Sulfocamphocaine action. Sulfocamphocaine for cats. Instructions for use
Sulfocamphoric acid
Composition and form of release of the drug
Excipients: procaine 100.8 mg/2 ml.
2 ml - ampoules (10) - cardboard boxes.
2 ml - ampoules (10) - contour plastic packaging (1) - cardboard boxes.
2 ml - ampoules (10) - contour plastic packaging (34) - cardboard boxes.
2 ml - ampoules (10) - contour plastic packaging (36) - cardboard boxes.
2 ml - ampoules (150) - cardboard boxes.
2 ml - ampoules (200) - cardboard boxes.
2 ml - ampoules (5) - contour plastic packaging (1) - cardboard boxes.
2 ml - ampoules (5) - contour plastic packaging (2) - cardboard boxes.
2 ml - ampoules (5) - contour plastic packaging (34) - cardboard boxes.
2 ml - ampoules (5) - contour plastic packaging (36) - cardboard boxes.
pharmachologic effect
Combined drug, has an analeptic effect. Stimulates the respiratory and vasomotor centers. It has a direct effect on the myocardium, enhancing metabolic processes and increasing its sensitivity to sympathetic impulses. Increases the tone of peripheral blood vessels. Improves lung ventilation, pulmonary blood flow. Increases the secretion of bronchial glands.
Indications
Contraindications
- hypersensitivity.
FROM caution: arterial hypotension, pregnancy, lactation.
Dosage
P / c, in / m, in / in (jet or drip), 2 ml of a 10% solution, 2-3 times / day. The maximum daily dose is 12 ml of a 10% solution.
Name:
Sulfocamphocaine (Sidfocamphocainum)
Pharmacological
action:
Combined drug, has an analeptic effect.
The active components of Sulfocamphocaine have an analeptic effect.
The effect of the use of Sulfocamphocaine according to the instructions is due to the camphor and novocaine that are part of the drug.
A distinctive feature from other drugs with a similar effect is the rapid absorption when administered subcutaneously, as well as the high safety of the drug.
As a result of the use of Sulfocamphocaine:
- the tone of peripheral blood vessels increases;
- metabolic processes are intensified (due to a direct effect on the myocardium);
- improves ventilation of the lungs and pulmonary blood flow;
- increases the sensitivity of the myocardium to sympathetic impulses;
- production of secretion of bronchial glands increases.
Indications for
application:
According to the instructions, Sulfocamphocaine is prescribed for:
- acute and chronic heart failure;
- cardiogenic shock;
- acute cardiopulmonary insufficiency;
- hypotension;
- collapse;
- anaphylactic shock.
In addition, according to the instructions, Sulfocamphocaine is used for circulatory disorders caused by infectious diseases.
So, the drug is indicated for the prevention and treatment:
- pneumonia;
- purulent pleurisy;
- narcotic and drug poisoning.
Mode of application:
Most often Sulfocamphocaine is administered subcutaneously.
In some cases, according to indications, the drug can be administered intramuscularly and intravenously(both jet and drip).
The standard dosage is 2 ml of a 10% solution of Sulfocamphocaine, two to three times a day. A maximum of 12 ml of solution can be administered per day.
In most cases, the duration of the use of Sulfocamphocaine according to reviews is set individually.
In the treatment of chronic heart and respiratory failure, the drug is administered for 20-30 days (subcutaneously or intramuscularly).
Side effects:
Sulfocamphocaine, according to reviews, can cause a sharp decrease in pressure, which is most often observed with existing hypotension.
In addition, with a predisposition, Sulfocamphocaine can lead to the development of allergic skin reactions in the form of itching and redness (at the injection site).
Contraindications:
Hypersensitivity.
Carefully: arterial hypotension, pregnancy, lactation.
Interaction
other medicinal
by other means:
Sulfocamphocaine according to the instructions can be used simultaneously with steroid hormones, cardiac glycosides and analgesics.
Pregnancy:
Carefully: pregnancy, lactation.
Overdose:
Symptoms: in case of an overdose, the following are possible: headache, dizziness, in case of acute poisoning - redness of the face, restlessness, delirium, epileptiform convulsions.
Treatment: in case of overdose, depending on the underlying syndrome, antipsychotic and anticonvulsant drugs are prescribed. With unexpressed psychomotor agitation - tranquilizers or sedatives.
Some facts about the product:
Instructions for use
Price in the online pharmacy site: from 130
Some facts
Sulfocamphocaine for injection is a 10% combined analeptic drug that has an exciting effect on the cardiovascular and respiratory systems by increasing their sensitivity. Stimulates the functioning of vital organs, in particular the lungs and myocardium. Used in otolaryngology and cardiology for reduced vascular tone, heart failure, respiratory depression, etc.
The analeptic was developed by the Russian pharmaceutical company Pharmstandard-UfaVITA. It contains sulfocamphoric acid + procaine, which have cardiotonic activity. Influencing the work of the medulla oblongata, the drug enhances metabolic processes in the myocardial tissue, and also stimulates the functions of the vasomotor and respiratory centers. In this regard, Sulfocamphocaine for injection 10% is widely used in medical practice to support the life of patients with heart failure, cardiogenic shock and respiratory depression.
Release form
Analeptic is a clear solution for parenteral administration. It consists of two active components: sulfocamphoric acid and procaine. Produced in glass ampoules with a capacity of 2 ml, each containing 200 mg of active ingredients. There are 10 ampoules in a cardboard box along with instructions for using the analeptic.
Pharmacological properties
The pharmacological activity of the drug is due to the strong excitation of the central nervous system through the carotid sinus. Stimulation of the centers located in the bulb of the brain leads to an increase in the tone of the organs of the respiratory and cardiovascular systems. By increasing the sensitivity of sympathetic nerves, metabolic processes in the myocardial tissue are accelerated.
According to practical data, Sulfocamphocaine for injections 10% improves blood circulation in the vascular network of the peritoneal organs, stimulates blood flow to the myocardium, increases the tone of the venous vessels and normalizes the blood supply to the lungs and brain tissue. The cardiotonic properties of the drug are due to the intensification of the respiratory processes, as well as its adrenosensitizing activity.
Pharmacokinetic properties
The analeptic drug is rapidly absorbed when administered parenterally. Sulfocamphoric acid + procaine quickly undergo oxidative processes. The decay products are excreted mainly by the kidneys, while the urine acquires a characteristic smell of a medicinal solution. A small part of the metabolites are excreted with bile and carbon dioxide during respiration.
Indications for use
The drug is used as a respiratory and cardiogenic stimulant in violation of the functions of vital organs. Indications for the appointment of an analeptic are:
- left ventricular failure;
- abnormal breathing;
- heart failure against the background of poisoning;
- tachypnea;
- anaphylactic shock;
- respiratory depression;
- respiratory disorders of central origin;
- critical decrease in vascular tone.
Sulfocamphocaine for injection 10% is widely used in the treatment of infectious diseases, accompanied by dysfunction of the respiratory and cardiovascular systems. As a stimulant, it is recommended in the postoperative period for the speedy recovery of patients.
Dosing regimen
The medicinal solution is applied intravenously (drops, jet), subcutaneously or intramuscularly. The dosage depends on the age and general well-being of the patient. The optimal single dose for adults is 2 ml. During the day, you can enter no more than 12 ml of the drug, because. it can have a toxic effect on the functioning of the kidneys.
In the case of drip administration, it is recommended to dilute Sulfocamphocaine for injection 10% with isotonic sodium chloride solution. In acute heart failure, the drug is administered intravenously, in the chronic course of the disease, subcutaneously or intramuscularly. The duration of the course of treatment ranges from 20 to 30 days.
Application features
Procaine has pronounced hypotensive properties, so the solution should be used with caution in the treatment of patients with arterial hypotension. Also, the drug can affect the rate of reactions, so it is advisable to refrain from driving vehicles for the duration of the course.
Interaction with medicines
With the parallel use of other medicines, it is possible:
- with analgesics and diuretics, potentiation of analeptic activity;
- with MAO inhibitors, a critical increase in blood pressure (hypertensive crisis);
- anticholinesterase medications reduce the pharmacological activity of the latter;
- with steroid hormones, increased stimulating effect of sulfocamphoric acid;
- with drugs that depress the central nervous system, a decrease in the pharmacological activity of the latter.
Pregnancy and lactation
Evidence-based medicine does not have data on the safety of Sulfocamphocaine 10% Injection during pregnancy. Therefore, during the period of gestation and breastfeeding, an analeptic is not prescribed.
Alcohol compatibility
Alcohol stimulates an increase in blood pressure and, as a result, enhances the cardiotonic activity of sulfocamphoric acid. To prevent hypertension, you need to stop drinking alcohol during the course of treatment.
Overdose
Exceeding the daily dosage (more than 12.0 ml) is fraught with the development of severe adverse reactions, which include:
- severe headaches;
- spatial disorientation;
- flushing of the skin of the face;
- hallucinations;
- abnormal motor activity;
- rapid shallow breathing;
- epileptiform convulsions.
With moderate severity of psychomotor agitation, sedative medications and tranquilizers should be taken. To eliminate hallucinations and seizures, it is recommended to use anticonvulsant drugs and antipsychotics.
Side effects
During the use of Sulfocamphocaine for injection 10%, patients may experience the following adverse reactions:
- increase or decrease in blood pressure;
- headache;
- hives;
- hyperemia of the face;
- angioedema;
- paresthesia;
- skin rashes;
- feverish state;
- frequent urination;
- methemoglobinemia;
- tremor in the hands;
- dyspeptic phenomena;
- convulsions;
- anaphylactic shock;
- skin itching.
If side effects occur, discontinue therapy and consult a doctor. Delayed medical care can lead to death.
Contraindications
- epilepsy;
- pregnancy and lactation;
- age up to 18 years;
- uncontrolled arterial hypertension;
- acute renal failure;
- impaired glomerular filtration.
With the course use of the drug, patients with kidney dysfunction need to control the concentration of creatinine in the systemic circulation and the breakdown products of the analeptic. An increase in the level of active substances in the solution in the body is fraught with the development of severe systemic reactions.
Analogues
Sulfocamphocaine for injection 10% can be replaced with drugs that have a stimulating effect on the respiratory and vasomotor centers in the bulb of the brain. Analogues of the analeptic according to the pharmacological group include:
- Corazol;
- Securinine nitrate;
- Sulfocaine;
- Instenon;
- Sulfoprocaine;
- Armanor;
- Etimizol;
- Niketamide;
- Bemegrid;
- Lobelin;
- Cordiamin.
It is not recommended to use the above medicines without the approval of a doctor. An overdose of analeptics can lead to irreversible consequences and even death.
Terms of storage and sale
The medicinal solution is sold in pharmacies only with a written prescription from a doctor. It is stored in a place protected from light at a temperature of 5-30 degrees Celsius for 36 months.
Sulfocamphocaine is a combined drug with an analeptic effect. Its action is explained by the ability to excite the central nervous system.
First of all, Sulfocamphocaine acts on the nerve centers of the medulla oblongata directly or through the carotid sinus.
Its use helps to tone the respiratory and vasomotor center, as well as enhance metabolic processes in the myocardium and increase its sensitivity to sympathetic nerve impulses.
Due to the direct influence of Sulfocamphocaine on the walls of blood vessels, redistribution of blood occurs and the tone of venous vessels increases.
This drug helps to narrow the lumen of the vessels of the organs in the abdomen, increase blood flow to the heart, as well as improve coronary blood flow and blood circulation in the lungs and brain. It also improves lung ventilation and increases the production of bronchial gland secretions.
Sulfocamphocaine is characterized by rapid absorption even in the case of subcutaneous administration and has a high degree of safety.
Once in the body, the drug goes through the process of oxidation and conjugation with glucuronic acid. The drug is excreted mostly with the help of the kidneys, which is why the patient's urine acquires a specific smell.
The cardiotonic effect of this drug is due to its adrenosensitizing effect on the body, as well as the intensification of the processes of respiration and glycolysis, which are associated with the phosphorylation of macroergic compounds.
Indications for use
Sulfocamphocaine is used in the following cases:
- Respiratory failure of chronic and acute type.
- Anaphylactic and cardiogenic shock.
- Heart failure in acute and chronic form.
- Respiratory depression caused by pneumonia, pleurisy and other infectious diseases.
Breathing problems due to poisoning with morphine, sleeping pills and drugs, as well as alcohol.
For the elderly, Sulfocamphocaine is often prescribed after an injury such as a hip fracture to prevent congestion in the lungs, maintain the circulatory system and heart.
Sulfocamphocaine is widely used in veterinary practice, as its use contributes to the stimulation and support of the cardiovascular system of animals. Most often it is prescribed to dogs and cats for injuries and liver diseases.
Release form, composition
The described drug is available in the form of a solution for injection, which is a clear, colorless or slightly yellowish liquid. This liquid is poured into glass ampoules with a capacity of 2 milliliters, which are sold in cartons of ten.
One milliliter of this medicine contains:
- 49.6 milligrams of sulfocamphoric acid, calculated as anhydrous;
- 50.4 milligrams of novocaine base, that is, procaine. This is an analgesic substance with moderate activity;
- injection water.
To purchase Sulfocamphocaine in a pharmacy for a patient you need a prescription.
Mode of application
Sulfocamphocaine can be used for subcutaneous, intravenous and intramuscular administration. The dose of the drug, the method of its administration and the duration of the treatment course are set individually by doctors, but the standard dose of Sulfocamphocaine is 2 milliliters of a 10% solution, which must be administered two or three times a day.
The maximum daily dose is 12 milliliters of the described medicine. Sulfocamphocaine can be administered intravenously only in the most extreme cases, when it is necessary to stop an acute attack of the disease.
In this case, 2 milliliters of a 10% solution of this drug is administered by stream or drip.
In chronic respiratory or heart failure, Sulfocamphocaine is applied subcutaneously or intramuscularly for twenty to thirty days.
Interaction with other drugs
Sulfocamphocaine reduces the inhibitory effect on breathing of sleeping pills, morphine, narcotic painkillers, alcohol, as well as anesthetics that they have in case of overdose.
Sulfocamphocaine can be safely combined with cardiac glycosides and diuretic drugs. This drug can also reduce unwanted side effects that occur during chemotherapy with 5-fluorouracil.
The use of alcoholic beverages during treatment with the described medication is strictly unacceptable.
The analeptic effect of Sulfocamphocaine is enhanced with the simultaneous use of steroid hormones, cardiac glycosides and analgesics.
Side effects
When using Sulfocamphocaine, the following side effects may occur:
- Allergic manifestations in the form of itching, rashes and redness that occur at the injection site.
- Decreased blood pressure.
- Dyspepsia.
When such signs appear, the patient may be prescribed anticonvulsant and antipsychotic drugs.
Persons with unexpressed psychomotor agitation are prescribed sedatives and tranquilizers.
Contraindications
The described drug is not allowed to be used in the presence of the following circumstances:
- Hypersensitivity to camphor, novocaine and excipients
- Epilepsy
- Tendency to have seizures
- Children's age up to eighteen years
- Period of gestation and lactation
Patients with arterial hypotension should be especially careful when using Sulcamphocaine.
Before its introduction, it is imperative to measure the pressure, and if it is very low, the use of the drug should be avoided.
During pregnancy
Since there are currently no objective data on the possibility of using Sulfocamphocaine in women who are expecting a baby, this medicine is usually not prescribed to such patients.
Terms and conditions of storage
Sulfocamphocaine should be stored at an air temperature of 8 to 25 degrees Celsius. The drug should be placed in a place securely protected from direct sunlight and inaccessible to small children.
Its shelf life is three years.
Price
Approximate cost of the described drug in Russian pharmacies is at the level of 160 rubles.
Inhabitants of Ukraine currently they can buy Sulfocamphocaine for about 70 hryvnias.
Analogues
Sulfocamphocaine has several analogues, among which it is worth highlighting:
- Sulfocaine;
- Sulfoprocaine;
- Ammonia;
- Armanor;
- Etimizol;
- Niketamid-Eskom;
- Securinine nitrate.
Diseases of the cardiovascular system in the modern world are extremely common. Fortunately, modern pharmacology can offer a wide range of remedies to help manage symptoms and reduce the risk of developing life-threatening conditions. One such remedy is Sulfocamphocaine.
This is a common remedy designed to combat pathologies of the cardiovascular system associated with heart failure. This article will describe in detail the pharmacological properties of the drug, its effectiveness, rules of use and currently existing analogues.
To begin with, you should talk about what Sulfocamphocaine is. Namely, to designate the basic characteristics of the drug.
Drug group and scope
Sulfocamphocaine belongs to the group of analeptics - drugs that have a stimulating effect on the nervous system, respiratory and vascular centers of the brain. These drugs are designed to increase the tone of blood vessels and the cardiovascular system. Their main function is to stimulate the corresponding centers of the brain. The international non-proprietary name of the drug is Sulfocamphoric acid / procaine.
Release form
The drug has only one form of release - a solution for injection. The liquid either has no color, or is characterized by a barely noticeable yellowish tint. The drug is available in ampoules of two milliliters, each package contains ten such ampoules. The drug is not available in the form of tablets. Below are the average prices for one package by regions of Russia (Table 1).
Table 1 - The average cost of Sulfocamphocaine in the regions of the Russian Federation
| Region | Price in rub. |
|---|---|
| Moscow and region | 130 |
| St. Petersburg and Leningrad region | 140 |
| Yaroslavl region | 176 |
| Chelyabinsk region | 174 |
| Khanty-Mansi Autonomous Okrug | 175 |
| Ulyanovsk region | 142 |
| Tyumen region | 163 |
| Tomsk region | 162 |
| Tatarstan | 183 |
| Stavropol region | 190 |
| Sverdlovsk region | 142 |
| Saratov region | 164 |
| Rostov region | 167 |
| Primorsky Krai | 188 |
| Murmansk region | 210 |
| Komi | 184 |
| Vologodskaya Oblast | 176 |
| Vladimir region | 200 |
| Altai region | 181 |
The table shows average prices. They may vary depending on the pricing policy of a particular pharmacy.
Chemical composition
The active substance is sulphocamphoric acid. One ampoule contains approximately 50 ml of this substance. The auxiliary component is the anesthetic novocaine, also known as procaine. The ampoule also contains approximately 50 ml. Apart from these two compounds, only water for injection is present.
The stimulant properties of the combination of sulphocamphoric acid and procaine are widely used to relieve symptoms of heart and vascular insufficiency. In addition, the drug is used for emergency treatment of shock conditions associated with allergic or cardiovascular disorders.
Is it an antibiotic or not?
It is often misunderstood that Sulfocamphocaine is an antibiotic. However, this is not the case, the drug does not have an antimicrobial effect. This misconception arose due to the fact that the drug is often prescribed for inflammatory pathologies of the lungs of a bacterial nature as part of complex therapy.
However, Sulfocamphocaine is not aimed at fighting bacteria, but at improving gas exchange and microcirculation in the lungs, and it also tones the respiratory centers of the brain.
This allows you to take it in severe conditions caused by bacterial damage to the respiratory system as a symptomatic therapy.
Pharmacodynamics and pharmacokinetics
The pharmacological action of the drug can be characterized as follows:
The combined drug is rapidly absorbed due to the high degree of solubility in water. Excretion of procaine and sulphocamphoric acid occurs mainly through the liver. Some of the decay products are excreted through the respiratory tract.
Indications and contraindications
Sulfocamphocaine, like any other drug, has its indications and contraindications. This information is given in the table below (Table 2).
Table 2 - Indications and restrictions for taking Sulfocamphocaine
Treatment with this drug should be strictly under the supervision of a physician, who makes an appropriate decision based on the general health of the patient and the individual characteristics of his body.
Instructions for use
The order of use of the remedy is determined only by the attending doctor in accordance with the patient's diagnosis. However, there are several general nuances and recommendations that relate to the dosage and compatibility of the drug with other drugs.
Dosage regimen and reception nuances
The drug is administered intramuscularly, under the skin and into the veins. The latter is permissible only in emergency cases. Intravenous administration is carried out only in a hospital with the help of specialized medical equipment.
A single dose of the drug is an average of two milliliters. The number of daily sessions of administration is determined by the doctor. Usually this is two or three times a day.
The introduction of more than 12 milligrams of the substance during the day is strictly contraindicated in order to avoid side effects.
The timing of therapy is determined individually depending on the specifics of the diagnosis. For patients with chronic heart or respiratory failure, it lasts from 20 days to a month.
Compatibility with other drugs
There is no data on the complete incompatibility of the drug with other drugs. When conducting complex therapy, it is necessary to take into account the following features:
Side effects and precautions
The main side effect that may occur during the therapeutic course is a decrease in blood pressure to dangerous levels. The category of patients that is initially susceptible to hypotension is especially susceptible to this risk.
Therefore, the course of admission should be accompanied by constant monitoring of blood pressure both by the patient himself and by the doctor. With a steady decrease in blood pressure to pathological levels, the course should be stopped immediately.
In addition, the drug can cause problems with the gastrointestinal tract, expressed in the difficulty of the digestion process. Another possible adverse reaction is associated with individual intolerance to the components of the agent. At the first sign of an allergic reaction, the course should be discontinued.
Analogues
This drug has a number of analogues. They can be divided into two groups: these are either products based on the same active ingredient, or products with a similar effect, but with a different chemical composition and belonging to a different pharmacogroup.
Structural
Modern pharmacology can offer two structural analogues of this drug. They are based on the same active substance:
- Sulfocaine.
- Sulfoprocaine.
They are absolutely similar in chemical formula and mechanism of action. All other characteristics are also the same. Both analogues have only one big comparative drawback - they are much harder to buy, they are practically absent in pharmacies. The cost of one pack varies from 80 to 150 rubles, depending on the region and the pricing policy of a particular pharmacy.
Drugs with a similar effect
There are also a number of drugs whose action is similar to that of Sulfocamphocaine, but which are based on other active substances. They are presented in the table below (Table 3).
Table 3 - Drugs of other groups, similar to Sulfocamphocaine in action
| Name | Active substance | Advantages | Flaws | Average price in rubles |
|---|---|---|---|---|
| Hydroxymethyl-ethylpyridine succinate | A wider range of indications can be taken without direct medical supervision. | A wider list of contraindications and side effects. The main disadvantage is that it is not recommended for the treatment of persons under 18 years of age. | 140 | |
| Trimetazidine hydrochloride | Does not affect the central nervous system. | Wider range of possible side effects. | 130 | |
| Hawthorn fruits infused with ethanol | Low price, does not require a medical prescription. | Low efficiency in the late stages of cardiovascular disease. | 15 | |
| Meldonium (mildronate) | Low toxicity and high rate of excretion from the body. | Relatively large number of possible side effects. | 130 | |
| Phosphocreatine | High efficiency, a small number of contraindications and possible adverse reactions. | High price. | 4500 | |
| Low probability of an allergic reaction, relatively small list of contraindications, availability. | May provoke malfunctions in the work of the cardiovascular system when taken together with other similar drugs | 20 | ||
| Meldonium | Same as Meldonium. | Same as Meldonium. | 215 | |
| Vasonat | Meldonium | Same as Meldonium. | Same as Meldonium. | 150 |
The listed drugs are not full analogues of Sulfocamphocaine, and most of them cannot fully replace it, although they have a similar effect on the functioning of the myocardium and cerebral vessels. It is not recommended to take funds without the appropriate recommendations of the attending physician.