"Ribomunil": analogues, price, instructions, description. Ribomunil analogues Ribomunil analogue
Latin name: Ribomunyl
ATX code: L03AX
Active substance: Ribosomal-
proteoglycan complex
Manufacturer: Pierre Fabre Medication
Production, France
Pharmacy leave condition: Over the counter
Price: from 350 to 1050 rubles.
“Ribomunil” (synonymous with Ribomunal granulate) is a unique remedy consisting of a complex of ribosomes, which include pathogens of infectious diseases of the respiratory system. When the drug enters the body, it creates the effect of vaccination, thereby activating the formation of antibodies to these viruses.
According to doctors, this is one of the most effective medicines, thanks to which you can get a stable immune system to many infectious diseases of the ENT organs and the respiratory system.
Indications for use
Reception of "Ribomunil" begins with such indications:
- For the treatment and prevention of infectious ENT diseases (otitis media, laryngitis, tonsillitis, pharyngitis, etc.) in children older than six months
- In the treatment and prevention of infectious pathologies of the respiratory system (bronchitis, pneumonia, infectious bronchial asthma) in children from 6 months
- To prevent ailments in people who often suffer from respiratory and chronic diseases, especially in the autumn-winter period. You can take medicine for all age categories, including people of retirement age and children older than six months.
Compound
"Ribomunil" tablets include in their composition the main active ingredient bacterial ribosomes, titrated to 70% ribonucleic acid. Auxiliary ingredients: magnesium sterart, silicon, sorbitol.
"Ribomunil" granules are intended for solution preparation. Active ingredient: bacterial ribosomes 0.75 mg, additional substances: polyvidone, D-mannitol.
Medicinal properties
The drug is considered to be an immunomodulator of bacterial origin. It consists of a ribosomal-proteoglycan association, which includes a large number of causative agents of colds and respiratory tract infections. "Ribomunil" stimulates the production of antibodies to incoming microorganisms, thereby increasing the defenses and the human immune system.
With complex treatment, the active substance significantly improves the patient's condition, greatly reduces the duration of treatment, reduces the frequency and need for the use of antibiotics and bronchodilators. The medicine can be taken regardless of whether the body temperature is elevated or not.
The average price is from 400 to 1050 rubles.
"Ribomunil", tablets
Tablets are round, convex, white in color, odorless. Available in 0.25 mg and 0.75 mg. Tablets with a dosage of 0.25 mg, 12 pcs. in a blister, 0.75 mg - 4 pcs. in a blister. Sold in packs of cardboard, with attached instructions.
Application methods
"Ribomunil" should be taken once a day before meals, in the morning on an empty stomach, regardless of whether the body temperature is elevated or not. The treatment regimen with "Ribomunil" is the same for adults and children under one year old. A single dose is 0.75 mg of the drug (1 tablet).
In the case of therapy or prophylaxis, it is important to use the drug for 3 weeks, on the first 4 days of each week. Further reception is carried out within 5 months, on the first four days of each month.
Also, in order to prevent the disease, it is better to take “Ribomunil” for 3 months, 2-3 times a year, taking breaks.
The average price is from 350 to 450 rubles.
Granules “Ribomunil”
The granules are white in color, odorless. They are packaged in paper laminated bags of 500 mg of the substance, 4 bags in one package.
Mode of application
In the case of taking the powder, the dosage does not change. One sachet should be poured into a glass of warm water and stirred until completely dissolved. Often, taking granules is more effective for children under one year old.
Contraindications and precautions
The main contraindications for which it is not recommended to take the medication are:
- Autoimmune pathologies
- Intolerance to active ingredients.
When the temperature rises, the symptoms of the disease become more pronounced, you should not stop taking the medication, because doctors say that this is a manifestation of a therapeutic effect.
During pregnancy and breastfeeding
It is forbidden to take medicine when a woman is expecting a baby and breastfeeding. If its use is unavoidable, then the doctor carefully evaluates the ratio of benefit to the woman and the risk to the child.
Cross-drug interactions
The drug is allowed to be taken in combination with drugs such as antibiotics, anti-inflammatory drugs, bronchodilators.
Side effects
While taking the drug, side effects are rare. In patients in the first days of using the drug, hypersalization may occur. Allergies (urticaria, swelling), as well as nausea or vomiting, diarrhea may also occur.
Terms and conditions of storage
"Ribomunil" should be stored in a place closed from children, at a temperature of 15 to 25 degrees.
Analogues
"Bronchomunal". "Bronchomunal" or "Ribomunil", which is better?
Lek d.d., Slovenia / Sandoz, Switzerland
Price from 132 to 1470 rubles.
The drug is an immunostimulating drug of bacterial origin. It is produced in the form of capsules containing a light beige powder. One capsule contains lyophilized bacterial lysate and excipients. Bronchomunal is indicated for respiratory infections and colds, both in a child and in adult patients.
pros
- Effective as a prophylactic
- Can be taken in combination with other drugs
Minuses
- High price
- At reception disturbances from the alimentary system are possible.
Lek, Slovenia
Price from 300 to 350 rubles.
"Immunal" is the best immunostimulating agent, consisting of natural components of plant origin. It is presented by the manufacturer in the form of tablets and solution, which are intended for the prevention and complex treatment of infectious and catarrhal ailments.
pros
- Strengthens the immune system
- natural preparation
- Can be given to children
Minuses
- Possible allergic reaction
- Not recommended for pregnant women and while breastfeeding.
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Now it's impossible to get it! Called all pharmacies and online pharmacies! They answer that he has not been in Russia for a long time at all! Friends are resting in Turkey, she asked me to look, also not! They show them a box (photo), and they answer that they have never had this drug!!! So where do you get it???
Only thanks to Ribomunil we forgot what it is to get sick every month. single bronchitis. Nephew also helped a lot.
Before going to the kindergarten, the pediatrician advised us Ribomunil. You know, a lot of reviews about Ribomunil and re-read. Many praised the drug, some, on the contrary, found fault with it, but as you know, each organism has its own perception of any medication. Ribomunil is a kind of vaccine, and we did all the vaccinations, did not refuse. Started taking... Before going to the kindergarten, the pediatrician advised us Ribomunil. You know, a lot of reviews about Ribomunil and re-read. Many praised the drug, some, on the contrary, found fault with it, but as you know, each organism has its own perception of any medication. Ribomunil is a kind of vaccine, and we did all the vaccinations, did not refuse. Started taking a couple of months before going to the garden. I knew perfectly well that in kindergarten a child would get sick many times while adapting to a new environment. But! For 6 months in the garden, we got sick only once, and that one did without a temperature!!! I think it's an indicator. Therefore, Ribomunil is a very effective and necessary drug!
Thank you
The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!
Ribomunil represents immunomodulator with the properties of a vaccine that creates protection against the most common pathogenic microorganisms that cause various infectious diseases of the respiratory tract and ENT organs. The drug is used to prevent chronic or recurrent infections of the respiratory tract and upper respiratory tract, such as rhinitis, sinusitis, tonsillitis, pharyngitis, bronchitis, pneumonia and bronchial asthma.Ribomunil - dosage, composition and form of release
Currently, Ribomunil is available in two dosage forms - pills And granules to prepare a solution for oral administration. Granules are often called powder, implying the same dosage form of Ribomunil. As an active ingredient, Ribomunil granules and tablets contain pure ribosomes and parts of cell membranes of various pathogenic microorganisms that cause infections of the respiratory tract and ENT organs, such as Klebsiella pneumoniae, Streptococcus pneumoniae, Streptococcus pyogenes And haemophilus influenzae.
Ribosomes are special intracellular structures (organelles) that carry out the synthesis of proteins and are present in every cell of any living creature - both humans, animals, birds, insects, and microbes. But in each species of living beings, ribosomes have certain characteristics and carry species-specific antigens that allow them to be clearly identified. Thus, the ribosomes isolated from microbial cells carry antigens, thanks to which the human immune system can "recognize" the pathogenic microorganism and develop antibodies against it. As an additional substrate that carries microbial antigens, Ribomunil uses particles of cell membranes of the same bacteria, which, in fact, accelerate the production of antibodies.
However, neither a ribosome nor a cell membrane fragment is capable of causing an infectious disease, they can only activate the immune system and force it to produce a large amount of antibodies that will circulate in the blood and protect a person from the possible penetration of a full-fledged microbe. That is, purified ribosomes with membrane particles are a vaccine that is used to develop immunity to infections of the respiratory tract and ENT organs.
Ribomunil tablets are available in two dosages - 250 micrograms and 750 micrograms of ribosome fractions of pathogenic microbes. Usually, the amount of the active ingredient in 250 mcg is indicated as 1/3 of a single dosage, and 750 mcg as 1 dose. This means that for a single dose, a person will need either 3 tablets of 250 micrograms or 1 tablet of 750 micrograms. The amount of cell membranes in tablets with 750 μg of ribosomes is 1.125 mg, and with 250 μg - 0.375 μg. However, only the amount of ribosomal fractions is always used to indicate the dosages of Ribomunil, and the content of cell membranes is not indicated, since this lengthens and complicates speech. Also, for simplicity and clarity, tablets containing 750 μg of ribosomal fractions and 1.125 mg of membrane particles are referred to as 1-dose tablets. And tablets with 250 µg of the ribosomal fraction and 0.375 µg of membrane particles are referred to as tablets with 1/3 dose.
Granules for the preparation of the solution are available in sachets that contain 1 dose of active ingredients, that is, 750 μg of the ribosomal fraction and 1.125 mg of pathogenic microbial cell membranes. Thus, one sachet of granules is equal to 1 tablet of 750 mg.
As auxiliary components, tablets of both dosages contain silicon, magnesium stearate and sorbitol. Ribomunil granules contain povidone, mannitol, silicon, magnesium stearate and sorbitol as auxiliary components.
Tablets with 1/3 dose are available in packs of 12 pieces, and with 1 dose - 4 pieces each. Sachets with granules are packed in boxes of 4 pieces.
Ribomunil - photo
These photographs show the appearance of various packages of Ribomunil.
Therapeutic effects of Ribomunil
Ribomunil is, in fact, a vaccine against microbes, which are most often the causative agents of infectious diseases of the respiratory tract and ENT organs. The action of this vaccine consists of an immunostimulating effect and the direct production of protective antibodies to pathogenic microbes, that is, the effect of vaccination.It is well known that vaccination is the introduction into the human body of weakened but living microbes, or their particles, which cause an immune response with the formation of antibodies. It is these antibodies that have been developed that will protect a person from infection with an infection against which they have been vaccinated for a certain period of time. The duration of the protective effect of vaccination depends on the properties of the microbe-causative agent of the infection.
Since Ribomunil contains various parts of pathogenic microbes that most often cause infections of the respiratory and ENT organs, its intake is a kind of vaccination. After all, particles of bacteria enter the human body, on which protective antibodies are produced. Then, when a real infectious agent enters the body, ready-made, already existing antibodies will be able to destroy it very quickly, since it will no longer be necessary to spend some time to develop them. It is thanks to this mechanism of action that Ribomunil effectively prevents infections of the respiratory and ENT organs.
However, given that antibodies against the causative agents of these infections circulate in the blood for a short time, in order to maintain immunity to them, it is necessary to take a course of Ribomunil periodically (optimally 1 time in 1-2 years).
In addition to the effect of the oral vaccine, Ribomunil has the properties of a non-specific immunity stimulant. Immunostimulation consists in increasing the activity of macrophages, leukocytes and natural killers, which destroy any pathogenic microorganisms that have fallen on the mucous membranes, for example, viruses, chlamydia, prions, etc.
Thus, the cumulative effect of Ribomunil is achieved - it creates immunity to some infectious agents, while others are destroyed by active immunocompetent cells that are constantly present on the mucous membranes. Therefore, the drug effectively prevents both viral and bacterial infections.
Ribomunil can be used both for the purpose of prevention and in the complex treatment of various chronic or protracted infections of the respiratory and ENT organs. The introduction of Ribomunil into the composition of complex therapy makes it possible to reduce the course of antibiotics and bronchodilators, as well as speed up recovery.
Ribomunil - indications for use
Ribomunil is indicated for use in the prevention and treatment of the following chronic infectious and inflammatory diseases of the respiratory and ENT organs in adults, the elderly and children from 6 months of age: - Rhinitis;
- tonsillitis (tonsillitis);
- Pharyngitis;
- Laryngitis;
- Bronchitis;
- Tracheobronchitis;
- Pneumonia;
- Infection-dependent bronchial asthma.
1. Frequently and long-term sick people;
2. The beginning of the cold season;
3. Areas with unfavorable environmental conditions;
4. The presence of chronic diseases of the upper respiratory tract, bronchitis or bronchial asthma.
Ribomunil - instructions for use
General provisions
Ribomunil tablets or granules should be taken at least half an hour before meals once a day, preferably in the morning. In this case, a single dosage for adults and children older than six months is 1 tablet of 750 mg (with 1 dose), granules from one sachet or three tablets of 250 mg (with 1/3 of the dose). That is, once a day, an adult or child should take one 750 mg tablet, or one bag of granules, or three 250 mg tablets.Tablets must be swallowed whole, without chewing or crushing in other ways, with a small amount of water (at least half a glass). Granules from one sachet should be pre-dissolved in half a glass of water at room temperature. After complete dissolution of the granules, it is necessary to drink the resulting solution.
For children under one year old, it is recommended to give Ribomunil exclusively in the form of granules, since at this age it is difficult for them to swallow tablets. Children older than a year and adults need to choose the dosage form that they best tolerate. For example, if the child normally swallows the pills, and this does not cause him any discomfort, and he does not refuse to take the medicine, then this form of the drug can be used. If the child does not know how to swallow tablets, chews them or refuses to take them, then Ribomunil should be given to him in the form of a solution of granules.
Against the background of the use of Ribomunil in an adult or a child, the temperature may rise and last for 2-3 days, which is one of the manifestations of the therapeutic effect that does not require special treatment or discontinuation of the drug. The temperature caused by the action of Ribomunil usually normalizes on its own within 2 to 3 days. In this situation, the use of antipyretic drugs is not recommended if the temperature is tolerated satisfactorily. However, if the temperature is not well tolerated, then you can knock it down by taking drugs based on paracetamol, ibuprofen or nimesulide. Aspirin should not be given to children, under any circumstances, and is not recommended for adults. Aspirin should only be considered as a backup antipyretic drug for adults, which can only be used when paracetamol, ibuprofen and nimesulide have already been taken but have not been effective.
In addition, while taking Ribomunil, mild and mild symptoms of infectious diseases of the respiratory tract and ENT organs may appear, which also do not require treatment and discontinuation of the drug, and pass on their own. Usually, the appearance of these symptoms is combined with an increase in temperature, and simultaneously with its normalization, they completely disappear.
Ribomunil should be used with caution in people with autoimmune disease, periarteritis nodosa or HIV/AIDS.
The drug interaction of Ribomunil has not yet been established. This means that in combination with Ribomunil, various drugs can be used to treat infectious and inflammatory diseases of the respiratory tract and ENT organs, such as antibiotics, bronchodilators (Fenoterol, Salbutamol, etc.), anti-inflammatory and antipyretic drugs (Nimesulide, Ibuprofen, Panadol, etc.).
Ribomunil - regimen for prevention and during illness
For the treatment and prevention of various diseases of the respiratory tract and ENT organs, Ribomunil is taken according to the same scheme.However, if Ribomunil is started during an acute course of a disease of the respiratory tract or ENT organs, then it must be combined with the usual treatment of the infection. Remember that Ribomunil during the period of illness will not replace antibiotics, bronchodilators, expectorants, antipyretics and anti-inflammatory drugs. That is, you will have to take all the necessary treatment and, in addition to it, Ribomunil. If Ribomunil is taken during the period of remission, when the adult or child is healthy, then no additional medications are required.
You can start taking Ribomunil at any time - both during illness, and during the period of recovery or full health.
So, Ribomunil is taken according to the following scheme:
1.
In the first week for four days, for example, from Monday to Thursday inclusive (or from Tuesday to Friday, etc.) take daily once a day, 1 tablet of 750 mcg, or one bag of granules or 3 tablets of 250 mcg;
2.
In the second and third weeks, take the drug in the same way as in the first, starting from the same day. For example, in the first week they started taking Ribomunil on Wednesday and finished on Saturday, which means that in the second and third weeks you should drink the drug on the same days;
3.
Exactly one month later, counting from the first day of taking the drug, you must again take 1 tablet of 750 mcg, or one bag of granules, or 3 tablets of 250 mcg once a day for 4 days. For example, if the first tablet of Ribomunil was taken on May 25, then in a month it will be June 25. So, it is from June 25 that you should start taking 1 dose of Ribomunil once a day for 4 days;
4.
It is necessary to repeat the four-day intake of Ribomunil within five months after the first three weeks of treatment. For example, the first pill was taken on May 25th. For the next three weeks, the drug was used 4 tablets on the first 4 days of each week. Then you should take Ribomunil in one dose (1 tablet 750 mcg, 1 sachet of granules or 3 tablets 250 mcg) once a day for 4 days from the 25th to the 28th of June, July, August, September, October and November. You can halve the course and take Ribomunil only until August inclusive, that is, for three months instead of six.
Ribomunil during pregnancy and lactation
The drug can be used only if the intended benefit to the mother outweighs the possible risks to the fetus. This wording is due to the fact that special studies on the safety of Ribomunil in pregnant and lactating women have not been conducted for obvious ethical reasons. And therefore, its complete safety for pregnant women has not been proven. However, in animal experiments, no negative effect of Ribomunil on the fetus and the course of pregnancy was revealed. Therefore, theoretically, the drug is safe for pregnant women, but since this has not been experimentally proven, Ribomunil is not recommended for use when carrying a child. Ribomunil for children
General provisions
Ribomunil can be used in children from six months, since the drug is safe and well tolerated.For young children, it is better to use Ribomunil in the form of granules, which are diluted in water to form a solution. After all, it is easier for children to drink a solution than to swallow a pill. In principle, you can choose the dosage form of Ribomunil for a child (granules or tablets) solely on the basis of his preferences. For example, if a child tolerates tablets well and does not experience any physical or psychological difficulties associated with the need to swallow them, then this dosage form can be used. If the baby does not like to drink pills, then it is recommended to use Ribomunil in granules. In general, the granule option is considered by manufacturers and physicians as a fallback option, which is used when the main form (tablets) cannot be used normally.
During the period of taking Ribomunil in children, as well as in adults, the temperature may rise for 2-3 days and mild symptoms of respiratory tract infections and ENT organs appear. These manifestations pass on their own and do not require special treatment and discontinuation of the drug. The temperature can be brought down, but it is recommended to do this only in cases where the child does not tolerate it satisfactorily.
In order to prevent infectious diseases in the autumn-winter period, it is recommended to start taking Ribomunil in advance, at least in August-September. In addition, practicing pediatricians recommend taking a prophylactic course of Ribomunil 2 to 6 months before the expected date the child will start visiting kindergarten. This will increase the baby's immunity to infections, as a result of which it will be less likely and much easier to get sick.
The use of Ribomunil and excessive stimulation of the immune system
Many parents believe that Ribomunil stimulates the immune system too much, as a result of which, while the effect of the drug lasts, the child does not get sick, and as soon as it ends, frequent and very serious illnesses begin. Having a similar sequence of events, the parents believe that it is precisely because of Ribomunil. And on this basis, they conclude that it is better to endure the frequent illnesses of a child attending kindergarten than to first stimulate his immunity, and then he will drop sharply. In fact, such a representation is a primitivization, coarsening and drawing of that picture of the world, which is convenient and simple. In reality, everything is more complex and does not obey simple linear interdependencies.So, in children under 6 - 7 years old, the non-specific link of immunity, which is responsible for the destruction of pathogenic microbes that have fallen on the mucous membranes of the respiratory tract, ENT organs, bladder and urethra, is inferior, and that is why the baby constantly catches colds and suffers from various acute respiratory infections, SARS, influenza and other infections. Another link - specific immunity - is fully developed in a child by the time of birth, and therefore his body produces antibodies to bacteria quite normally, which explains the effectiveness of vaccinations.
That is, the ingestion of almost any virus on the mucous membranes of the upper respiratory tract and respiratory tract will cause a disease in the child. In an adult with full-fledged non-specific immunity, such accidentally introduced viruses, bacteria or protozoa will be quickly destroyed, and he will not get sick, just 2-3 days he will not feel very good.
Hardening, proper nutrition and other useful procedures will not be able to solve this problem, since it is its physiological feature. If a child is tempered, then he simply will not catch a cold. But with any contact with a pathogenic microbe, he will get sick due to his age characteristics. Since children are in close contact with each other in kindergarten, they are sure to transmit various microbes to others. And since these contacts cannot be limited, a child attending a kindergarten will be constantly sick. If the baby is surrounded by his relatives, then he will rarely get sick, because he is accustomed to family microbes from birth and has already developed immunity. These are the physiological features of this age.
By the age of 5-7, when nonspecific immunity is fully formed, the child will stop getting sick, because in him, like in an adult, pathogenic microbes that accidentally get on mucous membranes will be quickly and effectively destroyed. But before this age, any child will get sick. More or less, longer or shorter - it depends on the individual characteristics of the organism and heredity, but it will hurt.
If, however, artificially increase the activity of the non-specific link of immunity and maintain it in this state up to 5-7 years, then the child will get sick less, and the course of infections will be easier. This is exactly what Ribomunil does - it enhances non-specific immunity and creates immunity to severe bacterial infections, in a certain sense, making life easier for the child. That is, Ribomunil is an effective and safe assistant that helps the child's body to go through this period of constant illness with the least loss and strain. That is why it is recommended that children who are often and seriously ill be given Ribomunil in regular courses until they reach 6 or 7 years of age, at which time their nonspecific immunity will fully develop and protect them from persistent infections.
Frequent and severe illnesses after the end of the action of Ribomunil are not explained by the fact that the drug overstrained the immune system, after which it fell heavily, but by the fact that the immature nonspecific immune defense remains without support, and the child is susceptible to infection by various microbes. That is, the child begins to get sick precisely because of the expiration of the immunity support, which is still immature and defective.
Ribomunil for children - instructions for use
A single dose (1 dose) is 1 tablet 750 mcg, 1 sachet of granules or 3 tablets 250 mcg. This means that the indicated number of tablets or granules is taken at one time. The drug should be given to the child half an hour before meals. In this case, the tablets must be washed down with water, and the granules should be dissolved in half a glass of water at room temperature. A single dose of Ribomunil is taken only once a day.The drug can be started at any time, regardless of whether the child is completely healthy. However, if the baby is sick, then Ribomunil is used in combination with the usual, standard treatment.
So, Ribomunil in the first month of treatment must be taken one dose during the first four days of three weeks inclusive. That is, the child should be given one dose of the drug from Monday to Thursday in the first, second and third weeks.
Then for the next 2 to 5 months, Ribomunil should be taken one dose per day for the first four days of each month. The first days of each month are the dates on which the very first four tablets were drunk. For example, the first pills were given to the child from the 10th to the 13th of the month, after which he took them for three weeks, 4 days each. This means that after a three-week treatment, from the 10th to the 13th of the next 2-5 months, he will need to be given one dose per day for 4 days (for more details, see the section for prevention and during illness or angioedema.
Contraindications for use
Ribomunil is contraindicated if an adult or child has the following conditions or diseases:- Autoimmune diseases (for example, Hashimoto's thyroiditis, rheumatoid arthritis, etc.);
- Hypersensitivity or individual intolerance to any components of the drug.
Ribomunil - analogues
Currently, there are no synonyms for Ribomunil on the pharmaceutical market, but there are analogues. Analogues are drugs containing other active ingredients, but with a similar spectrum of therapeutic activity.So, the following medicines are analogues of Ribomunil:
- Arpetolid tablets;
- Arpeflu tablets;
- Bioaron C syrup;
- Broncho-Vaksom adult and children's capsules;
- Poludan nasal drops and lyophilisate for the preparation of drops;
- Ruzam nasal drops and solution for subcutaneous administration;
- Taktivin solution for injection;
- Tsitovir-3 capsules, syrup and powder for oral solution;
- Engystol tablets;
- Estifan tablets;
- Echinacea purpurea extract, oral liquid;
- Echinacea granules, drops and lozenges for oral administration;
- Echinacea lozenges;
- Echinacin liquidum oral solution;
- Echinocor Elixir.
Composition and form of release
in a blister 4 pcs.; in a box 1 blister.
in a blister 12 pcs.; in a box 1 blister.
in sachets of 500 mg; in a box of 4 sachets.
Description of the dosage form
Pills: round, biconvex, white or almost white, odorless.
Granules: white, odorless.
pharmachologic effect
pharmachologic effect- immunomodulatory.Pharmacodynamics
The ribosomal-proteoglycan complex is one of the most common pathogens of infections of the upper respiratory tract and respiratory tract, it belongs to the stimulators of specific and nonspecific immunity. Its constituent ribosomes contain antigens that are identical to the surface antigens of bacteria, and when they enter the body, they cause the formation of specific antibodies to these pathogens (vaccine effect). Membrane proteoglycans stimulate nonspecific immunity, which is manifested in increased phagocytic activity of macrophages and polynuclear leukocytes, and an increase in nonspecific resistance factors. The drug stimulates the function of T- and B-lymphocytes, the production of serum and secretory immunoglobulins such as IgA, IL-1, as well as alpha and gamma interferon. This explains the preventive immunity of Ribomunil against respiratory viral infections. The use of Ribomunil in complex therapy improves the effectiveness and reduces the duration of treatment, significantly reduces the need for antibiotics, bronchodilators, and increases the period of remission.
Indications for Ribomunil
prevention and / or treatment of recurrent infections of the ENT organs (otitis media, sinusitis, rhinitis, pharyngitis, laryngitis, tonsillitis) and respiratory tract infections (chronic bronchitis, tracheitis, pneumonia, infectious-dependent bronchial asthma) in patients older than 6 months;
prevention of recurrent infections in patients at risk (often and long-term ill, before the start of the autumn-winter season, especially in environmentally unfavorable regions, in patients with chronic diseases of the ENT organs, chronic bronchitis, bronchial asthma, including in children from 6 months and elderly patients).
Contraindications
hypersensitivity;
autoimmune diseases.
Use during pregnancy and lactation
It is possible to use during pregnancy and during breastfeeding, if the expected effect of therapy outweighs the potential risk to the fetus and child.
Side effects
Occur rarely, characterized by the following conditions:
Transient hypersalivation (at the beginning of treatment);
Allergic reactions (urticaria, angioedema);
Nausea, vomiting, diarrhea.
Interaction
Not installed. Can be combined with other drugs (antibiotics, bronchodilators, anti-inflammatory drugs).
Dosage and administration
inside(adults and children over 6 months), 1 time per day, in the morning, on an empty stomach. A single dose (regardless of age) is 3 tablets. 0.25 mg (from 1/3 of a single dose) or 1 tab. 0.75 mg (with 1 dose), or granules from 1 sachet, previously dissolved with boiled water at room temperature. In the first month of treatment and / or for prophylactic purposes, Ribomunil is taken daily 4 days a week for 3 weeks, in the next 5 months - the first 4 days of each month. Young children are recommended to use granules.
special instructions
Patients should be warned about the possibility of a transient increase in body temperature for 2-3 days, which is a manifestation of the therapeutic effect of the drug and does not usually require discontinuation of treatment. An increase in temperature is sometimes accompanied by minor and transient symptoms of ENT infections.
Ribomunil storage conditions
At a temperature of 15-25 °C.Keep out of the reach of children.
Ribomunil expiration date
tablets 0.25 mg + 0.75 mg 0.25 mg + 0.75 - 5 years.
tablets 0.75 mg + 1.125 mg 0.75 mg + 1.125 - 3 years.
tablets 0.75 mg - 3 years.
granules for oral solution preparation 0.75 mg - 3 years.
Do not use after the expiry date stated on the packaging.
Synonyms of nosological groups
| Category ICD-10 | Synonyms of diseases according to ICD-10 |
|---|---|
| H66 Suppurative and unspecified otitis media | Bacterial ear infections |
| Inflammation of the middle ear | |
| ENT infections | |
| Infectious and inflammatory diseases of the ENT organs | |
| Infectious and inflammatory diseases of the ear | |
| Infectious diseases of ENT organs with severe pain syndrome | |
| ear infection | |
| Otitis media infectious | |
| Persistent otitis media in children | |
| ear pain with otitis media | |
| H70 Mastoiditis and related conditions | mastoiditis |
| J01 Acute sinusitis | Inflammation of the paranasal sinuses |
| Inflammatory diseases of the paranasal sinuses | |
| Purulent-inflammatory processes of the paranasal sinuses | |
| Infectious and inflammatory disease of the ENT organs | |
| Sinus infection | |
| Combined sinusitis | |
| Exacerbation of sinusitis | |
| Acute inflammation of the paranasal sinuses | |
| Acute bacterial sinusitis | |
| Acute sinusitis in adults | |
| Subacute sinusitis | |
| sinusitis acute | |
| sinusitis | |
| J02.9 Acute pharyngitis, unspecified | Purulent pharyngitis |
| Lymphonodular pharyngitis | |
| Acute nasopharyngitis | |
| J03.9 Acute tonsillitis, unspecified (tonsillitis, agranulocytic) | Angina |
| Angina alimentary-hemorrhagic | |
| Angina secondary | |
| Angina primary | |
| Angina follicular | |
| Angina | |
| Bacterial tonsillitis | |
| Inflammatory diseases of the tonsils | |
| Throat infections | |
| Catarrhal angina | |
| Lacunar angina | |
| Acute angina | |
| Acute tonsillitis | |
| Tonsillitis | |
| acute tonsillitis | |
| Tonsillar angina | |
| Follicular angina | |
| Follicular tonsillitis | |
| J04 Acute laryngitis and tracheitis | Infectious and inflammatory disease of the ENT organs |
| Laryngitis | |
| Acute laryngitis | |
| Tracheitis acute | |
| Pharyngolaryngitis | |
| J06 Acute infections of the upper respiratory tract, multiple and unspecified | Bacterial infections of the upper respiratory tract |
| Pain in colds | |
| Pain in infectious and inflammatory diseases of the upper respiratory tract | |
| Inflammatory disease of the upper respiratory tract | |
| Inflammatory diseases of the upper respiratory tract | |
| Inflammatory diseases of the upper respiratory tract with difficult to separate sputum | |
| Secondary Influenza Infections | |
| Secondary infections in colds | |
| Flu conditions | |
| Upper respiratory tract infections | |
| Upper respiratory tract infections | |
| Respiratory tract infections | |
| ENT infections | |
| Infectious and inflammatory diseases of the upper respiratory tract | |
| Infectious and inflammatory diseases of the upper respiratory tract and ENT organs | |
| Infectious and inflammatory diseases of the upper respiratory tract in adults and children | |
| Infectious and inflammatory diseases of the upper respiratory tract | |
| Respiratory tract infection | |
| upper respiratory catarrh | |
| Catarrh of the upper respiratory tract | |
| Catarrh of the upper respiratory tract | |
| Catarrhal phenomena from the upper respiratory tract | |
| Cough in diseases of the upper respiratory tract | |
| Cough with a cold | |
| Fever with influenza | |
| SARS | |
| ORZ | |
| ARI with rhinitis | |
| Acute respiratory infection | |
| Acute infectious and inflammatory disease of the upper respiratory tract | |
| Acute common cold | |
| Acute respiratory disease | |
| Acute influenza-like respiratory disease | |
| Sore throat or nose | |
| Cold | |
| Colds | |
| Colds | |
| Respiratory infection | |
| Respiratory diseases | |
| Respiratory infections | |
| Recurrent respiratory tract infections | |
| seasonal colds | |
| Seasonal colds | |
| Frequent colds viral diseases | |
| J18 Pneumonia without specification of pathogen | Alveolar pneumonia |
| community-acquired atypical pneumonia | |
| Community-acquired pneumonia, non-pneumococcal | |
| Pneumonia | |
| Inflammation of the lower respiratory tract | |
| Inflammatory lung disease | |
| Lobar pneumonia | |
| Respiratory and lung infections | |
| Lower respiratory tract infections | |
| Croupous pneumonia | |
| Lymphoid interstitial pneumonia | |
| Nosocomial pneumonia | |
| Exacerbation of chronic pneumonia | |
| Acute community-acquired pneumonia | |
| Acute pneumonia | |
| Focal pneumonia | |
| Pneumonia abscess | |
| Pneumonia bacterial | |
| Lobar pneumonia | |
| Pneumonia focal | |
| Pneumonia with difficulty passing sputum | |
| Pneumonia in AIDS patients | |
| Pneumonia in children | |
| Septic pneumonia | |
| Chronic obstructive pneumonia | |
| chronic pneumonia | |
| J22 Acute lower respiratory infection, unspecified | bacterial disease of the respiratory tract |
| Bacterial infections of the lower respiratory tract | |
| Bacterial respiratory infections | |
| Viral respiratory disease | |
| Viral infections of the respiratory tract | |
| Inflammatory diseases of the respiratory tract | |
| Difficult sputum separation in acute and chronic respiratory diseases | |
| Respiratory tract infections | |
| Respiratory and lung infections | |
| Lower Respiratory Infections | |
| Lower respiratory tract infections | |
| Infectious inflammation of the respiratory tract | |
| Infectious diseases of the respiratory tract | |
| Infectious diseases of the lungs | |
| Infectious diseases of the respiratory system | |
| Respiratory tract infection | |
| Cough with a cold | |
| Lung infection | |
| Acute respiratory tract infection | |
| Acute respiratory viral infection | |
| Acute inflammatory disease of the airways | |
| Acute respiratory disease | |
| Respiratory infection | |
| Respiratory viral infections | |
| Respiratory syncytial virus infection in young children | |
| Respiratory diseases | |
| Respiratory infections | |
| J31.0 Chronic rhinitis | Atrophic rhinitis with crusting |
| Hypertrophic rhinitis | |
| Runny nose fetid | |
| Exacerbation of chronic rhinitis | |
| Polypous rhinosinusitis | |
| Rhinitis hyperplastic | |
| Chronic hyperplastic rhinitis | |
| Rhinitis chronic | |
| Rhinitis chronic atrophic fetid | |
| Rhinitis chronic atrophic simple | |
| Rhinitis chronic hypertrophic | |
| Dry rhinitis | |
| Chronic atrophic rhinitis | |
| J42 Chronic bronchitis, unspecified | allergic bronchitis |
| Asthmoid bronchitis | |
| Bronchitis allergic | |
| Bronchitis asthmatic | |
| Bronchitis chronic | |
| Inflammatory disease of the airways | |
| Bronchial disease | |
| Qatar smoker | |
| Cough in inflammatory diseases of the lungs and bronchi | |
| Exacerbation of chronic bronchitis | |
| Recurrent bronchitis | |
| Chronic bronchitis | |
| Chronic obstructive pulmonary disease | |
| Chronical bronchitis | |
| Chronic bronchitis of smokers | |
| Chronic spastic bronchitis | |
| J45.8 Mixed asthma | Asthma bronchial infectious-allergic |
| Infectious-allergic asthma | |
| Infectious-allergic bronchial asthma |
Ribomunil: instructions for use and reviews
Latin name: Ribomunyl
ATX code: LO3AX
Active substance: Ribosomal-proteoglycan complex with antigens of typical bacteria
Manufacturer: Pierre Fabre Medicament Production (France)
Description and photo update: 05.11.2017
Ribomunil is a drug of bacterial origin, a stimulant of nonspecific and specific immunity.
Release form and composition
Dosage forms:
- Tablets: round, biconvex, almost white or white, odorless (12 or 4 pieces in blisters, 1 blister in a carton box);
- Granules for the preparation of a solution for oral administration: white, odorless (1 dose per sachet, 4 sachets in a carton box).
Active ingredients:
- Bacterial ribosomes titrated to 70% ribonucleic acid (including 3.5 shares of Klebsiella pneumoniae ribosomes, 3 shares of Streptococcus pneumoniae ribosomes, 3 shares of Streptococcus pyogenes ribosomes, 0.5 shares of Haemophilus influenzae ribosomes): in 1 tablet - 0.25 mg or 0 .75 mg, in 1 sachet - 0.75 mg;
- Proteoglycans of the membrane part (including 15 shares of Klebsiella pneumoniae): in 1 tablet - 0.375 mg or 1.125 mg, in 1 sachet - 1.125 mg.
Excipients:
- Tablets: colloidal hydrophobic silicon, magnesium stearate, sorbitol;
- Granules: silicon, polyvidone, magnesium stearate, D-mannitol, sorbitol.
Pharmacological properties
Ribomunil ensures the development of a specific and non-specific immune response to infectious diseases of the upper respiratory tract, which contributes to the emergence of antibacterial and activation of antiviral immunity. The drug has immunogenic and immunomodulatory properties, which indicates the ability of its active components to penetrate the intestinal mucosa.
The composition of Ribomunil includes the membrane fraction of Klebsiella pneumonia, which interacts with the receptors of the cells of the immune system responsible for the development of innate immunity. These receptors are expressed by cells of the innate immune system, which leads to an increase in the activity of Ribomunil in relation to a nonspecific immune response. The latter consists in enhancing the functional activity of neutrophils (adhesion and migration) and activating natural killers and monocytes/macrophages. Ribomunil also accelerates the maturation of human dendritic cells, which stimulates the proliferation of T-cells, causing a specific response of the immune system to the ribosomal fractions of the drug.
Pharmacodynamics
Structural biochemical analysis proves the presence of macromolecules on ribosomes belonging to the corresponding antigens, which are usually expressed on the walls of bacterial cells. Each ribosomal fraction is immunogenic due to the active interaction of RNA and ribosomal macromolecules. Its action is similar to that of the vaccine antigen and leads to the production of specific cells that synthesize antibodies in the mucous membranes and blood. These cells locally produce special antibodies that can distinguish between antigens of the whole bacterial cell and reduce the adhesion of bacteria to epithelial cells.
Pharmacokinetics
Ribomunil is characterized by good bioavailability. Its active components reach the Peyer's patches of the intestine, where they stimulate the activity of immunocompetent cells.
The macromolecules contained in the drug do not participate in any special metabolic processes, so the likelihood of the drug entering into drug interactions is negligible.
Indications for use
The use of Ribomunil is indicated for the prevention and / or treatment of recurrent infections of the ear, nose, throat and respiratory tract, including in patients at risk:
- Otitis;
- Rhinitis, sinusitis;
- Laryngitis, pharyngitis, tonsillitis;
- Chronical bronchitis;
- Infection-dependent bronchial asthma;
- Pneumonia;
- Tracheitis.
Contraindications
- Age up to 6 months;
- Autoimmune pathologies;
- Individual intolerance to the components of the drug.
Use during pregnancy and breastfeeding is possible if the expected effect of therapy for the mother is higher than the potential risk to the fetus or child.
Instructions for use Ribomunil: method and dosage
Tablets and granules are intended for oral administration, in the morning, before breakfast, once a day.
Before taking the granules should be dissolved in boiled water at room temperature. It is expedient to appoint granules to children of early age.
A single dose of Ribomunil for children and adults is 0.75 mg, which corresponds to 3 tablets of 0.25 mg, or 1 tablet of 0.75 mg, or 1 sachet of granules.
For treatment and / or prevention, the drug is taken: for three weeks of the first month of therapy - 4 consecutive days a week, then 5 months - on the first 4 days of each month.
Side effects
- Allergic reactions: rarely - urticaria, angioedema;
- Other: rarely - diarrhea, nausea, vomiting, at the beginning of the application - a transient increase in the secretion of the salivary glands (hypersalivation).
Overdose
At the moment, no cases of drug overdose have been reported.
special instructions
According to the instructions, Ribomunil can cause a transient increase in temperature for two to three days, so patients should be warned about this manifestation of the therapeutic effect of the drug. In addition, the development of transient minor symptoms of infections of the otorhinolaryngological organs is possible. Usually these conditions do not require discontinuation of treatment.
The risk group includes long-term and frequently ill patients from 6 months to the elderly, including those with chronic pathologies of the respiratory organs. Prophylactic administration of the drug is carried out before the start of the autumn-winter season, especially in regions with unfavorable ecology.
The appointment of an immunomodulating agent as part of complex therapy improves the effectiveness and reduces the duration of treatment, significantly reduces the need for antibiotics, bronchodilators, and prolongs the period of remission.
Application in childhood
The use of Ribomunil for children is possible according to the indications and according to the dosing regimen.
drug interaction
Clinically significant drug interactions of Ribomunil have not been established.
Simultaneous use of anti-inflammatory and bronchodilators, antibiotics is shown.
Analogues
There is no information about the analogues of Ribomunil.
Terms and conditions of storage
Store at 15-25°C. Keep away from children.
Shelf life: 0.75 mg tablets and granules - 3 years, 0.25 mg tablets - 5 years.