Instructions for use of tablets and suspensions of nifuroxazide-richter. Nifuroxazide tablets: instructions for use Nifuroxazide richter 100 mg instructions for use
Country of origin
Poland Romania/PolandIntestinal antiseptic. Antidiarrheal drug
Release form
- 90 ml - dark glass bottles (1) complete with a double dosing spoon (2.5 and 5 ml) - packs of cardboard. Yellow film-coated tablets, round, biconvex
Description of the dosage form
- 24 - blisters (1) - packs of cardboard. Suspension for oral administration of yellow color, with a banana smell.
pharmachologic effect
Intestinal antiseptic, a derivative of 5-nitrofuran. Active against most pathogens of intestinal infections (including mutant strains resistant to other antimicrobial agents): gram-positive (Staphylococcus spp.) and gram-negative (Escherichia spp., Citrobacter spp., Enterobacter, Klebsiella spp., Salmonella spp. , Shigella spp., Proteus spp., Yersinia spp.), as well as Vibrio cholerae. He is active against bacteria of the genus Pseudomonas spp., Proteus spp. (Proteus inconstans), as well as strains of subgroup A of the species Providentia alcalifaciens. It is believed that the drug inhibits the activity of dehydrogenases and disrupts protein synthesis in pathogenic bacteria. In average therapeutic doses it has bacteriostatic activity, and in higher doses it acts bactericidal. The effect is manifested from the first hours of treatment. In therapeutic doses, it practically does not disturb the balance of the symbiotic bacterial flora of the intestine; does not cause the development of resistant strains of pathogenic microorganisms and cross-resistance of bacteria to other antimicrobial agents, which allows, if necessary, with generalized infections, to prescribe it in combination therapy with systemic drugs. In intestinal infections of viral origin, it prevents the development of bacterial superinfection.Pharmacokinetics
After oral administration, it is practically not absorbed from the gastrointestinal tract, creating a high concentration of the active substance in the intestine. Due to such pharmacokinetic features, the drug has an exclusively enteral antiseptic effect, does not have systemic antibacterial activity, and does not cause general toxic effects; excreted from the body with feces. The drug does not affect the clinical and biochemical parameters of the blood test.Special conditions
During treatment with Nifuroxazide-Richter, the use of alcoholic beverages is contraindicated, because. alcohol increases the body's sensitivity to the drug and can provoke a disulfiram-like reaction (exacerbation of diarrhea, vomiting, abdominal pain, skin flushing, a feeling of heat on the face and upper body, noise in the head, shortness of breath, tachycardia, a feeling of fear). The drug is not prescribed as monotherapy for the treatment of intestinal infections complicated by septicemia. If there are symptoms of dehydration, in combination with treatment, it is necessary to carry out rehydration therapy (for adults - about 2 liters of fluid per day). During treatment, you should follow a certain diet: do not eat raw fruits and vegetables, juices, spicy and fatty foods. Before prescribing a suspension to infants, it is necessary to exclude their congenital deficiency of enzymes that break down sucrose. Influence on the ability to drive vehicles and control mechanisms Nifuroxazide does not affect the ability to drive vehicles and work with mechanisms.Compound
- 5 ml 1 vial (100 g) nifuroxazide 220 mg 4 g Excipients: carboxypolymethylene, sucrose, sodium hydroxide, citric acid monohydrate, antifoam emulsion (Antifoam F), methyl parahydroxybenzoate, banana flavor (banana essence), purified water. nifuroxazide 100 mg Excipients: colloidal silicon dioxide (Aerosil hydrophilic 200), potato starch, gelatin, talc, magnesium stearate. Film coating composition: hypromellose, titanium dioxide, talc, polyethylene glycol 20,000, quinoline yellow dye
Nifuroxazide indications for use
- - acute and chronic diarrhea caused by intestinal gram-positive bacteria (Staphylococcus spp., Streptococcus spp., Haemophilus influenzae), as well as some gram-negative bacteria (Salmonella spp., Shigella spp., Klebsiella spp., Escherichia coli, Proteus spp., Enterobacter spp. .).
Nifuroxazide contraindications
- - allergy to derivatives of 5-nitrofuran; - children's age up to 2 months; - premature babies; - hypersensitivity to any of the components of the drug.
Nifuroxazide side effects
- Nifuroxazide is well tolerated, side effects were practically not observed. In isolated cases, in the presence of increased individual sensitivity to nifuroxazide, abdominal pain, nausea and increased diarrhea are possible (these symptoms do not require special treatment and discontinuation of the drug).
drug interaction
During treatment with Nifuroxazide-Richter, simultaneous administration of oral agents should be avoided due to the strong adsorption properties of the drug. Since nifuroxazide does not enter the circulatory system, interaction with systemic drugs is unlikely and is not yet known.Overdose
Symptoms of an overdose of the drug are not described. In case of overdose, gastric lavage and symptomatic treatment are recommended.Storage conditions
- store in a dry place
- keep away from children
- store in a place protected from light
Nifuroxazide
International non-proprietary name
Nifuroxazide (nifuroxazide)
Dosage form
Film-coated tablets 200 mg
Compound
One tablet contains
active substance- nifuroxazide, in terms of 100% substance 200 mg
Excipients: microcrystalline cellulose, povidone, lactose monohydrate, calcium stearate,
shellOpadry II Yellow 33G22623: hypromellose, lactose monohydrate, titanium dioxide (E171), polyethylene glycol 3000 (macrogol), triacetin, quinoline yellow (E104), sunset yellow FCF (E110), iron oxide yellow (E172), indigo carmine (E132).
Description
Tablets, film-coated, yellow, oval, with a biconvex surface, with a score on one side of the tablet and the inscription "KMP" on the other side. On the fault, a bright yellow core is visible
Pharmacotherapeutic group
Antidiarrheals. Intestinal antimicrobial and anti-inflammatory drugs. Other intestinal antimicrobials. Nifuroxazide
ATH code A07A X03
Pharmacological properties
Pharmacodynamics. Nifuroxazide is an antimicrobial drug of the 5-nitrofuran group, belongs to intestinal antiseptics. It blocks the activity of dehydrogenases, inhibits the processes of cellular respiration, the cycle of tricarboxylic acids, and also disrupts protein synthesis in a microbial cell. Reduces the production of toxins by microorganisms. In medium therapeutic doses, it exhibits bacteriostatic activity, and in higher doses it acts bactericidal.
The drug is active against gram-positive microorganisms of the family Staphylococcus and Gram-negative microorganisms of the family Enterobacteriaceae (Escherichia, Citrobacter, Enterobacter, Klebsiella, Salmonella, Shigella, Yersinia), as well as Vibrio cholerae. Inactive against bacteria of the genus Pseudomonas and kind Proteus(view Proteus inconstances), as well as strains of subgroup A of the species Providentia alcalifaciens.
Pharmacokinetics. After oral administration, Nifuroxazide is not absorbed from the digestive tract, providing a high concentration of the active substance in the intestine. In blood plasma determine the concentration of traces of the drug; a small amount is detected in the urine unchanged. Excreted with feces. The rate of excretion depends on the dose of the drug taken and the motility of the digestive tract.
Indications for use
Infectious diarrhea in adults, chronic colitis, enterocolitis - as an aid in the complex treatment of intestinal dysbiosis.
Dosage and administration
Nifuroxazide is used orally, regardless of food intake, 1 tablet 4 times a day (daily dose - 800 mg).
The course of treatment - 5 - 7 days.
Side effects
Short-term abdominal pain, nausea, increased diarrhea
Rash, itching.
With the development of hypersensitivity reactions, drug withdrawal is required.
Contraindications
Hypersensitivity to 5-nitrofuran derivatives and / or other components of the drug
Children and adolescents up to 18 years of age
Hereditary fructose intolerance, Lapp-lactase deficiency, glucose-galactose malabsorption
Drug Interactions
Against the background of taking Nifuroxazide, other oral preparations should not be used, which is associated with the strong adsorption abilities of the drug. Nifuroxazide is not recommended for use with drugs with a high alcohol content.
The interaction of Nifuroxazide with other drugs has not yet been studied.
special instructions
The drug is not prescribed as monotherapy for the treatment of intestinal infections complicated by septicemia. If there are symptoms of dehydration in combination with the use of Nifuroxazide, rehydration should be carried out. The volume of fluid administered, the method of administration (per os, intravenously) should correspond to the severity of diarrhea, the age and clinical condition of the patient (for adults - about 2 liters of fluid per day).
The drug contains lactose, so patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not use the drug.
During treatment, you should not eat spicy and indigestible foods, raw fruits, vegetables and juices.
When using Nifuroxazide, the use of alcoholic beverages is contraindicated due to the risk of developing a disulfiram-like reaction, manifested by exacerbation of diarrhea, vomiting, epigastric pain, a feeling of heat in the face and upper body, hyperemia, tinnitus, shortness of breath, tachycardia.
Use during pregnancy or lactation.
The use of the drug during pregnancy is possible if the expected positive effect for the mother outweighs the potential risk to the fetus.
The drug is not excreted in breast milk, so it can be used during breastfeeding.
Application in pediatrics
Nifuroxazide is not prescribed for children and adolescents under 18 years of age.
Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
Nifuroxazide does not affect the reaction rate when driving vehicles or working with mechanisms that require increased attention and rapid mental and motor reactions.
Overdose
Symptoms: unknown.
Treatment: gastric lavage, symptomatic treatment.
Release form and packaging
10 tablets in a blister pack made of PVC film and aluminum foil with printing, lacquered.
1 blister pack, together with instructions for medical use in the state and Russian languages, is put into a pack of cardboard.
Storage conditions
Store in the original packaging, at a temperature not exceeding 25 °C.
Keep out of the reach of children.
Shelf life
Do not use after the expiration date.
Terms of dispensing from pharmacies
On prescription
Manufacturer
JSC "Kyivmedpreparat", Ukraine, 01032, Kyiv, st. Saksaganskogo, 139.
Registration certificate holder
JSC "Kyivmedpreparat", Ukraine
Address of the organization accepting claims from consumers on the quality of products in the territory of the Republic of Kazakhstan:
Representative office of "Arterium" corporation in the Republic of Kazakhstan
Nifuroxazide-Richter. Indications: Diarrhea (acute and chronic) caused by Gram-positive (Staphylococcus and Streptococcus) and some Gram-negative (Salmonella, Shigella, Klebsiella, Escherichia coli) bacteria. Nifuroxazide is an intestinal antiseptic, a derivative of 5-nitrofuran; active against most pathogens of intestinal infections. One tablet of Nifuroxazide contains the active substance: nifuroxazide - 100 mg (Nifuroxazide Richter in tablet form has an identical composition).
NIFUROXAZID RICHTER (NIFUROXAZIDUM RICHTER)
NIFUROXAZIDUM A07A X03 Gedeon Richter
COMPOSITION AND FORM OF RELEASE NIFUROXAZIDE RICHTER:
tab. po 100 mg, No. 24
Nifuroxazide 100 mg
Other ingredients: colloidal anhydrous silicon dioxide, potato starch, gelatin, talc, magnesium stearate, hypromellose, polyethylene glycol, quinoline yellow E 104, titanium dioxide (E171).
No. UA/9060/01/01 from 12/30/2009 to 12/30/2014
susp. d/peroral. approx. 220 mg/5 ml vial 90 ml, with measuring spoon, No. 1
Nifuroxazide 220 mg/5 ml
Other Ingredients: Carbomer 934, Sucrose, Sodium Hydroxide, Citric Acid Monohydrate, Simethicone, Methylparaben, Banana Essence, Purified Water.
No. UA/9060/02/01 from 08.11.2010 to 08.11.2015
PHARMACOLOGICAL PROPERTIES OF NIFUROXAZIDE RICHTER:
pharmacodynamics. Nifuroxazide is an intestinal antiseptic, a derivative of 5-nitrofuran; active against most pathogens of intestinal infections (including mutant strains resistant to other antimicrobial agents). It exhibits a local antibacterial effect in the intestinal lumen against certain types of gram-positive bacteria from the Staphylococcus family and some types of gram-negative bacteria from the Enterobacteriaceae family: Yersinia spp., Escherichia spp., Citrobacter spp., Enterobacter spp., Klebsiella spp., Salmonella spp.
Nifuroxazide does not show antibacterial activity against Proteus vulgaris, Proteus mirabilis and Pseudomonas aeruginosa species.
It is assumed that the drug Nifuroxazide Richter inhibits the activity of dehydrogenases and disrupts protein synthesis in pathogenic bacteria. In medium therapeutic doses, it has bacteriostatic activity, and in higher doses it acts bactericidal. The effect is shown from the first hours of reception. In therapeutic doses, it practically does not disturb the balance of the saprophytic bacterial flora of the large intestine; does not cause the development of resistant strains of pathogenic microorganisms and cross-resistance of bacteria to other antimicrobial agents, which allows, if necessary, in case of generalized infections, to prescribe it in combination therapy with systemic antibacterial drugs. In intestinal infections of viral origin, it prevents the development of bacterial superinfection. The effectiveness of the drug does not depend on the pH in the intestinal lumen.
Pharmacokinetics. After oral administration, it is practically not absorbed in the gastrointestinal tract, creating a high concentration of the active substance in the intestine. Due to pharmacokinetic features, the drug has an exclusively enteral antiseptic effect, does not have systemic antibacterial activity, and does not cause general toxic effects; excreted from the body unchanged in the feces.
INDICATIONS FOR NIFUROXAZIDE RICHTER:
acute and chronic diarrhea of infectious genesis.
APPLICATION OF THE DRUG NIFUROXAZIDE RICHTER:
tablets NIFUROXAZIDE RICHTER
Adults and children over the age of 7 years are prescribed 2 tablets of Nifuroxazide Richter 4 times a day (every 6 hours). The drug is taken orally with a small amount of water, regardless of the meal. The duration of the course of treatment is no more than 7 days.
During the treatment of acute diarrhea, continuous oral or intravenous fluid replacement in the body is mandatory, depending on the general condition of the patient.
Suspension NIFUROXAZIDE RICHTER
The drug Nifuroxazide Richter is taken orally. Shake the suspension bottle thoroughly before use. For dosing, I use a double measuring spoon (included in the package) of 2.5 ml (smaller measuring spoon) or 5 ml (large measuring spoon). 1 smaller measuring spoon per 2.5 ml contains 110 mg of nifuroxazide; 1 large measuring spoon per 5 ml contains 220 mg of nifuroxazide.
Doses for children under the age of 7 years: at the age of 1-6 months - 2.5 ml (1 smaller measuring spoon) 2-3 times a day; from 6 months to 2 years - 2.5 ml (1 smaller measuring spoon) 4 times a day; 2-7 years - 5 ml (1 large measuring spoon) 3 times a day.
Doses for children over the age of 7 years and adults: children over the age of 7 years and adults - 5 ml (1 large measuring spoon) 4 times a day; children over 7 years old can use Nifuroxazide Richter film-coated tablets, 100 mg.
The drug Nifuroxazide Richter is recommended to be taken at regular intervals, regardless of food intake. The course of treatment is 5-7 days. During the treatment of acute diarrhea, continuous oral or intravenous fluid replacement in the body is necessary, depending on the general condition of the patient.
CONTRAINDICATIONS TO THE USE OF NIFUROXAZIDE RICHTER:
hypersensitivity to nifuroxazide and other nitrofuran derivatives or to any of the excipients; Nifuroxazide Richter, tablets 100 mg, is used in children over the age of 7 years, in children under 7 years of age, the drug is used in the form of a suspension; for the suspension also - hereditary galactose intolerance, Lapp lactase deficiency or malabsorption of glucose-galactose; children's age up to 1 month.
SIDE EFFECTS OF NIFUROXAZIDE RICHTER:
occasionally there may be violations of the organs and systems.
On the part of the blood and lymphatic system: in isolated cases - granulocytopenia.
From the gastrointestinal tract: individual cases of hypersensitivity to nifuroxazide are manifested by transient abdominal pain, nausea, vomiting and exacerbation of diarrhea. In the event of the appearance of such symptoms of slight intensity, there is no need for special therapy or discontinuation of nifuroxazide, since the symptoms quickly disappear. If the exacerbation is severe, you should stop taking nifuroxazide. In the future, the patient should not take nifuroxazide and other nitrofuran derivatives.
On the part of the skin and subcutaneous tissue: rarely there are reactions in the form of a skin rash, itching. In isolated cases - pustulosis (in an elderly patient), persistent papular urticaria (in the presence of a contact allergy to nifuroxazide).
Hypersensitivity reactions: in isolated cases, urticaria, shortness of breath were noted - conditions requiring discontinuation of the drug.
SPECIAL INSTRUCTIONS:
before the appointment of Nifuroxazide Richter in the form of oral suspension in infants, it is necessary to exclude congenital deficiency of enzymes that break down sucrose.
Nifuroxazide is not recommended for more than 7 days. In the case of ongoing diarrhea for more than 3 days from the start of treatment, an in-depth diagnosis is necessary to determine the cause of the development of symptoms. Antibiotic therapy may be needed.
The drug is not prescribed as monotherapy for the treatment of intestinal infections complicated by septicemia. In the case of severe invasive diarrhea, an antibiotic should be prescribed, since nifuroxazide is not absorbed from the gastrointestinal tract.
In the event of a hypersensitivity reaction (shortness of breath, skin rash, itching), the drug should be discontinued.
During treatment, you should adhere to a certain diet: exclude juices, raw vegetables and fruits, spicy and hard-to-digest foods.
The preservative methylparaben (E218) can cause a delayed-type allergic reaction.
The drug contains sucrose, which must be taken into account when using it in patients with diabetes mellitus.
During treatment with nifuroxazide, you should not drink alcoholic beverages due to the possibility of developing disulfiram-like reactions, which are manifested by exacerbation of diarrhea, vomiting, abdominal pain, skin flushing, a feeling of heat, tinnitus, shortness of breath, tachycardia, a feeling of fear.
Use during pregnancy and lactation of the drug Nifuroxazide Richter
Pregnancy period.
There are no clinical data regarding the use of nifuroxazide during pregnancy. Animal studies do not show any direct or indirect effects on the course of pregnancy, the development of the embryo or fetus, or the course of childbirth. The physician should carefully evaluate the benefit / risk ratio when prescribing nifuroxazide during pregnancy.
breastfeeding period.
It is known that nifuroxazide is not absorbed from the gastrointestinal tract. However, due to the lack of sufficient clinical data, caution should be exercised when prescribing nifuroxazide to women who are breastfeeding.
Children.
Nifuroxazide Richter, 100 mg tablets, is used in children over the age of 7 years. In children under the age of 7 years, the drug is used in the form of a suspension. In the form of a suspension, the drug is not prescribed to children under the age of 1 month.
The ability to influence the reaction rate when driving vehicles and working with other mechanisms. Nifuroxazide does not affect the reaction rate when driving vehicles or working with other mechanisms.
INTERACTIONS:
simultaneous (at the same time) intake of other oral drugs (including sorbents) should be avoided due to the strong adsorption properties of nifuroxazide.
During treatment with nifuroxazide, you should not drink alcoholic beverages because of the possibility of developing a disulfiram-like reaction, which is manifested by exacerbation of diarrhea, vomiting, and abdominal pain.
OVERDOSE:
symptoms of an overdose with Nifuroxazide Richter are unknown. In case of overdose, gastric lavage and symptomatic treatment are recommended.
STORAGE CONDITIONS:
at a temperature not higher than 25 °C.
Save to social networks:Nifuroxazide is an antimicrobial drug. It is an intestinal antiseptic that has an antidiarrheal effect. It is available in suspension, capsules and tablets, which allows it to be used not only for the treatment of adults, but also for children. According to strict indications, Nifcroxazide can be used in pregnant women.
Description and composition
The drug is produced by several companies, therefore, depending on the manufacturer, it may have a different composition of excipients.
The drug contains nifuroxazide as an active ingredient.
In addition to it, the composition of the tablets manufactured by Ternopharm OJSC includes the following auxiliary components:
- aerosil;
- potato starch;
- gelatin;
- E553b;
- E572;
- hypromellose;
- macrogol;
- quinoline yellow;
- titanium white.
Suspension JSC "Ternopharm" contains the following auxiliary components:
- carbopol;
- sucrose;
- sodium hydroxide;
- water;
- banana essence;
- E 218;
- E 330.
Tablets of 100 mg of JSC "Borisov Plant of Medical Preparations" yellow. They are covered with a thin film membrane, have a round, biconvex shape.
As excipients, the composition of the tablets includes the following components:
- aerosil;
- gelatin;
- potato starch;
- E 572;
- E 553b;
- polyvinyl alcohol;
- polyethylene glycol;
- E 171;
- E 104;
- E 172.
Capsules JSC "Vertex" Russia are hard yellow gelatin, they contain a yellow powder or a mixture of granules that can be pressed, but when pressed with a glass rod, they disintegrate.
As auxiliary components, they contain corn starch, sucrose and E 572.
Most of the microorganisms that cause intestinal diseases are sensitive to the drug, such as:
- salmonella;
- staphylococci;
- enterobacter;
- escherichia coli;
- cholera vibrio;
- klebsiella;
- shigella;
- yersinia.
Nifuroxazide is not active against Pseudomonas and some strains of Proteus. Depending on the dosage, the drug may exhibit a bacteriostatic and bactericidal effect. The mechanism of action of the antibiotic is associated with the suppression of the activity of the enzyme dehydrogenase, as a result, the formation of proteins by bacterial cells is disrupted. The drug, taken in medium dosages, does not inhibit the growth and reproduction of normal intestinal microflora, and pathogenic microorganisms do not develop resistance to it. When viruses became the cause, taking Nifuroxazide prevents the addition of a secondary bacterial infection.
After oral administration, the antibiotic is not absorbed in the stomach, resulting in a high concentration of nifuroxazide in the intestine. Due to its pharmacokinetics, the drug enters the blood in a small amount and does not have a systemic effect. The antibiotic is excreted from the body through the intestines.
Pharmacological group
Nifuroxazide belongs to the group of intestinal antiseptics, antimicrobial agents of nitrofuran derivatives.
Indications for use
for adults
Nifuroxazide is prescribed for the treatment of the following diseases:
- intestinal dysbacteriosis;
- indigestion caused by antibiotic-sensitive microorganisms;
- chronic colitis and electrolytes.
The drug is used to prevent infections during abdominal operations.
for kids
According to the indications, the suspension can be used in children older than 2 months, tablets and capsules from 6 years of age.
In the case when the benefit to the mother outweighs the harm to the child, an intestinal antiseptic can be used during pregnancy and lactation.
Contraindications
Nifuroxazide can not be drunk with individual intolerance to the composition of the drug.
Applications and doses
for adults
for kids
For children, the dosage of the medicine is selected depending on age. For patients younger than 6, the drug is given in suspension, which must be shaken before each use.
Children aged 2 to 6 months are prescribed a medicine of 0.5-1 tsp. (110-220 mg) 2 times a day, at the age of 6 months to 6 years, appoint 1 tsp. (220 mg) 3 times a day.
For children over 6 years of age, the medication is prescribed in dosages for adults.
for pregnant women and during lactation
For pregnant and lactating patients, the drug is prescribed as usual.
Side effects
As a rule, the drug is well tolerated by patients, but sometimes it can cause dyspepsia and loose stools. This does not require discontinuation of therapy.
You need to stop drinking the drug if an allergy occurs.
Interaction with other drugs
Nifuroxazide has high adsorption properties, this must be taken into account when taken simultaneously with other drugs.
Interaction with systemic drugs is impossible, since the antibiotic is found in the blood only in trace amounts.
special instructions
If the patient has signs of septicemia, then the drug should not be prescribed as monotherapy. If there are signs of dehydration in combination with antimicrobial therapy, it is necessary to eliminate the symptoms of dehydration.
During treatment, it is necessary to completely abandon the intake of alcoholic beverages, as a hypersensitivity reaction may develop, which is accompanied by an increase in heart rate, a feeling of fear, fever, respiratory failure, dyspeptic disorders, and redness of the skin.
The drug does not affect the speed of the psychomotor reaction and its use is not a contraindication to driving.
Overdose
To date, no cases of overdose with Nifuroxazide have been reported. When taking the drug in dosages higher than recommended, the stomach should be washed.
Storage conditions
The optimum temperature for storing the medicine is from 17 to 25 degrees. Nifuroxazide should be protected from children, moisture and direct sunlight.
Analogues
There are many complete analogues of the drug Nifuroxazide on sale, which contain the same active substance:
- - intestinal antiseptic, which is produced by JSC "Bosnalek", Bosnia and Herzegovina. The drug is available in capsules and suspensions. The main difference from Nifuroxazide is that the suspension can be prescribed to children older than 1 month, and capsules to patients older than 3 years. The drug is not absorbed into the systemic circulation and therefore can be used by pregnant and lactating patients.
- - French drug, which is available in capsules of 200 mg. It can be prescribed to patients older than 3 years. Despite the fact that in the experiments the drug did not have a teratogenic effect, it is not recommended to take it during pregnancy, since there is not enough experience in treating this group of patients. It is possible to use the drug in short courses during breastfeeding.
- Elufor is a Russian drug that is available in suspension and capsules. It can be used in children older than 1 month and during breastfeeding. Eluphor should not be prescribed to women in position, as there is not enough experience in the treatment of such patients.
- Mirofuril - intestinal antiseptic, produced in Russia. It is available in capsules and tablets. Mirofuril should not be prescribed to premature newborns and children under 1 month of age. For a short time it can be drunk during lactation, but it is not recommended for pregnant women to take the medication.
In addition to the complete analogues of the drug Nifuroxazide, there are its substitutes for the pharmacological group:
- - an antimicrobial agent that is used for intestinal infections. The drug is available in tablets. It can be prescribed to children older than 4 years. penetrates the placental barrier and is excreted through the mammary glands, so it is allowed to be taken during pregnancy and lactation according to strict indications.
- - antidiarrheal drug, which is available in the form of a powder for suspension. The drug can be used for diarrhea of various origins, heartburn, bloating. The drug is not absorbed from the digestive tract and can be used to treat patients of all ages, pregnant and lactating women.
- - adsorbent and antidiarrheal agent, which contains diosmectite as an active ingredient. The drug is not absorbed from the digestive tract and is excreted unchanged from the body, so it can be taken during the period of gestation and lactation, as it does not adversely affect the child. It is allowed to give to children of any age, including those younger than a year. Smecta can be used for diarrhea of both infectious and non-infectious origin. In addition, the drug helps with heartburn and bloating.
You can take an analog instead of Nifuroxazide only after consulting with your doctor.
Price
The cost of Nifuroxazide averages 167 rubles.
In this article, you can read the instructions for using the drug Nifuroxazide. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Nifuroxazide in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Nifuroxazide analogues in the presence of existing structural analogues. Use for the treatment of diarrhea (diarrhea) in adults, children (including infants), as well as during pregnancy and lactation. Interaction of the drug with alcohol.
Nifuroxazide- antidiarrheal drug. Nifuroxazide - a derivative of nitrofuran, has an antibacterial effect against gastrointestinal gram-positive bacteria (Staphylococcus spp., Streptococcus spp.) And some gram-negative bacteria (Salmonella spp., Shigella spp., Klebsiella spp., Escherichia coli). Does not affect the composition of the normal bacterial flora of the large intestine. The detailed mechanism of action of the drug is unknown.
Nifuroxazide presumably inhibits the activity of dehydrogenases and protein synthesis in bacterial cells. It does not cause the emergence of drug-resistant strains, and cross-resistance to other antibacterial drugs was not observed.
The effectiveness of nifuroxazide does not depend on the pH existing in the intestinal lumen, nor on the sensitivity of microorganisms to antibacterial drugs. The drug is practically not absorbed from the digestive tract, it acts exclusively in the intestinal lumen.
Compound
Nifuroxazide + excipients.
Pharmacokinetics
Nifuroxazide is difficult to dissolve. After oral administration, it is practically not absorbed from the gastrointestinal tract, creating a high concentration of the active substance in the intestine. Due to such pharmacokinetic features, the drug has an exclusively enteral antiseptic effect, does not have systemic antibacterial activity, and does not cause general toxic effects; excreted from the body with feces.
The drug does not affect the clinical and biochemical parameters of the blood test.
Indications
- acute and chronic diarrhea caused by intestinal gram-positive bacteria (Staphylococcus spp., Streptococcus spp., Haemophilus influenzae), as well as some gram-negative bacteria (Salmonella spp., Shigella spp., Klebsiella spp., Escherichia coli, Proteus spp., Enterobacter spp. ).
Release form
Suspension for oral administration 4% (sometimes erroneously called syrup or solution).
Film-coated tablets 100 mg Richter.
Instructions for use and dosing regimen
Suspension
The drug is used inside. Before use, shake the bottle thoroughly until a homogeneous suspension is obtained.
Children from 2 months to 6 months: 1-2 measuring spoons per 2.5 ml 2 times a day;
Children from 6 months to 6 years: 1 measuring spoon per 5 ml 3 times a day;
Children over 6 years: 1 measuring spoon per 5 ml 4 times a day;
Adults: 1 measuring spoon per 5 ml 4 times a day.
One 2.5 ml measuring spoon contains 110 mg of nifuroxazide. One 5 ml measuring spoon contains 220 mg of nifuroxazide.
Tablets
Adults and children over 6 years of age are prescribed 2 tablets (200 mg) 4 times a day after 6 hours. The course of treatment is 6 days. Before use, you should consult with your doctor.
Side effect
- abdominal pain;
- nausea;
- increased diarrhea;
- dyspnea;
- skin rashes;
Contraindications
- allergy to 5-nitrofuran derivatives;
- children's age up to 2 months;
- premature babies;
- hypersensitivity to any of the components of the drug.
Use during pregnancy and lactation
There are no data on adverse effects on the fetus when using the drug during pregnancy. If necessary, with caution, the drug can be prescribed to pregnant women and women who are breastfeeding.
Use in children
It can be used according to indications and in doses that take into account the age of the patient. Tablets are contraindicated in children under the age of 6 years.
special instructions
During treatment with Nifuroxazide, the use of alcoholic beverages is contraindicated, because. alcohol increases the body's sensitivity to the drug and can provoke a disulfiram-like reaction (exacerbation of diarrhea, vomiting, abdominal pain, skin flushing, a feeling of heat on the face and upper body, noise in the head, shortness of breath, tachycardia, a feeling of fear).
The drug is not prescribed as monotherapy for the treatment of intestinal infections complicated by septicemia.
If there are symptoms of dehydration, in combination with treatment, it is necessary to carry out rehydration therapy (for adults - about 2 liters of fluid per day).
During treatment, you should follow a certain diet: do not eat raw fruits and vegetables, juices, spicy and fatty foods.
Before prescribing a suspension to infants, it is necessary to exclude their congenital deficiency of enzymes that break down sucrose.
Influence on the ability to drive vehicles and control mechanisms
Nifuroxazide does not affect the ability to drive vehicles and work with mechanisms.
drug interaction
During treatment with Nifuroxazide, simultaneous administration of oral agents should be avoided due to the strong adsorption properties of the drug.
Since nifuroxazide does not enter the circulatory system, interaction with systemic drugs is unlikely and is not yet known.
Analogues of the drug Nifuroxazide
Structural analogues for the active substance:
- Ecofuril;
- Enterofuril;
- Ercefuril.
In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.