Dalacin c capsules. Dalacin: instructions for use, analogues and reviews, prices in Russian pharmacies. Method of use and dosage

Instruction

Tradename

Dalacin®

International non-proprietary name

Clindamycin

Dosage form

Capsules 150 mg, 300 mg

Compound

One capsule contains:

active substance- clindamycin hydrochloride 177.515 mg or 355.030 mg (equivalent to clindamycin 150 mg or 300 mg),

Excipients: magnesium stearate, corn starch, talc, lactose monohydrate,

composition of the capsule shell: titanium dioxide (E 171), gelatin.

Description

Hard opaque gelatin capsules with a white cap and body, black ink printed with the trademark "Pfizer" and the code "Clin 150". The contents of the capsules are white powder (for a dosage of 150 mg).

Hard opaque gelatin capsules with a white cap and body, black ink printed with the Pfizer trademark and the Clin 300 code. The contents of the capsules are white powder (for a dosage of 300 mg).

Pharmacotherapeutic group

Antibacterial drugs for systemic use.

Macrolides, lincosamides and streptogramins. Lincosamides.

ATX Code: J01FF01

Pharmacological properties

Pharmacokinetics

Suction

After oral administration, clindamycin is rapidly and almost completely absorbed (90% of the dose taken).

Simultaneous ingestion of food practically does not affect the concentration of the drug in blood plasma.

Distribution

Serum concentrations

In healthy adults, peak plasma concentrations are about 2-3 mg/l and occur one hour after oral administration of 150 mg of clindamycin hydrochloride or 4-5 mg/l after oral administration of 300 mg. Then the plasma concentration slowly falls, remaining above 1 mg / l for more than 6 hours. Plasma concentration increases linearly with increasing dose. Serum concentrations are reported to be slightly lower in diabetic patients than in healthy patients. The mean biological half-life of clindamycin in serum is 2.5 hours.

Plasma protein binding

Plasma protein binding ranges from 80 to 94%.

Circulation in tissues and body fluids

Clindamycin is widely distributed in very high concentrations in extracellular and intracellular fluids and tissues. Diffusion into the cerebrospinal fluid is very limited.

Metabolism

Clindamycin is metabolized in the liver.

breeding

Approximately 10% of the drug in the active form is excreted in the urine and 3.6% is excreted in the feces. The remainder is excreted as inactive metabolites.

Serum concentrations of clindamycin do not change as a result of hemodialysis or peritoneal dialysis.

Pharmacodynamics

The following minimum inhibitory concentration (MIC) sensitivity limits serve to distinguish between susceptible organisms, organisms with intermediate susceptibility, and organisms with intermediate susceptibility from resistant organisms:

S ≤ 2 mg/l and R > 2 mg/l.

The prevalence of acquired resistance may vary for certain species depending on the geographical region and over time, and it is desirable to have information on the regional patterns of the prevalence of resistance, in particular in the treatment of severe infections. This information provides only a rough idea of ​​the likely susceptibility of organisms to a given antibiotic.

Susceptible species

Gram-positive cocci, including:

- bacillus cereus

- Corynebacterium diphtheriae

- Enterococcus faecium

- Erysipelothrix

- Staphylococcus meti- S

- Staphylococcus meti- R*

- streptococcus, not belonging to any group

- Streptococcus pneumoniae

- Streptococcus pyogenes

Gram-negative bacilli, including:

- Campylobacter

anaerobic bacteria:

- Propionibacterium acnes

- Eubacterium

- Actinomyces

- Peptostreptococcus

- Bacteroides

- Capnocytophaga

- Clostridium (Besidesperfringensanddifficile)

- Clostridium perfringens

- Fusobacterium

- Gardnerella vaginalis

- Mobiluncus

- Porphyromonas

- Prevotella

- Veillonella

Other:

- Chlamydia trachomatis

- Leptospires

- Mycoplasma hominis

- Mycoplasma pneumoniae

resistive kinds:

Gram positive aerobes

- Corynebacterium jeikeium

- Enterococci (BesidesEnterococcus faecium)

- Listeria

- Nocardia asteroids

- Rhodococcus equi

Gram negative aerobic bacteria

- Non-fermenting gram negative bacilli

- (Acinetobacter, Pseudomonasand etc.)

- Branhamella catarrhalis

- Enterobacteria

- Haemophilus

- Legionella

- Neisseria

- Pasteurella

Anaerobic bacteria

- Clostridium difficile

Other

- Mycobacteria

- Ureaplasma urealyticum

Clindamycin shows activity in vitro and in vivo against Toxoplasma gondii.

* The prevalence of resistance to methicillin is approximately 30 to 50% for all staphylococci and is observed mainly in the hospital setting.

Indications for use

Treatment

Clindamycin is indicated for the treatment of severe infections caused by susceptible organisms:

ear, nose, and throat infections;

bronchopulmonary infections;

dental infections;

skin infections;

Urogenital infections;

osteoarticular infections;

Postoperative abdominal infections;

Septicemia.

The exception is meningeal infections, even if they are caused by microorganisms susceptible to the drug, since Dalacin® does not diffuse into the cerebrospinal fluid in therapeutically effective amounts.

Dosage and administration

The drug is used orally, in order to avoid irritation of the esophagus, the capsules should be washed down with a full glass of water (250 ml).

Adult patients

The usual daily dose is 600-1800 mg/day divided into 2, 3 or 4 equal doses. The maximum daily dose is 2400 mg.

Pediatric patients

The dosage is 8-25 mg/kg per day, divided into 3 or 4 equal doses.

Use in children is indicated if they can swallow the capsule whole.

Elderly patients

Pharmacokinetic studies following oral or intravenous administration of clindamycin did not reveal clinically important differences between young and elderly patients with normal liver function and normal (adjusted for age) kidney function. In this regard, dose adjustment in elderly patients with normal liver function and normal (adjusted for age) kidney function is not required.

Patients with impaired renal function

In patients with renal insufficiency, dose adjustment of clindamycin is not required.

Patients with impaired liver function

In patients with hepatic insufficiency, dose adjustment of clindamycin is not required.

Dosage for special indications

Treatment of infections caused by beta-hemolytic streptococcus

Treatment of acute streptococcal tonsillitis or pharyngitis

Inpatient treatment of inflammatory diseases of the pelvic organs

Therapy should be started with Dalacin® C Phosphate intravenous solution (at a dose of 900 mg every 8 hours in combination with intravenous administration of an antibiotic with an appropriate spectrum of activity against gram-negative aerobic microorganisms, for example, with gentamicin at a dose of 2.0 mg / kg, followed by administration to dose of 1.5 mg/kg every 8 hours in patients with normal renal function). Intravenous administration of drugs should be continued for at least 4 days and at least 48 hours after the patient's condition improves.

Then you should continue taking Dalacin® orally at a dose of 450-600 mg every 6 hours daily until the end of the course of treatment for a total duration of 10-14 days.

Bone and joint infections

Prevention of endocarditis in patients with penicillin sensitivity

Side effects

When using Dalacin®, undesirable effects were registered, which were classified according to the frequency of their manifestation as follows: often (from ≥1/100 to< 1/10); нечасто (от ≥1/1000 до <1/100); неизвестно (невозможно определить на основании имеющихся данных).

Diarrhea, abdominal pain, pseudomembranous colitis

Deviation from the norm of biochemical indicators of liver function

Infrequently

Nausea, vomiting

Maculopapular rash, urticaria

unknown

vaginal infection

Agranulocytosis, leukopenia, neutropenia, thrombocytopenia, eosinophilia,

thrombocytopenic purpura

Hypersensitivity reactions such as angioedema and anaphylaxis in some patients allergic to penicillin, DRESS syndrome (drug hypersensitivity syndrome with eosinophilia and systemic symptoms)

Dysgeusia

Esophagitis, esophageal ulcer

Jaundice

Toxic epidermal necrolysis (Lyell's syndrome), Stevens-Johnson syndrome, exfoliative dermatitis, bullous dermatitis, morbilliform rash, acute generalized exanthematous pustulosis (AGEP), erythema multiforme, pruritus

Reporting Suspected Adverse Reactions

Reporting suspected adverse reactions after drug registration is important. This allows continued monitoring of the benefit/risk ratio of its use. All patients and healthcare professionals are asked to report any adverse reactions identified while taking Dalacin® to the address listed at the end of this package leaflet.

Contraindications

hypersensitivity to the active substance clindamycin, lincomycin or any of the excipients

children's age up to 6 years

first trimester of pregnancy and lactation

hereditary lactase deficiency, hereditary fructose intolerance, glucose/galactose malabsorption syndrome

Drug Interactions

Vitamin K antagonists

Increased antivitamin K effect and/or bleeding, more frequent monitoring of international normalized ratio (INR). If necessary, during therapy with clindamycin and after its withdrawal, adjust the dose of antivitamin K.

Means for local use in diseases of the gastrointestinal tract, antacids and adsorbents

Agents for topical use in diseases of the gastrointestinal tract, activated charcoal and antacids (salts of aluminum, calcium and magnesium) alone and in combination with alginates reduce the absorption of some other concurrently taken drugs in the gastrointestinal tract. Medicinal products with reduced absorption from the gastrointestinal tract include acetylsalicylic acid, H2 blockers and lansoprazole, bisphosphonates, cation exchangers, some classes of antibiotics (fluoroquinolones, tetracyclines and lincosamides) and some anti-tuberculosis drugs, digitalis drugs, glucocorticoids, thyroid hormones, phenothiazine antipsychotics, sulpiride, some beta-blockers, penicillamine, ions (iron, phosphorus, fluorine), chloroquine, ulipristal and fexofenadine.

As a precautionary measure, these topical gastrointestinal agents or antacids should be taken at some time interval from any other medications (more than two hours if possible).

Cyclosporine

Decrease in the blood concentration of an immunosuppressive agent, associated with the risk of loss of immunosuppressive action. Frequent monitoring of cyclosporine blood levels and, if necessary, increasing its dosage.

Tacrolimus

Decrease in the blood concentration of an immunosuppressive agent, associated with the risk of loss of immunosuppressive action. Frequent monitoring of tacrolimus blood levels and, if necessary, increasing its dosage.

Specific problems associated with changes in INR

Several cases of increased antivitamin K activity have been reported in patients treated with antibiotics. Risk factors include the severity of the infection or inflammation and the age and general condition of the patient. In such cases, it is difficult to determine whether the change in INR is caused by infection or treatment. However, some classes of antibiotics are mentioned more frequently than others in relation to this phenomenon, namely fluoroquinolones, macrolides, cyclins, cotrimoxazole, and some cephalosporins.

special instructions

antibiotic-associated colitis

Pseudomembranous colitis and antibiotic-associated colitis have been observed with almost all antibacterial agents, including clindamycin, and their severity can range from mild to life-threatening. Therefore, it is important to consider this diagnosis if diarrhea develops during or after the use of any antibiotic. If antibiotic-associated colitis develops, clindamycin should be stopped immediately; physician should be consulted and appropriate therapy initiated, including specific treatment against Clostridium difficile. In this situation, the use of drugs that suppress intestinal motility is contraindicated.

Hypersensitivity

Hypersensitivity and allergic reactions may occur, including anaphylactic reactions that can be life-threatening. In such cases, clindamycin should be discontinued and appropriate therapy instituted.

Clindamycin should be used with caution in patients with a history of asthma and other allergies.

Early onset of generalized erythema with fever and pustules may be a sign of generalized exanthematous pustulosis; therapy must be discontinued, any further use of clindamycin is contraindicated.

Impaired liver function

In case of impaired liver function, elevated serum concentrations of clindamycin and an increase in its half-life may be observed.

Long term therapy

In the case of long-term therapy, it is necessary to carefully monitor blood composition, liver enzymes and kidney function.

The use of antibiotics, especially for a long time, can lead to the emergence and selection of less susceptible bacteria or the development of fungi. In case of superinfection, appropriate therapy should be started.

Dalacin should not be used to treat meningitis because clindamycin does not penetrate sufficiently into the cerebrospinal fluid.

Lactose

Dalacin® contains lactose. Its use should be avoided in patients with lactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome (rare hereditary diseases).

Pregnancy

In embryonic studies of fetal development, no adverse effects on the fetus were observed, except when taken at doses that are toxic to the mother.

Clindamycin crosses the placenta.

Information on the effect of clindamycin when administered systemically or locally during the first trimester of pregnancy is limited.

In the available numerous data on the use of clindamycin during the second and third trimester of pregnancy, there was no increase in the incidence of congenital fetal anomalies.

Therefore, given the available data, the use of clindamycin during the first trimester of pregnancy is not recommended.

If necessary, which is determined by the attending physician, clindamycin can be used during the second and third trimesters of pregnancy.

lactation period

Clindamycin is excreted in breast milk in small concentrations. There is a risk of developing gastrointestinal disorders in infants. Therefore, as a precaution, breast-feeding should be avoided during drug therapy.

Fertility

Fertility studies in rats treated with clindamycin showed no effect of the drug on fertility or mating ability.

Features of the effect of the drug on the ability to drive vehicles and work with potentially dangerous mechanisms

Dalacin® does not affect the ability to drive vehicles and work with mechanisms or affects it to a small extent.

Overdose

Hemodialysis and peritoneal dialysis are ineffective in removing clindamycin from the blood serum.

Release form and packaging

**** *ECZACIBASI* PFIZER PHARMACIA & UPJOHN UPJOHN CO. UPJOHN PUURS S.A Pfizer MFG.Belgium N.V. Saniko N.B. (B) Pharmacy and Upjohn Company Pharmacy and Upjohn N.V./S.A Pharmacy N.V/S.A (Belgium), manufactured by Vetter Pharm

Country of origin

Belgium UNITED STATES

Product group

Antibacterial drugs

Antibiotic for local use in gynecology

Release forms

• 3 - strips (1) complete with a plastic applicator - packs of cardboard. 30 g - (1) - packs of cardboard. Vaginal cream 2% - 20 g of cream in a tube. 1 tube of 20 g complete with 3 applicators with instructions for use in a cardboard box. Vaginal cream 2% - 40 g of cream in a tube. 1 tube of 40 g complete with 7 applicators with instructions for use in a cardboard box.

Description of the dosage form

• White cream. White cream. Gel for external use 1% Vaginal suppositories solid

pharmachologic effect

Antibiotic of the lincosamide group for topical use. The mechanism of action is associated with the suppression of protein synthesis in a microbial cell due to interaction with the 50S subunit of ribosomes. Has a bacteriostatic effect; in higher concentrations against some microorganisms - bactericidal. The drug is active against microorganisms that cause bacterial vaginosis: Gardnerella vaginalis, Mobiluncus spp., Mycoplasma hominis, Peptostreptococcus spp., Bacteroides spp.

Pharmacokinetics

After using clindamycin intravaginally at a dose of 100 mg per day once (in the form of 2% clindamycin phosphate cream) for 7 days, the serum concentration reaches a maximum approximately 10 hours (4-24 hours) after administration and averages 18 ng / day on the first day. ml (4-47 ng / ml), and on the seventh day - 25 ng / ml (6-61 ng / ml), while systemic absorption is about 4% (0.6-11%) of the administered dose. In women with bacterial vaginosis, with a similar dosing regimen, about 4% of clindamycin is absorbed (with a smaller spread of 2-8%), serum concentration reaches a maximum approximately 14 hours (4-24 hours) after administration and averages 13 ng / day on the first day. ml (6-34 ng/ml), and on the seventh day -16 ng/ml (7-26 ng/ml). The systemic effect of clindamycin when administered intravaginally is weaker than when administered orally or intravenously. After intravaginal administration of repeated doses, clindamycin almost does not accumulate in the blood. The systemic half-life is 1.5-2.6 hours. Use in elderly patients In clinical studies of clindamycin 2% vaginal cream, an insufficient number of patients aged 65 years and older participated in order to assess the difference in clinical response to therapy between this age group. and younger patients. In the available reports from clinical experience, there was no difference in the response of older patients and younger ones.

Special conditions

Before prescribing the drug, Trichomonas vaginalis, Chlamydia trachomatis, Neisseria gonorrhoeae, Candida albicans and Herpes simplex virus, which often cause vulvovaginitis, should be excluded using appropriate laboratory methods. Intravaginal use of clindamycin may lead to overgrowth of non-susceptible organisms, especially yeast-like fungi. The use of clindamycin (like almost all antibiotics) orally or parenterally is associated with the development of severe diarrhea and, in some cases, pseudomembranous colitis. With the development of severe or prolonged diarrhea, the drug should be discontinued and, if necessary, appropriate diagnostic and therapeutic measures should be taken. Patients should be warned that during therapy with the drug should not have sexual intercourse, as well as use other means for intravaginal administration (tampons, douching). It is not recommended to use the drug Dalacin® cream during menstruation. It is necessary to postpone the start of therapy until the end of menstruation. The drug contains components that can reduce the strength of latex or rubber products, so the use of condoms, vaginal contraceptive diaphragms and other latex products for intravaginal use during drug therapy and within 72 hours after use is not recommended. Influence on the ability to drive transport. cf. and fur.: There is no reason to believe that the use of the drug Dalacin® vaginal cream can affect the ability to drive a car and control mechanisms.

Compound

• 1 g clindamycin (in the form of phosphate) 20 mg Excipients: sorbitan monostearate, polysorbate 60, propylene glycol, stearic acid, cetostearyl alcohol, cetyl palmitate, mineral oil, benzyl alcohol, purified water. clindamycin (in the form of phosphate) 20 mg Excipients: sorbitan monostearate, polysorbate 60, propylene glycol, stearic acid, cetostearyl alcohol, cetyl palmitate, mineral oil, benzyl alcohol, purified water. clindamycin (as phosphate) 100 mg Excipients: solid fat (Witepsol H-32, mixture of triglycerides, diglycerides and monoglycerides). clindamycin 10 mg

Dalacin indications for use

• - bacterial vaginosis.

Dalacin contraindications

• - history of hypersensitivity to clindamycin or lincomycin. With caution: age up to 12 years (data on safety and efficacy are not available).

Dalacin dosage

• 1% 100mg 150mg/ml 2% 300mg/2ml, 600mg/4ml, 900mg/6ml

Dalacin side effects

• The incidence of the following side effects is less than 10%. From the reproductive system: irritation of the mucous membrane of the vulva and vagina, pain in the vagina, vaginal discharge, vaginal candidiasis, vulvovaginitis, trichomonas vaginitis, vaginal infections, menstrual disorders, uterine bleeding, abnormal delivery, endometriosis. From the urinary system: dysuria, urinary tract infections (including pyelonephritis), proteinuria. From the digestive system: generalized abdominal pain, localized abdominal pain, abdominal cramps, bloating, dyspepsia, nausea, vomiting, diarrhea, constipation, flatulence, bad breath, taste perversion. From the side of the central nervous system: dizziness, headache. Dermatological reactions: rash, itching, maculo-papular rash, erythema, skin candidiasis. Allergic reactions: urticaria. From the endocrine system: glucosuria, hyperthyroidism. On the part of the body as a whole: fungal infections, fever, pain in the side, back pain, pain in the lower abdomen, generalized pain, bacterial infections, inflammatory edema, upper respiratory tract infections, epistaxis, deviation of the results of microbiological analyzes from the norm. Local reactions: itching and pain at the injection site.

drug interaction

Cross-resistance exists between clindamycin and lincomycin. Antagonism between clindamycin and erythromycin has been demonstrated in vitro. It has been established that clindamycin, when used systemically, disrupts neuromuscular transmission and, therefore, can enhance the effect of peripherally acting muscle relaxants, so the drug should be used with caution in patients receiving drugs of this group. Combined use with other drugs for intravaginal administration is not recommended.

Overdose

With intravaginal application of Dalacin® cream, absorption of clindamycin in quantities sufficient for the development of systemic reactions is possible. Accidental ingestion of the drug into the gastrointestinal tract can also cause systemic effects similar to those that occur after oral administration of clindamycin at therapeutic doses. Possible systemic side effects include diarrhea, hemorrhagic diarrhea, including pseudomembranous colitis (see sections "Side Effects" and "Special Instructions"). Treatment: symptomatic and supportive.

Storage conditions

• keep away from children

Information provided by the State Register of Medicines.

Synonyms

• Dalacin, Dalacin C, Dalacin C phosphate, Climycin, Clindamycin, Clindafer

Dalacin is an antibiotic from the group of lincosamides with the active ingredient clindamycin.

Antibiotic for local use. The mechanism of action is associated with the suppression of protein synthesis in a microbial cell due to interaction with the 50S subunit of ribosomes. It has a bacteriostatic effect, in higher concentrations against some microorganisms - bactericidal.

It is active against streptococci, Staphylococcus aureus, Staphylococcus epidermidis, bacteroids (including fragilis bacteroids), fusobacteria, propionibacteria, eubacteria, peptococci, peptostreptococci, chlamydia, clostridium and perfringens, which is one of the causative agents of gas gangrene.

Dalacin is available as a topical gel, vaginal cream, vaginal suppositories, injection and capsules.

Indications for use

What helps Dalacin? According to the instructions, capsules are prescribed in the following cases:

• Scarlet fever, inflammation of the middle ear;
• Upper respiratory tract infections, including pharyngitis, tonsillitis, sinusitis;
• Infectious diseases of soft tissues and skin, including furunculosis, impetigo, acne, subcutaneous adipose tissue infections, infected wounds, abscesses, specific infectious processes in soft tissues and skin caused by pathogens sensitive to Dalacin (erysipelas and panaritium (paronychia));
• Lower respiratory tract infections, including pneumonia, bronchitis, lung abscess, and pleural empyema;
• Gynecological infectious diseases, including endometritis, infections of the tissues surrounding the vagina (abscesses of the fallopian ovaries and tubes, subcutaneous fatty tissue), inflammatory diseases of the pelvic organs and salpingitis (simultaneously with antibacterial drugs active against gram-negative aerobic pathogens, for example);
• Infectious diseases of the joints and bones, including septic arthritis and osteomyelitis;
• Infectious diseases of the abdominal cavity, including abdominal abscesses and peritonitis (simultaneously with other antibacterial drugs that act on gram-negative aerobic bacteria);
• Infectious diseases of the cervix caused by Chlamydia trachomatis (as monotherapy);
• Oral infections (periodontitis and periodontal abscess);
• Endocarditis and septicemia;
• Malaria, incl. caused by multiresistant Plasmodium falciparum (as monotherapy or simultaneously with chloroquine or quinine);
• Toxoplasmosis encephalitis in AIDS patients (simultaneously with pyrimethamine in case of intolerance to standard therapy);
• Pneumocystis pneumonia in AIDS patients (simultaneously with primaquine in case of intolerance to standard therapy).

Vaginal cream is used in the following cases:

• Inflammatory processes in the vagina due to exposure to pathogenic microflora;
• Gardrenellosis;
• Dysbacteriosis of the vagina;
• Colpitis, vaginitis;
• As part of complex therapy for diseases of the pelvic organs in women - adnexitis, endocervicitis, endometritis and others.

Gel Dalacin is used in the treatment of acne, folliculitis, staphyloderma.

Instructions for use Dalacin, dosage

Capsules are used orally, without chewing, simultaneously with meals, drinking plenty of water.

Standard dosages of Dalacin capsules, according to the instructions for use:

• Adults - 150 mg \ 4 times a day, in severe cases 300-450 mg \ 4 times a day, with chlamydial infections, 450 mg.
• Children 8-25 mg/kg body weight per day, divided into 4 divided doses.

In the treatment of infections caused by beta-hemolytic streptococcus, Dalacin is used in the doses described above. The duration of the therapeutic course is at least 10 days.

Treatment of pelvic inflammatory disease begins with intravenous clindamycin 900 mg every 8 hours, concomitantly with a suitable antibacterial agent for at least 4 days.

After the condition improves, therapy is continued for at least 2 more days, after which Dalacin is prescribed in the form of capsules in a single dose of 450-600 mg. The drug is taken daily every 6 hours. The full course of treatment is 10-14 days.

For the prevention of endocarditis in patients with hypersensitivity to penicillins, Dalacin is prescribed in dosages: for adults - 600 mg; children - 20 mg / kg. The instruction recommends taking the drug 1 hour before a minor dental or surgical intervention, or any other procedure in which there is a risk of developing endocarditis.

Vaginal cream Dalacin

Adult patients (over 18 years old) - 1 full applicator of the cream is injected into the vagina 1 time per day in the evening before bedtime. The duration of the course of drug therapy is from 3 to 7 days.

If there is no improvement or the condition worsens, you should immediately consult a doctor.

The applicator is intended for single use. After introducing a dose of cream into the vagina, the applicator should be discarded.

Instructions for Dalacin candles

Suppositories can be administered without an applicator and with an applicator. After each use, the applicator should be washed with warm soapy water and dried well.

The introduction of suppositories using the applicator:

• The plastic applicator, which is in the package with the drug, is designed to facilitate the introduction of the suppository into the vagina.
• It is necessary to remove the suppository from the foil.
• Place the flat end of the suppository into the applicator opening.
• While lying on your back, pull your knees up to your chest.
• Holding the applicator horizontally by the ribbed end of the body, gently insert it into the vagina as deeply as possible.
• Slowly pressing the piston, insert the suppository into the vagina.
• Carefully remove the applicator.

Side effects

The instruction warns of the possibility of developing the following side effects when prescribing Dalacin suppositories:

• From the reproductive system: irritation of the mucous membrane of the vulva and vagina, pain in the vagina, vaginal candidiasis, menstrual disorders, vaginal discharge, vaginal infections.
• From the urinary system: dysuria, pyelonephritis.
• From the digestive system: diarrhea, nausea, vomiting.
• On the part of the skin: itching, rash.
• On the part of the body as a whole: fungal infections, abdominal cramps, headache, localized abdominal pain, fever, pain in the side, generalized pain.
• Local reactions: pain, itching, local swelling at the injection site.

Gel: dryness and irritation of the skin, contact dermatitis, folliculitis, increased production of sebum. Systemic effects are rarely manifested - nausea, vomiting, diarrhea, colitis may develop.

Cream: itching and swelling at the injection site, irritation of the mucous membrane, pain in the vagina, vaginal candidiasis, trichomonas vaginitis, cycle disorders, bleeding. Systemic side effects can be manifested by headache, dizziness, dysuria, pain in the lower abdomen, bloating, diarrhea or constipation, nausea, fungal and bacterial infections, allergic reactions (rash, itching, urticaria).

Contraindications

Dalacin is contraindicated in the following cases:

• history of antibiotic-associated colitis;
• age up to 18 years (data on safety and efficacy are not available);
• hypersensitivity to clindamycin, lincomycin or any component of the drug.

It is necessary to avoid getting the gel for external use on the mucous membranes of the mouth and eyes. After applying the drug, wash your hands thoroughly. In case of accidental contact with sensitive surfaces (skin abrasions, eyes, mucous membranes), rinse them with plenty of cool water.

Overdose

When anaphylactic reactions appear, glucocorticosteroids, antihistamines are administered. There is no antidote. Hemodialysis is ineffective.

With an overdose of suppositories or vaginal cream - diarrhea, including hemorrhagic, pseudomembranous colitis. Carry out symptomatic therapy.

Dalacin analogues, price in pharmacies

If necessary, you can replace Dalacin with an analogue of the active substance - these are drugs:

1. Gel Klindivit,
2. Gel Clindatop,
3. Candles Clindacin,
4. Cream vaginal,
5. Clindes,
6. Clindamycin capsules.

When choosing analogues, it is important to understand that the instructions for use of Dalacin, price and reviews, do not apply to drugs of similar action. It is important to consult a doctor and not to make an independent replacement of the drug.

Price in Russian pharmacies: Dalacin 2% vaginal cream 20g + 3 applicators - from 565 rubles, 100mg 3 vaginal suppositories. - from 641 rubles, the price of 1% Dalacin gel 30g - from 750 rubles.

Keep out of the reach of children at temperatures up to 25 °C. Do not freeze. Shelf life of the capsule is 5 years, vaginal cream, gel for external use - 2 years, vaginal suppositories - 3 years.

Conditions for dispensing from pharmacies - by prescription.

Dalacin(Dalacin) is a lincosamide antibiotic. Active ingredient of the drug: Clindamycin. Dalacin is actively prescribed in gynecology for the treatment of bacterial vaginosis. It has convenient release forms: vaginal suppositories, vaginal cream, gel for external use, solution for intravenous and intramuscular administration. Most forms of the antibiotic clindamycin are prescribed by a doctor.

Dalatsin candles. Photo: pininfo.ru
Dalacin vaginal cream. Photo: jdhsalumni.info
Dalacin cream. Photo: yapteka.ru
Dalacin gel. Photo: smed.ru
Dalacin Ts. Photo: nebolet.com

Instructions for use Dalacin

Active substance	Clindamycin (Clindamycin)
pharmachologic effect	Antibacterial; Antiprotozoal
Holiday conditions	Prescription (OTC - Dalacin gel for topical use 1%)
Release form	Suppositories vaginal; Cream vaginal; Gel for external use; Solution for intravenous and intramuscular administration
Pregnancy and lactation	Contraindicated
Age group	1 month +
Best before date	2 years
Storage conditions	Not higher than +25°С
Analogues	; ; Clindagel; Clindatop; ; Clindes; Klindovit
Category	Antibacterial drugs
Manufacturer	Pfizer (USA)
Price	724 - 1170 rubles.

Application of Dalacin

Instructions for use of candles Dalacin

Introduction of Dalacin suppositories without applicator:

• Gently insert the suppository into the vagina with the middle finger as far as possible.

The introduction of Dalacin suppositories using an applicator:

• The plastic applicator, which is in the package with the drug, is designed to facilitate the introduction of the suppository into the vagina.
• It is necessary to remove the suppository from the foil.
• Place the flat end of the suppository into the applicator opening.
• While lying on your back, pull your knees up to your chest.
• Holding the applicator horizontally by the ribbed end of the body, gently insert it into the vagina as deeply as possible.
• Slowly pressing the piston, insert the suppository into the vagina.
• Carefully remove the applicator from the vagina.
• After each use, the applicator should be washed with warm soapy water and allowed to dry completely.

Instructions for use Dalacin cream

1 full applicator (5 g of cream, approximately 100 mg of clindamycin) is inserted into the vagina, preferably at bedtime, for 3 or 7 consecutive days.

Rules for the use of the drug:

In a package with 20 g of Dalacin cream there are 3 plastic applicators, and in a package with 40 g there are 7 applicators designed for the correct introduction of the cream into the vagina.

• Remove the cap from the cream tube. Screw the plastic applicator onto the threaded neck of the tube.
• Rolling the tube from the opposite end, gently squeeze the cream into the applicator. The applicator is full when its plunger reaches the stop.
• Unscrew the applicator from the tube and screw on the cap.
• While lying on your back, pull your knees up to your chest.
• Holding the applicator horizontally, gently insert it into the vagina as deeply as possible without causing discomfort.
• Slowly pressing the piston until it stops, insert the cream into the vagina.
• Carefully remove the applicator from the vagina and discard it.

Application instruction of Dalacin gel

Outwardly. A thin layer of Dalacin gel is applied to the affected area of ​​clean, dry skin (on the face is possible) 2 times / day. To obtain satisfactory results, treatment should be continued for 6-8 weeks, and if necessary, you can continue up to 6 months. If after using the drug for several months the effectiveness of therapy decreases, you should take a break in treatment for 4 weeks.

Instructions for use Dalacin C

With the / m or / in the introduction of adults - 0.6-2.7 g / day in divided doses. In very severe infections, IV can be administered up to 4.8 g / day. Maximum doses: with intramuscular administration, a single dose is 600 mg, with intravenous infusion lasting 1 hour - 1.2 g. With intramuscular or intravenous administration to children over the age of 1 month - 15-40 mg / kg /day in divided doses. In severe infections, a total dose of at least 300 mg/day should be administered.

The drug Dalacin is an effective remedy against. Apply the drug in the form of a gel for external use. A thin layer of Dalacin is applied to the affected area of ​​clean, dry skin 2 times / day. Often consumers of Dalacin gel mistakenly call it Dalacin ointment. In some countries, Dalacin gel was called Dalacin T.

Dalacin for acne. Photo: yandex.ru

Dalacin for men

Doctors prescribe the drug Dalacin not only to women, but also to men in the treatment of thrush. To do this, use the form in the form of a vaginal cream 2%. Apply a thin layer on a clean, dry, affected area 2 times a day.

Dalacin with gardnerellosis

Gardnerella bacteria can cause such an unpleasant disease as bacterial vaginosis (or dysbiotic changes in the vaginal microflora). With this disease, treatment with Dalacin is prescribed after the results of the tests.

Dalacin with ureaplasma

The drug Dalacin is prescribed for the treatment of uraplasmosis in women. It is necessary to inject into the vagina with a dispenser of 5 mg in the evening before bedtime for 7 days.

Composition of Dalacin

Candles Dalacin

• active substance: Clindamycin (in the form of phosphate) 100 mg;
• excipients: solid fat (Witepsol H-32, a mixture of triglycerides, diglycerides and monoglycerides) - about 2.4 g.

Vaginal cream Dalacin

• active substance: Clindamycin (in the form of phosphate) 20 mg;
• excipients: sorbitan monostearate - 20 mg, polysorbate 60 - 50 mg, propylene glycol - 50 mg, stearic acid - 21.4 mg, cetostearyl alcohol - 32.1 mg, cetyl palmitate - 32.1 mg, mineral oil - 64.2 mg , benzyl alcohol - 10 mg, purified water - q.s.

Structural formula of Clindamycin C 18 H 33 ClN 2 O 5 S. Photo: wikipedia.org

Gel Dalacin

• active substance: Clindamycin (in the form of phosphate) 10 mg;
• excipients: allantoin - 2 mg, methylparaben - 3 mg, propylene glycol - 50 mg, polyethylene glycol - 100 mg, carbomer 934P - 7.5 mg, sodium hydroxide solution 40% - q.s., purified water - q.s. up to 1 year

Active ingredient: Clindamycin (in the form of phosphate) 150 mg per 1 ml.

Indications for use Dalacin

Severe infectious and inflammatory diseases caused by microorganisms sensitive to clindamycin:

• pneumonia;
• lung abscess;
• pleural empyema;
• osteomyelitis;
• endometritis;
• adnexitis;
• purulent infections of the skin, soft tissues, wounds, peritonitis;
• also used as a prophylaxis of peritonitis and intra-abdominal abscesses after perforation or intestinal injury (in combination with aminoglycosides);
• as a reserve antibiotic for infections caused by strains of staphylococcus and other gram-positive microorganisms resistant to penicillin;
• as a means of prevention during tooth extraction;
• acne vulgaris (for external use);
• vaginosis caused by sensitive microorganisms (for local use in gynecology).

Contraindications

• Hypersensitivity to clindamycin or lincomycin.
• For systemic use: severe violations of the liver or kidneys, myasthenia gravis, bronchial asthma, ulcerative colitis (history), pregnancy, lactation, children under 1 month old, old age.

For cream Dalacin vaginal 2% and vaginal suppositories:

• age up to 18 years (data on safety, efficacy are not available);
• hypersensitivity to clindamycin, lincomycin or any component of the drug.

• history of antibiotic-associated colitis;
• age up to 12 years (data on safety and efficacy are not available);
• hypersensitivity to clindamycin or lincomycin in history.

Side effects of Dalacin

• From the urinary system:, irritation of the mucous membrane of the vulva and vagina, vulvovaginitis, trichomonas vaginitis, vaginal infections, menstrual disorders, vaginal pain, uterine bleeding, dysuria, vaginal discharge, urinary tract infections, abnormal delivery, endometriosis, glucosuria, proteinuria.
• General: fungal infections, generalized abdominal pain, localized, bacterial infections, abdominal cramps, headache, lower abdominal pain, bad breath, inflammatory edema, upper respiratory tract infections, generalized pain, back pain, abdominal distention, abnormal microbiological results analyzes from the norm, .
• From the digestive system: diarrhea, vomiting, constipation, dyspepsia, flatulence, gastrointestinal disorders.
• From the side of the skin: pruritus, rash, maculopapular rash, erythema, itching at the injection site, candidiasis (skin), urticaria.
• From the side of the central nervous system: dizziness.
• From the endocrine system: hyperthyroidism.
• From the respiratory system: nose bleed.

For gel Dalacin for external use 1%:

After a course of treatment with Dalacin, in some cases, small bleeding was observed. You need to see a doctor right away! Maybe it's erosion.

Itching after Dalacin

Itching, rashes, burning, swelling (side effects) on the skin may occur after treatment with Dalacin (vaginal suppositories or vaginal cream), if there is an overdose of the drug or non-compliance with the correct application regimen.

pharmachologic effect

Vaginal suppositories and vaginal cream 2%:

Antibiotic Dalacin of the lincosamide group for topical use. Clindamycin phosphate is not active in vitro, but is rapidly hydrolyzed in vivo to form clindamycin, which has antibacterial activity. Clindamycin inhibits protein synthesis in microbial cells by interacting with the 50S subunit of ribosomes. Under in vitro conditions, the following microorganisms that cause bacterial vaginosis are sensitive to clindamycin: Gardnerella vaginalis, Mobiluncus spp., Mycoplasma hominis, Bacteroides spp., Peptostreptococcus spp.

Gel Dalacin for external use 1%:

Clindamycin phosphate is not active in vitro, but after application to the skin, it is rapidly hydrolyzed by phosphatases in the ducts of the sebaceous glands to form clindamycin, which has antibacterial activity. The sensitivity of all studied strains of Propionibacterium acnes to clindamycin in vitro (MIC 0.4 µg/ml) was shown. After application of clindamycin to the skin, the amount of free fatty acids on the surface of the skin decreases from about 14% to 2%.

Solution for intravenous and intramuscular administration:

Antibiotic Dalacin of the lincosamide group. In therapeutic doses it has a bacteriostatic effect, in high doses it has a bactericidal effect on sensitive strains. Violates intracellular protein synthesis in the early stages by binding to the 50S subunit of bacterial ribosomes. Clindamycin is active against most aerobic Gram-positive bacteria, including Staphylococcus spp. (including strains producing penicillinase); Streptococcus spp., Bacillus anthracis, Corynebacterium diphtheriae.

Clindamycin is also active against anaerobic Gram-positive bacteria including Eubacterium, Propionibacterium, Peptococcus, Peptostreptococcus spp., many strains of Clostrtidium perfringens and Clostrtidium tetani. Among Gram-negative anaerobes, Fusobacterium spp. are sensitive to clindamycin. (excluding F. varium which is usually resistant), Veillonella, Bacteroides spp. (including B. fragilis).

With respect to Mycoplasma spp. clindamycin is usually less active than erythromycin. Some strains of Actinomyces spp. are sensitive to clindamycin. and Nocardia asteroides. Some antiprotozoal activity has been reported against Toxoplasma gondii and Plasmodium spp. Enterococcus spp., methicillin-resistant strains of Staphylococcus aureus, most gram-negative aerobic bacteria (including Enterobacteriaceae spp.), Neisseria gonorrhoeae, Neisseria meningitidis and Haemophilus influenzae, as well as fungi (including yeast) and viruses are resistant to clindamycin.

Precautionary measures

Dalacin during pregnancy:

Clindamycin crosses the placental barrier into the circulatory system of the fetus. It is allocated with breast milk. Clindamycin for oral and parenteral administration is contraindicated for use during pregnancy and lactation.

Dalacin vaginal suppositories and vaginal cream 2%:

When using clindamycin intravaginally in the II or III trimester of pregnancy, there was no increase in the incidence of congenital anomalies of the fetus. If Dalacin vaginal suppositories are used during the II or III trimesters of pregnancy (although there have been no official studies on the use of suppositories in pregnant women), then an adverse effect on the fetus is unlikely. The use of the drug in the II-III trimester of pregnancy is possible if the potential benefit to the mother outweighs the risk to the fetus.

Adequate controlled studies on the use of the drug in the first trimester of pregnancy have not been conducted, therefore, Dalacin vaginal suppositories can be prescribed to women in the first trimester of pregnancy only according to absolute indications, i.e. when the potential benefit of drug therapy outweighs the potential risk to the fetus.

In animal studies, with the introduction of clindamycin s / c or inside, no negative effects on the fetus were found, with the exception of cases of taking the drug at doses that are toxic to the mother.

It is not known whether clindamycin is excreted in breast milk after intravaginal use. Clindamycin is found in breast milk after oral or parenteral administration, therefore, during breastfeeding, either the use of the drug should be discontinued or breastfeeding should be discontinued, given the importance of the use of the drug for the mother.

Application for violations of liver function:

In severe violations of liver function, systemic use is contraindicated.

Application for violations of kidney function:

In severe renal impairment, systemic use is contraindicated.

Application in children:

In children under 1 month of age, the systemic use of the Dalacin antibiotic is contraindicated.

The use of the drug under the age of 18 years is contraindicated (data on safety and efficacy are not available).

For topical gel 1%:

The use of the drug Dalacin in children under the age of 12 years is contraindicated (data on safety and efficacy are not available).

Use in elderly patients:

In the elderly, the systemic use of the antibiotic Dalacin is contraindicated.

For suppositories and vaginal cream 2%:

Clinical studies of clindamycin vaginal suppositories did not include enough patients aged 65 years or older to assess the difference in clinical response to therapy between this age group and younger patients.

Special instructions:

Carefully use the antibiotic Dalacin in patients with a history of gastrointestinal diseases.

• If diarrhea or symptoms of colitis occur, clindamycin should be discontinued.
• Pseudomembranous colitis can occur both while taking clindamycin and 2-3 weeks after stopping treatment. Do not use drugs that inhibit intestinal motility.
• It is not recommended to use clindamycin concomitantly with drugs that slow down the neuromuscular transmission.

For vaginal suppositories and vaginal cream 2%:

• It is not recommended to use Dalacin antibiotic intravaginally simultaneously with other intravaginal agents. Before prescribing the drug, using appropriate laboratory methods, vulvovaginitis caused by Trichomonas vaginalis, Chlamydia trachomatis, Neisseria gonorrhoeae, Candida albicans and the Herpes simplex virus should be excluded.
• Intravaginal use of clindamycin may lead to overgrowth of non-susceptible organisms, especially yeast-like fungi.
• The use of clindamycin (like almost all antibiotics) orally or parenterally is associated with the development of severe diarrhea and, in some cases, pseudomembranous colitis. With the development of severe or prolonged diarrhea, the drug should be discontinued and, if necessary, appropriate diagnostic and therapeutic measures should be taken.
• Patients should be warned that during drug therapy, sexual intercourse should be avoided, as well as the use of other means for intravaginal administration (tampons, douching).
• The preparation contains components that can reduce the strength of latex or rubber products (condoms, contraceptive vaginal diaphragms). Therefore, the use of such products during treatment with Dalacin and within 72 hours after use is not recommended.
• It is not recommended to use the drug Dalacin vaginal suppositories during menstruation. It is necessary to postpone the start of therapy until the end of menstruation.
• The drug does not affect the ability to drive vehicles and engage in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

For topical gel 1%:

• Avoid getting the drug Dalacin on the mucous membrane of the eyes and mouth.
• Wash your hands thoroughly after applying the gel. In case of accidental contact with sensitive surfaces (eyes, skin abrasions, mucous membranes), rinse the area with plenty of cool water.
• With external use of clindamycin, cases of diarrhea and colitis are rare, however, caution should be exercised, and if severe or prolonged diarrhea develops, the drug should be discontinued and, if necessary, appropriate diagnostic and therapeutic measures should be taken. Usually, the onset of diarrhea, colitis, and pseudomembranous colitis is noted within a few weeks after completion of oral and parenteral clindamycin therapy. In the case of severe diarrhea, the question of the advisability of performing a colonoscopy should be considered. The administration of drugs that reduce GI motility, such as opioid analgesics and diphenoxylate with atropine, may prolong and/or worsen the course of this complication. Vancomycin has been found to be effective against antibiotic-associated pseudomembranous colitis caused by Clostridium difficile. The usual dose, divided into 3-4 doses for adults, is 500 mg to 2 g of vancomycin/day orally for 7-10 days.
• There is no reason to believe that the use of the drug Dalacin can affect the ability to drive a car and control mechanisms.

Dalatsin's analogs

• (a cheaper analogue of Dalacin vaginal cream)
• Clindagel
• Klindatop
• Clindes
• Klindovit

Dalacin tablets

In the form of tablets, Dalacin is not released, only in the form of capsules. In the Russian Federation, this form is not registered. In countries where this drug is registered, it is produced in a dose of 150 mg and 300 mg. It is indicated for infectious and inflammatory diseases caused by anaerobic bacteria sensitive to clindamycin or strains of gram-positive aerobic bacteria, such as Streptococcus spp., Staphylococcus spp. and Pneumococcus spp., as well as Chlamydia trachomatis serovars sensitive to clindamycin:

• upper respiratory tract infections, incl. tonsillitis, pharyngitis, sinusitis;
• inflammation of the middle ear, scarlet fever;
• infections of the lower respiratory tract, incl. bronchitis, pneumonia, pleural empyema and lung abscess;
• infectious diseases of the skin and soft tissues, incl. , infection of the subcutaneous adipose tissue, impetigo, abscesses, infected wounds, specific infectious processes in the skin and soft tissues caused by pathogens sensitive to this drug, such as erysipelas and paronychia (panaritium);
• infectious diseases of bones and joints, incl. osteomyelitis and septic arthritis;
• gynecological infections, including endometritis, subcutaneous fat infections, infections of the tissues surrounding the vagina, abscesses of the fallopian tubes and ovaries, salpingitis and pelvic inflammatory disease, in combination with an antibacterial drug active against gram-negative aerobic pathogens (for example, gentamicin);
• monotherapy of infectious diseases of the cervix caused by Chlamydia trachomatis;
• infectious diseases of the abdominal cavity, including: peritonitis and abdominal abscesses (in combination with other antibacterial drugs that act on gram-negative aerobic bacteria);
• septicemia and endocarditis;
• oral infections such as: periodontal abscess and periodontitis;
• toxoplasmic encephalitis in AIDS patients (in combination with pyrimethamine in patients with intolerance to standard therapy);
• pneumocystis pneumonia in patients with AIDS (in combination with primaquine in patients with intolerance or resistant to standard therapy);
• malaria, incl. caused by multiresistant Plasmodium falciparum, either as monotherapy or in combination with quinine or chloroquine;
• prevention of endocarditis in patients with hypersensitivity to penicillins.

Take the antibiotic Dalacin as directed by your doctor!

Adults: 600-1800 mg/day orally in 2, 3 or 4 divided doses (equal doses).

Children: 8-25 mg/kg body weight/day orally in 3-4 divided doses (equal doses).

To avoid irritation of the esophageal mucosa, the capsules should be taken with a full glass of water. If the calculated dose per dose is lower than the content of clindamycin in the capsule or there are swallowing disorders, it should be recommended to use parenteral forms of the drug.

Infections caused by beta-hemolytic streptococcus:

Doses of Dalacin are indicated above, treatment should be continued for at least 10 days.

Infectious and inflammatory diseases of the pelvic organs:

900 mg clindamycin IV every 8 hours + IV suitable antibacterial active against Gram-negative aerobic pathogens (eg, gentamicin 2.0 mg/kg followed by 1.5 mg/kg every 8 hours for patients with normal kidney function), for at least 4 days, and after the onset of improvement in the patient's condition - for at least 48 hours. Then they switch to taking clindamycin orally at 450-600 mg every 6 hours daily. The full course of therapy is 10-14 days.

Cervical infections caused by Chlamydia trachomatis:

450-600 mg orally 4 times a day daily for 10-14 days.

Toxoplasmosis encephalitis in AIDS patients:

In patients who cannot tolerate standard therapy, clindamycin is used in combination with pyrimethamine as follows: 600-1200 mg orally every 6 hours for 2 weeks, then 300-600 mg orally every 6 hours. Pyrimethamine is prescribed at a dose of 25-75 mg orally every day . Usually the course of therapy is 8-10 weeks. When using higher doses of pyrimethamine, folinic acid should be prescribed at a dose of 10-20 mg / day.

Pneumocystis pneumonia in AIDS patients:

300-450 mg orally every 6 hours for 21 days and primaquine 15-30 mg orally once a day for 21 days.

Acute streptococcal tonsillitis/pharyngitis:

Dalacin 300 mg orally 2 times a day for 10 days.

Malaria:

10–20 mg/kg/day by mouth for adults and 10 mg/kg/day for children every 12 hours in equal doses for 7 days as monotherapy, or in combination with quinine (12 mg/kg every 12 hours) or chloroquine ( 15-25 mg every 24 hours) for 3-5 days.

Prevention of endocarditis in patients with hypersensitivity to penicillins:

600 mg orally for adults and 20 mg/kg for children 1 hour before minor surgery or dental intervention or any other procedure associated with a risk of endocarditis.

Elderly patients:

There is no need to modify the dose of Dalacin antibiotic in normal (for a given age) liver and kidney function.

Patients with impaired renal and hepatic function:

There is no need to modify the dose of Dalacin.

Dalatsin Ts. Photo: yandex.ru

Both drugs are analogues of each other. The composition contains the active substance: Clindamycin. Dalacin is produced in the form of vaginal suppositories, vaginal cream 2%, gel for external use 1% and solution for intravenous and intramuscular administration. Release form: vaginal cream 2%, solution for intravenous and intramuscular administration, capsules. According to the indications, both drugs are the same, except that Dalacin has a gel form for external use, which is prescribed for the treatment of acne. Dalacin is the original drug. Medicines are prescribed by a doctor!

The country of origin of Dalacin is the USA. Clindamycin is produced by Russia and Serbia. At a cost, Dalacin is more expensive than Clindamycin.

Dalacin or Clindamycin. Photo: lososeans.info

The drugs are lincosamide antibiotics. The active ingredient in Dalacin and Clindamycin is Clindamycin. Dalacin is produced in the form of vaginal suppositories, vaginal cream 2%, gel for external use 1% and solution for intravenous and intramuscular administration. in turn, they are produced only in the form of vaginal suppositories and vaginal cream (there is a one-component and Clindamycin B prolong - a two-component drug). Clindamycin suppositories can be purchased at a pharmacy without a doctor's prescription!

Dalacin releases USA. Clindamycin is produced in Russia. At a cost, Clindacin is cheaper than Dalacin.

Dalacin or Clindamin. Photo: yandex.ru

The drugs are analogues of each other. The active ingredient is clindamycin. Dalacin release form: vaginal suppositories, vaginal cream 2%, gel for external use 1% and solution for intravenous and intramuscular administration. Klindovit is produced in the form of a gel for external use. used to treat acne. The choice of this or that drug remains with the doctor!

Klindovit is produced by Russia. Dalacin is made in the USA. The cost is cheaper than Klindovit than Dalacin.

Dalacin or Klindovit. Photo: lososeans.info

Dalacin or Metronidazole

The drugs are not analogues of each other. Dalacin is an antibiotic-lincosamide (active ingredient: Clindamycin). is an antiprotozoal drug with the active ingredient - Metronidazole. The drug is prescribed for the following diseases:

• urogenital trichomoniasis (including vaginitis);
• nonspecific vaginitis of various etiologies (confirmed by clinical and microbiological data).

For bacterial vaginosis, doctors prescribe a more effective treatment regimen - a combination of Metronidazole and Dalacin. At a cost, Dalacin is more expensive than Metronidazole.

• Capsules.
• Solution for injection Dalacin C Phosphate.
• Suppositories are vaginal.
• Cream vaginal 2%.
• Gel 1%.

pharmachologic effect

Antibacterial, anti-inflammatory.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Active substance clindamycin is an antibiotic of the group lincosamides . Depending on the dose, it has a bactericidal and bacteriostatic effect, disrupting protein metabolism in the ribosome membrane of pathogenic microorganisms.

sensitive to him gram-positive aerobic and anaerobic bacteria , actinomycetes , mycoplasmas , bacteroids . Shows effectiveness in gynecological infections that cause Mycoplasmahominis , Mobiluncusspp ., Gardnerellavaginalis .

drug resistant Trichomonas vaginalis and candida albicans .

All strains Propioni bacterium acne sensitive to clindamycin, which explains its effectiveness in acne vulgaris .

Pharmacokinetics

At ingestion there is a high (up to 90%) absorption, which is not affected by food intake. The maximum concentration in the blood is determined after 50-60 minutes. It penetrates well into liquids and organs, high concentrations are observed in bone tissue. It is metabolized in the liver and excreted in the urine, in small amounts with feces. T 1 / 2 2-4 hours, with impaired renal function and in the elderly increases to 5 hours. No cumulation is observed with prolonged use.

With the introduction candles within 3 days, 30% of the dose is absorbed into the bloodstream. Cmax in the blood is reached after 1-10 hours, an average of 5 hours.

When applied cream within a week, Cmax in the blood is determined after 4-24 hours. Systemic absorption is 5% of the administered dose. Systemic exposure with this route of administration is less pronounced than with oral or intravenous administration. T 1/2 is 1.5-2.6 hours.

After applying to the skin gel the active substance is hydrolyzed in the ducts of the sebaceous glands and is formed clindamycin which exhibits antibacterial activity. After external application in the content comedones a sufficient concentration of the active substance is created, and insignificant concentrations are determined in the blood and urine.

Indications for use

Candles Dalacin and vaginal cream: bacterial vaginitis .

Gel Dalacin T: treatment , folliculitis , staphyloderma .

Capsules Dalacin C and solution:

• otitis media , , pneumonia , lung abscess , complicated ;
• furunculosis , acne, abscesses, erysipelas , , infected wounds, purulent ;
• , , salpingitis ;
• abdominal abscesses, septicemia, peritonitis ;
• and periodontal abscess ;
• prevention endocarditis , infections during surgical interventions.

Contraindications

Taking the drug orally and parenterally is contraindicated in:

• antibiotic-associated ;
• hypersensitivity to lincosamide ;
• under the age of 1 month;
• severe violations of the liver and kidneys;
• pregnancy and lactation.

A contraindication for the use of cream and suppositories is the first trimester of pregnancy and lactation, for the use of the gel - age up to 12 years.

Side effects

Gel: dryness and irritation of the skin, , folliculitis , increased production of sebum. Rarely, systemic effects occur - nausea, vomiting, diarrhea, possible development colitis .

Cream: itching and swelling at the injection site, irritation of the mucous membrane, pain in the vagina, , trichomonas vaginitis , cycle disorders, bleeding. Systemic side effects may include headache, dizziness, dysuria , lower abdominal pain, bloating, or , nausea, fungal and bacterial infections allergic reactions (rash, itching, ).

Capsules and solution for injection:

• stomach pain, nausea, loose stools, esophagitis , ;
• eosinophilia , leukopenia , agranulocytosis , thrombocytopenia ;
• hives, rash, itching, epidermal necrolysis ;
• (with rapid administration) and anaphylactoid reactions;
• with rapid intravenous administration of the drug - weakness, dizziness, hypertension;
• with intramuscular - redness and abscesses at the injection site.

Instructions for Dalacin (Method and dosage)

Dalacin C capsules are used orally, without chewing, at the same time as eating, drinking plenty of water. Adults - 150 mg 4 times a day, in severe cases 300-450 mg 4 times a day, with chlamydial infections 450 mg. Children 8-25 mg/kg body weight per day, divided into 4 divided doses. Duration of reception is established by the doctor.

Cream Dalacin, instructions for use

A full applicator with cream (5 g) is inserted into the vagina at night, the procedure is carried out according to the doctor's prescription from 3 to 7 days. The plastic applicator is screwed onto the cream tube and the cream is squeezed into it. After that, unscrew the applicator and, holding it horizontally, insert it deeply into the vagina, while lying on your back with your knees pulled up to your chest. By pressing the plunger of the applicator, inject the cream. The applicator is intended for single use.

In the first trimester of pregnancy, intravaginal use of the cream is possible according to absolute indications. Application in the II and III trimesters does not entail congenital anomalies.

Candles Dalacin, instructions for use

Candles are administered intravaginally at bedtime, one at a time for 3 days in a row. They can be administered without an applicator: in the supine position with knees pulled up with the middle finger of the hand, the candle is inserted as deep as possible.

The plastic applicator facilitates the introduction of the suppository. The flat end of the suppository is placed in the applicator opening. Holding the applicator horizontally, insert it deep into the vagina. By pressing the piston, the suppository is injected. The applicator can be used several times by washing it with warm water and soap.

The gel is applied in a thin layer only on the affected parts of the skin 2 times a day. Treatment continues for 6-8 weeks, sometimes up to 6 months. After use for several months, the effectiveness of the drug may decrease, in such cases a break is taken for a month.

What is the difference between Dalacin and Dalacin T?

As seen, clindamycin It has several dosage forms with different indications and methods of application. Only vaginal cream and suppositories have the name "Dalacin". In all forms, the active substance is presented in different concentrations.

For treatment vaginitis Dalacin 2% vaginal cream is applied. Candles contain 100 mg of clindamycin, and for treatment acne a gel with 1% clindamycin is produced, which has the trade name Dalacin T. Sometimes the gel and cream are combined under the common name "ointment", which is not very correct.

What is the difference between Dalacin and Dalacin C?

There is another form of release - clindamycin capsules, which are called Dalacin C. Dalacin C capsules are used orally, and Dalacin C Phosphate solution is intended for intravenous and intramuscular injections. These dosage forms have other indications for use.

Overdose

Cases of overdose when ingesting the recommended doses are not observed. When anaphylactic reactions occur, glucocorticosteroids , antihistamines . There is no antidote. Hemodialysis is ineffective.

There are also no reports of overdose of intravaginal cream and suppositories. Possible manifestation of systemic reactions: diarrhea , including hemorrhagic , pseudomembranous colitis . Carry out symptomatic therapy.

Interaction

Enhances action muscle relaxants , since it disrupts neuromuscular transmission, there is a cross-reaction with lincomycin .

Inhibits activity aminoglycosides , macrolides and chloramphenicol . The drug in capsules is not prescribed in conjunction with , , , barbiturates , , .

When assigned with opioids the depressant effect on respiration increases.

The components of the cream reduce the strength of condoms, so they are not recommended for use when using a vaginal cream.

Terms of sale

On prescription.

Storage conditions

At a temperature not exceeding 25 C.

Best before date

Gel, cream, injection solution: 2 years.

Candles: 3 years.

Capsules: 5 years.

Analogues

Coincidence in the ATX code of the 4th level:

Gel Clindivite and Klindatop , candles , cream , Clindes , ,capsules .

Reviews about Dalacin

Quite often there are reviews about Gel Dalacin T and I must say that they are polar. Some praise this acne gel and note its effectiveness, it does not dry the skin, eliminates oily sheen, removes acne and characterizes it as an excellent remedy.

“He became a salvation”, “dalacin does not help right away.” But many users say that it has a weak effect and a high cost compared to peers.

Many women had to deal with the treatment of vaginitis with vaginal cream and Dalacin suppositories. Reviews about candlelight Dalacin mostly positive. Women note a good therapeutic effect and ease of use (using the applicator). However, everyone notes a slight burning sensation in the vagina after the introduction of a candle.

Reviews on Dalacin cream there are more negative ones. First of all, there is a lack of a pronounced effect, the presence of a strong burning sensation when the cream is injected, and a high cost. “I was treated for a week - there was no result”, “... Dalacin cream did not help me - at first there was an improvement, but after 3 days everything fell into place again”, “caused severe irritation and pain.” Many women prefer vaginal gel .

Dalacin price, where to buy

You can buy drugs in pharmacies in cities in Russia and other countries. The price of Dalacin cream 20 g is 529-614 rubles. The price of Dalacin candles ranges from 552-653 rubles, and the price of Dalacin T gel is 675-826 rubles. Tablets (capsules) are currently not available in Russian pharmacies.

Buying gel in Minsk is also problematic.

• Internet pharmacies in Russia Russia
• Internet pharmacies in Ukraine Ukraine
• Internet pharmacies in Kazakhstan Kazakhstan

LuxPharma * special offer

Dalacin C phosphate solution d / in / in and / m injections 300 mg / 2 ml amp. 1 PC

ZdravCity

Dalacin gel 1% 30g Pharmacia & Upjohn

Dalacin cream vag. 2% 40g (+7applic) Pharmacia & Upjohn Company

Dalacin supp. vag. 100mg n3 Pharmacia & Upjohn

Dalacin cream vag. 2% 20g (+3 applications) Pharmacia & Upjohn