Norfloxacin eye and ear drops. Norfloxacin drops instructions for use. Application restrictions

Norfloxacin (norfloxacin)

Composition and form of release of the drug

Film-coated tablets white or almost white, round, biconvex; two layers are visible on the break - the core from white to light yellow and the film shell.

Excipients: lactose monohydrate - 85 mg, microcrystalline cellulose - 98 mg, croscarmellose sodium - 37 mg, water - 10 mg, K25 - 24 mg, magnesium stearate - 6 mg.

The composition of the film shell: hypromellose - 11 mg, macrogol-4000 - 3 mg, titanium dioxide - 6 mg.

10 pieces. - cellular contour packings (1) - packs of cardboard.
10 pieces. - cellular contour packings (2) - packs of cardboard.
10 pieces. - cellular contour packings (3) - packs of cardboard.
10 pieces. - cellular contour packings (4) - packs of cardboard.
10 pieces. - cellular contour packings (5) - packs of cardboard.
10 pieces. - cellular contour packings (10) - packs of cardboard.
20 pcs. - cellular contour packings (1) - packs of cardboard.
20 pcs. - cellular contour packings (2) - packs of cardboard.
20 pcs. - cellular contour packings (3) - packs of cardboard.
20 pcs. - cellular contour packings (4) - packs of cardboard.
20 pcs. - cellular contour packings (5) - packs of cardboard.
20 pcs. - cellular contour packings (10) - packs of cardboard.
5 pieces. - polymer cans (1) - packs of cardboard.
10 pieces. - polymer cans (1) - packs of cardboard.
20 pcs. - polymer cans (1) - packs of cardboard.
30 pcs. - polymer cans (1) - packs of cardboard.
40 pcs. - polymer cans (1) - packs of cardboard.
50 pcs. - polymer cans (1) - packs of cardboard.
100 pieces. - polymer cans (1) - packs of cardboard.

pharmachologic effect

From the side of the central nervous system: headache, dizziness, fatigue, sleep disturbances, irritability, anxiety.

Allergic reactions: skin rash, itching, angioedema.

From the side of the urinary system: interstitial nephritis.

drug interaction

With the simultaneous use of norfloxacin, the anticoagulant effect of the latter is enhanced.

With the simultaneous use of norfloxacin with cyclosporine, an increase in the concentration of the latter in the blood plasma is noted.

With the simultaneous administration of norfloxacin and antacids or preparations containing iron, zinc, magnesium, calcium or sucralfate, the absorption of norfloxacin is reduced due to the formation of chelators with metal ions (the interval between their administration should be at least 4 hours).

When taken simultaneously, norfloxacin reduces clearance by 25%, therefore, with simultaneous use, the dose of theophylline should be reduced.

Simultaneous administration of norfloxacin with drugs with the potential to reduce blood pressure can cause a sharp decrease in blood pressure. In this regard, in such cases, as well as with the simultaneous administration of barbiturates, anesthetics, heart rate, blood pressure, ECG indicators should be monitored. Simultaneous use with drugs that reduce the epileptic threshold may lead to the development of epileptiform seizures.

The instructions for Norfloxacin eye drops indicate that they are used for diseases of the organs of vision, accompanied by inflammatory processes.
It is also used in otorhinolaryngology to eliminate otitis media.

They are especially popular. The drug Norfloxacin, produced in the form of drops, belongs to fluoroquinols and has a bactericidal effect.

Indications for use

For the treatment of inflammatory processes of the visual apparatus and some ear diseases, a remedy is produced in the form of Norfloxacin drops. One vial contains a clear, colorless or slightly greenish liquid for topical use. The volume of the bottle is 5 ml. It comes with a drip tip for more comfortable use.

As long as the product is in sealed packaging, it can be stored for 2 years. After opening the bottle, drops are allowed to use no more than 10 days.

For the treatment of inflammatory processes affecting the organs of vision, the following treatment regimen is followed:

If the symptoms are pronounced, it is necessary to drip 1-2 drops of the drug into each eye every 20-30 minutes. When the symptoms subside, the procedure is performed less frequently - 4-5 times a day. It is recommended to use Norfloxacin for 2 days even after the disappearance of all symptoms.
For moderate symptoms, Norfloxacin is used every 4-12 hours.
With trachoma (chlamydial eye damage) 3-4 times a day for 1-2 months.

With the disappearance of symptoms, norfloxacin drops are used for another 2 days to finalize the result.

Norfloxacin is a representative of the so-called broad-spectrum antibiotics. This is a universal drug that copes with any bacteria.

Typically, such drugs are used in cases where there is no time left to determine the pathogen, since the disease is rapidly progressing. They are also prescribed in the presence of extensive infections.

Medications containing broad-spectrum antibiotics are appropriate for:

pathogen resistance to other antibiotics;
the presence of an infection caused simultaneously by several bacteria;
as preventive measures after surgical procedures to prevent possible complications.

Norfloxacin eye drops help fight:

conjunctivitis and keratoconjunctivitis;
blepharitis and blepharoconjunctivitis;
keratitis;
dacryocystitis;
trachoma;
ulcerative lesions of the cornea;
inflammation of the meibomian glands (meibomitis).

Norfloxacin is also given to people who have had a foreign body removed from their eye.

Norfloxacin is often prescribed at the end of surgery.

Therapeutic effect of drops

The main component of the drug is the substance norfloxacin, which contains 3 mg in 1 ml of the solution. Auxiliary components are presented:

Due to the effect of the drug, the doubling of the hereditary material of pathogenic microorganisms is blocked, as a result of which their reproduction stops and they die.

The antibiotic Norfloxacin is active against Gram-positive and Gram-negative bacteria:

enterococci;
staphylococci;
streptococci;
enterobacteria;
escherichia;
Klebsiella;
pseudomonads;
proteus;
salmonella;
shigella;
yersinium.

The drug is resistant to enzymes secreted by pathogens, which makes the drug more active for treatment.

With local use of drops, the effect of the drug begins within one hour. The accumulation of the medicinal substance lasts 2 days, after which its concentration reaches a maximum.

Special instructions and interaction with other drugs

Norfloxacin in liquid form is used only topically. If you combine eye drops and systemic antimicrobial therapy in the form of tablets inside, you can achieve the maximum effect.

It has been noted that as a result of prolonged and uncontrolled use of Norfloxacin, microorganisms may lose their susceptibility to it, which will lead to an increase in their number. Therefore, it is recommended to use Norfloxacin as prescribed by a doctor, with strict adherence to the course of treatment.

It is necessary to use the drops as carefully as possible when:

epilepsy;
convulsive syndromes of non-epileptic origin;
severe renal / hepatic disorders;
atherosclerotic lesions of cerebral vessels.

After using Norfloxacin, it is advisable to refrain from driving for half an hour and from work that requires increased attention.

If simultaneous use of eye drops with other topical ophthalmic preparations is envisaged, it is better to adhere to a 15-minute break between procedures.

When Norfloxacin is combined with Warfarin, the anticoagulant (anti-blood clotting) effect of the latter is enhanced. A sharp decrease in blood pressure is not excluded if the drug is taken with antihypertensive drugs. With the simultaneous use of an antibiotic and drugs from the group of nitrofurans, the effect of taking the latter is reduced.

Analogues of this drug

When the drug is not suitable for the patient for certain reasons, the specialist will definitely select analogues of the drug, among which there may be both expensive medicines and more affordable ones.

You can replace Norfloxacin with such drugs:

Tobrex. Eye drops with an antibiotic from the aminoglycoside group, which has a bactericidal and bacteriostatic effect. Effectively copes with most pathogens with inflammation of the organs of vision.
Vigadex. As part of an antibiotic from the group of fluoroquinolones.
Nettacin. As part of a semi-synthetic antibiotic of the aminoglycoside group - netilmicin. The drug is allowed to be used from 3 years of age.
Dex-Gentamicin. The combined remedy for the eyes, has an antibacterial, anti-inflammatory and anti-allergic effect. Before use, you must familiarize yourself with the contraindications, since Dex-Gentamicin is prohibited for some eye pathologies.
Ciprofloxacin. It is produced in the form of drops and tablets and has the same effect as Norfloxacin. Among its advantages is a low price, but an imported drug will cost more.

Features of the use of the drug

Before you start instillation of the eyes, you must thoroughly wash your hands with soap and water. If the patient has crusts or purulent discharge in the eye area, they will need to be removed first.

After the introduction of drops into the eyes, the doctors advise the patient to refrain from driving for half an hour. It is necessary to stop wearing lenses for the duration of treatment.

To make it more convenient to carry out manipulations, the patient should lie on his back or simply tilt his head.

During pregnancy and breastfeeding

The annotation to the drug says that Norfloxacin is one of the drugs that are prohibited during childbearing and breastfeeding. Such a ban is explained by the fact that the placenta is not an obstacle to the absorption of an antibiotic from the fluoroquinol group, so the child may suffer.

However, pregnancy and lactation are not an absolute contraindication. The drug can be prescribed in case of emergency, if the benefit from it exceeds the possible harm to the baby. When an antibiotic is prescribed for a breastfeeding woman, the baby should be switched to formula.

Appointment of funds for children under 15 years of age

You can drip medicine to patients from the age of 15. However, there are often reviews about the use of Norfloxacin in children of an earlier age. The main thing is not to use the remedy without the permission of the doctor.

Overdose and side effects

When using Norfloxacin drops, some patients may complain of the occurrence of negative symptoms, which may be accompanied by:

skin rashes;
angioedema;
increased sensitivity to sunlight;
itchy sensations;
burning sensation;
puffiness;
eye discomfort.

Sometimes, during treatment with Norfloxacin, exudative erythema appears, which is characterized by the formation of a specific rash (red spots) on the skin and mucous membranes.

Also, in severe cases of individual hypersensitivity, manifestation is possible:

bitterness in the mouth;
nausea;
heartburn;
pain in the abdomen;
dizziness;
anxiety.

In medical practice, there are no cases associated with an overdose of Norfloxacin when applied topically.

During therapy, photophobia (photophobia) may develop. Wearing sunglasses is recommended.

If taking Norfloxacin is accompanied by skin rashes or other negative manifestations that indicate excessive sensitivity to the components, treatment should be stopped and the doctor should be informed.

Sometimes a significant increase in the concentration of a substance (with combined local and general use) inside the body, due to non-compliance with the rules of use, turns into anaphylactic shock or Quincke's edema.

Contraindications to the use of the drug

Be sure to carefully read the instructions for the drug. The antibiotic Norfloxacin, prescribed to effectively eliminate eye diseases, has contraindications that are undesirable to ignore. The medicine is allowed to be used by patients from 15 years of age.

In the list of patients for whom Norfloxacin is not recommended, there are those who suffer from individual intolerance to the components of the drug.

Relative contraindications are:

epilepsy and convulsive syndromes of a different origin;
atherosclerosis of cerebral vessels;
hepatic and renal disorders.

It is important to exercise special care when using Norfloxacin and drugs prescribed for convulsive manifestations, since they have low compatibility rates.

As for women who are carrying a child and breastfeeding, the use of Norfloxacin is possible only if the risk is fully justified and the drug is prescribed by the attending physician.

Norfloxacin is a broad-spectrum antibacterial drug from the group of fluoroquinolones with bactericidal properties.

Release form and composition

Dosage forms of Norfloxacin:

Film-coated tablets: biconvex, round, yellow, in a cross section, the core is light yellow (5 pcs in a blister blister pack, in a carton pack 2 or 4 packs; 10 pcs in a blister blister pack, in a carton a pack of 1 or 2 packs, 20 pcs in a blister strip pack, 1 pack in a carton pack, 10 pcs in a polyethylene can, 1 can in a carton pack);
Eye and ear drops: a clear, colorless or pale greenish liquid (5 ml each in bottles with a dropper cap, 1 bottle in a carton box).

Active substance: norfloxacin - 400 mg per 1 tablet; 3 mg/ml solution.

Additional components:

Film-coated tablets: magnesium stearate, colloidal silicon dioxide, povidone, croscarmellose sodium, microcrystalline cellulose;
Film shell: yellow iron oxide, titanium dioxide, talc, hyprolose, hypromellose;
Eye and ear drops: buffer solution, disodium edetate, decamethoxin, sodium chloride, purified water.

Indications for use

Prostatitis, cystitis, urethritis, pyelonephritis and other infections of the urinary system, in acute and chronic form;
Gonorrhea;
cervicitis;
endometritis;
travelers diarrhea;
Salmonellosis, shigellosis.

Tablets are also prescribed: to prevent recurrence of lesions of the genitourinary tract; for the prevention of infections during surgical interventions and instrumental diagnostic procedures in urological practice; for the prevention of sepsis (in patients with granulocytopenia).

Drops eye and ear

In ophthalmology: blepharitis, conjunctivitis, keratitis, blepharoconjunctivitis, dacryocystitis, corneal ulcers, acute inflammation of the meibomian glands; infections after removal of foreign bodies from the cornea or conjunctiva, chemical burns;
In otolaryngology: otitis externa, otitis media (acute and chronic form).

Drops are also used in operations on the organs of vision and hearing to prevent infectious complications.

Contraindications

Terminal stages of renal failure;
Liver failure;
Deficiency of glucose-6-phosphate dehydrogenase;
Age up to 15 years;
Pregnancy and lactation period;
Hypersensitivity to the components of the drug and other drugs of the fluoroquinolone series.

Method of application and dosage

Film-coated tablets

Tablets are taken orally 2 hours before meals, swallowed whole and washed down with water in sufficient quantities.

The dosage regimen is prescribed individually depending on the indications, the patient's condition and the tolerability of the drug. A single dose is usually 400-800 mg (1-2 tablets) divided into 1-2 doses. Adolescents over 15 years of age are prescribed the same doses as adults.

In the treatment of urinary tract infections, it is recommended to take 400 mg (1 tablet) 2 times a day for 7-10 days; for the treatment of uncomplicated cystitis, the course is 3-7 days; in chronic recurrent forms of urinary tract infections - up to 3 months.

For the treatment of gonococcal urethritis, proctitis, cervicitis, the drug is taken once at 800 mg (2 tablets).

To prevent diarrhea, travelers are recommended to take the drug at a daily dose of 400 mg the day before departure and throughout the trip (no more than 3 weeks).

In order to prevent bacterial gastroenteritis, the drug is prescribed at a dose of 400 mg 1 time per day, sepsis - 2 times a day.

To prevent recurrence of lesions of the urinary tract, take 200 mg of the drug per day.

Patients on hemodialysis, as well as with creatinine clearance below 20 ml / min, are prescribed 2 times a day for ½ of the recommended therapeutic dose, or 1 time a day for a full dose.

Drops eye and ear

Drops are used mainly in combination with systemic antibiotic therapy. Before use, the liquid should be warmed to body temperature.

For eye lesions, the drug is administered 1-2 drops. In the case of acute infectious diseases, instillations are carried out every 15-30 minutes (their frequency is further reduced), with moderately pronounced processes - no more than 6 times a day. For the treatment of trachoma, 2 drops are prescribed 2-4 times a day for 1-2 months.

In diseases of the ear after the sanitation of the external auditory canal, the drug is administered 2-5 drops up to 3 times a day. To facilitate the introduction of the drug, the patient is advised to lie on his side or tilt his head and keep it in this position after instillation for 2 minutes. In the future, you can put a cotton turunda in the ear canal.

After the disappearance of signs of infection, the drops must be used for another 2 days.

Side effects

Digestive system: loss of appetite, bitterness in the mouth, nausea, diarrhea, abdominal pain or cramps, dysbacteriosis, pseudomembranous colitis, increased activity of hepatic transaminases;
Nervous system: insomnia or drowsiness, dizziness, headache; rarely - disorientation, convulsions, hallucinations; in old age - fatigue, irritation, tinnitus, depression, anxiety, a sense of fear;
Urinary system: profuse urination, dysuria, bleeding from the urethra, crystalluria, glomerulonephritis, increased plasma levels of creatinine and urea, the appearance of protein in the urine;
Skin: itching, rash, urticaria, edema, photosensitivity, toxic epidermal necrolysis, malignant exudative erythema;
Musculoskeletal system: pain in the joints, ruptures and inflammation of the tendons;
Cardiovascular system: tachycardia, arrhythmia, vasculitis, arterial hypotension;
Allergic reactions: respiratory failure, anaphylaxis, Quincke's edema;
Organs of hematopoiesis: leukopenia, thrombocytopenia, eosinophilia, neutropenia;
Local reactions: swelling and hyperemia of the conjunctiva, pain or burning sensation, photophobia.

When taking Norfloxacin orally, in case of an overdose, it is necessary to induce vomiting or perform a gastric lavage with a probe, ensure that a large amount of fluid enters the body (to prevent crystalluria), and establish control over water-salt metabolism. Treatment is symptomatic.

There are no reports of drug overdose in otology and ophthalmology.

special instructions

With extreme caution, the drug should be used for atherosclerosis of cerebral vessels, functional disorders of the liver / kidneys, epilepsy.

During therapy, it is necessary to consume a sufficient amount of fluid (under the control of diuresis).

When combining norfloxacin with antacids, as well as preparations containing calcium, magnesium, zinc, iron or sucralfate, the interval between their intake should be at least 2 hours.

Against the background of therapy, an increase in the prothrombin index may be observed (if surgical intervention is necessary, monitoring of the state of the blood coagulation system is required).

You should immediately stop taking the drug and consult your doctor if you experience allergic reactions, pain in the tendons, signs of bronchospasm.

After the introduction of drops into the eyes for the next 30 minutes, it is necessary to refrain from driving vehicles or other complex mechanisms.

During treatment, prolonged exposure to direct sunlight should be avoided.

drug interaction

Mutual influence of norfloxacin and drugs / substances when they are used simultaneously:

Theophylline - increases its level in the blood, reducing clearance by 25%;
Cyclosporine - helps to increase its concentration in serum;
Warfarin - enhances its anticoagulant effect;
Drugs that lower the epileptic threshold - may contribute to the development of epileptiform seizures;
Antacids, drugs that include calcium, magnesium, iron, zinc or sucralfate - reduce the absorption of norfloxacin;
Drugs that have an antihypertensive effect - can lead to a sharp decrease in blood pressure;
Nitrofurans - reduces their effectiveness;
Caffeine - slows down the period of its excretion from the body.

When combining norfloxacin with antihypertensive drugs, anesthetics, barbiturates, it is required to control the heart rate, blood pressure, and electrocardiogram parameters.

Terms and conditions of storage

Store in a place protected from light, out of the reach of children. Tablets - at a temperature not exceeding 25 ° C, drops - from 15 to 25 ° C. The shelf life of drops after opening the bottle is no more than 10 days.

Shelf life - 2 years.