Ribomunil: instructions for use, analogues and reviews, prices in Russian pharmacies. Ribomunil - instructions for use for children and adults Indications for use and therapeutic effects of the drug


Latin name: Ribomunyl
ATX code: L03AX
Active substance: Ribosomal-
proteoglycan complex
Manufacturer: Pierre Fabre Medication
Production, France
Pharmacy leave condition: Without recipe
Price: from 350 to 1050 rubles.

“Ribomunil” (synonymous with Ribomunal granulate) is a unique remedy consisting of a complex of ribosomes, which include pathogens of infectious diseases of the respiratory system. When the drug enters the body, it creates the effect of vaccination, thereby activating the formation of antibodies to these viruses.

According to doctors, this is one of the most effective medicines, thanks to which you can get a stable immune system to many infectious diseases of the ENT organs and the respiratory system.

Indications for use

Reception of "Ribomunil" begins with such indications:

  • For the treatment and prevention of infectious ENT diseases (otitis media, laryngitis, tonsillitis, pharyngitis, etc.) in children older than six months
  • In the treatment and prevention of infectious pathologies of the respiratory system (bronchitis, pneumonia, infectious bronchial asthma) in children from 6 months
  • To prevent ailments in people who often suffer from respiratory and chronic diseases, especially in the autumn-winter period. You can take medicine for all age categories, including people of retirement age and children older than six months.

Compound

"Ribomunil" tablets include in their composition the main active ingredient bacterial ribosomes, titrated to 70% ribonucleic acid. Auxiliary ingredients: magnesium sterart, silicon, sorbitol.

"Ribomunil" granules are intended for solution preparation. Active ingredient: bacterial ribosomes 0.75 mg, additional substances: polyvidone, D-mannitol.

Medicinal properties

The drug is considered to be an immunomodulator of bacterial origin. It consists of a ribosomal-proteoglycan association, which includes a large number of causative agents of colds and respiratory tract infections. "Ribomunil" stimulates the production of antibodies to incoming microorganisms, thereby increasing the defenses and the human immune system.

With complex treatment, the active substance significantly improves the patient's condition, greatly reduces the duration of treatment, reduces the frequency and need for the use of antibiotics and bronchodilators. The medicine can be taken regardless of whether the body temperature is elevated or not.

The average price is from 400 to 1050 rubles.

"Ribomunil", tablets

Tablets are round, convex, white in color, odorless. Available in 0.25 mg and 0.75 mg. Tablets with a dosage of 0.25 mg, 12 pcs. in a blister, 0.75 mg - 4 pcs. in a blister. Sold in packs of cardboard, with attached instructions.

Application methods

"Ribomunil" should be taken once a day before meals, in the morning on an empty stomach, regardless of whether the body temperature is elevated or not. The treatment regimen with "Ribomunil" is the same for adults and children under one year old. A single dose is 0.75 mg of the drug (1 tablet).

In the case of therapy or prophylaxis, it is important to use the drug for 3 weeks, on the first 4 days of each week. Further reception is carried out within 5 months, on the first four days of each month.

Also, in order to prevent the disease, it is better to take “Ribomunil” for 3 months, 2-3 times a year, taking breaks.

The average price is from 350 to 450 rubles.

Granules “Ribomunil”

The granules are white in color, odorless. They are packaged in paper laminated bags of 500 mg of the substance, 4 bags in one package.

Mode of application

In the case of taking the powder, the dosage does not change. One sachet should be poured into a glass of warm water and stirred until completely dissolved. Often, taking granules is more effective for children under one year old.

Contraindications and precautions

The main contraindications for which it is not recommended to take the medication are:

  • Autoimmune pathologies
  • Intolerance to active ingredients.

When the temperature rises, the symptoms of the disease become more pronounced, you should not stop taking the medication, because doctors say that this is a manifestation of a therapeutic effect.

During pregnancy and breastfeeding

It is forbidden to take medicine when a woman is expecting a baby and breastfeeding. If its use is unavoidable, then the doctor carefully evaluates the ratio of benefit to the woman and the risk to the child.

Cross-drug interactions

The drug is allowed to be taken in combination with drugs such as antibiotics, anti-inflammatory drugs, bronchodilators.

Side effects

While taking the drug, side effects are rare. In patients in the first days of using the drug, hypersalization may occur. Allergies (urticaria, swelling), as well as nausea or vomiting, diarrhea may also occur.

Terms and conditions of storage

"Ribomunil" should be stored in a place closed from children, at a temperature of 15 to 25 degrees.

Analogues

"Bronchomunal". "Bronchomunal" or "Ribomunil", which is better?

Lek d.d., Slovenia / Sandoz, Switzerland
Price from 132 to 1470 rubles.

The drug is an immunostimulating drug of bacterial origin. It is produced in the form of capsules containing a light beige powder. One capsule contains lyophilized bacterial lysate and excipients. Bronchomunal is indicated for respiratory infections and colds, both in a child and in adult patients.

pros

  • Effective as a prophylactic
  • Can be taken in combination with other drugs

Minuses

  • High price
  • At reception disturbances from the alimentary system are possible.

Lek, Slovenia
Price from 300 to 350 rubles.

"Immunal" is the best immunostimulating agent, consisting of natural components of plant origin. It is presented by the manufacturer in the form of tablets and solution, which are intended for the prevention and complex treatment of infectious and catarrhal ailments.

pros

  • Strengthens the immune system
  • natural preparation
  • Can be given to children

Minuses

  • Possible allergic reaction
  • Not recommended for pregnant women and while breastfeeding.

Ribomunil: instructions for use and reviews

Latin name: Ribomunyl

ATX code: LO3AX

Active substance: Ribosomal-proteoglycan complex with antigens of typical bacteria

Manufacturer: Pierre Fabre Medicament Production (France)

Description and photo update: 05.11.2017

Ribomunil is a drug of bacterial origin, a stimulant of nonspecific and specific immunity.

Release form and composition

Dosage forms:

  • Tablets: round, biconvex, almost white or white, odorless (12 or 4 pieces in blisters, 1 blister in a carton box);
  • Granules for the preparation of a solution for oral administration: white, odorless (1 dose per sachet, 4 sachets in a carton box).

Active ingredients:

  • Bacterial ribosomes titrated to 70% ribonucleic acid (including 3.5 shares of Klebsiella pneumoniae ribosomes, 3 shares of Streptococcus pneumoniae ribosomes, 3 shares of Streptococcus pyogenes ribosomes, 0.5 shares of Haemophilus influenzae ribosomes): in 1 tablet - 0.25 mg or 0 .75 mg, in 1 sachet - 0.75 mg;
  • Proteoglycans of the membrane part (including 15 shares of Klebsiella pneumoniae): in 1 tablet - 0.375 mg or 1.125 mg, in 1 sachet - 1.125 mg.

Excipients:

  • Tablets: colloidal hydrophobic silicon, magnesium stearate, sorbitol;
  • Granules: silicon, polyvidone, magnesium stearate, D-mannitol, sorbitol.

Pharmacological properties

Ribomunil ensures the development of a specific and non-specific immune response to infectious diseases of the upper respiratory tract, which contributes to the emergence of antibacterial and activation of antiviral immunity. The drug has immunogenic and immunomodulatory properties, which indicates the ability of its active components to penetrate the intestinal mucosa.

The composition of Ribomunil includes the membrane fraction of Klebsiella pneumonia, which interacts with the receptors of the cells of the immune system responsible for the development of innate immunity. These receptors are expressed by cells of the innate immune system, which leads to an increase in the activity of Ribomunil in relation to a nonspecific immune response. The latter consists in enhancing the functional activity of neutrophils (adhesion and migration) and activating natural killers and monocytes/macrophages. Ribomunil also accelerates the maturation of human dendritic cells, which stimulates the proliferation of T-cells, causing a specific response of the immune system to the ribosomal fractions of the drug.

Pharmacodynamics

Structural biochemical analysis proves the presence of macromolecules on ribosomes belonging to the corresponding antigens, which are usually expressed on the walls of bacterial cells. Each ribosomal fraction is immunogenic due to the active interaction of RNA and ribosomal macromolecules. Its action is similar to that of the vaccine antigen and leads to the production of specific cells that synthesize antibodies in the mucous membranes and blood. These cells locally produce special antibodies that can distinguish between antigens of the whole bacterial cell and reduce the adhesion of bacteria to epithelial cells.

Pharmacokinetics

Ribomunil is characterized by good bioavailability. Its active components reach the Peyer's patches of the intestine, where they stimulate the activity of immunocompetent cells.

The macromolecules contained in the drug do not participate in any special metabolic processes, so the likelihood of the drug entering into drug interactions is negligible.

Indications for use

The use of Ribomunil is indicated for the prevention and / or treatment of recurrent infections of the ear, nose, throat and respiratory tract, including in patients at risk:

  • Otitis;
  • Rhinitis, sinusitis;
  • Laryngitis, pharyngitis, tonsillitis;
  • Chronical bronchitis;
  • Infection-dependent bronchial asthma;
  • Pneumonia;
  • Tracheitis.

Contraindications

  • Age up to 6 months;
  • Autoimmune pathologies;
  • Individual intolerance to the components of the drug.

Use during pregnancy and breastfeeding is possible if the expected effect of therapy for the mother is higher than the potential risk to the fetus or child.

Instructions for use Ribomunil: method and dosage

Tablets and granules are intended for oral administration, in the morning, before breakfast, once a day.

Before taking the granules should be dissolved in boiled water at room temperature. It is expedient to appoint granules to children of early age.

A single dose of Ribomunil for children and adults is 0.75 mg, which corresponds to 3 tablets of 0.25 mg, or 1 tablet of 0.75 mg, or 1 sachet of granules.

For treatment and / or prevention, the drug is taken: for three weeks of the first month of therapy - 4 consecutive days a week, then 5 months - on the first 4 days of each month.

Side effects

  • Allergic reactions: rarely - urticaria, angioedema;
  • Other: rarely - diarrhea, nausea, vomiting, at the beginning of the application - a transient increase in the secretion of the salivary glands (hypersalivation).

Overdose

At the moment, no cases of drug overdose have been reported.

special instructions

According to the instructions, Ribomunil can cause a transient increase in temperature for two to three days, so patients should be warned about this manifestation of the therapeutic effect of the drug. In addition, the development of transient minor symptoms of infections of the otorhinolaryngological organs is possible. Usually these conditions do not require discontinuation of treatment.

The risk group includes long-term and frequently ill patients from 6 months to the elderly, including those with chronic pathologies of the respiratory organs. Prophylactic administration of the drug is carried out before the start of the autumn-winter season, especially in regions with unfavorable ecology.

The appointment of an immunomodulating agent as part of complex therapy improves the effectiveness and reduces the duration of treatment, significantly reduces the need for antibiotics, bronchodilators, and prolongs the period of remission.

Application in childhood

The use of Ribomunil for children is possible according to the indications and according to the dosing regimen.

drug interaction

Clinically significant drug interactions of Ribomunil have not been established.

Simultaneous use of anti-inflammatory and bronchodilators, antibiotics is shown.

Analogues

There is no information about the analogues of Ribomunil.

Terms and conditions of storage

Store at 15-25°C. Keep away from children.

Shelf life: 0.75 mg tablets and granules - 3 years, 0.25 mg tablets - 5 years.

Bacterial ribosomes titrated to 70% ribonucleic acid - 750 mcg,
(including ribosomes of Klebsiella pneumoniae - 3.5 shares, Streptococcus pneumoniae - 3.0 shares, Streptococcus pyogenes - 3.0 shares, Haemophilus influenzae - 0.5 shares); membranous proteoglycans
Klebsiella pneumoniae - 1.125 mg;

other components: silicon, magnesium stearate, sorbitol.

Indications for use Ribomunil

  • prevention and treatment of recurrent infections of ENT organs (otitis, rhinitis, sinusitis, tonsillitis, pharyngitis, laryngitis) in patients older than 6 months;
  • prevention and treatment of recurrent respiratory tract infections (chronic bronchitis, tracheitis, pneumonia, infectious-dependent bronchial asthma) in patients older than 6 months;
  • prevention of recurrent infections in patients at risk (often and long-term illnesses, before the start of the autumn-winter season, especially in ecologically unfavorable regions, patients with chronic diseases of the upper respiratory tract, chronic bronchitis, bronchial asthma, including the elderly and older children 6 months).

Contraindications for the use of Ribomunil

  • autoimmune diseases;
  • hypersensitivity to the drug.

For adults and children older than 6 months, the drug is prescribed 1 time per day in the morning on an empty stomach. A single dose (regardless of age) is 3 tablets of 0.25 mg (with 1/3 of a single dose), or 1 tablet of 0.75 mg (with a single dose), or granules from 1 sachet, previously dissolved with boiled water at room temperature.

In the first month of treatment and / or for prophylactic purposes, Ribomunil is taken daily for the first 4 days of each week for 3 weeks. In the next 2-5 months - the first 4 days of each month. For young children, the drug is recommended to prescribe in the form of granules.

The use of Ribomunil during pregnancy and lactation

Special studies of the safety and efficacy of Ribomunil during pregnancy and lactation have not been conducted.

The use of Ribomunil during pregnancy and lactation (breastfeeding) is possible only after assessing the intended benefit to the mother and the potential risk to the fetus and child.

pharmachologic effect

Ribomunil is an immunomodulator of bacterial origin. Ribomunil is a ribosomal-proteoglycan complex, which includes the most common pathogens of infections of the upper respiratory tract and respiratory tract.

The ribosomes that make up the drug contain antigens that are identical to the surface antigens of bacteria, and when they enter the body, they cause the formation of specific antibodies to these pathogens (vaccine effect). Membrane proteoglycans stimulate nonspecific immunity, which is manifested in increased phagocytic activity of macrophages and polynuclear leukocytes, and an increase in nonspecific resistance factors. The drug stimulates the function of T- and B-lymphocytes, the production of serum and secretory immunoglobulins of the IgA type, interleukin-1, as well as alpha and gamma interferons. This explains the preventive effect of Ribomunil against respiratory viral infections.

The use of Ribomunil in complex therapy improves the effectiveness and reduces the duration of treatment, significantly reduces the need for antibiotics, bronchodilators, and increases the period of remission.

Side effects of Ribomunil

From the body as a whole: transient hypersalivation at the beginning of treatment.

Allergic reactions: in isolated cases - urticaria, angioedema.

From the digestive system: extremely rarely - nausea, vomiting, diarrhea.

Side effects are rare and do not require discontinuation of the drug.

special instructions

Patients should be warned about the possibility of a transient increase in body temperature for 2-3 days, which is a manifestation of the therapeutic effect of the drug and does not usually require discontinuation of treatment. An increase in temperature can sometimes be accompanied by minor and transient symptoms of ENT infections.

Overdose

At present, no cases of overdose of the drug Ribomunil have been reported.

drug interaction

To date, a clinically significant drug interaction of the drug Ribomunil has not been described. The use of the drug can be combined with other drugs.

Storage conditions

The drug should be stored out of the reach of children and transported (by all types of covered transport) at a temperature of 15° to 25°C.

Shelf life - 3 years.

Frequent illnesses have become the norm for many people, infectious lesions of the ENT organs are especially disturbing. Such situations occur often, as a rule, due to weakened immunity. Modern medicine and pharmacology offer to overcome such ailments with the help of antibiotics that suppress symptoms for a while.

The action of such medications leads to a further relapse of diseases, when the usual remedies no longer help, and new ones are either not developed or are very expensive and have a large number of contraindications. To prevent such consequences, first of all, it is necessary to deal with the restoration of immunity.

For a complete treatment, there are a number of stimulants of immune processes or immunomodulators, which also include the drug "Ribomunil", doctors' reviews indicate that it is a worthy alternative to antibiotics and has a number of advantages over them, including safety of use.

Pharmacology, composition

The drug belongs to the category of immune stimulants of bacterial origin, saturated with various bacteria. From a scientific and medical point of view, the instructions for use, reviews of pharmacists and the opinion of professional doctors speak best of all about the composition and, in general, about the drug "Ribomunil". The composition of the drug differs slightly depending on the form of release. It can be white tablets or granular powder in a special bag.

The full composition of "Ribomunil" in tablets is as follows:

  • bacterial ribosomes, with an RNA level of 70%, among which the ribosomes of Klebsiella pneumonia (Klebsiella pneumoniae) or Friedlander's bacillus occupies 3.5 shares, streptococci (Streptococcus pyogenes and Streptococcus pneumoniae) each has 3.0 shares, and Haemophilus influenzae (Haemophilus influenzae ) - 0.5 shares;
  • proteoglycans of the membrane part, Klebsiella pneumonia is also present in a quantitative value of 15 shares;
  • excipients, including sorbitol, silicon, and magnesium stearate.

Granulated powder "Ribomunil" (instruction, manufacturer's reviews indicate this) differs in composition only in terms of additional components. In this form, instead of those described above, there is D-mannitol (about 490 mg) and 10 mg of polyvidone. The total medication in the package is 500 mg.

Indications for use and therapeutic effects of the drug

Due to the active components and the principle of action of the drug, its use is possible both for the prevention and treatment of diseases of the respiratory tract and ENT organs, and against bronchitis, bronchial asthma and ENT diseases in patients at risk.

The main diseases for which treatment with the drug "Ribomunil" is prescribed (instruction for children, reviews of experts testify) are not much different and the indications for them also correspond to the list below:

  • otitis;
  • pneumonia;
  • Chronical bronchitis;
  • sinusitis;
  • infectious-dependent bronchial asthma;
  • laryngitis;
  • trachyte;
  • pharyngitis;
  • rhinitis.

The main actions that the drug has on the body of patients after the start of use:

  • activates the formation of specific antibodies due to the action of bacteria included in the composition of the active components;
  • has a high immunomodulating effect on the body and helps to resist various infections;
  • with the help of the drug, the resistance factor in a non-specific form is significantly enhanced, as well as phagocytic activity.

The drug can be prescribed for all groups of patients. "Ribomunil" is very well suited for children, reviews of pediatricians suggest that with the help of the medication it is much easier to overcome the adaptation of the child's immunity to attending school or kindergarten. It has also been noted that with the prevention of this drug, diseases, if they do occur, are much easier to tolerate. Also, its use by patients in old age gives positive results.

Contraindications and drug overdose

The drug does not belong to antibiotics or any other heavy drugs, its main action is to form antibodies and increase the patient's immunity, which allows us to talk about its safety for most patients or those in need of prevention of ENT diseases and respiratory tract infections. However, there are a number of cases in which it is desirable to refuse the use of the drug:

  • previously identified intolerance to the drug in general;
  • negative reactions of the body to any of the components included in the composition, some patients categorically should not be allowed to enter the body contained in "Ribomunil" bacteria and rods, regardless of their therapeutic effect;
  • For HIV-infected patients, the drug is prescribed in rare cases and should be taken under the constant supervision of the attending physician;
  • also under control and with extreme caution, the drug is used in patients with periarteritis nodosa.

Regardless of the fact that Ribomunil collects positive reviews and is often recommended, and is also allowed to be taken without much difficulty, before starting treatment, you should consult your doctor and undergo the necessary examination. As for cases of overdose, such cases have not been registered, but do not forget about precautionary measures.

The use of the drug during pregnancy

Sometimes the drug is prescribed to pregnant and lactating women, but there is no final opinion on how justified the use of the drug "Ribomunil". Reviews of specialists in this case should affect not so much the drug as a complex, but rather the active components, the reaction of which in the body can cause reactions that are dangerous for the fetus or breast milk.

As for the instructions for the drug, it says that there are no special studies on the use of the drug by women during pregnancy and breastfeeding, as a rule, such a warning implies the need to abandon the use and find an analogue that will be intended for such treatment.

"Ribomunil" for children, reviews

As part of the use of medication for children, he collected a large number of reviews. The drug can be prescribed from the age of 6 months, if necessary, as a rule, children are prescribed granules that are to be dissolved in water. Due to its effect, the drug can be called one of the leaders in the fight against persistent colds, SARS, inflammation of the respiratory tract, etc., which often occur in children when visiting kindergartens and elementary grades of school, when their immunity is the weakest.

Side effects of the drug "Ribomunil"

As such, the drug has no side effects, however, some patients experience the following symptoms at the beginning of the course:

  • elevated temperature;
  • nausea;
  • angioedema;
  • diarrhea;
  • salivation;
  • symptoms of ENT diseases;
  • hives.

Most of these side effects of the drug "Ribomunil" (instruction, reviews of doctors say) are nothing more than a manifestation of the action of the drug, and if they occur only at the beginning of treatment, it only means that the process of activating the immune system and producing antibodies has begun.

However, if there is an increase in temperature to 39 degrees and above, you should immediately consult a doctor and stop using the drug, since the reaction may occur due to individual intolerance to the elements of the drug.

Means "Ribomunil": reviews

Among doctors, "Ribomunil" has a very positive reputation, very often it is prescribed for diseases associated with weakened immunity or for the prevention of diseases in patients at risk during the off-season, especially for those who live in harmful areas.

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    Now it's impossible to get it! Called all pharmacies and online pharmacies! They answer that he has not been in Russia for a long time at all! Friends are resting in Turkey, she asked me to look, also not! They show them a box (photo), and they answer that they have never had this drug!!! So where do you get it???

    Only thanks to Ribomunil we forgot what it is to get sick every month. single bronchitis. Nephew also helped a lot.

    Before going to the kindergarten, the pediatrician advised us Ribomunil. You know, a lot of reviews about Ribomunil and re-read. Many praised the drug, some, on the contrary, found fault with it, but as you know, each organism has its own perception of any medication. Ribomunil is a kind of vaccine, and we did all the vaccinations, did not refuse. Started taking... Before going to the kindergarten, the pediatrician advised us Ribomunil. You know, a lot of reviews about Ribomunil and re-read. Many praised the drug, some, on the contrary, found fault with it, but as you know, each organism has its own perception of any medication. Ribomunil is a kind of vaccine, and we did all the vaccinations, did not refuse. Started taking a couple of months before going to the garden. I knew perfectly well that in kindergarten a child would get sick many times while adapting to a new environment. But! For 6 months in the garden, we got sick only once, and that one did without a temperature!!! I think it's an indicator. Therefore, Ribomunil is a very effective and necessary drug!