Norkolut instructions for use. Norkolut: instructions for use of tablets. Absence of menstruation after treatment

Menstrual irregularities are a common problem among women. This is often associated with diseases of the reproductive system, stress, hormonal disruptions. To eliminate it, the specialist prescribes medications that normalize the menstrual cycle. Norkolut can be prescribed, and menstruation after a course of therapy begins on time. The drug helps not only to restore the cycle, but also, if necessary. It is taken according to the scheme, strictly according to the doctor's prescription.

About the drug

Norkolut tablets are most often prescribed for cases that are not caused by pregnancy. The drug is taken according to the scheme prescribed by the gynecologist. The main active ingredient of the drug is norethisterone, which is a progestogen. An insufficient amount of this substance in the female body causes a delay in menstruation, infertility.

Once in the body, the drug acts, replenishing the amount of progestogen. Due to this, after a course of therapy, menstruation occurs at the right time. Norkolut can be prescribed for the treatment of endometriosis, uterine adenoma, mastopathy. It helps alleviate the symptoms of menopause.

It must be remembered that Norkolut enters into drug interactions with other drugs taken during this period. It can weaken their action. The gynecologist must be informed if there is a need for daily intake of other drugs. If possible, they should be abandoned for the duration of treatment with Norkolut.

In individual cases, the appointment of the drug is impossible. Then the doctor chooses among the analogues of Norkolut, suitable for a woman.

It is strictly forbidden to independently change the prescribed drug, dosage. Taking Norkolut according to the scheme prescribed by the gynecologist will help normalize the menstrual cycle, eliminate a number of diseases of the reproductive system.

Indications and contraindications

Experts have identified a number of indications for taking the drug:

1. Norkolut for calling menstruation is prescribed for their delay, complete absence.
2. The use of the drug helps to remove severe pain during menstruation.
3. The active components of the drug neutralize the pronounced premenstrual syndrome.
4. Treatment of endometriosis, uterine fibroids, mastopathy.
5. Relief of the condition of a woman in. Norkolut helps to soften the unpleasant, painful.
6. The remedy can be prescribed to a woman during lactation, if there is a decrease, cessation of milk production.

When prescribing a remedy, the condition of the woman, the individual characteristics of the body are taken into account. There are a number of contraindications for which it is necessary to select an analogue.

1. An absolute contraindication to admission is the presence of malignant neoplasms in the mammary glands, organs of the reproductive system.
2. The tool should not be taken by children, adolescents.
3. An allergic reaction to the active components of the product completely excludes its use.
4. Pregnancy is a contraindication. Norkolut can cause miscarriage.
5. In the presence of pathological processes in the liver, the drug is contraindicated.
6. Diseases of a neurological nature.
7. Bronchial asthma.
8. Unstable blood pressure - sharp drops in indicators from high to low.
9. Diseases of the urinary tract, kidneys.

Norkolut may be contraindicated in case of taking other drugs containing the same active ingredients. Therefore, the doctor should be informed about taking other medications. Ignoring this recommendation can lead to a deterioration in the general condition. During treatment, it is forbidden to drink alcohol. The gynecologist must be informed of all chronic diseases in order to avoid negative consequences.

Norkolut can provoke side effects. They all manifest individually, may be completely absent. During therapy, you need to monitor your condition, if necessary, the remedy is canceled, an analogue is selected. May occur:

• violation of the digestive tract - nausea, vomiting, heaviness;
• headache;
• fast fatiguability;
• skin rashes, redness, itching;
• feeling of heaviness in the mammary glands;
• puffiness;
• increased blood clotting;
• increased levels of bilirubin in the blood;
• weight gain;
• bleeding. It can be spotting or heavy discharge.

In case of side effects, especially bleeding, you should consult a doctor. He will cancel or adjust the treatment regimen until the woman's condition stabilizes. Self-medication can be dangerous to health and life.

Release form

Norkolut has a single release form - white, round tablets. 1 tablet contains 5 mg of noriethisterone, which acts as an active ingredient. There are also a number of auxiliary components. It:

1. lactose monohydrate.
2. Potato starch.
3. Corn starch.
4. Talc.
5. Gelatin.
6. Silicon dioxide colloidal.
7. Magnesium stearate.

In a paper package 2 blisters of 10 tablets, located in contour cells.

How to take to delay menstruation

In some cases, the period of arrival of menstruation must be postponed. In this case, Norkolut helps to delay menstruation. A gynecologist will write a detailed scheme; it is not recommended to select dosages on your own. Noriethisterone, acting on the body, does not allow the germ cell to exit in a timely manner. As a result, the thick period of the endometrium is not rejected, menstruation does not begin.

It is necessary to start drinking the drug 7 days before. When following the doctor's recommendations, taking the pills correctly, the date of their start is postponed by 7-10 days. Norkolut to delay menstruation is stopped under the supervision of a gynecologist. It is strictly forbidden to stop the course of admission on your own. This can worsen the general condition, provoke bleeding.

How to take with a delay

To induce menstruation, Norkolut is prescribed. The dosage and scheme is developed by the doctor, taking into account the individual characteristics of the patient's body. Detailed instructions for use are in each package, but this does not mean that treatment can be started independently. The wrong dosage can harm a woman.

Norkolut with a delay in menstruation is prescribed in the amount of 2 tablets per day. Treatment is prescribed only by a gynecologist. You need to take them in the morning and in the evening. This is the standard treatment regimen. Duration of admission - 7 days with a delay in menstruation. After that, a break is made for 8 days, menstruation begins. In some cases, it starts a few days earlier, it all depends on the woman's body, the problem that provoked the delay.

Another treatment regimen may be prescribed, providing for taking the 1st tablet of the drug for 10 days. In the case when menstruation has not occurred after cancellation within 8 days, it is necessary to visit a gynecologist. Increase the dosage, the duration of the reception is strictly prohibited.

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When will menstruation start after taking

After taking Norkolut, menstruation will begin in about 8 days. This is the maximum amount of time. If the delay continues, you should consult a doctor. The individual characteristics of the body, the presence of other chronic diseases can directly affect the time of the onset of menstruation. In some cases, rejection of the endometrium, its exit begins even while taking the drug. In this case, it can be canceled immediately.

Appearing testify to the imminent onset of menstruation. Menstruation can begin immediately the next day after taking the last pill, but even when they occur after 8 days, this is considered the norm.

Absence of menstruation

In some cases, there is a situation when there is no menstruation after Norkolut. In the first case, it can be caused by pregnancy. A home pregnancy test and an examination by a gynecologist will help to refute or confirm the hypothesis. In case of pregnancy, taking the drug is contraindicated, this must be taken into account, do not start taking it yourself without prior consultation.

Menstruation does not come, as a result of the slow development of the endometrium of the uterus. Norkolut is a means that inhibits its development in itself and this becomes the reason that its rejection does not come in a timely manner, the way out. The drug affects the level of hormones, the level of progesterone decreases. If there is also an insufficient amount of estrogen in the woman's body, menstruation cannot begin on time, even when exposed to Norkolut.

It is forbidden to self-medicate by changing the dosage. You should contact a gynecologist. He will tell you what to do, correct the treatment regimen.

How do menses behave?

The hormonal drug Norkolut has a strong effect on the endometrium of the uterus. In this regard, the interest of a woman is natural, what will be the menstrual cycle in the future. His character can change not only under the influence of pills, but also for the reason that caused the delay,. The gynecologist tells what can be considered the norm, the natural reaction of the body.

During the reception

When taking Norkolut, the onset of menstruation is possible. The process is natural, as the body reacts to the active ingredients of the product. At the beginning and end of menstruation, spotting is observed. During this period, the doctor may stop taking the medicine. Character, it ends quickly, but this is considered the norm and should not cause concern. An individual reaction may be nausea, vomiting during this period, increased pain. There may be swelling of the extremities. Further .

After taking

Studying menstruation after Norkolut, doctors found that their nature may not change. In individual cases, temporary changes in their course are observed. Abundant periods do not always occur, but they can be breakthrough in nature, resembling bleeding. The woman needs qualified help. Gynecologists call a side effect provoked by the medication. Bleeding can occur against the background of endometriosis, endometrial hyperplasia.

In most cases, the discharge is scarce. This is due to the increased blood clotting caused by the drug and a slight overgrowth of the endometrium. The blood coming out is darker in color. There may be a shortening of the period of menstruation after taking the drug. This state persists for several cycles in a row, gradually everything will return to the previous schedule.

Compound

Active substance: norethisterone; 17α-ethynyl-17β-oxy-4-estren-3-one

1 tablet contains 5 mg norethisterone;

Excipients: potato starch, magnesium stearate, colloidal silicon dioxide, gelatin, talc, corn starch, lactose.

Dosage form

Tablets.

Pharmacological group

Hormones of the gonads and drugs used in the pathology of the genital area. Gestagens. ATC code G03D C02.

Indications

Secondary amenorrhea, endometriosis.

Contraindications

Norcolut® should not be used in the presence of any of the conditions or diseases listed below.

• Pregnancy or suspicion of it.
• Breastfeeding.
• Formation of a blood clot in a vein (thrombosis), such as in the blood vessels of the legs (deep vein thrombosis) or lungs (pulmonary embolism).
• High risk of venous or arterial thrombosis.
• Conditions preceding thrombosis (including transient ischemic attack, angina pectoris) in history.
• Migraine with a history of focal neurological symptoms.
• Diseases associated with impaired circulation in the arteries, such as myocardial infarction or stroke, now or in the past.
• Diabetes mellitus with vascular complications.
• Severe liver disease, present or in the past, as long as liver function tests are not normal. Symptoms of liver diseases can be, for example, yellowing of the skin and / or itching of the whole body.
• Dubin-Johnson syndrome, Rotor syndrome, as well as jaundice or cases of severe pruritus during previous pregnancies.
• Previous cases of gestational pemphigoid (pregnancy herpes).
• Benign or malignant tumors of the liver at present or in the past.
• Malignant tumors that are dependent on the influence of sex hormones (for example, the breast or genital organs), which are present or have been in the past.
• Hypersensitivity to norethisterone or to any of the auxiliary components of the drug.

If any of the above conditions occurs for the first time while taking the drug, you should immediately stop taking it and consult your doctor.

Dosage and administration

Tablets should be taken whole with liquid, without chewing.

The effectiveness of Norcolut® tablets may be reduced if the patient forgets to take the tablet as directed. The patient should only take the last missed tablet as soon as she remembers and then continue taking the tablets at the usual time the next day.

If contraceptives are needed, then non-hormonal methods of contraception should be used additionally.

Secondary amenorrhea

Any hormonal therapy for secondary amenorrhea can only be given after pregnancy has been ruled out. In some cases, secondary amenorrhea is due to prolactinoma, which should be excluded before starting the use of Norkolut®.

The doctor prescribes a drug containing estrogen (for example, for 14 days) before Norcolut® is started. After that, take 1 tablet Norkolut® 1-2 times a day for 10 days. Withdrawal bleeding starts a few days after taking the last pill.

When a sufficient level of estrogen production is achieved, one can try to stop estrogen therapy and induce cyclic bleeding with 1 tablet of Norcolut® 2 times a day from the 16th to the 25th day of the cycle.

endometriosis

Treatment should be started between the first and fifth day of the cycle using 1 tablet of Norkolut® twice a day. In case of spotting, it is necessary to increase the dose and take 2 tablets of Norcolut® twice a day. After the bleeding stops, you can reduce the dose to the initial one. The duration of the course of treatment is at least 4-6 months. With continuous daily use of the drug, ovulation and menstruation are absent. Withdrawal bleeding occurs after hormone therapy is completed.

Adverse reactions

Side effects are more common in the first months after the start of taking Norkolut®.

Such adverse events have been reported in patients treated with noritesterone, although a causal relationship could not always be confirmed. The following are adverse reactions by MedDRA organ system classes.

From the immune system: hypersensitivity reactions.

From the nervous system: headache, migraine.

On the part of the organ of vision: blurred vision.

On the part of the respiratory system, chest and mediastinum: shortness of breath.

From the digestive system: nausea.

From the skin and subcutaneous tissue: urticaria, rash.

On the part of the reproductive system and mammary glands: uterine / vaginal spotting, including spotting * non-intense menstruation (hypomenorrhea) *, amenorrhea *.

General violations in the application: edema.

* When used according to the indications of "Endometriosis".

The following adverse reactions are described in more detail in the "Peculiarities of use" section:

• thromboembolism,
• liver tumors that lead to intra-abdominal bleeding,
• chloasma,
• severe headache and migraine or increased frequency of unusually severe migraine sudden disturbances in perception; the first signs of thrombophlebitis or symptoms of thromboembolism, a feeling of pain and compression in the chest, the appearance of jaundice, the development of hepatitis, itching of the skin, a significant increase in blood pressure.

Very high doses of Norkolut® can in some cases lead to cholestatic liver disorders.

Overdose

Acute toxicity studies have not shown a risk of acute adverse reactions in case of accidental administration of the drug at a dose several times higher than the daily therapeutic dose.

Use during pregnancy or lactation

Norkolut® should not be used by women during pregnancy or if it is suspected and during breastfeeding.

Children

The drug should not be used in children.

Application features

With prolonged use of the drug, increased caution should be exercised in the following cases: diseases of the cardiovascular system and kidneys, bronchial asthma, epilepsy, a tendency to thrombosis, hepatitis, impaired liver function.

Before starting the use of Norkolut®, it is necessary to conduct a thorough gynecological, oncological examination and examination of the mammary glands.

Patients with a history of depression should also be under close medical supervision. It is necessary to stop taking the drug if depression progresses. Medical examination, including gynecological examination, should be repeated periodically during treatment with the drug. The frequency and type of these studies depend on the individual characteristics of each woman, but without fail they should include pressure measurement, examination of the mammary glands, abdominal and pelvic organs, as well as cytological examination of the cervix.

You should contact your doctor as soon as possible if you experience:

• any changes in the state of health, especially those indicated in this instruction;
• local compaction in the mammary gland;
• the need to use other drugs (see also the section "Interaction with other drugs and other types of interactions");
• prolonged immobility or the need for elective surgery (should consult a doctor at least 6 weeks before it)
• the occurrence of unusual, profuse vaginal bleeding.

You should stop using the tablets and immediately consult a doctor if there are possible signs of thrombosis:

• unusual cough;
• pain or tightness in the chest, radiating to the left arm;
• dyspnea
• frequent unusually severe or prolonged headache or first migraine attack;
• partial or complete loss of vision or double vision;
• slurred speech;
• sudden changes in hearing, smell, or taste;
• dizziness or loss of consciousness;
• weakness or loss of sensation in any part of the body
• severe leg pain or swelling.

You should also stop using the tablets and consult a doctor immediately if you experience:

• jaundice (yellowing of the skin, whites of the eyes, may be a sign of hepatitis)
• generalized severe itching;
• high blood pressure
• pregnancy.

These situations and symptoms are described and explained in more detail in other sections of the Instructions.

Precautionary measures.

In the event of the presence or exacerbation of any of the following conditions when using the drug, you should consult a doctor. The doctor will determine the benefit and risk of starting or continuing the use of the drug and determine whether there is a need for close monitoring by the doctor:

• smoking;
• diabetes
• overweight;
• thrombosis / embolism in the past;
• thrombosis in one of the closest relatives (venous thromboembolism in brothers or sisters or parents at a relatively young age);
• breast cancer in any of the immediate family;
• chloasma (yellowish-brown patches of pigmentation on the skin, especially on the face) at present or in the past. If they are, it is necessary to avoid prolonged exposure to the sun or ultraviolet radiation;
• depression in the past.

If any of the above conditions develop for the first time, recur or worsen with the use of the drug, you should consult a doctor.

Thrombosis

Based on the results of epidemiological studies, it was concluded that the use of oral estrogen / progestogen preparations, which are used for contraception, is accompanied by an increase in the incidence of venous thrombosis compared with women who do not use drugs of this type.

The risk of venous thromboembolism (VTE) is highest during the first year of use. This increased risk is observed after the first or repeated (after 4 weeks or more of a break in taking) the same or a different COC is started. The increased risk is observed mainly during the first 3 months.

VTE can be life threatening or fatal.

Venous thromboembolism (VTE), manifested by deep vein thrombosis and/or pulmonary embolism, can occur with any COC.

Very rarely, thrombosis of other blood vessels, such as arteries and veins of the liver, kidneys, mesenteric vessels, veins and arteries of the brain or retina, has been reported in women using COCs. To date, there is no consensus regarding the relationship of these complications with the use of COCs.

Symptoms of deep vein thrombosis (DVT) may include: unilateral diffuse swelling of the lower extremity or swelling along the vein pain or tenderness in the leg that may only be felt when standing or walking, increased warmth in the affected leg, redness or discoloration of the skin of the leg.

Symptoms of pulmonary embolism (PE) may include: sudden unexplained shortness of breath or rapid breathing; sudden cough (hemoptysis) sharp pain in the chest, which may be aggravated by deep breathing; feeling anxious, severe dizziness or vertigo; fast or irregular heartbeat. Some of these symptoms (eg, shortness of breath, cough) are nonspecific and may be misinterpreted as more common or less severe conditions (eg, respiratory tract infections).

Arterial thromboembolic events may include cerebrovascular accident, vessel occlusion, or myocardial infarction (MI). Symptoms of a cerebrovascular accident may include: sudden numbness or weakness of the muscles of the face, arms or legs, especially on one side of the body sudden confusion, slurred speech, sudden blurred vision in one or both eyes, sudden difficulty walking, dizziness, loss of balance or incoordination; sudden, severe, or prolonged headache with no apparent cause; loss of consciousness or fainting with or without an epileptic seizure. Other signs of vessel occlusion may include: sudden pain, swelling, slight bluing of the limb; "Acute" belly.

Symptoms of MI can be: pain, discomfort, pressure, feeling of heaviness, squeezing or fullness in the chest, arm or chest; pain that may radiate to the back, jaw, throat, arms, abdomen, feeling of fullness, indigestion; sweating, nausea, vomiting or dizziness, severe weakness, restlessness, shortness of breath, rapid or irregular heartbeat.

Arterial thromboembolic events can be life-threatening or fatal.

Factors that increase the risk of venous or arterial thrombotic / thromboembolic events or cerebrovascular events:

• age;
• obesity (body mass index over 30 kg/m2);
• positive family history of thrombosis (for example, cases of venous or arterial thromboembolism in siblings or parents at a relatively early age). If there is evidence or suspicion of a hereditary predisposition, the woman should be referred for a consultation with an appropriate specialist before deciding on the use of any PDA;
• prolonged immobilization, extensive surgical interventions, any surgical operations on the lower extremities, significant injuries. In these cases, it is recommended to stop using the PDA (for elective operations - at least 4 weeks before it) and start taking the drug again no earlier than 2 weeks after complete remobilization;
• smoking (in combination with heavy smoking and increasing age, the risk increases, especially in women over 35 years old);
• dyslipoproteinemia;
• arterial hypertension;
• migraine
• heart valve disease;
• atrial fibrillation
• postpartum period.

There is no consensus on the possible role of varicose veins and superficial thrombophlebitis in the occurrence of venous thromboembolism.

Other conditions that may be associated with adverse circulatory events include diabetes mellitus, systemic lupus erythematosus, hemolytic uremic syndrome, chronic inflammatory bowel disease (Crohn's disease or ulcerative colitis), and sickle cell anemia.

An increase in the frequency or intensity of migraine during COC use (which may be a precursor to cerebrovascular events) may require urgent discontinuation of COC use.

Biochemical parameters that can be used to determine hereditary or acquired predisposition to venous or arterial thrombosis include: resistance to activated protein C (APC), hyperhomocysteinemia, antithrombin III deficiency, protein C deficiency, protein S deficiency, the presence of antiphospholipid antibodies (anticardiolipin antibodies lupus anticoagulant).

Tumors

The most important risk factor for developing cervical cancer is the persistence of human papillomavirus (HPV) infection. Some epidemiological studies have shown that long-term COC use may increase this risk. However, this statement is still controversial, as it is not completely clear whether the results of the studies took into account concomitant factors, such as the regularity of cervical screening and sexual behavior, including the use of barrier methods of contraception.

There is a slight increase in the risk of developing breast cancer in women using COCs. This increased risk gradually disappears within 10 years after the cessation of COC use. Because breast cancer is rare in women under 40 years of age, the increase in breast cancer in women who currently use or have recently used COCs is small compared to the overall risk of breast cancer. The results of these studies do not provide evidence for a causal relationship. An increased risk has been identified that may be due to both the earlier diagnosis of breast cancer in women using COCs, and the biological effect of COCs, or a combination of both factors. It is noted that breast cancer detected in women who have ever taken COCs, as a rule, is clinically less pronounced than in those who have never used COCs.

Malignant tumors can be life-threatening or fatal. You should immediately consult a doctor if you experience severe abdominal pain for the first time.

Other diseases

Although a slight increase in blood pressure has been reported in many women taking COCs, clinically significant increases are rarely observed. However, if persistent clinically significant hypertension develops while taking a COC, the doctor should stop the COC and begin treatment of arterial hypertension. If normal blood pressure levels are achieved after antihypertensive therapy, COC use may be reintroduced if deemed appropriate.

The occurrence or exacerbation of the following diseases during pregnancy and with the use of COCs has been reported, but their relationship with the use of COCs has not been conclusively proven:

• jaundice and/or itching associated with cholestasis;
• the formation of gallstones;
• porphyria;
• systemic lupus erythematosus,
• hemolytic uremic syndrome
• chorea;
• herpes pregnant
• hearing loss associated with otosclerosis.

In women with hereditary angioedema, exogenous estrogens may cause or exacerbate the symptoms of the disease.

Women quite often face a situation where there is a delay in menstruation. This problem occurs for various reasons: pregnancy, stress, climate change, bad habits, heavy workloads, taking certain medications or gynecological diseases. In many cases, gynecologists prescribe Norkolut to induce menstruation. The active component in its composition is an analogue of hormones such as gestagens, the lack of which leads to a delay.

Norkolut will help induce menstruation

The active ingredient of the drug is norethisterone. Such a substance is a hormone of synthetic origin, which has similar properties with gestagens. The process of calling the onset of menstruation when prescribing Norkolut (and its correct intake) is based on a complex effect on the body:

• the tool helps to maintain the uterus in a phase called premenstrual;
• the development of a new egg slows down, and ovulation does not occur;
• the uterine muscles relax and their tone decreases;
• the medication normalizes the balance of hormones, which is why most often there are delays in critical days.

After the start of the use of Norkolut hormonal tablets, monthly bleeding appears after a few days (from three to seven). In addition, their regularity is restored.

If menstruation does not come after using Norkolut, then the gynecologist adjusts the dosage or even prescribes another medication.

What are the indications for the use of the drug

The main indication for the use of the drug is the induction of menstruation. However, doctors prescribe Norkolut in other situations:

• mastodynia, mastopathy - diseases manifested by soreness in the area of ​​\u200b\u200bthe mammary glands;

The drug is prescribed for diseases of the uterus

• painful periods;
• pronounced PMS - premenstrual syndrome;
• identified pathology of a benign nature - endometriosis;
• reduction of symptoms in menopause;
• mucosal proliferation - endometrial hyperplasia.

Often, the drug is prescribed if necessary to complete the lactation period. There are also cases when women take Norkolut for a different purpose - to delay menstruation.

What are the contraindications for use

Not every woman is allowed to use this medication. There are also contraindications to its use. Therefore, self-administration of Norkolut is not recommended. It should only be used as directed by an experienced gynecologist. The drug is contraindicated in the following conditions:

• age less than 18 years;
• intolerance to the components that make up the product;
• pregnancy planning and gestation;

The herpes virus is one of the contraindications to the use of this drug.

• breast cancer;
• increased amount of bilirubin;
• oncological diseases of the genital organs;
• herpes;
• liver pathology;
• the presence of blood impurities in the urine;
• obesity;
• inflammation or blockage of the veins.

The drug should not be taken together with phenytoin, cimetidine and rifampicin.

The remedy is not recommended (but sometimes prescribed under the close supervision of a doctor) for women with heart failure, hypertension, diabetes, various kidney diseases or epilepsy.

How to take Norkolut to delay menstruation

Sometimes situations arise in which a woman needs to delay her monthly bleeding for several days. The reason for this may be an important event, a trip to the sea, vacation. In this case, Norkolut is prescribed. His reception should begin a week, or rather, eight days before the expected day of the onset of menstruation. The dosage, as well as the duration of use, is determined only by the gynecologist (for each woman individually).

The drug is taken as prescribed by the doctor

This regimen allows you to delay menstruation for a maximum of ten days. Before the course, you should consult with your doctor about the method of drug withdrawal.

How to use the medicine to induce menstruation

The drug is used in gynecology as an alternative to progesterone injections. It is recommended to start taking Norkolut, which is prescribed to cause menstruation, from the sixteenth day of the cycle. There are three regimens for taking the medication. They are included in the table below.

It is advisable to take the remedy every day at the same time. Women usually prefer to take pills in the morning.

What are the periods after Norkolut

Menstruation after using Norkolut usually remains the same as it was before. Some women note that after a long absence of critical days, the discharge is rather scarce. Their intensity may not change throughout the menstruation. However, the duration of menstruation often becomes shorter.

Abdominal pain during menstruation

With bleeding, unpleasant symptoms often appear: nausea, severe pain in the lower abdomen, swelling of the extremities. The drug causes heavy bleeding only in very rare cases. If they are excessively strong, breakthrough, then you should immediately seek the help of doctors.

In gynecological practice, there are cases when, after taking Norkolut, there are no periods, they are delayed. This is not typical for this drug, but it can happen due to the characteristics of the body of each woman. It should be understood that the resolution of a situation in which there is no menstruation after the abolition of Norkolut is possible only together with a gynecologist.

How long does the cycle recover after treatment

After the abolition of Norkolut, menstruation begins in a couple of days. Restoration of the cycle and duration of menstruation can occur up to several months. However, if you strictly follow the rules for taking the drug, then the condition returns to normal immediately from the very first critical day.

You can learn about the drugs that cause menstruation from this video:

Every woman's body is different. Therefore, the effects of the use of the drug may vary. Most of the fair sex note the positive effect of Norkolut, thanks to which their cycle has been adjusted.

However, gynecologists have also encountered opposite situations, when women after Norkolut do not have menstruation or hormonal disruptions occur, the general condition worsens while taking the drug.

What are the possible side effects

Any drug causes certain side effects. Norkolut is no exception. It can cause such negative manifestations as:

• pain in the abdomen, flatulence, nausea and even vomiting;
• allergic reaction;
• migraine, headaches;
• varicose veins, vein thrombosis;
• weight gain;
• severe fatigue.

Taking the drug can cause varicose veins

If adverse reactions occur, you must immediately stop taking the medication and consult a gynecologist.

Excipients: potato starch, magnesium stearate, colloidal silicon dioxide, gelatin, talc, corn starch, lactose monohydrate.

10 pieces. - blisters (2) - packs of cardboard.

pharmachologic effect

Norethisterone is a progestogen. It causes the transformation of the uterine mucosa from the proliferation phase to the secretory one, blocks the secretion of gonadotropin in the pituitary gland, preventing the maturation of follicles and the onset of ovulation.

Pharmacokinetics

Suction

Well absorbed from the gastrointestinal tract. As a result of intensive primary metabolism in the liver and in the intestinal wall, bioavailability is 50-77%.

Distribution

0.5-4 hours after taking 0.5 mg norethisterone Cmax in serum is 2-5 ng / ml, when taking 1 mg - 5-10 ng / ml, when taking 3 mg - 30 ng / ml.

Metabolism

Metabolites of norethisterone are excreted by the kidneys in the form of conjugates with glucuronic acid.

breeding

Excretion of conjugated metabolites - through the intestines (40%) and kidneys (60%).

The decrease in the concentration of norethisterone in serum is carried out in two phases. T 1 / 2 in the first phase lasts 2.5 hours, in the final - 8 hours. 80% of the metabolites formed in the liver are excreted by the kidneys.

Indications

- premenstrual syndrome;

- anovulatory metrorrhagia;

- dysmenorrhea (accompanied by a shortening of the secretory phase);

- endometriosis;

- uterine fibroids;

- mastodynia;

- endometrial hyperplasia;

- diagnostic progesterone test;

- termination and prevention of lactation.

Contraindications

- puberty;

- jaundice (including history);

- acute liver diseases (including benign and malignant neoplasms);

- impaired liver and kidney function;

- hyperbilirubinemia;

- tendency to thrombosis;

- acute thrombophlebitis or thromboembolism;

- bleeding from the urinary tract of unknown origin;

- bleeding from the genital tract of unknown origin;

- cholestatic jaundice of pregnant women or skin itching in history;

- obesity;

- herpes;

- Hypersensitivity to the components of the drug.

Carefully: bronchial asthma, chronic insufficiency, epilepsy, arterial hypertension, migraine, renal failure, convulsions or other disorders of the central nervous system (including history), diabetes mellitus, liver disease (history), hyperlipidemia, history of thrombophlebitis, thromboembolism in anamnesis.

Dosage

Premenstrual syndrome, mastodynia, dysmenorrhea: in the period from the 16th to the 25th day of the menstrual cycle, 5-10 mg / day (1-2 tablets), can be taken with estrogen.

uterine fibroids: 5-10 mg / day from the 5th to the 25th day of the menstrual cycle for no more than 6 months.

Diagnostic progesterone test: the best option is to prescribe 10 mg of the drug for 10 days. The reaction is regarded as natural if moderate spotting appeared 3-7 days after the end of the drug and persisted for 3-4 days.

Anovulatory metrorrhagia, endometrial hyperplasia(the dysfunctional nature of bleeding must be confirmed by histological analysis no more than 6 months before treatment): 5-10 mg / day (1-2 tablets) for 6-12 days. After achieving the desired effect between the 16th and 25th days of the cycle, 5-10 mg / day, usually together with estrogen, to prevent relapse.

Endometriosis: in the period from the 5th to the 25th day of the cycle, 5 mg / day for 6 months. Further treatment at the discretion of the doctor.

Lactation warning: in case of termination of pregnancy between the 16th and 28th weeks on the 1st day, take 15 mg (3 tablets), on the 2nd and 3rd days, take 10 mg / day (2 tablets), from 4 th to the 7th day, take 5 mg / day (1 tab.). In case of termination of pregnancy between the 28th and 36th weeks, on the 1st day, take 15 mg (3 tablets), from the 2nd to the 7th day, take 10 mg / day (2 tablets).

Cessation of lactation: from the 1st to the 3rd days, 20 mg / day is prescribed, from the 4th to the 7th - 15 mg / day, from the 8th to the 10th days - 10 mg / day.

Side effects

special instructions

Before starting treatment, it is necessary to exclude the presence of malignant neoplasms, to conduct a preliminary thorough gynecological, oncological examination and examination of the mammary glands.

To normalize the menstrual cycle, Norkolut is often prescribed. The ability of the drug to prevent the formation of follicles and increase the time of arrival of ovulation makes it possible to use it to delay menstruation or accelerate them.

The composition and action of the drug

The active ingredient in Norkolut is norethisterone.

The action of Norkolut is aimed at maintaining the secretory state of the uterine mucosa. Taking the drug blocks individual pituitary hormones and does not allow the maturation of a new egg when it leaves the ovary.

Indications for prescribing the drug

The following pathological conditions may be the reason for drug treatment:

• the presence of endometriosis;
• lack of ovulation;
• diseases of the mammary glands;
• delay of menstruation;
• uterine pathology.

Norkolut is taken if necessary to terminate pregnancy and stop lactation. It is also used as a contraceptive and during menopause to eliminate negative manifestations from the body. Norkolut is used in the presence of premenstrual syndrome and painful menstruation.

Reception features

Tablets are taken orally and washed down with a sufficient amount of water. The time of eating does not affect the effect of the drug. Dosage for various pathologies is individual.

During menstruation, the intake of Norkolut is stopped, because. the drug contributes to a significant increase in the volume of blood secretions, increased pain and the development of pathological changes in the uterine mucosa.

It is not recommended to drink alcoholic beverages during the course of treatment. If you still have to take alcohol, then you should not forget that more than 3-4 hours should elapse between taking Norkolut and drinking alcohol. Alcohol poses the greatest danger to the liver, which in such cases can hardly cope with the load.

When should the medicine not be used?

Attention should be paid to contraindications to drug therapy. According to the instructions for use, Norkolut is not approved for the treatment of the following health problems:

• elevated levels of bilirubin in the blood;
• acute and chronic liver pathologies;
• malignant tumors;
• the presence of herpes;
• overweight;
• any bleeding of unknown origin;
• individual intolerance to the components of the drug;
• bronchial asthma;
• inflammatory pathologies of the veins.

With caution, the drug is taken if there are such diseases:

• hypertension;
• epilepsy;
• functional failure of the kidneys;
• pathology of the endocrine system;
• heart failure;
• malfunctions of the central nervous system.

Before taking the drug, you should consult a doctor to avoid unwanted complications that pose a health hazard.

Possible side effect

When taking a course of drug therapy, side effects sometimes appear. Taking Norkolut often causes digestive disorders, manifested by bouts of nausea and vomiting, diarrhea and constipation.

Other negative phenomena are also noted:

• jumps in blood pressure;
• allergic rashes on the skin;
• increased hair growth;
• weight gain;
• the appearance of edema on the limbs;
• violation of the composition of the blood;
• vision problems;
• excess sebum on the skin.

During the course of treatment, the mammary glands often become coarse and there is an increase in the sensitivity of the nipples.

Taking the drug can cause malfunctions in the nervous system, accompanied by headaches, reduced sensitivity of the limbs, decreased performance and the development of fatigue.

Overdose

If during treatment aimed at delaying or accelerating menstruation, a pill is missed, it is allowed to exceed the norm next time. But in such cases, nausea and vomiting may occur. Rarely, vaginal bleeding develops.

The use of medicine to delay menstruation

How to use Norkolut to delay menstruation - a specialist will advise. Choosing the necessary treatment regimen, the doctor takes into account both the individual characteristics of the body and the presence of certain chronic diseases. Thanks to norethisterone, the thick layer of the endometrium is rejected later and menstruation is delayed.

To obtain a positive result, the drug begins to be taken 1 week before the onset of menstruation. The recommended dosage is 2 tablets per day. The duration of therapy is 12 days.

Such a treatment regimen allows you to postpone the critical days for one to one and a half weeks.

Acceptance and cancellation of Norkolut are carried out under the supervision of a specialist.

Application for delayed menstruation

If menstruation is absent for a long period, treatment is carried out with a medication for 5-10 days. After the abolition of Norkolut, menstruation begins within a week. But the drug should be taken only after the examination, because. a delay in menstruation can be caused by conception.

Norkolut during pregnancy and lactation

The active ingredient in the composition of the drug helps to stop lactation. Taking the drug reduces the production of milk in the mammary glands. Norkolut is used if natural feeding is not recommended for any reason.

The course of treatment is 10 days. The therapy is carried out in several stages. In the first 3 days, take one tablet 4 times a day. Then the daily dosage is reduced to 3 tablets and they are drunk for another 4 days. In the last period of treatment, they switch to taking the drug in the amount of 2 tablets per day.

Norkolut is used and, if necessary, to prevent lactation if premature birth occurs.

Medicine for contraception

Start using the drug from the 5th day after the onset of menstruation. Take half a tablet at bedtime for 21 days. Then make a seven-day pause and again resume the use of the drug. At the beginning of treatment, estrogen is also taken, which is selected individually by the attending physician.

Features of the menstrual cycle

Under the influence of tablets, as well as the causes that caused the violation or delay of menstruation, the nature of blood discharge may change. Therefore, before taking the drug, you should consult a doctor to distinguish the norm from the pathology.

During the reception

Under the influence of the active substance, natural blood discharge is observed, the amount of which decreases by the end of the cycle. Menstruation is scanty and ends in a short time. Such a course of it is the norm and should not cause concern in women.

Sometimes there are individual reactions of the body, which are manifested by nausea, vomiting, increased pain and swelling of the extremities. After the abolition of Norkolut, the cycle returns to normal.

After treatment

In most cases, the habitual nature of menstruation does not change. Sometimes there are very few outliers. This is facilitated by an increase in blood clotting, which is the result of the action of the drug.

Rarely, profuse bleeding is noted, which requires qualified assistance. Gynecologists attribute this condition to the side effects of the drug.

The bleeding may be darker in color, and the duration of menstruation is reduced. This condition after taking Norkolut often persists for several months. Then the usual schedule is restored.

Rarely, there are cases when menstruation does not occur after the end of treatment. With this option, you should consult a doctor to exclude pregnancy and adjust the treatment regimen.

drug interaction

Simultaneous administration of hepatic enzyme inducers leads to an increase in the action of norethisterone. With caution, the drug is taken in combination with other hormonal agents and drugs that affect blood clotting and the concentration of sugar in it.

• Phenobarbital;
• Rifampicin;
• Phenytoin;
• Cimetidine.

Norkolut's analogs

In therapy aimed at delaying menstruation, you can use other pharmacological agents that are similar in composition or effect on the body.

Among them:

• Depo Provera;
• Livial;
• Lactinet;
• Escaped;
• Orgametril;
• Utrozhestan;
• Duphaston;
• Indinol.

To exclude unwanted complications when choosing a drug, you should carefully study the instructions and focus on the individual tolerance of a particular drug.