Chondroxide purpose. A product for active nutrition and restoration of cartilage condition - Chondroxide tablets: instructions for use, results in the treatment of osteoarthritis and osteochondrosis. Composition and release form

Chondroxide is a drug that improves the regeneration of cartilage tissue. The ointment and gel additionally have an anti-inflammatory effect.

The active substance, sodium chondroitin sulfate, takes part in the phosphorus-calcium metabolism process that occurs in cartilage tissue. Chondroitin sulfate is essential for the normal functioning of joints and intra-articular cartilage.

Therapeutic effect of the drug:

Regenerating – stimulates the restoration of damaged areas of cartilage tissue by increasing the intensity of the synthesis of proteoglycans, which are one of the structural components.
Reducing the processes of degeneration (destruction) of connective tissue.
Positive effect on metabolic processes in cells and intercellular substance of cartilage tissue.
Reducing the destruction of cartilage tissue, as well as the leaching of calcium from various structures of the musculoskeletal system.
Suppression of the activity of enzymatic systems responsible for the breakdown and destruction of cartilage tissue.
Anti-inflammatory effect that occurs during the chronic course of the pathological process in cartilage tissue.

Chondroxide helps improve joint mobility and reduce pain that develops against the background of osteoarthritis and osteochondrosis.

Dosage forms:

Tablets: from white with a yellow tint to white with a cream tint, inclusions are allowed, with a chamfer and a dividing line (10 pcs. In blister packs, in a cardboard pack of 3, 5, 6, 9 or 10 packs);
Solution for intramuscular administration: colorless or with a slight yellow tint, transparent liquid with the odor of benzyl alcohol (1 ml or 2 ml in glass ampoules, 5 ampoules in strip packs, 1 or 2 packs in a cardboard box);
Ointment for external use 5%: light yellow mass with the smell of dimethyl sulfoxide (30 g or 50 g in aluminum tubes, 1 tube in a cardboard box);
Gel for external use 5%: translucent yellowish mass with a fruity odor (20 g, 25 g, 30 g, 35 g or 40 g in aluminum tubes, 1 tube in a cardboard pack).

Indications for use

What does Chondroxide help with? According to the instructions, the drug is prescribed for the prevention and treatment of degenerative diseases of the joints and spine:

osteoarthritis,
osteocondritis of the spine.

Instructions for use of Chondroxide, dosages of tablets and injections

The tablets are taken orally with a sufficient amount of water.

After 3-5 months the course can be repeated. The doctor determines the duration of the repeated course individually, taking into account the clinical indications of the patient.

Chondroxide injections

The solution is intended exclusively for intramuscular (IM) administration!

initial dose – 1 injection of Chondroxide 100 mg \ 1 time in 2 days.
if well tolerated, after 3 injections the dosage is increased to 200 mg. The course of treatment is 25–35 injections.

After 180 days, the course of the drug can be repeated.

When used in patients undergoing concurrent therapy with indirect anticoagulants, fibrinolytics or antiplatelet agents, regular monitoring of blood coagulation parameters is required.

Ointment

Side effects

The instructions warn about the possibility of developing the following side effects when prescribing Chondroxide:

development of allergic reactions (skin rash, itching, urticaria);
nausea, periodic vomiting;
bleeding at the injection site;
diarrhea.

Contraindications

It is contraindicated to prescribe Chondroxide tablets in the following cases:

pregnancy and breastfeeding;
in childhood;
individual intolerance to the drug and its components.

Caution if you are prone to bleeding.

Contraindications to injections:

thrombophlebitis;
tendency to bleed, bleeding;
age under 18 years;
pregnancy and breastfeeding.

The use of Chondroxide in the form of tablets and injections can increase the effect of antiplatelet agents, indirect anticoagulants, and fibrinolytics.

Overdose

Sometimes diarrhea, nausea, and vomiting occur. With prolonged use in large doses, hemorrhagic rashes may occur.

Chondroxide - tablets with a pronounced chondrostimulating, anti-inflammatory and regenerating effect, used in the complex treatment and prevention of degenerative diseases of the spine and joints. The basis of the drug is chondroitin sulfate, a high-molecular mucopolysaccharide obtained from the cartilage tissue of the trachea of cows. This natural component inhibits the process of destruction of connective tissue, stimulates the production of hyaluronic acid, restores the cartilaginous surfaces of joints, improves the composition and quality of synovial fluid, thereby helping to normalize the functional state of the musculoskeletal system.

Release form and components

Chondroxide belongs to the group of non-steroidal anti-inflammatory and antirheumatic drugs. It is produced in Nizhny Novgorod by the pharmaceutical company Nizhpharm. The drug is available in the form of white or almost white tablets of round, flat-cylindrical shape, divided in the center by a score line. The pills are packaged in blister packs of 10 pieces. Inside one cardboard box there are 10, 30, 50, 60 or 90 tablets and instructions for their use.

The active ingredient of Chondroxide is chondroitin sulfate. Its content in one pill is 0.25 g. The auxiliary components of the drug are magnesium stearate, microcrystalline cellulose, crospovidone, polyvinylpyrrolidone and food additive E470 (calcium stearate).

Action and indications for use

Chondroxide tablets have a complex effect on connective tissue affected by the degenerative process. Its use reduces the severity of inflammation in the joints, improves the production of chondrocytes and synovial fluid, normalizes metabolism in hyaline tissue and restores cartilage damaged by the pathological process. The drug prevents the further progression of osteochondrosis and deforming arthrosis, reduces painful manifestations in the disease-affected areas of the body and eliminates joint stiffness.

Chondroxide is prescribed to patients suffering from degenerative-dystrophic pathologies of the musculoskeletal system. It is effective in treating:

osteochondrosis of the cervical, thoracic and lumbar spine;
deforming arthrosis (osteoarthrosis).

During the period of remission, the drug is prescribed to prevent the listed diseases. To enhance the therapeutic effect, experts often recommend combining the use of chondroitin sulfate-based tablets with the external use of Chondroxide ointment or gel.

Directions for use and contraindications

It is recommended to take Chondroxide as prescribed by a specialist, strictly following the treatment regimen drawn up by him. The tablets should not be chewed or crushed into powder before use. They should be swallowed whole with plenty of liquid. To achieve a lasting therapeutic effect, the drug should be taken for a long time. The average duration of its use is 3–6 months. If necessary, 6 months after completion of therapy, the patient can undergo a second course of treatment, the duration of which must be determined by the doctor.

Before starting to use Chondroxide, the patient needs to make sure that this medicine is not contraindicated for him. Instructions for use prohibit taking the medicine if:

hypersensitivity to any of its substances;
renal failure;
liver failure;
thrombophlebitis;
internal bleeding (including a history);
blood clotting disorders;
pregnancy;
lactation.

There is no information on the safety of using Chondroxide tablets in children and adolescents. For this reason, the medicine is not recommended for use in the treatment of patients under 18 years of age.

Adverse reactions and overdose

The patient should be aware that chondroitin sulfate, which is part of Chondroxide, may cause side effects on the part of the gastrointestinal tract, kidneys and immune system. Common unwanted symptoms that can develop while taking the pills include:

painful manifestations in the abdomen;
belching;
heartburn;
nausea;
vomit;
bowel disorder (constipation or diarrhea);
swelling in the face or lower extremities;
hives;
itching on the skin;
dermatitis;
redness of the skin;
Quincke's edema.

Adverse reactions that occur while taking the medication cannot be ignored. If they appear, the patient should stop taking Chondroxide further and consult a doctor.

When using the tablets in question, the patient should be careful and not exceed the dose prescribed by the specialist. Using the drug in large quantities can lead to an overdose, which is characterized by:

nausea;
vomit;
diarrhea;
hemorrhagic rash.

Emergency treatment for an overdose of the drug consists of gastric lavage and taking medications whose action is aimed at eliminating the symptoms that have arisen.

Drug interactions

When treating with Chondroxide, it should be remembered that it is capable of drug interactions with different groups of drugs, enhancing or weakening their effect:

It is undesirable to use this medication simultaneously with fibrinolytics, antiplatelet agents and indirect anticoagulants, since such a drug combination can disrupt the blood clotting process.
Parallel use of Chondroxide with other non-steroidal anti-inflammatory drugs leads to an increase in their analgesic properties.
Chondroitin sulfate also increases the concentration of tetracycline in the blood plasma and reduces the patient’s need for glucocorticosteroids.

Cost and storage

Chondroxide is freely available; to purchase it at a pharmacy, the patient does not need to present a prescription from the attending physician to the pharmacist. The average cost of the drug is about 600 rubles per package containing 60 pills.

Chondroxide- stimulator of tissue regeneration. It has a chondrostimulating, regenerating, anti-inflammatory effect.
Chondroxide is involved in the construction of the basic substance of cartilage and bone tissue; affects metabolic processes in hyaline and fibrous cartilage. Inhibits the processes of degeneration (destruction) of cartilage and connective tissue; inhibits enzymes that cause damage to cartilage tissue.
The drug stimulates the biosynthesis of proteoglycans, promotes the regeneration of the joint capsule and cartilaginous surfaces of the joints, increases the production of intra-articular fluid, and leads to a decrease in inflammation.
Potentially may inhibit the formation of fibrin thrombi in the synovial and subchondral bloodstream.
Chondroxide slows down the progression of osteoarthritis and osteochondrosis, normalizes metabolism in hyaline tissue, and stimulates regeneration (restorative) processes in articular cartilage. When using the drug Chondroxide®, pain decreases and mobility of the affected joints improves, while the therapeutic effect persists for a long time after the end of the course of therapy.

Indications for use:
A drug Chondroxide recommended for the treatment of degenerative-dystrophic diseases of the joints and spine: treatment and prevention of osteoarthritis, osteochondrosis of the spine.

Mode of application:
Orally, 0.5 g (2 tablets) 2 times a day.
Pills Chondroxide Take with a small amount of water.
The recommended dosage of the initial course is 6 months. It should be taken into account that the therapeutic effect of the drug persists for 3-5 months after its discontinuation, depending on the location and stage of the disease. If necessary, repeated courses of treatment are possible, the duration of which is determined individually.

Side effects:
Possible: allergic reactions, nausea, diarrhea.

Contraindications:
Contraindications to the use of the drug Chondroxide are: hypersensitivity to the components of the drug, pregnancy and lactation.
With caution: in case of bleeding and bleeding tendency.

Pregnancy:
The use of the drug is contraindicated Chondroxide during pregnancy and lactation.

Interaction with other drugs:
It is possible to enhance the effect of indirect anticoagulants, antiplatelet agents, and fibrinolytics.

Overdose:
Symptoms of drug overdose Chondroxide are: rarely - nausea, vomiting, diarrhea; with prolonged use in excessively high doses (more than 3 g/day), hemorrhagic rashes are possible.
Treatment: symptomatic therapy.

Storage conditions:
In a dry place, protected from light, at temperatures up to 20°C.
Shelf life - 2 years.

Release form:
Tablets: 30, 60 pcs. packaged.

Compound:
1 tablet Chondroxide contains chondroitin sulfate - 0.25 g;
excipients: calcium stearate, crospovidone, polyvinylpyrrolidone (povidone), microcrystalline cellulose, basic aqueous magnesium carbonate (magnesium carbonate) - a sufficient amount to obtain a tablet weighing 0.48.

Recently, a variety of diseases of the spine and joints have become increasingly common, and the age of patients who seek medical help is steadily getting younger. Therefore, in pharmacies the range of drugs intended to combat these diseases is extremely large, and almost every year drugs appear on the shelves that help restore the normal structure of cartilage tissue. One of the most popular drugs at the moment is Chondroxide tablets. This is due not only to the fact that it is very effective, but also to its relatively low cost, which makes it accessible to all potential buyers from various social classes.

If we consider the drug Chondroxide, its composition is quite homogeneous; each tablet contains 0.25 grams of chondroitin sulfate as an active substance. It also contains excipients: crospovidone, calcium stearate, magnesium carbonate, microcrystalline cellulose and povidone (polyvinylpyrrolidone). Each tablet weighs 0.48 grams, ranges in color from white with a creamy tint to white with a yellowish tint with small inclusions, and each of them has a chamfer and a score. One package can contain 60 or 30 tablets. This drug is produced in Russia.

Pharmacological properties

The medicine Chondroxide has an anti-inflammatory, regenerating and chondrostimulating effect. Chondroxide takes part in the construction of the basic substance (matrix) of bone and cartilage tissue, and also affects metabolic processes in fibrous and hyaline cartilage. It slows down the course of degenerative processes in connective and cartilage tissue, and inhibits enzymes that affect cartilage tissue and provoke changes in its structure.

This medicine stimulates the biosynthesis of proteoglycans, and also helps the regeneration of the cartilaginous surfaces of the joints and tissues of the joint capsule, reduces inflammation, and increases the production of intra-articular fluid. The drug can prevent the formation of fibrin thrombi in the subchondral and synovial microvasculature, which is important in the process of rehabilitation of patients after traumatic joint injuries.

It has been proven that this drug slows down the progression of such common diseases as osteochondrosis and osteoarthritis, stimulates regeneration processes in articular cartilage, and helps normalize metabolism in hyaline tissue. The drug Chondroxide also improves the mobility of joints affected by the disease and reduces pain. Moreover, the achieved therapeutic effect can persist long after the course of therapy has already ended.

Pharmacokinetics

After a single dose of the tablet at an average dose, the maximum concentration of the drug in the plasma is observed three to four hours later, and in the synovial fluid – after four or five hours. It accumulates in cartilage tissue; the synovial membrane does not prevent its penetration into the joint cavity. The medicine, even after a single dose, is completely excreted by the kidneys (about 24 hours).

Indications and contraindications

This drug is used both for the purpose of prevention and for the treatment of various degenerative-dystrophic pathological processes in the organs of the musculoskeletal system, including osteochondrosis and osteoarthrosis. Of course, before you start using it, you need to consult with an experienced specialist. The fact is that Chondroxide also has contraindications: lactation period, pregnancy and hypersensitivity to any of the components of this drug.

Patients with a history of bleeding and an increased tendency to bleeding should take Chondroxide tablets with caution. During lactation, if there is a need to take this drug, breastfeeding will have to be abandoned for the entire duration of treatment.

It is worth noting that Chondroxide is contraindicated for pregnant women, as it can negatively affect the fetus, causing various developmental defects in the unborn child. That is why a woman should consult a doctor before starting to take any medication. Also, Chondroxide, together with breast milk, can enter the baby’s body and have an adverse effect on him, so you cannot continue breastfeeding a child of any age during treatment.

Side effects

As a rule, this medicine is tolerated quite well. But sometimes side effects such as diarrhea, allergic reactions and nausea are observed. If an allergy occurs, the drug will have to be discontinued.

Almost all drugs have some side effects. True, undesirable consequences from taking medications are observed most often when using maximum doses, with long-term use of the drug, and also if a person is forced to take several different medications at once. If any undesirable effects occur, you need to tell your doctor about it, perhaps he will adjust the dose or simply prescribe another drug.

special instructions

It is possible to enhance the effect of antiplatelet agents, indirect anticoagulants and fibrinolytics used for the prevention and treatment of disorders in the blood coagulation system. Therefore, if the above medications are taken simultaneously with Chondroxide, more frequent monitoring of blood clotting parameters and a detailed coagulogram may be required.

In general, people taking more than two different medications need to remember that they can enhance or weaken the effects of each other. Therefore, in order not to risk your own health, you need to tell your doctor what medications are currently being used. Otherwise, there is a high risk of drug poisoning or loss of treatment effectiveness.

Chondroxide: use and dosage

Take two tablets (500 mg), orally, with a small amount of water. You should drink them twice a day. As a rule, the course of taking this drug should be six months. After the course of treatment is completed, the therapeutic effect of Chondroxide lasts for approximately another three years. This period may vary depending on the stage of the disease and the location of the inflammatory process. If necessary, the doctor may advise you to undergo a second course of therapy, in which case he will determine its duration individually.

For many patients, the negative aspect of treatment with this drug is that it must be taken for quite a long time. Moreover, at the beginning of therapy, obvious positive changes in the patient’s condition may not be observed. It is during this period that some people refuse to continue taking Chondroxide, losing faith in its effectiveness. But such an act is fundamentally wrong - if you are patient and follow medical recommendations, you can get wonderful results.