Claritin tablets instructions for use for children. Claritin for children - salvation from seasonal allergies. Release form and composition

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The instructions for use of Claritin do not contain precise information on the duration of one course of treatment. The duration of taking the drug is determined individually by an allergist; the usual course is from 3 to 10 days in case of severe exacerbation of allergies. For chronic allergic diseases, Claritin is taken for a course of 3 to 12 months, again as prescribed by a doctor.

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Claritin No. 10 tablets cost 300-350 rubles, Claritin No. 7 costs 230-270 rubles, Claritin No. 30 costs 550-600 rubles.

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You can take the antiallergic drug Claritin for 10-14 days. For allergic seasonal rhinitis, the course can be increased to 28 days.

Claritin for children

Allergic reactions of the child's body, in addition to skin rashes, are often accompanied by rhinitis. A stuffy nose prevents the child from breathing fully, and the skin rash causes itching. To eliminate these uncomfortable manifestations of allergies, as well as to prevent them from causing complications in the form of more severe diseases, such as bronchial asthma, experts prescribe antihistamines to children. Among them is claritin, which we will discuss in more detail below.

Composition and release form of Claritin

The main active ingredient of Claritin is loratadine. The anti-allergy drug Claritin is sold in pharmacies in the form of tablets or syrup. The tablets contain lactose and corn starch as additional substances.

Claritin syrup for children is a colorless liquid, sometimes with a yellowish tint. Due to the presence of flavoring and sucrose, it is sweet with a peach flavor, so children take it with pleasure.

When should you take Claritin?

Claritin is prescribed to children with the appearance of hives and an allergic reaction after an insect bite. The drug is also effective for children suffering from a hereditary predisposition to allergies or neurodermatitis.

The indication for the use of children's Claritin is allergic rhinitis. The drug effectively relieves the symptoms of a runny nose, relieving nasal congestion, itching, eliminating sneezing and burning eyes.

Based on the picture of the disease, specialists can prescribe the drug to children during the acute period of an infectious-inflammatory disease. By relieving tissue swelling, Claritin prevents the development of an allergic reaction in a sick child.

Claritin begins to have an antihistamine effect on the body 1 to 3 hours after taking the drug. Within 24 hours, it relieves tissue swelling and eliminates itching.

Claritin is taken once a day, regardless of the child’s food intake.

Syrup. The daily dose of syrup for children from 2 to 12 years old is 5 ml. If the child’s body weight exceeds 30 kg, the dosage of syrup is increased exactly twice. For children over 12 years of age, Claritin is prescribed in a dosage of 10 ml per day.

Pills. If the child does not refuse to take the tablets, then they are given half a tablet once a day to children from 2 to 12 years old. Children over 12 years of age and children whose body weight is more than 30 kg are prescribed one Claritin tablet per day.

Children suffering from impaired renal or liver function are recommended to take 10 ml of syrup or 1 tablet of Claritin once every two days.

How long can you take Claritin?

The duration of taking Claritin should be determined by a specialist.

In clinical settings, a persistent effect of claritin, without side effects, was observed for 28 days.

Contraindications to the use of Claritin

Children under 2 years of age should not take Claritin.

A contraindication to the use of the drug is intolerance to the components included in its composition. Children with kidney or liver failure can take Claritin under the supervision of a specialist.

Side effects of Claritin

In children, side effects while taking Claritin are extremely rare. Their main manifestations are:

In case of an overdose, a child must undergo gastric lavage and show it to a specialist who will prescribe maintenance therapy.

Claritin

Pharmacological properties of the drug Claritin

Pharmacodynamics. Claritin is an antihistamine, a selective blocker of peripheral H1-histamine receptors. Clinical studies have shown that improvement in the condition of most patients began within the first 30 minutes of using Claritin. The antiallergic effect develops during the first 30 minutes after taking the drug, reaches a maximum within 8-12 hours and lasts 24 hours. Loratadine and its metabolites do not penetrate the BBB. Claritin does not affect the central nervous system, does not exhibit anticholinergic or sedative effects, and does not affect the speed of psychomotor reactions. In a clinical study in which Claritin was used for 90 days at a dose that was 4 times the therapeutic dose, a clinically significant prolongation of the interval Q-T was not detected on the ECG.

Pharmacokinetics. Claritin is rapidly absorbed into the gastrointestinal tract. The time to reach the maximum concentration of loratadine in the blood plasma is 1-1.3 hours, and the time to reach the maximum concentration of the main metabolite, desloratadine, is approximately 2.5 hours. Eating increases the time to reach the maximum concentration of loratadine and desloratadine by 1 hour. The maximum concentration of loratadine and desloratadine is not affected by food intake. The maximum concentration increases in elderly patients, patients with chronic renal failure or alcoholic liver damage.

In almost all cases, the level of influence of metabolites is higher than the level of influence of the parent substance. Determinable concentrations appear in the blood plasma within 15 minutes after taking the drug orally. A comparative study of the use of Claritin syrup and tablets in adequate doses showed that the plasma concentration profile of desloratadine for both dosage forms is comparable.

When researching in vitro human liver microsomes, it was revealed that loratadine is metabolized into desloratadine mainly under the influence of cytochrome P450 3A4 (CYP 3A4) and to a lesser extent cytochrome P450 2D6 (CYP 3D6). The half-life is 8.4 hours for loratadine, 28 hours for its metabolites. About 27% of the administered dose is excreted in the urine during the first 24 hours. In the presence of ketoconazole, a CYP3A4 inhibitor, loratadine is converted to desloratadine primarily by CYP3D6. The half-life increases with alcoholic liver damage and does not change in the presence of chronic renal failure.

The pharmacokinetics of Claritin in children aged 1-2 years when prescribed a single dose of 2.5 mg does not differ from those in adults and older children.

Indications for use of the drug Claritin

Seasonal (polynosis) and year-round allergic rhinitis and allergic conjunctivitis - elimination of symptoms associated with these diseases: sneezing, itching of the nasal mucosa, rhinorrhea, burning sensation and itching of the eyes, lacrimation. Chronic idiopathic urticaria. Skin diseases of allergic origin.

Use of the drug Claritin

Adults and children ≥12 years old - 10 mg (1 tablet) 1 time per day;

children aged 2-12 years with a body weight of 30 kg - 10 mg (1 tablet) 1 time per day, with a body weight ≤30 kg - 5 mg (1/2 t tablet) 1 time per day;

children aged 1-2 years - 2.5 mg (1/4 t tablet) Claritin 1 time per day.

Adults and children aged ≥12 years - 10 mg (2 scoops - 10 ml syrup) 1 time per day;

children aged 2-12 years with body weight ≥30 kg - 10 mg (2 measuring spoons - 10 ml of syrup) 1 time per day, ≤30 kg - 5 mg (1 measuring spoon - 5 ml of syrup) 1 time per day;

children aged 1-2 years - 2.5 mg (1/2 measuring spoon - 2.5 ml of syrup) 1 time per day.

Contraindications to the use of the drug Claritin

Hypersensitivity (or idiosyncrasy) to any of the components of the drug.

Side effects of the drug Claritin

The incidence of side effects with Claritin is approximately the same as with placebo. Side effects such as fatigue, headache, drowsiness, dry mouth, gastrointestinal disorders (nausea, gastritis), allergic rash were noted. During the studies, isolated cases of alopecia, anaphylaxis, liver dysfunction, tachycardia and palpitations were observed.

Special instructions for the use of Claritin

Claritin does not have a clinically significant sedative effect when used in recommended doses (10 mg once daily). Claritin does not potentiate the effects of alcohol. At recommended doses, it does not affect the ability to drive vehicles or operate complex machinery.

Claritin should be discontinued at least 48 hours before skin diagnostic allergy tests are performed to prevent false results.

For patients with severe liver dysfunction, the initial dose should be reduced due to a possible decrease in the clearance of loratadine (an initial dose of 5 mg once daily or 10 mg every other day is recommended).

Use in children. The effectiveness and safety of Claritin in children under 1 year of age has not been proven. It should be noted that the pharmacokinetics of Claritin in children aged 1-2 years when prescribed a single dose of 2.5 mg does not differ from the pharmacokinetics of adults and older children.

Use during pregnancy and lactation. The safety of using the drug during pregnancy has not been established, therefore Claritin should be used only if the benefits of its use for the mother outweigh the potential risk to the fetus. Since loratadine is excreted in breast milk, a choice must be made between taking the drug and breastfeeding.

Drug interactions Claritin

When loratadine was taken simultaneously with ketoconazole, erythromycin, cimetidine, an increase in the concentration of loratadine in the blood plasma was noted, but this increase did not manifest itself clinically, including according to ECG data.

Claritin overdose, symptoms and treatment

In case of overdose, drowsiness, tachycardia and headache may occur. With a single dose of 160 mg, no side effects were noted (including ECG changes). In case of overdose, symptomatic and supportive treatment is recommended. Standard measures are recommended to remove unabsorbed drug from the stomach: gastric lavage, taking activated charcoal. Loratadine is not eliminated by hemodialysis. After emergency treatment, the patient should remain under medical supervision.

Storage conditions for the drug Claritin

In a dry place at a temperature not exceeding 25 °C.

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The drug Claritin is included in the category of antihistamine drugs and acts for about 24 hours, there is no drowsiness.
As a brief description, it should be noted that the active substance of Claritin is Loratadine. Produced by pharmaceutical companies in Belgium under the brand name Schering-Plough Labo. Prescribed to reduce the intensity of allergic reactions of various natures. ATX code – R06 AX13.
During the flowering seasons of plants, many people experience aggravation of various manifestations of allergies, for example, runny nose, headaches, sneezing, skin rashes, and difficulty breathing. There are many antihistamine drugs that can eliminate these symptoms, but at the same time they reduce performance, cause drowsiness, their duration of action is limited to a few hours, and there are a lot of side effects.
In this case, you should pay attention to Claritin, which relieves the symptoms of allergic reactions and also acts throughout the day without any negative effects on the general well-being of a person.
But before choosing this particular drug, you need to read the instructions for using Claritin in order to identify possible contraindications and study the rules for taking the medication.

Doses

Permissible doses of Claritin vary depending on the age category of the patient and the pharmacological form of the drug. For a positive effect, adults only need to take one tablet (10 mg) per day. Children under 12 years of age should calculate the dosage based on body weight. So, if the child’s weight is less than 30 kilograms, then it is recommended to replace the tablets with syrup. If you weigh more than 30 kilograms, the dosage is the same as for adults – 1 tablet. during the day.
For patients in the older age group, no dosage adjustment is required. But if you have functional liver pathologies, you need to take Claritin in minimal doses. For children, the permissible dose of the medication is 10 milligrams per day. For children under three years of age, allergy treatment with Claritin is contraindicated.

Release forms Claritin

For ease of administration, Claritin is available in several forms:
water-based syrup;
pills.
The tablet form is packaged in plates of 7 tablets, 10 tablets, 15 tablets. The package can contain 1-3 plates.
The syrup is available in glass bottles with a total volume of 60-120 milliliters. The kit includes a graduated syringe or a plastic measuring spoon for ease of taking the drug.

Analogues of Claritin

Pharmacological analogues of Claritin are drugs with the same active substance or drugs with a similar effect:
Alefin;
Loratadine;
Clargothyl;
Agistam;
Lorizan;
Erolyn;
Lorfast;
Pulmolor;
Loridin Rapid;
Eweik-Md;
Laurent ODT;
Loratadine-KR and others.

How to take Claritin?

In order for the drug to have a more effective therapeutic effect, it is enough to take it once a day. If the patient’s history shows signs of impaired functional properties of the liver, then it is recommended to take Claritin every other day, that is, after 24 hours.
It is better not to use an antihistamine during pregnancy. The exception is when the health of the mother is a priority over the risk to the fetus. You should refrain from eliminating allergies with Claritin while breastfeeding.
One of the main contraindications to the use of Claritin is individual intolerance to Loratadine and other substances that are part of the chemical composition of the drug.

Action of Claritin

The main effect of Claritin is to reduce the intensity and eliminate allergy symptoms. The patient notices the first signs of improvement half an hour after taking the tablet or syrup. Maximum effectiveness is achieved within 9-11 hours and the effect lasts about a day.
In case of severe allergic reactions, patients can take a double dose of Claritin, but this, instead of the desired relief of the condition, can lead to a drug overdose. An overdose is manifested by symptoms such as headaches, drowsiness, rapid pulse (tachycardia).
The first aid in this situation is gastric lavage, taking the required amount of activated carbon to absorb the drug (dosage - 1 tablet per 10 kilograms of the patient’s weight).
An overdose can develop not only as a result of exceeding the dosage of Claritin, but also when taking various antihistamines together. Therefore, you can combine medicinal substances only after consultation with your doctor.

Is it compatible with alcohol?

Combining medications with alcoholic beverages has never benefited anyone. Claritin is no exception. During studies, the effect of the drug on the nervous system was not noted, but some inhibition is possible. And additional exposure to alcohol can lead to significant depression of the central nervous system.
Also, the dose of Claritin for liver disease should be reduced. Alcohol-containing drinks have a destructive effect on the liver. The combination of these two factors can provoke a decrease in the functional properties of the liver. In this regard, the simultaneous use of alcohol and Claritin is unacceptable.

Does Claritin make you drowsy?

Loratadine, which is part of the chemical composition of Claritin, has little effect on the central nervous system. After taking the medicine, the patient does not feel additional drowsiness.
If drowsiness is associated specifically with the use of Claritin, then this is considered a side effect, which can be eliminated by replacing the drug with one of its analogues.

Claritin side effects

Treatment with Claritin sometimes causes side effects. For example, nausea, vomiting, inflammation of the gastric mucosa, headaches, dry mouth, fatigue, nervous conditions, and drowsiness may appear.
Rarely, but still, cases of alopecia - hair loss - have been reported.
What diseases does Claritin help with?
The antiallergic drug Claritin is prescribed to eliminate the clinical manifestations of allergies:
rhinoconjunctivitis;
itching in the nasal passages;
burning of the conjunctiva of the eyes;
sneezing;
lacrimation.
The drug is also used for skin lesions, for example, allergic urticaria.

Pharmacological properties

Patients who cope with seasonal exacerbations of allergies did not report any anticholinergic or strong sedative effects. With long-term treatment, no clinical changes in the functioning of internal organs and systems were observed. In addition, the drug does not exert additional stress on the cardiovascular system.
Laboratory studies of skin tests after taking 10 milligrams of Claritin showed that the antiallergic effect is achieved after approximately 2 hours, and peak effectiveness occurs within 12 hours. The drug is not addictive even after a month of regular use.

Who is Claritin tablets suitable for?

Anyone prone to seasonal allergy flare-ups is trying to find the perfect way to relieve symptoms with minimal impact on daily life. When the nose does not breathe, the head is cast iron and the whole body itches, the patient is looking for any remedy that will help alleviate this condition. It is in this case that many people choose Claritin.
The allergy does not go away in 1-2 days, so the chosen drug should not have side effects in the form of decreased concentration and performance, or drowsiness. Doctors do not advise car drivers to take many antihistamines. Unlike them, Claritin does not affect the nervous system and maintains clarity of thought and good spirits throughout the working day.

Results

Claritin is one of the safest medications with antihistamine properties. The medicine can be bought at your nearest pharmacy without a doctor's prescription.
The shelf life of the tablet form of Claritin is about 4 years, liquid syrup can be used for 3 years from the date of manufacture. This means that the drug can be carried with you at temperatures up to 25 degrees and used at the first manifestation of an allergy.

Compound

1 tablet contains the active substance: loratadine 10 mg;
excipients: lactose monohydrate 71.3 mg, corn starch 18 mg, magnesium stearate 0.7 mg.
Description
Oval-shaped tablets, white or almost white, containing no foreign inclusions, on one side there is a line mark, the trademark “Cup and Flask” and the number “10”, the other side is smooth.
Release form
Tablets 10 mg. 7, 10 or 15 tablets in blisters made of polyvinyl chloride and aluminum foil. 1, 2 or 3 blisters along with instructions for use in a cardboard box.

Pharmacological properties

Pharmacodynamics
Loratadine, the active substance of the drug Claritin®, is a tricyclic compound with a pronounced antihistamine effect and is a selective blocker of peripheral H1-histamine receptors. Has a quick and long-lasting antiallergic effect. The onset of action is within 30 minutes after taking the drug Claritin® orally. The antihistamine effect reaches its maximum after 8-12 hours from the onset of action and lasts more than 24 hours.
Loratadine does not penetrate the blood-brain barrier and has no effect on the central nervous system. Does not have a clinically significant anticholinergic or sedative effect, i.e. does not cause drowsiness and does not affect the speed of psychomotor reactions when used in recommended doses. Taking the drug Claritin® does not lead to prolongation of the QT interval on the ECG.
During long-term treatment, no clinically significant changes in vital signs, physical examination findings, laboratory results, or electrocardiography were observed.
Loratadine does not have significant selectivity for histamine H2 receptors. Does not inhibit norepinephrine reuptake and has virtually no effect on the cardiovascular system or pacemaker function.
Pharmacokinetics
Loratadine is quickly and well absorbed from the gastrointestinal tract. The time to reach the maximum concentration (Tmax) of loratadine in the blood plasma is 1-1.5 hours, and its active metabolite desloratadine is 1.5-3.7 hours. Eating food increases the time to reach maximum concentration (Tmax) of loratadine and desloratadine by approximately 1 hour, but does not affect the effectiveness of the drug. The maximum concentration (Cmax) of loratadine and desloratadine is independent of food intake. In patients with chronic kidney disease, the maximum concentration (Cmax) and area under the concentration-time curve (AUC) of loratadine and its active metabolite are increased compared to patients with normal renal function. The half-lives of loratadine and its active metabolite do not differ from those in healthy patients. In patients with alcoholic liver damage, the Cmax and AUC of loratadine are doubled compared to these values ​​in patients with normal liver function, while the pharmacokinetics of its active metabolite does not change significantly.
Loratadine has a high degree (97-99%), and its active metabolite has a moderate degree (73-76%) of binding to plasma proteins.
Loratadine is metabolized to desloratadine via the cytochrome P450 3A4 system and, to a lesser extent, the cytochrome P450 2D6 system. Excreted through the kidneys (approximately 40% of the oral dose) and intestines (approximately 42% of the oral dose) for more than 10 days, mainly in the form of conjugated metabolites. Approximately 27% of an oral dose is excreted through the kidneys within 24 hours of taking the drug. Less than 1% of the active substance is excreted unchanged through the kidneys within 24 hours after taking the drug.
The bioavailability of loratadine and its active metabolite is dose-dependent.
The pharmacokinetic profiles of loratadine and its active metabolite were comparable in adults and elderly healthy volunteers.
The half-life of loratadine ranges from 3 to 20 hours (average 8.4 hours), and that of desloratadine ranges from 8.8 to 92 hours (average 28 hours); in elderly patients, respectively, from 6.7 to 37 hours (average 18.2 hours) and from 11 to 39 hours (average 17.5 hours). The half-life increases with alcoholic liver damage (depending on the severity of the disease) and does not change in the presence of chronic renal failure.
Hemodialysis in patients with chronic renal failure does not affect the pharmacokinetics of loratadine and its active metabolite.

Indications for use

Seasonal (hay fever) and year-round allergic rhinitis and allergic conjunctivitis - elimination of symptoms associated with these diseases - sneezing, itching of the nasal mucosa, rhinorrhea, burning and itching sensation in the eyes, lacrimation.
Chronic idiopathic urticaria.

Contraindications

Intolerance or hypersensitivity to loratadine or any other component of the drug.
Children under 3 years of age and body weight less than 30 kg.
Breastfeeding period.
Patients with rare hereditary diseases (impaired galactose tolerance, Lapp lactase deficiency or glucose-galactose malabsorption).
Carefully
Severe liver dysfunction.
Pregnancy (see section “Use during pregnancy and breastfeeding”).
Use during pregnancy and breastfeeding
A large amount of data on the use of loratadine in pregnant women (more than 1000 cases analyzed) indicate that the drug has no effect on
the occurrence of malformations or feto- and neonatal toxicity of loratadine.
No reproductive toxicity was observed in animal studies.
As a precaution, it is advisable to avoid using the drug during pregnancy.
Loratadine and its active metabolite are released in breasts. If the drug is prescribed during breastfeeding, the issue of stopping breastfeeding should be decided.

Mode of application

Inside, regardless of meal time.
Adults, including the elderly, and adolescents over 12 years of age are recommended to take Claritin® at a dose of 10 mg (1 tablet) once a day.
When using the drug in elderly patients and in patients with chronic renal failure, no dose adjustment is required.
Children aged 3 to 12 years weighing more than 30 kg - 10 mg (1 tablet) 1 time per day.
For adults and children weighing more than 30 kg with severe liver dysfunction, the initial dose should be 10 mg (1 tablet) every other day.

Side effect

In clinical studies involving children aged 2 to 12 years, headache (2.7%), nervousness (2.3%), fatigue were observed more often than in the placebo group (dummies). (1 %).
In clinical studies in adults, adverse events observed more often than with placebo occurred in 2% of patients taking Claritin®. In adults, when using the drug Claritin®, headache (0.6%), drowsiness (1.2%), increased appetite (0.5%) and insomnia (0.1%) were observed more often than in the placebo group.
According to the World Health Organization (WHO), side effects are classified according to their frequency as follows: very often (≥ 1/10), often (≥ 1/100 to Information on side effects is provided based on the results of post-registration observations.
From the immune system: very rarely - allergic reactions (including angioedema, anaphylaxis).
From the nervous system: very rarely - dizziness, convulsions.
From the cardiovascular system: very rarely - tachycardia, palpitations.
From the digestive system: very rarely - dry mouth, nausea, gastritis.
From the liver and biliary tract: very rarely - liver dysfunction.
From the skin and subcutaneous tissues: very rarely - rash, alopecia.
General disorders: very rarely – fatigue.
Laboratory and instrumental data: frequency unknown - increase in body weight.
If any of these side effects get worse or you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Symptoms: drowsiness, tachycardia, headache.
In case of overdose, consult a doctor immediately.
Treatment: symptomatic and supportive therapy. It is possible to lavage the stomach and take adsorbents (crushed activated carbon with water).
Loratadine is not eliminated by hemodialysis. After emergency care is provided, it is necessary to continue monitoring the patient's condition.

Interaction

Eating does not affect the effectiveness of Claritin®.
The drug Claritin® does not enhance the effects of alcohol on the central nervous system.
Potential interactions may occur with all known inhibitors of CYP3A4 or CYP2D6, resulting in increased plasma levels of loratadine and an increased risk of side effects.
When loratadine was co-administered with ketoconazole and erythromycin (inhibitors of the CYP3A4 isoenzyme) or cimetidine (inhibitor of the CYP3A4 and CYP2D6 isoenzymes), an increase in the concentration of loratadine in plasma was observed, but this increase was not clinically significant, including according to electrocardiography.
When used simultaneously with drugs that inhibit hepatic metabolism, caution should be exercised.

special instructions

Taking Claritin® should be stopped 48 hours before skin testing, as antihistamines may interfere with diagnostic test results.
Impact on the ability to drive vehicles and operate machinery
No negative effect of the drug Claritin® on the ability to drive a car or perform other activities requiring increased concentration has been identified.
However, in very rare cases, some patients experience drowsiness while taking Claritin®, which may affect their ability to drive or operate machines.

Medicine has accumulated information about many diseases over thousands of years. Infections, injuries, tumors, heart and vascular diseases make up the bulk of pathologies found among people of different ages. However, there is a problem that awaits everyone. Regardless of gender and age, most people have encountered an acute and extremely unpleasant problem. Exotic types of foods, medications, pollen of flowering plants, insect poison - this is not a complete list of causes of allergies. Runny nose, itchy skin, allergic rash - Claritin will solve all these problems.

The mechanism of action of the drug Claritin for allergies

Allergy is a universal reaction of the body to any foreign substance or object. The immune system analyzes everything that gets inside - food, medicine, water. Anything that is unsafe is usually neutralized in the liver and excreted. There is also a more subtle mechanism for dealing with foreign objects. White blood cells, leukocytes, produce special substances called antibodies against them.

The antibody approaches the foreign substance individually, like a key to a lock. This ligament is quickly removed from the body. White cells have a kind of memory. They are able to recognize unsafe objects even many years after the first meeting. Immunity plays a huge role in the fight against objects such as bacteria, viruses, and malignant cells. However, the immune system sometimes malfunctions. Relatively harmless objects - new products, medicines - are perceived as foreign objects that must be destroyed. The body responds to their presence with a violent allergic reaction.

Allergies are the result of the influence of histamine

The immune system is not limited to simply eliminating such substances. Mast cells begin to act together with leukocytes. Inside them there is a large accumulation of the biologically active substance histamine. It is this that causes the well-known allergy phenomena:

Allergy - video

There is one immutable condition for the manifestation of the effects of histamine - the presence in tissues and organs of microscopic structures (receptors) that are capable of perceiving such a chemical signal. Histamine receptors are divided into two main types. H1 receptors are scattered throughout the body, especially in the brain and spinal cord. H2 receptors are mainly located in the digestive tract. They are not involved in the implementation of allergies. Their main role is to regulate the acidity of gastric juice.

Claritin stops the allergic reaction precisely at the stage of interaction between histamine and specific receptors. The active ingredient of the drug loratadine belongs to the second generation histamine receptor blockers.

Generations of antihistamines - table

The drug Claritin has almost no effect on type 2 histamine receptors. It selectively binds to H1 receptors. Histamine released from mast cells reaches the receptors, but cannot interact with it and transmit a chemical signal. The active substance loratadine occupies all the seats inside the receptors. Histamine is present next to them, but has no effect.

Antihistamines block the effects of histamine

Composition and release forms of the drug Claritin

Claritin (Latin name Claritine) contains loratadine as an active ingredient. The manufacturer produces the drug in two dosage forms - tablets and syrup. To make it convenient to take a microscopic dose of loratadine, the manufacturer adds other chemical components to it. They do not have any therapeutic effect, but make the treatment comfortable for adults and children.

Composition of Claritin tablets and syrup - table

Allergy medications at Dr. Komarovsky's school - video

Features of taking the drug

For adults, it is preferable to use Claritin in tablet form. For children, experts prescribe the drug in syrup form. The medicine is taken regardless of food intake. The dose and course of treatment are determined by a specialist depending on the severity of the allergic reaction. The drug is recommended to be taken with a sufficient amount of water. It is convenient to dose the syrup using a measuring spoon. The dose of the drug for children depends on body weight.

For children, Claritin is prescribed in syrup form.

Alcohol does not affect the effect of Claritin. In addition, during the treatment period you are allowed to drive a car and operate precision machinery. If a specialist has planned to conduct tests for sensitivity to various allergens, it is recommended to discontinue the drug two days in advance. Otherwise, the results will be unreliable. For liver diseases, when its ability to neutralize and remove drugs is reduced, the dose of Claritin is adjusted. The antihistamine effect of the drug reaches its maximum 8–12 hours after administration and lasts for more than a day. No significant interactions with other drugs have been identified with Claritin.

Indications for use

The drug Claritin is prescribed by specialists for the treatment of the following conditions:

• seasonal rhinitis. Most often, this disease occurs during the flowering period of various plants - trees, shrubs, weeds. Their pollen is an allergen that causes the formation of antibodies and the release of histamine. The drug eliminates lacrimation, sneezing, and nasal congestion;

  Very often, allergies occur in the form of rhinitis

• hives. This is one of the manifestations of allergies. In response to the action of an allergen, histamine is released by mast cells located inside the skin. As a result, a peculiar rash appears, consisting of many red flat spots. The appearance of the rash is accompanied by painful skin itching. Claritin, by blocking histamine receptors, causes the rash to fade and gradually disappear;
• allergic skin diseases. The presence of histamine in the skin does not always cause short-lived urticaria. The skin often suffers from the effects of household chemicals, medications, harmful production factors and the external environment. Painful itching, redness, formation of scratches and crusts - Claritin successfully copes with all these problems.

  Claritin is prescribed for skin diseases

Adverse reactions and contraindications

Any medicine has not only therapeutic but also undesirable effects to varying degrees. Each drug has them and can affect different aspects of the body’s functioning: the functioning of the brain, liver, kidneys, hematopoiesis. When studying Claritin, the following adverse reactions were recorded:

• headache;
• insomnia;
• drowsiness;
• nervousness;
• fatigue;
• increased appetite.

These types of unwanted effects are rare. The following adverse reactions to taking Claritin were even less common:

• dizziness;
• dry mouth;
• nausea;
• heartbeat.

Individual intolerance is a contraindication to the prescription of any medicine, including Claritin. In addition, the drug is prohibited from use in the following cases:

• age up to three years (for tablets);
• age up to two years (for syrup);
• hereditary dysfunction of enzymes that provide chemical transformations of various sugars - maltose, lactose, galactose. Such people have intolerance to milk and fermented milk products.

The drug is prescribed with caution for serious liver diseases - hepatitis, cirrhosis. These pathologies significantly reduce the organ’s ability to remove all foreign substances.

Use of Claritin during pregnancy

The effect of Claritin on the body of a pregnant woman and the fetus has not been studied. A specialist can prescribe the medicine if he is sure of the benefits for the mother. The active substance loratadine penetrates into the mother's vascular bed and from there enters breast milk. The need for treatment with this drug is a reason to transfer the baby to artificial feeding.

Analogue drugs

Claritin can be purchased at a pharmacy without a doctor's prescription. The price of tablets ranges from 155 to 655 rubles. The cost of Claritin syrup varies from 235 to 270 rubles. Antihistamines are produced by modern pharmaceutical companies in all price ranges. If it is necessary to replace Claritin with another drug, you can choose a medicine with a similar effect and release form.

Claritin analogues - table

Drug name	Active substance	Release form	Indications	Contraindications	Permissible age for prescribing the drug	Price
Kestin	Ebastine	syrup; pills.	Urticaria of various natures	pregnancy; breast-feeding; renal dysfunction.	12 years	From 180 rubles
Zyrtec	Cetirizine	drops; pills.	atopic dermatitis; hives.	pregnancy; breast-feeding; renal dysfunction.	1 year	From 193 rubles
Loratadine	Loratadine	powder; syrup; pills.	dermatitis.	pregnancy; breast-feeding.	2 years	From 13 rubles
Claridol	Loratadine	syrup; pills.	dermatitis.	pregnancy; breast-feeding.	2 years	From 65 rubles
Suprastin	Chloropyramine	pills; injection.	hives; skin itching; dermatitis.	pregnancy; breast-feeding; bronchial asthma.	3 years	From 105 rubles
Tavegil	Clemastine	pills; injection.	hives; skin itching; eczema.	pregnancy; breast-feeding.	1 year for solution; 6 years for tablets.	From 145 rubles
Fenkarol	Hifenadine	pills; injection.	hives; skin itching; eczema.	pregnancy; breast-feeding.	18 years	From 233 rubles
Rupafin	Rupatadin	Pills	Hives and itching of various natures	pregnancy; breast-feeding; renal dysfunction.	12 years	From 316 rubles
Lomilan	Loratadine	suspension; pills.	insect bites.	pregnancy; breast-feeding.	2 years for suspension; 3 years for tablets.	From 80 rubles
Loratadine	Loratadine	powder; syrup; pills.	dermatitis.	pregnancy; breast-feeding.	2 years for syrup; 3 years for tablets.	From 155 rubles
Clarotadine	Loratadine	pills; syrup.	hives; skin itching; dermatitis.	pregnancy; breast-feeding; renal dysfunction.	2 years	From 155 rubles
Ketotifen	Ketotifen	pills; syrup.	hives; skin itching; atopic dermatitis.	pregnancy; breast-feeding.	6 months for syrup; 3 years for tablets.	From 70 rubles

To eliminate allergic attacks, it is often recommended to use a drug such as Claritin. It can also be taken as a prophylactic agent to prevent relapses of those chronic diseases whose pathogenesis is based on allergic inflammation (bronchial asthma and the like).

The drug belongs to the group of antihistamines: it selectively blocks histamine receptors. The impact occurs at the level of cellular structures involved in the allergic reaction. Thanks to this, with the help of Claritin, you can relieve the symptoms of the disease without drowsiness and dry mucous membranes.

Release form, composition, dosage

Today the drug has two forms of release: syrup and tablets. Since Claritin for allergies is used not only for adults, but also for children, the syrup is prescribed specifically to small patients. It is much easier for them to take medications in liquid form. Tablets are more convenient for adults with allergies. Previously, the owners of the brand also produced drops and ointments (they were called l-Claritin).

If we talk about Claritin in the form of syrup, then it is an uncolored solution of a transparent color or with a slight yellowish tint. It has a homogeneous structure, without sediment or any impurities. This syrup is produced in dark glass bottles of 60 and 120 ml. A measuring spoon serves as an addition.

The tablets are oval, painted smooth white. On one side there is a separating line, and on the other there is an icon in the form of a vessel with the number 10. One package can contain 7, 10, 20 or 30 tablets.

In Claritin, regardless of its form, the active ingredient is Loratadine. One tablet contains 10 mg of Loratadine, and 1 ml of ready-made syrup contains 1 mg. Considering that the drug belongs to the antiallergic spectrum, the auxiliary components are hypoallergenic. Let's look at them in a table.

Therapeutic effect

The composition of Claritin works in several directions at once: it has an antihistamine, antiallergic and antipruritic effect. Such effects are directly related to blocking histamine receptors. The drug begins to act literally within half an hour. The duration of the therapeutic effect is 24 hours, regardless of whether syrup or tablets are used.

The nature of allergies and the human body’s reaction to something foreign is due to histamine. This is a special substance produced by cells upon contact with an allergen. When histamine binds to the appropriate receptors, a chain of reactions is started. They are the ones who lead to allergies. Under the influence of histamine, blood flow increases, the skin and mucous membranes become inflamed, severe itching and a number of other symptoms begin (runny nose, sneezing, coughing, watery eyes).

Thanks to Claritin, histamine receptors are blocked, which helps prevent the development of the reaction. Thanks to this blockage, histamine simply cannot be produced, and therefore there are no symptoms. Even if symptoms have already appeared, after the receptors are blocked, all discomfort quickly passes because there is no support at the cellular level.

Claritin is not able to pass through the blood-brain barrier, or bind to those histamine receptors that are located in the central nervous system. In this regard, the medicine does not have a sedative effect (it is expressed in drowsiness). The product acts selectively, selecting receptors responsible for the development of allergies. This is one of the differences between Claritin and drugs of the previous generation (Diphenhydramine, Suprastin) - they provoke drowsiness in patients.

Use of Claritin: indications

Claritin is an antiallergic drug. Its use is determined by the fight against the symptoms of this disease. Indications for use are as follows:

• Hay fever (seasonal runny nose of an allergic nature);
• Allergic rhinitis throughout the year;
• Allergic conjunctivitis of various types;
• Recurrent urticaria;
• Skin allergic diseases (eczema, dermatitis);
• Quincke's edema;
• Pseudo-allergy (to food);
• Allergic reaction to insect bites and other biological objects.

Thanks to the use of Claritin, you can get rid of a whole range of symptoms. Among them, experts identify the following:

• Swelling of the mucous membranes;
• Sneezing and coughing;
• Nasal congestion;
• Bronchospasm;
• lacrimation;
• Burning;
• Rashes.

Claritin: instructions

Tablets and syrup can be taken at any convenient time of the day, regardless of meals. Medicine in any form should be washed down with clean water. The dosage is determined by a specialist depending on age and the presence of concomitant pathologies. Children under 3 years old are given syrup, and at an older age you can drink Claritin in any convenient form of your choice.

Adolescents (from 12 years of age) and adult patients can take Claritin in tablet form once a day at a dosage of 10 mg. In this case, 10 ml of syrup corresponds to two measuring spoons (attached to the package) or one tablet. For those patients who suffer from liver or kidney failure or liver pathologies, caution should be exercised. To do this, start taking Claritin with one tablet or two tablespoons of syrup every other day. Other dosage regimens are also possible; before starting allergy treatment, it is better to consult with your doctor.

Attention: If allergy tests are indicated, then stop taking Claritin 48 hours before the procedure, otherwise the results will be false negative.

Overdose

Cases of Claritin overdose are recorded if the dose per day is more than 40 mg. The following symptoms develop:

• Drowsiness;
• Headache;
• Cardiopalmus.

You should be careful when choosing the dosage for children. Self-medication can be very dangerous for the health of a young patient. In children weighing less than 30 kg, the following symptoms develop in case of overdose:

• Cardiopalmus;
• Twisted mouth;
• Violation of muscle tone;
• Worm-like slow movements of the fingers;
• Torticollis;
• Twitching oak;
• Tick ​​and tremors;
• Swinging movements of limbs.

Treatment for an overdose of Claritin is aimed at eliminating such symptoms. It is necessary to remove the drug from the body as quickly as possible. This is done by gastric lavage with saline solution. Additionally, adsorbents are used: activated carbon is crushed and drunk with water.

Claritin: interactions with other drugs

Before using anti-allergy medication, you should consult an allergist. During a visit to a medical office, concomitant diseases and methods of their treatment must be discussed. Ketoconazole, Cimetidine, Erythromycin can increase the concentration of Claritin in the patient's blood. It does not have any clinical manifestations. This feature is taken into account during allergy treatment to avoid overdose.

Use of Claritin for children

The medicine can be given to children with allergies from the age of two. At the same time, up to 3 years - only in syrup form to avoid risks (the baby may simply choke). After the age of three, the drug is taken in any form. Because of this purpose, the syrup is called children's Claritin.

The dosage is determined taking into account the child’s body weight. It is best if the baby receives the daily dose at the same time. Typically the dosage is as follows:

• For children weighing more than 30 kg – 10 mg/day (1 tablet or 2 scoops of syrup);
• For children weighing up to 30 kg – 5 mg/day (half a tablet or 1 measuring spoon) or 10 mg every other day at the discretion of the attending physician.

The duration of the course is set individually. It depends on the speed of elimination of allergy manifestations. Treatment usually lasts from a couple of days to 14 days. At the same time, Claritin can be used for preventive purposes over a long period of time.

There are situations when treatment with Claritin is indicated for children under two years of age. This is due to the high effectiveness of the product. It quickly relieves the infant from all symptoms and has virtually no side effects on the central nervous system. Tablets are not given to infants, but the dosage is reduced:

• Up to 1 year – 1.5 ml/day;
• 1-2 years – 3 ml/day.

How to treat with Claritin during pregnancy and breastfeeding?

No studies have been conducted in pregnant women. During animal testing, no adverse reactions to the fetus were detected. It is believed that pregnant women can treat allergies and their manifestations with Claritin if the benefits of such therapy exceed the level of negative effects on the developing fetus.

Claritin tends to pass into breast milk. Moreover, its concentration is as high as that of the mother’s blood. If there is a need to take pills during lactation, then breastfeeding is temporarily abandoned. In this case, the baby is transferred to formula until the treatment is completed.

Side effects

Usually the drug is tolerated quite well by the body, regardless of the patient’s age. Side effects are extremely rare. However, the possibility of their occurrence should not be completely ruled out. However, reactions to the components of the drug differ in children and adults.

Side effects in childhood:

• Nervousness;
• Lethargy;
• Headache.

Side effects in adult patients:

• Headache;
• Drowsiness;
• Fatigue;
• Dry mouth;
• Gastritis;
• Nausea;
• Baldness;
• Rash;
• Tachycardia;
• Liver disorders at the functional level.

If any alarming symptoms occur, you should immediately consult a doctor. If you have urgent questions, you can also contact our specialist. He will give detailed advice of an individual nature. We recommend that you do not self-medicate so as not to complicate the course of the disease.

To eliminate allergic attacks, it is often recommended to use a drug such as Claritin.

It can also be taken as a prophylactic agent to prevent relapses of those chronic diseases whose pathogenesis is based on allergic inflammation (bronchial asthma and the like). The drug belongs to the group of antihistamines: it selectively blocks histamine receptors.

In this article we will look at why doctors prescribe Claritin, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Claritin can be read in the comments.

Composition and release form

Claritin is available in oval-shaped tablets in blisters of 7, 10 or 15 pieces (1-3 blisters) in a cardboard package. Detailed instructions are included with the drug.

• The tablets contain the active ingredient loratadine. Excipients: lactose monohydrate, magnesium stearate, corn starch.

Clinical and pharmacological group: histamine H1 receptor blocker. Antiallergic drug.

What does Claritin help with?

Indications for the use of Claritin are:

1. Skin pathologies of allergic origin.
2. Idiopathic urticaria (in particular, chronic).
3. Year-round and seasonal allergic conjunctivitis and rhinitis (to eliminate the symptoms associated with these pathologies - rhinorrhea, itching of the nasal mucosa, sneezing, lacrimation, itching and burning sensation in the eyes).

pharmachologic effect

The long-term and rapid antiallergic effect of Claritin is due to the properties of the active component - loratadine, which is a blocker of peripheral histamine H1 receptors.

An improvement in the condition is observed half an hour after taking Claritin, the maximum antihistamine effect occurs after 8-12 hours.
When used against the background of allergic conjunctivitis, year-round and seasonal allergic rhinitis, Claritin helps eliminate the symptoms caused by these diseases - itching of the nasal mucosa, sneezing, rhinorrhea, lacrimation, itching and burning sensation in the eyes.

Instructions for use

According to the instructions for use, Claritin is taken orally 1 time per day at any convenient time, regardless of meals.

• Adults (including elderly patients) and adolescents over the age of 12 years are recommended to take Claritin at a dose of 10 mg (1 tablet or 2 teaspoons / 10 ml / syrup) 1 time / day.
• For children aged 2 to 12 years, the dose of Claritin is recommended to be prescribed depending on body weight: for body weight less than 30 kg - 5 mg (1/2 tablet or 1 teaspoon /5 ml/ syrup) 1 time / day, for weight body 30 kg or more – 10 mg (1 tablet or 2 teaspoons /10 ml/ syrup) 1 time/day.
• For patients with impaired liver function or renal failure, the initial dose should be 10 mg (1 tablet or 2 teaspoons /10 ml/ syrup) every other day.

Antihistamines can distort the results of skin tests, so it is recommended to stop taking Claritin 48 hours before diagnostic skin tests.

Contraindications

The drug should not be used in the following cases:

1. Age up to 2 years (syrup);
2. Age up to 3 years (tablets);
3. Breastfeeding period;
4. Sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption - due to the presence of sucrose in the syrup;
5. Hypersensitivity to the active substance or auxiliary components of the drug;
6. Rare hereditary diseases (lapp lactase deficiency or glucose-galactose malabsorption, galactose intolerance disorders) are caused by the presence of lactose in the tablets.

Side effects

Most often, during treatment of children 2-12 years old, the development of headache, nervousness and fatigue was noted.
In adults, the following disorders were observed:

1. Nervous system: drowsiness or insomnia, headache;
2. Digestive system: increased appetite.

When conducting studies in the post-marketing period, in very rare cases, the development of disorders of certain body systems was noted:

1. Skin: alopecia;
2. Nervous system: fatigue, dizziness;
3. Cardiovascular system: tachycardia, palpitations;
4. Allergic reactions: anaphylaxis, rash;
5. Digestive system: liver dysfunction, dry mouth, gastrointestinal disorders (gastritis, nausea).

Since the effect of the drug may cause drowsiness in some patients, it is recommended to be careful when driving vehicles and machinery during therapy.

Pregnancy and lactation

The safety of loratadine during pregnancy has not been established. The use of Claritin during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus.

Loratadine and its active metabolite are excreted in breast milk, therefore, when prescribing the drug during lactation, the issue of stopping breastfeeding should be addressed.

Analogs

Analogues of the drug Claritin include:

• Loratadine;
• Claridol;
• Clarotadine;
• Lomilan;
• Lotharen;
• Clarfast;
• Clarifer.

Attention: the use of analogues must be agreed with the attending physician.

Prices

The average price of CLARITIN tablets in pharmacies (Moscow) is 230 rubles.

Conditions for dispensing from pharmacies

The drug is approved for use as a means of OTC.