Is it possible to combine dioxidine with alcohol. Myths and reality about combining antibiotics with alcohol. Prohibition violated: what to do

All people get sick from time to time, and many of them have to resort to taking antibiotics. It is widely believed in society that these drugs are incompatible with alcohol, but what if the treatment period coincided with the holidays? Where is the truth, and where is the legend in our understanding of the interaction of antibiotics with alcoholic beverages?

Antibiotics and alcohol

Antibiotics are medicines designed to fight bacteria. They penetrate pathogenic microorganisms or interfere with their metabolism, disrupting it completely or partially.

The question of the compatibility of antibiotics with alcohol and regarding when you can drink after therapy, doctors still have different attitudes. There are many doctors who strongly recommend that patients completely exclude alcoholic beverages during therapy in order to avoid. They explain this by the fact that these drugs, together with ethanol, destroy the liver and negate the effectiveness of the treatment.

To date, many studies have been carried out, the results of which allow us to boldly assert that the pharmacological effect of most antibiotics under the influence of alcohol does not worsen, and the load on the liver does not increase.

However, alcohol itself causes intoxication and dehydration. If you drink antibiotics with large doses of alcohol, the body will weaken, and in this case, the effectiveness of treatment, of course, will decrease.

A number of antibiotics are also isolated, which enter into a disulfiram-like reaction with ethanol. Their simultaneous intake with alcohol is contraindicated, as this will cause intoxication, accompanied by nausea and vomiting, convulsions. In very rare cases, death is possible.

Myths and reality

Historically, there have been myths in society about the complications of drinking alcohol during antibiotic treatment.

The main myths are as follows:

• Alcohol neutralizes the effect of antibiotics.
• Alcohol, along with antibiotics, increases liver damage.
• Alcoholic drinks reduce the effectiveness of experimental therapy.

In fact, these theses are only partially true, which is confirmed by the results of numerous studies on compatibility. In particular, the available data suggest that the intake of alcoholic beverages does not affect the pharmacokinetics of most antibiotics.

At the turn of the 20th and 21st centuries, a lot of research was carried out on the combined action of antibacterial drugs and alcohol. The experiments involved humans and laboratory animals. The results of antibiotic therapy were the same in the experimental and control groups, but there were no significant deviations in the absorption, distribution and excretion of the active substances of the drugs from the body. The data from these studies showed that it is possible to drink alcohol while taking antibiotics.

Back in 1982, Finnish scientists conducted a series of experiments among volunteers, the results of which showed that the antibiotics of the penicillin group do not enter into any reactions with ethanol, so you can use them with alcohol. In 1988, Spanish researchers tested amoxicillin for compatibility with alcohol: only insignificant changes in the rate of absorption of the substance and the delay time were found in a group of subjects.

In addition, at different times, scientists from different countries made similar conclusions about erythromycin, cefpirome, azithromycin and many other antibacterial drugs. It was also found that the pharmacokinetic parameters of some antibiotics - for example, the tetracycline group, are significantly reduced under the influence of alcohol. However, fewer drugs with this effect have been identified.

The common belief that alcoholic beverages, along with alcohol, increase liver damage, is also refuted by scientists around the world. Rather, alcohol can increase the hepatoxicity of antibacterial drugs, but only in very rare cases. This fact becomes the exception rather than the rule.

The scientists also proved that ethanol has no effect on the antibiotics azithromycin, travofloxacin and ceftriaxone, used in the treatment of experimental pneumococcal infection among experimental rats. Interesting results were obtained during experiments with moxifloxacin: it turned out that rats that received small doses of alcohol during the drug intake were cured faster.
Why is it common to say that alcohol and antibiotics are incompatible:

Reasons for incompatibility

Despite the fact that the safety of the simultaneous use of most antibiotics along with alcohol has been proven, a number are distinguished. These are drugs whose active substances enter into a disulfiram-like reaction with ethyl alcohol - primarily nitroimidazoles and cephalosporins.

The reason why it is impossible to take both antibiotics and alcohol at the same time lies in the fact that the composition of the above drugs contains specific molecules that can change the exchange of ethanol. As a result, there is a delay in the excretion of acetaldehyde, which accumulates in the body and leads to intoxication.

The process is accompanied by characteristic symptoms:

• intense headache;
• rapid heartbeat;
• nausea with vomiting;
• heat in the areas of the face, neck, chest;
• difficult breathing;
• convulsions.

A disulfiram-like reaction is used in coding for alcoholism, but this method should only be used under the strict supervision of a specialist. Even a small dose of alcohol causes poisoning during treatment with nitroimidazoles and cephalosporins. Alcohol abuse in this case can result in death.

Doctors allow a small amount of alcohol in the treatment with penicillins, antifungal drugs, and some broad-spectrum antibiotics. A serving of a fortified drink while taking these drugs will not affect the effectiveness of therapy and will not cause negative health effects.

When can

Although alcohol is allowed with most antibiotics, they should not be taken at the same time. The better to drink such drugs, it is indicated in the instructions. For example, the effectiveness of erythromycin and tetracyclines increases drinking alkaline mineral water, and sulfonamides, indomethacin and reserpine - with milk.

If the antibiotic does not enter into a disulfiram-like reaction with ethanol, you can drink alcohol, but not earlier than 4 hours after the drug. This is the minimum time that antibiotics circulate in the blood, respectively, and is the answer to the question of how much you can drink after taking the drug. In any case, during the treatment period, it is allowed to take only a small dose of alcohol, otherwise dehydration will begin in the body, and the antibacterial drug will simply be excreted in the urine.

conclusions

The myth of the incompatibility of antibiotics and alcohol appeared in the last century, while there are several hypotheses about the reasons for its occurrence. According to one of them, the authorship of the legend belongs to venereologists who wanted to warn their patients against drunkenness.

There is also an assumption that the myth was invented by European doctors. Penicillin was a drug in short supply in the 1940s, and soldiers liked to drink beer, which has a diuretic effect and removes the drug from the body.

It has now been proven that alcohol in most cases does not affect the effectiveness of antibiotics and does not increase liver damage. If the active substances of the drug do not enter into a disulfiram-like reaction with ethanol, you can drink alcohol during treatment. However, 2 main rules should be observed: do not abuse alcohol and do not drink an antibiotic with it.

Many people have a question, is it possible to drink alcohol while taking antibiotics. After all, there is an opinion that drugs lose their effectiveness if they are taken with alcohol. Another point of view argues that alcohol and antibiotics are incompatible and are a deadly combination.

Alcohol poisons the cells of the body, disrupts their ability to recover and regenerate, leads to fatigue and dehydration, which negatively affects the diseased body. And although alcohol does not completely nullify the effect of drugs, the recovery process greatly slows down. This is one of the reasons why you shouldn't drink alcohol with antibiotics. Since beer is also a type of alcoholic beverage, everything said about alcohol and antibiotics certainly applies to beer and is the answer to the question of whether beer can be with antibiotics.

Also, the use of alcohol during antibiotic treatment can have a negative effect on health: when they interact inside the body, an undesirable result can be obtained. Which one depends not only on the type of alcohol and antibiotics (for example, antibiotics and beer), but also on the individual characteristics of the body, primarily metabolism.

Alcohol and antibiotics are somewhat similar in their effect on human metabolism and have some similar side effects: dizziness, drowsiness, indigestion. That's why if you drink alcohol along with antibiotics, alcohol can increase the side effects of drugs.

Some antibiotics suppress the central nervous system, causing drowsiness, dizziness, relaxation, and confusion. Alcohol is also a central nervous system depressant. With antibiotic treatment, this side effect is exacerbated. This is fraught with dangerous consequences while driving a car (which in itself is unacceptable if a person has drunk), as well as for older people, who often take several different types of medication at the same time. Including relieve anxiety, anxiety, strong painkillers, tranquilizers.

Effect on liver enzymes

Ethanol and many antibiotics are broken down by the same enzymes that are produced in the liver. If you ask the question whether it is possible to drink alcohol in combination with antibiotics, then you should know that under the simultaneous influence of these two substances, the production of the enzyme can be stopped. This means that neither alcohol nor the drug will be completely broken down and excreted from the body, which can lead to serious consequences. Among them is the accumulation of alcohol in the blood and an increase in its content to a dangerous level for health, when the possibility of poisoning increases.

Another picture can be observed when, with alcohol abuse, liver enzymes become hyperactive. This means that during antibiotic treatment, they will decompose the medicine so quickly that the antibiotic will be excreted from the body without producing the desired therapeutic effect.

When the ban is categorical

Some people still violate the ban, and drink alcohol during antibiotic treatment. But they should know that there are drugs that are absolutely impossible to mix with alcohol: when interacting with alcohol, they lead to unpleasant side effects. These include:

• Metronidazole.
• Tinidazole.
• Ethionamide.
• Cycloserine.
• Cefotetan.
• Thalidomide.

Metronidazole (Flagil) is prescribed to treat dental and vaginal infections, ulcers, and pressure sores. Tinidazole (Tindamax) is used in the same cases as metronidazole and for the treatment of infections of the gastrointestinal tract. Cefotetan is used to treat infections of the lungs, gastrointestinal tract, bones, joints, blood, urinary canal, and skin.

These antibiotics, when interacting with alcohol, cause severe cramps in the stomach, nausea, vomiting, headache, flushing to the head, chest pain, tachycardia.

All of the above symptoms almost coincide with the side effects caused by disulfiram, which is used to treat alcoholism by drug coding. When treated with disulfiram, even a small dose of alcohol is enough to cause these symptoms.

When treating with metronidazole, tinidazole and cefotetan, it is necessary to completely exclude alcoholic beverages from drinking. Be sure to refrain from using them for three days after taking the last dose of antibiotics.

The use of alcohol during treatment with cycloserine and ethionamide can lead to toxic effects on the central nervous system and inhibit motor functions. Isoniacid has a toxic effect on people who chronically abuse alcohol and increases their risk of liver damage.

The effect of combining drugs with alcohol

The compatibility of antibiotics and alcohol becomes clear from the table below, which describes the effect of their interaction. It will allow you to understand whether it is possible to drink alcohol while taking antibiotics and whether alcohol can negatively affect the body:

Medicine	The effect of combining with alcohol	Recommendation
Sulfamethoxazole/ trimethoprim (bactrim, septra)	Tachycardia, Attacks of hot flashes and redness of the skin,	Avoid alcohol while taking sulfamethoxazole/trimethoprim
Metronidazole (Flagil), Tinidazole (Tindamax), Cefotetan (Cefotan)	Disulfiram reactions: cramps in the abdominal region, headache, flushing.	Avoid alcohol during treatment and for 72 hours after the last dose of metronidazole, tinidazole, cefotetan
Linezolid (Zyvox)	Increased risk of arterial hypertension	Avoid drinking alcoholic beverages, especially those containing tyramine (beer, vermouth, red wine)
Rifampin (rifadin)	Risk of liver poisoning	Do not use with alcohol
Isoniacid (Nidrazide)	Increased risk of liver poisoning with daily alcohol consumption	Avoid drinking alcohol with isoniacid
Cycloserine (seromycin)	The combination with alcohol can lead to toxicosis of the central nervous system, seizures and convulsions.	Avoid drinking alcohol with cycloserine
Ethionamide (tracker)	Possible toxicosis of the central nervous system, the development of psychosis	Avoid alcohol during treatment with ethionamide
Voriconazole (fivend)	Changes in liver metabolism	Avoid alcohol during treatment with voriconazole
Ketoconazole (Nizoral)	Liver toxicosis and the appearance of disulfiram reactions are possible: cramps in the abdominal region, headache, flushes of blood.	Avoid drinking alcohol during treatment with ketoconazole
Pyrazinamide	Possible liver toxicity	Treatment with pyrazinamide is prohibited for alcoholics or systematic drinkers
Thalidomide (thalomid)	Increased risk of increased sedative side effects of thalidomide - drowsiness, confusion. Do not use for drivers and machine operators.	Avoid alcohol during treatment with thalidomide

There are antibiotics that do not cause an extremely negative effect in non-drinkers or occasional drinkers. But they can cause dangerous side effects in chronic alcoholics (this also applies to beer alcoholism) and systematic drinkers.

If such people take alcohol at the same time as antibiotics such as rifamine, pyrazinamide, voriconazole, liver damage can be provoked. Also, they should not take alcohol with didanosine due to an increased risk of pancreatitis or worsening of its course, which accompanies all the ensuing consequences. The same applies to the answer to the question whether it is possible to drink beer.

Prohibition violated: what to do?

If we talk about what will happen if the ban was violated and the person took antibiotics and alcohol at the same time, then you should know that the strength of the manifestations of side effects largely depends on the general state of health, the amount of alcohol consumed, and the ability of the liver to utilize these substances. Not all of the consequences are pronounced, but in the worst case, a fatal outcome is possible.

If the prohibition was violated, and an adverse reaction occurred, you should immediately call an ambulance. This is the only correct way out in case of consequences from mixing ethanol with antibiotics. Severe symptoms after antibiotics and alcohol are:

• shallow breathing;
• chest pain;
• irregular heartbeats;
• dizziness;
• nausea;
• vomit.

Since the possibility of interaction between alcohol and antibiotics can be fatal, the appearance of the above symptoms requires immediate medical attention. If a person with these signs is left without timely medical attention, the consequences can be fatal. For example, an arrhythmia can lead to cardiac arrest, and dehydration due to vomiting causes blood pressure to drop to dangerous levels.

Please write in what doses you can take the drugs you indicated for high blood pressure:

You can reduce high blood pressure by taking antihypertensive drugs (adelfan, capoten, caposide, magnesium sulfate, etc.). A positive effect is given by diuretics (diacarb, glycerin, triampur).

To compensate for potassium deficiency, panangin (asparkam), calinor is indicated.

Ok, what can happen if the quantity is exceeded? Say, if you eat 3-4 eggs a day?

Pavel, if everything is fine with the bile outflow, then nothing may happen. Another thing is that four eggs a day will create an excess of protein, and this in itself is a burden on the liver. And premature aging

1. 4 eggs is inevitably too much protein? or if the rest of the diet is poor in protein, then you can achieve a balanced diet?

2. "Liver stress" in and of itself isn't dangerous as long as the liver isn't damaged, right?

Pavel, after 25 years, an excess of protein is more than a gram per kilogram of weight per day, that is, 4 eggs is an average of a third of the daily requirement. And there is also bread, cereals, milk, fish-meat. Count yourself.

Can a scratchy throat be caused by strong drinks?

Stanislav, a few months ago he switched to strong drinks. I drink once a week up to 500 grams, usually either a little clean or slightly diluted with juice. I noticed that on other days my throat is a little ticklish and occasionally I cough. Is there a connection? And if so, what syrup or other drug can you recommend? Thank you.

Sasha, theoretically there may be a connection, but you cannot establish it in absentia. I think your reason is different.

How to remove hand tremor after drinking?

Greetings, please advise, please, how to remove hand tremor after drinking quickly and immediately? The state of health is normal, and the hands can tremble for a long time, it infuriates and causes discomfort. Will Corvalol in tablets help?

Vitalik, quickly and immediately it definitely won’t work

How many days can I drink alcohol after a tetanus shot?

How many days can I drink alcohol after a tetanus shot? Thanks in advance!

Three days is enough

I take lenuksin, phenibut, cytoflavin and mexidol. Is alcohol allowed?

Good evening. I have been taking Lenuxin, Phenibut, Cytoflavin and Mexidol for three weeks now (doctor's prescription). Is it possible to drink alcohol sometimes or absolutely not?

How does ginseng speed up the metabolism of alcohol?

Stanislav, welcome. What mechanism do you think ensures the acceleration of the metabolism of alcohol and acetaldehyde when taking ginseng? https://www.ncbi.nlm.nih.gov/pubmed/24458173

And will it work for non-Asians?

Hello Pavel. This occurs due to the stimulation of nonspecific activity of the CNS, and as a result, the enhancement of the effectiveness of neurotrophic control. It will work for non-Asians.

Is it true that heroin can relieve alcohol withdrawal symptoms?

Hello doctors! The question is: is it true that heroin can relieve alcohol withdrawal syndrome? Heard a lot of stories in NA groups, just wondering the professional point of view.

Vitaly, discussed many times. In general, a stronger drug removes withdrawal symptoms from a weaker one. It's just that it doesn't matter in practice.

Strong reaction to alcohol: nervous and skin

Maybe you are wondering as a pro: A hangover begins a few hours after the first dose, I drink constantly without limiting myself - 1.5 liters of vodka (wine, beer do not work at all) per day, day and night, then, after ten days, vodka ceases to act, uncontrollable hiccups begin. Sleep disappears, and outside the window the highway turns into a singing choir. They sing beautifully and well. It's time to go, call a taxi and go to the psychiatric hospital. They give me some kind of pill, I sleep for seven hours, then a couple of droppers, and two days later I go home. Three days after discharge, the devilry begins with the skin, nails and eyes - the skin on the palms and feet peels off in shreds, the nails also fall apart and fall off, some kind of solid substance appears in the eyes, such as hardened gypsum, it is very annoying, you scrape it off every minute with water. In two weeks everything will be back to normal. 26 years already, but I can’t deduct the reason anywhere, I think it’s some kind of allergy to the decay products of alcohol. I've never seen anyone else like this in my life, I'm probably the only one like that. Working. Have you experienced this? Thank you.

Bertrand, it happens. And even more pronounced.

Are there weight limits for gender and age?

Stanislav, there are certain weight norms for gender and age. But what if a person by nature does not fit into these norms - does it mean that he should strive to gain / lose weight? Is there, in general, some kind of weight threshold (in one direction or another), when can we talk about pathology and a person needs to think? If there is, then you can link. Thank you.

There is a concept of "body mass index". Wikipedia, for example, cites WHO recommendations regarding the concept of a normal BMI: https://ru.wikipedia.org/wiki/Body_Mass_Index

Sasha, there are norms not only for gender and age. They are calculated, among other things, based on bone thickness, height, fat folds and general physique.

How to boost immunity after quitting drinking?

Good day! I'm not sure if the question will be addressed, although it relates to the subject of the site. In the spring of this year, he was coded, since then he has not consumed alcohol. I'm 37, I've been drinking regularly all my adult life and drinking a lot, despite rather poor health. Could you advise something on how to raise immunity without forcing yourself to play sports. The body was torn out of its usual state, now I just can’t get back to normal. Persistent colds. Not only is every day a struggle with yourself because of a craving that hasn’t gone anywhere, but also this. I tried to drink some pills prescribed by the therapist, nothing helps. Thanks in advance for any answer! Sincerely, Vitaly.

BonusKomsa, "raping yourself with sports" does not strengthen the immune system. With excessive physical exertion, inhibition of the body's immunological reactivity is observed. But dosed loads that correspond to age and level of physical fitness benefit the body. You can just run in the mornings / evenings, go to the pool several times a week, or limit yourself to morning exercises followed by a contrast shower. In addition, physical activity helps to switch attention and is a great distraction from “bad thoughts”, which will help reduce cravings for alcohol.

More specifically, I can advise taking vitamins. And first of all, it is vitamin C. You can supplement it with vitamins A and E. Try echinacea, only in the form of a decoction - not tinctures, since it is on alcohol.

As for modern immunostimulants, I would not trust them much. It is only in advertising on TV that Anaferon and similar drugs position themselves as a panacea for all diseases. In fact, the appointment of any immunostimulant is very individual and can have a number of side effects. Therefore, without a complete examination of the body, it is not worth using them in packs, in the hope of strengthening immunity.

Anaferon is generally a hidden homeopathy. From the instructions: "The active form of the active substance is the active form with a content of not more than 10-15 ng / g of the active substance." There is not a single molecule of medicine in Anaferon, that is, it is obviously a dummy.

I am currently writing on my own. The fact is that I do not share the negative attitude of the site administrator towards homeopathy. It may be considered pseudoscience by some commission from the Higher School of Economics, but clinical practice shows that it works. Not everything pseudoscientific does not exist.

And, if we are already talking about molecules, then in addition to chemistry, there is also physics, and there is computer science.

Why don't doctors prescribe phenobarbital after drinking?

Dear doctors, why in medical practice after binges they give phenazepam, and not phenobarbital, because it relieves convulsions more effectively, relieves tachycardia, is more effective in terms of sedation?

Vlad, and phenobarbital kills more effectively

But after all speech not about its systematic use. I’ll just note from my own experience that when you get out of a binge, it relieves anxiety and tremor well and helps you fall asleep, after which you feel much better and don’t want to drink. Phenazepam in this plan is inferior to him.

"when you get out of a binge, it relieves anxiety and tremor well and helps you fall asleep"

Vlad, this is not always a selection criterion. To make the idea clear, I’ll say for comparison that droperidol with fentanyl could even better relieve anxiety and a headache with a hangover. :)

Well, for some reason, it is phenobarbital that is used in Popov's mixture. Your site is very exaggerated about phenobarbital!

Vitaly, Popov's mixture is used in specialized hospitals under conditions of intensive observation. What kind of thickening of colors can be here?

How to overcome alcoholism?

Hello. I am a latent alcoholic. I am writing because tears are already rolling - I can’t go on like this. I'm 36 years old. I have been drinking for 15 years with interruptions for only 2 pregnancies. I used to get drunk with my first husband, heavily, to the point of insanity. Thank God, I decided to breed. She married a second time to a non-drinking wonderful man. But she didn't overcome her alcoholism. For the last 8 years I have been drinking moderately, not to the point of being super drunk, but every evening. I promise myself every morning that today I will come home without alcohol, but after work I still buy it. And I kill myself and the time allotted to the family. I drink either beer or strong, diluted, it takes just 3-4 hours for 250g of vodka. Every day. Every single day for 8 years. I'm ashamed. It is a shame that children grow up without my attention, my husband is also offended. I can't put into words how I feel......but I know that in the evening everything will be the same again. How? How to stop it? Help me please!

Good afternoon. Before the doctor answers, let me put in five cents. It is unlikely that in your case the advice given on the Internet can change the whole situation. I advise you to find a good specialist in your city (narcologist and / or psychotherapist) and work with him.

Latentnaya, I'm afraid that the Admin is right - such problems are not solved in absentia and on the Internet. After all, it is necessary to identify the cause of your addiction and eliminate it, and this requires individual work and long-term treatment.

From myself, I can recommend the only thing - try to find a hobby with your children, and spend the time that you spend on daily drinking with benefit. Perhaps this will distract you and help you resist your own habit. If not, then seek help from a psychotherapist and narcologist without wasting time.

What is the difference between different multivitamins?

Stanislav, are standard multivitamins globally different in any way? Prices are so different... There is a difference in price of 10-30 times! Is there a significant difference between them or is it all marketing and brandophilia?

Sasha, well, they differ in composition. When there are a lot of components, it is more difficult to make a dragee or a tablet, and the drug will be more expensive. Not 30 times, of course.

And drug prices are generally a phenomenon far from technology. With rare exceptions.

Husband works on plants. How to protect yourself from toxic substances?

hello, please tell me, my husband at work is now involved in the processing of crops, they immediately use Micro AS Boron, Microfeed AdyuGold, Cosmicturbo. They mix everything together. He brings containers, refills, takes away. works in a special suit, gloves, respirator. clothes under the suit, takes off at work, puts on other clothes and already then goes home. naturally washes his hands. immediately bathes at home

Is there a danger to a child (child 1 year old) at home? I'm afraid, because the child crawls everywhere, walks, wears toys, throws, can immediately pick up a toy and put it in her mouth.

is there any chance that in this way some particles of hazardous substances will get home from clothes, crumble? How dangerous are these substances?

how to keep a child safe?

boyaka, hello, but how does a small child participate in this? why should it be secure?

Stanislav, from the text of the question it seems to follow that the child is at home and "particles of dangerous substances will get home from clothes, crumble"

and dried particles from clothes can get on the floor and the handle of the front door and, accordingly, we will carry it all further around the house. and the child crawls, then toys are everywhere in the house, she drags them into her mouth, she can lie on the floor, well, like everyone else age. or if these substances got on the clothes, then everything dried up?

I read there are hazard classes, how dangerous are these substances

and for the husband overalls, is this a respirator enough for his work? there are still other clothes under the overalls, before leaving home he changes into completely different clothes, puts on other shoes

he washes his hands there, well, without soap, but is that enough, because he eats there, there is no risk of poisoning?

"clothes under the suit, takes off at work, puts on other clothes and then goes home."

From this I conclude that there is nothing to pour on the child.

P.S. Yet, probably, he puts on clothes, but does not dress. You can wear what you can undress. You can put on what you can take off. Test meme: "Put on clothes, put on Nadezhda". And in order to understand the meaning, you can compare the meanings of verbs with the same prefixes - "to fasten" and "to cordon off".

Sorry for the offtopic, I couldn't resist.

I'm taking Stimulant. May I have a glass of wine?

Good afternoon!

I've been on Stimuloton for 3 weeks. It's my birthday today. Can I afford to drink 1 glass of dry red wine?

Thanks in advance for your reply!

If really only one glass, then you can drink. But in this case, it is better to stop taking the drug a couple of days before the event.

Rodent poisoning. How to determine if you have poisoned yourself?

Hello, this is an unusual question. I poisoned rodents on the site, laid 2 Daxofal tablets in different minks, did not know that this agent emits a deadly poisonous gas - phosphine. This is what I read on the Internet. Gas came from other holes, which were located under the windows of the kitchen, I smelled gas, did not attach any importance. There were children, after a while I began to pinch my tongue, then I got on the Internet and read all the information and was horrified. Week later. The right side of the neck hurts, not much. On the 3rd day, the child had an asymptomatic fever and a headache. Perhaps a coincidence, I feel good, only I exhausted myself. Whether to address to the doctor and to what. Everyone unanimously says, it's on the street, nothing will happen. I kindly ask for advice on this matter. It is possible to pass some kind of analysis to everyone. Thank you in advance.

Lara, check your liver enzymes, calcium levels, urea and creatinine.

What is the interval between taking furadonin and alcohol?

What is the interval between taking furadonin and alcohol? Thank you!

With the systemic intake of Furadonin, alcohol is prohibited!

After the end of treatment, alcoholic beverages can be consumed 12 hours after the last dose of the drug.

1. Is non-alcoholic beer (0.33 l or ~0.5 l per day for a total of up to a liter per week) also harmful during treatment with furadonin?

2. What fruits are harmful to eat during treatment with furadonin? For example, do pears contain an amount of alcohol that is unacceptable for this treatment? Thank you!

When can I take Paroxetine after drinking?

Hello, tell me, can I start taking paraxetine, after a week of hard drinking, I don’t use it for the second day, but PA has begun. Thank you.

If two days or more have passed since the moment of drinking, then you can take Paroxetine. Just do not forget that the dosage of the drug for PA should be calculated and controlled by the doctor!

Is it possible to tomatoes with cholecystitis?

1. Is it true that tomatoes are contraindicated in cholecystitis and generally harm the liver? Due to what?

2. Does rooibos contain (sedative) benzodiazepines? If so, in what quantities per liter of beer? Thank you!

Alexey, you can use tomatoes with cholecystitis. Usually, patients with such a diagnosis are recommended dietary table No. 5 and its varieties, which do not provide for restrictions on the use of tomatoes.

Tomatoes not only do not harm the liver, but also have an extremely beneficial effect on its condition. The choline contained in them (vitamin B4) is a natural hepatoprotector. The organic compound helps to regulate carbon metabolism, transport and metabolism of fats in the liver. A lack of choline can cause the deposition of fat in the liver and provoke the development of fatty liver.

Strong intoxication threatens addiction more?

The stronger the intoxication, the more the dose of alcohol that caused it leads to addiction? Thank you!

"More leads to dependence" - the wording is not very clear. Dependency either exists or it doesn't. It is probably not a mistake to answer this way - large doses of alcohol lead to the need for large doses.

Is homemade grape tincture toxic?

1. Frequent use of alcohol in small doses is more harmful in terms of the development of dependence, rare in larger ones. And will it be harmful from the point of view of the development of dependence if frequent doses are very small, equal to approximately 50 ml ~ 12% of alcohol (for example, wine) with the complete exclusion of other alcohol on these days:

1) once a week, along with periodic (~once every two weeks) consumption of ~30 ml of alcohol per day (not counting on 70 kg of body weight) strong or medium strength alcohol)?

2) several times a week, along with periodic (~once every two weeks) consumption of ~30 ml of alcohol per day (not counting on 70 kg of body weight with strong or medium strength alcohol)?

With all this, on the other days a day, try not to drink more than 30 ml of alcohol per 70 kg of body weight and / -18 weeks a year (divided into four periods) do not drink alcohol at all.

2. Is it harmful to eat watermelon seeds Thank you!

1. Any dose will be addictive with frequent use if it causes intoxication. Calculations like 1) and 2) are nonsense. Focus on whether you miss another regular dose.

2. I find it difficult to answer. I have never heard of poisoning with watermelon seeds.

Alexey, watermelon seeds contain up to 25% fatty oil, which includes linoleic, linolenic and palmitic acids. In terms of its physical and chemical properties, watermelon seed oil is similar to almond oil and may well replace it. It tastes like olive oil. It is used as a medicinal raw material to improve intestinal motility.

In my practice, there were patients who specifically ate watermelon seeds to get rid of constipation, and they really helped. In the countries of the East and Africa, for example, first and second courses are generally prepared with them. We do not eat them, although they do not bring harm. After all, watermelon belongs to the pumpkin family, the seeds of which we eat with pleasure.

In what cases are small doses of beer harmful?

1. What can an excess of rubidium lead to?

2. After heat treatment, onions retain the ability to increase the effect of alcohol toxicity?

3. When you talked about the safe dose of beer per week (with abstraction from alcohol and hop tranquilizers) equal to 2 liters (1 liter for fair-skinned, fair-haired and light-eyed) per 70 kg of body weight, you meant safety with in terms of allergies or burden on the body due to the processing of this amount of beer?

a) Is it harmful to consume non-alcoholic beer in excess of 2 liters (1 liter for light) per week for a long time (not at a time)?

4. Is elderberry toxic alone or in combination with alcohol? Thank you!

Savely, hello. What happened to the rectum?

On colonoscopy a month ago it was: the mucosa of the lower part of the sigma and rectum is edematous, hyperemic, granular, with multiple petechial erosions and hemorrhages, there is no vascular pattern, there is slight contact bleeding.

A couple of weeks have passed since the weekly course of Macmirror. Now the symptoms with the rectum have become much less, mucus and sometimes minor blood clots remain, but I would like to somehow speed up the healing process.

Are sea buckthorn candles enough?

p.s. I also noticed a strange thing: if I drink a lot of strong alcohol (400 grams), then the next day there are no symptoms at all from the rectum. What are these miracles?

When can I drink alcohol after giardiasis?

Stanislav, how long does the intestinal mucosa recover after giardiasis? I have a clinical picture of NUC in the form of proctosigmoiditis, but they found giardiasis. Now I am treating giardiasis. I'm going to stop taking macmirror soon. Interested in the issue of recovery time. There are different numbers on the Internet (from 2 weeks to 6 months!). If longer than a month, then tell me if you can drink occasionally, some kind of alcohol? If so, which one is better and in what quantities.

Thanks in advance!

Sasha, the recovery time depends on the type of mucosal defects. And alcohol, if you do not take it through the rectum, will not have time to reach the distal intestines. More importantly, it should be alcohol not in the form of beer or liqueurs of any kind.

Savely, according to my information, warm and hot water, on the contrary, lingers in the stomach and later enters the intestines. This is the basis of the recommendation to use warm water for washing the stomach.

Are gidazepam and thiotriazoline compatible?

Hello, are Gedazepam and Tetriozalin compatible?

Hello, if you meant "gidazepam" and "thiotriazoline", then yes, they are combined.

The man died from drinking. Could something be done?

Hello Anna! Excuse me for disturbing you. Apparently, I should have sought advice earlier in order to help my loved one. But it so happened that I found the article only now, when he had already died. My man had long bouts (two or three weeks). During this time, he hardly ate anything. We live in different cities and therefore I really could not help. He always had diarrhea after quitting drinking. He said that his stomach hurt and weakness, so to drown it out, he drank again. I have been drinking almost every month for the last six months! I couldn't resist and got rude! I decided that if he thought that I was leaving him, he would reconsider his life. He called again and begged for forgiveness, and I was categorical. He said that he had not been drinking for three days and he was still sick. And then he died! Tell me, is it my fault? The doctors diagnosed OSN. Answer me please! He was diagnosed with left ventricular hypertrophy.

Metallic taste in the mouth after the pharmaceutical block (disulfiram)

Hello! Tell me please,

it is clear that one can live with this, but a metallic taste in the mouth after intravenous administration of disulfiram drugs (coding), how long can this side effect last (a week, a month, six months) and what is it connected with?

Is it true that the blocked enzyme acetaldehyde dehydrogenase was created by evolution exclusively for the processing of ethanol, or is this enzyme still needed by the body for something else? And if I am 37 years old, I have already coded ten times and there was no such aftertaste before, does this mean that they used to inject a placebo before? And how would he keep more on the moral-volitional?

Konstantin, hello. Coding is a psychological impact, and the introduction of drugs that change the metabolism of ethanol is a pharmaceutical block. Taste in the mouth is a normal phenomenon associated with effects on chemoreceptors. It can last the entire or almost the entire duration of the drug.

Acetaldehyde is formed in the body not only as a result of the oxidation of alcohol, respectively, and its dehydrogenase is needed not only for the metabolization of ethanol.

There may be no taste from drugs. As for what they injected you with, I can’t judge in any way.

Thank you for the clarification. With the help of this information about methods and medicines on the site, I only recovered earlier after all the binges. A lot of people do not even think about how dangerous it is to drink heavily, do not know how to alleviate their condition and reduce the risk of various pathological conditions.

It doesn't seem to have that strong aftertaste anymore. I read that acetaldehyde is also found in tobacco smoke. And there is a predisposition to the development of Alzheimer's disease in the innate absence of the conversion of acetaldehyde to acetic acid. All the same, if the farm block is not as dangerous as a binge, but also not very useful either. Although narcologists-psychiatrists say that the pharm block is normal for the body, you should probably encode for the first time, and then, of course, somehow stretch out on the moral and strong-willed.

Does marijuana help with schizopathies?

Hello, I live with a diagnosis of schizopathy, this is especially aggravated during times of stress and emotional stress. I accidentally found a medicine for myself - marijuana, I smoked once every 3 months for a year and lived a normal life, now I don’t smoke for six months, I feel that I don’t have enough emotional relief, I go in for sports, I don’t lead an asocial lifestyle. Actually the question is: can marijuana really help with an illness, or is it just a lucky coincidence?

Anonymous, who cares?

It is not recommended to use marijuana with such a diagnosis - the disorder may worsen.

Most likely, periods of temporary relief are nothing more than sublimation.

Does alcohol affect periods or vice versa

Stanislav, good afternoon. Tell me, can alcohol somehow affect menstruation? Or menstruation for alcohol?

Stanislav, I think many people are interested in this. To date, a new procedure for the examination of drivers has been introduced. In the absence of ppm and in the presence of obvious signs of intoxication, the right to appoint blood and urine tests for substances included in the register of prohibited driving. Moreover, if they are not detected additionally for another toxic effect. What is this "extra"? Can the same analgesics and nootropics be recognized as such? Antipyretics also leave trace values ​​for a very long time, as they contain something similar to opiates.

What are trace values?

Some people have poor diction from birth. That is, if subjectively someone does not like the guards, in any case, can they be recognized as drunk for something? This is true? And how would not "sleep". This is who all evaluates the state. This is subjective, after all, and opens the way for possible corruption by law enforcement officers who can blackmail drivers. Are there any objective criteria, as in America, for example - put a finger to your nose, walk along the strip with your eyes closed, etc.

Where can I get clear information on all this?

Pavel maybe. With prolonged use, first the sensitivity of tissues to estrogen decreases, and then the production of estrogens itself. A little later, the synthesis of corpus luteum hormones also decreases.

The course of antibiotic treatment is quite long (at least 1-2 weeks), so many people have a question about their compatibility with alcohol. Many have heard that this combination is very dangerous, but it turns out - not always. There are several myths in which even some doctors can get confused.

Myths about the combination of alcohol and antibiotics

Alcohol weakens the effect of antibiotics

NO. In most cases, alcoholic beverages do not affect the therapeutic effect of this group of drugs. The only exception is therapy against the background of chronic alcohol use, which can occur with alcoholism. In this case, sometimes a more efficient breakdown of the active substance is possible, caused by an increase in the number of enzymes responsible for this. Although more often the opposite happens - the excretion of the antibiotic slows down, it accumulates and causes side effects.

But alcohol can interfere with recovery in other ways. After all, such factors in treatment as rest and nutrition are very important. Alcohol interferes with healthy sleep, interferes with the absorption of vital nutrients from food, increases blood sugar, and depletes the body. With chronic or sudden and heavy drinking, the immune system can suffer so much that any medications will be of little use.

Alcohol is not compatible with all antibiotics

NO. Most types of antibiotics that are most commonly prescribed do not interact with alcohol in any way. There are different theories why people have long believed otherwise. According to one of them, it was customary for doctors to punish patients in the treatment of sexually transmitted diseases by forbidding them to drink alcohol. There is also a version that this erroneous opinion has gone since the Second World War, when there was a large shortage of penicillin in North Africa, and it was extracted back from the urine of the treated wounded, and drinking beer interfered with this process. Therefore, doctors told the soldiers that it was dangerous to drink alcohol during treatment.

Drinking alcohol while taking antibiotics can cause serious side effects

YES. Although it is said above that there will be no problems with most antibacterial agents, there are also those during which it is strictly not recommended to drink alcohol during treatment. The fact is that some drugs are metabolized by the same or similar enzymes in the body as ethanol. Depending on how often and how much alcohol is consumed, the levels of these enzymes may decrease. As a result, a larger amount of the active substance of the drug and the breakdown product of alcohol (acetald) will accumulate in the body, which will cause an increase in side effects and a phenomenon such as a disulfiram-like reaction.

A disulfiram-like reaction is a complex of symptoms that develops against the background of accumulation in the body of the breakdown product of ethanol, which leads to intoxication. This principle is applied to the treatment of alcoholism with disulfiram, as a result, a lack of enzymes develops, which does not allow the body to break down and excrete alcohol normally - the patient becomes ill and cannot drink anymore. But in the case of antibiotics, this is a side effect that can occur when taking certain drugs.

Antibiotics in which alcohol is prohibited

The most famous among them is metronidazole. It is used in the treatment of various intestinal, dental, skin, lung infections. Many sources say that when combined therapy with this drug and alcohol intake, a disulfiram-like reaction may occur. But this claim is rather controversial, as studies conducted in 2003 found no evidence for this.

Later, another small study was conducted in which Finnish men took metronidazole for five days and they did not experience any side effects after drinking alcohol. Yet the authors of these trials acknowledge that this does not rule out the possibility that some people may be affected, and the rule of incompatibility between alcohol and the antibiotic metronidazole remains in place.

There is also a list of antibiotics, the use of which is more dangerous against the background of drinking alcohol. This includes primarily the group cephalosporins (cefotetan, ceftriaxone), as well as tinidazole, linezolid and erythromycin. Their interaction with alcohol is well known and doctors usually warn about it.

Table of antibiotics incompatible with alcohol

The name of antibiotics and preparations based on them	Effect when combined with alcohol	Recommendation
Sulfamethoxazole + trimethoprim (Bactrim, Septra)	Rapid heartbeat, tingling, warmth under the skin, redness, nausea and vomiting.
Metronidazole (Flagyl, vaginal gel and suppositories)	Disulfiram-like reaction: abdominal pain, nausea, vomiting, headaches, flushing of the face. The development of symptoms is also possible when using a vaginal cream.
Linezolid (Zyvox)	Increased risk of developing a hypertensive crisis (a dangerous increase in blood pressure).	Avoid drinking large amounts of alcohol.
Tinidazole (Tindamax)		Avoid drinking alcohol during treatment and 72 hours after it ends.
Cefotetan (Cefotetan)	Disulfiram-like reaction: abdominal pain, nausea, vomiting, headaches, flushing of the face.	Avoid alcohol intake.
Rifampicin (Rifadin)		Avoid drinking alcohol.
Isoniazid (Nidrazide)	Daily alcohol intake increases the risk of liver toxicity	Avoid drinking alcohol.
Cycloserine (Seromycin)	Increased risk of intoxication for the nervous system, convulsions are possible	Avoid drinking alcohol.
Ethionamide (Trakator, Thionide)	Increased risk of intoxication for the nervous system, psychosis possible	Avoid excessive alcohol consumption.
Antifungal
Voriconazole (Vfend, Voritab)	May increase or decrease the amount of the drug in the body	Avoid drinking alcohol.
Ketoconazole	Increased risk of liver toxicity and development of a disulfiram-like reaction (abdominal pain, nausea, vomiting, headaches, flushing of the face)	Avoid drinking alcohol.
Pyrazinamide	Increased risk of liver toxicity	Avoid daily alcohol consumption.
Thalidomide (Thalomid)	Increased risk of an additive effect (increased side effects), drowsiness, confusion.	Avoid or limit alcohol during treatment. Exercise caution when driving or operating machinery

Ethanol can be found not only in alcoholic beverages, but also in some medicines, such as cough syrup. Therefore, to prevent possible unpleasant consequences, the composition should be studied.

Antibiotics that can be combined with alcohol

Not all antibiotics have alcohol interaction effects, but avoiding alcohol when sick is important.

Despite the abundance of antiseptic and antimicrobial agents of the new generation, some types of drugs that have been used in medicine for many years still do not lose their relevance due to their high efficiency. We are talking about Dioxidine, which is widely used in surgical, otorhinolaryngological practice and some other medical fields.

Forms of release and composition

The drug is produced in the form of an ointment and a solution that contains the active substance - hydroxymethylquinoxaline dioxide.

Solution

Dioxidine solution is available in 10 and 20 ml ampoules, which are made of transparent glass. This form of the drug is used for external use, infusions and intracavitary administration. It may contain 5 and 10 mg of the active ingredient. Purified water is also used in the preparation of the medicinal solution.

Ointment

A 5% ointment intended for external application contains 50 mg of the active ingredient and is available in an aluminum tube or glass jar with a volume of 30 and 100 g. The preparation also includes macrogol, methylparaben and nipazole, which have an auxiliary effect.

Mechanism of action

The drug belongs to the group of antibacterial agents of synthetic origin. The main pharmacological action of the drug is antimicrobial. The substance that is part of Dioxidin is highly active against various types of bacteria, destroys the walls of their cells and leads to the death of infectious agents.

The drug can fight staphylococci, streptococci, proteus, Pseudomonas aeruginosa and Escherichia coli, causative agents of dysentery, some types of anaerobic bacteria, Klebsiella, Salmonella.

When treating skin lesions, this agent contributes to faster cleansing of the wound from necrotic masses and accelerates tissue healing.

Pharmacokinetics

When used externally, the drug is well absorbed through the skin, mucous membranes and wound surfaces into the blood. It is excreted from the body along with urine.

With intravenous administration, the maximum concentration of the substance is observed 1-2 hours after the penetration of the drug into the blood. The effect of the drug lasts for 4-6 hours. With prolonged use of the solution, there is no cumulative effect. Metabolites of the drug are excreted through the kidneys.

Indications for use

The drug can be used for external application and intracavitary administration. For each form of the drug there is a separate list of indications for use.

Outdoor use

Ointment and solution are used for the following purposes:

• treatment of infected damaged areas of the skin and burns, deep wounds in which necrotic contents are formed, and purulent cavities (skin abscess, phlegmon, osteomyelitis foci);
• disinfection of wounds after a surgical operation;
• treatment of skin diseases provoked by an increase in the activity of staphylococci and streptococci and accompanied by the formation of purulent pustules on the face and body.
• gargling with sore throat of a bacterial nature;
• local treatment of purulent infections of the respiratory system (sinusitis, inflammation of the adenoids), ear (otitis media);
• eye wash for conjunctivitis.

Intracavitary administration

Intracavitary injections of the solution are practiced in urology, gynecology, surgery and are prescribed for inflammatory processes of a purulent nature that develop in the abdominal and thoracic regions. These include:

• acute purulent cholecystitis;
• peritonitis;
• purulent inflammation of the serous membrane of the lungs (pleura);
• diseases of the urogenital sphere of an infectious nature, accompanied by the formation of necrotic exudate in the cavity of the reproductive and urinary organs.

The drug is also used for irrigation of the bladder in order to prevent the development of infectious processes and inflammatory diseases of the urinary tract after catheterization.

Contraindications

The drug is contraindicated for use in the presence of intolerance to the components of the drug and impaired adrenal function.

How to open an ampoule?

If the ampoule with a solution of Dioxidine has a narrowed part with a colored dot, then you need to place the container with the mark towards you, grab the vessel with your palm and, pressing the top of the ampoule with your thumb, break the lid.

To open a glass container with a solution, which has a pointed upper part without a mark, you need to use a file (it is attached to the preparation). It is necessary to place the file across the ampoule and make a small incision on the top of the glass. After that, it is necessary to wrap the neck of the container with a napkin, cloth or cotton wool and break it in the same way as described above.

How to use?

Features of the use of the drug depend on the dosage form and the nature of the course of the pathology. Therapy is carried out in the following ways:

• Intravenously, with the help of droppers. In septic conditions, a 0.5% agent is used, diluting it in an isotonic solution to obtain a concentration of the finished mixture of 0.1-0.2%. The maximum permitted single dose of the drug is 300 mg, the daily dose is 600 mg.
• Intracavitary introduction. For the treatment of purulent cavities, only 1% Dioxidine solution is used, which is injected undiluted into the infected area using a drainage tube, catheter or injection 1-2 times a day. Daily dosage - no more than 70 ml. Treatment course - 21 days. If necessary, therapy can be extended.
• Outdoor application. To treat deep wounds, you can use compresses or tampons, which are impregnated with a 0.5-1% Dioxidine solution and applied to the wound surface daily or every other day. Superficial infected skin lesions can be treated with ointment, applying it in a thin, even layer to the injured area.

With diabetes

In diabetes mellitus, the drug is most often used externally - for the treatment of trophic ulcers and other skin lesions resulting from metabolic disorders. You can use the tool in the way described above.

Into ear

With otitis, it is recommended to drip a 0.5% or 1% solution into the sore ear and nose, after cleaning the ear canal from dirt with cotton wool soaked in hydrogen peroxide. Dosage and duration of use is determined individually.

Into the nose

With purulent rhinitis in adults, a 0.5% and 1% solution can be instilled into the nasal passages (2-3 drops 2-3 times a day) or used for washing the nasal cavity. The sinuses must first be cleared of accumulated mucus.

With a complicated course of the infectious process in the respiratory system, the doctor may prescribe complex drops, which are a combination of Dioxidine and hormonal or vasoconstrictor drugs. For example, you can mix 5 ml of 1% Dioxidine solution, 5 ml of 0.1% Galazolin and 2 ml of 0.1% Dexamethasone.

For washing the nose, you can use an undiluted 0.5% solution or a preparation for oral administration with a dosage of the active substance of 10 mg, which should be mixed with saline in equal proportions.

How to use a nebulizer

The use of dioxidine in purulent rhinitis in children

Inhalations

For inhalations in a nebulizer, which are carried out with bacterial infectious diseases of the lower respiratory tract, a 1% Dioxidine solution is used. It must be diluted with sodium chloride in a ratio of 1:4. For 1 inhalation, 4 ml of the resulting product will be required. The duration of 1 session is 5-7 minutes.

Side effects

The introduction of the solution into the cavity or vein may be accompanied by the following side effects:

• increase in body temperature;
• chills;
• nausea, vomiting, diarrhea;
• involuntary muscle twitches;
• headache.

allergies

With intracavitary and intravenous administration of the drug, allergic skin reactions may occur. External application of the ointment and solution can provoke itching of the skin on the treated area and the development of peri-wound dermatitis.

Influence on the ability to control mechanisms

The drug can have a negative effect on the speed of psychomotor reactions and the ability to control mechanisms, therefore, during the period of treatment, you should stop driving a car and other vehicles.

special instructions

If the patient has impaired renal function, then the dosage of the antimicrobial drug is reduced.

Before using the solution, make sure that there is no sediment in it. If there are crystals in the liquid, you need to heat the ampoule with the medicine in a water bath. The disappearance of crystals means that the drug is suitable for use.

Alcohol compatibility

Since the drug belongs to the group of antibiotics, the use of this remedy is strictly forbidden to be combined with the intake of alcoholic beverages. Ethyl alcohol is not only able to neutralize the effect of the antimicrobial substance that is part of the drug, but also cause the development of severe adverse reactions.

Use during pregnancy and lactation

Due to the high toxicity of the drug and its ability to penetrate into the systemic circulation, it is contraindicated to use the drug during the period of bearing a child and breastfeeding.

Dosage of Dioxidin for children

Although manufacturers indicate in the instructions for use of the drug that the drug is contraindicated for use in childhood, pediatricians often prescribe this medication to young patients. Most often, a solution in the form of a solution is recommended to be instilled into the nose, ear, or used for inhalation. Ointment with hydroxymethylquinoxaline dioxide is almost never used in pediatric practice.

When conducting therapy, the minimum dosage should be chosen, since the medicinal substance is highly toxic. It is recommended to give preference to a 0.5% solution, 1 ml of which contains 5 mg of the active ingredient.

In the treatment of nasal diseases, 1-2 drops of the drug are instilled into each nasal passage. The procedure can be repeated 2-3 times a day.

When instilling the drug into the ear, you should first clean the ear canals from sulfur and other contaminants using a cotton swab soaked in hydrogen peroxide. After removing the sulfuric masses, you need to slightly tilt the child's head to one side and inject 2-3 drops of the Dioxidine solution into the ear with a pipette. With a bilateral course of the inflammatory process, manipulations must be repeated on the other ear. Before administering the drug, make sure that the eardrum is not perforated.

For inhalation, a 0.5% solution of Dioxidine should be mixed with sodium chloride in proportions of 1:2. For the procedure, you need 3-4 ml of the resulting liquid. The duration of inhalation should not exceed 3 minutes. The maximum allowable treatment period is 7 days.

Manufacturers of the drug indicate that it is not recommended to use Dioxidin for children, but pediatricians very often prescribe it.

Overdose

With prolonged use of high doses of the drug, acute adrenal insufficiency (hypocorticism) may develop. In this case, the drug is immediately stopped, drug therapy is carried out as soon as possible using hormonal agents.

Interaction with other drugs

The drug can be combined with other types of antibacterial agents.

Analogues

Analogues of an antibacterial drug include:

• Dioxicol (ointment);
• Dioxysept (solution for droppers and intracavitary administration);
• Voskopran (ointment dressing impregnated with Dioxidin ointment);
• Dichinoxide (powder for the preparation of ointment and injection solution);
• Dixin (solution).

Conditions for dispensing from a pharmacy

You can buy the drug, having a prescription written by your doctor.

Price for Dioxidine

For packaging a solution of 0.5-1% in a pharmacy, you will have to pay about 500 rubles. Some pharmacies sell ampoules by the piece (40-50 rubles per 1 pc.). A tube with ointment costs about 300 rubles.

Dioxidine storage conditions

Expiry date of the drug

The manufacturer indicates the following expiration dates of the drug:

• solution - 2 years;
• ointment - 3 years.

After opening, a glass container with liquid medicine can be stored in the refrigerator for no more than 7 days. This restriction does not apply to the ointment.