Prednisolone side effects: tingling in hands. Prednisolone is a controversial drug. General characteristics. Compound

The drug "Prednisolone" has long been used in the treatment of a large number of diseases, but the attitude of patients towards it is ambivalent. No matter how effective the drug Prednisolone may seem, the side effects of its use can have a negative impact on many organs of the body, since this drug is a systemic drug.

Prednisolone is prescribed as an anti-inflammatory drug; it is effective due to its antipruritic and antiallergic effects. Supervision during treatment by a specialist is mandatory; independent use is strictly not recommended. When prescribing Prednisolone, the doctor describes the side effects of the drug and gives instructions that should be followed during treatment.

With short-term use of the drug, side effects do not have a destructive effect on the body and disappear without a trace. If treatment with the drug requires a long period, complex problems are possible. The main danger is that the drug "Prednisol" is a hormonal drug of artificial origin, and the body gets used to it, stopping the production of some of its own hormones. A replacement process is taking place. The principle of action of prednisolone is that the drug actively mobilizes all body systems, sharply increasing the rate of water-salt metabolism. At the same time, potassium and nitrogen ions are removed, sodium and water begin to accumulate, blood sugar levels rise, fats accumulate, and the person gains excess weight.

When taking prednisolone, side effects can be observed in the functioning of the endocrine glands. When children are depressed, they begin to lag in growth, in women the cyclicity of the menstrual cycle is disrupted, and the body begins to experience a lack of insulin.

The cardiovascular system suffers. Prednisolone provokes an exacerbation of chronic heart failure, and scars on the myocardium heal more slowly.

Possible disturbances in the functioning of the musculoskeletal system and gastrointestinal tract. Muscle mass decreases, muscle sagging appears, bones become more fragile, and osteoporosis develops. Ulcers may open in the stomach. Taking Prednisolone is accompanied by bloating, nausea and vomiting, as well as a sharp increase in appetite.

Pigment spots may appear on the face, and the mental state becomes unstable. Euphoria gives way to depression, insomnia, headaches appear, visual acuity decreases, and sudden loss of vision is even possible.

When taking prednisolone, you should take into account its interactions with other medications so as not to aggravate the course of other diseases. The drug reduces the effectiveness of sedatives and individual doses of the drug should be selected by a medical specialist, taking into account the mutual influence of all drugs taken on the body and on each other.

No less dangerous is the combination of the drug Prednisolone and alcohol. Both of these substances increase blood pressure, while alcohol promotes the absorption of toxic substances. In the treatment of alcoholic cirrhosis of the liver is prescribed

Contraindications include a wide range of diseases and functional conditions of the body. For short-term use, individual intolerance to the drug is important. If treatment involves a long period, underlying diseases should be taken into account. Thus, external use of the drug is contraindicated for skin diseases of fungal and viral origin, open wounds and ulcers on the skin, and under 2 years of age. Administration of the drug directly to the site of inflammation requires the study of joint diseases.

The drug "Prednisolone", whose side effects and contraindications indicate the possibility of its negative effects on the body, also has an excellent therapeutic effect. Therefore, treatment with the drug requires constant monitoring of the body’s condition, regular testing and monitoring of blood pressure.

Dosage form

Tablets 5 mg

Compound

One tablet contains

active substance – prednisolone 5 mg,

excipients: magnesium stearate, talc, corn starch, lactose monohydrate, pregelatinized starch.

Description

The tablets are white, round in shape, flat on both sides with beveled edges, with engravings “PD” and “5.0” and a line between them.

Pharmacotherapeutic group

Corticosteroids for systemic use. Glucocorticoids. Prednisolone.

ATX code H02AB06

Pharmacological properties

Pharmacokinetics

Suction:
Prednisolone, when taken orally, is quickly and completely absorbed from the gastrointestinal tract (up to 85% of the dose), bioavailability is lower at higher doses. Maximum plasma concentrations are reached after approximately 1-2 hours. However, the maximum biological effect is achieved much later (usually no earlier than 4-8 hours).
Food intake slows down the achievement of the maximum concentration of prednisolone in the blood plasma, but does not affect the overall bioavailability.

Distribution:
As a rule, the binding of prednisolone is 90-95%, which mainly occurs with corticosteroid binding globulin (transcortin), as well as with plasma albumin when saturation of transcortin occurs.
Only 5-10% of prednisolone is in unbound form and is biologically active.

Metabolism:
Prednisolone is the main active metabolite of prednisone. Prednisolone is primarily metabolized in the liver; 25% is excreted unchanged through the kidneys.

Elimination:
The biological half-life is 18-36 hours. The half-life from blood plasma is 2–4 hours, which is reduced by drugs that induce liver enzymes.

Pharmacokinetics in special groups of patients:

In patients with severe liver disease (hepatitis, cirrhosis), the clearance of prednisolone is lower and the half-life is longer. The free active fraction may increase significantly in patients with liver disease associated with hypoalbuminemia. In patients with severe liver dysfunction, bioavailability may also be reduced.

Pharmacodynamics:

Prednisolone 5 mg tablets is a corticosteroid with glucocorticoid, anti-inflammatory, and mineralocorticoid activity, although to a lesser extent. Like other corticosteroids, Prednisolone Nycomed induces several mechanisms, including anti-inflammatory activity, immunosuppressive properties, and antiproliferative effects. Other mechanisms include effects on carbohydrate metabolism, fat distribution, hematologic parameters, calcium excretion, growth, mood, and hypothalamic-pituitary-adrenal axis suppression. The threshold dose for the development of Cushing's syndrome is 7.5 mg/day.

1. The anti-inflammatory effect is achieved by reducing the formation and reduced activity of inflammatory mediators (quinine, histamine, liposomal enzymes, prostaglandins and leukotrienes), reducing the initial manifestations of the inflammatory process. Prednisolone reduces the migration of cells into the affected areas, reduces vasodilation and increased vascular permeability in these areas. The vasoconstrictor effect reduces vascular permeability, as a result of which the movement of blood serum through the walls of blood vessels into the intercellular spaces is reduced and, as a result, swelling and patient complaints are reduced.

2. Immunosuppressive properties reduce the response to delayed and immediate hypersensitivity reactions (types III and IV) by inhibiting toxic antigen-antibody complexes that cause allergic vasculitis in the walls of skin vessels, as well as by inhibiting lymphokines, target cells and macrophages (causing allergic contact dermatitis with joint action).

3. Antiproliferative effects reduce inflammation, expressed by the formation of a crust on the skin, formed as a result of increased proliferative activity of white blood cells - lymphocytes and excessive formation of small capillaries in the superficial skin layer, in dermatological diseases (such as psoriasis).

Indications for use

Pharmacodynamic therapy

Rheumatic diseases, including collagenoses

Allergic diseases (hay fever, bronchial asthma, urticaria, drug allergies)

Respiratory tract diseases: chronic bronchitis (prescribed in conjunction with antibacterial treatment)

Pulmonary fibrosis, sarcoidosis

Ulcerative ileitis/colitis

Proliferative glomerulonephritis (lipoid nephrosis), nephrotic syndrome

Acute severe dermatoses (pemphigus vulgaris, erythroderma, Lyell's syndrome)

Thrombocytopenic purpura, chronic lymphadenosis with autoimmune phenomenon (hemolytic anemia, thrombopenia)

Tumors (used in combination with chemotherapy)

Replacement therapy

Primary adrenal insufficiency (Addison's disease) and hypopituitarism (Sheehan syndrome)

Directions for use and doses

When initiating therapy with any corticosteroid, the following guidelines should be considered and followed. The initial dose should be appropriate to achieve the desired therapeutic effect and will depend on the clinical response. It is necessary to periodically evaluate this dose, since the severity of the underlying disease may change, or complications may develop during therapy. The dose should be gradually reduced to the minimum value while achieving and maintaining a satisfactory clinical response to treatment. It may be necessary to increase the dose during long-term therapy or in case of exacerbation of the underlying disease.

If long-term prednisolone therapy (usually more than 3 weeks) is to be discontinued, withdrawal should be gradual and stepwise to avoid “withdrawal syndrome.” Abrupt cessation of therapy can be fatal. The dose should be reduced over weeks or even months depending on the dose size, duration of therapy, the patient's underlying disease, and the patient's individual response to treatment. It is unlikely that abrupt discontinuation of treatment with Prednisolone Nycomed for less than 3 weeks will result in clinically significant suppression of the hypothalamic-pituitary-adrenal axis in most patients, however, it should be borne in mind that the response to and tolerability of corticosteroid withdrawal may vary widely. Thus, it is necessary to consider a gradual dose reduction when discontinuing drugs after short courses or when taking higher doses and in patients with other risk factors for the development of adrenocortical insufficiency.

The dosage regimen for gradual dose reduction should be selected individually. Most patients tolerate a reduction in the dose of Prednisolone Nycomed by 2.5 mg every 3-7 days until reaching a dose of Prednisolone Nycomed 5-10 mg/day. Higher doses should be reduced gradually over 9-12 months.

When tapering the dose, the evening dose should be skipped first, followed by the midday, afternoon or evening doses, so that eventually only the morning dose is taken after 10 days. Long-term intermittent treatment with glucocorticoid therapy (1 dose every other day in the morning) has shown to be effective due to the lack of suppression of the adrenal cortex.

Directions for use: taken orally with a small amount of liquid after meals.

Adults: The usual dose ranges from 5 to 60 milligrams/day, depending on the disease being treated. In general, the entire daily dose should be taken in the morning between 6 and 8 o'clock. (Circadian therapy - circadian secretory rhythms should be taken into account when prescribing).

Doses for special groups of patients

Dosage in patients with hypothyroidism: Dosage reduction may be necessary in patients with hypothyroidism.

Dosage in patients with hepatic impairment: Patients with hepatic impairment are more likely to develop severe adverse reactions due to decreased protein binding due to hypoalbuminemia. Dose adjustment may be necessary.

Dosage in patients with renal impairment: No dosage adjustment is required in patients with renal impairment.

Dosage in elderly patients: No dose adjustment is required, however, it should be noted that long-term use of corticosteroids in elderly patients may cause exacerbation of diabetes mellitus, hypertension, congestive heart disease, osteoporosis or depression.

Doses for children: no experience of use in children. Children are considered to be particularly at risk for growth retardation, and the indication for use of the drug requires a particularly strict assessment of the condition of children.
In children during the growth period, treatment should generally be periodic or intermittent. A gradual dose reduction to a dose that provides satisfactory clinical response and minimal side effects is necessary.

Anti-inflammatory or immunosuppressive effects: the usual dose of prednisolone is 0.1-2 mg/kg/day. The dose can be divided into 1-4 doses per day. The lowest effective dose is usually determined by clinical response.

Exacerbation of bronchial asthma: usually the dose of prednisolone is 1-2 mg/kg/day; this dose can be divided into 1-2 doses/day for 3-5 days.

Replacement therapy: the usual dose is 4 to 5 mg/m2/day.

Nephrotic syndrome: The usual dose is 2 mg/kg/day (maximum dose 60-80 mg/day), given in 2-4 divided doses.

Side effects

Very often (>1/10), often (>1/100,<1/10), нечасто (>1/1000, <1/100), редко (>1/10000, <1/1000), очень редко (<1/10000), не известно (не может быть оценено на основе имеющихся данных).

In general, the incidence of predicted side effects, including suppression of the hypothalamic-pituitary-adrenal axis, depends on the dose, timing of administration and duration of treatment. Side effects can be minimized by using the lowest effective dose for the shortest possible period of time.

Often

Increased susceptibility to infection, worsening of existing infection, activation of latent infection and masking of symptoms of infection (due to the immunosuppressive and anti-inflammatory effect of prednisolone)

Decrease in the number of eosinophils and lymphocytes

Masking or worsening an existing disease

Adrenal insufficiency (starting with suppression of the hypothalamus and ending with true atrophy of the adrenal cortex) with constant oral use of prednisolone, withdrawal syndrome due to adrenal insufficiency (headache, nausea, dizziness, anorexia, weakness, emotional instability, apathy and inadequate reaction to stressful situations), “steroid diabetes mellitus” with low insulin sensitivity, increased blood sugar levels in patients already suffering from diabetes mellitus (100%), growth retardation in children as a result of impaired secretion of growth hormone and decreased sensitivity to it

Increased intraocular pressure (up to 40% of patients treated with an oral drug), cataracts (in 30% of patients with long-term oral treatment with the drug)

Lung abscess (12%)

Oral candidiasis, especially in patients with cancer (33%)

Fungal infections of mucous membranes (30%)

Osteoporosis manifested by back pain, limited mobility, acute pain, vertebral compression fractures and decreased height, long bone fractures (25% with long-term oral treatment), myopathy (10%) with high-dose treatment

Increased white blood cell and platelet counts

Cushing's syndrome, including changes in the pattern of fat deposition (moon face, trunk obesity, "bull hump") with chronic intake of oral doses higher than physiological (usually more than 50 mg per day), hypokalemia due to sodium retention and potassium excretion, amenorrhea in women of childbearing age, increased levels of cholesterol, triglycerides and lipoproteins when treated with high doses taken orally, increased appetite and weight gain

Euphoria, depression, psychosis (corticosteroid-induced)

Hypertension (due to sodium retention, resulting in fluid retention), worsening congestive heart failure (due to sodium retention)

Increased risk of developing tuberculosis

Increased symptoms and increased risk of developing gastrointestinal perforations, colitis, ileitis, diverticulitis

Stretch marks, acne, bruising, dermatitis, ecchymosis, facial erythema, atrophy, hirsutism, slow wound healing, increased sweating, telangiectasias and thinning of the skin, masking or worsening of existing skin conditions

Increased frequency of nighttime urination

Allergic reactions

Diabetes (<1%) при лечении малыми пероральными дозами, повышение уровня холестерина, триглицеридов и липопротеинов при лечении низкими пероральными дозами

Insomnia, mood swings, personality changes, mania and hallucinations

Myopathy of the respiratory muscles

Ulcers of the stomach or duodenum while taking acetylsalicylic acid or non-steroidal anti-inflammatory drugs (NSAIDs), gastrointestinal bleeding (0.5%), gastrointestinal perforation

Aseptic necrosis of bone tissue

Urinary stones due to increased excretion of calcium and phosphate

Risk of thrombosis due to increased blood clotting

Changes in thyroid function

Possible increased duration of coma in cerebral malaria, cognitive impairment (eg, poor memory), dementia, epidural lipomatosis

High risk of destruction of the cornea with simultaneous herpetic eye infection (due to masking of this infection), glaucoma (with long-term oral treatment with the drug)

Very rarely

Ketoacidosis and hyperosmolar coma, manifestation of latent hyperparathyroidism, tendency to porphyria, tumor lysis syndrome, disorders of sex hormone secretion (menstrual disorders, hirsutism, impotence)

Manifestation of latent epilepsy, pseudotumor cerebri (benign intracranial hypertension with symptoms such as headache, blurred vision and visual disturbances)

Exophthalmos (after long-term treatment)

Cardiomyopathy with risk of decreased cardiac activity, arrhythmias due to hypokalemia, vascular collapse

Pancreatitis (after long-term treatment with high doses)

Epidermal necrolysis, Stevens-Johnson syndrome

Achilles and patellar tendinopathy

Not known

Increased risk of atherosclerosis and thrombosis, vasculitis (may also occur as a withdrawal syndrome after long-term therapy)

Ulcers and candidiasis of the esophagus

Muscle atrophy, tendon diseases, tendinitis, tendon ruptures

Delayed wound healing, loss of appetite

Note:
If the dose is reduced too quickly after long-term treatment, problems such as muscle and joint pain, fever, rhinitis, conjunctivitis and weight loss may develop.

Contraindications

Prednisolone Nycomed is contraindicated in the following conditions/disorders:

Hypersensitivity to Prednisolone Nycomed or to any excipient in the drug

Systemic mycoses

Vaccination with live viral or bacterial vaccines is contraindicated during immunosuppressive therapy with corticosteroids (an insufficient immune response may allow the live attenuated vaccine to cause an infectious disease)

With long-term therapy:

Duodenal ulcers

Stomach ulcers

Severe forms of osteoporosis

Severe myopathy (excluding myasthenia gravis of pregnancy)

Psychiatric history

Acute viral infections (herpes zoster, herpes simplex, chicken pox)

Chronic active hepatitis (with Hbs Ag-positive reaction)

Glaucoma

Polio

Lymphadenitis after BCG vaccination

Pre- and post-vaccination period (8 weeks before and 2 weeks after vaccination)

Drug interactions

The corticoid effect is weakened by the use of CYP3A4 inducers such as rifampicin, phenytoin, primidone, barbiturates, carbamazepine and aminoglutethimide.
The corticoid effect is enhanced by the use of substances that block CYP3A4: (ketoconazole, ritonavir), erythromycin, troleandromycin.

Organs of the gastrointestinal tract and metabolism

Hypoglycemic drugs

Prednisolone Nycomed interferes with the effect of hypoglycemic drugs by increasing blood sugar levels. Undesirable effect: increased risk of hyperglycemia.

Cardiovascular drugs

Diuretics that remove potassium (thiazides, furosemide, etc.)

Cardiac glycosides

Glycosidic effect due to potassium deficiency.

Angiotensin-converting enzyme (ACE) inhibitors

Increased risk of changes in blood count.

Antihypertensive

Reducing already low blood pressure.

Hormones for systemic use

Oral contraceptives

The level of prednisolone in the blood serum may increase due to its reduced metabolism. Undesirable effect: increased risk of developing side effects of corticosteroids. Excessive use of glucocorticoids may inhibit the growth-promoting effects of growth hormone.

Antimicrobial agents

Rifampicin

Increased metabolism of prednisolone. Undesirable effect: decreased effectiveness of prednisolone.

Amphotericin B

The effect of additional potassium loss in the kidneys. Undesirable effect: increased risk of hypokalemia and subsequent cardiac arrhythmias.

Fluoroquinolones

Undesirable effect: increased risk of tendon rupture.

Ketoconazole

Undesirable effect: may enhance the effects of prednisolone.

Products for the muscular, joint and skeletal system

Acetylsalicylic acid (ASA)

Acetylsalicylic acid is known to irritate the stomach, and prednisolone may mask this side effect. The mechanism is unknown. An increase in the clearance of acetylsalicylic acid due to the effects of prednisolone has been reported. There is an increased risk of developing gastrointestinal bleeding and ulcers, as well as a risk of reduced effectiveness of acetylsalicylic acid. Thus, the side effects of salicylates will appear when prednisolone is discontinued.

Nonsteroidal anti-inflammatory drugs (NSAIDs)

NSAIDs are irritating to the stomach, and prednisolone may mask these adverse effects. Undesirable effect: increased risk of gastrointestinal bleeding and ulceration.

Non-depolarizing muscle relaxants

Undesirable effect: prolonged muscle relaxation.

central nervous system

Barbiturates

Barbiturates stimulate liver enzymes and increase the metabolism of prednisolone. Undesirable effect: decreased effectiveness of prednisolone.

Phenytoin and fosphenytoin

Increased metabolism of prednisolone in the liver. Undesirable effect: decreased effectiveness of prednisolone.

Quetiapine

Corticosteroid-induced induction of P450-mediated quetiapine metabolism. Undesirable effect: decreased serum quetiapine levels.

To maintain control of symptoms of schizophrenia, an increase in the dose of quetiapine may be necessary.

Bupropion

Concomitant use with systemic glucocorticoids may increase the risk of seizures.

Immunosuppressants

Methotrexate

The mechanism is unknown. Strengthening the effect of prednisolone.

Cyclosporine

Prednisolone may increase plasma levels of cyclosporine.

Impact on laboratory testing and research

Skin reactions to allergy tests may be suppressed. The decrease in thyroid-stimulating hormone (TSH) increases.

Other agents

A reduced immune response makes it possible for infections caused by live vaccines to occur and may also lead to decreased effectiveness of vaccination.
There is an increased risk of developing generalized, potentially life-threatening infections when vaccinated with live vaccines.

The metabolism of glucocorticoids may be accelerated and, therefore, their effectiveness may be reduced.

Laxatives and beta sympathomimetics

Increased potassium loss.

Chloroquine, hydroxychloroquine, mefloquine

Increased risk of myopathies, cardiomyopathies

Coumarin derivatives

Reduced effectiveness due to the action of prednisolone.

Theophylline

Undesirable effect: increased clearance during treatment with prednisolone.

Cyclophosphamide

Single doses of prednisolone can inhibit the activation of cyclophosphamide, but the level of activation increases after long-term use.

Thalidomide

May enhance the effect of prednisolone.

Praziquantel

Possible decrease in the concentration of praziquantel in the blood due to the use of corticosteroids.

Undesirable effect: intraocular pressure may increase when taken simultaneously with prednisolone.

Inhibition of corticosteroid metabolism by licorice. Undesirable effect: Increased risk of corticosteroid side effects.

special instructions

Patients with certain physical problems, such as fever, injury, or surgery, may require a temporary adjustment of the daily corticoid dosage during treatment.

The risk of tendon disease, tendonitis, or tendon rupture will be increased when fluoroquinolones and corticosteroids are used concomitantly

Long-term use of the drug should be accompanied by an examination by an ophthalmologist every three months.

Long-term use may be associated with rapid progression of Kaposi's sarcoma

With the exception of replacement therapy, corticosteroids have a palliative rather than curative effect due to their anti-inflammatory and immunosuppressive properties. Long-term use, depending on the dose and duration of treatment, is associated with an increased incidence of undesirable effects. Patients receiving long-term systemic corticosteroid therapy should be monitored for hypothalamic-pituitary-adrenal (HPA) axis suppression (adrenal insufficiency), Cushing's syndrome, hyperglycemia, and glycosuria.

After long-term therapy with corticosteroids, treatment should be discontinued gradually to prevent “withdrawal syndrome”. Adrenocortical insufficiency may persist for months after corticosteroid treatment is stopped, and replacement therapy may be required during periods of stress (surgery, illness). The risk of adrenal insufficiency may be reduced by giving the drug every other day instead of daily doses.

Due to the anti-inflammatory and immunosuppressive effects of corticosteroids, their use in doses higher than those required for replacement therapy increases susceptibility to infection, leads to aggravation of existing infectious diseases and activation of latent infections. The anti-inflammatory effect can lead to masking of symptoms until the infectious disease reaches an advanced stage. If new infections occur during treatment, the fact must be taken into account that it will be impossible to localize such an infection

In patients with latent tuberculosis (TB), corticosteroid therapy may increase the risk of developing TB. Such patients should be closely monitored for reactivation of TB and, if long-term corticosteroid treatment is required, anti-TB chemotherapy may be indicated. The use of corticosteroids in patients with active tuberculosis should be limited to cases such as exacerbation or dissemination of TB if their use to treat the disease is planned in conjunction with appropriate anti-tuberculosis therapy

Systemic corticosteroid therapy may increase the risk of severe or fatal infections in persons exposed to viral diseases such as chickenpox or measles (patients should be warned to avoid this risk and to seek prompt medical attention if it occurs). Corticosteroids may promote the development of bacterial and fungal infections (Candida infections). Corticoids may reactivate latent amoebic infections, so it is important to exclude them before starting corticoid therapy

Prednisolone enhances gluconeogenesis. Approximately 20% of patients treated with high doses of steroids develop benign "steroid diabetes" with low insulin sensitivity and a low renal threshold for glucose. The condition is reversible when therapy is discontinued. In established diabetes mellitus, treatment with corticosteroids usually leads to imbalance, which can be compensated by adjusting the insulin dose

Long-term treatment with prednisolone affects calcium and phosphate metabolism and increases the risk of osteoporosis. Prednisolone helps reduce calcium and phosphate levels, which affects vitamin D levels, thereby causing a dose-dependent decrease in serum osteocalcin (a bone matrix protein that correlates with bone formation)

Treatment with prednisone for several weeks puts children at risk of developing growth retardation due to decreased secretion of growth hormone and decreased peripheral sensitivity to this hormone.

Corticosteroids may cause psychiatric disturbances, including euphoria, insomnia, mood swings, personality changes, depression and psychotic tendencies

Long-term use of systemic corticosteroids may cause posterior subcapsular cataracts and glaucoma (due to increased intraocular pressure), as well as an increased risk of eye infections. Ophthalmological examination and treatment are mandatory in cases of glaucoma, ulcers and corneal trauma. Patients with herpes infection have an increased risk of developing corneal damage because prednisolone may mask the infection.

Corticosteroids should be used with caution in the following conditions:

Gastrointestinal diseases such as ulcerative colitis and diverticulitis due to the possibility of colonic perforation, colonic abscess or other pyogenic infections, colonic obstruction, severe fistulas and sinus tracts, fresh intestinal anastomoses and latent peptic ulcers. The anti-inflammatory properties of glucocorticoids may mask signs of gastrointestinal perforations and thus lead to delayed diagnosis and, consequently, potentially fatal outcomes.

High blood pressure or congestive cardiovascular disease (due to the mineralocorticoid effect of prednisolone, which can lead to fluid and salt retention)

Osteoporosis (because corticosteroids may worsen symptoms of osteoporosis)

Known and suspected infections

Known lymphatic tumors, as there have been reports of acute tumor lysis syndrome following administration of glucocorticoids

Heart or renal failure: concomitant effective therapy for the underlying disease and ongoing constant monitoring

Liver disease

Hypothyroidism

Myasthenia gravis, which may lead to increased myopathy

Cerebral malaria (coma may be prolonged, incidence of pneumonia and gastrointestinal bleeding may increase)

Latent epilepsy

Hyperparathyroidism (as prednisone may promote disease)

Treatment of patients with acetylsalicylic acid or non-steroidal anti-inflammatory drugs (due to increased risk of ulcer formation)

Diuretics that remove potassium.

In patients prescribed corticoids, the diet should be high in potassium, protein, and vitamins, but low in fat, carbohydrates, and salt.

In elderly patients, especially during long-term therapy, side effects such as osteoporosis and tendon diseases should be monitored. If possible, circadian or intermittent treatment is recommended for children during the growing period.

Patients with rare hereditary problems of galactose intolerance, Lapp-lactase deficiency or glucose-galactose malabsorption should not take this medicine.

Pregnancy and lactation

Prednisolone crosses the placenta. Animal studies have shown an increase in side effects depending on the dose (cleft palate, effects on growth and brain development). However, overall, these studies suggest a low risk to the fetus when prednisolone is used during pregnancy. But prednisolone therapy during pregnancy should be carried out only after a careful assessment of the benefits and risks to the fetus. If glucocorticoids are used late in pregnancy, there is a theoretical risk of fetal adrenal suppression, which may require a gradual reduction in the dose of replacement therapy in the newborn.
The amount of prednisolone excreted into breast milk is estimated to be 0.1% of the dose received by the mother. The dose received by the child can be minimized by avoiding breastfeeding for 3 to 4 hours after the mother receives a dose of prednisolone. Children of mothers taking daily doses of 40 mg or more should be monitored for signs of adrenal suppression.

Prednisolone is a rather complex synthetic drug, the use of which helps in the treatment of various diseases. At the same time, despite its effectiveness, its use can cause serious disorders in the body, and it has many contraindications, so before starting therapy, you must carefully familiarize yourself with its characteristics.

Composition of the drug and its dosage form

The pharmaceutical industry produces several dosage forms of this drug:

Tablets containing 0.001; 0.005; 0.02 or 0.05 g. prednisone.
Suspension and solution for intramuscular and intra-articular injections – ampoules of 25 and 30 mg.
Ophthalmic suspension 0.5%.
Prednisolone ointment for external use in tubes 0.5%.

Additional substances included in the tablets: lactose, potato starch, gelatin, magnesium stearate.

Composition of one tube (10 g) of ointment:

prednisolone – 0.05 g;
glycerol;
paraffin;
stearic acid;
Cremophor A6 and A25;
methyl parahydroxybenzoate;
propyl parahydroxybenzoate;
purified water.

The shelf life of prednisolone is 3 years from the date of manufacture. An open drug for the treatment of ophthalmic diseases should be stored no longer than 4 months, otherwise its effectiveness is significantly reduced.

Prednisolone is a steroid drug obtained by synthesizing cortisone. It is an analogue of those hormones that are produced in the body by the adrenal cortex and belongs to the spectrum of synthetic glucocorticosteroids (GCS).

Biologically active hormones of GCS are used as anti-inflammatory, desensitizing and anti-shock agents. In addition, the drug is considered an immunosuppressant and a good one. Antiallergic agent. This versatile effect of prednisolone is explained by the fact that it affects the level of carbohydrates in the human body and is able to regulate protein-fat metabolism.

With prolonged use of this drug, the activity of the pituitary gland is suppressed. It has amazing properties to reduce the growth of lymphatic tissue, and therefore is able to suppress the proliferation of connective tissue and tumor cells. In addition to all these properties, Prednisolone enhances the protective properties of the liver.

By reducing the secretion of allergy mediators and reducing cellular sensitivity to them, the drug has an antiallergic effect.

The drug Prednisolone contained in the ointment has a good anti-inflammatory, antiallergic and antipruritic effect, and prevents the formation of exudate (effusion).

The anti-inflammatory effect of the drop solution is due to a decrease in capillary permeability and strengthening of cellular components and membranes.

The effect of Prednisolone tablets begins 80–90 minutes after administration and is effective for 18–36 hours. The maximum concentration of the substance in the blood is achieved 8–10 minutes after intravenous administration, and 1 hour after intramuscular administration. The duration of the local effect is about 2–3 hours. After this, it partially decomposes and is excreted in urine and feces.

Scope of application of Prednisolone

Prednisolone tablets are usually prescribed not only for chronic diseases, but also for infectious-inflammatory, allergic, and autoimmune processes:

alveolitis, pulmonary fibrosis, sarcoidosis II–III degrees, tuberculosis, bronchial asthma.
polyarthritis, Still's syndrome, rheumatic fever, acute rheumatic carditis.
In pediatrics used as a means to combat laryngitis, laryngotracheitis, and severe forms of bronchial asthma.
- allergic rhinitis, Quincke's edema.
In transplantology used to suppress transplant rejection.
for medicines and food products.
Prednisolone in ampoules is used to provide emergency care for burns and infectious-toxic shock.
– various types of dermatitis, psoriasis, eczema, Lyell's syndrome, Stevens-Johnson syndrome.
Blood diseases– autoimmune anemia, lupus erythematosus, leukemia, lymphogranulomatosis, congenital anemia.
In ophthalmology– inflammatory eye diseases, optic neuritis, allergic forms of conjunctivitis.
Prednisolone tablets are used in the treatment of adrenal insufficiency and cancer.
For some infectious diseases– tuberculous pericarditis, Pneumocystis pneumonia.
– ulcerative colitis, Crohn’s disease, local enteritis.

Use as an aid

Taking Prednisolone increases blood glucose levels, which is why it has become popular in sports. Runners and cyclists use it to increase endurance, which has been the cause of numerous doping scandals. In strength sports, the drug is a tool for combating pain and swelling after injuries.

Prednisolone is taken for rheumatism

In cases where the patient requires urgent assistance (with a sharp drop in blood pressure or in a state of shock), it is advisable to use intravenous injections of prednisolone.

Prednisolone-based ointment is used for skin diseases of non-microbial origin: eczema, itching, various skin inflammations, alopecia.

In the treatment of rheumatism, Prednisolone prevents the development of heart defects.

Taking Prednisolone

Using tablets or ampoules without the consent of your doctor can have a number of negative consequences. Therefore, you must first undergo all the necessary examinations and follow the doctor’s instructions.

In medical practice, Prednisolone is most often prescribed depending on the patient's condition. In case of acute illness, as a rule, the dose is 4-6 tablets per day, with a larger dose to be taken in the morning during or after meals. It is advisable to take the tablets with plenty of water.

Prednisolone instructions

When the condition stabilizes a little and the therapeutic effect is noticeable, the amount of the drug is reduced to 1-2 tablets (5-10 mg).

Particular care should be taken to monitor the reaction to Prednisolone in those patients who have ever suffered from psychosis.

For external use, the ointment is applied to the affected areas of the skin in a thin layer 1-3 times a day. At the same time, it is not advisable to cover the treated areas with anything, so as not to create a greenhouse effect. For skin diseases, the duration of therapy is usually no longer than 1–2 weeks, depending on the severity of the condition.

It is not recommended to use the medicine for longer than 14 days without first consulting a doctor. Eye drops must be instilled into the conjunctival sac (the space located between the eyeball and the lower and upper eyelids) 1-2 drops three times a day. The duration of treatment of ophthalmological diseases with Prednisolone should not exceed 14 days. Before instilling the medicine, you need to remove your contact lenses, and only after 15 minutes can they be put on again.

Due to the excessive tearing that Prednisolone leads to, it is not recommended to drive immediately after instillation.

Features of taking Prednisolone for children

The children's dosage of the drug is much less. For children who are already 3 years old, the daily dose is 1–2 mg per 1 kg of body weight. This amount should be divided into 3-4 doses. As maintenance therapy, the amount of the drug should not exceed 0.3-0.6 mg per 1 kg per day. As soon as a positive effect is noticeable, the dose is gradually reduced. It is not recommended to suddenly stop taking the drug. This is a very important rule that should always be followed when treating with Prednisolone.

In some cases, the dose of Prednisolone may be temporarily increased. Such cases include:

nervous stress;
surgical intervention;
infection;
allergic reaction;
injury.

Doctors say that it would be more advisable to take the drug in the morning, or more precisely, from 6 to 8 o’clock. This recommendation is explained by the fact that hormones in the adrenal cortex obey a peculiar rhythm and are released at a strictly defined time. Taking Prednisolone tablets will provide more benefits if taken with this regimen in mind. Therefore, you need to create a schedule for taking the medication in such a way that the amount of the drug entering the body gradually decreases in the evening.

If Prednisolone is used to treat infectious inflammation, it must be combined with antibiotics. The duration of treatment with ointment for children over one year of age should not exceed 3–7 days.

The volume of Prednisolone injection may vary depending on the disease and the area where the drug is administered:

small joints – 10 mg;
medium – 25 mg;
large – 50 mg.

After monitoring the patient's condition, doctors may sometimes decide to increase the dose. After administration, the patient must move the joint so that the drug spreads throughout the body faster.

When mixing hormonal drugs and alcohol, a hypertensive crisis can occur.

In what cases should the medicine not be used?

Like any other drug, Prednisolone has many contraindications. First of all, the restriction applies to women expecting a child. But even during lactation, this drug can negatively affect the mother’s condition and the quality of milk. Another important contraindication is children under one year of age and the vaccination period.

Doctors warn that treating diaper dermatitis with prednisolone in infancy is extremely undesirable. In rare cases, Prednisolone can cause individual intolerance.

Disorders of arachidonic acid metabolism are a serious reason to refuse treatment with this drug.

For both adults and children, there is a long list of diseases for which taking Prednisolone is harmful and can lead to various complications:

Diabetes mellitus (sometimes treatment is acceptable, but under strict supervision).
Circulatory failure.
Skin diseases caused by bacteria and viruses.
Acute purulent processes in the eye area.
Increased ophthalmotonus.
Skin tumors.
Active tuberculosis.
Polio.

It should be used with caution in acute tenosynovitis.

Negative effects on the body

One of the most common side effects of this drug is obesity, but only after a long course of treatment. For women, taking Prednisolone can result in menstrual irregularities.

The ability to increase blood glucose levels can lead to diabetes. When taking this drug, immunity is significantly reduced. This is expressed in a decrease in the body’s immunological response, the so-called immunosuppressive effect. Therefore, during and after treatment, it would be useful to take care to restore the body’s defenses.

After using eye drops, patients notice the following symptoms:

A brief burning sensation in the eyes immediately after instillation.
Increased tear production.
Risk of developing cataracts (with long-term use).

All patients must take into account that long-term use of Prednisolone leads to increased blood clotting, problems in the digestive tract and mental disorders.

Prednisolone analogues

The only analogue of Prednisolone is Prednisolone hemisuccinate. In pharmacies you can find many drugs that are similar in composition, but differ in name:

Antizolon.
Delta Cortef.
Gostacortin N.
Cordex.
Dihydrocortisol.
Metacortandrolone.
Prenolon.
Sgerolon.
Ultracorten N.

Even after reading the instructions, you should not rely on your own knowledge and take this drug yourself. Due to the fact that its properties are quite extensive, the consequences of uncontrolled treatment can lead to dire consequences.

One of the pharmacy names that is in great demand is “Prednisolone”. The use of tablets is possible only under the supervision of a doctor, since there is a high probability of adverse reactions if the conditions of prescription are not followed. The medication is one of the antiallergic medications. In addition to the tablet form, other release options are also available for sale - a substance for injection, products for external use (ointment, gel). Let's look at what the effectiveness of the drug Prednisolone is based on and how to use it correctly.

What is inside?

As can be seen from the instructions for use, Prednisolone tablets are based on the component of the same name, present in one serving in the amount of half a gram. To enhance the effectiveness of the product and simplify its use, the manufacturer adds other ingredients, listing everything used in the instructions. In particular, glycerin, petroleum jelly, water, emulsifier, and special acids were used in the production. Persons suffering from allergic reactions to substances used in medicine should read this list especially carefully. If Prednisolone is prescribed by a doctor, you should first inform the doctor about all possible negative responses of the body in order to prevent an unpleasant outcome of treatment.

Why use it?

As follows from the instructions for use, “Prednisolone” (reviews confirm the effectiveness of the drug) is used to relieve inflammatory processes and allergic reactions of the body. The product helps cope with itching and has an anti-exudative effect. Soon after the penetration of the active compound into the human body, the following is observed: the formation and release of inflammatory mediators is controlled, inhibited. Prednisolone affects kinin, histamine, and controls the activity of lysosomal enzyme compounds. Under its influence, cells cannot freely move to the inflammatory focus. Prednisolone reduces the permeability of vascular walls in the area of localization of the inflammatory process and inhibits vasodilation.

Exudation when using Prednisolone ointment (as well as tablets or ampoules) becomes less active. The process is due to the vasoconstrictor effect. The main compound of the drug is capable of inhibiting macrophages, cytokines, and reducing the activity of target cells. In this way, it is possible to control all elements of the body that take part in the development of contact dermatitis caused by an allergic reaction. Under the influence of Prednisolone, target cells are protected from the effects of macrophages and T-lymphocytes that have undergone sensitization.

What's going on inside?

If you follow the instructions for use, Prednisolone is well tolerated by the body, as medical studies show. Shortly after contact with tissue, adsorption occurs and the active compound quickly enters the circulatory system. This applies to all forms of drug release. Up to 90% of the total volume quickly enters into a binding reaction with plasma proteins. Prednisolone is able to contact albumin and transcortin. Biological transformation processes - oxidation, localization - liver. Metabolic products are soon excreted in urine and bile. A certain percentage leaves the body unchanged.

As medical studies have shown, the use of Prednisolone (injections, tablets, ointments) has strict restrictions for women in an “interesting” position, since the drug crosses the placenta and can affect the fetus. A biochemical study of breast milk also showed a small percentage of the active compound, which imposes restrictions on the possibility of natural feeding of the child while undergoing a therapeutic course.

When to use?

Reviews on the use of Prednisolone confirm that the drug is effective against a wide variety of allergic diseases. It can be used to relieve the inflammatory process. The product was developed as an element of complex therapy and is suitable for treating exclusively cases not caused by microbial infection. Prednisolone can be used against urticaria, some forms of lichen and dermatitis, eczema, and lupus. The product is effective for a number of causes of hair loss. It is better to coordinate the specifics of use with the doctor, who first takes tests to determine the nature of the problem.

Sometimes you can't

The instructions for use of Prednisolone contain a number of restrictions on the use of the drug. In particular, the product is not intended for the treatment of persons suffering from hypersensitivity to the active ingredient or any other compound used in the manufacturing process. Prednisolone should not be used (externally or internally) if skin lesions are caused by a fungal infection or microbial infection or virus. The medication is not intended for the treatment of ulcers, is not suitable for open wounds, and is dangerous for persons suffering from trophic ulcers. Prednisolone should not be used if the patient’s allergic response is provoked by a vaccine that causes a reaction on the skin.

The instructions for use of Prednisolone contain restrictions on the consumption of the drug by persons diagnosed with syphilis and tuberculosis. The medication is not intended for pregnant and lactating women, children one year of age and younger. You should not use the drug if skin tumors are detected or acne is bothering you - the active substance can provoke an exacerbation of the disease. In some cases, for these conditions, the doctor may decide on the need to use Prednisolone. In this case, the patient will have to be warned about all the risks associated with such therapy, as well as to outline the course of action in the event of adverse reactions.

Special case: we treat children

The use of Prednisolone by children has a number of specific features. If the baby is one year old or younger, the medication is strictly prohibited. For persons over one year of age, the product can be used, but in limited quantities and under the supervision of a specialist. It is necessary to prevent situations that could provoke a greater resorption of the absorption of the active compound. It is not allowed to use bandages for fixation, warming, or occlusion. When using it, take into account that the skin folds of babies can have a similar effect, as diapers and diapers can have this effect. Under the influence of these factors, systemic resorption becomes higher.

Another feature of the use of Prednisolone in the treatment of young patients is associated with different ratios of mass and area of the skin. This leads to an increased likelihood of suppressing the functioning of the adrenal glands, hypothalamus, and pituitary gland. Consequently, the risk of Cushing's syndrome increases. Long-term therapy can cause developmental and growth disorders. To prevent negative effects, it is recommended to use Prednisolone in the lowest possible dosage and under constant supervision of a specialist.

Features of therapy

As follows from the instructions for use, Prednisolone is intended for a two-week course or shorter use. It is strictly not recommended to use the product for longer than 14 days. Certain limitations are associated with the localization of the reaction to eliminate which the drug is used. If an external form is chosen (ointment, gel), it should not be applied near the eyes, since such a practice can provoke cataracts and glaucoma. If therapy involves treating a one-year-old (or older child), if the drug must be used externally and applied to the face, to an area covered with a special bandage, the therapeutic course will have to be shortened. To avoid a negative response from the body, the medication should be used strictly under medical supervision.

The instructions for use of Prednisolone warn that when treating young patients, there is a higher likelihood of suppressing the functionality of the adrenal glands. There is a possibility of decreased excretion of the hormonal compound. If there is a need for a long therapeutic course, it is important to monitor the patient’s weight, changes in height, and plasma cortisol concentrations.

Accuracy doesn't hurt

As follows from the instructions for use, “Prednisolone” in the form of an ointment or gel does not affect a person’s ability to concentrate attention and does not affect the speed of reaction. While undergoing this therapeutic course, you can engage in various activities that involve potential danger, including operating machinery. The speed of mental and motor reactions during the course does not suffer if the product is used in accordance with the recommendations of the doctor or manufacturer.

How to use externally

Instructions for use of Prednisolone ointment indicate the need to apply a thin layer of the drug to the affected skin areas. Frequency of application - up to three times daily. The duration of the therapeutic course is determined by the specific characteristics of the disease, the body’s response, and the degree of effectiveness of the chosen treatment method. Typically the course takes from six days to two weeks. In some cases, the doctor may recommend using the ointment as a follow-up treatment for a longer period of time, reducing the frequency of use to once a day.

A special approach requires treatment of such areas of the body where the skin is of increased density. This applies to the feet, elbows, and palms. The manufacturer indicates in the rules that the use of Prednisolone may be more frequent. A similar approach requires treatment of such areas of the skin from where the drug is quickly erased. To increase the effectiveness of applying the active component, you can apply an occlusive dressing. This is allowed only for limited inflammatory, allergic foci and only in agreement with the doctor, if the drug is well tolerated.

Unpleasant effects: what to prepare for?

The use of Prednisolone in case of intolerance to any of the components is associated with a high probability of swelling and skin itching in the areas where the medication is used. Possible hyperemia and acne. Sometimes the skin becomes dry and irritated. In rare cases, this effect occurs even with normal tolerability of the components. Prolonged use may cause infectious secondary skin lesions. Prednisolone can provoke atrophic processes and hypertrichosis. To prevent possible negative outcomes, Prednisolone should be used simultaneously with antimicrobial compounds and drugs to eliminate fungal infections.

A long course of treatment may cause increased cortisolism. This is especially true if the use of Prednisolone is necessary over fairly large areas. This effect is due to the resorptive ability of the active compound. If such an adverse reaction is recorded, immediate discontinuation is required. In case of any negative reaction of the body to Prednisolone, it is necessary to consult a doctor as soon as possible. A particularly dangerous situation arises if the answers that arise are not indicated as possible in the instructions for the product. It is necessary to inform the specialist about all unpleasant experiences associated with applying the ointment or gel.

Too much!

Regardless of the chosen form of use, Prednisolone can be overdosed. This can be suspected by the Itsenko-Cushing effect. Possible inhibition of the activity of the pituitary gland, hypothalamus, and adrenal glands. To exhaust the symptoms, you should gradually stop using the medication under the supervision of a doctor.

If an overdose is detected simultaneously with a decrease in the amount used, symptomatic therapy is also required. Sometimes it is additionally necessary to adjust the electrolyte balance to bring the body systems back to normal.

Is it possible to do it together?

The use of Prednisolone (ampoules, tablets, ointments) in combination with other drugs may cause an increase in the effect of any of the compounds or lead to the opposite effect. In particular, if the patient uses anticoagulants, their water activity under the influence of the main substance in question becomes higher, but when combined with salicylates, the risk of bleeding increases. When taking diuretics and Prednisolone, you may encounter problems with electrolyte balance, and cardiac glycosides become more toxic.

If Prednisolone injections (instructions for use must be strictly followed!) are recommended for people suffering from diabetes, one must remember that the hypoglycemic effectiveness of medications used by this group of patients is inhibited. If the patient is treated with rifampicin, its antimicrobial effect is also weakened. Prednisolone should not be used with antacids.

Effective and efficient

As can be seen from the instructions for use of Prednisolone ointment (reviews confirm the effectiveness of this product), the drug is able to combat shock conditions and eliminate toxicosis. The drug belongs to the category of immunosuppressive. Use in high dosages inhibits collagen synthesis. Protein catabolism occurring in muscle fibers becomes faster. At the same time, protein production by the liver is activated.

The anti-shock effect, as explained in the instructions for use of Prednisolone (the medication for injection is presented in ampoules on pharmacy shelves), is associated with the effect on the circulatory system, the activation of the response to compounds that can narrow the lumens. At the same time, receptor sensitivity to catecholamines is restored. The hypertensive effect of the compounds is enhanced. When Prednisolone enters the body, water and sodium retention is observed.

Features: How it works

As follows from the instructions for use, Prednisolone in ampoules is more suitable for adults than for treating children. This drug stimulates the liver processes of producing protein compounds, due to which the medication has an antitoxic effect on the patient. In liver cells, metabolites that are toxic to humans are more quickly inactivated, and xenobiotics are processed. Water cell membranes become more stable under the influence of the active compound Prednisolone. This also affects hepatocytes.

Liver cells under the influence of the drug more actively deposit glycogen. Protein metabolism affects glucose synthesis, and the growth of this component in the blood provokes the release of insulin. As follows from the instructions for use, Prednisolone (the drug is also suitable for children) does not allow fat cells to receive glucose, due to which lipolysis occurs more actively. Increased insulin production causes lipogenesis, which is the basis for fat accumulation. Under the influence of the active compound, calcium is absorbed through the intestinal tract with a less efficient process, but is quickly washed out of the bones, leaving the body through the kidneys.

Specific impact

The instructions for the use of Prednisolone in ampoules for children and adults (as well as another form of the drug) indicate that under the influence of the compound the excitability of brain tissue increases. This leads to a slight decrease in the threshold for the occurrence of a convulsive state. Drug therapy requires careful attention and constant monitoring of the patient's condition. This is especially true when treating young patients.

Medical studies have shown that the use of Prednisolone leads to an excess of hydrochloric acid in the stomach. The drug activates the processes of pepsin production. If a patient is sick with a peptic ulcer, this leads to a worsening of the condition, but healthy people are at risk of developing such a pathology.

Ampoules: when to use?

In this format, Prednisolone is intended for the treatment of systemic pathologies affecting muscle tissue. The drug is effective in some forms of periarthritis, lupus, and helps with ankylosing spondylitis. Prednisolone is prescribed as part of the therapeutic course of scleroderma and dermatomyositis. The drug can be used against blood diseases, including purpura, leukemia, anemia and some other pathologies. Injections will help against skin diseases: eczema, pemphigus, dermatitis, psoriasis. Prednisolone is prescribed if necessary to treat adrenogenital disorders.

In Addison's crisis, Prednisolone is taken as part of a course of replacement treatment. It is sometimes used in conditions where emergency care is required. This is typical for Crohn's disease, colitis, and a shock situation provoked by various factors - surgery, burns, trauma. Prednisolone is recommended for use in cases of anaphylactic response or severe allergic reaction. The product will help with hypoglycemia.

Additional uses

Sometimes doctors prescribe Prednisolone as an injection into the joint. This approach helps eliminate arthritis and arthrosis. The medication can be used in the complex treatment of chronic polyarthritis or osteoarthritis that affects large articular systems.

Introduction Features

You cannot use one syringe for the simultaneous administration of Prednisolone and other medicinal compounds. It is not allowed to use an infusion system to deliver this drug into the body simultaneously with other substances. The drug can be injected into a vein, muscle tissue or joints. The doctor determines the dosage by assessing the severity of the patient’s condition. For adult patients, it is recommended to use 4-60 mg on average per day.

Prednisolone injections for children should be given into the gluteal muscle, and the medication should be injected as deeply as possible. Constant medical supervision is required; at home use in this form is not harmful. For patient ages from 6 to 12 years, the dosage per day is up to 25 mg; for older children, the amount can be doubled. The duration of the course and the number of injections are determined by the doctor, focusing on the individual reactions of the body.

Cases and rules

If Addison's disease is detected, Prednisolone should be used per day in a dosage of 4-60 mg (calculated for an adult patient). If ulcerative colitis is diagnosed, the disease is nonspecific, the form is severe, Prednisolone is used daily in an amount of 8-12 ml. Duration of treatment is up to six days. Crohn's disease is treated with Prednisolone in a dosage of 10-13 ml daily for seven days.

Emergency conditions require slow injection of the active compound into the patient's vein. The duration of the procedure is about three minutes. Drip administration is allowed. Dosage - from 30 mg to twice the volume. If administering the drug into a vein is difficult, the drug is injected into the muscle tissue as deeply as possible. It must be taken into account that the effect will appear more slowly. If the situation requires it, Prednisolone is reused half an hour after the initial administration in an amount from 30 mg to twice the dose.

Additional features

In rare situations, the doctor may prescribe an increased dosage of the medication if he sees obvious indications for this. This decision must be made by analyzing the individual characteristics of the course of the disease. It is strictly forbidden to increase the dose on your own due to the high likelihood of side effects.

If the drug is used to treat joints, 30 mg is required for an adult patient when treating the area of a large joint. For medium-sized joints, 10-25 mg is enough, for small joints - 5-10 mg. Injections are given every three days, the duration of the therapeutic program is three weeks.

Restrictions on use

Prednisolone is not intended for the treatment of persons who have recently recovered from a viral pathology, fungal infection or bacterial infection. The drug should not be used if such a disease currently exists. This restriction applies to some types and forms of herpes, smallpox and measles, and mycosis in systemic form. The drug is dangerous for persons who are suspected or definitely diagnosed with strongyloidiasis. “Prednisolone” is not used for amoebiasis, tuberculosis, not only in active form, but also in latent form.

Thank you

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

Due to the fact that prednisolone inhibits the functioning of the immune system, any scratch, even the smallest one, can take a very long time to heal, and can begin to break out. You may get sick more often from colds and viruses, as well as any other contagious diseases.

With long-term use in large dosages, disruption of the central nervous system, resulting in mental disorders, is possible.

Use prednisolone only as prescribed by your doctor and under his constant supervision. Then the number of side effects will be minimized.

Before use, you should consult a specialist.

Reviews

Hello! I was prescribed prednisolone as an antitumor drug for lung cancer. I took 100 tablets per month according to the plan. As a result, I planted kidneys, and my urine readings just went through the roof and my temperature did not subside. I've lost a lot of weight. The drug did nothing but harm me and in addition the muscle pain increased. Believe it or not, my only sin is prednisolone.

I had severe eczema. My hands became covered with blisters, they burst, sores and terrible itching appeared. In leather At the dispensary they made systems with prednisone. Everything went away immediately. But literally on the 4th day everything returned with renewed vigor. I couldn't do anything. My hands were cracking and itching. The skin was covered with scabs. Lasted 2 months. I went to the skin clinic again. I accidentally came across a consultation with a professor. He prescribed a course of treatment. First, 5 systems, then take prednisolone 15 mg a month. Then you need to reduce it according to the system. But the attending physician did not tell me about this system. Apparently she didn’t really know. Therefore, I reduce it myself, read it in the institute. I’m taking half a tablet now, but suddenly I started having abdominal pain. Pancreatitis. Either from prednisation, or for another reason. After 1.5 months, eczema reappeared, but in a mild form. The treatment had no effect on weight.

Crohn's disease is treated with the drug Budenofalk

I read the instructions and was amazed. It turns out that this is a “balm” for everything serious and not so serious. diseases. From observation I see that our “killers in white coats” willingly use it. We treated it, achieved a short-term effect and hell. How the patient will recover from this poison is not of particular concern to them.

Information on personal use of prednisolone for polymyalgia rheumatica. Polymyalgia started after getting a flu shot. Wild pains throughout the body, especially in the morning. I was unable to cut off a piece of bread for breakfast, the muscles in my arms were so sore. The doctor prescribed 15 mg. prednisone for a month. Subsequently there was a decrease of 1 mg. within every two weeks. I regularly take vitamin D-3, which helps maintain calcium in the body, and always take calcium in the amount of 1000 units. daily. It is very good to use flaxseed oil with cottage cheese. Hormonal medications should not be stopped abruptly, only by a gradual reduction to 1 mg. Thank God I ended up with a smart, knowledgeable doctor. Look for knowledgeable doctors, read literature about your disease.

My bones began to hurt very badly after prednisone, I started taking calcide and magnesium. I would like to ask if anyone can suggest a good remedy. And I got rid of stomach pain. Every morning and evening, on an empty stomach, I drank a glass of hot milk (boiled). Added a spoonful of honey. A month later the pain disappeared.

Prednisolone is another slow death. If possible, don't take it. Look for alternative treatment options. Doctors don’t care, they count on quick relief of symptoms... I experienced all its delights myself. I almost died from the pressure... I could have gone blind... the weight is gained very quickly... but losing weight is very difficult... osteoporosis and diabetes are developing... it’s scary. I have membranoproliferative glomerulonephritis. Eight months on these pills. And now I’m recovering from them. There is an alternative... try, look... now only Walz, Arifon and Rosecard. Fish oil... I regret that I found a normal doctor too late. Don't take prednisolone, this is not life, this is only torment....

First of all, look for good doctors! Look for information on medical forums. Read and study your disease and don't be afraid to talk to your doctor! Your health is in your hands.

I want to tell you guys about how I started taking prednisolone (only I was prescribed a slightly different one, Medrol)
but it’s like the same prednisolone “In general, I always had a small hemoglobin, every time after eating, everything immediately went down the drain, also with blood... In general, this lasted for 9 years, now I’m 16. Doctors could not make a diagnosis until after I turned 15. At the age of 15, I went to an adult doctor, he looked, felt my stomach, everything, knots... He said that most likely I had Crohn’s disease. Of course, I was in shock because I didn’t know that I had it illness. He prescribed the drug "Salofalk" in this dose... 4000 ml (and should have taken 1500 ml) I started drinking them for about 7 days, maybe less. Somehow on the 8th day I felt very bad! Vomiting, toilet 5 -6 times a day, just water... I couldn’t even walk anymore, I lay in this state for about 50 days, on the 51st I started bleeding, only blood from the intestines (large stomach). In general, I ended up in a regional hospital, in intensive care, hemoglobin 33 , weight 39 kg, basically a corpse! I spent 1 day in intensive care, they pumped out plasma, blood transfusions, saved me, thank God. I started taking Prednisolone (Medrol). In the morning, 1 tablet (32 mg) and in the afternoon 1 (16 mg ) Total 48 mg. I started reducing the dose, I’ve been reducing the dose for 4 months now, now I take 22 mg. I take 2 mg off every Friday, what I want to say is that there are side effects, pressure, headache, my stomach has grown huge, my face is also big, like swollen. ..Now my face has become a little smaller, since I’m reducing the dose! Tell me, who took it and stopped taking it, does all this go away, big face, pain in the head??

Gennady, did you have any side effects? The doctor prescribed it for your son

I have been taking prednisolone since 2011, the diagnosis is still unclear, main RA or polymyalgia rheumatica. For several months I took 3 tablets, then one at a time, and by December 2014 I very slowly came off it. At first everything was fine, but in June 2015 it became bad, I took it for 5 days at a time and it got better, but the therapist said that it was better not to take it. This therapist generally always prescribed many other expensive pills, just because he works for the pharmacy. And another therapist said that it’s okay if the courses depend on the pain. A well-known rheumatologist in the city said that it is not yet known what is better, a handful of painkillers or one tablet of prednisolone. Now my hands and arms began to completely numb and it became difficult to get up from a low start, I started taking one 5 mg dose again, after 2 days it became better, but still not quite good. In general, doctors interpret it differently, you have to figure it out on your own through trial and error. And don’t get corroded, that’s the most important thing. 200 grams per meal and you won’t gain weight. Drink more water, especially in the first half of the day.

During pregnancy, autoimmune thrombocytopenia develops, I take 12 tablets a day. Terrible pain in the stomach, absolute insomnia, I feel like the roof is going away, swelling of the face. I'm freaking out, I'll quit for now so that at least some of the side effects go away. Besides a drop in platelets, what else does this threaten me with? (without prednisone, platelets drop to 19 units

The first time I took prednisolone for urticaria. Now this drug is simply impossible to eliminate. And doctors prescribe it, and in a lethal dose, my usual allergy has developed into angioedema. All the side symptoms appear. And not mild ones. Is there no alternative replacement? I gained weight , everyone is in shock.

MOM has been taking prednisolone for 5 years (diagnosed with acquired autoimmune geolytic anemia). The disease does not go away, but while taking the medicine, severe osteomalacia and cataracts appeared, and she often suffocates. Tell me, how can I stop taking it?

They prescribed me prednisolone, I have breast cancer, my blood is bad, they didn’t give me taropia chemotherapy

I took prednisolone for a very long time for about 8 years, now I suddenly stopped taking it and began to feel very bad, all my bones hurt and I can’t sleep. Could this be due to abruptly stopping prednisone?

You have to be careful with this drug, it’s better not to take it at all, you’ll gain weight very very much, be careful

Hello, I’m 11 years old, I take prednisolone because I suffer from glomerulo-nephritis, my dose is 9 tablets in the morning and at 11:00 1 tablet (I’ve been taking it since October, I took it every day in the hospital) and every other day since November 7 (in the morning -9 and at 11:00- 6) During this time I gained 10 kg, that is, my weight was 59 kg (and in the hospital it was 50 kg), now I have started to lose weight, now my weight is 57 kg (height is 153 cm) Please tell me “Will I lose weight after stopping prednisolone? Cancellation will be July 22, 2013.”

Hello! I overate sweets, and a severe allergy began, I was covered in weeping sores for hours ((I went to the hospital, they first prescribed prednisone in injections, while I was injecting (3 days) everything healed quickly, but as soon as I stopped injecting everything came out again (((I went to the doctor again and prescribed prednisone in tablets(((I’m afraid it won’t help, it will also ruin the body((((And the body has not yet recovered after childbirth (1 year ago). Tell me if anyone has had something similar))

Hello. Prescribed prednisone in case of an acute allergic reaction. I haven't taken it before. I am allergic to birch and oak pollen. hazel After the first use, I realized that it was not weak. Sometimes I take it to calm down. Sometimes I mix it with alcohol. In general, I take it or in case of allergies, and once a week. As I understand it, it is better to leave it only as an emergency remedy. What are the dangers of prednisone addiction? I'm a guy, 21 years old.