pharmachologic effect

Blocker of histamine H 1 receptors. It has anti-allergic activity, has a local anesthetic, antispasmodic and moderate ganglioblocking effect. When taken orally, it causes a sedative and hypnotic effect, has a moderate antiemetic effect, and also has a central anticholinergic activity.

When applied externally, it has an anti-allergic effect.

Pharmacokinetics

Rapidly absorbed from the gastrointestinal tract. Bioavailability is 50%. C max is achieved in 20-40 minutes (the highest concentration is determined in the lungs, spleen, kidneys, liver, brain and muscles). Plasma protein binding - 98-99%. Penetrates through the BBB. It is metabolized mainly in the liver, partially in the lungs and kidneys. T 1 / 2 - 4-10 hours. During the day, it is completely excreted by the kidneys in the form of metabolites conjugated with glucuronic acid. Significant amounts are excreted in milk and may cause sedation in infants (a paradoxical reaction characterized by hyperexcitability may occur).

Indications

Allergic reactions (urticaria, hay fever, angioedema), allergic conjunctivitis, vasomotor rhinitis, hemorrhagic vasculitis, serum sickness, pruritic dermatoses, sleep disturbances (monotherapy or in combination with sleeping pills), chorea, sea and air sickness, vomiting of pregnant women, Meniere's syndrome , premedication.

Dosing regimen

Adults inside - 30-50 mg 1-3 times / day. The course of treatment is 10-15 days. As a sleeping pill - 50 mg at bedtime. V / m - in doses of 50-250 mg; IV drip - 20-50 mg.

When taken orally, single doses for children under the age of 1 year - 2-5 mg; from 2 to 5 years - 5-15 mg; from 6 to 12 years - 15-30 mg.

Outwardly apply 1-2 times / day.

Side effect

Maybe: short-term numbness of the oral mucosa, drowsiness, general weakness, a decrease in the speed of the psychomotor reaction; in children, the paradoxical development of insomnia, irritability and euphoria is possible.

Rarely: dizziness, headache, dry mouth, nausea, photosensitivity, accommodation paresis, incoordination, tremor.

Contraindications for use

Angle-closure glaucoma, prostatic hypertrophy, stenosing gastric and duodenal ulcer, bladder neck stenosis, bronchial asthma, epilepsy, hypersensitivity to diphenhydramine.

Use during pregnancy and lactation

During pregnancy and lactation (breastfeeding), diphenhydramine is used with caution, according to strict indications, in cases where the expected therapeutic effect for the mother outweighs the potential risk to the fetus or infant.

drug interaction

With simultaneous use enhances the effect of ethanol and drugs that depress the central nervous system.

With simultaneous use of MAO inhibitors enhance the anticholinergic activity of diphenhydramine.

Antagonistic interaction is noted when co-administered with psychostimulants.

Reduces the effectiveness of apomorphine as an emetic in the treatment of poisoning. Enhances the anticholinergic effects of drugs with anticholinergic activity.

special instructions

Use diphenhydramine with caution during pregnancy and lactation.

During the treatment period, you should not be exposed to sunlight, you should avoid drinking alcohol.

Influence on the ability to drive vehicles and control mechanisms

Use with caution in patients involved in potentially hazardous activities that require increased attention and rapid psychomotor reactions.

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What to do if Diazolin is not at hand?

Diazolin cannot be called a drug of the modern generation. It belongs to the antihistamine group of drugs designed to block the development of allergic reactions of various origins. Diazolin has its analogues, however, it must be understood that a replacement drug is not always able to have the same effect.

First of all, it must be said about what an analogue of a drug is in the medical sense. Usually this is a group of medicines, which are based on the same type of active ingredient. In this case, mebhydrolin, the main active ingredient of the antiallergic drug. But analogues do not mean complete identity, otherwise they would have exactly the same name. They are connected by a common purpose, a common main component, but the similarity ends there. Excipients, which are also part of the drug, can significantly affect the overall result.

It is important to note that Diazolin is more popular and deservedly so:

• minimal sedation;
• minimal risk of side effects;
• affordable price (from 30 rubles per pack).

But it happens that the right Diazolin is simply not at hand. And you need to act immediately if there is a risk of developing an allergy. Therefore, you need to know what analogues exist:

• tavegil;
• suprastin;
• pipolfen;
• dimedrol.

Diazolin analogues: what is the difference

Each person is familiar with at least two substitutes for Diazolin: diphenhydramine and suprastin. Therefore, the comparison must begin with them.

Diphenhydramine, another name for Diphenhydramine, has a wide spectrum of action. Its main purpose is to stop and block allergic reactions, reduce the risk of developing swelling of the mucous membranes. This is a strong remedy and a fairly powerful analogue, but it has two drawbacks that can put it a step below Diazolin. Diphenhydramine cannot be bought without a prescription and has a very pronounced sedative effect. Despite the small size of the tablet itself, the effect of the drug is strong. It excludes the possibility of driving a car and engaging in work that requires special care.

Suprastin, another name Chloropyramine, also has a pronounced hypnotic effect. In addition, the use of Suprastin often causes local allergic reactions when administered intramuscularly. The presence of contraindications for Suprastin is quite impressive, but in general, similar to other Diazolin substitutes.

Tavegil, more often used not only as an anti-allergic drug, but also as a sedative. Unlike such a drug as Suprastin, it is also available in the form of a syrup. It has deep penetration into the central nervous system and is able to depress it for a long time.

Pipolfen- the drug is relatively new, can be used in different areas. Stable sedative effect, high degree of accumulation in the body. A strong drug that can quickly localize the development of anaphylactic shock.

Diazolin and its analogues differ in one factor: they are able to act in the event of bronchial asthma and exert their effect in the event of anaphylactic shock. In this regard, they are more effective than Diazolin itself, which is powerless with the listed consequences of allergies.

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The feasibility of using analogues

Usually, experts advise taking what is at hand. This is especially true in cases where there is every reason to assume the development of stenosis. Normally, patients themselves already know how and which drug acts more fruitfully on them. It should be noted that it is unacceptable to take both Diazolin and its analogues at the same time. If you have already taken one, then you should expect the onset of the effect.

In cases where the drug did not help and the patient began to breathe with difficulty, a team of doctors should be called. It is important to understand that this is not a category of drugs that can be considered safe. Therefore, before use, you must carefully read the contraindications.

Dosage forms

solution for injection 1%, solution for intravenous and intramuscular injection 10mg/ml, solution for injection 10mg/ml

Manufacturers

indeterminate company (Russia), ICN Oktyabr (Russia), ICN Polipharm (Russia), Allergen Stavropol (Russia), Belvitamins (Russia), Belgorodvitamins (Russia), Belmedpreparaty (Belarus), Biomed (Russia), Biosynthesis ( Russia) , Health to the People (Ukraine), Immunopreparat (Russia), Microgen N

Pharmgroup

H1-histamine receptor blockers

International non-proprietary name

Diphenhydramine

Vacation order

Released by prescription

Synonyms

Allergin, Dimedrol-Vial, Dimedrol-UBF, Dimedrol-UVI, Diphenhydramine hydrochloride

Compound

The active substance is diphenhydramine.

pharmachologic effect

Pharmacological action - antihistamine, antiallergic, anticholinergic, antiemetic, sedative, hypnotic, local anesthetic. Blocks histamine H1 receptors and eliminates the effects of histamine mediated through this type of receptor. Reduces or prevents histamine-induced spasms of smooth muscles, increased capillary permeability, tissue swelling, itching and hyperemia. It causes local anesthesia, has an antispasmodic effect, blocks the cholinergic receptors of the autonomic ganglia (lowers blood pressure). It blocks H3-histamine receptors in the brain and inhibits central cholinergic structures. It has a sedative, hypnotic and antiemetic effect. It is more effective in bronchospasm caused by histamine liberators (tubocurarine, morphine, sombrevin) and, to a lesser extent, in allergic bronchospasm. When taken orally, it is rapidly and well absorbed. Most of it is metabolized in the liver, a smaller part is excreted unchanged in the urine. It is well distributed in the body, passes through the BBB. Excreted in milk and may cause sedation in infants. The maximum activity develops after 1 hour, the duration of action is from 4 to 6 hours.

Indications for use

Urticaria, hay fever, vasomotor rhinitis, itchy dermatoses, acute iridocyclitis, allergic conjunctivitis, angioedema, capillarotoxicosis, serum sickness, allergic complications during drug therapy, blood transfusion and blood-substituting fluids; complex therapy of anaphylactic shock, radiation sickness, bronchial asthma, gastric ulcer and hyperacid gastritis; colds, sleep disturbances, premedication, extensive injuries of the skin and soft tissues (burns, crush injuries); parkinsonism, chorea, sea and air sickness, vomiting, incl. during pregnancy, Meniere's syndrome; local anesthesia in patients with a history of allergic reactions to local anesthetic drugs.

Contraindications

Hypersensitivity, breastfeeding, children's age (newborn period and prematurity). Restrictions on use: Angle-closure glaucoma, prostatic hypertrophy, stenosing gastric and duodenal ulcer, pyloroduodenal obstruction, bladder neck stenosis, pregnancy.

Side effect

From the nervous system and sensory organs: general weakness, fatigue, sedation, decreased attention, dizziness, drowsiness, headache, impaired coordination of movements, anxiety, irritability (especially in children), irritability, nervousness, insomnia, euphoria, confusion , tremor, neuritis, convulsions, paresthesia; blurred vision, diplopia, acute labyrinthitis, tinnitus. From the side of the cardiovascular system and blood: hypotension, palpitations, tachycardia, extrasystole; agranulocytosis, thrombocytopenia, hemolytic anemia. From the digestive tract: dry mouth, numbness of the oral mucosa, anorexia, nausea, epigastric distress, vomiting, diarrhea, constipation. From the genitourinary system: frequent and / or difficult urination, urinary retention, early menstruation. From the respiratory system: dryness of the nose and throat, nasal congestion, thickening of bronchial secretions, tightness in the chest and heavy breathing. Allergic reactions: - rash, urticaria, anaphylactic shock. Other: sweating, chills, photosensitivity.

Interaction

Sleeping pills, sedatives, tranquilizers and alcohol increase (mutually) CNS depression. MAO inhibitors enhance and prolong anticholinergic effects.

Overdose

Symptoms: dry mouth, shortness of breath, persistent mydriasis, redness of the face, depression or excitement (more often in children) of the central nervous system, confusion; in children - the development of seizures and death. Treatment: induction of vomiting, gastric lavage, administration of activated charcoal; symptomatic and supportive therapy against the background of careful monitoring of breathing and blood pressure levels.

Method of application and dosage

Intramuscularly - 10-50 mg, the maximum single dose - 50 mg, daily - 150 mg, intravenous drip - 20-50 mg (in 75-100 ml of isotonic sodium chloride solution).

special instructions

Not recommended for subcutaneous administration (irritant). Use with caution in patients with hyperthyroidism, increased intraocular pressure, diseases of the cardiovascular system, in old age. It should not be used during work by drivers of vehicles and people whose profession is associated with increased concentration of attention. During the period of treatment, the use of alcoholic beverages should be avoided.

Storage conditions

List B. In a place protected from light, at room temperature.

Until recently, one of the most common drugs used in various emergency cases in adults and children was Dimedrol. This is a fairly cheap medicine that effectively relieves pain, inflammation, swelling, and an allergic reaction. In addition, Dimedrol has sedative properties. But this drug causes many side effects. Therefore, in recent years it has been practically abandoned. It is believed that it is better to use some analogue of Dimedrol, which is just as effective, but safer. The emergence of new drugs has made it possible to abandon many old drugs. Although in a hospital setting, Dimedrol is still often used to stop allergic attacks.

Instructions for use

The price, analogues and side effects of this medicine are now known mainly to doctors. In recent years, it is almost impossible to buy "Dimedrol" in a pharmacy. Although earlier it was used very widely even for small children. Now this drug is available not only in tablets or injections. You can use rectal suppositories, a suspension for children, or an external allergy remedy - Psilo-balm. Any analogue of Dimedrol, like the drug itself, is contraindicated in such cases:

with peptic ulcer;

bladder pathology;

epilepsy;

prostatic hyperplasia;

during breastfeeding;

children up to 7 months.

Why "Dimedrol" began to be used less frequently

Diphenhydramine, which is the basis of this drug and its analogues, often adversely affects patients. Although this substance is excreted from the body during the day, it manages to cause considerable harm. Therefore, it is very dangerous to take "Dimedrol" on your own, without a doctor's testimony. It is especially not recommended to use it for small children and people who need increased concentration at work.
Any analogue of Dimedrol containing the same active ingredients gives the following side effects:

weakness, drowsiness;

deterioration of psychomotor reactions;

dizziness, euphoria;

excitement, irritability;

convulsions, epileptic seizures, tremor;

impaired coordination of movements;

dry mucous membranes;

lowering blood pressure;

cardiac arrhythmias.

How to buy an analogue of "Dimedrol" without a doctor's prescription

This drug is now very difficult to buy in a pharmacy. Although it costs a penny - about 30 rubles for 10 pieces. Suppositories and children's suspension are a little more expensive, but a doctor's prescription is required to purchase. Indeed, due to the fact that in large doses the drug has a hallucinogenic effect and causes euphoria, it was often used by drug addicts. If you really need to buy an analogue of "Dimedrol" without a doctor's prescription, you can ask for drugs containing the same active ingredient:

"Allergin";

"Dimedrol Bufus";

"Dimedrol Vial";

"Grandim";

"Psilo Balm"

But it is better not to take these medicines on your own. If you really need to treat, for example, an allergic reaction, you can use safer antihistamines that have the same effect as Diphenhydramine: Zirtek, Claritin, Diazolin, Suprastin and others. And as a sleeping pill, it is best to use herbal preparations that contain extracts of motherwort, valerian, mint.

What is the effect of "Dimedrol"

This drug belongs to the first generation antihistamines. When ingested, "Dimedrol" is quickly absorbed into the bloodstream, penetrates the brain and blocks histamine receptors. Due to this, after 15-20 minutes after taking the drug, the following effect is manifested:

spasms of smooth muscles of internal organs are removed;

capillary permeability decreases;

pain passes;

decreased urge to vomit;

allergic reactions are prevented;

passes itching, allergic rhinitis;

the patient calms down, falls asleep easier.

"Dimedrol" acts quickly, so it is now used in hospitals to stop allergic attacks. Moreover, the result of its application lasts 10-12 hours.

When is the use of "Dimedrol" indicated?

A few decades ago, this drug was in every family, and it was often used. Doctors prescribed it even to small children. In a pharmacy, you could buy any analogue of "Dimedrol" in tablets without prescriptions, and it cost a penny. This drug is effective in such cases:

anaphylactic shock;

angioedema;

urticaria, hay fever;

angioedema;

conjunctivitis;

vasomotor rhinitis;

dermatitis with severe itching;

chorea;

seasickness;

insomnia.

This drug is ineffective in allergic bronchospasm. To eliminate such an attack, it is better to use an analogue of "Dimedrol" - "Diazolin". The main active ingredient in it is another component, and the action is very similar: it removes the manifestations of allergies and has a sedative effect.

Means for injection containing "Dimedrol"

Most often now this drug is used in emergency cases. Therefore, it is used in hospitals for injection alone or as part of other drugs. If you need to eliminate Quincke's edema or other serious allergic reactions, Diphenhydramine Hydrochloride, Diphenhydramine Vial, Diphenhydramine Bufus, or simply Diphenhydramine are used.
The best analogue of "Dimedrol" in ampoules is the drug "Grandim". It helps relieve attacks of seasickness, hay fever, recover faster from injuries and burns. After all, it begins to act within 15 minutes after the introduction. In the hospital, mixtures that contain Dimedrol are also often used. They are fast acting and quite effective.

The most common mixture is "Troychatka". It includes "Dimedrol", "Analgin" and "Papaverine". It is used to reduce pressure and temperature, relieve pain after injuries and operations, and in other emergency cases. But recently, more and more often, an analogue of "Dimedrol" - "Loratadin" is included in the composition of this mixture.

Boyko's mixture is also an effective medicine. It is used to relieve severe pain in diseases of the musculoskeletal system. Its main components are "Analgin" and "Dimedrol". They are rarely replaced with analogues, as they are more effective. Other components are added depending on the situation. It can be Papaverine, Novocain, No-Shpa, Prozerin, vitamin B12.

Antihistamines - analogues of "Dimedrol"

Diphenhydramine is one of the earliest antihistamines. It is part of some first-generation allergy medications. In addition to Dimedrol, Allergin and Grandim have a similar composition. These drugs have the same contraindications and side effects as Dimedrol itself. Therefore, in the presence of individual intolerance, it is recommended to choose a drug with a different composition. The best analogue of Dimedrol in tablets is Diazolin. Their action is almost identical. "Diazolin" also relieves the manifestations of an allergic reaction, facilitates breathing and eliminates itching. In addition, it has a mild hypnotic effect. Therefore, for those who are used to escaping from malaise with the help of Dimedrol, you can buy Diazolin. But it is best, and especially for children, to use second and third generation antihistamines. They are more effective and have almost no side effects. These are Clarotadin, Lorahexal, Telfast, Zirtek, Fenistil and others. But often such drugs do not have a sedative effect.

Calming drugs - analogues of "Dimedrol"

Now people often suffer from insomnia and other sleep disorders. Many representatives of the older generation are used to taking Dimedrol in this case. They liked that it was inexpensive and had a quick effect. In addition, along with the fact that "Dimedrol" helps to fall asleep, it relieves itching and pain. But now this drug has become almost impossible to buy. Therefore, many are interested in pharmacists, the drug has the same effect as Dimedrol. Doctors usually prescribe medications depending on the cause of insomnia:

with bronchial asthma, Zopiclone or Somnol soothes well;

"Sondox" improves the quality of sleep, soothes, relieves itching;

Donormil is often considered a substitute for Dimedrol to normalize sleep, since it is also a blocker of histamine receptors.

But it is best to use herbal preparations. They have a mild sedative effect and are not addictive. But among them there are those that contain strong chemicals. The most popular drug with this composition is Valemidin. Plant-based analogues without Dimedrol are Novo-Passit, Persen and others.

Everyone knows that with insomnia and anxiety, Diphenhydramine is used for sleep. In addition, this drug has antihistamine, analgesic and antispasmodic effects. In order for the drug to have the desired effect on the human body, you need to know its indications, as well as possible side effects.

Description of the drug

Diphenhydramine is produced in the form of tablets in blisters of 20, 30 or 50 mg, ampoules for intramuscular or intravenous injections. In addition, the following dosage forms are on sale:

• soluble powder;
• liquid capsules;
• candles;
• stripes;
• gels.

The active ingredient is diphenhydramine.

What are the indications for use

The drug in various forms of release is prescribed for the treatment of such pathologies:

• insomnia;
• allergic conjunctivitis, rhinitis;
• the reaction of the body to the flowering of plants;
• serum sickness;
• acute iridocyclitis;
• hives;
• itchy dermatoses;
• hay fever;
• complications of an allergic nature in the treatment of radiation sickness, blood transfusions and replacement fluids;
• angioedema;
• treatment of abnormal movements, including Parkinson's disease, Meniere's syndrome;
• in the complex therapy of gastric ulcer, anaphylactic shock, bronchial asthma, gastritis;
• injuries of the skin, soft tissues;
• motion sickness and vomiting in transport, with air and sea sickness.

The dosage and treatment regimen is prescribed by the doctor after the examination and examination of the patient.

Opinion of a somnologist: “Diphenhydramine (Diphenhydramine) is a drug from the group of H1 blockers - first-generation histamine receptors, created in the 40s in the USA and at that time was the first drug for the treatment of allergies.
In addition to the decongestant, analgesic, antiemetic effect, it has a pronounced sedative effect.

It depresses the central nervous system, causes dizziness, impaired coordination, decreased concentration (which is especially bad for working active patients). The effect of the drug depends on the dose and duration of administration, over time, an increase in dosage is required, which leads to the manifestation of side effects (for example, dry mucous membranes, blurred vision, gastrointestinal dysfunction).

Nowadays, Diphenhydramine is widely used in emergency situations, in a hospital or in combination with drugs for the treatment of seriously ill patients.
The use of Dimedrol at home alone to correct insomnia is not justified and dangerous. Now there are other safer drugs for the treatment of insomnia.”

Somnologist.

Contraindications and special instructions

Along with a large area of ​​​​use, Diphenhydramine has a number of contraindications that should not be neglected.

It is forbidden to take this drug to persons who have shown hypersensitivity to the components of the drug, while driving a vehicle, as well as in the presence of the following diseases:

• prostatic hypertrophy;
• closed glaucoma;
• epilepsy;
• stenosis of the stomach ulcer, neck of the bladder;
• children (prematurity and neonatal period).

It is necessary to carry out therapy with Diphenhydramine drugs with caution in cases of pulmonary pathologies, increased intraocular pressure, in old age, with diseases of the heart and blood vessels, pulmonary pathologies, during pregnancy and lactation. The substance is not recommended for use by people who, by the nature of their activities, require concentration of attention or control of transport.

People with PKU need to be aware that instant capsules and chewable tablets containing Diphenhydramine often contain aspartame, a source of phenylalanine.

Side effect

Uncontrolled use of the drug, its overdose or combination with other pharmaceutical products can provoke the development of adverse reactions.

The most commonly observed disorders are:

• on the part of the digestive system: dry mouth, nausea, vomiting, impaired stool, loss of appetite, mucosal numbness;
• nervous system: drowsiness, neuritis, convulsions, fatigue, euphoria, impaired coordination of movements, weakness, headache;
• violation of the respiratory system: congestion or dryness of the nasal passages, difficulty breathing, thickening of bronchial secretions;
• changes in the activity of the heart and the state of the vessels, namely: palpitations, thrombocytopenia, hypotension, anemia, tachycardia;
• allergic reactions.

In addition, the patient may experience increased sweating or chills, photosensitivity.

In case of an overdose, a pronounced depression or overexcitation, depression, dilated pupils, redness of the face.

If an injection is necessary, doctors do not recommend the method of administering an injection under the skin.

Attention! In severe cases, children may develop confusion, convulsions, and even death.

After taking the drug to relieve side effects, it is necessary to do a gastric lavage, control blood pressure.

Benefits of using

Reviews of people who took Diphenhydramine in various forms indicate that it can be very effective in the development of infectious diseases, relieving swelling and redness in the mucous membranes and helping the patient fall asleep.

Diphenhydramine in combination with other drugs well brings down the high temperature, enhances the effect of the latter. This lytic mixture has an analgesic and hypnotic effect. With the manifestation of allergic reactions on the skin, it is better to use ointments, aerosols or lotions that contain diphenhydramine. Such drugs have a local effect on the problem area, relieve itching and discomfort. In addition, topical application avoids systemic effects such as drowsiness and does not affect the gastric mucosa. For insect bites, you can use the solution from the ampoule, which you need to moisten a cotton swab and apply to the affected area.

Other pluses:

• cheapness;
• fast action;
• pressure reduction;
• calming effect;
• preservation of the effect during the day.

Negative points

Despite a number of positive qualities, the tool has drawbacks that make you think about the appropriateness of its use.

Minuses:

• prescription only;
• new generation analogues are more accessible and cause fewer adverse reactions;
• in the form of injections is more effective than in tablets;
• addictive;
• toxic, may cause hallucinations;
• must be taken strictly according to the instructions;
• lethargy, inability to control emotions;
• causes headache and feeling unwell the next morning.

Is it possible to give to children

It is not recommended to take pills for the treatment of colds and coughs. The child may choke. In the case of removing allergic manifestations, it is better to use rectal suppositories, after making an enema. For insomnia or sleep disturbance, children are given milder sedatives that do not cause complications. Intramuscularly, Diphenhydramine is administered to children only in mixtures with other pharmaceutical products in order to reduce high fever under the supervision of a physician.

During pregnancy and lactation

Use this drug during pregnancy can only be prescribed by a specialist. If the pathology can have serious consequences and adversely affect the fetus, a woman may be allowed to take this substance, taking into account the duration of pregnancy. In this case, the treatment of symptoms of urticaria, conjunctivitis or pruritic dermatosis is carried out by a single or double dose of tablets.

Important! In the first and second trimester Diphenhydramine is contraindicated.

During lactation, the drug is not prescribed due to the development of the risk of complications for the child.

How it affects the elderly

People over 65 years of age should not take the drug due to the fact that they can haveanticholinergic effect, which has such manifestations:

• disturbance of accommodation;
• increased heart rate;
• dizziness;
• urinary retention
• constipation, intestinal obstruction;
• memory loss.

Interaction with alcohol

Preparations containing dimerdol enhance the effect of alcohol and cause irreparable harm to the body. First of all, the liver and kidneys suffer. Taking a small dose of alcohol with a tablet of the drug, an alcoholic falls into drug intoxication. Outwardly, this is manifested in increased gesticulation, excitement and aggression. Then comes a sound sleep without dreams. Often there are terrible hallucinations, they are accompanied by hand tremors, blurred vision, tachycardia. The repeated combination of Diphenhydramine with alcoholic beverages leads to apathy, dependence, destruction of the personality and death.