Analgin (500 mg, Khimfarm AO). Analgin (500 mg) Analgin 500 mg instructions for use in adults

Instruction

Non-narcotic analgesic drug Analgin 500 is used in emergency conditions in adults and children. The medication is combined with antihistamines, antipsychotics and tranquilizers.

Pharmacological group

The drug belongs to the class of pyrazolones. The original international proprietary name is Metamizole sodium. The drug is prohibited for use in global medical practice.

Forms of release and composition

The antipyretic consists of the active substance Metamizolum natrium. The drug is produced in the form of tablets of 0.25 and 0.5 g, ampoules of 25% and 50% solution containing 1.2, 5 ml. The analgesic bufus is a liquid for intramuscular or intravenous administration at 500 mg / ml.

In a cardboard box with ampoules with a capacity of 2 ml there is a special file for opening. For intravenous administration, a solution is released in polyethylene ampoules of 2 ml.

The analgesic bufus is a liquid for intramuscular or intravenous administration at 500 mg / ml.

The anesthetic Ultra is produced in the form of film-coated tablets at a dose of 500 mg. The medicine is in the cells of the contour packaging.

Mechanism of action

The drug from the group of pyrazolones produces the following pharmacological effects:

• biochemical;
• physical and chemical;
• physical.

Pharmacodynamics

The antipyretic affects the formation of cyclooxygenase enzymes. Metamizole sodium blocks the isoenzyme production, reduces the amount of leukotrienes involved in the synthesis of internal opioids.

After taking an analgesic, the concentration of dynorphin and beta-endorphin in tissues decreases. In this case, the analgesic effect of metamizole sodium increases. Doses greater than 500 mg are effective in reducing trauma pain.

Pharmacokinetics

After introduction into the body, the analgesic enters the liver and decomposes, forming several metabolites: 4-methylaminoantipyrine and 4-aminoantipyrine. In the patient's blood, the drug remains in its original form.

If the concentration of metabolites exceeds 20 μg / ml, the toxic effect of the analgesic is manifested. The drug does not accumulate in the body. The half-life is 2.5 hours.

The decay products of the active substance are excreted in the urine. Constant pharmacokinetics is observed in the following groups of patients: in children from 3 years old, the elderly from 70 and older, pregnant patients.

Indications for use

An anesthetic helps a person reduce the manifestations of chronic pain syndrome in stage III-IV cancers. The intensity of acute pain at the initial stage of the development of a malignant tumor is also reduced with metamizole sodium.

The drug is used in cases where the patient is contraindicated in taking NSAIDs.

The indications for prescribing the drug are:

• algomenorrhea syndrome;
• increase in body temperature;
• acute pancreatitis;
• post-traumatic and postoperative syndromes.

Acute pancreatitis is one of the indications for the use of Analgin.

Taking metamizole sodium should correspond to the intensity of pain, not pose a threat to human health.

An antipyretic is often used to reduce fever. The analgesic does not reduce the duration of hyperthermia in ARVI. It is not recommended to regularly take painkillers, even if the temperature has reached high numbers. In this case, it is reduced with the help of other recommended drugs. The drug eliminates inflammation, but its use is limited in children. In some cases, it causes collapse and a decrease in temperature to +34.5 ... + 35 ° С.

The drug is used in psychiatry to eliminate conditions that pose a threat to the health and life of the patient. In some patients, an analgesic drug is used in the complex therapy of osteoporosis, combined with the use of ointments and gels.

Contraindications

The drug is not prescribed to a patient who has concomitant diseases:

• glomerulonephritis;
• stomach ulcer;
• arrhythmia;
• diseases of the circulatory system.

Patients suffering from concomitant vascular pathology are at risk of developing myocardial infarction, thromboembolism with prolonged use of high doses of metamizole sodium.

The tablets are hepatotoxic. The drug is not prescribed for the treatment of patients with a history of attacks of renal colic. Acute abdominal pain is an absolute contraindication for the appointment of an analgesic.

The drug has an adverse effect on the patient's body:

• increases cardiac output;
• provokes the development of myocardial ischemia;
• activates the sympathetic nervous system;
• contributes to the development of hypostatic pneumonia;
• leads to urinary retention.

Method of application and dosage of Analgin 500

The drug is taken ½ tablet 2-3 times a day after meals or injected into a muscle (vein), 2.0 ml 3 times a day.

Adults

Tablets are taken 250-500 mg 2-3 times a day. The dose should not exceed 1.0 g. Intramuscularly or intravenously slowly, the drug is administered to an adult at 500 mg 3 times a day. The daily dose of the analgesic is 2 g. The medicine is drunk after meals. In case of treatment for more than 7 days, the state of the liver is monitored.

children

Metamizole sodium is prescribed in the form of suppositories from 3 months of age. The medicine should not be taken regularly, because the drug has many side effects.

The child is prescribed 10 mg / kg 3 times a day for several days if it is necessary to quickly reduce the temperature.

Side effects and overdose

After taking an analgesic, the patient often develops interstitial nephritis. Its appearance is associated with the body's response to the introduction of a chemical compound. Agranulocytosis is manifested by a decrease in leukocytes less than 1x109 / l.

Often the patient is concerned about the following symptoms:

• arterial hypotension;
• violation of the heart rhythm;
• myocarditis;
• dyspnea.

The use of the drug in a high dose causes the development of inflammation. The skin rash occurs after a previous period of sensitization.

On ECT, a violation of the heart rhythm is recorded. Myocarditis is drug-induced in nature, accompanied by the formation of an antigen-antibody complex. The patient has shortness of breath, swelling of the legs, tachycardia, symptoms of heart failure.

Often the patient is tormented by nausea after eating, a feeling of heaviness and pain in the epigastric region. The attack ends with profuse repeated vomiting.

After the use of an anesthetic drug, angioedema develops - an acute condition, accompanied by changes in the subcutaneous tissue and skin. Patients note its appearance on the mucous membrane of the cheeks, eyelids, and lips.

At the same time, unpleasant symptoms occur:

• abdominal pain;
• violation of the chair;
• dizziness;
• change in breathing;
• hoarseness of voice.

Dizziness is one of the side effects of taking the drug.

Special instructions Analgin 500

During treatment, it is necessary to control the blood test. It is not recommended to take pills with acute abdominal pain. Often during therapy, urine turns bright red.

During pregnancy and lactation

The anesthetic penetrates the placental barrier and adversely affects the fetus. The use of an analgesic in late pregnancy weakens labor, causes pulmonary hypertension and bleeding in the fetus.

After taking an anesthetic for a severe toxic form of influenza, the following symptoms appear in a pregnant woman:

• convulsions;
• speech disorder;
• bradycardia;

In case of incomplete spontaneous miscarriage, rectal suppositories containing metamizole sodium are prescribed to eliminate pain.

In childhood

• agronulocytosis;
• anaphylactic shock;
• changes in the walls of blood vessels;
• lowering blood pressure.

The drug has a negative effect on the work of the stomach and intestines. The child develops inflammation or bleeding.

If it is impossible to use Ibuprofen or Paracetamol during fever (intolerance, diarrhea, vomiting), or the patient has developed a hyperthermic syndrome, an antipyretic is administered parenterally.

A single dose of the drug should not exceed 5 mg / year (0.02 ml of solution per year of the patient's life). In older children, the amount of the drug is 50-75 mg / year (0.1-0.15 ml of a 50% solution).

An antipyretic is administered immediately if the child's health worsens, chills, muscle pain appear; he refuses to drink.

In old age

There are restrictions on the use of metamizole sodium in the elderly:

• pain syndrome in osteoarthritis;
• hypertension;
• heart failure.

An overdose causes the appearance of undesirable reactions from the central nervous system and liver. Sometimes death occurs.

When using the maximum daily dose, the risk of chronic intoxication increases. For pain relief in the postoperative period, metamizole sodium is often prescribed. After its use, the patient may experience gastric bleeding.

The drug is prescribed taking into account the severity of the surgical intervention and the presence of concomitant pathology.

For impaired renal function

With renal colic, tablets are used with caution if the patient has symptoms of a functional disorder of the urinary organ:

• swelling;
• tissue hypoxia;
• reduction in the size of the distal tubules.

Pyelonephritis is manifested by pain and intoxication, but taking an anesthetic drug worsens the prognosis in elderly and senile people.

For impaired liver function

For the treatment of hepatic porphyria, the drug is contraindicated, since the tablets cause an exacerbation of the pathological process. A great danger is the simultaneous use of an analgesic and alcoholic beverages.

In a patient with erythropoietic uroporphyria, after taking an analgesic, the level of free bilirubin in the blood serum increases. The use of metamizole sodium leads to a deterioration in the patient's condition, the appearance of sclerotic skin on the face. Do not prescribe medicine to a patient with a liver cyst.

Influence on concentration

Drug interaction Analgin 500

When used simultaneously with myotropic antispasmodics, the analgesic eliminates the symptoms of renal or hepatic colic.

With other drugs

To reduce the intensity of the headache, the drug is combined with drugs such as:

• Codeine;
• Caffeine;
• Paracetamol;
• Phenobarbital.

The use of an anesthetic drug with other drugs causes side effects. The analgesic enhances the effect of drugs that lower blood sugar levels.

Tranquilizers increase the concentration of metamizole sodium in serum. The effectiveness of the pain reliever is reduced when taken with contraceptives.

Alcohol compatibility

The patient has symptoms of intoxication:

• vomit;
• fear;
• headache.

Large doses of painkillers and alcohol cause acute poisoning.

Terms and conditions of storage

The drug should be kept in a dry and cool place at an air temperature not higher than +15…+25°С.

Terms of dispensing from pharmacies

Are they sold without a prescription?

Metamizole sodium tablets are commercially available.

What is the price

Pharmacies sell the drug for 8 rubles. for 1 pack of 10 tablets. A box of injectables costs 85 rubles. The price of tablets from other manufacturers and under other names is 58 rubles. for packing.

Analogues

Sometimes it becomes necessary to replace a previously prescribed drug with a drug that has a similar effect.

• Novalgin;
• Pentalgin;
• Dipyrone;
• Ronalgin;
• Sibalgin;
• Totalgin;
• Cimapiril.

Pentalgin is one of the analogues of Analgin.

Revalgin is produced in India. The price of 10 tablets is 37 rubles. The drug has age restrictions.

Panadol Extra is used to treat pain, neuralgia, as an antipyretic for influenza.

Analgin

tablets 500 mg; contour packaging without cells 10; № Р N000351/01, 2008-02-26 from Organika (Russia)

Latin name

analgin

Active substance

Metamizole sodium*(Metamizolum natrium)

ATH:

N02BB02 Metamizole sodium

Pharmacological group

NSAIDs - Pyrazolones

Indications

Arthralgia, rheumatism, chorea, pain: headache, dental, menstrual, neuralgia, sciatica, myalgia, colic (renal, hepatic, intestinal), pulmonary infarction, myocardial infarction, dissecting aortic aneurysm, thrombosis of the main vessels, inflammatory processes (pleurisy, pneumonia , lumbago, myocarditis), trauma, burns, decompression sickness, herpes zoster, tumors, orchitis, pancreatitis, peritonitis, esophageal perforation, pneumothorax, post-transfusion complications, priapism; febrile syndrome in acute infectious, purulent and urological diseases (prostatitis), insect bites (including mosquitoes, bees, gadflies).

Contraindications

Hypersensitivity, oppression of hematopoiesis (agranulocytosis, cytostatic or infectious neutropenia), severe violations of the liver or kidneys, prostaglandin bronchial asthma, hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase, pregnancy, lactation.

Use during pregnancy and lactation

Side effects

Granulocytopenia, agranulocytosis, thrombocytopenia, hemorrhages, hypotension, interstitial nephritis, allergic reactions (including Stevens-Johnson, Lyell syndromes, bronchospasm, anaphylactic shock).

Precautionary measures

Medical supervision is required (high frequency of allergic reactions, including fatal ones, especially when administered parenterally). Regular long-term use is not recommended due to myelotoxicity. Use for relieving acute pain in the abdomen is excluded (until the cause is clarified). When administered to patients with acute cardiovascular pathology, careful monitoring of hemodynamics is necessary. Use with caution in patients with SBP levels below 100 mm Hg. Art., with anamnestic indications of kidney disease (pyelonephritis, glomerulonephritis) and with a long history of alcohol.

special instructions

When using metamizole sodium, red staining of urine is possible due to the release of a metabolite.

Storage conditions of the drug Analgin

In a place protected from light, at a temperature not exceeding 30 ° C.

Keep out of the reach of children.

Shelf life of the drug Analgin

5 years.

Do not use after the expiry date stated on the packaging.

2000-2015. Register of Medicinal Products of Russia
The database is intended for healthcare professionals.
Commercial use of materials is not permitted.

Possible product names

• Analgin tab.500mg №10
• ANALGIN 500 MG TAB. #10
• ANALGIN 0.5 N10 TABLE
• ANALGIN TABLE 500 MG X10
• ANALGIN TAB. 500MG #10
• NB.Analgin 0.5 Tab. x10
• (Analgini) Analgin tab. 500mg №10

Analgin

International non-proprietary name

Metamizole sodium

Dosage form

Tablets 500 mg

Compound

One tablet contains:

active substance- metamizole sodium 500.0 mg,

Excipients: sucrose, talc, potato starch, calcium stearate.

Description

Tablets are white or white with a slightly yellowish tinge of color, flat-cylindrical shape with a chamfer and a risk.

Farmacotherapeutic group

Other analgesics-antipyretics. Pyrazolones. Metamizole sodium

ATX code N02BB02

Pharmacological properties

Pharmacokinetics

When taken orally, it is rapidly and completely absorbed. There is no unchanged metamizole in the blood.

Excreted by the kidneys as metabolites. Metabolites are excreted in breast milk. The action develops in 20-40 minutes and reaches a maximum after 2 hours. The maximum concentration is reached 1-1.5 hours after parenteral administration. The half-life is about 7 hours. Metabolites are completely excreted in the urine, 71% of the administered dose is found in the range from 0 to 24 hours, 18% - from 24 to 48 hours.

Pharmacodynamics

Analgin has an analgesic, antipyretic and weak anti-inflammatory effect. It is a derivative of pyrazolone. The mechanism of action is associated with inhibition of the activity of cyclooxygenase types I and II. As a result, the reactions of the arachidonic cascade of eicosanoid synthesis are blocked and the formation of prostaglandins PgE2, PgF2α, their endoperoxides, and bradykinin is disrupted. In the nuclei of the antinociceptive system, analgin enhances the release of kynurenic acid, which inhibits the conduction of pain impulses (due to the effect on NMDA receptors).

It prevents the conduction of pain impulses from extra- and proprioceptive receptors along the Gaulle and Burdach bundles, increases the excitability threshold of the pain centers of the thalamus. At the same time, it enhances heat transfer, reduces the activity of the hypothalamic thermosetting center.

Indications for use

Pain syndrome, mild or moderate (headache, toothache, neuralgia, myalgia, dysmenorrhea, postoperative pain)

Fever in infectious and inflammatory diseases

Dosage and administration

1 tablet 2-3 times a day after meals. The maximum single dose is 1 g, the daily dose is 3 g. Adults and children over 15 years of age are prescribed 250-500 mg (½-1 tablet) 2-3 times a day.

The duration of admission is not more than 5 days when prescribed as an anesthetic and not more than 3 days as an antipyretic.

Side effects

Rarely

Nausea, vomiting, anorexia, epigastric pain, flatulence,

constipation, diarrhea

Headache, dizziness, agitation, irritability

Allergic reactions (skin rash, itching, angioedema),

erythema multiforme exudative (Stevens-Johnson syndrome),

toxic epidermal necrolysis (Lyell's syndrome),

bronchospastic syndrome, anaphylactic shock

Paresthesia, tinnitus, blurred vision, tremor, depression

Agranulocytosis, leukopenia, anemia, thrombocytopenia (with prolonged

application)

Arterial hypotension, cardiac arrhythmias

Oliguria, anuria, proteinuria, impaired renal function,

interstitial nephritis

Contraindications

Hypersensitivity to analgin, other derivatives

pyrazolone (phenylbutazone, tribuzone) or other auxiliary

drug substances

Glucose-6-phosphate dehydrogenase deficiency

Liver and/or kidney failure

Inhibition of hematopoiesis (agranulocytosis, cytotoxic or

infectious neutropenia), anemia, leukopenia

Peptic ulcer of the stomach and duodenum, gastrointestinal

intestinal bleeding

Asthma attacks, urticaria, history of acute rhinitis,

associated with the use of acetylsalicylic acid or other

non-steroidal anti-inflammatory drugs

Children's age up to 15 years

Pregnancy and lactation

Drug Interactions

With simultaneous use with other analgesics, antipyretics and non-steroidal anti-inflammatory drugs, mutual enhancement of toxic effects is possible.

The action of Analgin is enhanced when used together with barbiturates, codeine, H2-blockers of histamine receptors, anaprilin (due to slowing down the inactivation of the drug).

Increases the risk of developing leukopenia when used together with thiamazole and cytostatic agents.

Analgin displaces oral hypoglycemic agents from their association with blood plasma proteins and, thereby, increases their effect.

Enhances the activity of indirect anticoagulants, glucocorticosteroids and indomethacin due to their displacement from the connection with plasma proteins.

Analgin enhances the sedative effect of ethyl alcohol.

Analgin lowers the concentration of cyclosporine A in the blood plasma.

With simultaneous use with phenothiazine derivatives, severe hyperthermia may develop.

Tricyclic antidepressants, combined oral contraceptives and allopurinol slow down the metabolism of Analgin and increase its toxicity, sedatives and anxiolytics enhance the analgesic effect of Analgin.

With simultaneous use with myotropic antispasmodics (drotaverine, papaverine, pitofenone) and m-anticholinergics (fenpiverinium bromide, platifillin, atropine), a mutual enhancement of the analgesic, antispasmodic and antipyretic activity of this combination is observed.

Caffeine enhances the effect of the drug.

With simultaneous use with inducers of microsomal liver enzymes, the effectiveness of Analgin may decrease.

special instructions

Long-term use of Analgin

If it is necessary to regularly use Analgin for more than 5 days, the picture of peripheral blood should be monitored weekly.

Use in individuals with pathology of the cardiovascular system

Careful monitoring of hemodynamics is necessary, especially in patients with systolic pressure levels below 100 mm Hg. Art. or with circulatory instability (for example, with myocardial infarction, multiple trauma, incipient shock), with a history of kidney disease (pyelonephritis, glomerulonephritis), as well as in people with alcohol dependence.

Agranulocytosis

In the event of an unexpected deterioration in the general condition of the patient during treatment with Analgin, manifested by fever, inflammation of the mucous membranes of the oral cavity and pharynx (necrotizing stomatitis, purulent-necrotic tonsillitis), nose (sinusitis), increased ESR, the drug should be stopped immediately, because . these symptoms may be associated with the development of agranulocytosis.

Excretion with urine of biotransformation products Analgin can cause red staining of urine, which has no clinical significance and disappears after discontinuation of the drug.

Application in pediatrics

Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

Receiving Analgin does not affect the ability to drive vehicles or potentially dangerous mechanisms, but care should be taken with prolonged use.

Overdose

Symptoms: nausea, vomiting, stomach pain, hypothermia, lowering blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, impaired consciousness, delirium, acute liver and / or kidney failure, convulsions, paralysis of the respiratory muscles, agranulocytosis.

Treatment: withdrawal of the drug, gastric lavage, taking saline laxatives and activated charcoal to prevent absorption of the drug in the stomach and intestines, symptomatic therapy aimed at maintaining vital functions. Carrying out forced diuresis and the introduction of sodium bicarbonate in order to alkalinize urine accelerate the excretion of the drug. There is no specific antidote for metamizole sodium. The main metabolite of metamizole (4-methylaminoantipyrine) can be removed by hemodialysis, hemofiltration, hemoperfusion and plasmapheresis. With the development of a convulsive syndrome - intravenous administration of diazepam and high-speed barbiturates.

in a contour non-cell or cell package of 10 pcs.; in a cardboard pack 1, 2, 3 or 5 packs.

Description of the dosage form

Tablets are white or slightly yellowish, flat-cylindrical, scored and chamfered, with a bitter taste.

Pharmacodynamics

Metamizole sodium is a derivative of pyrazolone. It has analgesic, antipyretic and weak anti-inflammatory effects, the mechanism of which is associated with inhibition of PG synthesis. Pharmacological action develops 20-40 minutes after taking the drug and reaches a maximum after 2 hours.

Analgin: Indications

Pain syndrome of various etiologies:

headache;

migraine pain;

toothache;

neuralgia;

algomenorrhea;

postoperative pain;

renal and biliary colic (in combination with antispasmodics);

febrile conditions in infectious and inflammatory diseases.

Analgin: Contraindications

hypersensitivity to pyrazolone derivatives (butadione, tribuzone);

bronchial asthma;

diseases accompanied by bronchospasm;

"aspirin asthma";

oppression of hematopoiesis (agranulocytosis, neutropenia, leukopenia);

severe violations of the liver or kidneys;

blood diseases;

hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase;

pregnancy (especially in the first trimester and in the last 6 weeks);

lactation period.

With caution - infancy (up to 3 months).

Use during pregnancy and lactation

Contraindicated in pregnancy (especially in the first trimester and in the last 6 weeks). At the time of treatment should stop breastfeeding.

Dosage and administration

inside, adults - 1 tab. 2-3 times a day after meals. The maximum single dose is 1 g (table 2), daily dose is 3 g (table 6). With prolonged (more than a week) use of the drug, it is necessary to control the pattern of peripheral blood and the functional state of the liver.

Children are prescribed 5–10 mg/kg of body weight 3–4 times a day for no more than 3 days (after crushing the tablet).

Do not use (without consulting a doctor) for more than 3 days when prescribed as an antipyretic and for more than 5 days when prescribed as an anesthetic.

Analgin side effects

Allergic reactions: skin rash, angioedema; rarely - anaphylactic shock, toxic epidermal necrolysis (Lyell's syndrome), in rare cases - Stevens-Johnson syndrome.

With prolonged use, leukopenia, thrombocytopenia, agranulocytosis may occur.

With a tendency to bronchospasm, provoking an attack is possible; decrease in blood pressure.

Possible impaired renal function, oliguria, anuria, proteinuria, interstitial nephritis, urine staining red due to the release of a metabolite.

About all side (unusual) effects, incl. not listed above, you should inform your doctor and stop taking the drug.

Overdose

Symptoms: with prolonged use of the drug (more than 7 days) in high doses - nausea, vomiting, gastralgia, oliguria, hypothermia, decreased blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, delirium, impaired consciousness, agranulocytosis, hemorrhagic syndrome, acute renal and / or liver failure, convulsions, paralysis of the respiratory muscles.

Treatment: induce vomiting, do gastric lavage, take saline laxatives, activated charcoal. In the conditions of a medical institution - carrying out forced diuresis, hemodialysis, with the development of a convulsive syndrome - in / in the introduction of diazepam and barbiturates.

Interaction

Simultaneous use of Analgin with other non-narcotic analgesics can lead to mutual enhancement of toxic effects.

Tricyclic antidepressants, oral contraceptives, and allopurinol interfere with hepatic metabolism of metamizole and increase its toxicity.

Barbiturates and phenylbutazone weaken the action of analgin.

Analgin enhances the effects of alcoholic beverages.

Radiopaque agents, colloidal blood substitutes and penicillin should not be used during treatment with metamizole.

Metamizole, displacing oral hypoglycemic drugs, indirect anticoagulants, corticosteroids and indomethacin from the connection with the protein, increases their activity.

The simultaneous use of Analgin with cyclosporine reduces the level of the latter in the blood. Thiamazole and sarcolysin increase the risk of leukopenia. The effect is enhanced by codeine, propranolol (slows down inactivation).

Sedatives and tranquilizers enhance the analgesic effect of analgin.

special instructions

Hypersensitivity reactions may develop in patients suffering from bronchial asthma and hay fever.

With prolonged use (more than 7 days), it is necessary to control the picture of peripheral blood.

Do not use to relieve acute pain in the abdomen (until the causes are clarified).

In the treatment of children under 5 years of age and patients receiving cytostatic agents, taking metamizole sodium should be carried out only under the supervision of a physician.

Special care is required when prescribing to patients who abuse alcoholic beverages.

For children and adolescents under 18 years of age, use only as directed by a doctor.

Active substance

Metamizole sodium

Dosage form

tablets

Manufacturer

Pharmstandard, Russia

Compound

1 tablet contains:
active ingredient: metamizole sodium (analgin) 500 mg
excipients: sucrose (sugar), potato starch, talc, calcium stearate.

pharmachologic effect

Analgin non-selectively blocks cyclooxygenase and reduces the formation of prostaglandins from arachidonic acid, prevents the conduction of extra-painful and proprioceptive impulses.

Analgin has a mild anti-inflammatory effect, causing a small effect on water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa.

It has an antispasmodic effect on the smooth muscles of the urinary and biliary tract. The action develops 20-40 minutes after ingestion.

Pharmacokinetics

It is well and quickly absorbed in the gastrointestinal tract, which ensures the rapid development of the clinical effect. When taken in therapeutic doses, it passes into breast milk.

The maximum plasma concentration is reached 1-1.5 hours after ingestion.

In the intestinal wall, it is hydrolyzed to form the active metabolite, 4-methyl-amino-antipyrine, which in turn is metabolized to 4-formyl-amino-antipyrine and other metabolites.

The level of binding of the active metabolite to proteins is 50-60%.

Excretion of metabolites passes through the kidneys. In addition, metabolites are excreted in breast milk.

Indications

• pain syndrome (mild and moderate): incl. headache, migraine, toothache, neuralgia, myalgia, radicular syndrome, algomenorrhea; with renal, hepatic and biliary colic (in combination with antispasmodics),
• to reduce pain after surgical and diagnostic interventions,
• elevated body temperature with "colds" and other infectious and inflammatory diseases. The expediency of using the drug is decided in each case, depending on the severity, nature and tolerance of fever.

Contraindications

• hypersensitivity to pyrazolone derivatives (propyphenazone, phenazone or phenylbutazone);
• bronchial asthma induced by taking acetylsalicylic acid, salicylates or other non-steroidal anti-inflammatory drugs (NSAIDs);
• bronchial obstruction, rhinitis, urticaria, provoked by taking acetylsalicylic acid or other NSAIDs (including history), condition after CABG;
• oppression of hematopoiesis (agranulocytosis, cytostatic or infectious neutropenia);
• severe violations of the liver or kidneys;
• hepatic porphyria;
• confirmed hyperkalemia, erosive and ulcerative changes in the mucous membrane of the stomach and duodenum, active gastrointestinal bleeding, inflammatory bowel disease, anemia, leukopenia;
• hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase.

Side effects

In therapeutic doses, the drug is usually well tolerated.

When using Analgin tablets in some patients, adverse reactions may occur:

• allergic reactions (skin rash, Quincke's edema; rarely - anaphylactic shock);
• with prolonged use, leukopenia may occur, rarely agranulocytosis.

With a tendency to bronchospasm, provoking an attack is possible.

Possible impaired renal function.

Interaction

Due to the high likelihood of developing pharmaceutical incompatibility, it cannot be mixed with other drugs in the same syringe.

Simultaneous use of analgin with other non-narcotic analgesics can lead to mutual enhancement of toxic effects.

Tricyclic antidepressants, oral contraceptives, allopurinol disrupt the metabolism of dipyrone in the liver and increase its toxicity.

Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the action of analgin.

The simultaneous use of analgin with cyclosporine reduces the level of the latter in the blood.
Sedatives and tranquilizers enhance the analgesic effect of analgin.

How to take, course of administration and dosage

Inside, after meals, adults and children over 14 years of age are prescribed 250-500 mg 2-3 times a day, the maximum single dose is 1000 mg, the daily dose is 3000 mg.

Children 8-14 years old are prescribed 250 mg (1/2 tablet) 2-3 times a day.

The duration of admission without consulting a doctor is not more than 5 days.

Overdose

In case of overdose, you should consult your doctor.

The following symptoms may appear: nausea, vomiting, stomach pain, oliguria, hypothermia, lowering blood pressure, tachycardia, shortness of breath, tinnitus, drowsiness, delirium, impaired consciousness, acute agranulocytosis, hemorrhagic syndrome, acute renal and / or liver failure, convulsions, paralysis of the respiratory muscles.

Treatment: symptomatic. There is no specific antidote for metamizole sodium. In the conditions of a medical institution - carrying out forced diuresis, hemodialysis, with the development of a convulsive syndrome - intravenous administration of diazepam and high-speed barbiturates.

Special Instructions

Hypersensitivity reactions may develop in patients suffering from bronchial asthma and hay fever.

With prolonged use (more than 7 days), it is necessary to control the picture of peripheral blood. Against the background of taking metamizole sodium, agranulocytosis may develop, and therefore, if an unmotivated rise in temperature, chills, sore throat, difficulty swallowing, stomatitis, erosive and ulcerative lesions of the oral cavity, vaginitis or proctitis are detected, immediate withdrawal of the drug is necessary.

Do not use to relieve acute pain in the abdomen (until the causes are clarified).