bleeding of the gastrointestinal tract.

Significantly without affecting gastrin parameters after meals or on an empty stomach, Kvamatel does not “slow down” gastric motility, exocrine activity of the pancreas, blood supply in the portal system, hormone levels, and does not have an antiandrogenic effect.

The half-life of the active substance of the drug is approximately 3 hours. The main part is excreted from the body unchanged in the urine.
The use of Kvamatel for heartburn and gastralgia (provoked by increased acidity of gastric juice) has received many positive reviews from doctors and patients, but this is not the only prescription for the drug.

In acute pancreatitis and exacerbation of chronic pancreatitis, urgent therapy is often started with an intravenous drip of Kvamatel, and after the patient's condition improves, they switch to taking pills.

Indications for use Kvamatel

1. Peptic ulcer of the stomach and duodenum;
2. Functional dyspepsia associated with increased secretory function of the stomach;
3. Erosive gastroduodenitis;
4. Reflux esophagitis;
5. Prevention of recurrent bleeding from the upper gastrointestinal tract (GIT);
6. Zollinger-Ellison syndrome;
7. Prevention of aspiration of gastric juice in patients undergoing operations under general anesthesia (Mendelssohn's syndrome);
8. Bleeding from the upper gastrointestinal tract (as part of complex treatment).

Instructions for use Kvamatel, dosage

Instructions for use of the drug contains detailed guidance on how to use Kvamatel for treatment and dosage determination.

Kvamatel tablets - instructions for use

With peptic ulcer of the stomach and duodenum in the acute phase, the dosage of Kvamatel is 40 mg 1 time / day at bedtime or 20 mg 2 times / day, morning and evening.

According to diagnostic data, if necessary, the daily dose is increased to 80-160 mg. The duration of the course of therapy is an average of 4-8 weeks.

To prevent exacerbations of gastric and duodenal ulcers, the drug is prescribed at a dosage of 20 mg 1 time / day at bedtime.

With Reflux Esophagitis, the dosage of Kvamatel is 20 mg 2 times / day for a course of 6 weeks, it is possible to increase the dosage to 40 mg.

With Zollinger-Ellison syndrome, the therapeutic dose is 20-40 mg. Every 6 hours. The dosage depends on the condition of the patient. The duration of treatment is determined by the doctor.

To prevent the ingress of gastric juice into the respiratory tract during general anesthesia - the dosage of Kvamatel 40 mg the day before surgery.

Kvamatel in ampoules - instructions for use

Kvamatel is used in/in, jet or drip only in severe cases or when it is impossible to take the drug inside.

Kvamatel in ampoules are used exclusively in a hospital under constant supervision. As the patient's data improves, it is recommended to switch to oral administration (in tablets). The standard dosage is 20 mg 2 times / day (every 12 hours). A single dose should not exceed 20 mg.

For the treatment of Zollinger-Ellison syndrome, the initial dosage is 20 mg every 6 hours, according to symptoms and diagnostic data, the dosage is adjusted depending on the secretion of hydrochloric acid and the patient's condition.

To prevent the penetration of gastric juice into the respiratory tract during general anesthesia - a dosage of 20 mg Kvamatel intravenously the day before surgery.

Preparation of solution for injection

Injections are used exclusively in the hospital and, as soon as possible, the patient is transferred to oral administration of Kvamatel (tablets).

To administer Kvamatel intravenously by drip - dissolve the contents of the ampoule in 100 ml of 5% glucose solution for infusion and slowly inject over 15-30 minutes.

The prepared solution can be stored at room temperature for 24 hours.

Peculiarities

Against the background of kidney or liver dysfunction, the daily dose is reduced to 20 mg.

The maximum single dose of Kvamatel is 20 mg.

The use of Kvamatel in high doses can cause symptoms of an overdose, according to signs of manifestation comparable to side effects.
Treatment with Kvamatel is stopped smoothly, gradually reducing the dose to avoid withdrawal syndrome.

Contraindications Kvamatel

Instructions for use Kvamatel highlights a list of contraindications for use:

• hypersensitivity to famotidine and other blockers of histamine H2 receptors;
• pregnancy and/or lactation;
• childhood.

With caution, Kvamatel should be prescribed for renal and hepatic insufficiency, with cirrhosis of the liver with a history of portosystemic encephalopathy.

Side effects of Kvamatel

• dry mouth, vomiting, abdominal pain, constipation, diarrhea, loss of appetite;
• hepatocellular, cholestatic or mixed hepatitis, acute pancreatitis;
• pancytopenia, leukopenia, thrombocytopenia, hypo- or aplasia of the bone marrow;
• urticaria, skin rash, dry skin, itching, bronchospasm, angioedema, anaphylactic shock;
• arrhythmia, bradycardia, AV blockade, lowering blood pressure;
• headache, dizziness, drowsiness, confusion;
• decreased visual acuity, tinnitus;
• at elevated dosages - hyperprolactinemia, gynecomastia, amenorrhea, decreased libido;
• myalgia, arthralgia, fever.

Kvamatel analogs, list

Analogues of the drug include (list of drugs):

• Famosan,
• famotidine,
• famotidine-acry,
• Ulfamide,
• Gastrocidin,
• Famonite.

It is important to understand that analogues are not a complete copy of the drug - instructions for use of Kvamatel, price and reviews of analogues do not apply and cannot be used as a guide (instruction) in prescribing treatment or dosages. When replacing Kvamatel, it is important to get expert advice.

Terms and conditions of storage
Tablets should be stored at a temperature not exceeding 30 ° C, lyophilizate - 15-25 ° C, in a place protected from light, out of the reach of children.

Best before date:
Tablets and solvent - 5 years; Lyophilisate - 3 years.