Veroshpiron contraindications for use. Veroshpiron capsules - instructions for use. Pharmacological properties of Veroshpiron

Veroshpiron is a potassium-sparing diuretic, a diuretic used against edema. The active ingredient is spironolactone.

It is prescribed for edema in heart failure, hypokalemia, hypomangiemia, and other conditions of the body accompanied by edema.

According to the instructions, the drug is a competitive antagonist of the mineralocorticoid aldosterone, a special hormone that is produced by the adrenal cortex. Spironolactone has an effect that is opposite to that of the hormone aldosterone.

Veroshpiron produces a pronounced diuretic effect, while it does not significantly affect the renal circulation and the functioning of the renal tubules, does not disturb the acid-base state in the body.

Due to the diuretic effect, which occurs 2-5 days after the start of use, the hypotensive (lowering blood pressure) effect of the drug is also achieved.

The active substance of the tablets is metabolized mainly in the liver cells (hepatocytes) with the formation of active intermediates, which are excreted from the body with the urine by the kidneys and in a small amount with the feces.

The half-life (the time after which half of the entire dose of the drug taken is excreted) is 12.5 hours. The half-life increases with cirrhosis of the liver (replacement of hepatocytes with fibrous connective tissue) and heart failure, while the active substance Veroshpiron is retained in the blood and body tissues.

Produced in the form of tablets of 0.025 g of active ingredient each. In 1 pack of 20 and 100 tablets.

Indications for use

What helps Veroshpiron? The drug is prescribed in the following cases:

• with edema associated with heart disease (chronic heart failure), endocrine system (Conn's disease, polycystic ovaries, hirsutism);
• with arterial hypertension;
• with ascites associated with cirrhosis of the liver;
• with cerebral edema and other diseases that are accompanied by edema;
• with severe burns;
• with paroxysmal paralysis associated with calcium deficiency;
• with myasthenia gravis (as a remedy for auxiliary treatment).

In gynecology, it is prescribed to reduce androgen levels in women with PCOS (polycystic ovary syndrome). The drug can cause bleeding, disrupt the menstrual cycle. Veroshpiron is often recommended to be taken in conjunction with contraceptives in order to normalize the menstrual cycle, reduce hirsutism.

Instructions for use Veroshpiron, dosage

Tablets are taken orally as a whole, preferably in the morning, after taking them, they are washed down with a sufficient amount of liquid. Adult patients are prescribed in the following dosage:

• With nephrotic syndrome, the daily dose is from 100 to 200 mg.
• With edematous syndrome, take from 100 mg / day. up to 200 mg / day. three times a day.

The drug is prescribed daily for 5 days, then the daily dose is gradually reduced and adjusted to 1 tablet of Veroshpiron 25 mg or increased to 400 mg in 4 divided doses.

• With high blood pressure, 50-100 mg of the drug is prescribed per day, once, or in 4 doses, for 2 weeks. The drug can be combined with antihypertensive drugs.
• With hypokalemia, take 25-100 mg at a time or up to 400 mg in several doses.
• In primary hyperaldosteronism, 100, 200 or 400 mg per day are prescribed in 4 doses before surgery and 25-50 mg for long-term treatment.
• With polycystic ovary syndrome and hirsutism, the use is reduced to 100 mg of the drug twice a day.

Children are prescribed 1-3.3 mg per kg of weight, and this amount is taken either fractionally (4 doses) or once. After 4 days of treatment, the dose is adjusted, while it is possible to increase it three times.

According to the instructions, when a clinical effect is achieved, the dosage is reduced to 1 tablet of Veroshpiron 25 mg per day, after which 1 tablet is taken 4 times a day / every 4 days.

Tablets are also used during various diagnostic tests aimed at determining the functional activity of the kidneys and the level of aldosterone in the blood. In these cases, the drug is taken as a single dose of 100-200 mg.

Side effects

According to the instructions for use, the appointment of Veroshpiron may be accompanied by the following side effects:

• dyspeptic disorders, pain in the abdominal region;
• sleep disturbances, lethargy, dizziness;
• changes in laboratory tests of blood and other body fluids;
• endocrine disruptions (in women - coarsening of the voice, metrorrhagia, amenorrhea or dysmenorrhea, in men - gynecomastia, as well as a decrease in libido and potency);
• muscle spasms.

All side effects are reversible and disappear after discontinuation of the drug, so if they develop, you should stop taking the tablets and consult a doctor.

Contraindications

It is contraindicated to prescribe Veroshpiron in the following cases:

• hyperkalemia and hypernatremia;
• severe form of renal failure;
• pregnancy and lactation;
• intolerance to the components of the drug, including lactose;
• Addison's disease.

Overdose

Overdose symptoms are nausea, vomiting, dizziness, decreased blood pressure, diarrhea, skin rash, hyperkalemia (paresthesia, muscle weakness, arrhythmias), hyponatremia (dry mouth, thirst, drowsiness), hypercalcemia, dehydration, increased urea concentration.

Treatment is gastric lavage, symptomatic treatment of dehydration and arterial hypotension.

In case of hyperkalemia, it is important to normalize the water-electrolyte metabolism with the help of potassium-releasing diuretics, rapid parenteral administration of a dextrose solution (5-20% solutions) with insulin at the rate of 0.25-0.5 IU per 1 g of dextrose. In severe cases, hemodialysis is performed.

Analogues Veroshpiron, price in pharmacies

If necessary, you can replace Veroshpiron with an analogue according to the ATC code - these are drugs:

1. aldactone,
2. Veroshpilakton,
3. spirix,
4. Renial,
5. epitor,
6. Spironol
7. Spironolactone,
8. Uracton.

When choosing analogues, it is important to understand that the instructions for use of Veroshpiron, the price and reviews of drugs of similar action do not apply. It is important to consult a doctor and not to make an independent replacement of the drug.

Price in Russian pharmacies: Veroshpiron 25 mg tablets 20 pcs. - from 74 to 90 rubles, 50 mg 30 pcs. - from 179 to 193 rubles.

Keep out of the reach of children at temperatures up to 30 degrees Celsius. Leave in pharmacies by prescription.

Many diuretic drugs provoke the development of an undesirable reaction - the appearance of hypokalemia. Such a violation leads to complications and negative effects on the part of the whole organism.

Therefore, many specialists try to prescribe potassium-sparing diuretics to their patients, and Veroshpiron is the most popular of them. This remedy not only removes excess fluid from the body, but also reduces pressure and makes patients with heart disease feel better.

Veroshpiron was created in the middle of the last century and is still very popular, because, compared with other diuretic drugs, it has a minimal effect on the water and electrolyte balance.

medicinal group

Veroshpiron is the trade name of a drug belonging to the pharmacological group of potassium-sparing diuretics. Throughout the world, this drug is known by its International Nonproprietary Name - Spironolactone.

Preparations based on spironolactone and produced under various trade names are actively used in almost all countries of the world to reduce pressure and rid the patient of excess fluid in the body.

The drug in medicine is mainly used to lower blood pressure and eliminate edema in heart failure. Also, its use is necessary for potassium deficiency caused by taking medications. It is especially popular with bodybuilders - professional athletes take the drug to reduce weight before competitions and improve muscle relief.

Forms of release and cost

Veroshpiron can be found at any pharmacy and purchased at a very low price. The drug is available in two forms and three dosages, the average cost of which can be seen in the table (Table 1).

Table 1 - Cost

The drug under the trade name Veroshpiron is produced only by the Hungarian company GEDEON RICHTER. But based on spironolactone, other drugs with a similar effect are also produced.

Compound

The active component of Veroshpiron, which affects the properties of the drug - spironolactone - is a substance that acts similarly to aldosterone, but leads to the opposite result.

Other components of the drug have an auxiliary effect. In addition to spironolactone, the tablets contain: magnesium stearate, colloidal silicon dioxide, milk sugar, talc and starch. Additional substances in capsules are: sodium lauryl sulfate, magnesium stearate, starch and lactose monohydrate.

Pharmacodynamics and pharmacokinetics

The action of the drug is based on the competitive ability of spironolactone to bind to receptors in the nephrons, before aldosterone, which is one of the main hormones synthesized in the cortical region of the kidneys. Its main function is the retention of fluid and sodium ions in the human body.

Spironolactone has the opposite effect - it promotes the removal of fluid and sodium, but at the same time retains potassium and, to a lesser extent, magnesium and urea, increasing their content in the blood.

As a result of taking the medicine, diuresis improves, urine acidity and high blood pressure decrease, and the work of the cardiovascular system normalizes. The drug maintains electrolyte balance, which is especially important for patients with pathologies of the heart and kidneys.

Veroshpiron has a mild effect, and the diuretic effect appears on the 2nd-5th day of taking the drug. But the hypotonic effect is manifested already in the first day after the start of treatment.

The drug is quickly and almost completely absorbed in the gastrointestinal tract, and the absorption rate is higher if the drug is taken simultaneously with food intake. After a single dose, the maximum plasma concentration of the active substance is reached no later than 6 hours later. If you take the drug daily for 15 days, then the concentration of the drug will reach 80 ng / ml.

Spironolactone is metabolized in the liver and excreted in the urine, with only a small amount of metabolites excreted through the intestines. One of the metabolites, carenone, is excreted in two steps. The first half-life lasts about 3 hours, the second - from 12 to 96 hours. The half-life is increased in patients with heart failure and cirrhosis.

Is it diuretic or not?

Veroshpiron belongs to diuretic drugs, but its purpose is not only to remove excess fluid, but also to reduce high blood pressure. Therefore, the drug is mainly prescribed for hypertension, renal hypertension and heart disease, accompanied by edema.

Indications and contraindications

The main purpose of Veroshpiron is to reduce pressure, mainly of the essential form. The drug is also indicated for other forms of hypertension, not only to reduce blood pressure, but also to prevent the development of complications from the heart and blood vessels.

Veroshpiron is part of mono- and combination therapy for pathologically increased aldosterone synthesis - hyperaldosteronism. This condition often develops with nephrotic syndrome and other kidney diseases, accompanied by swelling, ascites, cancer and prolonged starvation.

Long-term therapy is possible only with secondary hyperaldosteronism, and with the primary form of the disease, Veroshpiron is prescribed for a short period before preparing for surgical interventions.

The drug is used for potassium and magnesium deficiency caused by other diuretics and in cases where it is not possible to restore electrolyte balance with other drugs.

Veroshpiron is also prescribed for chronic heart failure, accompanied by edema. It can be used as the only drug for treatment, or as part of complex therapy.

Contraindications for admission:

Caution is required if the patient has AV blockade, diabetes mellitus and nephropathy on its background, metabolic acidosis, cirrhosis of the liver, liver failure and excess calcium in the body. It is also prescribed with extreme caution to elderly patients, women with menstrual irregularities, with an increase in the mammary glands and the need to use general and local anesthesia.

General instruction

The use of Veroshpiron requires extreme caution, because an overdose can lead to undesirable consequences. Therefore, the calculation of the dosage is possible only according to the instructions or recommendation of the doctor.

How to take: before or after meals?

The maximum therapeutic effect is achieved if the drug is taken during a meal or immediately after a meal. This method of application allows tablets and capsules to quickly dissolve and be absorbed into the bloodstream and in a short period of time to achieve the maximum concentration of the active substance in the blood.

It is best to take the medicine during breakfast, and with a double dose and during lunch. Drinking Veroshpiron in the evening is undesirable, as an improvement in diuresis will disrupt sleep patterns.

The use of tablets

The dosage depends on the disease, so it is best if the patient consults a doctor so that he selects the most appropriate treatment regimen. The annotation indicates the following dosages:

The drug can also be used in diagnostics. With a short test, the course of administration is 4 days, and with a long test, 3-4 weeks. At the same time, it is prescribed to take 400 mg per day, dividing the dosage into several doses.

In childhood, the dosage is selected based on body weight. Initially, appoint 1-3.3 mg / kg per day, divided into several doses. If necessary, the dosage is gradually increased, but not more than three times.

How to take capsules?

Capsules are taken in the same way as tablets. The only thing is that they can be taken if the daily dosage is at least 50 mg, since there are no capsules with an active ingredient content of 25 mg. If you need less than what is contained in the capsules, then it is recommended to purchase tablets rather than split the capsule, as it will not be possible to accurately calculate the dosage.

How long does therapy last?

Long-term therapy for each patient is selected individually. Usually the main course of treatment is 14 days, after which the dosage is gradually reduced, and the doctor decides whether to stop taking it or prescribe maintenance therapy in minimal doses. Veroshpiron can also be taken for a long time, as it acts very gently, but regularly monitors the level of electrolytes in the blood.

But the doctor, based on the patient's condition, may prescribe a longer treatment, add other drugs to the therapy regimen, increase or decrease the dosage and frequency of administration. Self-cancellation of the drug, an increase or decrease in dosage is unacceptable, since self-medication can lead to undesirable consequences, up to the death of the patient.

At what pressure and how to take?

The diuretic effect of Veroshpiron can reduce high blood pressure, so this drug is often included in the treatment regimens for hypertensive conditions.

With arterial hypertension

Veroshpiron is not considered mandatory for hypertension, but it is often prescribed if standard treatment regimens for hypertension do not give a positive result. Excess aldosterone is often the cause of the ineffectiveness of conventional treatments, and this can be found out using urine and blood tests for the amount of the hormone.

Experienced specialists do not prescribe Veroshpiron at the initial stage of hypertension. First, they try to cope with safer drugs.

Most often, Veroshpiron is prescribed for malignant or essential hypertension, when the pressure is kept above 140/90 and does not drop when taking other medications, or even rises even higher. In this case, it is added to an already used treatment regimen or prescribed as the only medication.

Depending on the indicators of blood pressure and the patient's condition, the doctor selects the required dosage. But the initial dose should not be less than 100 mg per day. The hypotensive effect is achieved 5 days after the start of treatment, but a stable result appears no earlier than 2 weeks later, in some patients later.

After the appearance of a stable result, patients are prescribed maintenance treatment - 25 mg per day. This dosage can be taken for a long time if it causes adverse reactions of the body. During the period of therapy, it is necessary to measure the pressure twice a day in order to monitor whether there is a positive effect from Veroshpiron or not.

With intracranial pressure

Veroshpiron is rarely prescribed for intracranial pressure, since its diuretic effect practically does not affect the level of fluid in the cranium. The use of the drug is justified only in combination with other drugs that affect the cause of the disease.

Usually, with intracranial pressure, it is prescribed in small dosages of 25-100 mg per day. After 5-10 days, the frequency of administration is reduced - it is recommended to take 25 mg every other day. With good results, the doctor may prescribe 25 mg every 3-4 days.

Despite the instructions limiting the intake of the drug by children under 3 years old, Veroshpiron is prescribed even for infants suffering from intracranial pressure. But its use in infancy should be under the supervision of a doctor and with regular blood tests.

With edema

Veroshpiron is very often prescribed to relieve swelling caused by diseases of the liver, kidneys and cardiac disorders. But, despite the benefits of the drug, its use is possible only as prescribed by the attending physician, since uncontrolled intake can lead to the development of side effects that threaten the patient's life.

The drug acts gently, and when used in therapeutic doses does not disrupt the functioning of the renal tubules and the work of the whole organism as a whole. Unlike most diuretics, Veroshpiron retains potassium, magnesium and urea, but removes sodium, chlorine and excess fluid.

The diuretic effect begins from the first day of admission, but the anti-edematous effect is observed after 5 days of treatment. As a result of the removal of edema, blood circulation normalizes, the increased load from the body is removed and pressure decreases.

But it is important to take the medicine in strictly prescribed dosages. Usually prescribed from 100 mg per day, and this dosage is recommended to be divided into 2 doses. With cirrhosis and the ratio of potassium and magnesium< 1,0 дозировка может быть увеличена до 400 мг в сутки, но оптимальной дозой считается 200-300 мг. Прием продолжается до наступления положительного результата, затем дозировку снижают и еще некоторое время принимают по 25 мг в день.

With chronic heart failure, the treatment course lasts 5 days, during which you need to drink 100-200 mg of the drug. Then prescribe maintenance therapy of 25 mg per day.

It is very important to follow some rules, especially when taking Veroshpiron for a long time - to monitor blood pressure daily and regularly take tests for electrolyte levels. In case of deviations or the development of side effects, you should immediately contact your doctor.

When treating edema at the same time as taking Veroshpiron, it is necessary to adhere to a certain diet - limit the use of foods containing a large amount of potassium so as not to cause its excess content in the body. Be sure to weigh yourself regularly - rapid weight loss can lead to a deterioration in general condition.

Veroshpiron for weight loss

By ridding the body of excess fluid, weight loss occurs, so many women often use Veroshpiron for weight loss. You should figure out whether the drug really helps to lose weight, and read the reviews.

Does it really help, and what are the possible consequences?

The method of losing weight with the help of diuretics, including Veroshpiron, has both supporters and opponents. Indeed, getting rid of excess fluid helps not only reduce weight, but also reduce volume. But it should be remembered that the drug does not affect body fat in any way, and the weight returns immediately after stopping the pills.

Therefore, this method is suitable only for those who urgently need to lose a few kilograms, for example, athletes drink Veroshpiron to get into the required weight category and improve muscle relief. Women take the drug before important events so that their favorite dress looks better on the figure.

To reduce weight, Veroshpiron can only be taken in small doses, not exceeding 50 mg per day. This dose can be taken in full in the morning or divided into 2 doses. The result appears on the 4th-5th day of admission, but the course of administration should be short - no more than 10-14 days.

To achieve the best result, you need to eat right: include more vegetables and fruits, protein products in the diet and reduce the amount of fat consumed.

Be sure to read the instructions and make sure that there are no contraindications to the drug. It can cause negative reactions that affect the work of the whole organism. Violations of the water and electrolyte balance lead to the development of diseases from the cardiovascular, digestive, urinary, nervous systems, hematopoiesis, malfunctions in digestion and urination, as well as problems with muscles and the musculoskeletal system.

Reviews

Reviews of patients taking Veroshpiron in order to lose weight say that the drug is ineffective and gives only a temporary result.

Elizabeth: “I drank Veroshpiron to get rid of edema and noticed that the weight began to decrease rapidly. Now I take pills for 1-2 weeks when I need to lose weight urgently. But the weight comes back very quickly, so for a long-term result, you need to completely change your lifestyle.

Olga: “I tried to drink Veroshpiron to get rid of extra pounds, but apart from the diuretic effect, I didn’t notice any other result.”

Mikhail: “I take diuretics when I urgently need to lose weight before the competition. Most of all I liked the result from Veroshpiron - it works gently, but effectively.

But doctors remind that the drug can harm health, so it should not be taken regularly, unless there is a medical indication for this.

Veroshpiron in gynecology and dermatology

Veroshpiron is sometimes used to treat diseases that are not listed in the instructions for use. So, Veroshpiron has found its application in gynecology. But it is used in combination with other medications that act directly on the cause of diseases.

With polycystic ovaries

Veroshpiron is used to treat polycystic ovaries, due to its properties to reduce the level of androgenic hormones in the body. With polycystic disease, the production of female hormones decreases and the synthesis of androgens increases. This leads to an increase in body weight, excessive hairiness, skin problems, a change in the timbre of the voice, the absence of menstruation and other unpleasant symptoms.

Veroshpiron inhibits the synthesis of androgens, helps to normalize hormones, reduce the symptoms of hirsutism and reduce body weight. To achieve a result, the drug must be taken for at least six months. Initially prescribed to take 100 mg 2-4 times a day. After achieving a stable result, the dosage is reduced and for some time it is prescribed to take 25 mg per day to maintain the result.

With mastopathy

Veroshpiron with mastopathy is prescribed to reduce swelling of the limbs and pain in the mammary glands, especially during the menstrual cycle. Any diuretics, including herbal ones, can be prescribed, but recent studies have shown that Veroshpiron is the most effective.

Clinical trials have shown that in addition to the diuretic effect, Veroshpiron has an immunosuppressive, antifibrotic, anti-inflammatory effect. It is these properties that allow the use of the drug in the treatment of fibrocystic mastopathy.

Taking the drug allows you to reverse the development of the cyst, restore the epithelium and bring the milk ducts back to normal. The dosage and duration of treatment is prescribed by the attending physician on an individual basis, as well as a combination of other drugs in the treatment regimen.

For acne

An increase in androgenic hormones in women leads to skin problems. It becomes oily, pores enlarge, acne appears. That is why gynecologists often advise their patients with hormonal disorders to take veroshpiron.

This drug does not contain hormones, but blocks the synthesis of androgens. Therefore, if there are no contraindications to taking Veroshpiron, it will help to quickly get rid of skin rashes. The attending physician, who has studied the tests and knows everything about the state of the woman's hormonal background, should select the dosage.

Reviews of women about the use of the drug

Many women doubt the effectiveness of Veroshpiron for acne and gynecological diseases. In most cases, this is due to the expectation of a quick result, although the drug must be taken in long courses. Here are the patient testimonials:

Marina: “Problems with the hormonal background began and the first sign was acne on the face. The endocrinologist prescribed Veroshpiron and Iodomarin. The result appeared only after 2 months - acne began to gradually disappear. I retaken the tests after 4 months - almost all the indicators were normal.

Anna: “I have been taking Veroshpiron for almost two months now, my hair and skin have become less greasy, but so far it has not helped with hirsutism. The doctor said that you need to take a few more months for the result to appear. ”

Women who use Veroshpiron for 1-2 months and do not notice the result stop treatment and begin to talk about the ineffectiveness of the drug. But this is the wrong decision - in order to normalize the hormonal background, a longer intake of the drug is needed.

Admission during pregnancy and childhood

The annotation states that taking Veroshpiron during pregnancy is unacceptable, but some experts still prescribe it to expectant mothers. When drugs are prescribed that are prohibited for pregnant women, it is recommended to visit another specialist and if it turns out that it is impossible to replace the drug with a safer remedy, treatment can be started.

There are a lot of drugs with an action similar to Veroshpiron, so it is rarely possible to choose drugs that have a less negative effect on the fetus. Therefore, Veroshpiron is prescribed if other drugs do not give the desired result or the woman has an increased sensitivity to them.

It should be understood that Veroshpiron is contraindicated in pregnant women only because of the insufficient number of studies. In clinical practice, there have not yet been cases where the drug had a negative effect on the course of pregnancy or fetal development. Therefore, if you need to drink Veroshpiron during pregnancy, then you must follow the doctor's recommendations.

Veroshpiron gained great popularity in the treatment of gynecological diseases accompanied by infertility. The drug, acting on androgen receptors, brings the hormonal background back to normal and gives a woman the opportunity to become pregnant and bear a child.

The drug is also used to treat children. The instruction indicates that the drug is prohibited for children under 3 years old, but in practice the drug is used even to treat newborns, including premature babies. Such treatment should only take place under the supervision of specialists with regular blood tests.

For children who cannot swallow tablets, the drug is crushed and mixed with water or milk. Capsules are prescribed no earlier than the child is 5-6 years old, due to swallowing difficulties in young children. The dosage is selected individually, based on the body weight of the child and the presence of concomitant diseases.

Possible harm and precautions

Veroshpiron should be taken with extreme caution, as it can cause adverse reactions and overdose symptoms, especially if used incorrectly.

Side effects

Adverse reactions:

With prolonged use, gynecomastia develops in men, but disappears some time after the drug is discontinued. Veroshpiron can lead to decreased libido and impotence.

Negative reactions in women

The most common consequence of taking Veroshpiron in women is a violation of the menstrual cycle, up to amenorrhea. During menstruation, severe pain and cramps in the lower abdomen may appear, accompanied by nausea, migraines and a general deterioration in the condition.

Other reactions are postmenopausal metrorrhagia, increased body hair growth, discomfort and pain in the mammary glands. At the moment, studies are underway on the relationship between Veroshpiron and the development of breast carcinoma, but the connection has not yet been established.

Overdose

Overdose symptoms occur due to electrolyte imbalance. They are expressed:

• headaches;
• a decrease in pressure;
• drowsiness.

In addition, muscle pain, dry mouth, gastrointestinal upset, arrhythmia develop, and a rash on the skin may appear. In case of an overdose, urgent restoration of water and electrolyte balance is necessary, and in severe situations - hemodialysis.

Alcohol compatibility

It is not recommended to combine Veroshpiron and alcohol, since alcoholic beverages negatively affect the functioning of the heart and increase the load on the kidneys. This combination can lead to both temporary reactions of the body, and completely worsen the state of health.

Alcohol retains fluid in the body, and the drug can not cope with its withdrawal, resulting in edema. Pressure begins to rise, blood vessels suffer, brain receptors are irritated. As a complication, an acute cerebral circulatory disorder or myocardial infarction develops.

But, according to the observations of many patients, you can cope with a hangover if you drink plenty of water, as well as a Veroshpiron tablet. This method helps to remove excess water and toxic breakdown products of alcohol from the body. Men can take pills no earlier than 14 hours after drinking alcohol, and women only after 20 hours.

Analogues

Among the analogues of Veroshpiron, one can name both structural ones that have the same effect and have similar limitations, and preparations based on other active ingredients with a similar effect. You should consider which of the analogues is better and cheaper.

Structural

The active substance of Veroshpiron is spironolactone. On its basis, other diuretic drugs have been created, but produced under various trade names.

List of analogues and prices:

But doctors note that Veroshpiron is the most effective and less likely to cause negative phenomena than its structural counterparts. It is possible that this is due to a higher degree of purification.

Drugs with a similar effect

Among other drugs, the most popular drugs with a similar effect should be noted (Table 2).

Table 2 - Non-structural analogues of Veroshpiron

Name	Active ingredient, group	Main indications	average price
		Myocardial infarction, CHF, hypertension.	540-900 rub.
Decriz (similar to Eridanus)	Eplerenone, a potassium-sparing diuretic.	Myocardial infarction, CHF, left ventricular dysfunction.	300-500 UAH (Sold mainly in Poland and Ukraine)
	Hydrochlorothiazide, a thiazide diuretic.	Hypertension, puffiness, prevention of urolithiasis.	35-130 rub.
	Indapamide, diuretic, antihypertensive agent.	Arterial hypertension, including renal origin.	24-400 rub.

Which drug is better is hard to say. Each drug has its own characteristics, contraindications and indications, so the choice of treatment depends on the attending physician. But the undoubted advantage of such diuretics is that they affect the electrolyte balance to a lesser extent.

Veroshpiron is a diuretic used in the treatment of diseases accompanied by severe tissue edema. Potassium-sparing diuretic is a long-acting diuretic that helps eliminate fluids, sodium, and minimizes potassium loss from the body.

It is worth highlighting the following indications for the use of the drug Veroshpiron:

• Swelling due to heart failure;
• Persistent increase in arterial and blood pressure;
• Conn's syndrome;
• Ascites;
• Hypokalemia.

In addition, the drug Veroshpiron is prescribed for diagnostics, testing for hyperaldosteronism.

Instructions for use

The drug should be given to the child in the morning, during meals or immediately after a meal, or in the afternoon. If you take the medicine before going to bed in the evening, the regimen is violated. Capsules or tablets should be swallowed whole, without chewing, with water.

You should change your diet during the course of treatment with Veroshpiron. Instructions for its use prohibits the use of large volumes of foods with excessive amounts of potassium, and salt should also be consumed sparingly.

In old age, in the presence of serious ailments of the kidneys, liver, it is necessary to constantly control the activity of the kidneys. This also applies to those patients who, while taking these pills, additionally use non-steroidal, anti-inflammatory drugs.

Dosage

Depending on the disease, the doctor prescribes Veroshpiron at a dosage of 25 mg or 50, as well as 100 mg. It all depends on what diagnosis was made, how severe the patient's condition is. The duration of the course of admission is strictly individual.

The child should drink the medicine twice a day, with an interval of 10 or even 12 hours. You can not take Veroshpiron for children under one year old, only from the age of three is recommended treatment using this remedy. If there are certain indications, the doctor may decide to prescribe Veroshpiron to infants, premature babies. It is important that the doctor monitors the patient's condition. Most often, a child is treated with the use of tablets, they can be crushed, mixed in water, milk.

With swelling, the dosage for the initial period of treatment is from 1 to 3 mg per kilogram of weight, divided into several doses - from 1 to 4. After 5 days, the dosage is adjusted, it can be increased by 3 times. This takes into account how effective the therapeutic effect of the drug was during this period of time.

Contraindications

Of the obvious contraindications in the treatment of diseases for the use of Verospiron for children, it is necessary to highlight:

• Excessive sensitivity to the components of the drug;
• Anuriy;
• Lack of sodium in the blood or excess potassium;
• Poor digestibility of glucose and galactose.

With caution, children are prescribed the drug for:

• in blood;
• Hypercalcemia;
• liver failure.

For adults, the prohibition to take the drug is:

• The period of gestation;
• Lactation.

Control is especially important if the medication is used:

• After operations;
• With irregular menstruation;
• In the presence of cirrhosis of the liver;
• If the mammary glands are enlarged.

Overdose

As a result of an overdose in childhood, side effects increase. Drowsiness increases, weakness appears, symptoms are possible: there is no saliva, dry skin is observed, indigestion, vomiting is possible. You should immediately stop taking the medicine and rinse the stomach, then call a doctor or an ambulance.

Analogues

When prescribing treatment with the drug Veroshpiron, the price of which is acceptable, analogues are possible. Their dosage should also be agreed with the doctor. Self-medication is unacceptable. Of the analogues, it should be distinguished:

• Aldactone and Spirix;
• Uroston.

Other drugs with the same constituent component, Spironolactone, act similarly. Before choosing an analogue of the drug, you should consult a doctor.

• Read more:

Price

The cost of Veroshpiron is not the same everywhere. Check in pharmacies - from 90 to 300 rubles.

"Veroshpiron" is a popular diuretic, often prescribed by adults for high blood pressure or edema. Let's try to figure out whether it is possible to treat babies with such a drug and when it is used in childhood.

Release form

"Veroshpiron" is produced in two forms:

• Tablets. They have a flat round shape, almost white color, a characteristic smell and have the inscription VEROSPIRON on one of the sides. One package contains 20 tablets.
• Capsules. They are made of gelatin, and inside there is a powdery white substance. The color of the capsules indicates the dosage of the drug (with a smaller dose - white, with a larger one - yellow-orange), and one pack contains 30 of them.

Compound

The main ingredient of "Veroshpiron" is spironolactone. Such a substance in one tablet is represented by a dosage of 25 mg, and capsules are produced with a content of spironolactone at a dose of 50 or 100 mg.

In both forms of the drug, manufacturers included lactose, cornstarch and magnesium stearate. In addition, the tablets contain colloidal silicon dioxide and talc, and the capsules contain sodium lauryl sulfate, gelatin and coloring components.

Operating principle

The main effect of "Veroshpiron" is diuretic. It does not appear immediately, but from the second day of treatment, resulting in a decrease in pressure. At the same time, the drug counteracts such an adrenal hormone as aldosterone, so that the body does not lose a lot of potassium and magnesium in the urine. Once in the kidney cells, the drug does not allow aldosterone to retain water, chlorine and sodium, but blocks the excessive excretion of urea and potassium, due to which the acidity of the urine decreases.

Indications

Treatment with "Veroshpiron" is prescribed:

• With edema.
• With increased blood pressure.
• With low potassium levels.
• With hyperaldosteronism.

At what age is it allowed to take?

"Veroshpiron" is not recommended for children under 3 years of age. However, the doctor may prescribe such a medicine at an earlier age (infants and even premature babies), if there are indications for this. A child under three years old must be supervised by a specialist.

Contraindications

The drug is not prescribed for children with:

• Severe renal failure.
• Hypersensitivity to spironolactone or any other component of the drug.
• Anuria.
• Lack of lactase.
• Decreased sodium levels in the blood or high amounts of potassium.
• Problems with the absorption of glucose or galactose.
• Addison's disease.

If a small patient has been diagnosed with diabetes mellitus, AV blockade, hypercalcemia, or liver failure, Veroshpiron should be used very carefully. Increased attention also requires the use of medication after surgery.

Side effects

During the reception of "Veroshpiron" the appearance of:

• Loose stools, abdominal pain, vomiting and other negative symptoms from the digestive tract.
• Dizziness, lethargy, drowsiness, headaches.
• Changes in blood tests: a decrease in the level of granulocytes, an increase in the level of potassium, urea, creatinine, a decrease in the number of platelets.
• Roughening of the voice.
• Allergies in the form of urticaria.
• Hair loss.
• Kidney disorders.
• Muscle spasms.

Instructions for use and dosage

The drug should be swallowed and washed down with water. It is not advised to bite or chew the capsules, so they are prescribed only to those children who can easily swallow such a drug. Toddlers under 6 years old are often prescribed tablets, since they can be crushed into powder if necessary and mixed with water or milk.

The best time to take it is morning or afternoon. Tablets should be taken with meals or immediately after meals. Treatment of edema in children begins with a dosage of 1 to 3 mg of the active ingredient per kilogram of weight. After five days, the required dosage is adjusted, taking into account the therapeutic effect of the drug. If the medication is prescribed for other pathologies, the dose and frequency of administration should be determined individually.

Overdose

If a child is given the wrong dose, causing them to take more spironolactone, this will lead to dizziness, nausea, low blood pressure, dry mouth, muscle weakness, skin rashes, and other overdose symptoms. For treatment, you should flush the stomach and give the patient drugs that normalize the level of electrolytes and fluids. If the condition is severe, resort to hemodialysis.