Can I drink alcohol after taking cetirizine. Cetrin and alcoholic drinks. Use in elderly patients

Zodak is a second-generation antiallergic drug that is prescribed for manifestations of allergies to alleviate the patient's condition and get rid of the symptoms of an allergic reaction.

At the same time, experts do not recommend combining the Zodak and alcohol. This combination can lead to side effects. Most often, when taken simultaneously, lethargy and a desire to sleep are manifested.

The main active ingredient of the drug is cetirizine dihydrochloride. It is he who negatively affects the reactions of the body caused by external stimuli. Upon contact with the allergen, histamine begins to be produced there, which causes unpleasant signs of allergy (itching, sneezing, tearing, etc.)

Zodak suppresses the production of histamine by blocking nerve endings. The drug is most effective at the initial stage of contact with the allergen.

Also, this pharmacological agent is able to reduce capillary permeability, and this prevents the occurrence of bronchospasm. Experts recommend taking the remedy in advance, before contact with an external irritant occurs.

To date, the drug can be seen in three dosage forms: syrup, tablets and drops. Syrup and drops are great for young children, while tablets are great for adults.

The drug does not cause addiction. It also does not have a sedative effect.

When is it applied?

The main indications for taking the drug are:

allergic rhinitis of seasonal and year-round nature;
dermatitis and dermatoses caused by allergies;
hives;
hay fever (pollinosis);
angioedema.

The action begins a quarter of an hour after ingestion, and the effectiveness lasts about 24 hours.

Patient reviews suggest that the drug is really quite effective, especially during the spring flowering period, when many are faced with allergies.

How to use?

Zodak tablets are allowed to be taken at any time of the day without reference to food intake. They should be swallowed whole with plenty of clean water. In acute manifestations of an allergic reaction, doctors advise taking pills at the same time of day, for example, at 8 am and 8 pm.

Adults and children over 12 years of age take one tablet per day. You can split the tablet into two parts and take it twice a day.

It is more convenient for young children to take drops. The medicine should be taken once every 24 hours for 20 drops. Children 1-2 years old give medicine 5 drops twice a day, 6-12 years old - 10 drops twice a day.

The syrup is not as popular as tablets or drops. You can use it for both children and adults, two scoops a day. Its plus is that even people with diabetes can drink it, because. it contains a sweetener, not sugar.

Contraindications

Zodak should not be drunk in such cases as:

pregnancy and lactation;
individual intolerance to the main active substance or additional components;
the age of the child is up to one year old;
non-allergic cough;
severe chronic diseases of the kidneys, liver;
disorders in the work of the kidneys;
co-administration with drugs that depress the work of the central nervous system.

Compatibility of medication and alcoholic beverages

Like any other drug, this antiallergic drug should not be combined with alcoholic beverages. It is allowed only if the amount of alcohol does not exceed 0.5 g / l in the blood. At the same time, it is worth refraining from driving a vehicle and work that requires concentration.

Adverse reaction after simultaneous use

During the simultaneous use of the drug and ethyl alcohol, a disulfiram-like reaction may occur. The components of the product react with ethanol molecules and cause intoxication. It may present with the following symptoms:

vomiting and nausea;
skin redness;
increased body temperature;
high blood pressure;
tachycardia;
hard breath;
headache;
cramps of the limbs;
acute pain in the stomach;
puffiness;
fainting state.

Also, in some cases, ethyl alcohol inhibits the work of the drug, as a result of which free histamines continue to be produced in the same way and increase the signs of the disease.

In order to avoid the development of possible negative consequences, it is worth completely abandoning the use of alcoholic beverages while taking the drug.

In medical practice, cases have been recorded in which patients with a disease such as alcoholism after taking antihistamines and a large amount of ethyl alcohol fell into a coma.

What to do in case of violation?

In cases where alcohol was still consumed during treatment, it is necessary:

Stop drinking alcohol.
Drink as much water as possible for the next 4 hours.
Carefully read the contraindications in the instructions for use of the medicine and follow them.
If this happens only once and the dose of alcohol consumed is small, the harm to health will be minimal.
If the state of health has deteriorated sharply, it is necessary to seek help from a doctor as soon as possible.

Remember, no matter what dosage form the drug was taken in, its combination with alcohol can cause negative consequences.

How long can you drink alcohol?

Drinking alcohol-containing drinks is allowed in a minimum amount a day after the drug was drunk.

If the doctor prescribed a course of treatment or the drug was used by the patient for several days (weeks) in a row, then drinking alcoholic beverages is allowed at least after three days, in some cases after a month. This is due to the fact that the substances of the drug are able to accumulate in the tissues of the body for a certain time and, if ethyl alcohol enters, they will react with its molecules. Such compatibility can lead to a deterioration in well-being.

Cetirizine is a 2nd generation antiallergic (antihistamine) drug with a rapid onset of action and a long duration. The use of the drug is justified in cases where long-term treatment of allergic diseases is necessary: chronic urticaria, year-round. The drug prevents the development and facilitates the course of allergic reactions, has antipruritic and antiexudative action. Available in the form of tablets, drops and syrup for oral administration.

Composition and form of release

Cetirizine (CETIRIZINE) is an antiallergic drug. Histamine H1 receptor blocker. The medicine is included in the list of necessary medicines and is dispensed without a prescription.

Cetirizine excipients include:

colloidal silicon dioxide;
lactose monohydrate;
crospovidone;
magnesium stearate;
microcrystalline cellulose:
shell: hypromellose, polydextrose, macrogol, titanium dioxide.

pharmachologic effect

The perception of the drug by the body begins already at the stage of its ingestion. Actively absorbed by the upper layer of the epidermis and mucous membranes, when it enters the oral cavity and then into the intestines, the active substance causes a decrease in the activity of allergy manifestations.

Virtually no anticholinergic and antiserotonin action. In therapeutic doses, it practically does not cause a sedative effect. The onset of action after a single dose of 10 mg of cetirizine is after 20 minutes (in 50% of patients) and after 60 minutes (in 95% of patients), lasts more than 24 hours. During the course of treatment, tolerance to the antihistamine action of cetirizine does not develop. After stopping treatment, the effect persists for up to 3 days.

The drug is able to prevent and reduce the skin reaction that occurs when histamine is released and when specific allergens penetrate the skin.

Indications

What helps? According to the instructions, Cetirizine is indicated in the following cases:

, including chronic idiopathic;
allergic conjunctivitis;
seasonal and year-round allergic rhinitis (as a symptomatic treatment);
dermatoses that occur with itching, including atopic dermatitis.

The drug can also be prescribed to patients who are prone to developing allergic reactions to drugs, such as antibiotics, cough syrups and others.

With extreme caution Cetirizine is prescribed to the elderly and to persons suffering from chronic pyelonephritis of the middle and severe stages.

Instructions for use

To achieve the maximum effect, it is necessary to take Cetirizine tablets correctly. An analogue should also be used after carefully studying the instructions. The drug is taken orally. You do not need to chew the tablets. Wash them down with plenty of water. The medication can be used regardless of the meal. On an empty stomach, the rate of absorption of tablets increases.

Cetirizine tablets

Tablets are taken orally, whole, preferably in the evening, given the sedative effect. Adults and children from 12 years of age are prescribed 10 mg per day. Children 6-12 years old with a weight of more than 30 kg - 10 mg 1 time per day, with a weight of less than 30 kg - 5 mg 1 time per day.

Drops Cetirizine

Use Cetirizine orally, regardless of food intake.

Instructions for use for children and adults:

Adults and adolescents over 12 years of age are recommended to take 20 drops (10 mg) daily, preferably in the evening.
Children aged 6-12 years: 10 drops (5 mg) twice daily in the morning and evening or 20 drops (10 mg) in the evening.
Children aged 2-6 years: 10 drops (5 mg) in the evening or 5 drops (2.5 mg) in the morning and evening.
Children aged 1-2 years: 5 drops (2.5 mg) twice a day.

Due to the inhibitory effect of Cetirizine on the central nervous system, this drug in the form of drops should be with extreme caution prescribe to children under one year of age who have established factors that increase the risk of SIDS - sudden infant death syndrome.

Syrup

Cetirizine syrup in dark glass bottles of 75 or 150 ml, complete with a measuring spoon of 5 ml, together with instructions for use in a cardboard box.

Children from two to 12 years old and weighing less than 30 kg are prescribed in a dose of 5 ml, if the weight is greater, then 10 ml of the drug per day is needed. Patients over 12 years old need a daily dosage of 10 ml. It is possible to take 2 times a day (morning and evening) 5 ml (1 scoop).

In case of renal insufficiency, the recommended dose should be reduced by 2 times.

Contraindications

Cetirizine should be administered with caution to the elderly, as this category of patients may have a decrease in glomerular filtration. In addition, care must be taken when prescribing the drug for chronic pyelonephritis of the middle and severe stages.

The official instructions indicate that the drug contraindicated in pregnancy.

Side effects for the body

Usually, the drug Cetirizine is normally tolerated by patients, but with an incorrectly calculated dose, hypersensitivity to the components of the tablet, or prolonged uncontrolled use of the drug, side effects may develop:

dry mouth;
dyspepsia;
headache;
drowsiness;
fatigue;
dizziness;
excitation;
migraine;
skin rash;
angioedema;
hives;
skin itching.

With caution, the drug Cetirizine-Teva is used in patients with chronic renal failure of moderate and severe severity, in elderly patients (glomerular filtration may be reduced).

With severe side effects, it is recommended to stop taking this drug and replace it with analogues in action.

Overdose

Excessive use of the above drug can provoke the development of the following symptoms:

drowsiness,
lethargy,
urinary retention,
general weakness,
headache,
tachycardia,
increased fatigue and irritability.

special instructions

According to the instructions, cetirizine is prohibited for use during pregnancy and lactation.

Interaction with other drugs

No clinically significant interactions of cetirizine with other drugs have been established.

Expiry date of tablets

Store the drug in a dry, dark place at a temperature not exceeding 25°C.

Tablets, drops and syrup: store for 3 years. An open vial can be used within 6 months.

Do not use the medicinal product after the indicated expiration date.

Analogues

The most common and most effective analogues of cetirizine are:

cetirinax,
Tsetrin,
analergin,
Alercetin
Zodak.

Before replacing the prescribed drug with its analogue, you should read the attached instructions for contraindications and age restrictions.

Prices in pharmacies

The approximate cost of Cetirizine is shown in the table:

Before using the drug, be sure to consult your doctor.

The presented table is built on the basis of data obtained from the websites of pharmaceutical companies for a particular drug. To avoid possible health risks, give up alcohol for the entire period of treatment. Effects Combining with alcohol, cetirizine can lead to a disulfiram-like reaction. Antibiotic molecules come into contact with ethanol, which leads to intoxication that can react to the body with symptoms: nausea and vomiting, severe headache, fever and redness of the neck, face, chest, heart palpitations, heavy and intermittent breathing, cramps in the arms and legs. About Doses In the calculations of the table, the average indicator of the drunk was taken (average degree of intoxication), calculated in proportion to the body weight of 60 kg. Alcohol that can affect the drug includes: beer, wine, champagne, vodka and other strong drinks. Even 1 dose of alcohol can affect the drug in the body. For 1 dose drunk for different drinks, it is considered to be:

In case of incompatibility

1. Stop drinking alcohol. 2. Drink more water for the next 4 hours. 3. In the annotation to the medicine, read the item - contraindications, and follow them. 4. If the medicine was taken as a course of treatment, alcohol is contraindicated for use from 3 days to 1 month. 5. It doesn't matter which form of cetirizine is taken with alcohol, both the tablet and the ointment will have an effect. 6. If this happens for the first time, the risk of harm to health is minimal. 7. See your doctor for more help and advice.

Excessive alcohol consumption is harmful to your health! The collection and verification of information are carried out by professionals in the field, within their competence. The data indicated in the table cannot be absolutely accurate, because. possible individual characteristics of the organism were not taken into account. The information contained on the page should not be used by patients to make an independent decision on the use of the presented drugs with strong drinks and does not serve as a substitute for an in-person consultation with a doctor.

Cetirizine is an antihistamine drug, a blocker of histamine H1 receptors. The second generation remedy allows you to alleviate the symptoms characteristic of an allergic reaction and prevent its development. There is a list of contraindications for use.

Tablets. They are oblong and white in color.
Drops for oral administration. They are odorless and colorless.
Syrup (the most preferred form for children). Transparent composition with banana flavor.

The optimal dosage form is determined by the attending physician in a particular case for a particular patient.

Description and composition

One tablet of the drug contains 10 mg of cetirizine dihydrochloride. Auxiliary components are:

lactose monohydrate;
cellulose microcrystalline;
titanium dioxide;
colloidal silicon dioxide;
magnesium stearate.

The drug in the form of drops contains 10 mg of cetirizine dihydrochloride per 1 ml of the composition. Among the list of auxiliary components are the following compounds:

sodium acetate trihydrate;
benzoic acid;
propylene glycol;
glycerol;
distilled water.

The composition of the syrup for oral administration contains 1 mg of cetirizine dihydrochloride in 1 ml of the medicinal composition. Additional components are the following connections:

glycerol;
sodium saccharin;
banana flavor;
sorbitol;
acetic acid;
sodium acetate;
propylene glycol.

Pharmacological group

Cetirizine can be classified as a histamine H1 receptor blocker. the agent has a pronounced antihistamine effect on the human body. When taken in acceptable dosages, the active substance does not have a sedative, antiserotonic, and anticholinergic effect. The drug is used to eliminate the symptoms of an allergic reaction and prevent its manifestation. The tool has an anti-exudative effect: it eliminates the flow from the nose, prevents tearing, and also has an antipruritic effect. Effective in the fight against contact allergies.

At an early stage in the development of allergies, the active substance can reduce the rate of migration of inflammatory cells, at a later stage it can stop the rate of release of mediators. According to the instructions for use, the drug begins to act 1 - 1.5 after oral administration.

Indications for use

The drug is prescribed to patients for the relief and prevention of symptomatic manifestations of an allergic reaction. The tool can be used to eliminate the symptoms of an allergic reaction caused by food intake or contact with an external irritant.

for adults

The drug can be prescribed to patients with the following conditions:

allergic rhinitis provoked by external stimuli;
allergic, accompanied by swelling of the eyelids and lacrimation;
allergic;
allergic reaction to sunlight;
cold dermatitis;
active mucus formation in the oral cavity;
generalized pruritus;
response to an insect bite.

The agent can be used to prevent the manifestation of an allergic reaction in a patient while taking antibacterial agents.

for kids

Cetirizine tablets are prescribed to children over the age of 12 years with the following contraindications:

allergic rhinitis;
manifestation of rashes on areas of the skin and mucous membranes;
allergic swelling of the mucous membranes.

Dosage for children under 12 years of age is determined privately.

Children over the age of 1 year are prescribed a drug in the form of drops to combat various symptoms of an allergic reaction. A remedy in the form of a syrup can be used to stop attacks of allergic reactions in children older than 2 years.

Clinical trials and studies on the effects of cetirizine on the fetus during fetal development have not been conducted. Since the safety of the drug has not been proven in clinical trials, the drug is not prescribed to pregnant women.

The active component of the antiallergic agent has the ability to penetrate into breast milk, therefore, the agent must not be used during breastfeeding. If it is necessary to use the medicinal composition, the question of the possibility of stopping breastfeeding should be resolved.

Contraindications

The drug Cetirizine, regardless of the form of release, can be used orally after carefully studying the instructions for use, which regulate the recommended dosages and exclude the possibility of a reaction of the body.

The list of contraindications for taking the composition includes:

violations in the work of the kidneys, accompanied by severe organ dysfunction;
children's age up to 6 years;
period of pregnancy and lactation;
private susceptibility of the patient's body to the components of the drug;
lactose intolerance;
liver failure;
disturbances in the work of the central nervous system;
advanced age of the patient - more than 65 years;
heart rhythm disturbances.

The drug is prescribed with caution to patients suffering from chronic.

Applications and doses

The dosage of the agent is determined on an individual basis, depending on the age of the patient and the form of release of the composition used.

for adults

Adults are prescribed the drug Cetirizine in the form of tablets. The drug has a prolonged action. therefore, the permissible daily dose is 1 tablet. The drug in the form of a syrup for adults and children over the age of 12 is prescribed 10 ml per day. Cetirizine in the form of drops for oral administration - 20 drops per day. Patients suffering from renal insufficiency are shown to adjust the permissible dose.

The duration of treatment for seasonal allergies is from 3 to 6 weeks.

for kids

The daily dose of Cetirizine syrup for children aged 2 to 12 years weighing less than 30 kg is not more than 5 ml per day. If the weight of the child is over 30 kg, the dose should be increased to 10 ml.

Oral drops are recommended for children under two years of age. The allowable dose is 5 drops per day. For children aged 2 to 6 years, the dose is 10 drops. For the age group from 6 to 12 years, the dose is 20 drops per day.

for pregnant women and during lactation

The composition is not used during pregnancy and breastfeeding.

Side effects

Adverse reactions from the functioning of various body systems are extremely rare and with low intensity.

From the side of the digestive tract, the following symptoms can be observed:

feeling of heaviness in the abdomen;
dry mouth;
loss of appetite;
nausea;
digestive disorders.

From the side of the nervous system, the following symptoms may appear:

constant sleepiness;
prostration;
lethargy and apathy;
headache;
increased irritability.

Cardiovascular disorders:

heart rhythm failures;
pain in the retrosternal space;
decrease in blood pressure;
shortness of breath.

The manifestation of these symptoms is a reason for an unscheduled visit to a specialist. The doctor will adjust the dose or select a drug with better tolerance.

Interaction with other drugs

Cetirizine should not be used in combination with Theophylline. The latter has the ability to reduce the intensity of the process of purification of biological fluids and tissues in the human body.

It is not recommended to use Cetirizine in combination with sorbents, because against the background of their consumption, the effectiveness of the antihistamine may decrease. It is important to remember that cetirizine has the ability to enhance the effectiveness of sedatives and antidepressants.

special instructions

The list of special instructions is as follows:

With caution, an antiallergic agent is prescribed to elderly patients.
You should not combine taking the drug with the consumption of alcoholic beverages.
The drug in the form of tablets is not prescribed to children under the age of 12 years.
Cetirizine affects the reaction rate in the patient, therefore, during the period of consumption of the medicinal composition, work with complex mechanisms and driving a vehicle should be abandoned.

Overdose

With an overdose of cetirizine, the intensity of side effects increases. To eliminate the symptoms, you should stop taking the drug, wash the patient's stomach and prescribe an enterosorbent. If the patient's condition is critical, an emergency team should be called. is a substitute for Cetirizine in the therapeutic group. The drug is available in syrup and tablets. An antihistamine can be given to children older than 6 months. It is not suitable for patients who are expecting a baby or breastfeeding.

The cost of the drug is an average of 103 rubles. Prices range from 43 to 254 rubles.

Formula: C21H25ClN2O3, chemical name: -1-piperazinyl]ethoxy]acetic acid (and as hydrochloride).
Pharmacological group: intermediates / histaminergics / histaminolytics / H1-antihistamines.
Pharmachologic effect: antiallergic, antihistamine.

Pharmacological properties

Cetirizine selectively blocks peripheral H1-histamine receptors, reduces the effect of histamine on blood vessels, and reduces edema and hyperemia. Cetirizine effectively slows down the development of skin reactions (hyperemia and wheal) to the introduction of specific allergens, histamine, cooling (in patients with cold urticaria). The effect develops within 1-2 hours after taking cetirizine, the duration of blockade of H1 receptors is more than 1 day, in children under 2 years old - about 12 hours. Within 3 days, the reactivity of the skin to histamine is restored. Cetirizine relieves the symptoms of allergic rhinitis (runny nose, sneezing, nasal congestion, watery eyes, itching). The drug dose-dependently reduces the narrowing of the bronchi in mild bronchial asthma, which is caused by histamine. Slows down the development of the early phase of an allergic reaction mediated by histamine. It inhibits the migration of neutrophils, eosinophils and basophils, the secretion of mediators that take part in the late phase of an allergic reaction in response to the introduction of an allergen. Cetirizine inhibits the action of other mediators and inducers of histamine secretion, such as substance P and platelet-activating factor, reduces the expression of adhesion molecules (VCAM-1, ICAM-1). Cetirizine reduces the fluidity of the membranes of neutrophils, eosinophils and platelets, which are obtained from patients with seasonal allergic rhinitis and healthy volunteers.

The use of cetirizine for 1 week at doses that are 6 times the therapeutic daily dose was not accompanied by a change in the QT interval on the ECG and other signs of cardiotoxic effects. In doses of 20–25 mg/day, cetirizine does not affect the ability to concentrate and reaction time. In experimental studies, no effect on fertility and mutagenic effects were noted. When administered to rats for 2 years, 20 mg / kg / day of the drug, no carcinogenic effect was found. In mice that received 16 mg/kg/day of the drug (6 times the MRHD), cetirizine increased the incidence of benign liver tumors. The administration of the drug to mice during lactation was accompanied by a slowdown in weight gain in the offspring.

When taken orally, cetirizine is absorbed by at least 70% and quickly. The maximum plasma concentration is 0.3 μg / ml and is achieved within 1 hour when 10 mg of the drug is taken orally. Food does not affect the completeness of absorption, but can increase the time to reach the maximum concentration by 1.7 hours and reduce it by 23%. The mean maximum concentration and AUC are proportional to the dose of the drug. Cetirizine binds to plasma proteins by 93%. The volume of distribution is 0.56 l/kg. 3 days after the start of administration, a stable plasma level is reached. With repeated use, the content of cetirizine in serum and skin is equivalent. The maximum concentration in the brain is not more than 10% of the maximum concentration in plasma. Cetirizine is excreted in breast milk. The half-life of cetirizine is 7-11 hours when using a single dose of 10 or 20 mg (in the elderly, the half-life is lengthened, in children 2-12 years it is shortened to 5-6 hours). In the liver, cetirizine is minimally metabolized with the formation of an inactive metabolite and is excreted mainly by the kidneys unchanged. 60% of the dose taken during the day is excreted in the urine, 10% - in the faeces. The clearance of cetirizine is 54 ml/min.

With daily use of 10 mg of the drug for 10 days, its accumulation in the body does not occur. According to the test of inhibition of the skin reaction (hyperemia and wheal) to the introduction of histamine intradermally with prolonged use of the drug (up to 110 weeks), the development of tolerance is not observed. In case of violation of the functional state of the kidneys (with creatinine clearance less than 11–31 ml / min) and in patients who are on hemodialysis (with creatinine clearance below 7 ml / min), the half-life of cetirizine is extended by 3 times, its clearance is reduced by 70% . In chronic liver diseases and in elderly patients, there is an increase of 50% in the half-life of cetirizine and a decrease in its clearance by 40%. The pharmacokinetic parameters of cetirizine do not depend on race and gender.

Indications

Year-round and seasonal allergic rhinitis; allergic conjunctivitis; hay fever; chronic idiopathic urticaria; angioedema; skin itching; complex treatment of chronic eczema, atopic dermatitis, atopic bronchial asthma.

Route of administration of cetirizine and dose

Cetirizine is taken orally (regardless of food intake), patients older than 6 years - 2 times a day, 5 mg or 1 time per day 10 mg, patients 2–6 years old - 2 times a day, 2.5 mg or 1 time per day 5 mg (depending on the response or severity of the condition), children 1–2 years old - 2.5 mg twice a day, children 0.5–1 years old - 2.5 mg once a day. For patients with renal insufficiency, depending on creatinine clearance, the dose is reduced: with creatinine clearance of 30-49 ml / min - 5 mg once a day, at 10-29 ml / min - 5 mg every other day.

The concomitant use of drugs that depress the central nervous system (including alcohol) with cetirizine is not recommended. Use with caution during work for drivers of vehicles and people whose professions are associated with increased concentration of attention.

Contraindications for use

Hypersensitivity (including to hydroxyzine), lactation, pregnancy, age up to 6 months.

Application restrictions

Old age, moderate and severe chronic renal failure.

Use during pregnancy and lactation

The use of cetirizine during pregnancy is contraindicated. During therapy with cetirizine, breastfeeding should be discontinued.

Side effects of cetirizine

Sense organs and nervous system: drowsiness, agitation, fatigue, headache, anxiety, dizziness, migraine, nervousness, impaired thinking and concentration, emotional lability, insomnia, euphoria, depression, confusion, depersonalization, amnesia, ataxia, tremor, impaired coordination of movements, hyperkinesis, paresthesia , spasms of the calf muscles, dysphonia, paralysis, myelitis, ptosis, impaired vision and accommodation, eye pain, xerophthalmia, glaucoma, eye hemorrhage, conjunctivitis, deafness, tinnitus, ototoxicity, impaired sense of smell;
digestive system: dry mouth, absence or change in taste perception, anorexia, increased appetite, stomatitis (including ulcerative), swelling and discoloration of the tongue, increased caries, increased salivation, thirst, dyspepsia, vomiting, gastritis, flatulence, abdominal pain, diarrhea, hemorrhoids, constipation, melena, violation of the functional state of the liver, rectal bleeding;
circulatory system: very rarely - heart failure, hypertension, palpitations;
respiratory system: rhinitis, nasal polyp, epistaxis, pharyngitis, sinusitis, cough, bronchitis, bronchospasm, increased bronchial secretion, upper respiratory tract infection, dyspnea, hyperventilation, pneumonia;
urinary system: edema, urinary retention, polyuria, hematuria, dysuria, urinary tract infection, decreased libido, cystitis, dysmenorrhea, menorrhagia, intermenstrual bleeding, vaginitis;
support and movement system: arthralgia, arthrosis, arthritis, myalgia, muscle weakness, back pain;
skin covers: dry skin, blisters, rash, itching, furunculosis, acne, dermatitis, hyperkeratosis, eczema, erythema, alopecia, increased sweating, angioedema, photosensitivity, hypertrichosis, seborrhea;
others: fever, malaise, chills, dehydration, hot flashes, breast pain, lymphadenopathy, weight gain, diabetes mellitus, allergic skin reactions, including urticaria.

Interaction of cetirizine with other substances

Theophylline reduces the clearance of cetirizine by 16%. Cetirizine is compatible with pseudoepinephrine, azithromycin, ketoconazole, diazepam, erythromycin and cimetidine.

Overdose

With an overdose of cetirizine, drowsiness appears, urinary retention, anxiety, tachycardia, tremor, rash, itching are possible. Necessary: gastric lavage, activated charcoal, symptomatic and supportive treatment; hemodialysis is ineffective.