Actovegin - instructions for use (injections, tablets, ointment, gel, cream). Why is Actovegin prescribed? When to give Actovegin injections in the morning or evening. Actovegin intravenously and intramuscularly: which is better? Actovegin for athletes: Can Actovegin be injected?

"Actovegin" is an injection drug that belongs to the pharmacological class of peptides. When patients find out that the main active component of the drug is an extract from the blood of calves, they are at least surprised. However, there is nothing strange in this composition - peptides have long established themselves as a class of effective and safe drugs for nervous, mental and cognitive disorders. How to inject Actovegin intramuscularly, what are the indications and contraindications for this, as well as what possible side effects are described in the article.

Composition and release form

The drug is available in the form of injection ampoules of 2, 5 and 10 ml. There are also other forms of release: gel, ointment, tablets, solution for infusion. Is it possible to inject Actovegin intramuscularly? Yes, this particular method is recognized as the most effective in terms of achieving a therapeutic effect. This fact does not negate the effectiveness of other forms of release of the drug, but when administered by injection, the drug enters directly into the blood, bypassing the organs of the gastrointestinal tract. The solution of the drug in ampoules is a clear or pale yellow liquid, without a distinct odor.

The solution is intended not only for intramuscular administration - intravenous injections can also be performed. How to inject Actovegin intramuscularly: to dilute or not? The instructions for use of the drug indicate that there is no such need: inside the ampoules the solution is already completely ready for administration. Simply open the ampoule, take the solution into the syringe and inject it.

Regardless of the volume of the ampoule (2, 5 or 10 ml), the concentration of the active substance is always the same - 40 mg per ml. Thus, ampoules with 2 ml of solution contain 80 mg of the active substance, ampoules with a volume of 5 ml - 200 mg, and ampoules with a volume of 10 ml - 400 mg, respectively.

The composition of the injection solution also contains (in addition to the main active ingredient - deproteinized hemoderivate) sodium chloride and water. Reviews from patients indicate that injection into the muscle, as a rule, is almost painless if the injection is performed correctly.

Therapeutic and pharmacological action of the drug

Regardless of the form of release, the drug has the same active ingredient - a deproteinized hemoderivative obtained from blood taken from healthy calves that received milk nutrition. This substance is obtained by special purification from large protein molecules - this process is called deproteinization. After it, a medium-sized aggregate by mass of active molecules of calf blood is formed, which, in turn, have the ability to “start” metabolism in almost any organ or tissue of the human body. The deproteinization process makes it possible to create a ratio of molecules of such a size that it becomes possible to avoid negative allergic reactions to the drug. Pharmacist-chemists were able to ensure that each milliliter of solution contained an equal amount of deproteinized hemoderivative, which was synthesized from the blood serum of dairy calves. All fractions have an equal mass of the active component and are capable of providing a therapeutic effect with the same and stable intensity for a wide variety of diseases and conditions.

In some instructions (depending on the form of release and time of packaging), the active component of the drug is called “Actovegin concentrate” - for brevity and in order not to scare off the patient who is uninitiated in the intricacies of pharmacology and chemistry. The drug has a number of contraindications; in rare cases, it is possible to develop some side effects (mainly neurological).

However, Actovegin (how to inject intramuscularly is described below) is most widely used in the treatment of neurological diseases. It successfully treats not only adults, but also children and adolescents. The drug is also used both as an independent remedy and as part of complex therapy in ophthalmology, cardiology, psychiatry, and dermatology.

Indications for use of the drug

The instructions for use indicate that the drug has the following indications for use in dermatology:

• increasing the rate of regeneration of the skin and surface of the mucous membranes due to various types of injuries (abrasions, cuts, burns, surgery, etc.);
• acceleration of tissue regeneration after burns and wounds;
• acceleration of healing of weeping wounds;
• mitigation of the reaction to radiation exposure;
• prevention of bedsore formation.

In neurology, the drug is most often used as intramuscular injections for the following diseases and pathologies:

• disorders of the brain due to vascular or metabolic abnormalities (traumatic brain injuries, strokes, blood flow disorders of other origins);
• impaired memory and attention due to vascular diseases of the central nervous system;
• as part of complex therapy for vascular disorders of a peripheral nature, their complications and as a prevention of their consequences (angiopathy, various kinds of trophic ulcers, endarteritis, etc.);
• polyneuropathy due to chronic alcoholism;
• delayed psycho-speech development;
• withdrawal and post-withdrawal syndrome in chronic alcoholism and drug addiction;
• restoration of cerebral circulation due to traumatic brain injury;
• recovery period after chronic stress, overwork, hypoxia, radiation, hypothermia, burns.

The overall effect after a course of injection administration of Actovegin can be described by the following points:

1. Regeneration is accelerated after any kind of injury, damage to blood vessels, skin, and tissues of internal organs.
2. The process of tissue respiration is activated, ensuring the rational use of oxygen by cells, which is delivered with blood to every part of the human body. Thanks to this, the consequences of circulatory disorders and hypoxia can be mitigated.
3. The process of using glucose by body cells that are in a state of hypoxia (oxygen starvation), as well as by tissues that, for one reason or another, experience metabolic exhaustion, is normalized.
4. The synthesis of protein, in particular collagen, fibers is normalized. Thanks to this, the process of cell division and restoration of all body tissues is accelerated. The process of cell division in blood vessels is also stimulated, which inevitably leads to normalization of blood supply to all organs and the brain.

Contraindications to the use of the drug

The instructions for use warn that, regardless of the form of release, the drug has the following contraindications for use:

• oliguria;
• decompensated heart failure (in particular, if the drug is used in the form of droppers);
• fluid retention of various etiologies;
• pulmonary edema;
• anuria.

Is it possible to inject Actovegin intramuscularly in the presence of chronic renal failure? The exact answer depends on the stage of the disease and the feasibility of using the drug. It is necessary to consult with the treating nephrologist. if the patient has chronic pyelonephritis in the acute stage, a consultation with a doctor is also necessary before the Actovegin course. Self-administration may in some cases worsen the patient's condition.

Can Actovegin be injected intramuscularly after consultation with a hepatologist if the patient has been diagnosed with cirrhosis? According to experts, sometimes the drug can improve the clinical picture, but only if the tests are not too critical (consultation with a doctor is necessary to make a conclusion about the advisability of a course of injections).

Possible side effects

How many days should Actovegin be injected intramuscularly to prevent an overdose and the development of side effects? Only the doctor who prescribed the drug can answer this question. Many people try to prescribe the drug and dosage for themselves, and as a result suffer from severe side effects. That is why the packaging contains information that the drug is sold strictly according to prescription.

The instructions for use warn that the following side effects may develop during injection (development is also possible when using gel, infusion or tablets):

• allergic reactions: swelling, urticaria, dermatitis, itching, increased sweating, hot flashes, hyperhidrosis, increased body temperature;
• from the gastrointestinal tract: nausea after administration, pain or pulling sensations in the epigastric region, indigestion, possible problems with the production of bile;
• from the cardiac system: pain in the heart, shortness of breath, hypotension, tachycardia, hypertension;
• from the central nervous system: headache, weakness, drowsiness, nausea, dizziness, tremors of the limbs, loss of consciousness; some patients, on the contrary, experience hyperactivity and problems concentrating during the course of injections (especially if the dosage was chosen incorrectly);
• from the skeletal and muscular system: pain of unknown etiology in the lumbar region, nagging pain in the joints, in bone tissue.

Is it possible to give Actovegin injections intramuscularly on your own?

This question worries many patients after they have been prescribed the drug. Let's try to answer the most common questions:

1. How to inject Actovegin intramuscularly - dilute it or not - before drawing the medicine into a syringe? No, you do not need to dilute the solution from the ampoule with anything. It is already ready for use, you just need to select it with a needle into the syringe and inject it.
2. Is it possible to inject 5 ml of Actovegin intramuscularly at a time? It happens that such a relatively large volume of an ampoule frightens patients. But there is no need to worry. It is possible to make such an injection, you just need to choose a large muscle for the injection. Optimally - the gluteus maximus. The injection should be placed in the upper outer region of the buttock, as if it were divided by two intersecting perpendicular lines.
3. How often can Actovegin be injected intramuscularly? The attending physician can answer this question based on the clinical picture of each individual patient. As a rule, injections are prescribed daily for 10 or 20 days. The exact duration of the course depends on the diagnosis, health status and individual characteristics of the patient.
4. "Actovegin" for yourself, on your own? It is quite possible to do this if you have the necessary skills. Many people can successfully administer the injection as skillfully and safely as nurses with years of experience performing such procedures. It is necessary to wipe the injection site with alcohol (where exactly to inject is shown in the figure below), then insert the needle with a sharp movement and, pressing on the piston, inject the drug. There should be no pain (except for slight discomfort when inserting a needle from a syringe).

Features of using the drug: time of day, alcohol intake, nutrition

At what time should Actovegin be injected intramuscularly - in the morning, at lunchtime or in the evening? It is optimal to perform the procedure in the first half of the day, since some patients develop side effects such as hyperactivity and agitation. Other people, on the contrary, suffer from drowsiness. If a person feels weak and wants to sleep after the injection, then it is permissible to give the injection in the second half of the day. Thus, the answer to the question of what time of day to inject Actovegin intramuscularly depends on the individual state of the body and the reaction to the drug.

During the course of treatment, the intake of alcoholic beverages should be completely avoided, since their effect can negate the therapeutic and pharmacological effect of the use of the drug. "Actovegin" promotes better nutrition of brain cells, while ethyl alcohol very actively destroys neurons and has a very strong toxic effect on the entire body as a whole. It’s not for nothing that Actovegin is often prescribed during withdrawal symptoms during remission in chronic alcoholism.

During the course of treatment, you should adhere to proper nutrition, which would not create obstacles in the recovery process of the body. An optimal balance in the diet of proteins, fats and carbohydrates should be maintained. This is especially important for those who take Actovegin to restore the functions of the nervous system and for the purpose of recovery from various tissue and dermatological pathologies.

Actovegin injections for children and adolescents

How to properly inject Actovegin intramuscularly for children? The drug is often prescribed by neurologists for delayed psycho-speech development. Only a doctor should prescribe a dosage for a child. In addition, it is almost always very difficult to give an injection to a child - therefore parents’ independent use of the drug is not encouraged. It is optimal to visit the treatment room with your child every day so that the injections are administered by a person with the necessary skills.

How long should Actovegin be injected intramuscularly into a child with delayed psycho-speech development? Usually the total duration of the course is 10 days. However, in some cases it may vary. Sometimes a neurologist, at his discretion, can reduce the daily dosage (for example, only 2 ml), but at the same time extend the total course time - 20 days instead of 10, and prescribe nootropics or anticonvulsants in parallel with the injections. You should definitely consult with your doctor about the specifics of treatment, and under no circumstances make an independent decision about the need for therapy for a child or adolescent.

How often should Actovegin be injected intramuscularly into a child? You should consult your doctor about this issue. Usually one injection is prescribed every 24 hours.

"Actovegin" can be administered intramuscularly or intravenously.

Patients with ischemic stroke or arterial angiopathy are administered as a dropper 20-50 ml of the drug, previously diluted in the infusion solution recommended by the doctor. As prescribed by the doctor, the drug can be administered either every other day or only two to three times a week.

How to inject Actovegin intramuscularly to patients with dermatological diseases? As a rule, it is prescribed 5 ml intramuscularly once a day for 10-20 days daily or two to three times a week for a month.

The drug can be administered intramuscularly quickly. If there is a need for intravenous administration, then you should be patient and achieve the slowest possible administration; it is not for nothing that the drug is used in droppers, significantly diluted with any medical solution. This is necessary so that too much concentration of the drug does not immediately enter the blood.

How many days should Actovegin be injected intramuscularly?

Depending on the clinical picture, the drug can be prescribed on a daily basis (as a rule, this method is used for neurological and psychiatric pathologies), or several times a week (usually this method is more effective for dermatological and cardiac diseases).

It is prohibited to decide on your own how many days to carry out therapy. The information provided in the instructions is for informational purposes only and is not a call for self-medication. Only after receiving an accurate diagnosis and determining concomitant diseases can the attending physician create the most effective course of treatment, which includes Actovegin injections.

Drug interactions when administered by injection

How to inject Actovegin intramuscularly so that it does not cause harm? Its interaction with other drugs (if any) should be taken into account.

When taken simultaneously with sedatives, drowsiness, weakness, and an inhibitory effect on the nervous system may increase.

When taken simultaneously with antidepressants, no precise data on the consequences have been identified, but it is recommended to carefully monitor the dosage of Actovegin and increase it gradually.

Since the interaction of peptides with most pharmacological drugs has not yet been fully studied, the instructions do not contain precise data on the possible consequences. Therefore, the drug is dispensed strictly according to a doctor’s prescription in Latin, while the dosage and duration of use, as well as a comprehensive course of drugs, must be discussed with a specialist.

The drug Actovegin is an extract of calf blood, which is free of protein. It is often used for prophylactic purposes or in treatment where ischemic and hypoxic damage occurs in organs and tissues, as well as complications caused by these damages.

Actovegin injections instructions

The instructions for the drug Actovegin provide information about its inherent properties of stimulating metabolism in tissue cells by increasing the speed of movement, accumulation, as well as through the utilization and consumption of glucose and oxygen. As a result, it becomes possible to increase the energy potential of the cell, which is vital in conditions where it is insufficient.

· In case of chronic fetal hypoxia, when there are functional and/or organic changes in the brain;

· In acute hypoxia;

· In case of birth trauma of the brain;

To ensure the greatest effectiveness of the drug for infants, treatment with Actovegin is carried out in the form of injections.

Actovegin injections price

The cost of the drug for one package, which contains 5 ampoules, is more than five hundred rubles. As a rule, 10 injections are prescribed. Based on this, we can conclude that the drug Actovegin for injections is quite expensive.

What is Actovegin prescribed for, why is it needed and what does it treat? Often, after consultation with the attending physician and examination, patients find this particular drug on the list of prescribed medications. The answer to the question largely depends on the form of release. This medicine is used intravenously, orally in the form of tablets, or externally in the form of an ointment, gel, or cream. More details about what Actovegin helps with, how it can affect the body and its functions, methods of using this medication and possible side effects are below.

Description, composition and release forms of the medicinal product

What is this widely known drug, which is used to treat a wide variety of pathologies? Actovegin's active ingredient is an extract from the blood of calves, which is deprived of protein through special processing. In scientific language, this substance is called deproteinized hemoderivative of calf blood plasma. The main effect of Actovegin is aimed at accelerating tissue regeneration.

In addition, Actovegin is able to protect against oxygen starvation and accelerate the healing of postoperative wounds. Since this drug affects the circulatory system, it is used to treat various pathologies of the neurology and cardiovascular system.

In some cases it is indicated for pregnant women. Why is Actovegin prescribed to women carrying a child? More often this is done for preventive purposes if the doctor notes a threat of developing placental insufficiency. But this drug can also be used as a therapeutic agent for severe circulatory disorders in a pregnant patient.

There are five pharmaceutical forms of this drug:

• pills;
• solution in ampoules for injection or infusion;
• cream, gel and ointment for external use.

The tablets are taken before meals, without chewing - just wash them down with still mineral water. The solution can be administered by injection intramuscularly or intravenously through a drip. If Actovegin is administered by infusion, it is first diluted in glucose or saline. External agents are used in the form of compresses, lotions, or simply to lubricate the affected areas of the skin. It is worth mentioning separately the use of Actovegin gel - it is intended for the treatment of various ophthalmological diseases.

When is the drug needed?

Since Actovegin affects the rate of blood circulation and metabolic processes in cells, it is used to treat diseases of a wide variety of organs. Considering that the active component of the drug is a natural substance, it can be prescribed to elderly patients, pregnant women and even newborns. The effect of this drug on the body of the expectant mother and her fetus has not yet been fully studied, but the obvious benefit, as practice shows, outweighs the probable risk.

The drug is prescribed intravenously, orally or externally in the following cases:

1. Ischemic stroke and its complications, leading to serious disorders of blood microcirculation in the brain.
2. Pathological changes in metabolic processes in brain tissue.
3. Injuries of the skull and brain, including birth injuries of a newborn.
4. Peripheral neuropathy due to diabetes mellitus.
5. Any peripheral circulatory disorders (varicose veins, angiopathy, endarteritis).
6. Poorly healing wounds and skin damage of any origin.
7. Trophic ulcers and bedsores.
8. Burns of any degree, including radiation.
9. Inflammatory processes of the cornea of ​​the eye, conjunctivitis.

This is why therapy with such a universal drug as Actovegin is needed.

Depending on the diagnosis made or suspected, the doctor may prescribe it orally or intravenously. If the patient's condition is severe, the drug will be administered intravenously. For long-term therapy, Actovegin tablets are used. To quickly heal wounds and scars, and treat corneal ulcers, gels or ointments are used for external use.

Prevention and treatment of oxygen starvation of tissues in pathologies of the cardiovascular system, in the fetus with placental insufficiency, the future of the mother, healing of bedsores, trophic ulcers, postoperative wounds and scars - this is what Actovegin is needed for.

Do pregnant women need the drug?

If a woman expecting a child has some problems with her health, blood pressure, hemoglobin level, Actovegin is often one of the first drugs on the prescription list. Why and why? Metabolic disorders in a pregnant woman's body invariably lead to changes in blood composition. The developing fetus does not receive in sufficient quantities all the substances it needs for normal growth and the formation of vital organs.

If a woman develops placental insufficiency during pregnancy, the child begins to suffer from hypoxia. Oxygen deficiency leads to a variety of and very serious consequences. First of all, brain cells and the nervous system begin to suffer. A child may be born with serious pathologies, which cannot always be cured.

The reasons for prescribing Actovegin, in addition to placental insufficiency, may be:

• placental abruption or placental previa;
• oxygen starvation of the fetus;
• gestosis in late pregnancy;
• delay in child development;
• varicose veins of the lower extremities;
• severe toxicosis and swelling;
• elevated blood glucose levels.

And also this drug is recommended for everyone who has already suffered involuntary miscarriages or frozen pregnancies. If a woman has already experienced difficulties with bearing a fetus, then she may be prescribed Actovegin tablets for preventive purposes.

How to use the drug externally

This medicine in the form of a gel or ointment deserves special attention. Ointments are available with different concentrations of the active substance. For severe skin lesions, severe burns, deep ulcers, Actovegin 20% concentration is used, the ointment is applied in a thick layer to the affected area of ​​the skin and covered with a bandage. As the patient's condition improves, they switch to a product with a lower concentration - 5%. If the wounds are healing, do not apply the ointment too thickly.

But, like any medicine, it should not be taken on its own, especially when it comes to treating pregnant women, lactating women and children.

What is important to know

Although Actovegin is a natural drug, not everyone can take it. It has its contraindications, and in some cases (usually in overdose or combination with other drugs) causes allergic reactions and other unwanted side effects.

It is prohibited to use Actovegin for the following pathologies:

• pulmonary edema;
• oliguria, urinary retention or complete absence;
• heart failure in the stage of decompensation.

If you are prone to allergies, you should use this drug with great caution. When using Actovegin tablets or solution, side effects may occur such as sweating, redness of the skin, rash and itching, increased body temperature, a feeling of a rush of blood to the face and upper torso. If eye gel was used, lacrimation, redness of the mucous membrane, and swelling of the eyelids may occur.

In such cases, you should immediately stop taking or administering the drug, rinse your eyes with clean water and consult a doctor. He will prescribe an antiallergic drug and select an analogue for further treatment.

It is strictly not recommended to take or discontinue the drug on your own, change its dosage or supplement it with other medications.

How to give an injection? Abstract to Actovegin: injections - intramuscular and intravenous. Droppers. Test on Actovegin. Injections or pills?

Before you do anything injections(or take tablets, or use ointments, gels, creams), you should study the instructions for the medicine given drug (in this case instructions for Actovegin).

After all, our body treats medicine as poison. The kidneys and liver try to remove the medicine as quickly as possible. The medicine is destroyed first in the digestive organs, then in the blood, which means that the medicine should be protected from destruction. But... and vice versa : medications have a destructive effect on our body.

The question arises: “How to administer the medicine, bypassing the liver, stomach...?” There is only one answer: by giving an injection!

The Frenchman Charles Pravat invented the syringe in 1853, which saved a lot of human lives. And this is truly a great invention!

So why is sometimes an injection better than a pill?

Firstly, the medicine, when administered parenterally, does not damage the stomach, acts stronger and faster.

A, Secondly, the injection can be given to a person who is unconscious.

The prick has a sister - it's drip, which is used when you need to administer a lot of medicine and it should only be entered gradually.

Actovegin solution injections are given intramuscularly, intravenously or in the form of infusions.

The ampoule is opened like an ampoule of any medicine. : place vertically with the tip up, lightly tap on the top of the ampoule (the solution flows down), the tip of the ampoule should be broken off(to avoid cutting yourself, it is better to take a piece of sterile cotton wool).
Using a syringe, draw solution from the ampoule (to avoid air ingress, you need to release a drop of solution while holding the syringe with the needle up).
Naturally, everything should be sterile ( you can see video ).

Actovegin injections / Instructions

The duration of treatment and dose are prescribed individually by the attending physician., depending on the disease and its severity.

Ischemic stroke : IV drip - 20-50 ml (from 800 to 2000 mg) of Actovegin solution for infusion, diluted in 200 -300 ml of 0.9% sodium chloride solution (or 5% dextrose solution), 1 week daily. Then they switch to intravenous drip administration from 10 to 20 ml (400-800 mg) for 14 days. The course of treatment ends with a transition to taking the tablet form of the drug Actovegin.

Diabetic polyneuropathy : IV 50 ml per day (2000 mg) Actovegin solution for 3 weeks. Then they switch to Actovegin tablets (3 times a day, 2-3 tablets) for 4-5 months. For b patients with diabetes mellitus the concentration of glucose in the solution for infusion of Actovegin with dextrose should be taken into account.

Wounds that are difficult to heal : IV 10 ml (400 mg) or 5 ml (200 mg) IM daily (or as prescribed by a doctor 3-4 times a week), Actovegin injections as an additional treatment to Actovegin for external use.

Radiation damage to mucous membranes and skin : V / c - 250 ml (1000 mg) between treatment sessions or before starting radiation therapy. And for another 14 days after the end of therapy with a further transition to Actovegin tablets (at least 4-5 months. 2-3 tables each three times a day).
The same treatment is carried out to prevent radiation damage to the skin and mucous membranes.
Or : five ml of IV medication solution - between therapy sessions.

Radiation cystitis : 10 ml is administered transurethrally along with antibiotics daily.

If we talk about the introduction of a solution Actovegin in the form of infusions, then 10-20 ml of the drug solution is dissolved in 200-300 ml of the main solution. Infusion rate up to 2 ml/ min.

Can everyone use Actovegin?

Contraindication, first of all, is increased sensitivity.
Therefore, in such a situation, treatment with Actovegin is suspended and antihistamine (and, if necessary, corticosteroid) treatment is carried out.

There are a number of diseases when Actovegin cannot be used (DSN, pulmonary edema, fluid retention, anuria, oliguria, severe hypertension).

Parenterally Act Ovegin injections can give anaphylactic reaction, so first make a test (no more than 2 ml IM). The test is done either by the doctor himself or by an experienced nurse!

Injections can be given both in the morning and in the evening.

Do not use Actovegin opaque solution!
After opening the bottle or ampouleActovegin solution cannot be stored, and then reuse it for injections: This will not only have no effect, but is simply dangerous to health.

When administering Actovegin parenterally, you need to use only a separate syringe: if solutions of other medications are prescribed simultaneously, each solution must be administered in a separate syringe, otherwise there is a risk of allergic reactions.

Keep ampoules should be kept in a dark place at room temperature (not higher than 25 ° C), in packaging, out of reach of children.
It is not recommended to store an open ampoule with Actovegin in the refrigerator; the medicine should be used immediately after opening the ampoule !

You may be interested in general instructions for using Actovegin, the compatibility of Actovegin with other medications,

Some drug manufacturers produce substances in a variety of forms. These are powders, capsules, ointments or gels, suppositories and solutions in ampoules for injections. The latter type differs in that it is used for more serious health problems. Actovegin in ampoules is also prescribed for diseases at a stage when tablets are less effective. How then is the drug taken? The following instructions will help you understand the rules for using Actovegin.

Instructions for use of Actovegin ampoules

In the RLS drug directory, Actovegin is listed as an antihypoxic drug. Its function is to improve the oxygen supply to tissues by increasing their metabolism. The solution itself is a clear or slightly yellowish liquid. The dosage in ampoules is 2.5 or 10 ml if they are intended for injection. To make infusions - droppers - you need 250 ml bottles.

Compound

• water for injections;
• sodium chloride;
• anhydrous glucose.

Why are Actovegin injections prescribed?

The drug is able to help transport and utilize glucose. Indications for the use of Actovegin include a wide range of diseases:

• metabolic disorders and problems with cerebral vessels;
• radiation damage to the skin and mucous membranes;
• ulcers of various origins;
• burns;
• bedsores;
• wounds that do not heal for a long time;
• diabetes mellitus and diabetic polyneuropathy;
• hypoxia of tissues and organs.

How to prick

The method of using Actovegin in ampoules can be intramuscular, intravenous or intra-arterial. The first method has a limit of 5 ml, because an overdose increases blood pressure. In addition, it is recommended to carry out trial administration of Actovegin to exclude the possibility of developing an allergic reaction. The standard dose is 10-20 ml intravenously or intra-arterially. The specific amount depends on the severity of the disease. After the first administration, switch to 5 ml per day intramuscularly or intravenously several times a week.

Intramuscularly

If the active substance is administered intramuscularly, i.e. in the form of injections, the dosage is 5 ml per day. The maximum number of procedures is limited to 20. Here is what you need to do to administer the drug to yourself or a patient:

1. wash your hands with soap;
2. warm up the ampoule with your hands;
3. place it vertically with the point up;
4. tap the ampoule to allow the liquid to drain to the bottom;
5. break off the tip of the ampoule;
6. use a syringe to draw the solution from the ampoule;
7. release a drop of liquid while holding the syringe with the needle up;
8. visually divide the buttock into 4 parts;
9. Wipe the upper outer square with alcohol;
10. stretch the skin;
11. insert the needle 3/4 at a right angle into the muscle;
12. administer Actovegin at a rate of 2 ml/min;
13. quickly remove the syringe;
14. Press the injection site with a tampon.

Intravenously

The drug is administered intravenously using injections or droppers. For infusions, a dosage of 10-50 ml is diluted in 200-300 ml of isotonic sodium chloride solution. The latter is often replaced with a 5% glucose solution. The main thing is to maintain an injection rate of 2 ml/min. The dosage of Actovegin depends on the disease:

• ischemic stroke - 20-50 ml for a week, and then 10-20 ml for another 2 weeks;
• vascular disorders of the brain – 5-20 ml daily for about 2 weeks;
• difficult-to-heal wounds – 10 ml up to 4 times a week.

To give an Actovegin injection intravenously, you must:

• prepare a syringe with medicine;
• pull the arm over the biceps with a tourniquet;
• work with your fist to swell the veins;
• lubricate the injection area with alcohol;
• insert a needle into a vein;
• remove the banner;
• administer medicine;
• take out the syringe and cover the injection site with cotton wool;
• bend your arm for 5 minutes.

Side effects

Among the side effects of Actovegin are the following:

• allergies in the form of swelling, rashes or itching;
• temperature increase;
• hot flashes;
• rapid pulse;
• arrhythmia;
• chest pain;
• dyspnea.

Contraindications

Actovegin also has limitations. The drug is prohibited under the following conditions:

• children under 3 years old;
• with kidney disease;
• with pulmonary edema;
• if heart failure is detected;
• in case of individual intolerance to injections;
• for problems with removing fluid from the body;
• with anuria.

Analogues of the drug

The drug "Solcoseryl" is completely identical. According to the description, this substitute is manufactured using the same technology and also contains deproteinized hemoderivative of calf blood. A special feature is that solcoseryl does not include a preservative, which increases the shelf life of Actovegin, but at the same time negatively affects the liver. Its price starts from 800 rubles. Here are a few more Actovegin analogues in ampoules:

1. "Cerebrolysin". New generation drug. Indicated for mental retardation in children, spinal cord and brain injuries, ischemic stroke. Price from 600 rub.
2. "Cortexin". A nootropic medicine that improves brain function, positively affecting attention, learning and memory. Price from 800 rub.

Features of the use of solution for injection

The first thing you should think about when treating with this medicine is alcohol. Actovegin and alcohol have completely opposite effects on the body. The drug improves cell respiration, but the harmful drink worsens it. For these reasons, you should not take alcohol together with Actovegin. When administered intravenously, it is recommended to monitor the water-salt balance to avoid swelling. If there are flakes floating in the ampoule, then it should not be used for injection.

In children

Ampoules as a form of release for children are used a little less frequently than tablets. This is due to the frequent occurrence of side effects and painful injections. If the doctor has prescribed a course of treatment with Actovegin, then children must undergo a trial administration to rule out allergies. The daily dosage is calculated as 0.4-0.5 ml per 1 kg of body weight intramuscularly.

During pregnancy

Actovegin is also useful for pregnant women - it has a positive effect on the blood supply to the placenta, reduces the risk of blood clots, which leads to a more stable supply of essential substances and oxygen to the fetus. Intravenous or intraarterial dosage ranges from 10 to 20 ml. After this course, switching to intramuscular injections, reducing the amount of Actovegin to 5 ml. Therapy consists of at least 10 administration sessions.

Actovegin represents drug with antihypoxic effect, activating the delivery and absorption of oxygen and glucose by cells of various organs and tissues. Due to the pronounced antihypoxic effect, Actovegin is also a universal metabolic accelerator in all organs and tissues. The drug is used topically (externally) to treat various wounds (burns, abrasions, cuts, ulcers, bedsores, etc.), as it accelerates the healing process of any tissue damage. In addition, Actovegin reduces the severity of disorders caused by insufficient blood supply to tissues and organs, and transforms vascular diseases caused by a sharp narrowing of their lumen into milder forms, and also improves memory and thinking. Accordingly, Actovegin is used systemically (in tablets and injections) to eliminate the consequences of stroke, traumatic brain injury, as well as to treat circulatory disorders in the brain and other organs and tissues.

Varieties, names, composition and release forms

Currently, Actovegin is available in the following dosage forms (which are also sometimes called varieties):

• Gel for external use;
• Ointment for external use;
• Cream for external use;
• Solution for infusion ("droppers") on dextrose in 250 ml bottles;
• Solution for infusion with 0.9% sodium chloride (saline) in 250 ml bottles;
• Solution for injection in ampoules of 2 ml, 5 ml and 10 ml;
• Tablets for oral administration.

Actovegin gel, cream, ointment and tablets do not have any other common simplified name. But forms for injection are often called simplified names in everyday life. Thus, solution for injection is often called "Actovegin ampoules", "Actovegin injections", and "Actovegin 5", "Actovegin 10". In the names "Actovegin 5" and "Actovegin 10" the numbers indicate the number of milliliters in the ampoule with the solution ready for administration.

All dosage forms of Actovegin contain as an active (active) component deproteinized hemoderivative obtained from blood collected from healthy calves fed exclusively with milk. Deproteinized hemoderivative is a product obtained from the blood of calves by purifying it from large protein molecules (deproteinization). As a result of deproteinization, a special set of small-in-mass biologically active molecules in the blood of calves is obtained, which are capable of activating metabolism in any organ and tissue. Moreover, this combination of active substances does not contain large protein molecules that can cause allergic reactions.

Deproteinized hemoderivative from the blood of calves is standardized according to the content of certain classes of biologically active substances. This means that chemists ensure that each fraction of the hemoderivative contains the same amount of biologically active substances, despite the fact that they are obtained from the blood of different animals. Accordingly, all fractions of the hemoderivative contain the same amount of active components and have the same intensity of therapeutic action.

The active component of Actovegin (deproteinized derivative) is often called "Actovegin concentrate".

Different dosage forms of Actovegin contain different amounts of the active component (deproteinized hemoderivative):

• Actovegin gel - contains 20 ml of hemoderivate (0.8 g in dried form) in 100 ml of gel, which corresponds to a 20% concentration of the active component.
• Actovegin ointment and cream - contain 5 ml of hemoderivative (0.2 g in dried form) in 100 ml of ointment or cream, which corresponds to 5% concentration of the active component.
• Solution for infusion in dextrose - contains 25 ml of hemoderivate (1 g in dried form) per 250 ml of ready-to-use solution, which corresponds to a concentration of the active component of 4 mg/ml or 10%.
• Solution for infusion in 0.9% sodium chloride - contains 25 ml (1 g dried) or 50 ml (2 g dried) hemoderivate per 250 ml ready-to-use solution, which corresponds to a concentration of the active component of 4 mg/ml ( 10%) or 8 mg/ml (20%).
• Solution for injection – contains 40 mg of dry hemoderivate per 1 ml (40 mg/ml). The solution is available in ampoules of 2 ml, 5 ml and 10 ml. Accordingly, ampoules with 2 ml of solution contain 80 mg of the active component, with 5 ml of solution - 200 mg and with 10 ml of solution - 400 mg.
• Tablets for oral administration contain 200 mg of dry hemoderivate.

All dosage forms of Actovegin (ointment, cream, gel, solutions for infusion, solutions for injection and tablets) are ready for use and do not require any preparation before use. This means that the ointment, gel or cream can be applied immediately after opening the package; the tablets can be taken without preparation. Solutions for infusion are administered intravenously ("dropper") without prior dilution and preparation, simply by placing the bottle in the system. And solutions for injection are also administered intramuscularly, intravenously or intraarterially without prior dilution, simply by selecting an ampoule with the required number of milliliters.

Hemoderivat, which is part of all dosage forms of Actovegin, contains sodium chloride in the form of sodium and chlorine ions, which are found in it because the blood of calves contains this salt, and it is not removed during deproteinization. That is, sodium chloride is not added specifically to the hemoderivative obtained from the blood of calves. Manufacturers indicate that the injection solution contains approximately 26.8 mg of sodium chloride per 1 ml. The sodium chloride content in other dosage forms of Actovegin is not indicated, as it is not calculated.

The injection solution in ampoules contains only sterile distilled water as an auxiliary component. The dextrose infusion solution contains distilled water, dextrose and sodium chloride as auxiliary components. A solution for infusion with 0.9% sodium chloride contains only sodium chloride and water as auxiliary components.

Actovegin tablets contain the following substances as auxiliary components:

• Mountain wax glycolate;
• Titanium dioxide;
• Diethyl phthalate;
• Dried gum arabic;
• Microcrystalline cellulose;
• Povidone K90 and K30;
• Sucrose;
• Magnesium stearate;
• Talc;
• Dye quinoline yellow aluminum varnish (E104);
• Hypromellose phthalate.

The composition of the auxiliary components of Actovegin gel, ointment and cream is shown in the table below:
Actovegin cream, ointment and gel are available in aluminum tubes of 20 g, 30 g, 50 g and 100 g. The cream and ointment are a homogeneous white mass. Actovegin gel is a transparent yellowish or colorless homogeneous mass.

Actovegin infusion solutions based on dextrose or 0.9% sodium chloride are clear, colorless or slightly yellow liquids that do not contain impurities. The solutions are produced in 250 ml transparent glass bottles, which are closed with a stopper and an aluminum cap with first opening control.

Actovegin injection solutions are available in ampoules of 2 ml, 5 ml or 10 ml. Sealed ampoules are placed in cardboard packaging of 5, 10, 15 or 25 pieces. The solutions themselves in ampoules are a clear, slightly yellow or colorless liquid with a small amount of floating particles.

Actovegin tablets are greenish-yellow, shiny, round, biconvex in shape. The tablets are packaged in dark glass bottles of 50 pieces.

Volume of Actovegin ampoules in ml

Actovegin solution in ampoules is intended for intravenous, intraarterial and intramuscular injections. The solution in ampoules is ready for use, so to make an injection you just need to open the ampoule and draw the medicine into the syringe.

Currently, the solution is available in ampoules of 2 ml, 5 ml and 10 ml. Moreover, ampoules of different volumes contain a solution with the same concentration of the active substance - 40 mg/ml, but the total content of the active component in ampoules of different volumes is different. Thus, ampoules with 2 ml of solution contain 80 mg of the active substance, ampoules of 5 ml - 200 mg, and ampoules of 10 ml - 400 mg, respectively.

Therapeutic effect

Actovegin is a universal stimulator of metabolism, which leads to a significant improvement in tissue nutrition and utilization of glucose from the blood for the needs of cells of all organs. In addition, Actovegin increases the resistance of cells of all organs and tissues to hypoxia, as a result of which, even under conditions of oxygen starvation, damage to cellular structures is minimally expressed. The general, cumulative effect of Actovegin is to enhance the production of energy molecules (ATP), necessary for the occurrence of all vital processes in the cells of any organ.

The general effect of Actovegin, which consists in improving energy metabolism and increasing resistance to hypoxia, at the level of various organs and tissues is manifested by the following therapeutic effects:

• Accelerates the healing of any tissue damage(wounds, cuts, cuts, abrasions, burns, ulcers, etc.) and restoration of their normal structure. That is, under the influence of Actovegin, any wounds heal easier and faster, and the scar forms small and unnoticeable.
• The process of tissue respiration is activated, which leads to a more complete and rational use of oxygen delivered with blood to the cells of all organs and tissues. Due to more complete use of oxygen, the negative consequences of insufficient blood supply to tissues are reduced.
• The process of glucose utilization by cells is stimulated in a state of oxygen starvation or metabolic exhaustion. This means that, on the one hand, the concentration of glucose in the blood decreases, and on the other, tissue hypoxia decreases due to the active use of glucose for tissue respiration.
• The synthesis of collagen fibers improves.
• The process of cell division is stimulated with their subsequent migration to areas where restoration of tissue integrity is necessary.
• Stimulates blood vessel growth, which leads to improved blood supply to tissues.

The effect of Actovegin in enhancing the utilization of glucose is very important for the brain, since its structures need this substance more than all other organs and tissues of the human body. After all, the brain uses mainly glucose to produce energy. Actovegin contains inositol phosphate oligosaccharides, the effect of which is similar to that of insulin. This means that under the influence of Actovegin, the transport of glucose into the tissues of the brain and other organs improves, and then this substance is quickly captured by cells and utilized for energy production. Thus, Actovegin improves energy exchange in the structures of the brain and meets its needs for glucose, thereby normalizing the functioning of all parts of the central nervous system and reducing the severity of cerebral insufficiency syndrome (dementia).

In addition, improved energy metabolism and increased utilization of glucose leads to a decrease in the severity of symptoms of circulatory disorders in any other tissues and organs.

Indications for use (Why is Actovegin prescribed?)

Various dosage forms of Actovegin are indicated for use in different diseases, so to avoid confusion, we will consider them separately.

Actovegin ointment, cream and gel - indications for use. All three dosage forms of Actovegin intended for external use (cream, gel and ointment) are indicated for use for the same following conditions:

• Acceleration of wound healing and inflammatory processes on the skin and mucous membranes (abrasions, cuts, scratches, burns, cracks);
• Improving tissue restoration after burns of any origin (hot water, steam, solar, etc.);
• Treatment of weeping skin ulcers of any origin (including varicose ulcers);
• Prevention and treatment of reactions to the effects of radiation exposure (including radiation therapy of tumors) on the skin and mucous membranes;
• Prevention and treatment of bedsores (only for Actovegin ointment and cream);
• For pre-treatment of wound surfaces before skin grafting during the treatment of extensive and severe burns (only for Actovegin gel).

Solutions for infusions and solution for injections (injections) Actovegin - indications for use. Solutions for infusions (“droppers”) and solutions for injections are indicated for use in the same following cases:

• Treatment of metabolic and vascular disorders of the brain (for example, ischemic stroke, consequences of traumatic brain injury, impaired blood flow in the structures of the brain, as well as dementia and disorders of memory, attention, ability to analyze due to vascular diseases of the central nervous system, etc.);
• Treatment of peripheral vascular disorders, as well as their consequences and complications (for example, trophic ulcers, angiopathy, endarteritis, etc.);
• Treatment of diabetic polyneuropathy;
• Healing of wounds of the skin and mucous membranes of any nature and origin (for example, abrasions, cuts, incisions, burns, bedsores, ulcers, etc.);
• Prevention and treatment of lesions of the skin and mucous membranes due to exposure to radiation, including radiation therapy of malignant tumors;
• Treatment of thermal and chemical burns (only for injection solutions);

Actovegin tablets – indications for use. The tablets are indicated for use in the treatment of the following conditions or diseases:

• As part of complex therapy for metabolic and vascular diseases of the brain (for example, cerebrovascular insufficiency, traumatic brain injury, as well as dementia due to vascular and metabolic disorders);
• Treatment of peripheral vascular disorders and their complications (trophic ulcers, angiopathy);
• Diabetic polyneuropathy;
• Hypoxia of organs and tissues of any origin (this indication is approved only in the Republic of Kazakhstan).

Instructions for use

Actovegin ointment, cream and gel - instructions for use

Various dosage forms of Actovegin for external use (gel, cream and ointment) are used for the same conditions, but at different stages of these diseases. This is due to various auxiliary components that give different properties to the gel, ointment and cream. Therefore, gel, cream and ointment provide scarring of wounds at different stages of healing with different types of wound surfaces.

The choice of Actovegin gel, cream or ointment and the features of their use for different types of wounds

Actovegin gel does not contain fat, as a result of which it is easily washed off and promotes the formation of granulations (the initial stage of healing) with simultaneous drying of wet discharge (exudate) from the wound surface. Therefore, it is advisable to use the gel for the treatment of weeping wounds with copious discharge or at the first stage of treatment of any wet wound surfaces until they become covered with granulations and become dry.

Actovegin cream contains macrogols, which form a light film on the surface of the wound that binds discharge from the wound. This dosage form is optimally used for the treatment of wet wounds with moderate discharge or for the treatment of dry wound surfaces with thin growing skin.

Actovegin ointment contains paraffin, due to which the product forms a protective film on the surface of the wound. Therefore, the ointment is optimal for long-term treatment of dry wounds without discharge or already dried wound surfaces.

In general, Actovegin gel, cream and ointment are recommended to be used in combination as part of a three-step therapy. At the first stage, when the surface of the wound is wet and there is copious discharge, a gel should be used. Then, when the wound dries and the first granulations (crusts) form on it, you should switch to using Actovegin cream and use it until the wound surface is covered with thin skin. Next, until the integrity of the skin is completely restored, Actovegin ointment should be used. In principle, after the wound stops getting wet and becomes dry, you can use either cream or Actovegin ointment until complete healing, without changing them sequentially.

• If the wound is wet with copious discharge, then the gel should be used until the wound surface dries. When the wound dries, you need to switch to using a cream or ointment.
• If the wound is moderately wet, the discharge is scanty or moderate, then you should use a cream, and after the wound surface has completely dried, switch to using an ointment.
• If the wound is dry, without discharge, then ointment should be used.

Rules for treating wounds with Actovegin gel, cream and ointment

There are differences in the use of gel, cream and ointment for treating various wounds and ulcers on the skin. Therefore, in the text below, the term “wound” will mean any damage to the skin, with the exception of ulcers. And, accordingly, we will separately describe the use of gel, cream and ointment for the treatment of wounds and ulcers.

The gel is used to treat weeping wounds with copious discharge. Actovegin gel is applied exclusively to a previously cleaned wound (except for cases of treatment of ulcers), from which all dead tissue, pus, exudate, etc. have been removed. It is necessary to clean the wound before applying Actovegin gel because the drug does not contain antimicrobial components and is not able to suppress the onset of the infectious process. Therefore, to avoid infection of the wound, it should be washed with an antiseptic solution (for example, hydrogen peroxide, chlorhexidine, etc.) before treatment with Actovegin healing gel.

On wounds with liquid discharge (except ulcers), the gel is applied in a thin layer 2 - 3 times a day. In this case, the wound does not need to be covered with a bandage if there is no risk of infection and additional injury during the day. If the wound may be contaminated, then it is better, after applying Actovegin gel, to cover it with a regular gauze bandage and change it 2-3 times a day. The gel is applied until the wound becomes dry and granulations (an uneven surface at the bottom of the wound, indicating the beginning of the healing process) appear on its surface. Moreover, if part of the wound is covered with granulations, then they begin to treat it with Actovegin cream, and the wet areas continue to be lubricated with gel. Since granulations most often form from the edges of the wound, after their formation, the perimeter of the wound surface is lubricated with cream, and the center with gel. Accordingly, as the area of ​​granulation increases, the area treated with cream increases and the area treated with gel decreases. When the entire wound becomes dry, it is lubricated only with cream. Thus, both gel and cream can be applied to the surface of the same wound, but to different areas.

However, if ulcers are being treated, then their surface does not need to be washed with an antiseptic solution, but Actovegin gel is immediately applied in a thick layer and covered with a gauze bandage soaked in Actovegin ointment. This dressing is changed once a day, but if the ulcer is too wet and the discharge is copious, then treatment is carried out more often: 2 - 4 times a day. In case of very wet ulcers, the bandage is changed as the bandage gets wet. In this case, each time a thick layer of Actovegin gel is applied to the ulcer, and the defect is covered with a gauze bandage soaked in Actovegin cream. When the surface of the ulcer stops getting wet, it begins to be treated with Actovegin ointment 1 - 2 times a day, until the defect is completely healed.

Actovegin cream is used to treat wounds with a small amount of discharge or dry wound surfaces. The cream is applied in a thin layer to the surface of the wounds 2 – 3 times a day. A bandage is applied to the wound if there is a risk of smearing Actovegin cream. The cream is usually used until the wound is covered with a layer of thick granulation (thin skin), after which they switch to using Actovegin ointment, which is used to treat the defect until it is completely healed. The cream should be applied at least twice a day.

Actovegin ointment is applied only to dry wounds or to wounds covered with thick granulation (thin skin), in a thin layer 2 - 3 times a day. Before using the ointment, the wound must be washed with water and treated with an antiseptic solution, for example, hydrogen peroxide or chlorhexidine. A regular gauze bandage can be applied over the ointment if there is a risk of the drug being smeared from the skin. Actovegin ointment is used until the wound is completely healed or until a durable scar forms. The product should be used at least twice a day.

In general, it is obvious that Actovegin gel, cream and ointment are used in stages to treat wounds at various stages of healing. At the first stage, when the wound is wet, with discharge, a gel is applied. Then, in the second stage, when the first granulations appear, a cream is used. And then, at the third stage, after the formation of a thin skin, the wound is lubricated with ointment until the integrity of the skin is completely restored. However, if for some reason it is not possible to treat wounds sequentially with gel, cream and ointment, then you can use only one Actovegin product, starting to use it at the appropriate stage from which it is recommended. For example, Actovegin gel can be used at any stage of wound healing. Actovegin cream begins to be used from the moment the wound dries, it can be used until the defect is completely healed. Actovegin ointment is used from the moment the wound has completely dried until the skin is restored.

To prevent bedsores and skin damage from radiation, you can use either Actovegin cream or ointment. In this case, the choice between cream and ointment is made solely on the basis of individual preferences or considerations of ease of use of one form.

To prevent bedsores, cream or ointment is applied to areas of the skin in areas where there is a high risk of developing the latter.

To prevent damage to the skin by radiation, Actovegin cream or ointment is applied to the entire surface of the skin after radiotherapy, and once a day every day, in the intervals between regular radiation therapy sessions.

If it is necessary to treat severe trophic ulcers on the skin and soft tissues, then Actovegin gel, cream and ointment are recommended to be combined with the injection of the solution.

If, when using Actovegin gel, cream or ointment, pain and discharge appear in the area of ​​a wound defect or ulcer, the skin nearby turns red, and the body temperature rises, then this is a sign of infection of the wound. In such a situation, you should immediately stop using Actovegin and consult a doctor.

If, while using Actovegin, a wound or ulcerative defect does not heal within 2–3 weeks, then you should also consult a doctor.

For complete healing of defects, Actovegin gel, cream or ointment should be used for at least 12 days in a row.

Actovegin tablets - instructions for use (adults, children)

Tablets are intended for use for the same conditions and diseases as solutions for injection. However, the severity of the therapeutic effect with parenteral administration of Actovegin (injections and “droppers”) is stronger than when taking the drug in tablet form. That is why many doctors always recommend starting treatment with parenteral administration of Actovegin, followed by switching to taking tablets as consolidation therapy. That is, at the first stage of therapy, in order to quickly achieve the most pronounced therapeutic effect, it is recommended to administer Actovegin parenterally (injections or “droppers”), and then additionally drink the drug in tablets to consolidate the effect achieved by injections for a long period of time.

However, tablets can be taken without prior parenteral administration of Actovegin, if for some reason it is impossible to give injections or the condition is not severe, for the normalization of which the effect of the tablet form of the drug is quite sufficient.

The tablets should be taken 15 - 30 minutes before meals, swallowing them whole, without biting, chewing, breaking or crushing in any other way, but with a small amount of non-carbonated clean water (half a glass is enough). As an exception, when using Actovegin tablets for children, it is allowed to divide them into halves and quarters, which are then dissolved in a small amount of water and given to children in a diluted form.

For various conditions and diseases, adults are recommended to take 1 - 2 tablets 3 times a day for 4 - 6 weeks. Children are given Actovegin tablets 1/4 - 1/2 2 - 3 times a day for 4 - 6 weeks. The indicated adult and children's dosages are average, approximate, and the specific dose and frequency of taking tablets in each case should be determined by the doctor individually, based on the severity of symptoms and the severity of the pathology. The minimum course of therapy should be at least 4 weeks, since with shorter periods of use the required therapeutic effect is not achieved.

For diabetic polyneuropathy, Actovegin is always first administered intravenously at 2000 mg per day daily for three weeks. And only after this they switch to taking the drug in tablets, 2–3 pieces 3 times a day, for 4–5 months. In this case, taking Actovegin tablets is a maintenance phase of therapy, which allows you to consolidate the positive therapeutic effect achieved by intravenous injections.

If a person develops allergic reactions while taking Actovegin tablets, the drug should be immediately discontinued and treated with antihistamines or glucocorticoids.

The tablets contain the dye quinoline yellow aluminum varnish (E104), which is considered potentially harmful, and therefore Actovegin tablets are prohibited for use in children under 18 years of age in the Republic of Kazakhstan. Such a rule, prohibiting the use of Actovegin tablets by children under 18 years of age, currently exists only in Kazakhstan among the countries of the former USSR. In Russia, Ukraine and Belarus, the drug is approved for use in children.

Actovegin injections - instructions for use

Dosages and general rules for using Actovegin solutions

Actovegin in ampoules of 2 ml, 5 ml and 10 ml is intended for parenteral administration - that is, for intravenous, intraarterial or intramuscular injections. In addition, the solution from ampoules can be added to ready-made compositions for infusions (“droppers”). Solutions in ampoules are ready for use. This means that they do not need to be pre-diluted, added, or otherwise prepared for use. To use the solutions, you simply need to open the ampoule and draw its contents into a syringe of the required volume, and then inject.

The concentration of the active component in ampoules of 2 ml, 5 ml and 10 ml is the same (40 mg/ml), and the difference between them is only in the total amount of the active component. Obviously, the total dose of the active component is minimal in ampoules of 2 ml (80 mg), average in ampoules of 5 ml (200 mg) and maximum in ampoules of 10 ml (400 mg). This is done for the convenience of using the drug, when to produce an injection you simply need to select an ampoule with a volume of solution that contains the required dosage (amount of active substance) prescribed by the doctor. Apart from the total content of the active substance, there is no difference between ampoules with a solution of 2 ml, 5 ml and 10 ml.

Ampoules with the solution should be stored in a dark place, protected from light, at an air temperature of 18 - 25 o C. This means that the ampoules should be stored in the cardboard box in which they were sold, or in any other one available. After opening the ampoule, the solution should be used immediately; storage is not allowed. You cannot use a solution that has been stored for some time in an opened ampoule, as microbes from the environment may enter it, which will disrupt the sterility of the drug and may cause negative consequences after injection.

The solution in ampoules has a yellowish tint, the intensity of which may vary in different batches of the drug, since it depends on the characteristics of the starting raw material. However, the difference in the color intensity of the solution does not affect the effectiveness of the drug.

Do not use a solution that contains particles or is cloudy. This solution should be thrown away.

Since Actovegin can cause allergic reactions, it is recommended to perform a test injection before starting therapy by injecting 2 ml of the solution intramuscularly. Further, if a person does not show signs of an allergic reaction within several hours, therapy can be safely carried out. The solution is administered in the required dosage intramuscularly, intraarterially or intravenously.

Ampoules with solutions are equipped with a breaking point for easy opening. The break point is bright red, applied to the tip of the ampoule. Ampoules should be opened as follows:

• Take the ampoule in your hands so that the breaking point is directed upward (as shown in Figure 1);
• Tap the glass with your finger and gently shake the ampoule so that the solution flows from the tip to the bottom;
• Using the fingers of your other hand, break off the tip of the ampoule in the area of ​​the point, moving away from you (as shown in Figure 2).

Picture 1– Correctly holding the ampoule with the breaking point facing upwards.

Figure 2– Correctly breaking off the tip of the ampoule to open it.

The dosage and method of administration of Actovegin solutions are determined by the doctor. However, you need to know that to achieve the fastest possible effect, it is optimal to administer Actovegin solutions intravenously or intra-arterially. The therapeutic effect is achieved somewhat more slowly with intramuscular administration. For intramuscular injections, more than 5 ml of Actovegin solution cannot be administered at a time, and for intravenous or intra-arterial injections, the drug can be administered in much larger quantities. This should be taken into account when choosing the method of drug administration.

Depending on the severity of the disease and the severity of clinical symptoms, 10–20 ml of solution is usually prescribed intravenously or intra-arterially on the first day. Then, from the second day until the end of therapy, 5–10 ml of solution is administered intravenously or 5 ml intramuscularly.

If it is decided to administer Actovegin by infusion (in the form of a “dropper”), then 10–20 ml of solution from ampoules (for example, 1–2 ampoules of 10 ml each) are poured into 200–300 ml of infusion solution (saline solution or 5% glucose solution) . Then the resulting solution is injected at a rate of 2 ml/min.

Depending on the type of disease for which Actovegin is used, the following dosages for injection of the solution are currently recommended:

• Metabolic and vascular disorders of the brain (traumatic brain injury, cerebrovascular insufficiency) - administer 5-25 ml of solution per day every day for two weeks. After completing the course of Actovegin injections, they switch to taking the drug in tablets in order to maintain and consolidate the achieved therapeutic effect. In addition, instead of switching to maintenance use of the drug in tablets, you can continue injecting Actovegin by injecting 5-10 ml of solution intravenously 3-4 times a week for two weeks.
• Ischemic stroke - Actovegin is administered by infusion ("dropper"), adding 20 - 50 ml of solution from ampoules to 200 - 300 ml of saline or 5% dextrose solution. At this dosage, the drug is administered by infusion every day for a week. Then, 10–20 ml of Actovegin solution from ampoules are added to 200–300 ml of infusion solution (saline or dextrose 5%) and administered in this dosage daily in the form of “droppers” for another two weeks. After completing the course of “droppers” with Actovegin, they switch to taking the drug in tablet form.
• Angiopathy (peripheral vascular disorders and their complications, for example, trophic ulcers) - Actovegin is administered by infusion ("dropper"), adding 20 - 30 ml of solution from ampoules to 200 ml of saline or 5% dextrose solution. At this dosage, the drug is administered intravenously every day for four weeks.
• Diabetic polyneuropathy - Actovegin is administered intravenously, 50 ml of solution from ampoules, daily for three weeks. After completing the course of injections, they switch to taking Actovegin in tablet form for 4 to 5 months to maintain the achieved therapeutic effect.
• Healing of wounds, ulcers, burns and other wound damage to the skin - a solution is administered from ampoules of 10 ml intravenously or 5 ml intramuscularly either daily or 3-4 times a week, depending on the speed of healing of the defect. In addition to injections, Actovegin can be used in the form of ointment, cream or gel to accelerate wound healing.
• Prevention and treatment of radiation injuries (during radiation therapy of tumors) of the skin and mucous membranes - Actovegin is administered 5 ml of solution from ampoules intravenously daily, in between radiation therapy sessions.
• Radiation cystitis - 10 ml of solution from ampoules is administered transurethrally (through the urethra) daily. Actovegin in this case is used in combination with antibiotics.

Rules for administering Actovegin intramuscularly

No more than 5 ml of solutions from ampoules can be administered intramuscularly at a time, since in larger quantities the drug can have a strong irritating effect on the tissue, which is manifested by severe pain. Therefore, for intramuscular administration, only ampoules of 2 ml or 5 ml of Actovegin solution should be used.

To perform an intramuscular injection, you first need to select an area of ​​the body where the muscles are close to the skin. Such areas are the lateral upper part of the thigh, the lateral upper third of the shoulder, the abdomen (in non-obese people) and the buttocks. Next, the area of ​​the body into which the injection will be made is wiped with an antiseptic (alcohol, Belasept, etc.). After this, open the ampoule, draw the solution from it into a syringe and turn it over with the needle up. Gently tap the surface of the syringe with your finger in the direction from the piston to the needle to remove air bubbles from the walls. Then, to remove air, press the syringe plunger until a drop or stream of solution appears at the tip of the needle. After this, the syringe needle is inserted perpendicular to the surface of the skin deep into the tissue. Then, pressing the piston, slowly release the solution into the tissue and remove the needle. The injection site is re-treated with an antiseptic.

Each time, a new place is chosen for injection, which should be 1 cm away from the marks from previous injections on all sides. You should not inject twice in the same place, focusing on the mark left on the skin after the injection.

Since Actovegin injections are painful, it is recommended to sit quietly for 5 to 10 minutes after the injection and wait until the pain subsides.

Actovegin solution for infusion - instructions for use

Actovegin infusion solutions are available in two varieties - saline solution or dextrose solution. There is no fundamental difference between them, so you can use any version of the finished solution. Such Actovegin solutions are available in 250 ml bottles in a form ready for infusion administration (“droppers”). Solutions for infusion are administered intravenously (dropper) or intra-arterially by stream (from a syringe, as intramuscularly). Injection into a vein should be carried out at a rate of 2 ml/min.

Since Actovegin can cause allergic reactions, it is recommended to make a test injection before the “dropper”, for which 2 ml of solution is injected intramuscularly. If after a few hours an allergic reaction has not developed, then you can safely begin administering the drug intravenously or intra-arterially in the required amount.

If a person develops allergic reactions while using Actovegin, then use of the drug should be stopped and the necessary therapy with antihistamines (Suprastin, Diphenhydramine, Telfast, Erius, Cetirizine, Cetrin, etc.) should be started. If the allergic reaction is very severe, then not only antihistamines, but also glucocorticoid hormones (Prednisolone, Betamethasone, Dexamethasone, etc.) should be used.

Solutions for infusion are colored yellowish, the shade of which may vary between drugs from different batches. However, such a difference in color intensity does not affect the effectiveness of the drug, since it is due to the characteristics of the raw materials used for the manufacture of Actovegin. Do not use solutions that are cloudy or contain floating particles visible to the eye.

The total duration of therapy is usually 10–20 infusions (“droppers”) per course, but if necessary, the duration of treatment can be increased by the doctor. Dosages of Actovegin for intravenous infusion for various conditions are as follows:

• Circulatory and metabolic disorders in the brain (traumatic brain injury, insufficient blood supply to the brain, etc.) - administer 250 - 500 ml (1 - 2 bottles) once a day every day for 2 - 4 weeks. Then, if necessary, in order to consolidate the obtained therapeutic effect, they switch to taking Actovegin tablets, or continue to administer the solution intravenously, 250 ml (1 bottle) 2-3 times a week for another 2 weeks.
• Acute cerebrovascular accidents (stroke, etc.) – administer 250–500 ml (1–2 bottles) once a day daily, or 3–4 times a week for 2–3 weeks. Next, if necessary, they switch to taking Actovegin tablets in order to consolidate the resulting therapeutic effect.
• Angiopathy (impaired peripheral circulation and its complications, for example, trophic ulcers) - administer 250 ml (1 bottle) once a day every day, or 3 to 4 times a week for 3 weeks. Simultaneously with the “droppers”, Actovegin can be used externally in the form of an ointment, cream or gel.
• Diabetic polyneuropathy - administer 250 - 500 ml (1 - 2 bottles) once a day daily, or 3 - 4 times a week for 3 weeks. Next, be sure to switch to taking Actovegin tablets in order to consolidate the resulting therapeutic effect.
• Trophic and other ulcers, as well as long-term non-healing wounds of any origin - administer 250 ml (1 bottle) once a day every day, or 3-4 times a week, until the wound defect is completely healed. Simultaneously with infusion administration, Actovegin can be used topically in the form of a gel, cream or ointment to accelerate wound healing.
• Prevention and treatment of radiation damage (during radiation therapy of tumors) of the skin and mucous membranes - administer 250 ml (1 bottle) one day before, and then daily throughout the course of radiation therapy, and also for an additional two weeks after last irradiation session.

special instructions

With repeated intravenous, intramuscular or intra-arterial administration of Actovegin, the level of blood electrolytes (calcium, potassium, sodium, chlorine) and the percentage of water in the body (hematocrit) should be monitored.

Since Actovegin can cause allergic reactions, it is recommended to make a test injection before parenteral administration (intravenous, intramuscular or intra-arterial). To do this, inject 2 ml of solution for infusion or solution for injection of Actovegin intramuscularly and wait 2 hours. If no signs of allergy appear within two hours, then Actovegin can be administered parenterally in the required quantities.

When using Actovegin tablets, gel, cream and ointment, a test injection is not necessary, since these dosage forms can be quickly discontinued if an allergic reaction develops.

Before using Actovegin solutions, you should always inspect them carefully. If the solution is cloudy or contains floating particles, it should not be used. Only transparent solutions that have a yellowish color of any intensity can be used. If solutions from different batches differ greatly in the intensity of the yellowish color, but are not cloudy and do not contain particles, then they can be used without fear, since the color of the drug may vary, as it is due to the characteristics of the raw material (bovine blood). Different variations in the color of the solution do not affect its effectiveness.

Actovegin solutions, both in ampoules and vials, should be used immediately after opening the packages. Open solutions cannot be stored. It is also unacceptable to use solutions that have been stored for some time in opened packaging.

For intravenous infusion ("droppers"), you can use both infusion solutions in 250 ml bottles and solutions in ampoules of 2 ml, 5 ml and 10 ml. Only solutions for infusion are ready for use and can be administered without preparation, and solutions from ampoules for installing a “dropper” must first be poured into the infusion solution in the required quantity (200 - 300 ml of saline solution, or 200 - 300 ml of dextrose solution, or 200 - 300 ml of 5% glucose solution).

A maximum of 5 ml of injection solution can be administered intramuscularly at a time. Injection solutions can be administered intravenously and intraarterially in large quantities (up to 100 ml at a time).

Overdose

In the Russian official instructions for use there are no indications of the possibility of overdose with any dosage forms of Actovegin. However, the instructions approved by the Ministry of Health of Kazakhstan indicate that when using Actovegin tablets and solutions, an overdose may occur, which is manifested by pain in the stomach or increased side effects. In such cases, it is recommended to discontinue use of the drug, perform gastric lavage and carry out symptomatic therapy aimed at maintaining the normal functioning of vital organs and systems.

An overdose of Actovegin gel, cream or ointment is impossible.

Impact on the ability to operate machinery

Not a single dosage form of Actovegin (ointment, cream, gel, tablets, solutions for injections and solutions for infusions) affects the ability to control mechanisms, therefore, while using the drug in any form, a person can engage in any type of activity, including those requiring high speed of reactions and concentration of attention.

Interaction with other drugs

Forms of Actovegin for external use (gel, cream and ointment) do not interact with other drugs. Therefore, they can be used in combination with any other means, both for oral administration (tablets, capsules) and for local use (creams, ointments, etc.). Only if Actovegin is used in combination with other external agents (ointments, creams, lotions, etc.), a half-hour interval should be maintained between applications of the two drugs, and not applied immediately after each other.

Actovegin solutions and tablets also do not interact with other medications, so they can be used as part of complex therapy with any other drugs. However, it must be remembered that Actovegin solutions cannot be mixed in the same syringe or in the same “dropper” with other medications.

With caution, Actovegin solutions should be combined with potassium preparations, potassium-sparing diuretics (Spironolactone, Veroshpiron, etc.) and ACE inhibitors (Captopril, Lisinopril, Enalapril, etc.).

How to give an intramuscular injection (in the buttock) - video

Before use, you should consult a specialist.

Actovegin injections help activate metabolism by increasing the transport and accumulation of oxygen and glucose, increasing intracellular utilization. This entails an acceleration of the metabolism of adenosine triphosphoric acid, increasing cellular energy resources.

When the normal functions of energy metabolism are limited and energy consumption is high, Actovegin helps stimulate the energy processes of functional metabolism and the absorption of substances by the human body. In addition, Actovegin increases blood circulation.

In this article we will look at when doctors prescribe the drug Actovegin, including instructions for use, analogues and prices for this drug in pharmacies. If you have already used Actoveginov injections, leave your feedback in the comments.

Composition and release form

According to the annotation, the main solution in the solution is deproteinized hemoderivative of calf blood, with 40 mg of dry matter per 1 ml. This term is the international non-proprietary name of the drug - INN. Actovegin also contains auxiliary components:

• water for injections;
• sodium chloride;
• anhydrous glucose.

The drug can have several forms of release: tablets (capsules), ointment, cream, gel, injection solution. The last form (solution) has the most pronounced therapeutic effect, since Actovegin injections can be injected directly into a vein or artery. Intramuscular administration is less commonly used.

Indications for use

Cerebral vascular disorders, metabolic deterioration:

1. Injury;
2. Ischemic stroke.

Venous, arterial peripheral disruptions in the functioning of the vascular system, incl. pathological consequences:

1. Trophic ulcerative lesions;
2. Angiopathy.

Damage to the epidermis:

1. Ulcers of various origins.
2. Burns;
3. Bedsores;
4. Poor wound healing.

Therapy of skin and mucous membrane lesions resulting from radiation exposure.

pharmachologic effect

ACTOVEGIN is a hemoderivative that is obtained through dialysis and ultrafiltration (compounds with a molecular weight of less than 5000 daltons pass through).

It has a positive effect on the transport and utilization of glucose, stimulates oxygen consumption (which leads to the stabilization of plasma membranes of cells during ischemia and a decrease in the formation of lactates), thus having an antihypoxic effect, which begins to manifest itself no later than 30 minutes after parenteral administration and reaches a maximum on average after 3 hours (2-6 hours). ACTOVEGIN increases the concentrations of adenosine triphosphate, adenosine diphosphate, phosphocreatine, as well as amino acids - glutamate, aspartate and gamma-aminobutyric acid.

Instructions for use

For the intravenous route of administration, Actovegin can be administered drip or stream. Before administration into a vein, the drug must be dissolved in a 0.9% physiological sodium chloride solution or in a 5% glucose solution. The permitted final dose of Actovegin is up to 2000 mg of dry matter per 250 ml of solution.

For intravenous administration, Actovegin should be used in a dosage of 5 to 20 ml per day. The dose when administered intramuscularly cannot exceed 5 ml in 24 hours. In this case, the introduction is carried out slowly.

After assessing the patient’s condition, the required dose is selected. The recommended dosage at the beginning of therapy is 5–10 ml intravenously or intravenously. In the following days, 5 ml intravenously or intramuscularly daily or several times over a 7-day period.

• Metabolic and vascular disorders of the brain: at the beginning of treatment, 10 ml intravenously daily for two weeks, then 5-10 ml intravenously 3-4 times a week for at least 2 weeks.
• For ischemic stroke, Actovegin is prescribed 20-50 ml, adding 200-300 ml of the main solution intravenously daily for a week, then 10-20 ml intravenously for two weeks.
• Peripheral (arterial and venous) vascular disorders and their consequences: 20-30 ml of the drug in 200 ml of the main solution intra-arterially or intravenously daily; Duration of treatment is about 4 weeks.
• Wound healing: 10 ml intravenously or 5 ml intramuscularly daily or 3-4 times a week depending on the healing process (in addition to local treatment with Actovegin in dosage forms for topical use).
• For the prevention and treatment of radiation damage to the skin and mucous membranes, the average dose of the drug is 5 ml intravenously daily.

Additional instructions for the use of Actovegin:

1. When administering Actovegin intramuscularly, do not exceed a dose of 5 ml of solution, because it is hypertonic (concentrated).
2. It is always necessary to carry out a test reaction of Actovegin (2 ml of solution) due to possible anaphylactic reactions.
3. Actovegin solution is compatible with sodium chloride solutions and 5% glucose solution. It is not recommended to mix with other solutions.

Intramuscular injections are given slowly.

Contraindications

The doctor cannot prescribe medication in the following cases:

1. Pulmonary edema.
2. High sensitivity to the drug.
3. Heart failure (in the absence of decompensation).
4. Anuria is a lack of filling of the bladder with urine.
5. Oliguria is a slowdown in urine production.
6. Pathological fluid retention.

Side effects

Sometimes allergic reactions occur in the form of hives, redness of the skin, increased body temperature - up to anaphylactic shock.

Extremely rare side effects may include:

• blood pressure surges;
• tachycardia and heart pain;
• headache and weakness;
• chest pain and shortness of breath;
• muscle-joint pain;
• nervous overexcitation (especially typical for children, so Actovegin is prescribed to young patients only in the first half of the day).

The most common side effect from intramuscular injections of Actovegin is the formation of painful lumps and lumps at the injection site.

Analogs

There are known analogues of Actovegin, which today have a good pharmacological reputation. One of these is Solcoseryl. It has a protective effect on tissues with nutritional deficiency and hypoxia, helps in their regeneration and accelerates wound healing processes.

• Cerebrolysin is a neotropical drug that improves aerobic metabolism in brain cells and normalizes protein synthesis and can be prescribed by a doctor in the absence of Actovegin.

Among the drugs with similar pharmacological properties, it is worth noting Cortexin injection solution, which is used in the treatment of chronic circulatory pathologies in brain tissue, encephalopathy and epilepsy.

Prices

The average price for Actovegin injection solution 40 mg/ml ampoules 5 ml 5 pcs, in pharmacies (Moscow) 638 rubles.

Storage conditions and periods

The drug should be stored in a place protected from light at a temperature of 18° to 25°C. Shelf life – 3 years.

Actovegin is one of the popular vascular drugs; it is recommended to improve general and local blood supply. Injections are considered the most effective method of treatment with Actovegin.

Actovegin - description of the drug

Actovegin in ampoules- a medicine for optimizing metabolism, trophism and tissue regeneration. The drug is produced by the Austrian company " Takeda Pharmaceuticals", price for 5 ampoules (5 mg) - 640 rubles, price for 5 ampoules (10 mg) - 1160 rubles. Externally, the solution for injection is transparent, slightly yellowish, and normally does not contain insoluble particles or sediment.

The product contains a deproteinized hemoderivat obtained from elements of the blood of young cattle. Auxiliary ingredients of the solution - water. In addition to ampoules, Actovegin is produced in the form of:

• tablets;
• ointments;
• gel.

Since the medicine is created from calf blood, it is akin to the natural environment of the human body, therefore it is approved for use even in children. Hemoderivat is a complex complex of amino acids, nucleotides and other substances valuable to the body, necessary for the normal functioning of the nervous system and blood vessels. The effectiveness of the medicine is confirmed by the experience of doctors and patients, which is why Actovegin in ampoules has been presented on the pharmaceutical market for more than 30 years.

Action of Actovegin

Intramuscular and intravenous injections of Actovegin are prescribed for the treatment of various pathologies accompanied by the following changes in the body:

• hypoxia (oxygen starvation) in tissues, ischemic processes (consequences of lack of oxygen);
• tissue trophic disorders;
• slow cell regeneration;
• reduced intensity of metabolic processes.

The drug compares favorably with analogues in its high efficiency and minimum side effects. Through dialysis and special filtration, a substance is created whose molecules are very small in size. This allows the drug to penetrate the protective barriers in the body, providing a lot of positive effects.

It is impossible to discover the exact routes and timing of Actovegin’s removal from the body - its components are practically indistinguishable from the natural environment of cells.

After injection into the muscle or venous bloodstream, the active elements almost immediately begin to realize their effects:

The result is a powerful antihypoxic effect and improved metabolism at all levels, optimization of blood flow and microcirculation. The amount of amino acids, ATP and other elements in the body increases. Maximum effect recorded in 2-6 hours, but the medicine begins to work within 10-30 minutes.

Indications for use

During pregnancy, Actovegin is often prescribed intramuscularly or intravenously- this drug helps to increase placental blood flow, after which fetal development occurs at a more intense pace.

Often, mild degrees of fetal underdevelopment (discrepancy between the size of the arms, legs, head, and organs and weeks of gestation) are quickly corrected after a course of drug administration.

Indications for the use of Actovegin injections are very diverse. Among cardiovascular and nervous pathologies they may be:

For adults and children, the medicine is indicated for use in the presence of large wounds and poorly healing cuts. Elderly people and people who have suffered trauma, surgery, or who are on bed rest are often given Actovegin injections for bedsores. Actovegin is indicated for diabetics to heal ulcers and get rid of trophic disorders. The drug significantly improves the condition of the skin in case of burns, so the indications for use are supplemented by burn disease, radiation, and chemical damage to the skin.

Instructions for use

The drug in this dosage form can only be used as prescribed by a doctor. The solution can be used in different ways - by injection into a vein, into a muscle, by drip with saline, or in combination with other drugs. The solution is ready for use, it can be used in its pure form, but still, to reduce the risk of allergic reactions, many patients are recommended to dilute Actovegin sodium chloride 1:1.

Depending on the volume of the ampoule, the amount of the active component can be 2,5,10 ml, while its concentration is always the same - 40 mg/ml.

After opening the ampoule, the solution is taken from it immediately; storage is unacceptable.

If for some reason only part of the solution was used, the remaining drug must be disposed of. Before the first use, you should perform an allergy test - a test injection of 2 ml of the product into the gluteal muscle. In the absence of an immediate reaction (within half an hour), use in the required dose is allowed. The drug is administered only slowly! The application standards are as follows:

• for intramuscular administration - no more than 5 ml/one procedure;
• for intravenous, intra-arterial administration - 10-20 ml of solution on the first day, then 5-10 ml/day, unless a different treatment order is prescribed by the doctor.

10-20 ml of solution per 200-300 ml of 0.9% sodium chloride is injected dropwise, or a glucose solution is used for dilution. The rate of administration is not higher than 2 ml/minute. For some types of cystitis, Actovegin is injected into the urethra 5-10 ml with saline solution. The course of therapy is 10-20 days daily.

Side effects, contraindications

Typically, injections are not prescribed for children under 3 years of age, but this issue is resolved with a specialist on an individual basis. Contraindications include:

• severe heart failure;
• swelling of the lung tissue;
• urinary retention - complete and partial;
• severe peripheral edema;
• history of allergic reactions to Actovegin.

If the content of sodium or chlorine in the body is high, the drug should be used with caution. Side effects may include skin rash, urticaria, itching, redness of the injection site, headache, abdominal pain, diarrhea, hyperhidrosis, fluid stagnation in the body. Severe allergic reactions, including anaphylaxis, have been observed rarely. But usually the medicine is well tolerated by patients.

Actovegin is a drug that activates metabolism, improves tissue nutrition, reduces tissue hypoxia and stimulates regeneration. Is it possible to inject Actovegin intramuscularly? Doctors at the Yusupov Hospital prescribe Actovegin in the form of intramuscular and intravenous injections and infusions. The drug can be taken orally in tablet form. Actovegin ointments, creams and gels are applied to the skin.

The drug is used in endocrinology, neurology, vascular surgery, obstetrics and pediatrics. At the Yusupov Hospital, before prescribing Actovegin intramuscularly, doctors conduct a comprehensive examination of the patient using modern diagnostic equipment from the world's leading manufacturers and laboratory diagnostic methods. The drug is prescribed intramuscularly according to the instructions for use of Actovegin. Doctors individually determine the route of administration of the drug, dose and duration of therapy.

Instructions for use of Actovegin

Actovegin solution is injected intramuscularly, which is in ampoules of 2 or 5 ml. Ampoules containing 10 ml are not used for intramuscular administration, since the maximum permissible dose of the drug that can be injected into the muscle is 5 ml, and the contents of an opened ampoule cannot be stored.

One milliliter of solution contains 40 mg of the main active ingredient - purified calf blood extract, 2 ml - 80 mg, 5 ml - 200 mg. The active substance actovegin contains the following components:

• Amino acids;
• Macroelements;
• Microelements;
• Fatty acid;
• Oligopeptides.

The auxiliary ingredients are water for injection and sodium chloride. Actovegin solution is a clear, colorless or yellowish liquid. If it becomes cloudy or flakes form, the drug should not be administered intramuscularly.

Indications and contraindications for intramuscular administration of Actovegin

Actovegin has a complex mechanism of action, which provides a variety of pharmacological effects. It is used in the treatment of many diseases. Doctors at the Yusupov Hospital prescribe it if necessary to improve the nutrition of body tissues and increase their resistance to hypoxia. This ensures minimal damage to body cells in conditions of insufficient oxygen supply.

Actovegin according to the instructions is administered intramuscularly in the presence of the following indications:

• Transient cerebrovascular accidents;
• Ischemic stroke;
• Encephalopathy;
• Cerebral atherosclerosis;
• Angiopathy;
• Diabetic polyneuropathy.

Intramuscular injections of Actovegin are indicated for frostbite, burns, and trophic ulcers. The drug is administered intramuscularly to patients suffering from obliterating diseases of peripheral vessels, varicose veins, and diabetic angiopathy. Doctors prescribe intramuscular injections of Actovegin for mild or moderate diseases.

How to administer Actovegin intramuscularly

How to inject Actovegin intramuscularly? When administering Actovegin intramuscularly, nurses at the Yusupov Hospital strictly adhere to the instructions for use of the drug. Intramuscular injections of the drug are made according to the algorithm:

• Before carrying out the manipulation, wash your hands thoroughly with soap and treat them with an antiseptic solution;
• Wear sterile disposable gloves;
• The ampoule with Actovegin is warmed in the hand and wiped with alcohol;
• The ampoule is held vertically, by lightly tapping your fingers on it to ensure that all the solution is in the lower part, break off its tip along the line with the red dot;
• Draw the solution into a disposable sterile syringe and release the air;
• Visually divide the buttock into 4 parts and insert a needle into the outer upper square, having previously treated the skin with a cotton swab and alcohol;
• The drug is administered slowly;
• After the injection, clamp the injection site with a napkin or cotton ball moistened with alcohol.

Recommended doses of Actovegin for intramuscular administration

According to the instructions for use of Actovegin, 2-5 ml of the drug can be administered intramuscularly. The attending physician, taking into account the indications, the severity of the disease and the effectiveness of the treatment, may change the recommended doses. For diseases of the central nervous system, 5 ml of Actovegin is usually administered daily for two weeks. Then doctors prescribe Actovegin tablets in maintenance doses.

To speed up the process of tissue regeneration in case of wounds, frostbite and other damage to the epidermis, daily intramuscular injections of 5 ml of Actovegin solution are recommended. Additionally, pharmacological forms of the drug such as gel, ointment or cream are used. Actovegin is administered intramuscularly for mild to moderate severity of diseases. In more complex cases, doctors prescribe intravenous injections or infusions of the drug.

Precautions for intramuscular administration of Actovegin

To ensure maximum effectiveness and safety during treatment with Actovegin, individual intolerance to the drug is determined at the beginning of therapy. To do this, 2 ml of the drug is injected intramuscularly over 1-2 minutes. Long-term administration allows you to observe the body's response to the medicine and, if allergic reactions develop, stop the injection in time. The treatment rooms at the Yusupov Hospital are equipped with an anti-shock kit, which allows you to immediately provide emergency care to the patient.

The use of disposable syringes and modern antiseptic solutions allows you to protect the patient from infection by pathogens of infectious diseases that are transmitted by blood. Nurses are fluent in the technique of intramuscular injections. An open ampoule is used immediately, since the absence of preservatives in the solution does not allow it to be stored for a long time. For this reason, patients are recommended to purchase ampoules of the volume that is administered once.

Actovegin is stored in the refrigerator. Before using the drug, the ampoule is slightly warmed in your hands to ensure more comfortable administration. Do not use a solution that is cloudy or contains visible sediment. As evidenced by the instructions for using Actovegin, children can be given injections of the drug intramuscularly from the age of three.

You can administer Mexidol and Actovegin together intramuscularly. The treatment regimen is determined by the doctor. During treatment with Actovegin, doctors recommend that patients stop drinking alcohol. To get advice on using Actovegin, call us.

Bibliography

• ICD-10 (International Classification of Diseases)
• Yusupov Hospital
• Badalyan L. O. Neuropathology. - M.: Education, 1982. - P.307-308.
• Bogolyubov, Medical rehabilitation (manual, in 3 volumes). // Moscow - Perm. - 1998.
• Popov S. N. Physical rehabilitation. 2005. - P.608.

Prices for services *

*The information on the site is for informational purposes only. All materials and prices posted on the site are not a public offer, defined by the provisions of Art. 437 Civil Code of the Russian Federation. For accurate information, please contact the clinic staff or visit our clinic. The list of paid services provided is indicated in the price list of the Yusupov Hospital.

*The information on the site is for informational purposes only. All materials and prices posted on the site are not a public offer, defined by the provisions of Art. 437 Civil Code of the Russian Federation. For accurate information, please contact the clinic staff or visit our clinic.

There is a separate dosage form for each method of application.

Characteristics of the medicine

For the production of Actovegin, the blood of dairy calves is used, from which a deproteinized hemoderivative is obtained through dialysis and ultrafiltration. It contains amino acids, macroelements, microelements, fatty acids, oligopeptides and other important physiological components.

Having received a doctor’s prescription for therapy with the ampoule form of the drug, many wonder whether Actovegin can be injected intramuscularly or whether an intravenous infusion will be required. The answer can be obtained either from a doctor or pharmacist, or by reading the package insert for the medicine - the drug is used for intramuscular use.

Actovegin is produced in several dosage forms: solution for injection, ointment, tablets, cream, solution for infusion and gel. This allows each patient to choose the ideal product.

In particular, Actovegin injections are carried out intramuscularly using an injection solution. It is a transparent liquid, yellowish in color or completely colorless. The drug is sold in ampoules of 2, 5 and 10 ml. The active component is included in the solution in an amount of 40 mg per ml. Thus, 2 ml contains 80 mg of hemoderivat, 5 ml - 200 mg, and 10 ml - 400 mg. Excipients are water for injection and sodium chloride.

Indications of the medicine

The drug has a complex mechanism of action that provides a variety of its pharmacological effects, therefore it is used in the treatment of many diseases in different fields of medicine. Its purpose is justified when it is necessary to improve the nutrition of body tissues, increase their resistance to hypoxia, which ensures a minimum amount of damage to the structures of the body’s cells in conditions of oxygen deficiency.

Actovegin according to the instructions for intramuscular injection is used for:

• abnormal dilatation of cerebral vessels;
• retinal damage;
• dyscirculatory encephalopathy;
• ischemia and oxygen starvation of organs;
• vascular atherosclerosis;
• ischemic strokes;
• vascular angiopathy;
• extensive burns of chemical and thermal nature;
• cerebral insufficiency;
• wounds and bedsores;
• diabetic polyneuropathies;
• frostbite;
• traumatic brain injuries;
• radiation and radiation damage to the skin and mucous membranes.

How to use

Depending on the severity of the disease, intramuscular or infusion medication is prescribed. The decision about this, as well as about the dosage of the drug, is made by the doctor.

Instructions for administering injections intramuscularly:

• Before carrying out the manipulation, you should thoroughly wash your hands with soap and treat with an antiseptic;
• The ampoule needs to be slightly warmed in your hand before administration;
• Holding the ampoule vertically and lightly tapping it so that all the solution is in the lower part, break off its tip along the line with the red dot;
• Take the medicine with a sterile syringe, then turn it upside down and release a drop of the solution to make sure that all the air has come out;
• Visually divide the buttock into 4 parts and insert a needle into the upper outer square, having previously treated the skin with a cotton swab and alcohol;
• The drug is administered slowly;
• After the injection, clamp the injection site with cotton wool or a napkin moistened with alcohol.

In injections, according to the instructions for use, Actovegin is used at 2-5 milliliters per day. Administration can be carried out from 1 to 3 times a day.

The attending physician, based on the presence of indications, the severity of the disease and the effectiveness of the treatment, may change the recommended doses in one direction or another. If it is necessary to administer the drug in doses exceeding 5 ml, it is recommended to use Actovegin intravenously.

The following doses of the drug are usually prescribed:

• In case of cerebral circulatory insufficiency, 5 ml of medication is used for 14 days. Next, a tablet form is prescribed to support the effect;
• To speed up the process of tissue regeneration in case of wounds, frostbite and other damage to the epidermis, daily injections of 5 ml of Actovegin solution are indicated. Additionally, local forms of the drug are used - ointment, cream or gel.

Intramuscular administration is used for mild to moderate diseases, while in more complex cases, infusions into a vein are required.

Precautionary measures

To ensure maximum effectiveness and safety when treating with Actovegin injections, you must adhere to the rules for its use.

Before starting full therapy, the presence of individual intolerance should be determined. To do this, 2 ml of medication is injected intramuscularly over 1-2 minutes. Long-term administration allows you to observe the body's response to the drug and, if anaphylaxis develops, you can stop the injection in time and begin resuscitation of the patient.

From the above, the following rule of admission follows: injections must be given in a medical institution, where, if necessary, emergency care can be obtained. If home treatment is still intended, then at least the first dose should be administered in the hospital under the supervision of medical staff.

Actovegin can be administered intramuscularly in a dose not exceeding 5 ml, since the solution is hypertonic and can provoke a sharp jump in blood pressure.

It is important to create the most sterile conditions possible when administering the drug. An open ampoule must be used immediately, since the medicine does not contain preservatives that would ensure longer storage. Therefore, the drug should be purchased in ampoules of the volume that needs to be injected at a time. After all, storing an opened ampoule is prohibited.

Actovegin should be stored in the refrigerator, so before use, the ampoule should be slightly warmed in your hands to ensure more comfortable administration.

A solution with visible sediment or if it is cloudy must not be used. The contents of the ampoule should be yellowish in color and transparent.

Actovegin may be included in complex treatment regimens for diseases, since no negative interaction reactions with other medications have been established. It should be borne in mind that mixing it with other drugs in one bottle or syringe is strictly prohibited. An exception is solutions of sodium chloride and glucose, which are recommended for the preparation of infusion solutions. It is also prohibited to drink alcohol during treatment with the drug.

Side effects

Actovegin is well tolerated. The most common negative effect during its treatment is allergic reactions, including angioedema. Much less common are:

• redness or paleness of the skin;
• dizziness;
• chest pain;
• indigestion;
• increased frequency and difficulty breathing;
• general weakness;
• increased blood pressure;
• muscle and joint soreness;
• increased heart rate;
• fever;
• paresthesia;
• attacks of suffocation.

If any undesirable reactions of the body to the use of the drug occur, therapy with Actovegin should be stopped and symptomatic treatment prescribed.

When using Actovegin injections intramuscularly, you need to take into account that this is a rather unpleasant and painful procedure. Therefore, it is preferable to administer it intravenously along with a solution of glucose or sodium chloride.

Contraindications

Actovegin has a high safety profile, which allows it to be used in a wide range of patients. However, there are exceptions. Intramuscular injections of Actovegin are prohibited for:

• hypersensitivity to the components of the product;
• heart failure;
• disturbances in the outflow of urine;
• pulmonary edema;
• kidney diseases.

Use of the drug in special groups of patients

According to the instructions, the drug should not be prescribed in pediatrics due to the lack of a sufficient number of relevant studies. But in practice, many doctors use Actovegin to treat infants and children.

Intramuscular injections of the drug are practically not used in this category of patients due to the painfulness of the procedure. The exception is infants with consequences of intrauterine hypoxia. But such injections are administered only in a hospital setting under constant medical supervision.

Actovegin is prescribed to pregnant women with caution, after assessing the possible consequences for the fetus. If it is necessary to administer the drug to such patients, preference is given to intravenous administration at the beginning of treatment, with a further transition to intramuscular administration or taking tablets when the condition improves.

Indications for use include: threat of miscarriage, feto-placental insufficiency, placental abruption, Rh conflict, slow fetal weight gain or low motor activity.

The use of the drug during lactation is also allowed, but only if its therapeutic effect on the mother’s body exceeds the potential risk for the baby.

In geriatrics, the drug is used quite often. At the same time, judging by the reviews, it is in old age that the positive effect of Actovegin is best manifested.

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IMPORTANT. The information on the site is provided for informational purposes only. Do not self-medicate. At the first sign of disease, consult a doctor.

All about Actovegin

All about the unique drug - Actovegin

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Actovegin - injections. Video. Instructions for injections

So why is sometimes an injection better than a pill?

The injection has a sister - this is a dropper, which is used when a lot of medicine needs to be administered and it should be administered only gradually.

Using a syringe, draw the solution from the ampoule (to avoid air getting in, you need to release a drop of the solution, holding the syringe with the needle up).

Naturally, everything should be sterile ( Here you can see video).

Or: five ml of IV medication solution - between therapy sessions.

Therefore, in such a situation, treatment with Actovegin is suspended and antihistamine (and, if necessary, corticosteroid) treatment is carried out.

Actovegin injections intramuscularly: administer slowly no more than 5 ml (since this drug is hypertonic).

Injections can be given both in the morning and in the evening.

It is extremely undesirable for children, but in practice (in exceptional cases) Actovegin injections are given. In this case, the doctor evaluates all risks.

After opening the bottle or ampoule, Actovegin solution cannot be stored and then reused for injections: this will not only not give any effect, but is simply dangerous to health.

With frequent use of Actovegin injections in patient therapy, it is necessary to check the electrolyte composition of the serum (K, Na, Ca, Cl, Mg.), as well as the water balance of the patient’s body.

Treatment with Actovegin can only be carried out after consulting a doctor.- a specialist and only after examining the patient. Neither self-medication nor consultations given in absentia are recommended, because this can lead to complications.

Nevertheless, you can read reviews about Actovegin injections.

Actovegin also comes in the form of tablets, gel, and ointment.

Keep ampoules should be in a dark place at room temperature (not higher than 25 ° C), in packaging, out of reach of children.

You may be interested in general instructions for using Actovegin, the compatibility of Actovegin with other medications, reviews of Actovegin from our readers, the price and manufacturers of the drug (and also its analogue Solcoseryl), the use of Actovegin in sports and in veterinary medicine (for the treatment of our pets).

You will find answers to these and many other questions on our website.

What time of day is it better to give an Actovegin injection?

Development of a child with ID (finished).

Thanks for the ideas, let’s implement them soon :)

Well, actually, everything is simple, he will need to tweet when those around him will not understand him without tweeting;) That is. Any information you learn needs to be applied in everyday life: “go get me 2+2 pencils.” find an object starting with the letter A. make a “cake” from the letters and get a piece. "and other bullshit in current daily life.

Before pregnancy, I never had problems with veins.

Before pregnancy, I never had problems with veins, I always had straight and slender legs. And as soon as I became pregnant, it immediately became difficult to walk in heels, although my belly was not yet visible. Further - worse. My legs began to swell, filled with lead, and hurt at night. At first, the gynecologist said that this was normal for an expectant mother, because the load increases, but when my spider veins began to come out, it became clear that the matter was serious. Then I specifically asked the doctor about how.

Harm from pills to the fetus. Blog of user Barinvakti on 7ya.ru

Hello, I am very worried, I live abroad, I have 5.5 weeks, severe cramps, the doctor said there is a threat of miscarriage, and they prescribed me 3 progesterone injections, progesterone suppositories and spasmalgon (2 tablets 3 times a day). In almost 2 days I was given 3 injections of progesterone. After the third progesterone shot, I fainted and my cramping pain became much worse. I have questions: could there be an overdose of progesterone? What made the spasms more painful? During the ultrasound, the doctor said that the fetus was well attached.

When to start injecting? Botox and hyaluronic acid at 20, 40.

Anti-wrinkle cream, Botox or hyaluronic acid injections

Hypertensive crisis: are our parents treated correctly?

Treatment of hypertensive crisis. How do hypertension medications work?

My daughter's birthday.

And it flew away. 4:30 They shake me by the leg and spread my arms with the word “That’s it.” I still don’t understand anything, because I’m dying to sleep after a sleepless night of wallpapering. Somehow I wake up. Alenka explains to me that the mucus plug has finally come off and she is having contractions. In general, the fact that the plug has finally come off is a harbinger, but a few days may still pass before the birth. Yes, and the contractions may well be trial ones (by the way, we have already sat with such trial ones at the dacha for an hour.

For those who lose apples.

It’s very strange, but for some reason none of my friends know that you can make a wonderful thing from apples—marshmallow. Which is incredibly pleasant to chew in winter and remember summer and childhood :)) For me, this is exactly the taste of childhood. My grandmother always prepared this delicacy for the winter. In general, if you have uneatable apples or just extra apples, I recommend making marshmallows. The cooking process is indecently simple. Peel and core the apples, cut into pieces and.

Just pour the puree onto the parchment and smooth it out with a spatula?

what thickness should this puree be initially? :)))))

I need to do this urgently!!)))

Israeli cosmetics Lamerel - an alternative to injections?.

Good day to all! The other day I tried new Lamerel cosmetics from Israel - a cream with a lifting effect. I was pleasantly surprised - the effect was quick and pleasant (the oval of the face was somehow tightened, the color was fresher, the skin looked like it was on vacation). I’m sitting here racking my brains - what to do when I run out - where can I buy Lamerel cosmetics in St. Petersburg? Should I fly to Eilat again to pick her up? Write, who knows what and who else has tried this cosmetics?

If necessary, I'll inject myself. Vaccination (vaccinations) | How are vaccinations done?

Post-vaccination reactions occur much more often, but they do not cause harm to health and, as a rule, do not require treatment. These include: An increase in temperature to °C in the first three days after vaccination. In this case, suppositories, tablets or syrup with paracetamol or ibuprofen help well. Attention! It is not recommended to use aspirin to reduce fever! Also, you should not take this drug for a month after vaccination against chickenpox - this risks severe liver damage. In the case of using live vaccines, 7-14 days after vaccination, the development of a “miniature disease” is possible (a rash appears, the joint swells.

Nutrition of children with pathological regurgitation syndrome.

Almost all young mothers are concerned that their babies spit up after feeding. This is usually caused by aerophagia (air entering the esophagus during sucking). This is absolutely normal for infants.

Caesarean section: recover without loss! C-section

Recovery after caesarean section

Drugs for placental insufficiency. Vitamins.

Based on a comprehensive examination, a conclusion is made not only about the presence or absence of placental insufficiency, but also about the severity of such a disorder. The tactics of pregnancy management for different degrees of severity of placental insufficiency are different. Prevention and treatment Currently, unfortunately, it is not possible to completely rid a pregnant woman of the resulting placental insufficiency by any therapeutic effects. The means of therapy used can only help to stabilize the existing pathological process and maintain compensatory and adaptive mechanisms at a level that allows for the continuation of pregnancy until the optimal date of delivery. Therefore, it is very important to carry out prevention in women who have risk factors for developing platonic syndrome.

Actovegin increases the resistance of the brain and fetal tissues to hypoxia, activates metabolism, increases glucose consumption, and stimulates the renewal of fetal cells. In addition, the drug increases blood circulation in the mother-placenta-fetus system and promotes better tolerance of the birth act to the fetus. Treatment with Actovegin has a pronounced effect on the condition of the fetus. This is reflected in improved blood flow and improved fetal growth, which reduces the incidence of forced early delivery. The drug is obtained from the blood of calves, has a minimum of side effects, and allergic reactions are quite rare. Contraindications to the use of the drug are heart failure.

Mom is giving injections - I need help. We need your experience and knowledge.

Who has experience in this matter? I need your help, otherwise my brain is about to boil :) We prescribed a course of treatment for the child, prescribed a bunch of medications, incl. you need to give injections: 1. Cerebrolysin 1.0 ml intramuscularly 2. Actovegin 2.0 ml intramuscularly 3. Neuromidin 5 mg 0.5 ml intramuscularly The injections will have to be given to the mother, i.e. to myself. I’m terribly afraid, and I’ve never given injections myself in my life. I only have experience in diluting Cortexin injections and, accordingly, I saw where to inject and how to administer. Those. With.

For mothers of restless children: PEP - myths and reality.

You can minimize your mother’s time of “lack of sleep” with the help of rational organization of joint sleep and night feedings. Very often, children sleep better next to their mothers. Rocking motion can also be replaced by breastfeeding before bedtime. When I found out that it was “possible” to do this, the time of motion sickness decreased significantly. Often children wake up after sleep in a bad mood, you can also offer the breast, and the world will make the baby happy again! Secondly, this is the classification as pathological of a number of adaptive, passing phenomena on the part of the newborn’s nervous system (for example, shuddering or throwing up of arms and legs, trembling of the chin with strong crying, etc.).

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Actovegin - instructions for use (injections, tablets, ointment, gel, cream). Why is Actovegin prescribed?

Varieties, names, composition and release forms

Currently, Actovegin is available in the following dosage forms (which are also sometimes called varieties):

• Gel for external use;
• Ointment for external use;
• Cream for external use;
• Solution for infusion (“droppers”) on dextrose in 250 ml bottles;
• Solution for infusion with 0.9% sodium chloride (saline) in 250 ml bottles;
• Solution for injection in ampoules of 2 ml, 5 ml and 10 ml;
• Tablets for oral administration.

Actovegin gel, cream, ointment and tablets do not have any other common simplified name. But forms for injection are often called simplified names in everyday life. Thus, the injection solution is often called “Actovegin ampoules”, “Actovegin injections”, as well as “Actovegin 5”, “Actovegin 10”. In the names “Actovegin 5” and “Actovegin 10” the numbers indicate the number of milliliters in an ampoule with a solution ready for administration.

• Actovegin gel - contains 20 ml of hemoderivate (0.8 g in dried form) in 100 ml of gel, which corresponds to a 20% concentration of the active component.
• Actovegin ointment and cream - contain 5 ml of hemoderivative (0.2 g in dried form) in 100 ml of ointment or cream, which corresponds to 5% concentration of the active component.
• Solution for infusion in dextrose - contains 25 ml of hemoderivate (1 g in dried form) per 250 ml of ready-to-use solution, which corresponds to a concentration of the active component of 4 mg/ml or 10%.
• Solution for infusion in 0.9% sodium chloride - contains 25 ml (1 g dried) or 50 ml (2 g dried) hemoderivate per 250 ml ready-to-use solution, which corresponds to a concentration of the active component of 4 mg/ml ( 10%) or 8 mg/ml (20%).
• Solution for injection – contains 40 mg of dry hemoderivate per 1 ml (40 mg/ml). The solution is available in ampoules of 2 ml, 5 ml and 10 ml. Accordingly, ampoules with 2 ml of solution contain 80 mg of the active component, with 5 ml of solution - 200 mg and with 10 ml of solution - 400 mg.
• Tablets for oral administration contain 200 mg of dry hemoderivate.

All dosage forms of Actovegin (ointment, cream, gel, solutions for infusion, solutions for injection and tablets) are ready for use and do not require any preparation before use. This means that the ointment, gel or cream can be applied immediately after opening the package; the tablets can be taken without preparation. Solutions for infusion are administered intravenously (“dropper”) without prior dilution and preparation, simply by placing the bottle in the system. And solutions for injection are also administered intramuscularly, intravenously or intraarterially without prior dilution, simply by selecting an ampoule with the required number of milliliters.

• Mountain wax glycolate;
• Titanium dioxide;
• Diethyl phthalate;
• Dried gum arabic;
• Macrogol 6000;
• Microcrystalline cellulose;
• Povidone K90 and K30;
• Sucrose;
• Magnesium stearate;
• Talc;
• Dye quinoline yellow aluminum varnish (E104);
• Hypromellose phthalate.

The composition of the auxiliary components of Actovegin gel, ointment and cream is shown in the table below:

Actovegin cream, ointment and gel are available in aluminum tubes of 20 g, 30 g, 50 g and 100 g. The cream and ointment are a homogeneous white mass. Actovegin gel is a transparent yellowish or colorless homogeneous mass.

Volume of Actovegin ampoules in ml

Actovegin solution in ampoules is intended for intravenous, intraarterial and intramuscular injections. The solution in ampoules is ready for use, so to make an injection you just need to open the ampoule and draw the medicine into the syringe.

Therapeutic effect

Actovegin is a universal stimulator of metabolism, which leads to a significant improvement in tissue nutrition and utilization of glucose from the blood for the needs of cells of all organs. In addition, Actovegin increases the resistance of cells of all organs and tissues to hypoxia, as a result of which, even under conditions of oxygen starvation, damage to cellular structures is minimally expressed. The general, cumulative effect of Actovegin is to enhance the production of energy molecules (ATP), necessary for the occurrence of all vital processes in the cells of any organ.

• The healing of any tissue damage (wounds, cuts, cuts, abrasions, burns, ulcers, etc.) and restoration of their normal structure are accelerated. That is, under the influence of Actovegin, any wounds heal easier and faster, and the scar forms small and unnoticeable.
• The process of tissue respiration is activated, which leads to a more complete and rational use of oxygen delivered with blood to the cells of all organs and tissues. Due to more complete use of oxygen, the negative consequences of insufficient blood supply to tissues are reduced.
• The process of glucose use by cells in a state of oxygen starvation or metabolic exhaustion is stimulated. This means that, on the one hand, the concentration of glucose in the blood decreases, and on the other, tissue hypoxia decreases due to the active use of glucose for tissue respiration.
• The synthesis of collagen fibers improves.
• The process of cell division is stimulated with their subsequent migration to areas where tissue integrity needs to be restored.
• The growth of blood vessels is stimulated, which leads to improved blood supply to tissues.

The effect of Actovegin in enhancing the utilization of glucose is very important for the brain, since its structures need this substance more than all other organs and tissues of the human body. After all, the brain uses mainly glucose to produce energy. Actovegin contains inositol phosphate oligosaccharides, the effect of which is similar to that of insulin. This means that under the influence of Actovegin, the transport of glucose into the tissues of the brain and other organs improves, and then this substance is quickly captured by cells and utilized for energy production. Thus, Actovegin improves energy exchange in the structures of the brain and meets its needs for glucose, thereby normalizing the functioning of all parts of the central nervous system and reducing the severity of cerebral insufficiency syndrome (dementia).

Indications for use (Why is Actovegin prescribed?)

Various dosage forms of Actovegin are indicated for use in different diseases, so to avoid confusion, we will consider them separately.

• Acceleration of wound healing and inflammatory processes on the skin and mucous membranes (abrasions, cuts, scratches, burns, cracks);
• Improving tissue restoration after burns of any origin (hot water, steam, solar, etc.);
• Treatment of weeping skin ulcers of any origin (including varicose ulcers);
• Prevention and treatment of reactions to the effects of radiation exposure (including radiation therapy of tumors) on the skin and mucous membranes;
• Prevention and treatment of bedsores (only for Actovegin ointment and cream);
• For pre-treatment of wound surfaces before skin grafting during the treatment of extensive and severe burns (only for Actovegin gel).

Solutions for infusions and solution for injections (injections) Actovegin - indications for use. Solutions for infusions (“droppers”) and solutions for injections are indicated for use in the same following cases:

• Treatment of metabolic and vascular disorders of the brain (for example, ischemic stroke, consequences of traumatic brain injury, impaired blood flow in the structures of the brain, as well as dementia and disorders of memory, attention, ability to analyze due to vascular diseases of the central nervous system, etc.);
• Treatment of peripheral vascular disorders, as well as their consequences and complications (for example, trophic ulcers, angiopathy, endarteritis, etc.);
• Treatment of diabetic polyneuropathy;
• Healing of wounds of the skin and mucous membranes of any nature and origin (for example, abrasions, cuts, incisions, burns, bedsores, ulcers, etc.);
• Prevention and treatment of lesions of the skin and mucous membranes due to exposure to radiation, including radiation therapy of malignant tumors;
• Treatment of thermal and chemical burns (only for injection solutions);

Actovegin tablets – indications for use. The tablets are indicated for use in the treatment of the following conditions or diseases:

• As part of complex therapy for metabolic and vascular diseases of the brain (for example, cerebrovascular insufficiency, traumatic brain injury, as well as dementia due to vascular and metabolic disorders);
• Treatment of peripheral vascular disorders and their complications (trophic ulcers, angiopathy);
• Diabetic polyneuropathy;
• Hypoxia of organs and tissues of any origin (this indication is approved only in the Republic of Kazakhstan).

Instructions for use

Actovegin ointment, cream and gel - instructions for use

Various dosage forms of Actovegin for external use (gel, cream and ointment) are used for the same conditions, but at different stages of these diseases. This is due to various auxiliary components that give different properties to the gel, ointment and cream. Therefore, gel, cream and ointment provide scarring of wounds at different stages of healing with different types of wound surfaces.

• If the wound is wet with copious discharge, then the gel should be used until the wound surface dries. When the wound dries, you need to switch to using a cream or ointment.
• If the wound is moderately wet, the discharge is scanty or moderate, then you should use a cream, and after the wound surface has completely dried, switch to using an ointment.
• If the wound is dry, without discharge, then ointment should be used.

Rules for treating wounds with Actovegin gel, cream and ointment

Actovegin tablets - instructions for use (adults, children)

Tablets are intended for use for the same conditions and diseases as solutions for injection. However, the severity of the therapeutic effect with parenteral administration of Actovegin (injections and “droppers”) is stronger than when taking the drug in tablet form. That is why many doctors always recommend starting treatment with parenteral administration of Actovegin, followed by switching to taking tablets as consolidation therapy. That is, at the first stage of therapy, in order to quickly achieve the most pronounced therapeutic effect, it is recommended to administer Actovegin parenterally (injections or “droppers”), and then additionally drink the drug in tablets to consolidate the effect achieved by injections for a long period of time.

Actovegin injections - instructions for use

Dosages and general rules for using Actovegin solutions

Figure 2 - Correctly breaking off the tip of the ampoule to open it.

• Metabolic and vascular disorders of the brain (traumatic brain injury, cerebrovascular insufficiency) - administer 5-25 ml of solution per day every day for two weeks. After completing the course of Actovegin injections, they switch to taking the drug in tablets in order to maintain and consolidate the achieved therapeutic effect. In addition, instead of switching to maintenance use of the drug in tablets, you can continue injecting Actovegin by injecting 5-10 ml of solution intravenously 3-4 times a week for two weeks.
• Ischemic stroke - Actovegin is administered by infusion (“dropper”), adding 20–50 ml of solution from ampoules to 200–300 ml of saline or 5% dextrose solution. At this dosage, the drug is administered by infusion every day for a week. Then, 10–20 ml of Actovegin solution from ampoules are added to 200–300 ml of infusion solution (saline or dextrose 5%) and administered in this dosage daily in the form of “droppers” for another two weeks. After completing the course of “droppers” with Actovegin, they switch to taking the drug in tablet form.
• Angiopathy (peripheral vascular disorders and their complications, for example, trophic ulcers) - Actovegin is administered by infusion (“dropper”), adding 20–30 ml of solution from ampoules to 200 ml of saline or 5% dextrose solution. At this dosage, the drug is administered intravenously every day for four weeks.
• Diabetic polyneuropathy - Actovegin is administered intravenously, 50 ml of solution from ampoules, daily for three weeks. After completing the course of injections, they switch to taking Actovegin in tablet form for 4 to 5 months to maintain the achieved therapeutic effect.
• Healing of wounds, ulcers, burns and other wound damage to the skin - a solution is administered from ampoules of 10 ml intravenously or 5 ml intramuscularly either daily or 3-4 times a week, depending on the speed of healing of the defect. In addition to injections, Actovegin can be used in the form of ointment, cream or gel to accelerate wound healing.
• Prevention and treatment of radiation injuries (during radiation therapy of tumors) of the skin and mucous membranes - Actovegin is administered 5 ml of solution from ampoules intravenously daily, in between radiation therapy sessions.
• Radiation cystitis - 10 ml of solution from ampoules is administered transurethrally (through the urethra) daily. Actovegin in this case is used in combination with antibiotics.

Rules for administering Actovegin intramuscularly

Actovegin solution for infusion - instructions for use

Actovegin infusion solutions are available in two varieties - saline solution or dextrose solution. There is no fundamental difference between them, so you can use any version of the finished solution. Such Actovegin solutions are available in 250 ml bottles in a form ready for infusion administration (“droppers”). Solutions for infusion are administered intravenously (dropper) or intra-arterially by stream (from a syringe, as intramuscularly). Injection into a vein should be carried out at a rate of 2 ml/min.

• Circulatory and metabolic disorders in the brain (traumatic brain injury, insufficient blood supply to the brain, etc.) - administer 250 - 500 ml (1 - 2 bottles) once a day every day for 2 - 4 weeks. Then, if necessary, in order to consolidate the obtained therapeutic effect, they switch to taking Actovegin tablets, or continue to administer the solution intravenously, 250 ml (1 bottle) 2-3 times a week for another 2 weeks.
• Acute cerebrovascular accidents (stroke, etc.) – administer 250–500 ml (1–2 bottles) once a day daily, or 3–4 times a week for 2–3 weeks. Next, if necessary, they switch to taking Actovegin tablets in order to consolidate the resulting therapeutic effect.
• Angiopathy (impaired peripheral circulation and its complications, for example, trophic ulcers) - administer 250 ml (1 bottle) once a day every day, or 3 to 4 times a week for 3 weeks. Simultaneously with the “droppers”, Actovegin can be used externally in the form of an ointment, cream or gel.
• Diabetic polyneuropathy - administer 250 - 500 ml (1 - 2 bottles) once a day daily, or 3 - 4 times a week for 3 weeks. Next, be sure to switch to taking Actovegin tablets in order to consolidate the resulting therapeutic effect.
• Trophic and other ulcers, as well as long-term non-healing wounds of any origin - administer 250 ml (1 bottle) once a day every day, or 3-4 times a week, until the wound defect is completely healed. Simultaneously with infusion administration, Actovegin can be used topically in the form of a gel, cream or ointment to accelerate wound healing.
• Prevention and treatment of radiation damage (during radiation therapy of tumors) of the skin and mucous membranes - administer 250 ml (1 bottle) one day before, and then daily throughout the course of radiation therapy, and also for an additional two weeks after last irradiation session.

special instructions

With repeated intravenous, intramuscular or intra-arterial administration of Actovegin, the level of blood electrolytes (calcium, potassium, sodium, chlorine) and the percentage of water in the body (hematocrit) should be monitored.

Overdose

In the Russian official instructions for use there are no indications of the possibility of overdose with any dosage forms of Actovegin. However, the instructions approved by the Ministry of Health of Kazakhstan indicate that when using Actovegin tablets and solutions, an overdose may occur, which is manifested by pain in the stomach or increased side effects. In such cases, it is recommended to discontinue use of the drug, perform gastric lavage and carry out symptomatic therapy aimed at maintaining the normal functioning of vital organs and systems.

Impact on the ability to operate machinery

Not a single dosage form of Actovegin (ointment, cream, gel, tablets, solutions for injections and solutions for infusions) affects the ability to control mechanisms, therefore, while using the drug in any form, a person can engage in any type of activity, including those requiring high speed of reactions and concentration of attention.

Interaction with other drugs

Forms of Actovegin for external use (gel, cream and ointment) do not interact with other drugs. Therefore, they can be used in combination with any other means, both for oral administration (tablets, capsules) and for local use (creams, ointments, etc.). Only if Actovegin is used in combination with other external agents (ointments, creams, lotions, etc.), a half-hour interval should be maintained between applications of the two drugs, and not applied immediately after each other.