Sorbifer durules side effects. Review: Sorbifer Durules: instructions for use, price, reviews, analogues. How to take Sorbifer Durules tablets before or after meals. Application in childhood
In this article, you can read the instructions for using the drug Sorbifer Durules. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Sorbifer Durules in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Sorbifer Durules in the presence of existing structural analogues. Use for the treatment of iron deficiency in the body, anemia and increased hemoglobin levels in adults, children, as well as during pregnancy and lactation.
Sorbifer Durules- antianemic drug. Iron is an indispensable component of the body, necessary for the formation of hemoglobin and the occurrence of oxidative processes in living tissues.
Durules technology provides a gradual release of the active ingredient (iron ions) over a long time. The plastic matrix of Sorbifer Durules tablets is completely inert in the digestive juice, but completely disintegrates under the action of intestinal peristalsis when the active ingredient is completely released.
Ascorbic acid improves iron absorption.
Compound
Iron sulfate + Ascorbic acid (vitamin C) + excipients.
Pharmacokinetics
Durules is a technology that provides a gradual release of the active substance (iron ions), a uniform flow of the drug. The intake of 100 mg 2 times a day provides a 30% greater absorption of iron from the drug Sorbifer Durules compared to conventional iron preparations. Absorption and bioavailability of iron are high. Iron is absorbed predominantly in the duodenum and proximal jejunum. Plasma protein binding - 90% or more. It is deposited in the form of ferritin or hemosiderin in hepatocytes and cells of the system of phagocytic macrophages, a small amount - in the form of myoglobin in muscles.
Indications
- Iron-deficiency anemia;
- iron deficiency;
- prevention of iron deficiency anemia during pregnancy, lactation, in blood donors.
Release form
Coated tablets.
Instructions for use and regimen
The drug is taken orally. Coated tablets should not be divided or chewed. The tablet should be swallowed whole and washed down with at least half a glass of liquid.
Adults and adolescents are prescribed 1 tablet 1-2 times a day. If necessary, for patients with iron deficiency anemia, the dose can be increased to 3-4 tablets per day in 2 divided doses (morning and evening) for 3-4 months (until the iron depot in the body is replenished).
During pregnancy and lactation, for the purpose of prevention, 1 tablet per day is prescribed; for treatment appoint 1 tablet 2 times a day (morning and evening).
Treatment should be continued until the optimal hemoglobin level is reached. For further replenishment of the depot, it may be necessary to continue taking the drug for another 2 months.
Side effect
- nausea, vomiting;
- stomach ache;
- diarrhea;
- constipation;
- ulcerative lesions of the esophagus;
- stenosis of the esophagus;
- rash;
- headache;
- dizziness;
- skin hyperthermia;
- weakness.
Contraindications
- stenosis of the esophagus and / or other obstructive changes in the digestive tract;
- increased iron content in the body (hemosiderosis, hemochromatosis);
- violation of iron utilization (lead anemia, sideroblastic anemia, hemolytic anemia);
- children under 12 years of age (due to lack of clinical data);
- hypersensitivity to the components of the drug.
Use during pregnancy and lactation
It is possible to use the drug Sorbifer Durules during pregnancy and lactation according to indications.
Use in children
The drug is contraindicated in children and adolescents under 12 years of age.
special instructions
When using the drug, darkening of the feces (black feces) is possible, which has no clinical significance.
With caution, the drug should be used for gastric ulcer and duodenal ulcer, inflammatory bowel disease (enteritis, diverticulitis, ulcerative colitis, Crohn's disease).
drug interaction
Sorbifer Durules may reduce the absorption of concomitantly used enoxacin, clodronate, grepafloxacin, levodopa, levofloxacin, methyldopa, penicillamine, tetracyclines and thyroid hormones.
The simultaneous use of the drug Sorbifer Durules and antacids containing aluminum hydroxide and magnesium carbonate may reduce the absorption of iron. Between taking the drug Sorbifer Durules and any of these drugs should withstand the maximum possible time interval. The recommended minimum interval between doses is 2 hours, except when taking tetracyclines, when the minimum interval should be 3 hours.
Sorbifer Durules should not be combined with the following drugs: ciprofloxacin, doxycycline, norfloxacin and ofloxacin.
Analogues of the drug Sorbifer Durules
Structural analogues for the active substance:
- Fenyuls 100;
- Ferroplex.
Analogues by pharmacological group (drugs for the treatment of iron deficiency):
- Aktiferrin compositum;
- Aloe syrup with iron;
- Biovital elixir;
- Biofer;
- Venofer;
- Vitrum Superstress;
- Vitrum Circus;
- Hemopher;
- Gino Tardiferon;
- Likferr 100;
- Maltofer;
- Maltofer Fall;
- Multi tabs Active;
- Pikovit Complex;
- Special dragee Merz;
- Stress formula with iron;
- Supradin Kids Junior;
- Tardiferon;
- totem;
- Ferlatum;
- Ferretab;
- Ferrinat;
- Ferro Folgamma;
- Ferrogradumet;
- Ferronal;
- Ferronal 35;
- Ferrum Lek;
- Heferol;
- Enfamil Premium 2;
- Enfamil with iron.
In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.
Sorbifer Durules is an anti-anemic drug.
Release form and composition
Dosage form Sorbifer Durules - tablets: round, biconvex, film-coated light yellow, engraved "Z" on one side; on a break, a gray core with a characteristic odor (30 or 50 pieces in dark glass bottles, 1 bottle in a cardboard box).
Active ingredients (in 1 tablet):
- Iron sulfate (II) - 320 mg (which is equivalent to the content of Fe 2+ - 100 mg);
- Ascorbic acid - 60 mg.
Auxiliary components: polyethylene powder, povidone K-25, carbomer 934R and magnesium stearate.
Shell composition: solid paraffin, titanium dioxide, macrogol 6000, hypromellose, yellow iron oxide.
Indications for use
- Treatment: iron deficiency, iron deficiency anemia;
- Prevention: Iron deficiency anemia in pregnant and breastfeeding women and blood donors.
Contraindications
Absolute:
- Violation of iron utilization (sideroblastic, lead or hemolytic anemia);
- Increased iron content in the body (hemochromatosis, hemosiderosis);
- Esophageal stenosis and / or other obstructive changes in the digestive tract;
- Children's age up to 12 years;
- Hypersensitivity to the components of the drug.
Relative (special care required):
- Peptic ulcer of the stomach and duodenum;
- Inflammatory bowel diseases: Crohn's disease, ulcerative colitis, enteritis and diverticulitis.
Method of application and dosage
The drug should be taken orally. Tablets should be swallowed whole, without splitting or chewing, with at least 1/2 glass of liquid.
Children over 12 years of age and adults are prescribed 1 tablet 1-2 times a day.
For patients with iron deficiency anemia, if necessary, the dose is increased to 3-4 tablets per day in 2 divided doses (morning and evening). The duration of the course is determined by the replenishment of the iron depot in the body and is usually 3-4 months.
During pregnancy and lactation, it is prescribed: for prevention - 1 tablet 1 time per day, for lactation - 1 tablet 2 times a day (morning and evening).
Treatment should be continued until the optimal hemoglobin level is reached. For further replenishment of the depot, you can add another 2 months to the duration of the intake.
Side effects
Possible adverse reactions due to Sorbifer Durules:
- Digestive system: abdominal pain, nausea and / or vomiting, constipation or diarrhea (when the dose is increased to 400 mg, the frequency of these side effects may increase); rarely - stenosis of the esophagus, ulcerative lesions of the esophagus;
- Central nervous system: rarely - dizziness, headache;
- Allergic reactions: rarely - itching and rash;
- Other: rarely - general weakness, hyperthermia of the skin.
When taking an excessive dose of the drug, the following are possible: vomiting, abdominal pain, diarrhea with an admixture of blood, pallor of the skin, weakness or fatigue, paresthesia, cold, sticky sweat, hyperthermia, acidosis, lowering blood pressure, weak pulse, rapid heartbeat; in severe cases - hypoglycemia, coagulopathy, signs of peripheral circulatory collapse, hyperthermia, renal failure, liver damage, after 6-12 hours, muscle cramps and coma may appear.
In case of taking too high a dose of Sorbifer Durules, you should immediately consult a doctor. Overdose treatment measures: gastric lavage, raw egg and milk intake (these products bind iron ions in the gastrointestinal tract), the introduction of deferoxamine. Further therapy is symptomatic.
special instructions
During the period of use of the drug, darkening of the feces is possible. This phenomenon has no clinical significance.
drug interaction
Antacids containing magnesium carbonate and aluminum hydroxide may reduce iron absorption. And Sorbifer Durules can reduce the absorption of concomitantly used thyroid hormones, tetracyclines, clodronate, enoxacin, grepafloxacin, methyldopa, levofloxacin, penicillamine, levodopa.
For this reason, at least 2-hour intervals should be observed between taking iron sulfate with any of these agents, and in the case of tetracyclines, 3-hour intervals.
Terms and conditions of storage
Store at a temperature of 15-25 ° C, out of the reach of children.
Shelf life - 3 years.
Instructions for medical use
medicinal product
Sorbifer ® Durules ®
Tradename
Sorbifer ® Durules ®
International non-proprietary name
Dosage form
Coated tablets
Compound
One tablet contains
active substances: dry iron (II) sulfate 320 mg (equivalent to 100 mg iron (II)), ascorbic acid 60 mg,
Excipients: povidone (K-25), polyethylene powder, carbomer 934 R, magnesium stearate,
shell composition: hypromellose, macrogol 6000, titanium dioxide E 171, iron (III) oxide yellow E 172, hard paraffin.
Description
Lenticular-shaped, slightly biconvex, film-coated ocher-yellow tablets, engraved with "Z" on one side, with a characteristic odor.
Pharmacotherapeutic group
Stimulants of hematopoiesis. Iron preparation. Fe++ preparations for oral administration.
ATX code B03A A
Pharmacological properties
Pharmacokinetics
"Durules" is a special production technology that provides a gradual release of the active substance (iron ions), a uniform flow of the drug. Iron is absorbed mainly in the duodenum and proximal jejunum. Taking 100 mg twice a day provides a 30% greater absorption of iron from Sorbifer Durules compared to conventional iron preparations. Absorption and bioavailability of iron are high. Communication with plasma proteins - 90% or more. It is deposited in the form of ferritin and hemosiderin in hepatocytes and cells of the system of phagocytic macrophages, a small amount - in the form of myoglobin in the muscles. The half-life is 6 hours.
The presence of ascorbic acid in the preparation creates more favorable conditions for the absorption of iron in the intestine. At the molecular level, ascorbic acid mobilizes iron from the crystalline core of ferritin. in vitro, reducing Fe 3+ to Fe 2+ . At the intracellular level, ascorbic acid enhances iron-induced translation of ferritin by promoting the conversion of iron regulatory protein (IRP) from RNA-bound form to aconitase.
Pharmacodynamics
Iron is an indispensable component of the body, necessary for the formation of hemoglobin and the implementation of oxidative processes in living tissues. The active substance is contained in a biologically indifferent plastic matrix of a spongy structure. When passing through the gastrointestinal tract from the porous matrix of tablets (within 6 hours), there is a continuous release of ferrous ions. The film coating of the tablet and the porous matrix provide a long-term release of iron ions. Prevention of dissolution of the tablet in the stomach contributes to the film coating of the tablet, which completely disintegrates under the action of intestinal peristalsis, when the active ingredient is released. The slow release of iron ions does not lead to a high local concentration, which avoids irritation of the gastrointestinal mucosa.
Ascorbic acid slows down the breakdown of ferritin by blocking the autophagy of ferritin by ferritin lysosomes and the transformation into hemosiderin.
Ascorbic acid accelerates the absorption of iron in the gastrointestinal tract, restoring unbound heme iron (III) to iron (II) in the stomach.
Indications for use
Iron-deficiency anemia
Latent iron deficiency in the body (without anemia) associated with excessive iron loss (bleeding, including uterine bleeding, constant donation), malnutrition
Conditions accompanied by an increased need for iron in the body (prevention during pregnancy, lactation and in blood donors)
Dosage and administration
The tablet should be taken whole, without chewing, and at least half an hour before a meal, with half a glass of water.
Adults and teenagers over 12 years of age:
For patients with iron deficiency anemia II-III degree, if necessary, on the recommendation of a doctor, the dose can be increased to 3-4 tablets 2 times a day (morning and evening) with a duration of use for 3-6 months.
During pregnancy:
The drug is used in case of established iron deficiency (with iron deficiency anemia and latent iron deficiency in the body)
Prophylactic dose: 1 tablet per day.
Therapeutic dose: 1 tablet 2 times a day (morning and evening).
Treatment should be carried out until the hemoglobin level normalizes and continue until the iron depot is completely saturated for another 2 months. Individual long-term therapy (with or without interruptions) is indicated for regularly occurring significant iron loss (for example, with heavy menstruation).
Side effects
The frequency of side effects from the digestive system increases with increasing doses from 100 to 400 mg per day.
Often (>1/100)
Nausea, abdominal pain, diarrhea, constipation
Rarely (<1/100)
- esophageal ulcer, esophageal stenosis
Allergic reactions (itching, rash, hyperemia)
hyperthermia
Contraindications
Hypersensitivity to the active or any other inactive component of the drug
Esophageal stenosis and/or other obstructive changes in the digestive tract
Increased iron content in the body (hemosiderosis, hemochromatosis)
Repeated blood transfusions
Impaired iron utilization (lead anemia, sideroblastic anemia, hemolytic anemia)
Children under 12 years of age (due to lack of clinical data)
Drug Interactions
- ciprofloxacin: simultaneous administration reduces the absorption of ciprofloxacin by approximately 50%, so that there is a risk that the content of ciprofloxacin in the blood plasma will be lower than necessary for a therapeutic effect.
- levofloxacin: simultaneous administration reduces the absorption of levofloxacin.
-moxifloxacin: simultaneous administration reduces the bioavailability of moxifloxacin by almost 40%, therefore, if simultaneous use is required, it is necessary to ensure the longest possible period between taking moxifloxacin and Sorbifer Durules.
- norfloxacin: simultaneous administration reduces the absorption of norfloxacin by approximately 75%.
- ofloxacin: simultaneous administration reduces the absorption of ofloxacin by approximately 30%.
With the simultaneous use of the drug Sorbifer Durules with the following drugs, dosage adjustment of these drugs may be required. The recommended minimum time interval between taking Sorbifer Durules and these drugs should be at least 2 hours:
- calcium or food supplements containing magnesium carbonate, as well as aluminum hydroxide or calcium, antacids containing magnesium carbonate, together with iron salts form a complex that reduces the absorption of each other.
- captopril: Co-administration reduces the area under the plasma concentration-time curve for captopril by approximately 37%, presumably due to chemical reactions in the gastrointestinal tract.
- zinc: simultaneous use reduces the absorption of zinc salts.
- clodronate: simultaneous use may reduce the absorption of clodronate.
- deferoxamine: with simultaneous use, the absorption of deferoxamine and iron decreases, due to the formation of the compound.
- levodopa: with simultaneous use of ferrous sulfate reduces the bioavailability of single doses of levodopa by about 50%, and single doses of carbidopa by 75%, possibly due to the formation of a chelate compound.
- methyldopa: With simultaneous use, the bioavailability of methyldopa is reduced, possibly due to the formation of a chelate compound.
- penicillamine: the simultaneous use of penicillamine and iron salts reduces their absorption, possibly due to the formation of a chelate compound.
- risedronate: held in vitro studies have shown that preparations containing iron form compounds with risedronate. Although drug interaction studies have not been conducted in vivo, it can be assumed that the simultaneous use of these drugs reduces the absorption of risedronate.
- tetracyclines: with simultaneous use, the absorption of tetracyclines and iron decreases. If simultaneous administration is necessary, the recommended minimum time interval between taking Sorbifer Durules and these drugs should be at least 3 hours. When taken orally, iron inhibits the enterohepatic circulation of oxytetracixin (doxycycline), as well as when administered intravenously.
- thyroid hormones: with the simultaneous use of iron and thyroxine preparations, a decrease in the absorption of thyroxin is possible, which reduces the effectiveness of replacement therapy.
-cimetidine: with simultaneous use, the decrease in gastric acid production caused by cimetidine reduces the absorption of iron. Therefore, the intervals between taking these drugs should be at least 2 hours.
-chloramphenicol: when taken simultaneously, it is possible to delay the clinical effect of iron treatment.
While taking the drug with tea, coffee, eggs, dairy products, wheat flour, porridge or food rich in vegetable fibers, iron absorption may be reduced.
special instructions
Iron preparations can cause poisoning in children. When using the drug, darkening of the stool appears, which has no clinical significance.
The drug is used with caution in gastric and duodenal ulcers, inflammatory bowel diseases (enteritis, diverticulitis, ulcerative colitis, Crohn's disease), chronic liver and kidney diseases.
Comprehensive laboratory and instrumental monitoring of the effectiveness of treatment is recommended every 7-14 days, depending on the course of anemia.
Pregnancy and lactation
The drug can be used during pregnancy and lactation.
Features of the effect of the drug on the ability drive a vehicle or potentially dangerous machinery.
Does not affect.
Overdose
Symptoms: abdominal pain, vomiting and diarrhea (sometimes with blood), fatigue, weakness, hyperthermia, paresthesia, pallor of the skin, cold clammy sweat, acidosis, weak pulse, lowering blood pressure, palpitations. Signs of peripheral circulatory collapse, coagulopathy, hyperthermia, hypoglycemia, liver damage, renal failure, muscle cramps, and coma may occur after 6 to 12 hours.
Treatment: gastric lavage, inside milk and a raw egg, means that provoke vomiting, symptomatic therapy.
If necessary, make a gastric lavage with a solution of deferoxamine at a concentration of 2 g / l, then 5 g of deferoxamine is dissolved in 50-100 ml of water and this solution is left in the stomach.
In severe intoxication: in a state of shock and / or coma and in the event of an increase in serum iron levels (> 90 mmol / l in children, > 142 mmol / l in adults), intensive therapy should be started immediately and deferoxamine should be administered (15 mg / l kg/h IV slowly, maximum 80 mg/kg/24 hours). Too high an infusion rate can lead to hypotension.
In less severe cases of intoxication, deferoxamine can be administered intramuscularly (50 mg/kg, total dose not more than 4 g).
Release form and packaging
30 and 50 tablets are placed in brown glass bottles, sealed with a polyethylene lid and equipped with an accordion shock absorber for glass bottles. The bottle, together with instructions for medical use in the state and Russian languages, is placed in a lithographed cardboard box.
Storage conditions
Store at a temperature not exceeding 25 °C.
Keep out of the reach of children!
Shelf life
Do not use after the expiration date.
Terms of dispensing from pharmacies
Over the counter
Manufacturer
CJSC "PHARMACEUTICAL PLANT EGIS"
1106 BUDAPEST, st. Keresturi, 30-38 HUNGARY
A medicine belonging to the group of antianemic drugs is Sorbifer Durules. Instructions for use prescribes taking pills to compensate for the lack of iron in the body, increase hemoglobin levels, and with anemia.
Release form and composition
Sorbifer is produced in tablets of 160 mg in a carton pack of 30-50 pcs. Each tablet is coated with paraffin, iron oxide, titanium dioxide, hypromellose and macrogol. The main active ingredients are ascorbic acid 60 mg and ferrous sulfate 100 mg.
The drug Sorbifer Durules is available in the dosage form of a tablet for oral administration. They have a round shape, biconvex surface, yellow color. The composition of the drug includes several main active ingredients, their content in one tablet is:
- Ferrous sulfate - 300 mg.
- Vitamin C (ascorbic acid) - 60 mg.
Tablets Sorbifer Durules are packaged in a dark glass bottle in the amount of 30 and 50 pieces. The cardboard pack contains one vial with tablets and instructions for the use of the drug.
Indications for use
What helps Sorbifer? Tablets are prescribed:
- with anemia (due to lack of iron);
- with iron deficiency in the body;
- as a prophylactic in pregnant and lactating women and blood donors.
Instructions for use
Sorbifer is taken orally. Coated tablets should not be divided or chewed. The tablet should be swallowed whole and washed down with at least half a glass of liquid. Adults and adolescents are prescribed 1 tablet 1-2 times a day.
If necessary, for patients with iron deficiency anemia, the dose can be increased to 3-4 tablets per day in 2 divided doses (morning and evening) for 3-4 months (until the iron depot in the body is replenished). During pregnancy and lactation, for the purpose of prevention, 1 tablet per day is prescribed; for treatment appoint 1 tablet 2 times a day (morning and evening).
Treatment should be continued until the optimal hemoglobin level is reached. For further replenishment of the depot, it may be necessary to continue taking the drug for another 2 months.
See also: how to take an analog with a lack of iron in the body -.
pharmachologic effect
Sorbifer Durules is a combined remedy that is used to normalize iron levels in various types of anemia. Due to the action of the active components of the drug, ferrous sulfate and ascorbic acid, this remedy has anti-anemic properties.
The drug is characterized by high absorption with a gradual release of iron ions, which avoids iron overload in the blood and gastrointestinal tract. Vitamin C and ferrous sulfate provide oxygen transport and hemoglobin production.
Ascorbic acid acts as an antioxidant and collagen, which promotes tissue regeneration. Sorbifer Durules is used in the presence of iron absorption disorders in the patient, as well as in its chronic deficiency in the body.
Contraindications
- thrombosis and thrombophlebitis;
- parallel intake of drugs containing iron, problems with the absorption of iron in the body;
- diabetes mellitus and fructose intolerance;
- hemosiderosis and hemochromatosis;
- stenosis of the digestive tract;
- other types of anemia;
- drug allergy;
- children (up to 12 years old);
- urolithiasis and other serious kidney diseases.
In case of inflammation and peptic ulcer of the gastrointestinal tract, the remedy is used only for its intended purpose and under the supervision of a physician.
Side effects
Against the background of taking Sorbifer Durules tablets, a number of pathological negative reactions from various organs and systems may develop:
- Nervous system - dizziness, periodic headache, general weakness.
- Allergic reactions - a rash on the skin, itching, specific pathological changes in the form of swelling and rash, resembling a nettle burn.
- Digestive system - nausea, periodic vomiting, pain in the abdomen, stool disorders (constipation or diarrhea). Rarely, ulcerative lesions of the walls of the stomach, duodenum, as well as narrowing (stenosis) of the esophagus can develop.
Rarely, hyperthermia of the skin was noted. Negative pathological reactions are dose-dependent. With their development, the need to stop taking Sorbifer Durules tablets or adjust the dosage is determined by the attending physician.
Children, during pregnancy and lactation
It is possible to use the drug Sorbifer Durules during pregnancy and lactation according to indications. The drug is contraindicated in children and adolescents under 12 years of age.
special instructions
During treatment, it is possible to change the color of feces to dark, which is due to the release of unabsorbed iron. Such a reaction is a physiological norm, does not require dosage adjustment or drug withdrawal.
drug interaction
Do not combine the drug with ciprofloxacin, norfloxacin, levofloxacin, ofloxacin and Moxifloxacin.
The combination of calcium and magnesium supplements, clodronate, cimetidine, levodopa, zinc, desferoxamine, methyldopa, tetracycline, penicillinamine, thyroid hormones, pancreatin, ethanol and tocopherol with Sorbifer is not recommended. The interval between taking medications should be less than two hours.
The combination of the drug with ascorbic acid can lead to an overdose of iron.
The process of drug absorption worsens when combined with milk, eggs, tea, coffee, juices, bread, foods rich in vegetable fibers. Oral contraceptives and chloramphenicol also negatively affect absorption.
Sorbifer's analogs
According to the structure, analogues are determined:
- Vitrum Superstress.
- Enfamil with iron.
- Biovital elixir.
- Ferro Folgamma.
- Ferretab.
- Pikovit Complex.
- Likferr 100.
- Maltofer Fall.
- Ferronal.
- Biofer.
- Kids Junior.
- Special dragee Merz.
- Totem.
- Ferronal 35.
- Gino Tardiferon.
- Maltofer.
- Stress formula with iron.
- Ferrum Lek.
- Heferol.
- Multi tabs Active.
Analogues are intended for the treatment of iron deficiency:
- Enfamil Premium 2.
- Vitrum Circus.
- Ferrogradum.
- Fenuls 100.
- Aloe syrup with iron.
- Tardiferon.
- Actiferrin compositum.
- Ferroplex.
- Hemopher.
- Ferrinat.
- Venofer.
- Ferlatum.
Holiday conditions and price
The average cost of Sorbifer (tablets No. 30) in Moscow is 387 rubles. Released by prescription.
Sorbifer Durules should be stored out of the reach of children at a temperature of 15 ... 25 C. The shelf life of the drug is 3 years.
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The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!
Sorbifer Durules
Sorbifer Durules- an antianemic combined drug, which combines ferrous sulfate with ascorbic acid. The pronounced therapeutic effect of the drug in anemia (anemia) is ensured precisely due to the combined action of its components: ferrous sulfate replenishes iron deficiency in the body, and vitamin C increases its absorption in the digestive tract.Durules- a special manufacturing technology of the drug, which allows iron ions to be evenly and gradually released in the intestine not under the action of digestive juices, but as a result of peristalsis (wave-like movements of the intestinal walls).
Such a gradual (over 6 hours) release of iron ions prevents the creation of an increased amount of them in the digestive organs and prevents the irritating effect of iron ions on the mucous membrane of the digestive tract.
The absorption of the drug in the small intestine, thanks to this technology, is high, 30% higher than that of others iron preparations. It is Ascorbic acid that increases its absorption.
Release form
Coated tablets of 30 and 50 pieces in a vial. 1 tablet of Sorbifer Durules contains 100 mg of iron and 60 mg of vitamin C.Instructions for use Sorbifer Durules
Indications for use
- Treatment and prevention of iron deficiency anemia caused by various causes;
- prolonged, heavy bleeding (uterine, gastrointestinal, nasal);
- replenishment of iron deficiency with an increased need for it (after serious illness, during breastfeeding, during pregnancy, intensive growth in adolescence, with constant donation);
- replenishment of iron deficiency in violation of its absorption (with prolonged diarrhea);
- insufficient, malnutrition.
It is advisable to use Sorbifer Durules only in case of iron deficiency anemia. With anemia caused by another reason, the drug should not be prescribed.
Before starting treatment, iron-binding activity and the level of iron in the blood are determined.
Contraindications
1. High iron content:- hemochromatosis (hereditary disorder of iron metabolism);
- hemosiderosis (a disease associated with increased breakdown of red blood cells).
- aplastic anemia (inhibition of bone marrow hematopoiesis);
- hemolytic anemia (associated with increased destruction of red blood cells);
- lead anemia (occurs with lead poisoning);
- sideroblastic anemia (the level of iron is sufficient, but the body cannot use it);
4. Condition after removal of the stomach;
5. Age up to 12 years;
6. Narrowing of the lumen of the esophagus or other parts of the digestive tract;
7. Intolerance to any component of the drug.
Sorbifer should be used with caution in Crohn's disease (inflammatory process of various parts of the digestive tract), diverticulitis, peptic ulcer (12 duodenal ulcer, stomach or large intestine), inflammation of the small intestine (enteritis).
Side effects
During treatment with Sorbifer, vomiting, abdominal pain, nausea, an unpleasant aftertaste in the mouth, stool disorders (constipation or diarrhea), loss of appetite may occur. These manifestations may increase with increasing doses up to 400 mg.Extremely rarely, such adverse reactions as ulceration of the esophagus, narrowing of the esophagus, headache, fever of the skin, weakness, dizziness, skin allergic manifestations (rashes, skin itching) are observed.
Treatment with Sorbifer
How to take Sorbifer?The tablet should be swallowed whole, without chewing, half an hour before meals; take the tablet with water (at least 100 ml).
Against the background of treatment with Sorbifer, as well as other iron-containing drugs, there is a black color of feces. Its appearance should not cause concern to the patient.
Reduce the absorption of Sorbifer egg yolk, tea, dairy products.
Dosage of Sorbifer
The usual therapeutic dose of Sorbifer is 1 tablet or 100 mg 2 times a day. With the appearance of side effects, the dose of the drug is reduced to 1 tablet per day.
Depending on the severity of anemia, the dose may be increased to 300-400 mg per day (3-4 tablets) in 2 divided doses.
The duration of the course of treatment is determined by the doctor. During treatment, a complete blood count and serum iron levels are monitored. After normalization of indicators, treatment is usually extended by 2 months to create a supply of iron in the body. In severe anemia, the course can be extended up to 3-6 months.
The prophylactic and maintenance dose is 100 mg (1 tablet) per day.
The simultaneous use of Sorbifer with other iron-containing drugs should be avoided (to avoid overdose). In case of an overdose, the following symptoms may appear: vomiting, abdominal pain, diarrhea with blood, weakness, pallor of the skin, lowering blood pressure, weak pulse, palpitations, fever, smell of acetone from the mouth. In severe cases of overdose, kidney and liver failure, low blood sugar, convulsions and loss of consciousness may occur.
Sorbifer for children
Sorbifer Durules can be prescribed to children over 12 years of age at a daily dosage of 3 mg per 1 kg of body weight.Clinical data on the use of Sorbifer in children under 12 years of age are not available.
Sorbifer during pregnancy
During pregnancy, almost all women have varying degrees of iron deficiency and the development of anemia, which is dangerous for both the woman and the child. Therefore, during the II and III trimesters of pregnancy, iron preparations are prescribed to all pregnant women for prophylactic purposes. The drug of choice among iron-containing drugs for pregnant women is most often Sorbifer Durules, which can provide a fairly rapid increase in the level of iron in a woman's body. For prophylactic purposes, Sorbifer is prescribed 1 tablet per day.
If anemia is detected in a pregnant woman for therapeutic purposes, Sorbifer is prescribed 1 tablet 1-2 times a day (depending on the severity of anemia). As a rule, in the III trimester of pregnancy and for the period of the thyroid gland).
Sorbifer's analogs
Analogues of the drug Sorbifer Durules for the active substance are Ferroplex, Fenyuls 100.Analogues of the drug for therapeutic action: Actiferrin compositum, Biofer, Hemofer, Venofer, Gino Tardiferon, Totem, Ferretab, Ferrogradumet, Ferrinat, Heferol, Ferronal, etc.