In what cases are Gynoflor E vaginal tablets used and how do they work? Gynoflor analogues are cheaper Gynoflor analogues are cheaper
pharmachologic effect
Both active substances that are part of the preparation Gynoflor E, estriol and lactobacilli Lactobacillus acidophilus, are involved in the physiological mechanism for maintaining normal vaginal biocenosis.
lactobacillus acidophilus- one of the dominant microorganisms of the vagina of a healthy woman, having antagonistic activity against pathogenic and conditionally pathogenic microorganisms.
Estriol- is a short-acting estrogen, has a protective trophic effect on the vaginal epithelium and has no systemic effect on the woman's body. The proliferating mature vaginal epithelium accumulates glycogen necessary for the functioning of lactobacilli, which, in turn, produce lactic acid, maintaining the acidic environment of the vagina (pH 3.8-4.5), which creates unfavorable conditions for the colonization and development of pathogenic microorganisms. In addition to lactic acid, Lactobacillus acidophilus produce hydrogen peroxide and bacteriocins, which also inhibit the development of pathogenic and conditionally pathogenic microorganisms.
Changes in the physiological vaginal flora occur due to various factors: local or systemic use of antibacterial drugs, incl. due to vaginal infections, systemic diseases, poor hygiene. In these cases, the number of lactobacilli may decrease significantly. Intravaginal application of Gynoflor E improves the condition of the vaginal epithelium and restores its normal flora. Lactose, which is found in vaginal tablets as a filler, can also be fermented by lactobacilli into lactic acid.
The vaginal epithelium becomes thinner and can be damaged during hormonal disorders, in connection with which Gynoflor E can be used in postmenopausal women, weakening its local symptoms (itching, burning, vaginal dryness, pain during intercourse), contributing to the normalization of the vaginal and urethral epithelium, reducing the frequency of dystrophic inflammatory conditions.
It has been shown in vitro that Lactobacillus acidophilus leads to the necessary decrease in pH within a few hours, and estriol, with a treatment duration of 6-12 days, provides a proliferative trophic effect on the vaginal epithelium.
Pharmacokinetics
When the drug is injected into the vagina, lyophilized bacteria and estriol are released.
The absorption of estriol from Gynoflor E was studied in postmenopausal women. After repeated use of the drug, its plasma concentration corresponds to the concentration of endogenous unbound estriol. After the 12th day of using vaginal tablets during treatment with Gynoflor E (1 time per day), the maximum concentration of unbound estriol in the blood plasma does not differ from the initial one, which indicates the absence of systemic absorption.
The use of the drug does not affect the concentration of estrone and estradiol in the blood plasma, since estriol is the end product of their metabolism.
Indications
- restoration of the flora of Lactobacillus acidophilus after local and / or systemic treatment with antibiotics or other chemotherapeutic agents;
- estrogen-dependent atrophic vaginitis in postmenopause, including in combination with hormone replacement therapy (HRT);
- bacterial vaginosis.
Dosing regimen
Vaginal tablets should be inserted deep into the vagina in the evening before going to bed, preferably in the supine position, with the legs slightly bent at the knees.
To restore the flora of Lactobacillus acidophilus after topical and / or systemic treatment with antibiotics or other chemotherapeutic agents, as well as in the treatment of bacterial vaginosis: 1-2 vaginal tablets daily for 6-12 days.
In the treatment of estrogen-dependent atrophic vaginitis in postmenopausal women: 1 vaginal tablet daily for 6-12 days, then the maintenance dose is 1 vaginal tablet 1-2 times a week.
Side effect
There may be a burning sensation (heat) in the vagina, rarely redness and itching of the vulva and vagina.
Contraindications for use
- hypersensitivity to the drug or its components;
- malignant estrogen-dependent neoplasms, incl. mammary glands, uterus and vagina (diagnosed, in history, and if they are suspected);
- endometriosis (suspected or diagnosed);
- bleeding from the vagina of unknown etiology;
- use in girls before the onset of sexual activity;
- untreated endometrial hyperplasia.
Use during pregnancy and lactation
Use in the first trimester of pregnancy is undesirable. Perhaps the use of the drug Gynoflor E in the II-III trimesters of pregnancy and lactation. Undesirable effects of lactobacilli and estriol on pregnancy and the condition of the fetus / newborn were not found. However, long-term clinical studies on the effect of estriol on the fetus have not been conducted.
Use in children
It is contraindicated for use in girls before the onset of sexual activity.
Overdose
An overdose of the drug was not observed.
drug interaction
Lactobacillus acidophilus is sensitive to numerous antibacterial drugs (topical or systemic). Concomitant treatment with such agents may lead to a decrease in the effectiveness of Gynoflor E.
Terms of dispensing from pharmacies
Over the counter.
Terms and conditions of storage
Store at a temperature of 2 to 8°C. Do not freeze! Keep out of the reach of children. Shelf life - 3 years.
special instructions
Gynoflor E contains components that may not completely dissolve, the remains of a vaginal tablet can sometimes be found on underwear. This does not affect the effectiveness of the drug.
In rare cases, with vaginal dryness, the vaginal tablet may not dissolve. To prevent such cases, the tablet can be moistened with a small amount of ordinary water before administration - this will contribute to its faster dissolution. Patients are advised to use pads.
Influence on the ability to drive a car and other mechanisms
Gynoflor E does not affect the ability to drive vehicles and mechanisms.
Gynoflor E: instructions for use and reviews
Latin name: Gynoflor E
ATX code: G02CX
Active substance: lactobacillus acidophilus (lyophilisate) and estriol
Manufacturer: Medinova Ltd. Switzerland for OOO Invar, Russia
Description and photo update: 22.10.2018
Gynoflor E is a combined drug for regulating the balance of the vaginal microflora.
Release form and composition
Dosage form of the drug - vaginal tablets: oval, biconvex, from light beige to white, inclusions are allowed (6 pcs in blister packs; in a carton pack 1 or 2 packs).
Composition per 1 tablet:
- active ingredients: acidophilic lactobacilli (in the form of a lyophilisate) ≥ 100 million viable bacteria - 50,000 mcg; estriol - 30 mcg;
- auxiliary ingredients: lactose monohydrate, sodium carboxymethyl starch, magnesium stearate, microcrystalline cellulose, sodium dihydrogen phosphate.
Pharmacological properties
Pharmacodynamics
As part of Gynoflor E, as active substances, there are: a short-acting female sex hormone of the estrogen class - estriol; live bacteria that dominate the vagina of a healthy woman, having antagonistic activity against a wide range of pathogenic and conditionally pathogenic microflora, supporting and normalizing the vaginal biocenosis - acidophilic lactobacilli.
Estriol has a protective trophic effect on the vaginal epithelium and does not systemically affect the woman's body. The mature proliferating epithelial layer of the vagina accumulates glycogen, which is necessary for the functioning of lactobacilli that produce lactic acid to maintain the acidic environment of the vagina (pH values 3.8–4.5), as well as creating unfavorable conditions for the development and colonization of pathogenic microflora. Together with lactic acid, acidophilic lactobacilli produce bacteriocins and hydrogen peroxide, which also act depressingly on the development of pathogenic and conditionally pathogenic microflora.
Modification of the normal physiological environment of the vagina can occur due to the use of local or systemic antibacterial agents for the treatment of vaginal infections or systemic diseases, as well as non-compliance with personal hygiene rules. In such cases, a significant decrease in the number of natural lactobacilli is likely. When administered intravaginally, Gynoflor E normalizes the condition of the vaginal epithelium and restores its natural microflora. Contained as a filler in vaginal tablets, lactose is able to be fermented by lactobacilli into lactic acid.
With hormonal disorders, the epithelial layer of the vagina can become thinner and damaged, so Gynoflor E is also recommended for postmenopausal women to relieve local symptoms: itching, burning, vaginal dryness, pain during intercourse. The drug contributes to the normalization of the state of the epithelium of the vagina and urethra, reduces the frequency of dystrophic inflammatory processes.
In vitro studies have shown that acidophilic lactobacilli lower the pH to normal within a few hours. Estriol, during therapy for 6-12 days, provides a proliferative trophic effect on the epithelial layer of the vagina.
Pharmacokinetics
With the introduction of the Gynoflor E tablet into the vagina, lyophilized acidophilic lactobacilli and estriol are released.
The study of the absorption of estriol from Gynoflor E was carried out when the drug was used by women in the postmenopausal period. The concentration of estriol in plasma after repeated use corresponds to the level of endogenous unbound estriol. After 12 days of treatment with Gynoflor E vaginal tablets, provided they are used once a day, the maximum concentration (Cmax) in the blood plasma of unbound estriol does not differ from the initial one, which is an indicator of the absence of systemic absorption.
The use of the drug does not affect the plasma concentration of the sex hormones present in the body of a woman - estrone and estradiol, since estriol is the end product of their metabolism.
Indications for use
According to the instructions, Gynoflor E is recommended for use to restore normal vaginal microflora after the use of antibiotics and other antimicrobials for local / systemic treatment of vaginal infections (bacterial vaginosis, nonspecific vulvovaginitis), urogenital infections and sexually transmitted diseases. In the postmenopausal period, the drug is used in combination with hormone replacement therapy (HRT) for estrogen-dependent atrophic vaginitis.
Contraindications
- vaginal bleeding of unknown etiology;
- malignant estrogen-dependent tumors, including neoplasms of the breast, ovaries, uterus or vagina (in history, diagnosed, and also if they are suspected);
- endometriosis (suspected/diagnosed);
- untreated endometrial hyperplasia;
- increased individual sensitivity to any of the components of the drug.
Gynoflor E is contraindicated before the onset of sexual activity.
Instructions for use Gynoflor E: method and dosage
The tablets are intended for intravaginal (deep) administration. The procedure is recommended to be carried out in the evening, before going to bed, preferably in the supine position, legs slightly bent at the knees.
Dosing regimen according to indications:
- restoration of the normal microflora of the vagina: inject 1-2 tablets daily, course 6-12 days;
- treatment of estrogen-dependent atrophic vaginitis in the postmenopausal period: administer 1 tablet daily, course 6–12 days; maintenance dose - 1 tablet 1-2 times a week.
Side effects
When using Gynoflor E in the vagina, a burning sensation is possible, in rare cases, redness of the vulva and vagina and vulvovaginal itching.
Overdose
No data.
special instructions
The composition of the drug Gynoflor E contains components that cannot dissolve without a trace, so sometimes you can find the remains of a vaginal tablet on underwear. This fact does not affect the effectiveness of the drug.
In exceptional cases, with excessive dryness of the vagina, the tablet may not dissolve. To prevent such a situation, it can be moistened with a small amount of plain water before administration - this will contribute to faster dissolution. During therapy, patients are advised to use sanitary napkins.
Influence on the ability to drive vehicles and complex mechanisms
The use of Gynoflor E does not affect the ability to drive vehicles and complex mechanisms.
Use during pregnancy and lactation
An undesirable effect of lactobacilli and estriol on the course of pregnancy and the condition of the fetus / newborn was not found. But long-term clinical studies on the effect of estriol on the fetus have not been conducted.
It is undesirable to use Gynoflor E in the first trimester of pregnancy. It is allowed to use the drug in the II-III trimesters of pregnancy and during breastfeeding, after consultation with a specialist.
drug interaction
The simultaneous use of Gynoflor E with antibacterial drugs is not recommended, since acidophilic lactobacilli are sensitive to most antibacterial drugs for local or systemic therapy. Their simultaneous use can significantly reduce the effectiveness of treatment.
Analogues
The analogues of Gynoflor E are: Vagisan, Vagilak, Vaginorm-S, Laktogin, Laktovag, Ecofemin, etc.
Terms and conditions of storage
Store at 2-8°C. Do not freeze. Keep away from children.
Shelf life - 3 years.
Instructions for use. Contraindications and release form.
INSTRUCTIONS
to use the remedy
Gynoflor E
Release form
Vaginal tablets.
Package
6 pcs.
Pharmacotherapeutic group
Estrogen + eubiotic
ATX code:G02CX
Pharmacological properties
Pharmacodynamics
The active substances that make up the drug GynoflorE, estriol and acidophilic lactobacilli, are involved in the physiological mechanism for maintaining a normal vaginal biocenosis.
Lactobacillus acidophilus is one of the dominant microorganisms of the vagina of a healthy woman, which has antagonistic activity against pathogenic and opportunistic microorganisms.
Estriol is a female sex hormone, a short-acting estrogen. It has a protective trophic effect on the vaginal epithelium and has no systemic effect on the woman's body. The proliferating mature vaginal epithelium accumulates glycogen, which is necessary for the functioning of lactobacilli, which, in turn, produce lactic acid, maintaining the acidic environment of the vagina (pH 3.8-4.5), which creates unfavorable conditions for the colonization and development of pathogenic microorganisms. In addition to lactic acid, acidophilic lactobacilli produce hydrogen peroxide and bacteriocins, which also inhibit the development of pathogenic and opportunistic microorganisms.
Changes in the physiological flora of the vagina occur due to various factors: local or systemic use of antibacterial drugs, incl. due to vaginal infections, systemic diseases, poor hygiene. In these cases, the number of lactobacilli can be significantly reduced. Intravaginal use of the drug Gynoflor E improves the condition of the vaginal epithelium and restores its normal flora. Lactose, which is found in vaginal tablets as a filler, can also be fermented by lactobacilli into lactic acid.
The epithelium of the vagina becomes thinner and can also be damaged in case of hormonal disorders, in connection with which the drug Gynoflor E can be used in postmenopausal women to relieve its local symptoms (itching, burning, dryness in the vagina, pain during intercourse), contributing to the normalization of the condition of the epithelium of the vagina and urethra, reducing the frequency of dystrophic inflammatory conditions.
It has been shown in vitro that acidophilic lactobacilli within a few hours lead to the necessary decrease in pH. Estriol, with a duration of treatment of 6-12 days, provides a proliferative trophic effect on the vaginal epithelium.
Pharmacokinetics
When the drug is injected into the vagina, lyophilized bacteria and estriol are released.
Absorption of estriol from Gynoflor E was studied in postmenopausal women. After repeated use of the drug, the concentration of estriol in plasma corresponds to the concentration of endogenous unbound estriol. After the 12th day of using vaginal tablets during treatment with Gynoflor E (1 time per day), the maximum concentration of unbound estriol in the blood plasma does not differ from the initial one, which indicates the absence of systemic absorption.
The use of the drug does not affect the concentration in the blood plasma of the sex hormones present in the body of a woman - estrone and estradiol, since estriol is the end product of their metabolism.
Indications
Restoration of the normal microflora of the vagina after local and / or systemic use of antibiotics or antimicrobials (including vaginal infections: bacterial vaginosis, nonspecific vulvovaginitis; urogenital infections and sexually transmitted diseases).
Estrogen-dependent atrophic vaginitis in postmenopause, including in combination with hormone replacement therapy (HRT).
Contraindications
hypersensitivity to the drug or its components;
malignant estrogen-dependent neoplasms, incl. mammary glands, uterus, ovaries or vagina (diagnosed, in history, and if they are suspected);
endometriosis (suspected or diagnosed);
bleeding from the vagina of unknown etiology;
use in girls before sexual activity;
untreated endometrial hyperplasia.
Use during pregnancy and lactation
Use in the first trimester of pregnancy is undesirable. It is possible to use the drug Gynoflor E in the II-III trimesters of pregnancy and during breastfeeding. Undesirable effects of lactobacilli and estriol on pregnancy and the condition of the fetus / newborn were not found. However, long-term clinical studies on the effect of estriol on the fetus have not been conducted.
special instructions
The drug Gynoflor E contains components that may not dissolve completely, the remains of a vaginal tablet can sometimes be found on underwear. This does not affect the effectiveness of the drug.
In rare cases, with vaginal dryness, the vaginal tablet may not dissolve. To prevent such cases, the tablet can be moistened with a small amount of ordinary water before administration - this will contribute to its faster dissolution. Patients are advised to use pads.
Compound
Composition for 1 vaginal tablet:
Active substances: Lactobacillus acidophilus (lyophilisate) 50.00 mg (not less than 100 million viable bacteria), estriol 0.03 mg;
Excipients: lactose monohydrate 625.6 mg, microcrystalline cellulose 183.7 mg, magnesium stearate 6.67 mg, sodium carboxymethyl starch 30 mg, sodium dihydrogen phosphate 4 mg.
Description
Tablets are oval, biconvex from white to light beige with patches.
Dosage and administration
Vaginal tablets should be inserted deep into the vagina in the evening before going to bed, preferably in the supine position, with the legs slightly bent at the knees.
To restore the normal microflora of the vagina after local and / or systemic use of antibiotics or other antimicrobial drugs (including vaginal infections: bacterial vaginosis, nonspecific vulvovaginitis, urogenital infections and sexually transmitted diseases): 1-2 vaginal tablets daily for 6-12 days.
In the treatment of estrogen-dependent atrophic vaginitis in postmenopausal women: 1 vaginal tablet daily for 6-12 days, then the maintenance dose is 1 vaginal tablet 1-2 times a week.
Side effects
There may be a burning sensation (heat) in the vagina, rarely redness and itching of the vulva and vagina.
drug interaction
Lactobacillus acidophilus is sensitive to numerous antibacterial drugs (topical or systemic use). Concomitant treatment with such drugs may lead to a decrease in the effectiveness of the drug GynoflorE. Therefore, its simultaneous use with antibacterial drugs is not recommended. The use of the drug Gynoflor E together with spermicidal agents is not recommended.
Overdose
An overdose of the drug was not observed.
Storage conditions
Store at a temperature of 2 to 8 °C. Do not freeze!
Keep out of the reach of children.
Best before date
3 years. Do not use after the expiration date.
This page contains a list of all Gynoflor E analogues by composition and indications for use. A list of cheap analogues, and you can also compare prices in pharmacies.
- The cheapest analogue of Gynoflor E:
- The most popular analogue of Gynoflor E:
- ATH classification: Other means used in gynecology
- Active ingredients / composition: lactobacillus acidophilus, estriol
Cheap analogues of Gynoflor E
| # | Name | Price in Russia | Price in Ukraine |
|---|---|---|---|
| 1 | 20 rub | 27 UAH | |
| 2 | Analogue in composition and indication | 300 rub | 109 UAH |
| 3 | beta alanine Analogue in composition and indication | 300 rub | 269 UAH |
| 4 | Analogue in composition and indication | 401 rub | 350 UAH |
| 5 | sigetin Analogue in composition and indication | 416 rub | 65 UAH |
When calculating the cost cheap analogues of Gynoflor E the minimum price was taken into account, which was found in the price lists provided by pharmacies
Popular analogues of Gynoflor E
| # | Name | Price in Russia | Price in Ukraine |
|---|---|---|---|
| 1 | Analogue in composition and indication | 14718 rub | -- |
| 2 | Analogue in composition and indication | 630 rub | 700 UAH |
| 3 | Soya Analogue in composition and indication | 1790 rub | 90 UAH |
| 4 | homeopathic potencies of various substances Analogue in composition and indication | 20 rub | 27 UAH |
| 5 | Analogue in composition and indication | -- | -- |
The list of drug analogues based on the statistics of the most requested drugs
All analogues of Gynoflor E
Analogues in composition and indications for use
| Name | Price in Russia | Price in Ukraine |
|---|---|---|
| Calamus vulgaris, Periwinkle, Oregano, St. John's wort, Calendula officinalis, Shepherd's purse, Chamomile officinalis, Yarrow, Common celandine | -- | 28 UAH |
| Soya | 1790 rub | 90 UAH |
| -- | -- | |
| 14718 rub | -- | |
| 630 rub | 700 UAH | |
| conium, thuja, hydrastis, calcium fluoratum | 401 rub | 350 UAH |
| beta alanine | 300 rub | 269 UAH |
| human placenta hydrolyzate | 13900 rub | -- |
| indole-3-carbinol | 853 rub | 1180 UAH |
| beta alanine | 1440 rub | 79 UAH |
| indole 3 carbinol, catechin epigallacts | -- | -- |
| atosiban | 1886 rub | 1048 UAH |
| Amino acid | -- | 58 UAH |
| Lactobacillus rhamnosus | -- | 101 UAH |
| 2053 rub | 39 UAH | |
| Lactobacillus plantarum | -- | 52 UAH |
| homeopathic potencies of various substances | 20 rub | 27 UAH |
| sigetin | 416 rub | 65 UAH |
| nitric acid, acetic acid, zinc nitrate, oxalic acid dihydrate | 712 rubles | 222 UAH |
| Calendula officinalis, Meadowsweet, Toadflax, Parsley, Bedstraw, Celery | 2970 rub | 123 UAH |
| homeopathic potencies of various substances | 2290 rub | 196 UAH |
| homeopathic potencies of various substances | -- | 97 UAH |
| calendula officinalis | 1290 rub | 92 UAH |
| Lactobacillus acidophilus, Lactobacillus delbrueckii, Lactobacillus rhamnosus, Streptococcus thermophilus | 300 rub | 109 UAH |
| common prutnyak | 1449 rub | 187 UAH |
The above list of analogues of drugs, which indicates Gynoflor E substitutes, is the most suitable, since they have the same composition of active ingredients and match the indications for use
Different composition, may coincide in indication and method of application
| Name | Price in Russia | Price in Ukraine |
|---|---|---|
| hexoprenaline | 25 rub | 30 UAH |
| 159 rub | 91 UAH | |
| -- | 81 UAH | |
| bromocriptine | -- | 73 UAH |
| cabergoline | -- | 145 UAH |
| cabergoline | 560 rub | 220 UAH |
| -- | -- | |
| 295 rub | -- | |
| quinagolide | 995 rub | 290 UAH |
| yarrow herb thick extract, polyphytic oil Kyzyl may | -- | -- |
| benzydamine | 256 rub | 28 UAH |
To compile a list of cheap analogues of expensive drugs, we use the prices provided by more than 10,000 pharmacies throughout Russia. The database of drugs and their analogues is updated daily, so the information provided on our website is always up-to-date as of the current day. If you have not found the analogue you are interested in, please use the search above and select the medicine you are interested in from the list. On the page of each of them you will find all possible options for analogues of the desired medicine, as well as prices and addresses of pharmacies in which it is available.
How to find a cheap analogue of an expensive medicine?
To find an inexpensive analogue of a drug, a generic or a synonym, we first of all recommend paying attention to the composition, namely, to the same active ingredients and indications for use. The same active ingredients of the drug will indicate that the drug is a synonym for the drug, a pharmaceutical equivalent or a pharmaceutical alternative. However, do not forget about the inactive components of similar drugs, which can affect safety and efficacy. Do not forget about the advice of doctors, self-medication can harm your health, so always consult a doctor before using any medication.Gynoflor E price
On the websites below you can find prices for Gynoflor E and find out about availability at a pharmacy nearbyGynoflor E instructions
INSTRUCTIONS
to use the remedy
Gynoflor E
Release form
Vaginal tablets.
Package
6 pcs.
Pharmacotherapeutic group
Estrogen + eubiotic
ATX code:G02CX
Pharmacological properties
Pharmacodynamics
The active substances that make up the drug GynoflorE, estriol and acidophilic lactobacilli, are involved in the physiological mechanism for maintaining a normal vaginal biocenosis.
Lactobacillus acidophilus is one of the dominant microorganisms of the vagina of a healthy woman, which has antagonistic activity against pathogenic and opportunistic microorganisms.
Estriol is a female sex hormone, a short-acting estrogen. It has a protective trophic effect on the vaginal epithelium and has no systemic effect on the woman's body. The proliferating mature vaginal epithelium accumulates glycogen, which is necessary for the functioning of lactobacilli, which, in turn, produce lactic acid, maintaining the acidic environment of the vagina (pH 3.8-4.5), which creates unfavorable conditions for the colonization and development of pathogenic microorganisms. In addition to lactic acid, acidophilic lactobacilli produce hydrogen peroxide and bacteriocins, which also inhibit the development of pathogenic and opportunistic microorganisms.
Changes in the physiological flora of the vagina occur due to various factors: local or systemic use of antibacterial drugs, incl. due to vaginal infections, systemic diseases, poor hygiene. In these cases, the number of lactobacilli can be significantly reduced. Intravaginal use of the drug Gynoflor E improves the condition of the vaginal epithelium and restores its normal flora. Lactose, which is found in vaginal tablets as a filler, can also be fermented by lactobacilli into lactic acid.
The epithelium of the vagina becomes thinner and can also be damaged in case of hormonal disorders, in connection with which the drug Gynoflor E can be used in postmenopausal women to relieve its local symptoms (itching, burning, dryness in the vagina, pain during intercourse), contributing to the normalization of the condition of the epithelium of the vagina and urethra, reducing the frequency of dystrophic inflammatory conditions.
It has been shown in vitro that acidophilic lactobacilli within a few hours lead to the necessary decrease in pH. Estriol, with a duration of treatment of 6-12 days, provides a proliferative trophic effect on the vaginal epithelium.
Pharmacokinetics
When the drug is injected into the vagina, lyophilized bacteria and estriol are released.
Absorption of estriol from Gynoflor E was studied in postmenopausal women. After repeated use of the drug, the concentration of estriol in plasma corresponds to the concentration of endogenous unbound estriol. After the 12th day of using vaginal tablets during treatment with Gynoflor E (1 time per day), the maximum concentration of unbound estriol in the blood plasma does not differ from the initial one, which indicates the absence of systemic absorption.
The use of the drug does not affect the concentration in the blood plasma of the sex hormones present in the body of a woman - estrone and estradiol, since estriol is the end product of their metabolism.
Indications
Restoration of the normal microflora of the vagina after local and / or systemic use of antibiotics or antimicrobials (including vaginal infections: bacterial vaginosis, nonspecific vulvovaginitis; urogenital infections and sexually transmitted diseases).
Estrogen-dependent atrophic vaginitis in postmenopause, including in combination with hormone replacement therapy (HRT).
Contraindications
hypersensitivity to the drug or its components;
malignant estrogen-dependent neoplasms, incl. mammary glands, uterus, ovaries or vagina (diagnosed, in history, and if they are suspected);
endometriosis (suspected or diagnosed);
bleeding from the vagina of unknown etiology;
use in girls before sexual activity;
untreated endometrial hyperplasia.
Use during pregnancy and lactation
Use in the first trimester of pregnancy is undesirable. It is possible to use the drug Gynoflor E in the II-III trimesters of pregnancy and during breastfeeding. Undesirable effects of lactobacilli and estriol on pregnancy and the condition of the fetus / newborn were not found. However, long-term clinical studies on the effect of estriol on the fetus have not been conducted.
special instructions
The drug Gynoflor E contains components that may not dissolve completely, the remains of a vaginal tablet can sometimes be found on underwear. This does not affect the effectiveness of the drug.
In rare cases, with vaginal dryness, the vaginal tablet may not dissolve. To prevent such cases, the tablet can be moistened with a small amount of ordinary water before administration - this will contribute to its faster dissolution. Patients are advised to use pads.
Compound
Composition for 1 vaginal tablet:
Active substances: Lactobacillus acidophilus (lyophilisate) 50.00 mg (not less than 100 million viable bacteria), estriol 0.03 mg;
Excipients: lactose monohydrate 625.6 mg, microcrystalline cellulose 183.7 mg, magnesium stearate 6.67 mg, sodium carboxymethyl starch 30 mg, sodium dihydrogen phosphate 4 mg.
Description
Tablets are oval, biconvex from white to light beige with patches.
Dosage and administration
Vaginal tablets should be inserted deep into the vagina in the evening before going to bed, preferably in the supine position, with the legs slightly bent at the knees.
To restore the normal microflora of the vagina after local and / or systemic use of antibiotics or other antimicrobial drugs (including vaginal infections: bacterial vaginosis, nonspecific vulvovaginitis, urogenital infections and sexually transmitted diseases): 1-2 vaginal tablets daily for 6-12 days.
In the treatment of estrogen-dependent atrophic vaginitis in postmenopausal women: 1 vaginal tablet daily for 6-12 days, then the maintenance dose is 1 vaginal tablet 1-2 times a week.
Side effects
There may be a burning sensation (heat) in the vagina, rarely redness and itching of the vulva and vagina.
drug interaction
Lactobacillus acidophilus is sensitive to numerous antibacterial drugs (topical or systemic use). Concomitant treatment with such drugs may lead to a decrease in the effectiveness of the drug GynoflorE. Therefore, its simultaneous use with antibacterial drugs is not recommended. The use of the drug Gynoflor E together with spermicidal agents is not recommended.
Overdose
An overdose of the drug was not observed.
Storage conditions
Store at a temperature of 2 to 8 °C. Do not freeze!
Keep out of the reach of children.
Best before date
3 years. Do not use after the expiration date.
The drug Gynoflor E does not have analogues with the same active substance (a combination of acidophilic lactobacilli with estriol), but you can choose drugs that are similar in mechanism of action (maintaining normal vaginal biocenosis).
Cheap analogues of Gynoflor E:
1) Galavit candles
2) Hexicon vaginal suppositories
3) Gynecohel homeopathic drops
4) Gormel SN homeopathic drops
5) Depanthol vaginal suppositories
6) Klimadinon and Klimadinon Uno tablets
7) Klimakt-Hel homeopathic tablets
8) Klimalanin tablets
9) Klioron vaginal suppositories
10) Kliofit elixir
11) Macmirror tablets, capsules, cream
12) Mammoleptin capsules
13) Mamoclam tablets
14) Mastodinone drops and tablets
15) Osarbon vaginal suppositories
16) Povidin vaginal suppositories
17) Povidone-Iodine vaginal suppositories
18) Remens homeopathic drops
19) Remens homeopathic tablets
20) Saflab-Kit tablets
21) Sagenite capsules and tablets
22) Qi-clim pills
23) Femaflor capsules
24) Furazolidone tablets
25) Flurenizide vaginal suppositories
26) Chlorhexidine vaginal suppositories
27) Triogynal vaginal capsules
26) Eucolek vaginal suppositories.
Gynoflor E instructions for use
Gynoflor E (Switzerland) is intended for the treatment of gynecological diseases associated with an imbalance in the microflora and vaginal biocenosis. One tablet of Gynoflor contains 50 mg of acidophilic lactobacilli and 30 mcg of estriol (an inactive secondary female sex hormone, short-acting estrogen). Both components are involved in the physiological mechanism for maintaining normal vaginal biocenosis.
Gynoflor E lactobacilli in the form of a lyophilisate have an antagonistic effect against pathogenic microorganisms, and estriol protects the vaginal epithelium that produces glycogen (a nutrient medium for lactobacilli). Lactobacilli are needed to produce lactic acid, the destructive function of which for microorganisms is to maintain acidity at a pH level of 3.8-4.5. In this environment, all conditionally pathological and pathological microorganisms cease to multiply and increase the zone of their colonies, which leads to the normalization of the vaginal microflora.
Violation of the vaginal microflora can be caused by vaginal infections, systemic diseases, taking antibiotics and hormonal drugs, postmenopause, and poor hygiene. Due to these reasons, the number of lactobacilli is sharply reduced and pathogenic microorganisms settle in their place, causing inflammation of the vaginal epithelium, which becomes thinner and damaged.
The drug Gynoflor additionally contains lactose as a filler, which is fermented by lactobacilli into lactic acid, as a result of which the condition of the vaginal epithelium improves and the normal flora is restored.
The average course of treatment is 6-12 days. Gynoflora tablet is administered intravaginally into the vagina 1 time per day. The procedure is performed on a gynecological chair. Before starting the procedure, the patient must empty the bladder and toilet the external genitalia. The gynecologist inserts a bivalve speculum into the vagina and places the necessary preparation, the speculum is removed, and a tampon is placed in the vestibule of the vagina. It is necessary so that the drug does not leak out. After a few hours, the tablet is resorbed and PH decreases and a proliferative trophic effect on the vaginal epithelium is provided.
Gynoflor indications for use
Restoration of the flora of Lactobacillus acidophilus of the vagina;
Atrophic vaginitis in postmenopause;
Bacterial vaginosis.
Gynoflor contraindications
Suspicion of malignant tumors in the vagina and mammary glands;
endometriosis;
vaginal bleeding;
Virginity;
Hyperplasia of the endometrium;
Simultaneous use with antibiotics;
Hypersensitivity to the drug.
Gynoflor Side Effects
Often a slight itching and burning sensation in the vagina;
Rarely candidiasis (due to acidification of the flora);
Rarely, redness of the vulva and vagina.
Gynoflor how to take
With independent intravaginal administration of the tablet, it is necessary to put on an antiseptic glove before going to bed, take a supine position, slightly bending your knees, inject the drug as deep as possible and close the vestibule with a swab. The course of treatment is 6-12 days. Treatment is carried out under the supervision of a gynecologist. After 2 months, it is necessary to pass an analysis for microflora.
Gynoflor E price
Gynoflor E tab vag, No. 6, Medinowa price: 917 - 1090.88 rubles.
Gynoflor E tab vag, No. 12, Medinowa price: 1373 - 1624.78 rubles.
Store at a temperature of 2-8 degrees. (do not freeze).
Allocations after Gynoflor
Some components of the Gynoflor E tablet may not completely dissolve and end up in the form of secretions on underwear. This does not affect the effectiveness of treatment, but creates discomfort for the patient. Also, the tablet may not completely dissolve if the vagina is dry. In this case, when administered intravaginally, the Gynoflor tablet is moistened in warm boiled water, which will contribute to its rapid dissolution.
In case of discharge during treatment, women should use daily pads. Usually, the discharge begins on the 4th day of intravaginal administration in the late afternoon and is brownish or white with an unpleasant odor. Gradually they pass and after 6 days of treatment they stop.
Gynoflor during menstruation
Before the start of menstruation, treatment with Gynoflor E should be postponed until they are over. If menstruation began during treatment, the administration of tablets should be stopped and resumed only after they have ended.
Treatment with an expensive drug Gynoflor during menstruation does not make sense - it will not harm the body, but there will be no therapeutic effect. Lactobacilli will not take root, but will be washed out with blood from the vagina.
Gynoflor with thrush
Gynoflor with thrush is prescribed after the main treatment with systemic antibiotics as a means to restore the vaginal microflora. As a result of the treatment of thrush with antibiotics, in addition to pathological microorganisms, beneficial lactobacilli also die. When the tablet is inserted into the vagina, estriol enters the vagina, which performs a protective function and 100 million acidophilic viable lactobacilli that secrete lactic acid, which is necessary for the normal state of the epithelium and urethra. Thus, the prevention of thrush (candidiasis) is carried out for the future.
Dosage after the main treatment of candidiasis: 1-2 tablets 1 time per day for 6-12 days.