Papaverine, indications for use, side effects and other important points. How long is papaverine absorbed How long does papaverine leave the body

Papaverine is a combined antispasmodic and antihypertensive drug with analgesic action.

The active ingredient (papaverine hydrochloride) has anticonvulsant, analgesic and antihypertensive effects.

The use of the drug increases blood flow, dilates the arteries, reduces the tone of the smooth muscles of the organs of the reproductive, respiratory, urinary system, reduces the tone of the vessels.

In addition, the drug has a hypotensive effect.

In medium doses, Papaverine has a mild effect on the central nervous system. In high doses, the drug has a sedative effect, reduces the excitability of the heart muscle, and slows down intracardiac conduction.

The manufacturer focuses on the fact that Papaverine is used for spasm of smooth muscles: peripheral vessels (with endarteritis), abdominal organs (with renal colic, pylorospasm, spastic colitis, cholecystitis), bronchi (with bronchospasm), heart (with angina pectoris in combination with other drugs), cerebral vessels.

Also, the drug is used for premedication as an adjuvant.

Way

Orally. Patients who have reached adulthood are prescribed 40-60 mg of the drug three to four times a day.

The maximum allowed to take 20 mg per dose and 60 mg per day.

Intramuscularly, intravenously, subcutaneously. V / m, s / c: injections of Papaverine are administered twice to four times a day, 1-2 ml of a two percent solution (which is equal to 20-40 mg).

In / in the drug is administered slowly at 20 mg, which is equal to 1 ml. Before use, a two percent solution is diluted in an isotonic sodium chloride solution with a volume of 10-20 ml.

Release form, composition

Papaverine is produced in three forms:

The composition of the drug is determined by the form of release.

Injection:

papaverine hydrochloride - per 1 ml of medicinal liquid 20 mg;
edetate disodium;
D,L-methionine;
water for injections.

Suppositories rectal:

papaverine hydrochloride - 0.02 g in a suppository weighing 1.25 g;
cosmetic stearin;
emulsifier No. 1;
hard fat.

Tablets:

papaverine hydrochloride - in 1 tablet 10 mg;
potato starch;
rafinated sugar;
talc;
stearic acid.

Interaction with other drugs

Often Papaverine is used together with Platifillin - an antispasmodic, sedative and vasodilator, that is, a drug close to Papaverine in terms of pharmacological abilities.

The possibility of using these drugs in combination is explained by different mechanisms of therapeutic action.

That is why drugs are often used in the conservative rehabilitation of hypertensive crises, spastic syndromes, and other pathological conditions.

It interacts well with Papaverine No-shpa: the use of these drugs in combination has a synergistic therapeutic effect on the smooth muscles of the body.

Especially often, these drugs are used in gynecological and obstetric hospitals with the threat of spontaneous miscarriage, uterine tone, too active early labor.

In some medical publications, there is information that in combined conservative therapy, the effectiveness of Levodopa is reduced.

Therefore, it is contraindicated to use Papaverine in the form of an injection solution or tablets during the drug treatment of Parkinson's disease.

The combined use of Papaverine and anticholinergic drugs can lead to an increase in the therapeutic effect of the latter. Therefore, if it is necessary to use these drugs simultaneously, it is necessary to discuss with the doctor the issue of reducing the dosage or temporarily canceling therapy.

Side effects

Different body systems can react to the use of Papaverine in different ways:

Contraindications

According to the instructions, the drug should not be used in children under six months of age and the elderly, as well as with:

severe liver failure;
AV blockade;
hypersensitivity to the components of drugs;
glaucoma.

With caution, the drug is used for:

suffered traumatic brain injury;
chronic renal failure;
supraventricular tachycardia;
hypothyroidism;
adrenal insufficiency;
states of shock;
prostatic hyperplasia.

During treatment with Papaverine, it is necessary to stop drinking alcohol.

During pregnancy

The safety of using Papaverine during lactation and during pregnancy has not been established, therefore, lactating and pregnant women can take the drug only with the permission of a doctor.

Terms and conditions of storage

The manufacturer of Papaverine recommends storing the product in a well-packed container at a temperature of less than 25 degrees.

For storage, choose a room protected from direct sunlight and moisture.

Price

Average price in Russia. The drug, well known among doctors, is often used in clinical practice. At the same time, Papaverine is considered an inexpensive drug.

The cost of the drug depends on the form of release. On average, you can buy it for 10-60 rubles.

Average cost in Ukraine. As for Ukrainian pharmacies, they sell medicine for 6-25 hryvnias.

Analogues

Papaverine analogues include various pharmaceutical forms of drugs in which it can be found on the shelves of pharmacies.

This is done so that the patient can choose an analogue if a certain dosage form does not suit him.

In the same way, you can replace Papaverine, but before that, you should consult with a medical practitioner.

A similar antispasmodic effect is exerted by Drotaverine Hydrochloride, known to a wide audience under the name No-shpa. It can be used to treat patients in a urological / proctological hospital, pregnant women, children, as well as to relieve headaches at home.

What is Papaverine? This is a drug known for a very long time. It is used as an antispasmodic in many countries. In the language of professionals, it is called Papaverine hydrochloride. It can be purchased at the pharmacy in several dosage forms. It can be tablets, suppositories or a solution. Its shelf life is 2 years. When visiting a pharmacy, it must be borne in mind that candles and tablets are on sale, and to buy a solution, you will need a prescription confirming the appointment.

How the remedy works

Papaverine can be prescribed in two cases: to reduce pressure in the body; to relieve muscle pain during spasms.

Its main substance is able to affect certain enzymes, so the muscles of the internal organs relax. This helps relieve pain in the digestive organs, blood vessels or lungs. Pain passes, pressure begins to fall. If the dose of the drug is slightly increased, then a calming effect will also appear. Very often it is used in preparing a person for an operation that will take place under general anesthesia.

When using Papaverine, it is rapidly distributed in the body through the blood, regardless of the form used. The breakdown products of this drug are excreted through the urine.

It is usually prescribed to patients with various diseases. The form is chosen the most convenient for use.

But sometimes injections are preferred: with a sharp change in blood pressure; with severe bowel disorder; if the body temperature rises sharply; in case of loss of consciousness by a patient who needs urgent help. When is the use of Papaverine recommended: for stomach pain; with intestinal and gastric colic; in case of constipation or disorders; with menstrual pain; with spasms in the bladder or its inflammation; with a sharp contraction of the muscles of the bronchial wall; in case of vasospasm in the brain area.

With individual characteristics, the doctor can use this drug:

with colic in the kidneys; with inflammation of the gallbladder; for pain in the chest.

Sometimes it can be prescribed together with Dibazol. This helps reduce pressure. In this case, you need to give an injection intravenously or intramuscularly.

He is also prescribed together with Analgin in ampoules. This helps to normalize body temperature, relieve the patient of pain. Such appointments will be relevant for patients who have undergone surgery.

How the use depends on the form: The tablet form is used if necessary at any time and washed down well with plain water. Injections with Papaverine can be done subcutaneously or into the muscle. It is best that this is done by a medical worker in a hospital, subject to all sanitary standards. If it is administered intravenously, then it must be diluted with saline. Candles are usually used for pain in the pelvic organs. They need to be inserted into the anus.

So, Papaverine is an antispasmodic, which is available in three different forms (tablets, rectal suppositories and solution in ampoules). The choice in favor of one form or another is made by the doctor based on a number of parameters.

Dosage and possible contraindications

Papaverine has strict restrictions on admission. It should not be used to treat young children under 6 months of age. The same rule applies to people who are over 65 years of age.

Who else is contraindicated Papaverine: in violation of the kidneys; with abnormal liver function; with the development of glaucoma; with heart block; with a rapid heartbeat; in case of malfunction of the thyroid gland; with brain injuries.

The dosage should be determined by the doctor in each case. Usually the remedy is not used for a long time, but only if necessary. In the absence of the desired result and if the pain does not stop, then be sure to go to the hospital.

For adult patients, the dose should not exceed 60 mg, if necessary, it can be no more than 240 mg at a time and 720 mg per day.

For medicinal purposes, the doctor may prescribe: 3 or 4 tablets per day; 2 or 3 candles a day; 2 or 4 injections per day.

The form of choice depends on a set of conditions.

Usually Papaverine is taken for about 5 days, but if there is a need and recommendation of a specialist, the period can be extended to 21 days. The action of Papaverine in the form of tablets will be the same as when using a solution.

Use by pregnant women and children

Sometimes the drug is used to treat children.

The description for the drug sets the dosage depending on age: from 6 months to 2 years, you can take no more than 5 mg; from 2 to 7 years, the dose should not exceed 10 mg; upon reaching 10 years, it can be no more than 15 mg; from 10 to 14 years old, it can increase to 20 mg.

For convenience, you can purchase tablets with a dosage of 10 mg. If you need to use candles, they can be divided in half. For adults, Papaverine 40 mg is suitable.

During pregnancy, it can only be used as directed by a doctor. Papaverine is not able to affect the course of pregnancy, but still it is better not to risk it, especially in the later stages.

What can provoke the drug when used in large doses: Violation of the intestines. A sharp drop in blood pressure. Nausea. Increased sweating. General weakness and increased drowsiness. Thrombus formation. Changes in the composition of the blood. Violation of the heart rhythm. Allergy development.

Sometimes a large amount of Papaverine can provoke a deterioration in vision, the appearance of a split effect.

To get rid of any side effects, you need to stop taking the remedy and flush the stomach. When used correctly, this medicine can help in the treatment of complex diseases.

Injection:

papaverine hydrochloride - 20 mg per 1 ml of medicinal liquid;
D,L-methionine;
disodium edetate;
water for injections.

Tablets:

papaverine hydrochloride - 10 mg in 1 tablet;
rafinated sugar;
potato starch;
stearic acid;
talc.

Rectal suppositories:

papaverine hydrochloride - 0.02 g in 1 candle weighing 1.25 g;
emulsifier No. 1;
cosmetic stearin;
solid fat.

Release form

papaverine tablets 0.01 g or 0.04 g each, depending on the target audience of patients (the former are used in pediatric practice after 6 months), which are packaged in blisters of 10 pieces. The oral form has a slightly bitter taste, white color and no smell at all.
Solution for injection 2% in ampoules of 2 ml. A carton usually contains 10 pieces and instructions for the use of a pharmaceutical product.
Rectal suppositories or suppositories for introduction into the rectum, 0.02 g each; fixed in PVC or aluminum foil blisters of 10 pieces. A plate with a medicinal product and an annotation are placed in a cardboard box.

pharmachologic effect

papaverine hydrochloride (Wikipedia indicates that the INN of the drug corresponds to the name of the main active ingredient) is opium alkaloid , acting on smooth muscle elements and causing them to relax, therefore the pharmacological group of the drug is defined as myotropic antispasmodics .

The mechanism of the therapeutic action of a biological substance is to influence the secondary mediators (messengers) of the transmission of muscle excitation. Papaverine inhibits PDE (phosphodiesterase), due to which the cell accumulates cAMP (cycloadenosine monophosphate) and the content of ions decreases calcium , in response to such biochemical changes, the smooth muscles of the internal organs (digestive tube, respiratory and genitourinary systems and vascular bed) relax, their tone decreases. .

A pharmacopoeia is a set of mandatory rules and official regulations that guide the manufacture, testing, storage and administration of medicines to patients. Since the main biologically active component of the pharmaceutical preparation is potent, in relation to Papaverine hydrochloride, the pharmacopoeia includes the following points for determining the authenticity of a chemical:

physical characteristics- white crystalline powder, odorless, with a slightly bitter taste.
Solubility- dissolves in water for 40 hours, slightly soluble in 95% alcohol, soluble in chloroform and practically insoluble in ether.
Acidity 2% solution of Papaverine hydrochloride - 3.0-4.5 (determined by the potentiometric method).
Chemical Authentication- 0.05 g of the pharmaceutical preparation is placed in a porcelain bowl, moistened with a couple of drops of high concentration nitric acid, after which a yellow color should appear, which changes to orange when heated in a water bath.
The presence of organic impurities– test of dissolution and color change in 5 ml of concentrated sulfuric acid.

Pharmacodynamics and pharmacokinetics

The active component is quickly and almost completely absorbed by any route of administration of the drug into the body. Once in the bloodstream, it binds to plasma proteins (90% of the total biologically active substance), due to which it easily passes through histohematic barriers. Biotransformation undergoes in the liver. The half-life is from 30 minutes to 2 hours, depending on the auxiliary components of the pharmaceutical preparation. It is excreted mainly by the kidneys in the form of metabolic products.

Indications for use Papaverine

spasm of smooth muscles abdominal organs (especially often with , spastic or pylorospasm );
hypertensive crisis (in combined conservative therapy);
endarteritis ;
spasm of the peripheral vascular bed;
decrease in the lumen of the cerebral vessels due to contraction of the muscular layer of the arteries;
bronchospasm ;
reduction of arterial renal inflow of vascular origin;
urinary retention due to spasm of the urinary tract.

Indications for use also include the stage premedication before surgical interventions in the abdominal cavity, proctological and urological manipulations. What is used for - relaxation of smooth muscle elements (for more details, see the paragraph "Pharmacological action").

Contraindications

intolerance to the constituent components of the drug;
intracardiac conduction disorders, especially atrioventricular block ;
hypersensitivity to a pharmaceutical preparation;
heavy liver failure ;
advanced age (since there is a significant risk of developing hyperthermic syndrome);
children's age up to 6 months.

Additional restrictions on use (recommended to use only under the constant supervision of qualified medical professionals and regular diagnostic examinations):

recent traumatic brain injury in history;
chronic;
shock conditions;
supraventricular ;
benign ;
lack of functionality of the adrenal glands.

Side effects

From the side cardiovascular system and blood: atrioventricular block , ventricular tachycardia , decrease .
From the side gastrointestinal tract: nausea , constipation (),bloating , violation of the passage through the digestive tube, increased activity of hepatic transaminases.
Other: , , eosinophilia .

Instructions for use Papaverine (Method and dosage)

Tablets Papaverine, instructions for use

In tablets, a pharmaceutical preparation can be prescribed to both adults and children, even the frequency of administration does not change and is 3-4 times a day. The dosage of the oral form of the drug depends on the age category of the patient, the following treatment regimen is used:

from 6 months to 2 years - 0.005 g per reception;
3-4 years - 0.005-0.01 g;
5-6 years - 0.01 g;
7-9 years - 0.01-0.015 g;
10-14 years old - 0.015-0.02 g;
adults - 0.04-0.08 g per reception.

Candles Papaverine, instructions for use

is an extremely unpleasant proctological disease, which is associated with , inflammatory processes and pathological expansion of the hemorrhoidal veins surrounding the lumen of the rectum. This nosological unit is characterized by typical clinical picture , which includes impaired defecation, itching, bleeding from the anus. Candles with Papaverine will help to alleviate the course of the disease.

The active components of the pharmaceutical preparation allow you to relax smooth muscle elements of the intestine , which facilitates the process of bowel movement, because the lumen of the rectum increases slightly. For the same reason, bleeding is stopped, since solid fecal masses do not injure inflamed hemorrhoids, therefore, suppositories with Papaverine for hemorrhoids are a kind of “magic wand”.

In pharmacy kiosks, you can find suppositories with different dosages of biologically active substances. A course of conservative sanitation should be started with 0.02 g, gradually increasing it to 0.04 g, if a smaller amount of the pharmaceutical preparation does not have its therapeutic effect. It is not recommended to use more than 3 suppositories per day, this is fraught with the development of adverse side effects and even a state of overdose, since all incoming drugs are absorbed extremely well in the rectal region.

How to use Papaverine Hydrochloride injection solution?

The active component of the pharmaceutical preparation has a high bioavailability, therefore, injections can be done both subcutaneously and intramuscularly, as well as intravenously, the therapeutic capabilities of the drug will not suffer from this, and the end result will be just as strong. However, it should be determined that subcutaneous injections of Papaverine hydrochloride are recommended for use not in the distal part of the forearm, but in the shoulder or in the outer surface of the thigh, since the frequency of administration can ensure the appearance of a hematoma. Intramuscular injections of Papaverine can be carried out according to the standard scheme, that is, use the upper lateral quadrant of the buttock.

Before making intravenous injections, the amount of the pharmaceutical preparation prescribed by the doctor should be diluted with 10-20 ml of isotonic solution sodium chloride . It should also be remembered that Papaverine hydrochloride should be administered very slowly so as not to cause discomfort in the patient during the injection process.

Subcutaneously, as a rule, the contents of 1 ampoule (2 ml) of a 2% solution of Papaverine Hydrochloride are injected.

Dosage of the solution in ampoules for intravenous and intramuscular administration:

adults: single - 0.1 g, daily - 0.3;
children from 6 months to 1 year: single - 0.005 g, daily - 0.01 g;
at the age of 2 years: single - 0.01 g, daily - 0.02 g;
3-4 years: single - 0.015 g, daily - 0.03 g;
5-6 years: single - 0.02 g, daily - 0.04 g;
7-9 years: single - 0.03 g, daily 0.06 g;
10-14 years old: single - 0.06-0.06 g, daily - 0.1-0.2 g.

Dibazol with Papaverine - how to use?

- this is antihypertensive medicinal product from the group of peripheral vasodilators , that is, the active components of the pharmaceutical preparation have a vasodilating effect and significantly contribute to lowering blood pressure. Papaverine has similar therapeutic properties in relation to the vascular system, therefore the combination of these drugs is actively used by emergency medical workers to eliminate hypertensive crisis .

Dibazol is administered with Papaverine intramuscularly or intravenously, because in this way the necessary pharmacological effects of the active ingredients develop much faster than with oral or any other method of use. The relaxing effect of biologically active components can be combined with physiotherapeutic methods, for example, a horizontal position with the lowered foot end, warm foot baths, massage of the lower extremities, and so on.

The dosage of Dibazol with Papaverine for the elimination of a hypertensive crisis is 3-5 ml of a 1% solution of Dibazol and 2 ml (contents of 1 ampoule) of a 2% solution of the second pharmaceutical preparation. Such a large number of active ingredients can not only reduce blood pressure, but also stop the feeling of nausea, pain in the heart and some other manifestations of cardiovascular pathology.

Overdose

Possible symptoms with active ingredients of the medicinal product:

diplopia (double vision) ;
weakness;
lowering blood pressure ;
increased fatigue .

Specific pharmaceutical no, because it applies detoxification therapy and symptomatic treatment . Especially effective is gastric lavage or the use of sorbents ( milk , , for example) in the first hours after taking oral forms of papaverine hydrochloride. Also, in case of drug overdose, it is important to constantly monitor and, if necessary, artificially maintain blood pressure.

Interaction

- it is an antispasmodic, vasodilator, sedative, that is, in terms of pharmacological abilities, it is close to Papaverine. Medicines differ only in the mechanisms of therapeutic action, because Platifillin with Papaverine are used in the combined conservative rehabilitation of spastic syndromes, hypertensive crises and other pathological conditions.

with Papaverine, like Platifillin, they interact well, providing a synergistic therapeutic effect on the smooth muscle elements of the human body. This combination of pharmaceuticals is especially common in obstetric and gynecological hospitals with uterine tone, the threat of spontaneous miscarriage, or excessive early labor activity.

In medical publications on neurological subjects, there is news that the effectiveness of the use of Levodopa significantly decreases in combined conservative therapy, from which Papaverine in tablets or in the form of a solution for injection against the background of medical sanitation use is contraindicated.

Simultaneous use of papaverine with anticholinergic drugs may manifest itself in an increase in the therapeutic effects of the latter, therefore, if necessary, their combined use should be discussed with a dose reduction or temporary withdrawal of pharmaceuticals with a qualified specialist.

Terms of sale

The pharmaceutical preparation has been known since time immemorial and has always been famous for the strength of its therapeutic effect, therefore, in the past, when buying it, pharmacy kiosks required a prescription in Latin. Now the procedure for acquiring Papaverine has become much easier, however, it is the responsibility of the patient to present a prescription that is correctly executed and certified by the attending physician.

Storage conditions

In a dry, protected from direct sunlight place at a temperature not exceeding 25 degrees Celsius in a tightly packed container. The pharmaceutical product belongs to list B, so its storage should be carefully monitored.

Best before date

special instructions

Papaverine hydrochloride significantly improves peripheral circulation, which improves trophic processes in individual organs when used locally. This therapeutic ability determines the use of a pharmaceutical preparation in bodybuilding . Practical observations of athletes show that it is most effective to use the drug to increase the specific gravity of the deltoid and biceps muscles.

The goal of athletes is a local effect on a certain part of the muscles, from which injections are carried out intramuscularly. The optimal dosage is 1-2 injections per week, which are carried out 15-20 minutes before intense training. Further, at the very beginning of physical exercises, all efforts should be aimed at the “enriched” muscle, that is, exercised according to the “pumping” (blood pumping) system, since the therapeutic effect of Papaverine when used locally is short-lived.

The ingenuity and resourcefulness of the female half of humanity is not far behind the stronger sex, because Papaverine hydrochloride is used even in cosmetic procedures and home skin care. Due to the increased blood circulation of the peripheral parts of the body under the action of a pharmaceutical preparation, the excretion of accumulated fluid improves, puffiness is removed and metabolic processes are stimulated to some extent. Such therapeutic effects allow the use of the drug to combat cellulite , the elimination of the unpleasant "orange peel" in the buttocks and back of the thigh, and even getting rid of a couple of extra pounds.

To obtain such a result, leading cosmetologists recommend using caffeine and papaverine wrap , which can be carried out even at home. To prepare a miraculous mixture, you will need 2 ampoules of Caffeine benzoate 2 ml each, 2 ampoules of Papaverine hydrochloride 2 ml each and a small amount of non-candied honey. Before applying the cosmetic product, the skin should be prepared, for which light peeling, scrub or a small local massage are used.

The mixture should be applied evenly over the entire area of the treated surface in a small layer. The cosmetic product will not be absorbed immediately, therefore it is necessary to tightly cover the skin with plastic wrap (food wrap is ideal for this purpose) and warm yourself by wrapping yourself in a wadded blanket or using winter clothes. It is recommended to wrap for at least an hour, then wash off the remnants of the mixture with warm water and apply a moisturizing or nourishing cream. The duration of the course is twelve procedures, and the frequency of their implementation is every other day.

The active components of the pharmaceutical preparation spread their beneficial effects not only on people, but also on animals, therefore Papaverine has found wide application in veterinary practice . Especially often, the drug is used for cats, as pets end up in hospitals due to spasms of the smooth muscles of the intestine. The etiological factor is the feline hygiene procedures, because in the process of “washing”, as a rule, some amount of wool is swallowed. Papaverine facilitates the discharge of the contents of the digestive tube.

Analogues

Coincidence in the ATX code of the 4th level:

Papaverine analogues are a variety of pharmaceutical forms of the drug in which it is found on pharmacy shelves. As a rule, one of the forms does not suit the patient and then another one should be selected. It is also possible to replace this product, but you should first consult with a qualified specialist in this field, because the basic principle of medicine “do no harm” can easily be violated by ignorance.

A pharmaceutical drug with an international non-proprietary name has a similar antispasmodic effect. , which is known to a wide audience under the name . It can also be used for pregnant women, and for patients in a proctological or urological hospital, and for children in pediatric practice, and for the treatment of headaches at home.

children

Papaverine hydrochloride is actively used in pediatric practice, starting from the age of 6 months.

Papaverine during pregnancy and lactation

What are Papaverine suppositories for during pregnancy?

The uterus, the organ of the female reproductive system, in which the intrauterine phase of fetal development takes place directly, has both striated muscles and smooth muscles in its composition. In the process of bearing a child, an increased tone of this organ often develops, as a result of which spastic pains are possible, early contractions , premature rupture of amniotic fluid and not being born on time. Papaverine hydrochloride has a relaxing effect, which allows you to remove the above manifestations of uterine hypertonicity.

Of course, before using the drug, you should decide on a pharmaceutical form that will have maximum beneficial effects and will not harm the developing body of the child and mother. For pregnant women, the appropriateness of using one form or another of Papaverine is determined duration of gestation , for example, in the early stages it is recommended to use oral tablets, and in the later stages, intramuscular and subcutaneous administration of injection solutions shows itself much better.

Candles with papaverine during pregnancy

First of all, you should decide on a completely logical question for patients - where to insert Papaverine suppositories during pregnancy, because, as a rule, this pharmaceutical form of the drug is used rectally , however, the therapeutic effect is required not in the final sections of the gastrointestinal tract, but in the muscle elements of the genitourinary system. This misconception is typical of women who are completely unfamiliar with the principle of operation of local pharmaceutical suppositories.

After the introduction of Papaverine, the active components of the suppositories are actively absorbed and carried first local blood flow by nearby organs, due to which the smooth muscle elements of the uterus are fully supplied with biologically active substances. Another positive aspect of the use of this pharmaceutical form is the high bioavailability of rectal suppositories, that is, a large percentage of the drug enters the microcirculatory bed, and is not excreted from out.

Injections during pregnancy

Of course, the most effective way to use Papaverine hydrochloride is its intramuscular or even intravenous administration, because in this way bioavailability drug tends to maximum, and the concentration of the active substance remains at the highest point for the longest period of time.
It should be emphasized that the injectable form of the pharmaceutical preparation is especially relevant in late pregnancy, when uterine hypertonicity or spastic, cramping pains can lead to premature onset of labor and discharge of amniotic fluid. If there are relevant indications from the attending physician, it is worth thinking about inpatient treatment, because in this case the pregnant woman will be under the constant supervision of medical personnel, which cannot but inspire confidence.

The dosage of the solution for injection, as well as the frequency of use of the pharmaceutical preparation, is selected individually, as a rule, it ranges from 1 to 10 ml of 2% of the drug 2-4 times a day. If adverse effects of conservative sanitation occur, you should immediately contact a qualified specialist.

Papaverine Hydrochloride tablets, instructions for pregnancy

Since special medical knowledge and skills are required to inject a pharmaceutical preparation, and rectal suppositories can cause certain inconvenience and discomfort during their use, these pharmaceutical forms of Papaverine are often replaced with tablets that are administered orally. Of course, the effectiveness of such conservative therapy is somewhat lower than that of other ways of introducing the active ingredient into the body, however, from the side of everyday use, tablets have no equal.

Papaverine hydrochloride in oral form is used exclusively according to indications, and the criterion for its use is the subjective well-being of the pregnant woman, therefore there is no strict dosage of the pharmaceutical preparation. Specialists in obstetrics and gynecology do not recommend taking more than 4 tablets per day, which should be used 2 hours before meals in order to increase the pharmacokinetic abilities of the active ingredient.

Papaverine is an effective antispasmodic that is widely used in medical practice for various diseases. Papaverine suppositories are used for pathologies accompanied by spasm of the smooth muscles of hollow organs, for example, with cholecystitis, renal colic, spastic colitis, bronchospasm, endarteritis, migraines and many other diseases. When administered rectally, the drug is rapidly absorbed and its active components enter the bloodstream. The therapeutic effect comes quickly enough.

Compound

Papaverine is available in several dosage forms. These are tablets, injection solution and rectal suppositories. Many experts argue that it is Papaverine suppositories that are the safest form of release. The composition of one candle includes 20 mg of the active ingredient - papaverine hydrochloride.

drug properties

Candles of papaverine hydrochloride after injection into the rectum affect the smooth muscles of the bronchi, lungs, large and small intestines, stomach, uterus. In this case, the effect of the drug does not apply to the muscles of the skeleton and heart. After the drug enters the body, these muscles work in the usual way.

Product properties:

elimination of smooth muscle tone in various pathologies;
lowering blood pressure, vasodilatation;
increased blood flow in all internal organs;
normalization of the heart rhythm;
providing a sedative effect.

During childbirth, women are prescribed Papaverine suppositories to relieve cervical hypertonicity. Many are interested in how to administer the drug vaginally or rectally? Suppositories Papaverine is injected into the patient's anus.

Indications

What is the medicine used for? Papaverine suppositories are used for many diseases that are accompanied by pain. The drug is widely used in gynecology, urology, surgery.

Main indications:

all types and stages of hemorrhoids;
headaches caused by vasospasm;
pain syndrome in various diseases of the digestive system;
renal colic;
pathologies of the urinary tract - pyelonephritis, cystitis, urolithiasis, urethritis;
bronchitis, pneumonia;
pain in women during menstruation.

Papaverine helps relieve spasm in various diseases

Suppositories Papaverine have a positive effect on the organs of the gastrointestinal tract with constipation, contribute to the normalization of the stool. Effectively fights the drug with migraines. With bronchitis, the medicine relieves spasm from the bronchi, helps prevent swelling of the mucous membrane.

Mechanism of action

The therapeutic effect of suppositories Papaverine is provided by the suppression of the phosphodiesterase enzyme. Thanks to this, it is possible to relieve muscle spasm, relax muscle fibers. The drug has an effect on the genitourinary, digestive, hepatobiliary system of a person, and also relieves vasospasm. The active ingredient papaverine hydrochloride increases the lumen of blood vessels, thereby normalizing systemic blood pressure. After the introduction of the drug, its active ingredient quickly penetrates into the bloodstream. Papaverine hydrochloride is evenly distributed throughout the body, affecting the central nervous system.

Important! During use during pregnancy, the drug can cross the placenta to the fetus, enter the milk during breastfeeding.

Contraindications

Instructions for use include a number of contraindications that must be taken into account when using the drug. These include:

the presence of an allergy to the components of the drug;
increased intraocular pressure in glaucoma and other diseases;
liver failure, accompanied by a severe course;
blockade of the heart muscle;
advanced age of the patient;
children's age up to 12 years.

Papaverine is prescribed by a doctor who must study the patient's medical history, exclude all possible contraindications.

How to put candles

Where to insert papaverine cuts and how often can this be done? Use suppositories should only be prescribed by a doctor. Usually, adults are administered 20-40 mg of the drug 2-3 times a day. Sometimes a specialist can adjust the dosage depending on the diagnosis. Considering the question of how long the drug acts, it should be noted that, on average, the effect occurs after 30-40 minutes. Sometimes the result has to wait longer. It depends on the characteristics of the course of the disease and the individual qualities of the body.

The candle should be inserted in accordance with the instructions.

With uterine hypertonicity

Increased uterine tone threatens premature birth. Papaverine suppositories help relieve spasm, relax smooth muscles. On the recommendation of a doctor, a woman is given 2-3 suppositories throughout the day with uterine tone. It is advisable for every pregnant woman to have this medicine in her home medicine cabinet, since when a spasm occurs, this drug will become an ambulance. The drug should be carefully used during treatment with other vaginal and rectal suppositories.

Sometimes the medicine is used among women in labor with false contractions. During this period, a woman experiences pain in the uterus and lower back, but this condition is only a harbinger of an early birth. To facilitate the well-being of a woman, candles can be prescribed.

Treatment of prostatitis

With prostatitis, Papaverine helps to eliminate pain and unpleasant pulling sensations. During the period of exacerbation, candles are inserted into the anus, 1 - 2 pcs. three times a day. Before starting treatment, it is important to make sure that there is no allergy to any of the components of the product.

papaverine for hemorrhoids

How to put suppositories Papaverine for hemorrhoids? As with other diseases, suppositories are used rectally. The dosage for a particular patient is selected by the doctor, taking into account the characteristics of the course of the disease, the type and stage of the disease. Usually the dose of medication for varicose veins in the anus is 1-2 suppositories three times a day. The duration of therapy depends on the achieved therapeutic effect.

Use of papaverine among children

Papaverine for children is used under the strict supervision of the attending physician. The instructions for use say that the drug is prescribed to children who have reached the age of 12 years, but in some cases a specialist may prescribe the drug to a child who has not reached this age.

The drug is used with caution among children

Possible side effects

Negative phenomena against the background of the use of suppositories are extremely rare. This is evidenced by the numerous positive reviews of patients and doctors who have tested the drug in practice. Sometimes during treatment with the remedy there is a slight itching and irritation in the anus. If the dose is greatly exceeded, the patient may experience the following complications:

violation of the heart rhythm;
dizziness;
apathy and drowsiness;
difficulty in urination and defecation;
nausea, rarely vomiting.

Treatment of the above complications is to purify the blood and symptomatic therapy of the patient.

Important! With the development of alarming signs during therapy with Papaverine, you should stop taking the remedy, immediately visit a doctor.

Combination with other medicines

With the simultaneous use of Papaverine with antihypertensive drugs, the effect of the latter is enhanced. The antispasmodic effect of papaverine hydrochloride increases while taking barbiturates. The hypotensive effect of the drug increases with simultaneous administration with drugs such as tricyclic antidepressants, Quinidine, Procainamide, Reserpine.

special instructions

When starting treatment with the drug, you should carefully study the instructions for use. It includes several special instructions that must be observed. These include:

with extreme caution, the drug should be used in severe renal failure;
for the period of treatment with suppositories, it is important to refuse to take alcoholic beverages;
during pregnancy and lactation, candles are used under the strict supervision of a doctor. To date, there is not enough information about the safety of the drug during this period;
the active component of the drug can have a relaxing effect on the central nervous system, so among people whose work requires increased concentration of attention, the drug is used with caution.

In addition, if the patient is taking any other medications, be sure to inform the doctor.

Before starting treatment, it is important to read the instructions for the drug.

Drug analogues

How to replace candles Papaverine? Among the analogues of the drug, the following agents can be distinguished:

No-Shpa is a drug that is used in diseases associated with spasm of smooth muscles of internal organs and blood vessels, as well as in the treatment of periodic pain;
suppositories Spasmolysin - are inserted into the anus with pain syndrome that occurs against the background of diseases of the gastrointestinal tract and other organs, with cholecystitis, pancreatitis, cystitis and other pathologies;
Spascuprel - used to relax the smooth muscles of internal organs in diseases of the stomach, intestines, pancreas, kidneys and other organs;
Teofedrin ІС - is used for bronchial asthma, obstructive bronchitis to eliminate bronchospasm, facilitate the patient's breathing;
GastroComfort - antispasmodic and carminative, which is prescribed to patients with diseases of the digestive system;
Niaspam - is used for irritable bowel syndrome, with renal and hepatic colic, and other pathologies of the digestive system.

Any of the analogues should be taken only after examination by a doctor.

Self-medication often causes serious negative consequences.

Terms of sale and storage

Papaverine suppositories are dispensed from a pharmacy by prescription. It is recommended to store the medicine in a place where the sun's rays do not penetrate. Shelf life is 3 years, subject to the recommendations for storing the drug. After this period, the product cannot be used.

In this regard, the drug has antispasmodic, analgesic and hypotensive effects. How does Papaverine work, what properties does it have and to whom is it indicated?

History reference

Papaverine was first isolated from the opium poppy by German chemistry student Heinrich Merck in 1848. Only 52 years later, in Sweden, Ame Pictet synthesized artificial papaverine from methylated vanillin and benzoylglycine.

In the early 10s of the last century, the alkaloid was found to have antispasmodic properties and was introduced into clinical practice for the treatment of bronchial obstruction and coronary heart disease. Later, Papaverine is prescribed as an antihypertensive agent, as well as to relieve spasms of internal organs. In 1930, the Hungarian pharmaceutical company Quinon began mass production of Papaverine.

Pharmacokinetics of the drug

The drug is produced only in the form of a hydrochloric acid compound - papaverine hydrochloride. It has a relatively low bioavailability. However, it almost completely binds to blood proteins and is evenly distributed throughout the body. The main functions of an antispasmodic and antihypertensive agent papaverine is due to:

inhibition of phosphodiesterase activity;
increased concentration of intracellular cycloadenosine monophosphate;
decrease in the level of calcium inside the cell.

Alkaloid reduces tone and relaxes the smooth muscle layer of internal organs and blood vessels. Thus, Papaverine is a vasodilator, antispasmodic and hypotensive agent.

Important! Chronic and acute alcohol intoxication reduces the vasodilating properties of Papaverine. Therefore, the intake of alcohol during treatment with an alkaloid is excluded.

Release form, storage conditions and dispensing from the pharmacy

How quickly Papaverine acts depends on the form of release of the drug. Papaverine is available as:

injection solution;
tablets;
rectal suppositories.

Tablet forms do not act as quickly as candles. However, if it is necessary to achieve the maximum result of the drug in the shortest possible time, injectable forms are more often used, for which Papaverine is injected subcutaneously, intramuscularly or intravenously.

The effect of papaverine, as a rule, is not long-lasting. From the pharmacy, the injection solution is dispensed by prescription, tablets and suppositories are over-the-counter. Papaverine is stored in a dry, dark place out of the reach of children. The temperature regime for tablets varies from 8 to 25 ºС, for injections ºС, for rectal suppositories up to 15 ºС.

Indications and dosage regimen

In clinical practice, the drug is widely used as an antispasmodic, vasodilator, analgesic and antihypertensive agent. Here are the conditions from which Papaverine helps:

involuntary contractions of the smooth muscle layer (spasms) of internal organs with cholecystitis, pancreatitis, colitis;
renal colic;
spastic endarteritis;
bronchospasm;
spasm of cerebral vessels.

In addition, Papaverine is used as part of complex therapy for coronary heart disease, acute hypertensive crisis, as well as for premedication before surgical interventions. The use of papaverine in uterine hypertonicity remains a controversial issue. The safety of the drug during pregnancy and lactation has not been proven. However, domestic doctors sometimes resort to the use of Papaverine in case of a threatened miscarriage.

Doses are selected individually depending on the purpose of prescribing the drug. In this case, both the characteristics of the disease and the state of the organism itself are taken into account. Only a competent specialist can accurately indicate how to take Papaverine in a particular case. The maximum single dose of papaverine is:

for tablet forms - 200 mg;
for subcutaneous and intramuscular injections - 40 mg;
for intravenous infusions - 20 mg;
for rectal administration - 40 mg.

Contraindications and side effects

The main restrictions on the prescription of the drug are:

hypersensitivity;
pathology of the conduction system of the heart (atrioventricular blockade);
severe liver failure;
elderly age;
children under 6 months;
severe kidney disease;
bronchial obstruction.

Undesirable effects when using papaverine can be:

headache;
nausea;
drowsiness;
drop in blood pressure;
atrioventricular block;
extrasystole;
eosinophilia;
dyspeptic disorders.

Acute arrhythmias, double vision, vomiting, profuse sweat may indicate a case of overdose with Papaverine, for which gastric lavage and enterosorbents are prescribed.

How fast do papaverine suppositories work?

During pregnancy, a woman often faces a dilemma: whether to take medication, even if recommended by a doctor, or still refrain from "chemistry".

However, pregnancy does not last one day or even a month. For a long nine months, drug therapy may be required, for example, in order to keep this very pregnancy and in order for the baby to feel comfortable in the womb until the very term of birth.

Therefore, if a medical prescription contains medication, then this should be treated with due attention. Taking such drugs is usually justified, and the safety has been confirmed by generations of our mothers and grandmothers.

Among the drugs prescribed to women during pregnancy, papaverine is often found.

Action and release form

Papaverine is the name of medicines containing the active ingredient papaverine hydrochloride.

The most popular use of papaverine is as an antispasmodic: a remedy that relieves muscle spasm, vascular and eliminates pain, as well as high blood pressure as a result of spasm.

The action of the drug is directed to the smooth muscles of the internal organs.

This means that you will not have to suffer from muscle weakness due to taking the drug, because. striated muscles are not affected by its action.

As a concomitant, when taking papaverine, a slight sedative effect is manifested.

Papaverine is produced in the form of tablets, ampoules for injection and rectal suppositories.

The most convenient to use, of course, tablets. They can be taken anytime and anywhere. Injections are made in a special way, without forcing the rate of entry of the drug into the blood, therefore, for this procedure it is better to visit a special room.

However, pregnant women are more often prescribed papaverine in suppositories in order to provide a milder effect on the body and not harm the child.

Moreover, the price of candles is quite acceptable and ranges from 85 rubles. for a blister of 10 pieces. Why are pregnant women prescribed candles with papaverine?

Indications for use

An official scientific study on the effects of papaverine on the body of a pregnant woman, the course of pregnancy and fetal development has not been conducted.

Therefore, in the instructions, the manufacturers of the drug do not take responsibility for unequivocally recommending or prohibiting the use of the drug during pregnancy or lactation.

Many years of medical experience in the use of suppositories with papaverine during pregnancy allows you to safely prescribe it to expectant mothers both in specific conditions characteristic of the period of bearing a baby, and with symptoms that are possible outside the gestation period.

Indications for the appointment of papaverine during pregnancy can be:

Increased tone of the uterus.

This is the most common reason for prescribing papaverine both as a single agent and as part of complex therapy. Papaverine suppositories with uterine tone are prescribed to relieve a strong tone of internal organs, including the uterus, and improve uterine blood flow.

Increased blood pressure.

The antispasmodic effect of the drug, affecting the walls of blood vessels, helps to lower blood pressure.

Pain, colic caused by spasms of internal organs (as part of complex therapy). Other situations requiring exposure to the body of antispasmodics and / or vasodilators.

The action of the drug, administered rectally, manifests itself very quickly, within a few minutes.

For any discomfort, the expectant mother should notify the doctor, who will monitor her condition and draw up a treatment plan, as well as determine the duration of taking suppositories with papaverine and dosage.

How to use suppositories with papaverine during pregnancy? As a rule, candles are prescribed in a course three times a day at regular intervals.

Candles with papaverine should be inserted into the anus, lying on its side.

It is advisable to do this after a bowel movement, so that there is no urge to empty the intestines.

Possible contraindications and side effects

The instructions for the use of suppositories with papaverine say that their use is contraindicated if the patient's medical history contains records of:

a heart rhythm disorder caused by a violation of AV conduction; increased intraocular pressure (glaucoma); hepatic, renal failure, in violation of the functions of the adrenal glands (with caution); violation of bronchial patency; inflammation of the rectum.

In addition, a woman's body during the period of bearing a child can react in an unexpected way even to a familiar and safe drug. Therefore, known or identified intolerance to the components of papaverine suppositories is also considered a contraindication to their use.

Negative manifestations from taking suppositories with papaverine are rare and are expressed in the form of itching, burning sensation of an allergic nature.

More serious consequences may occur due to exceeding the established dose: pronounced sedation, cardiac dysfunction, difficulty urinating and defecation, hypotension, dizziness, etc.

The use of suppositories with papaverine depending on the duration of pregnancy

As a rule, candles with papaverine or nosh-pa are not used separately.

Depending on the problem, antispasmodic drugs are usually prescribed in combination therapy with other drugs.

First trimester

In the first trimester of pregnancy, until the placental protection of the fetus has formed, the list of medicines that have no contraindications for use is very limited. This is the reason for the popularity of the appointment of papaverine suppositories as antispasmodics.

As a rule, at this time a woman suffers from toxicosis, so taking antispasmodic pills is not desirable.

Most often, pregnant women are prescribed papaverine suppositories with increased uterine tone and a possible threat of abortion.

So, unlike tablets, suppositories have a more prolonged effect, as they are absorbed more slowly. This means that a woman can experience a positive effect from candles throughout the day.

Perhaps the combined use of papaverine suppositories and no-shpy tablets in the treatment of uterine tone, the decision on this tactic is made by the doctor.

Often before the 16th week, the cause of uterine tone is insufficient production of the “pregnancy hormone - progesterone. Therefore, papaverine and other approved antispasmodics are prescribed in conjunction with hormone therapy.

Second trimester

In the second trimester, the list of approved drugs expands significantly.

Therefore, with a threat to the course of pregnancy, the state of health of the expectant mother and fetus, more serious drugs can be prescribed that inhibit the contractile activity of the uterus:

ginipral; bricanil; verapamil; nifedipine; injections and systems with magnesia.

Candles with papaverine are also used by pregnant women as a means of immediate response to abdominal pain, increased pressure, etc.

Such a measure allows you to maintain the mother's condition before contacting a doctor who will determine the need and duration of further papaverine intake as an antispasmodic.

third trimester

In the third trimester of pregnancy, there may be several reasons for prescribing suppositories with papaverine.

If the expected date of birth is still far away, then the indication for the introduction of suppositories with papaverine in late pregnancy becomes excessive tension of the uterus.

With the threat of premature birth, steroid hormones can be additionally prescribed.

When waiting for delivery in the near future, papaverine suppositories can be recommended as an indicator of "false" contractions.

If after their introduction the contractile activity of the uterus has stopped, then the term of labor has not yet come.

Candles with papaverine can be prescribed after the 38th week of pregnancy to soften the cervix. Antispasmodic suppositories are also prescribed at the beginning of labor to reduce pain during the first contractions.

It has now become fashionable to argue that pregnancy and childbirth are natural conditions for any woman, during which it is extremely undesirable to interfere.

However, many modern mothers forget that adherence to sleep and rest regimes, good nutrition, giving up bad habits, and the absence of excessive stress loads are also natural behavior that a woman whose purpose is motherhood should strive for.

In such circumstances, common sense suggests not to rely on chance during a crucial period, but to clearly follow all the instructions of a competent doctor in order to go through the entire nine-month pregnancy without loss, “laying straws in advance” where there is a risk of “falling”.

Papaverine (candles, tablets, injections) - instructions for use, analogues, reviews, price

Varieties, names, forms of release and composition of Papaverine preparations

All four drugs are synonymous and are available in three dosage forms - tablets for oral administration, rectal suppositories and solution for injection. Suppositories are often called "papaverine suppositories", and the solution is called "papaverine injections", "papaverine in ampoules" or "papaverine injections".

Tablets for adults - 40 mg;
Tablets for children - 10 mg;
Solution for injection - 20 mg per 1 ml;
Rectal suppositories - 20 mg per suppository.

The composition of auxiliary components for the same dosage form, for example, tablets, may vary depending on the manufacturer, so it should always be carefully read in the attached leaflet with instructions for use.

Therapeutic effects of papaverine

Relaxes smooth muscles and relieves spasms of smooth muscles of blood vessels, organs of the digestive, respiratory and genitourinary systems;
By relaxing the muscles of the blood vessels and their subsequent expansion, it lowers blood pressure;
High doses reduce the excitability of the heart muscle and slow down the conduction of the impulse through the heart;
In high dosages, it has a sedative effect on the central nervous system.

Thus, Papaverine has two main pharmacological effects - antispasmodic (stops spasm and relaxes smooth muscles) and hypotensive (lowers blood pressure).

Papaverine (tablets and injections) - indications for use

Spasms of smooth muscle elements of the gastrointestinal tract in various diseases, such as pylorospasm, colitis, cholecystitis, cholangitis, etc.;
Spasmodic pain (for example, with colitis, flatulence, menstruation, irritable bowel syndrome (IBS), constipation, etc.);
As part of the complex therapy of cholecystitis and renal colic as an anesthetic and anti-spasm drug;
Spasms and pains in the organs of the genitourinary system (cystitis, pyelitis, stones in the kidneys or in the urethra, etc.);
Bronchospasm;
Spasm of cerebral vessels;
Spasm of peripheral vessels, for example, with endarteritis and other diseases;
As part of the complex therapy of angina pectoris;
As an auxiliary preparation for pre-narcotic preparation (premedication).

Papaverine (papaverine hydrochloride) - instructions for use

Papaverine tablets - instructions for use

6 - 24 months - 5 mg (1/2 children's tablet) 3 - 4 times a day;
2 - 4 years - 5 - 10 mg (1/2 - 1 children's tablet) 3 - 4 times a day;
5 - 6 years - 10 mg (1 children's tablet) 3 - 4 times a day;
7 - years - 10 - 15 mg (1 - 1.5 children's tablets) 3 - 4 times a day;
10 - 14 years old - 15 - 20 mg (1.5 - 2 children's tablets) 3 - 4 times a day.

The duration of therapy depends on the rate of disappearance of spastic pain or relief of organ spasm. In acute conditions, Papaverine is usually taken for 2 to 5 days, and in chronic conditions, 1 to 3 weeks.

Papaverine in ampoules - instructions for the production of injections

6 - 24 months - 0.25 ml of solution 2 - 4 times a day;
2 - 4 years - 0.25 - 0.5 ml of solution;
5 - 6 years - 0.5 ml of solution;
7 - years - 0.5 - 0.75 ml of solution;
10 - 14 years - 0.75 - 1 ml of solution;
15 years and older - 1 - 2 ml of solution.

That is, in the indicated dosages, the solution is administered 2 times a day to children under 10 years of age, and 2 to 4 times a day to adolescents over 10 years of age and adults.

Papaverine - instructions for the use of candles

Dosage for various diseases

6 - 24 months - 5 mg;
2 - 4 years - 5 - 10 mg;
5 - 6 years - 10 mg;
7 - years - 10 - 15 mg;
10 - 14 years - 15 - 20 mg;
Over 14 years old - 20 - 60 mg.

At the same time, Papaverine in the indicated dosages is taken a different number of times a day, depending on the dosage form - tablets 3-4 times, the solution is administered 2-4 times a day, and suppositories - 2-3 times. Moreover, children under 6 years of age should use Papaverine the smallest of the allowable amounts once a day, and at the age of over 6 years, the frequency of taking the drug is determined by the state of the person, and can be maximum.

special instructions

Overdose

Interaction with other drugs

Use during pregnancy, including in the early stages

Instructions for use Papaverine (tablets, injections) during pregnancy

Candles with papaverine during pregnancy

Papaverine for children

6 – 24 months- 5 mg (1/2 children's tablet, 0.25 ml solution or 1/4 suppository) 2 times a day;
24 years- 5 - 10 mg (1/2 - 1 children's tablet, 0.25 - 0.5 ml of solution or 1/4 - 1/2 suppositories) 2 times a day;
5 – 6 years- 10 mg (1 children's tablet, 0.5 ml solution or half a suppository) 2 times a day;
7 - 9 years- 10 - 15 mg (1 - 1.5 children's tablets, 0.5 - 0.75 ml of solution or 1/2 - 2/3 suppositories) 2 - 3 times a day;
10 – 14 years old- 15 - 20 mg (1.5 - 2 children's tablets, 0.75 - 1 ml of solution, 2/3 - 1 suppository) 2 - 3 times a day;
Teenagers over 14- 20 - 40 mg (1 adult tablet, 1 - 2 ml of solution or 1 - 2 suppositories) 3 - 4 times a day.

Children should be given only special children's tablets of Papaverine, which contain 10 mg of the active substance, and not broken into small pieces by adults. When using the solution, small syringes should be taken in order to accurately measure the required amount of the drug. And when using candles, they must be cut into pieces along, not across. In young children, it is recommended to use Papaverine in suppositories or solution, since they still have difficulty swallowing tablets. In older age groups, any convenient dosage form can be used.

Papaverine for pressure

Side effects

Decreased blood pressure;
Extrasystole;
AV block;
Constipation;
Nausea;
sweating;
Yellowness of the skin and sclera of the eye;
Increased activity of transaminases (AST, ALT);
Drowsiness;
Eosinophilia (an increase in the number of eosinophils in the blood);
Thrombosis (only with intravenous administration);
Allergic reactions.

Contraindications for use

Hypersensitivity to drug components;
AV block;
Glaucoma;
Liver failure;
Elderly age over 65;
Children under 6 months of age.

In addition to these contraindications, there are a number of conditions in which Papaverine should not be used until recovery or complete rehabilitation. These conditions are temporary restrictions on the use of the drug, since after their cure or stabilization of the condition, Papaverine can be used with caution. So, the restrictions on the use of the solution, suppositories and tablets Papaverine are the following conditions:

14. Spazmonet and Spazmonet forte tablets;

15. Spazoverin tablets;

16. Spakovin solution for injections and tablets.

Reviews

Papaverine during pregnancy - reviews

Differences between Papaverine and other antispasmodics (No-Shpa, Duspatalin, etc.)

Dibazol with Papaverine (indications and dosage)

Analgin, Papaverine and Diphenhydramine (or Diphenhydramine and Papaverine, or Analgin and Papaverine)

Papaverine (tablets, suppositories and solution) - price

Tablets, 10 pieces - 5 - 22 rubles;
Tablets, 20 pieces - 38 - 56 rubles;
Ampoules of 2 ml, 10 pieces - 73 - 109 rubles;
Candles, 10 pieces - 45 - 97 rubles.

Indications for the use of Papaverine - when and for whom it is relevant

Papaverine is a drug that is widely used in modern medicine. Due to the fact that there are several forms of release, it can be prescribed by a specialist to people with varying degrees of susceptibility. Indications for the use of Papaverine are different, therefore, in hospitals, for example, injections are used, at home you can use tablets or suppositories.

Release form and composition

Papaverine belongs to the group of opioid alkaloids produced by synthesizing various components. Its main active ingredient is papaverine hydrochloride. The drug is available in three dosage forms:

Tablets. Produced in blisters of 10 pieces. Each tablet contains 40 mg of the active ingredient, in the preparation for children its share is less and is only 10 mg.
Injection. Available as 2 ml ampoules, each contains the same amount of active ingredient as the tablets. Packed in cardboard boxes of 5 and 10 pieces (together with a special ampoule knife).
Rectal suppositories. Candles contain 20 mg of papaverine hydrochloride and are intended for injection into the rectum. They are packed in special packs of 5 pieces each.

Pharmacological action of the drug

The drug is able to save a person from spasms of the smooth muscles of the intestines, stomach and other organs of the digestive system, bronchi, uterus, kidneys, bladder and gallbladder. When exposed to the components of the drug, there is an exceptionally relaxing effect, elasticity and proper movements of all muscle groups are preserved in full.

What helps papaverine

As mentioned earlier, Papaverine is an antispasmodic, which also has a hypotensive and anticonvulsant effect. What is papaverine used for?

providing a sedative effect when prescribed by a specialist in large doses;
vasodilation;
decreased tone of smooth muscles of the genitourinary and respiratory systems, as well as the heart;
improved blood flow.

After entering the body, the drug begins to be absorbed almost immediately, the maximum effect of Papaverine is achieved within half an hour. Excreted from the body through the kidneys.

Recommendation: if there is an urgent need to remove all components of the drug from the body, then you can resort to dialysis. During this procedure, the blood is completely cleansed of toxins, as well as unnecessary and harmful substances.

When is Papaverine prescribed?

The main indications for the use of Papaverine are muscle spasms that occur in the following cases:

endarteritis is a disease in which the lumen in the arteries is completely blocked, which entails a violation of blood flow. Along with this, damage to internal organs begins and gangrene develops. For the most part, this ailment affects the vessels located in the lower extremities;
inflammation of the bronchi, in which bronchospasm is by no means a rare occurrence;
diseases of the abdominal organs - colitis, cholecystitis, renal colic;
angina, in which certain parts of the heart stop receiving blood in the right amount. The disease is characterized by blockage or narrowing of blood vessels, as a result of which severe chest pains develop against this background;
problems associated with vessels located in the brain;
with exacerbation of attacks of gallstone disease.

Papaverine can also be used for surgical intervention. It is administered by an anesthetist to reduce the tone of the airway muscles. Thanks to this organism, the patient will be much easier to endure anesthesia.

Is it possible to take papaverine during pregnancy

The vast majority of women in position are faced with such a phenomenon as uterine hypertonicity. This condition is considered quite dangerous because it can provoke premature birth. Even during seizures, blood flow to the fetus decreases, which entails negative consequences - the child simply does not receive all the necessary nutrients and substances. To reduce muscle tone, women are prescribed Papaverine, which can also lower blood pressure if it suddenly rises. Along with this, there is an improvement in blood flow to the uterus, which positively affects the development of the child.

Another positive property of Papaverine is that it has a sedative effect. It relieves nervous tension, which is characteristic of many pregnant women, namely, it is known that it can provoke the development of uterine tone.

Important: take the antispasmodic Papaverine during pregnancy should be cautious, at the slightest suspicion of a deterioration in the condition, you should stop taking it and consult a doctor.

A number of side effects are possible:

an allergic reaction is rare, but possible. Most often, women are concerned about itching on the skin and urticaria;
dizziness;
drowsiness;
constipation;
when administered intravenously, cardiac arrhythmias may occur.

A completely logical question that arises in many women is where, in fact, to insert suppositories (if such a dosage form was prescribed), if they are intended for rectal administration, and it is necessary to have a therapeutic effect in the genitourinary system? The answer is simple - where it is shown, since the active ingredients are quickly absorbed into the bloodstream and are first distributed locally to nearby organs, and then further throughout the body. This contributes to the fact that the smooth muscles of the uterus will be saturated with the substances of the drug in full and in a short time.

Contraindications - to whom and when Papaverine is prohibited

In order to avoid the appearance and development of allergic reactions, you should not take Papaverine if there is an individual intolerance to the active substance or other components of the drug. Treatment with the drug should be interrupted immediately if signs of allergy are found. The instruction to the medicine says that the contraindications to Papaverine are as follows, and it is forbidden to take it:

small children (up to 6 months);
To old people;
those who have arterial hypotension (low blood pressure);
patients with glaucoma;
people with renal insufficiency (the kidneys simply will not be able to fully remove the components of the drug from the body);
hospital patients in a coma.

With extreme caution, Papaverine should be taken by those who are diagnosed with:

traumatic brain injury;
hypothyroidism;
prostatic hyperplasia;
state of shock;
supraventricular tachycardia;
adrenal dysfunction.

Side effects

The cardiovascular system

It is possible to develop atrioventricular blockade - a condition in which the electrical impulse between the ventricles and the atria slows down or stops altogether. This leads to a heart rhythm disorder. Along with this, a decrease in blood pressure and ventricular tachycardia are possible.

Gastrointestinal tract

bloating;
nausea and vomiting;
dysfunction of the passage of food through the intestines.

All other side effects of Papaverine include allergic reactions, excessive drowsiness and eosinophilia - an increase in the blood level of special cells responsible for fighting toxins and various microorganisms.

It should be remembered that by themselves side effects develop extremely rarely. They can appear only in those cases when a person independently and without consulting a specialist began taking Papaverine or when he significantly exceeded the dosage recommended by the doctor.

The information in the article is for informational purposes, self-medication is not recommended. Only a doctor should prescribe Papaverine and select the dosage.