Diprosalik ointment hormonal or not. Diprosalik ointment: instructions for use. Release form, composition, action

1 gram ointments includes 500 mcg betamethasone and 30 mg salicylic acid . Additionally: 869.36 mg of vaseline and 100 mg of liquid paraffin.

1 gram lotion includes 500 mcg betamethasone and 20 mg salicylic acid . Optional: edetate disodium 0.3 mg, hypromellose 5 mg, isopropanol 392 mg, sodium hydroxide 5 mg, up to 1000 mg purified water.

Release form

The medicinal product Diprosalik is produced in the form of an external ointment in aluminum tubes of 30 grams, placed in a cardboard box and in the form of an external solution (lotion) in plastic dropper bottles of 30 ml, placed in a cardboard box.

pharmachologic effect

Local glucocorticoid, keratolytic, antimicrobial.

Pharmacodynamics and pharmacokinetics

Diprosalic is a local (external) combined therapeutic agent, the effectiveness of which is based on the action of its two active ingredients - betamethasone and salicylic acid .

Synthetic fluorinated glucocorticoid (steroid hormone) - betamethasone characterized by its high vasoconstrictive, antipruritic and anti-inflammatory efficacy.

Topically applied salicylic acid acts as an antiseptic and exhibits bacteriostatic, keratolytic and some fungicidal activity.

Indications for use

Ointment Diprosalik is prescribed to reduce inflammatory manifestations hyperkeratic and dry dermatoses sensitive to the effects glucocorticoids , including:

dyshidrosis ;
(including hand eczema, nummular eczema, eczematous dermatitis);
lichen planus ;
and other ichthyosis-like diseases.

Lotion Diprosalik is indicated for the treatment of negative external symptoms:

psoriasis ;
other dermatoses sensitive to glucocorticoids .

Contraindications

The use of ointment and lotion of the drug is absolutely contraindicated in:

personal hypersensitivity;
perioral dermatitis ;
pregnancy (for long-term use);
breastfeeding;
(rosacea);
trophic ulcerative skin lesions caused by venous insufficiency;
fungal , viral or bacterial skin infections (including , pyoderma, skin, simple and girdling , , blastomycosis, actinomycosis, sporotrichosis);
post-vaccination skin reactions;
skin tumors ( , skin cancer, , , epithelioma, , , xanthoma);
under the age of 2 years.

Relative contraindications (requiring careful use) are:

prolonged use;
age up to 12 years;
application to a large area of the skin or application under occlusive dressings .

Side effects

When using the drug, the occurrence of the following negative local phenomena was sometimes noted:

burning/itching;
skin cracks;
hypopigmentation ;
skin irritation;
prickly heat ;
dry skin;
folliculitis ;
skin maceration;
hypertrichosis ;
pain sensations;
perioral dermatitis;
purpura ;
contact allergic dermatitis ;
secondary infection;
telangiectasia ;
skin ;
local ;
striae .

When using high doses of the drug, using it for a long period of time and applying it under occlusive dressings, especially in children, the development of systemic side effects inherent in glucocorticoids is allowed, including:

inhibition of the functionality of the hypothalamic-pituitary-adrenal system;
growth retardation ;
formation Cushing's syndrome ;
insufficient weight gain;
increase .

Application instruction of Diprosalik (Way and dosage)

Ointment Diprosalik, instructions for use

Ointment Diprosalik is intended for external use. Treatment consists of applying a thin layer of ointment to completely cover problem areas of the skin. Most often, the therapeutic course requires twice the use of the drug per day (morning and evening), although some patients can achieve a maintenance effect with less frequent applications.

In the children's age category of 2-12 years, you can practice the local application of a thin layer of ointment on small affected areas of the skin. The course of such treatment should be limited to 7 days using the drug once, a maximum of twice in 24 hours.

Lotion Diprosalik, instructions for use

Lotion Diprosalik is also used exclusively externally. Apply the solution to the problem areas of the skin should be a thin layer twice a day (morning and evening), while trying to completely cover the entire affected area of the skin. For some patients, for a positive supporting effect, it is enough to carry out one application every 24 hours.

The duration of the therapeutic course is determined by the patient's tolerance to the active ingredients of the drug, the effectiveness of the treatment, as well as the presence and severity of side effects.

Overdose

Long-term local use of large doses of glucocorticoids can lead to suppression of the functionality of the pituitary-adrenal system, which can cause secondary insufficiency of adrenal function and phenomena hypercortisolism , including Cushing's syndrome . With prolonged local use of high dosages salicylic acid possible occurrence salicylates .

For the treatment of overdose with the active ingredients of Diprosalik, symptomatic therapy is carried out. Correct if necessary electrolyte imbalance . With chronic intoxication recommend phasing out glucocorticoids . To remove salicylates, alkalinization of urine (for example, taken orally sodium bicarbonate ) and assign forced diuresis .

Interaction

Interactions of Diprosalik with other therapeutic agents have not been identified.

Terms of sale

Diprosalic is available in pharmacies as an over-the-counter drug.

Storage conditions

The ambient storage temperature of both medicinal products should be limited to 25 °C.

Best before date

Ointment can be used for 5 years; lotion for 2 years.

special instructions

In case of development against the background of the use of Diprosalik hypersensitization or irritation , the ongoing treatment is stopped.

Accession of infection requires the appointment of appropriate therapy.

The systemic absorption of the active ingredients of Diprosalik will be higher when the ointment is applied under occlusive dressing , as well as when processing extensive surfaces of the body.

Even local use of glucocorticoids, especially in children, can lead to the formation of systemic side effects inherent in this group of drugs, including suppression of the functionality of the hypothalamic-pituitary-adrenal system.

With prolonged use of Diprosalik, the ongoing therapy should be discontinued gradually.

Diprosalic is not intended for use in ophthalmology (avoid contact with eyes).

Drug with anti-inflammatory and keratolytic action for external use

Active ingredients

Release form, composition and packaging

◊ Ointment for external use almost white, soft texture, homogeneous, does not contain visible particles.

Excipients: liquid paraffin - 100 mg, - 869.36 mg.

30 g - aluminum tubes (1) - packs of cardboard.

pharmachologic effect

Ointment Diprosalik is a combined preparation based on two active substances - betamethasone dipropionate and salicylic acid.

Betamethasone dipropionate - synthetic fluorinated corticosteroids - has an anti-inflammatory and vasoconstrictive effect.

When applied topically, salicylic acid has keratolytic, as well as bacteriostatic and some fungicidal effects.

Indications

Ointment Diprosalik is indicated to reduce the inflammatory manifestations of dry and hyperkeratic dermatoses sensitive to GCS therapy, including:

- psoriasis;

- neurodermatitis (chronic lichen simplex);

- lichen planus;

- eczema (including nummular eczema, eczema of the hands, eczematous dermatitis);

- dyshidrosis;

- seborrheic dermatitis of the scalp;

- ichthyosis and other ichthyosis-like conditions.

Contraindications

- an indication of hypersensitivity reactions to any of the components of the ointment in history.

Dosage

Ointment Diprosalik should be applied in a thin layer 2 times a day - in the morning and at night, completely covering the affected areas of the skin. In some patients, the maintenance effect can be achieved with less frequent applications.

Side effects

Adverse events that occurred with the use of local corticosteroids, included burning, itching, irritation, dry skin, folliculitis, hypertrichosis, acne-like rashes, hypopigmentation, perioral dermatitis, allergic contact dermatitis. The following events are more common with application of occlusive dressings: skin maceration, secondary infection, skin atrophy, striae and prickly heat.

Salicylic acid preparations can cause dermatitis.

If you experience adverse reactions that are not described in this leaflet, you should consult a doctor.

Overdose

Excessive and prolonged use of topical corticosteroids can cause depression of the function of the pituitary-adrenal system, leading to secondary adrenal insufficiency and hypercortisolism, including Cushing's syndrome.

Appropriate symptomatic treatment is indicated. Acute symptoms of hypercortisolism are usually reversible.

special instructions

If irritation or hypersensitization develops during the use of Diprosalic ointment, treatment should be discontinued.

In case of infection, appropriate therapy should be prescribed.

With topical application of corticosteroids, especially in children, there may be side effects characteristic of systemic corticosteroids, including inhibition of the function of the hypothalamic-pituitary-adrenal system.

Systemic absorption of corticosteroids and salicylic acid when applied topically will be higher when using occlusive dressings, as well as when used on large body surfaces.

With prolonged treatment with the drug, its cancellation is recommended to be carried out gradually.

Ointment Diprosalik is not intended for use in ophthalmology. Avoid contact with eyes and mucous membranes.

Use in pediatrics.

Children are more at risk of inhibition of the function of the hypothalamic-pituitary-adrenal system due to the use of local corticosteroids than adults, due to their greater ratio of body surface area to weight and, accordingly, increased absorption of the drug.

There have been reports of a decrease in the function of the hypothalamic-pituitary-adrenal system, Cushing's syndrome, growth retardation, insufficient weight gain and an increase in intracranial pressure in children receiving topical corticosteroids. Inhibition of the function of the hypothalamic-pituitary-adrenal system in children is determined by low levels of cortisol and lack of response to adrenocorticotropic hormone stimulation. An increase in intracranial pressure is manifested by a protrusion of the fontanel, headaches, bilateral edema of the optic nerve head.

Pregnancy and lactation

Due to the fact that the safety of the use of local corticosteroids in pregnant women has not been established, the appointment of this class of drugs during pregnancy is justified only if the expected benefit to the mother outweighs the potential risk to the fetus.

This class of drugs should not be used in high doses or for extended periods of time during pregnancy.

Since it has not yet been revealed whether the level of systemic absorption of local GCS is sufficient for the appearance of their detectable concentrations in mother's milk, either breastfeeding or the use of the drug should be stopped, taking into account how necessary it is for the mother.

Application in childhood

The drug can be used with caution in children over 2 years of age.

Terms of dispensing from pharmacies

The drug is approved for use as a means of OTC.

Terms and conditions of storage

Store in a dark place, out of the reach of children, at a temperature of 2 to 30°C.

Shelf life - 5 years from the date of production.

This drug belongs to the complex means for the treatment of skin lesions and dermatitis of various kinds. Ointment Diprosalik perfectly copes with psoriasis, eczema, all types of skin allergies and dermatitis. But this medicine is not at all as harmless as it might seem.

How does Diprosalic work?

Many are concerned about the question Diprosalik - hormonal ointment, or not. According to the instructions for use, Diprosalik ointment refers to, that is, artificially recreated adrenal hormones, the production of which is controlled by the pituitary gland. The main active ingredient of the drug in this case is betamethasone dipropionate. It relieves inflammation, has a calming and antihistamine effect. Thus, it is possible to fight skin itching and other manifestations of dry dermatitis. The second active substance of Diprosalik is salicylic acid, which produces a disinfecting effect, and also accelerates tissue regeneration.

Features of the use of Diprosalik ointment

The scope of the drug, as we have said, is wide. But Diprosalik ointment is most often used for. The drug helps to speed up the healing of affected areas of the skin and prevents the formation of new plaques. The agent is used twice a day, when the disease is in the active phase, after the drug begins to accumulate in the tissues, it can be smeared once a day and even less often.

The scheme of application of the drug is as follows:

Apply a thin layer of ointment to the affected area.
If necessary, apply a gauze bandage, bandage, or close the skin in another way.
Repeat the procedure 1-2 times a day depending on the effect. The course is from 1 week to a month. In particularly difficult cases, a longer regular use of Diprosalic is indicated to avoid relapse.

Skin health problems sometimes pretty spoil life not only as a visual defect, but also in the form of increasing physical discomfort. Ointments containing salicylic acid will help to fight back an unbearable disease. Such a drug is Diprosalik ointment.

Composition and active ingredients

1 gram of ointment contains:

salicylic acid - 30 mg (3%);
betamethasone dipropionate - 0.5 mg (0.05%);
as well as petroleum jelly and mineral oil as auxiliary components.

Pharmacological properties of Diprosalik ointment

Salicylic acid has an antifungal and disinfecting effect on the focus of the disease, it also softens the crusts, the stratum corneum of the skin. This ensures rapid rejection, separation of infected dead tissue, which reduces the process of constant self-infection. Thanks to these properties of salicylic acid, the desired recovery comes to the patient much faster.

Betamethasone dipropionate has vasoconstrictive properties, anti-inflammatory properties. It also removes unpleasant itching and discomfort in the affected area, which is very important during the treatment of skin diseases.

Release form and packaging

Diprosalic ointment in pharmacy chains looks like an ointment, which is placed in aluminum tubes. The volume of one tube is 30 grams.

Application

Ointment Diprosalik is used only externally.

Pharmacological group of the drug

Ointment Diprosalik refers to glucorticoids in combinations - steroid hormones. This type of hormones in the human body is responsible for the protective functions of cells: anti-inflammatory processes, anti-toxic and anti-shock, anti-allergic, etc. Localization of the drug Diprosalik on the affected skin area makes it possible to fully restore the healthy skin condition to the body. At the same time, it is faster and with a minimum of discomfort and painful symptoms.

Dosage and duration of treatment

As a rule, Diprosalic is applied to the skin twice a day (best in the morning and at bedtime). But the doctor will adjust the treatment individually. It is often found that the application requires application with less frequency. The duration is also discussed with the doctor. But if the treatment is independent, then they are guided by the sensations and the speed of the healing process.

Overdose of Diprosalic ointment

Cases of long-term treatment with an overdose are fraught with some difficulties: there may be a violation of the adrenal glands, their insufficiency and concomitant diseases with an excess of steroid hormones.

But doctors assure that all manifestations of an overdose are eliminated and reversible.

See also reviews Demalan - the drug is used for the disease demodicosis.

Indications for use

psoriasis;
neurodermatitis and mycotic manifestations in the form of lichen;
chronic atopic dermatitis;
eczema;
dyshidrosis;
ichthyosis;
seborrhea and others.

Contraindications

The use of Diprosalik is allowed for patients who do not have acute allergic reactions to the components of the drug. In case of hypersensitivity, the appearance of reactions to active or excipients, it is better to exclude Diprosalic from use.

For the treatment of skin diseases such as dermatitis, irritation and peeling, Belosalik ointment is used.

Application in pediatrics

Diprosalic is used in the treatment of diseases in children over the age of 2 years. But it is worth paying attention to the features of the application. Dosage at a young age should be minimal. It's all about the risk of susceptibility to problems with the adrenal glands in children. Based on the small area of the skin and the rapid absorption of the drug, it can be argued that the degree of overdose can occur much faster.

Also, do not forget that the adrenal glands can give subsequent complications to various organs of the child. That's why before treating children with Diprosalic, consult a pediatrician.

Pregnancy and lactation

Diprosalic is applicable, but in small doses and under medical supervision.

special instructions

If the patient during the treatment period feels discomfort, deterioration, irritation reactions, etc., then it is worth canceling the use of the drug.

At the end of the treatment course, you should not abruptly cancel the drug. You need to do this gradually reducing the dose and frequency of use.

Avoid getting Diprosalic on mucous membranes. The drug is intended only for the treatment of skin diseases. If there is contact, for example, with the eyes, immediately rinse them with plenty of running water.

Side effects of the drug

As a result of the use of Diprosalic, the following skin manifestations are possible: a rash similar to the effects of acne, itching, folliculitis, burning, prickly heat and other reactions.

Conditions of storage and purchase in pharmacies

Store the tube with ointment at a temperature of 2 to 30 degrees. Shelf life - 5 years. The release of the drug in pharmacies - without a prescription.

Diprosalik's analogs

Akriderm, Rederm ointments are also available on pharmacy shelves. These drugs have a similar pharmacological action.

This may be of interest! Bepanten in the fight against dermatitis and cracks.

Diprosalic is a drug that is part of the group of glucocorticosteroid drugs for external use, used in dermatological practice for the treatment of pathologies such as psoriasis, neurodermatitis and some others.

What is the composition and form of release of Diprosalik (ointment)?

The active substance Diprosalic is represented by betamethasone dipropionate, the content of which is 640 micrograms. The second active ingredient is salicylic acid, in the amount of 30 milligrams. Auxiliary drug compounds: liquid paraffin and petroleum jelly.

The drug is produced in the form of a white, soft, homogeneous ointment for external use, in aluminum tubes of 30 grams. Medicines are dispensed by pharmacies without a prescription.

What is the effect of Diprosalic (ointment)?

The active substance of the drug is included in the group of glucocorticosteroid hormonal agents, it is able to provide the following pharmacological effects: anti-inflammatory, antipruritic, anti-allergic. Antimicrobial, antifungal and keratolytic action due to the presence of salicylic acid.

The mechanism of action of betamethasone dipropionate is the ability to inhibit the activity of phospholipase and lead to a decrease in the amount of prostaglandins and leukotrienes - the main mediators of the inflammatory reaction.

This substance inhibits the migration of leukocytes into tissues due to a decrease in vascular permeability. It inhibits the reaction of antibody production, which dampens the autoimmune manifestations of diseases.

Salicylic acid has a moderate antimicrobial effect, which is expressed in the suppression of the activity of most microorganisms. The mechanism of its action is associated with damage to the bacterial cell membrane, with the blocking of most metabolic reactions in the body of a foreign agent, which quickly leads to its death.

The keratolytic effect is due to the suppression of keratinization processes, which is expressed in a decrease in the thickness of the stratum corneum in the affected area. Reducing the processes of keratinization helps to cleanse the skin, improves the penetration of the drug into the deeper layers of the epidermis and dermis.

The use of Diprosalic ointment within the recommended dosages rarely leads to systemic side effects, especially if the prescribed treatment times are followed. Part of the substance betamethasone dipropionate, which enters the bloodstream, is metabolized in the liver, excreted in the urine and stool.

What are the indications for use of Diprosalic (ointment)?

The use of the drug as a local remedy is indicated for use in the presence of the following diseases:

Psoriasis;
Atopic dermatitis, chronic course;
Lichen planus;
Neurodermatitis;
Eczema;
Seborrheic dermatitis;
Ichthyosis;
Dyshidrosis.

I remind you that the hormonal medicine must be prescribed by a specialist. In addition, the doctor, taking into account the state of health of the patient, must develop an effective and safe treatment regimen, as well as periodically monitor the correct use of the drug.

What are Diprosalic (ointment) contraindications for use?

The use of Diprosalik (ointment) instructions for use does not allow in the presence of the following conditions:

Age less than 2 years;
Individual intolerance to the drug or any of its components;
lactation period.

During pregnancy, the use of the drug is permissible if the benefit outweighs the potential risk to the fetus. However, the safety of using the ointment in this group of patients has not been determined. Special studies in this regard have not been carried out.

What is the use and dosage of Diprosalic (ointment)?

Ointment Diprosalik should be applied to the affected area of the skin with a frequency of up to two times a day. In some cases, more rare use is possible. The treatment strategy must be prescribed by the attending physician. The duration of therapy is determined by the doctor.

The ointment should be applied to previously cleansed skin. Excessive cornification of the skin can significantly reduce the effectiveness of use. The use of occlusive dressings is not allowed, as this may increase the adsorption (absorption) coefficient and lead to the development of severe side effects.

Overdose Diprosalik (ointment)

With prolonged and uncontrolled use, an overdose may develop, which is expressed in adrenal insufficiency and Cushing's syndrome. Treatment of such manifestations is symptomatic. The consequences of this condition are usually completely reversible.

What are the side effects of Diprosalic (ointment)?

The vast majority of side effects are local in nature: itching, burning, dry skin, manifestations of dermatitis, reduced pigmentation, atrophic changes, increased sweating, skin infections,

Systemic side effects: upper type obesity (mainly the shoulder girdle and chest), acne, increased blood pressure, increased bone fragility.

What are Diprosalic (ointment) analogs?

The drug Diprosalik can be replaced by the following drugs: Belosalik, Akriderm SK, Betnovate-S, Rederm, Betasal, Betaderm A, Diprosalik lotion, Belosalik lotion.

Conclusion

We have reviewed Diprosalik ointment, instructions for using this remedy. To reduce the likelihood of overdose and side effects, it is very important to follow the recommended time and prescribed dosage of the drug. With the development of undesirable consequences, you should immediately stop using the ointment and consult a doctor.