Salbutamol - instructions for use and form of release, indications, composition, dosage and price. Aerosol for inhalation salbutamol Use in pregnancy

In the 60s of the last century, scientists developed a chemical compound that positively affects the smooth muscles of the upper respiratory tract, changes the level of potassium in the blood, and relaxes the muscles of the uterus during pregnancy. Its name is salbutamol. Today it is the main drug in the international classification, designed to relieve an attack of shortness of breath and relieve unpleasant symptoms in diseases of the upper respiratory tract.

Aerosol for inhalation Salbutamol

Indications for use

In medicine, Salbutamol is known as a drug that can prevent and stop bronchospasm. Eliminates the symptoms of suffocation in a short period of time. It is recommended to prescribe for the following diseases:

• bronchial asthma of any origin;
• Chronical bronchitis;
• chronic obstructive pulmonary disease;
• contraction of the uterus with the threat of premature birth.

Salbutamol is included in the list of drugs intended for emergency medical care.

Contraindications for admission

There are the following contraindications to taking the drug:

Cardiac ischemia

• individual intolerance to the components of the drug or hypersensitivity;
• the period of breastfeeding;
• as a bronchodilator is contraindicated in pregnant women;
• coronary heart disease, myocarditis, cardiac arrhythmias, tachyarrhythmia;
• glaucoma;
• children's age up to 2 years;
• epilepsy;
• renal and / or liver failure.

The drug should be used with extreme caution in arterial hypertension, hyperthyroidism.

Active ingredients

The active substance is Salbutamol, belongs to the group of beta-agonists. It dissolves well in water. Difficult to dissolve in ethanol, ether. Excipients - ethanol, hydrofluoroalkane.

Pharmacodynamics

Belongs to the group of bronchodilators. It affects special receptors that are localized in the bronchi and blood vessels. Can increase overall lung capacity. The effect of the use of Salbutamol persists for a long period of time (about 6 hours). Relaxes the uterus. Stops premature labor activity. Does not affect the level of blood pressure in the vessels. Causes expansion of some large arteries. When inhaled, 5 part of the substance is in the small bronchi, the remaining amount settles in the upper respiratory tract. Well absorbed from the gastrointestinal tract. The highest volume concentration in plasma is reached after 3 hours. Semi-removable within 7 hours. Able to cross the placenta.

Salbutamol is not a hormonal drug. The difference from drugs with hormones is that it does not relieve inflammation and does not treat asthmatic and bronchial coughs. It acts symptomatically, quickly relaxing the muscles of the bronchi.

Release form

The drug is available in the following forms:

Salbutamol tablets

1. Tablets. They have a film cover. Available in dosages of 2 and 4 mg of the active substance.
2. Syrup. 5 ml contains 2 mg salbutamol.
3. Spray can. 1 dose contains 0.1 mg of the active substance. Produced in special cylinders with dispensers.
4. Solution for inhalation and injection. 1 ml contains 1.25 mg salbutamol. Often packaged in ampoules of 2 ml.
5. Powder for inhalation. One dose contains 200 or 400 micrograms of the active substance. Issued in special discs. Powder of white color, has no smell.

Manufacturers of the drug: pharmaceutical companies Binnopharm, Teva, Altaivitamins. These brands have been producing medicines for many years and have proven themselves on the positive side.

Analogs are Salbuvent, Astalin, Ventolin, Ecovent, Aloprol. These drugs can completely replace Salbutamol. When choosing between the original drug and similar in composition, it is best to be guided by individual preferences and doctor's recommendations. As a rule, similar substitutes for Salbutamol have a high positive effect.

Aerosol Ventolin

Instructions for use

The dosage prescribed by the doctor depends on the sex, age, and condition of the patient's body. It is necessary to check the expiration date on the package, carefully study the annotation and observe the storage conditions. The method of application depends on the form of the drug. For young children, Salbutamol is prescribed on an individual basis.

At the age of 6 to 12 years, the volume of the prescribed agent should be no more than half the dose for an adult.

Tablets are taken orally with the threat of premature birth in the II and III trimesters of pregnancy. Salbutamol relaxes the smooth muscles of the uterus, but at the same time carries multiple organ risks for intrauterine development of the fetus. When appointing, this circumstance must be taken into account.

Syrup and tablets Salbutamol

A good effect is achieved when using syrup in childhood. The doctor prescribes the dosage for each child, it is dangerous to self-medicate. The regimen for taking Salbutamol in the form of a syrup is calculated depending on the year of birth, sex, age and weight of the patient.

The correct use of an aerosol involves a number of sequential actions:

1. Shake the bottle.
2. Exhale deeply, and, fixing the nozzle vertically, insert it into the oral cavity.
3. Make a push. At the same time, inhale deeply.
4. Hold your breath and remove the nozzle from your mouth.

The maximum positive effect can be achieved after 5 minutes. Apply no more than 8 times a day. If relief still does not come, it is permissible to make an additional injection. Further, the drug is not used for 4-6 hours. For children under 4 years of age, inhalation with a spray is carried out through a spacer - a small container with two valves, at one end of which there is a bell for breathing, and at the other - a hole for the inhaler.

To perform inhalation with a solution of Salbutamol, a nebulizer is used. The mechanism of action of this device is simple: it turns a solution or dissolved powder into an aerosol. At home, every adult can carry out such procedures on their own.

There are the following stages of inhalation through a nebulizer:

Inhalation through a nebulizer

1. Before inhalation, you need to check the serviceability of the device. Remove all nozzles, evaluate their degree of cleanliness. If necessary, wash in soapy water and dry with a towel.
2. Open the medicine vial. Place it in a special container.
3. Connect the container to the mask for inhalation.
4. Using a tube, connect the nebulizer compressor to the solution container.
5. Turn on the nebulizer button.
6. After the procedure, rinse and dry all parts of the device.

Do not mix Salbutamol with other drugs. Dilution with saline or distilled water is allowed. An increase in the dose of the drug, a change in the treatment regimen should be carried out under the supervision of the attending physician.

Salbutamol is popular among athletes as a bronchial dilator. They use the drug during marathon races and during long, exhausting workouts. But frequent use is addictive, so doctors do not recommend doing inhalations when playing sports for healthy people.

Interaction with alcohol

Alcohol releases additional portions of adrenaline into the blood. In this regard, its combination with Salbutamol leads to a sharp increase in blood pressure. And increased urination shortens the duration of the drug. You should refrain from drinking alcohol for 3-4 hours after using the drug.

Compatibility with other drugs

It is necessary to take into account the effect of Salbutamol on the pharmacology of other drugs with their simultaneous use. Only a doctor prescribes the drug, self-medication can lead to negative consequences.

Side effects

When used correctly, the drug does not cause negative reactions. The consequences of exceeding the dose are manifested in an increase in the level of general fatigue, the occurrence of urticaria.

In case of an overdose, the following clinical manifestations are possible:

Dizziness

• tremor in the limbs;
• pain in the temples;
• nausea, vomiting;
• urinary retention;
• increased sweating;
• a state of panic;
• tachycardia.

In the presence of the above symptoms, symptomatic treatment is carried out. In extremely rare cases, an overdose of Salbutamol leads to uncontrolled bronchospasm. This state is dangerous. If you do not provide assistance in time, a fatal outcome is possible.

Salbutamol is able to quickly and effectively cope with asthma attacks. Its use makes life easier for people suffering from respiratory diseases. However, you must strictly follow the instructions and adhere to the recommendations prescribed by your doctor.

Some facts about the product:

Instructions for use

Price in the online pharmacy site: from 114

Pharmacological properties

Salbutamol AB has a bronchodilator effect, has a tocolytic effect on the body. The essence of the effect is to relax the smooth muscles of the bronchi. Selective stimulation of beta-2-adrenergic receptors helps to relax muscle tissue and improve airway patency. It has a relieving effect on attacks of bronchial asthma, COPD, chronic bronchitis.

The therapeutic result is achieved within 5 minutes after taking the drug. It has a long action that lasts from 3 to 6 hours. Subject to the recommended dosage, it does not provoke the development of cardiovascular pathologies and an increase in blood pressure.

Some facts

The main ingredient of Salbutamol AB - the substance salbutamol - has a relaxing effect on the smooth muscles of the uterus, inhibits the activity of the myometrium, and prevents premature birth.

Composition and form of release

The drug is produced in the form of an aerosol for inhalation. The metal container with a spray cap is equipped with a metering valve. The inside of the can contains a white suspension for spraying. The composition of the suspension includes salbutamol sulfate as an active ingredient, ethanol, oleic acid, tetrafluoroethane were used as excipients.

The inhaler is placed in a cardboard box together with instructions for use and a spray cap.

Indications for use

The drug is used to treat bronchial asthma, as maintenance therapy and as a prophylactic to prevent relapse.

Among the indications are the treatment of diseases such as COPD, bronchospastic syndrome, chronic bronchitis.

Side effects

The most common adverse reactions occur from the central nervous system in the form of headaches, dizziness, anxiety, fatigue, drowsiness.

Violations of the functions of the respiratory organs are formed infrequently and manifest themselves in the form of cough, irritation, bronchospasm.

Infrequently, the use of the drug causes allergic swelling of the face and throat, rash. The response to the use of Salbutamol AB may be vomiting, nausea, arrhythmia, muscle cramps.

Contraindications

Particular care should be taken to treat patients with heart diseases such as heart failure, tachyarrhythmia, high blood pressure, as well as women during gestation and breastfeeding.

Method and features of application

The dosage of Salbutamol AB is determined by the doctor according to the state of health of each patient individually.

The standard dose for adults and children over 12 years of age is 1-2 inhalations to stop bronchospasm up to 4 times a day.

The maximum number of inhalations as long-term therapy is up to 12 per day.

For patients aged 2 to 12 years, 1-2 inhalations are used to stop an attack and up to 8 inhalations (800 mcg) per day during long-term maintenance treatment.

The use of an inhaler more often than prescribed by a doctor signals a deterioration in the patient's health and the progression of the disease.

How to use the inhaler:

• remove the cap;
• take a vertical position;
• shake the aerosol can thoroughly;
• exhale calmly and deeply;
• turn the can upside down.
• then you need to firmly press the mouthpiece to your mouth, repeating its shape with your lips, calmly inhale deeply and slowly, hold your breath for 10 seconds.
• Take the inhaler and breathe out slowly.

Once every 7 days, you need to clean the nozzle, after removing it from the cylinder. The spray cap is washed under running water, dried without the use of heating devices.

Avoid getting water on the bottle.

Application during pregnancy

Salbutamol AB is strictly prohibited for pregnant patients. During breastfeeding, it is allowed on prescription and if the potential benefit for the mother exceeds the harm to the baby.

Alcohol compatibility

Interaction with other drugs

Due to the increased risk of side effects and intoxication, caution should be combined with theophylline, ephedrine, corticosteroids, glycosides, MAO blockers, tricyclic antidepressants.

Antihypertensive drugs, nitrates, beta-blockers lose their effectiveness in combination with Salbutamol AB.

CNS stimulants, thyroid hormones are activated under the influence of the drug.

Overdose

The most common symptoms of acute intoxication with a medical agent are hyperkalemia, a drop in blood pressure, an accelerated heartbeat, vomiting, and muscle cramps. Less common are nervous excitement, hallucinations, respiratory alkalosis, paranoia.

Chronic intoxication has similar symptoms:

• lowering blood pressure,
• tachycardia,
• tachyarrhythmia,
• tremor,
• vomit,
• excitation,
• convulsions.

If signs of poisoning appear, symptomatic therapy is carried out, beta1-blockers are administered to suppress tachyarrhythmia.

Analogues

Ventolin-Evohaler, Salamol-Steri-Neb.

Terms of sale

Released by prescription.

Storage conditions

Store away from moisture at a temperature not exceeding 30 degrees Celsius in the original packaging, do not disassemble, pierce the cylinder.

In this article, you can read the instructions for using the drug Salbutamol. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Salbutamol in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Salbutamol analogues in the presence of existing structural analogues. Use for the treatment of bronchial asthma and relief of bronchospasm in adults, children, as well as during pregnancy and lactation. The composition of the drug.

Salbutamol- is a selective beta2-adrenergic antagonist. In therapeutic doses, it acts on the beta2-adrenergic receptors of the smooth muscles of the bronchi, providing a pronounced bronchodilator effect, prevents and relieves bronchospasm, and increases the vital capacity of the lungs. Prevents the release of histamine, a slow reacting substance from mast cells and neutrophil chemotaxis factors. It causes a slight positive chrono- and inotropic effect, dilates the coronary arteries and practically does not reduce blood pressure. It has a tocolytic effect: it lowers the tone and contractile activity of the myometrium.

It has a number of metabolic effects: it reduces plasma potassium, affects glycogenolysis and insulin release, has a hyperglycemic (especially in patients with bronchial asthma) and lipolytic effect, increases the risk of acidosis.

The action of the drug begins 5 minutes after inhalation and lasts for 4-6 hours.

Compound

Salbutamol sulfate + excipients.

Pharmacokinetics

After inhalation, 10 to 20% of the dose enters the respiratory tract. The rest stays in the device or settles in the oropharynx and is then swallowed. Part of the dose that remains in the respiratory tract is absorbed by the tissues of the lungs, without being metabolized in the lungs, and enters the bloodstream. When it enters the systemic circulation, it can be metabolized in the liver and excreted mainly in the urine unchanged or in the form of phenolic sulfate. The degree of binding of salbutamol to plasma proteins is 10%. Part of the dose that enters the gastrointestinal tract is absorbed and undergoes intensive metabolism during the "first pass" through the liver, turning into phenolic sulfate. The unchanged drug and conjugate are excreted primarily in the urine. Most of the dose of salbutamol administered intravenously, orally or inhaled, is excreted within 72 hours.

Indications

• prevention and relief of bronchospasm in bronchial asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema.

Release forms

Aerosol for inhalation dosed 100 mcg (sometimes erroneously called a spray).

Tablets 2 mg and 4 mg.

Instructions for use and dosage

Adults and children over 12 years of age: 100-200 mcg (1-2 inhalation doses) to relieve asthma attacks. To control the course of mild asthma - 1-2 doses 1-4 times a day and moderate severity of the disease - in the same dosage in combination with other anti-asthmatic drugs. For the prevention of physical effort asthma - 20-30 minutes before exercise 1-2 doses per dose.

The daily dose should not exceed 800 mcg (8 inhalations).

Instructions for using the inhaler

Check the operation of the inhaler before using it for the first time, and also if you have not used it for some time.

1. Remove the cap from the inhaler. Make sure the outlet tube is free of dust and dirt.
2. Hold the can upright with your thumb on the bottom and your index finger on the top of the can.
3. Shake the can vigorously up and down.
4. Exhale as deeply as possible (without tension). Close the outlet tube of the can tightly with your lips.
5. Take a slow deep breath. At the moment of inhalation, press the valve of the can with your index finger, releasing a dose of medicine. Continue to inhale slowly.
6. Remove the inhaler tube from your mouth and hold your breath for 10 seconds or as long as you can without exertion. Exhale slowly.

If more than one dose of medication is needed, wait about a minute and then repeat from step 2. Put the cap back on the inhaler.

When performing steps 3 and 4, take your time. It is important to inhale as slowly as possible when releasing a dose of medication. Practice in front of a mirror first. If you notice steam coming out of the top of the can or the corners of your mouth, start again from step 2.

Cleaning the inhaler

The inhaler should be cleaned at least once a week. Remove the metal can from the plastic case and rinse the case and cap with warm water. Do not use hot water. Dry thoroughly, but do not use heating devices for this. Place the can back into the case and put on the cap. Do not dip the metal can into water.

Side effect

• tremor of fingers;
• headache;
• dizziness;
• increased excitability;
• anxiety;
• sleep disturbance;
• insomnia;
• expansion of peripheral vessels (hyperemia of the skin of the face);
• the appearance of pain in the chest;
• arthralgia;
• angioedema;
• hives;
• nasal congestion;
• bronchospasm;
• muscle cramps;
• nausea, vomiting;
• dyspepsia;
• cough;
• excitement and increased motor activity in children;
• the appearance of arrhythmias (including atrial fibrillation, supraventricular tachycardia and extrasystole).

Contraindications

• rhythm disturbances (paroxysmal tachycardia, polytopic ventricular extrasystole);
• myocarditis;
• heart defects;
• aortic stenosis;
• cardiac ischemia;
• tachyarrhythmia;
• thyrotoxicosis;
• decompensated diabetes mellitus;
• glaucoma;
• epileptic seizures;
• pyloroduodenal narrowing;
• kidney or liver failure;
• simultaneous reception of non-selective beta-blockers;
• pregnancy;
• children's age up to 2 years;
• hypersensitivity to any component of the drug.

Use during pregnancy and lactation

Contraindicated in pregnancy.

During lactation, it is prescribed only in cases where the expected benefit to the mother outweighs any possible risk to the child.

Use in children

Children from 2 to 12 years of age: with the development of an attack of bronchial asthma, as well as to prevent attacks of bronchial asthma associated with exposure to an allergen or caused by physical activity, the recommended dose is 100-200 mcg (1 or 2 inhalations).

special instructions

In patients with severe or unstable asthma, the use of bronchodilators should not be the main or only therapy. If the effect of the usual dose of Salamol Eco becomes less effective or less prolonged (the effect of the drug should last at least 3 hours), the patient should consult a doctor.

Frequent use of salbutamol can lead to increased bronchospasm, sudden death, and therefore, between taking regular doses of the drug, it is necessary to take breaks of several hours.

An increased need for the use of inhaled beta2-adrenergic agonists with a short duration of action to control the symptoms of bronchial asthma indicates an exacerbation of the disease. In such cases, the patient's treatment plan should be reviewed and the issue of prescribing or increasing the dose of inhaled or systemic glucocorticosteroids (GCS) should be decided.

Therapy with beta2-adrenergic agonists can lead to hypokalemia. Particular caution is recommended in the treatment of severe attacks of bronchial asthma, since in these cases hypokalemia may increase as a result of the simultaneous use of xanthine derivatives, corticosteroids, diuretics, and also due to hypoxia. In such situations, it is necessary to control the level of potassium in the blood serum.

The salbutamol canister must not be punctured, disassembled, or thrown into a fire, even if it is empty. Like most other aerosol inhalants, salbutamol may be less effective at low temperatures. When cooling the cylinder, it is recommended to remove it from the plastic case and warm it with your hands for several minutes.

To determine the reversibility of bronchial patency and evaluate the effectiveness of the therapy, tests with bronchodilator drugs (bronchodilators), such as Salbutamol, are used.

This medicine contains ethanol (alcohol). This fact must be taken into account when driving a vehicle.

drug interaction

Theophylline and other xanthines, when used simultaneously with salbutamol, increase the likelihood of developing tachyarrhythmias; means for inhalation anesthesia, levodopa - severe ventricular arrhythmias.

MAO inhibitors and tricyclic antidepressants increase the effect of salbutamol and can lead to a sharp decrease in blood pressure.

Salbutamol enhances the action of CNS stimulants, side effects of thyroid hormones, cardiac glycosides.

Reduces the effectiveness of antihypertensive drugs, nitrates.

Hypokalemia may increase as a result of the simultaneous use of xanthine derivatives, corticosteroids, diuretics.

Simultaneous appointment with anticholinergics (including inhalation) may increase intraocular pressure.

Analogues of the drug Salbutamol

Structural analogues for the active substance:

• Aloprol;
• Astalin;
• Ventolin;
• Ventolin Nebula;
• Volmax;
• Salamol;
• Salamol Eco;
• Salmo;
• Salben;
• Salbuvent;
• Salbutamol Teva;
• Salbutamol hemisuccinate;
• Salbutamol sulfate;
• Salgim;
• Saltos;
• Sterineb Salamol;
• Cibutol Cyclocaps.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

Salbutamol-MF(Salbutamol-MF)

international and chemical name: Salbutamol, 2-tert-butylamino-1-(4-hydroxy-3-hydroxymethylphenyl)-ethanol sulfate;

Basic physical and chemical characteristics: white or white with a slightly yellowish tinge, homogeneous suspension;

Compound. 1 dose of aerosol includes 0.1 mg of salbutamol sulfate;

other components: sorbitan trioleate, freons 11 and 12.

Release form of the medicinal product. Aerosol for inhalation dosed.

Pharmacotherapeutic group. Means that are used in obstructive respiratory diseases. Adrenergic drugs for inhalation use. Selective agonists of b 2 -adrenergic receptors. ATC code R03A CO2.

The action of the drug. Pharmacodynamics. Salbutamol is a selective agonist b 2 -adrenergic receptors; it produces bronchodilation in patients with reversible airway obstruction, which occurs due to bronchial asthma, chronic bronchitis and emphysema. Salbutamol acts quickly and is therefore indicated for the emergency relief of asthma attacks or shortness of breath. It can also be used to prevent exercise-induced asthma symptoms. Since salbutamol has a selective effect on bronchial receptors and does not act on receptors in the heart, it can be prescribed to patients with concomitant heart disease or arterial hypertension.

Pharmacokinetics. After inhalation, 10-15% of the active substance enters the bronchi, the rest enters the digestive tract. 90% of the inhaled dose is absorbed from the bronchi. The bronchodilatory effect caused by the direct action of salbutamol on the bronchi begins after 10-15 minutes and lasts at least 3 hours. The duration of action is 4-6 hours. There is no evidence that the metabolism of salbutamol occurs in the lungs. When a drug is inhaled, its effect on the body depends on the technique of inhalation and is determined by comparing the dose that is inhaled and the dose that is swallowed. In the case of prolonged use of salbutamol, the sensitivity of the receptors decreases, therefore, the effect of its action decreases. A small dose of the drug enters the digestive tract, so its pharmacokinetics are not significant.

Indications for use. Relief and prevention of an asthma attack with; and emphysema. Obstructive syndrome in children. Bronchospasm of various origins. Prevention of an asthma attack associated with physical exertion or possible contact with allergens.

Method of use and dosage. The drug is used by inhalation.

Adults and children over 4 years old. In acute bronchospasm - 1 - 2 inhalation doses of Salbutamol-MF (the next dose is not earlier than after 4 hours). Prevention of asthma attacks due to exercise - 2 doses before exercise. Prevention before possible contact with the foreseen allergen - inhalation 1 dose in 10-15 minutes.

With long-term use of salbutamol – 1-2 inhalations 3-4 times a day with an interval of at least 3 hours. Do not use more than 10 doses per day.

Children over 2 years old. For the relief of asthma attacks - 1 inhalation once. When conducting systemic therapy - 1 inhalation 3-4 times a day.

Side effect. Therapy with b 2 -sympathomimetics can cause significant hypokalemia. This effect may be enhanced by the simultaneous use of xanthine derivatives, steroids, diuretics or hypoxia. Other important adverse reactions when using salbutamol in the form of an aerosol do not occur. At higher doses or in sensitive patients, peripheral vasodilation with mild compensated tachycardia may occur. Rarely, mild skeletal muscle tremors, primarily of the arms, muscle tremors, temporary spasms, and headache may occur during therapy with salbutamol. Very rarely, reactions associated with hypersensitivity appear: vascular edema, bronchospasm, hypotension and collapse.

Contraindications. The drug is contraindicated in case of allergy to any of its components. Children under 2 years of age, I and II trimester of pregnancy in case of toxicosis or threat of abortion.

Overdose.

Symptoms: trembling, tachycardia, mental stress, headache, lowering blood pressure. Treatment is symptomatic. There is no specific antidote. Usually (with the exception of cases of bronchospasm) the use of cardioselective b-blockers is preferred. The use of large doses of b-blockers should be avoided due to the risk of bronchospasm in sensitive individuals.

Features of use. It is recommended to monitor the level of potassium in the blood, especially in the case of severe bronchial asthma. The drug should be used with caution in patients with hypersensitivity to salbutamol, with thyrotoxicosis, serious cardiovascular diseases (coronary heart disease, arrhythmia), arterial hypertension, diabetes, and ketoacidosis.

Although salbutamol is used as a tocolytic, it is not indicated for the treatment of threatened abortion in the first and second trimesters of pregnancy.

When using an aerosol, it is necessary to protect the eyes from getting aerosol particles into them.

Pregnancy and lactation. During pregnancy, it can be used only for health reasons. Since salbutamol passes into breast milk, its use during lactation is possible only in this case, when the expected therapeutic effect for the mother outweighs the potential risk to the child.

Influence on the ability to drive vehicles and other mechanisms

The use of salbutamol in high doses may worsen the reaction when driving a car or operating machinery. This action is enhanced by the simultaneous use of alcohol, tranquilizers.

Interaction with other drugs. Salbutamol should not be co-administered with non-selective beta-blockers (including topical eye preparations that contain beta-blockers). The parallel use of cardioselective beta-blockers does not reduce the effect of salbutamol.

Simultaneous treatment with xanthine derivatives, diuretics and corticosteroids may contribute to the appearance of severe hypokalemia. Also, general anesthetics, tricyclic antidepressants and maprotiline, ergotamine and MAO inhibitors should not be used together with salbutamol. In the case of the simultaneous use of salbutamol and cardiac glycosides, the risk of hypokalemia due to the use of beta-agonists increases.

Terms and conditions of storage. At a temperature not higher than +25°С. Avoid exposure to direct sunlight and freezing. The container is under pressure. Do not throw into fire or destroy even after use. Keep out of the reach of children.

Shelf life - 2 years.

The drug is dispensed by prescription.

It is included in the list of medicines dispensed by prescription when providing additional free medical care to certain categories of citizens who are entitled to receive state social assistance.

TRADE NAMES

Salbutamol, Ventolin, Astalin, Ventokol, Salamol, Salben, Salgim, Saltos, Sterineb Salamol, Cibutol Cyclocaps.

DRUG FORMS

Tablets.
Aerosol for inhalation dosed.
Capsules with powder for inhalation.
Powder for inhalation dosed.
Syrup.

HOW DOES THE DRUG WORK?

The drug belongs to the group of β-adrenergic agonists, relaxes the muscles of the airways and thereby increases the air flow, making breathing easier.

IN WHAT CASES IS THE MEDICINE PRESCRIBED?

For the prevention and relief of bronchospasm in bronchial asthma.
For the treatment of broncho-obstructive syndrome in chronic obstructive pulmonary disease, chronic bronchitis.
With nocturnal asthma.
To prevent premature birth.

DRUG APPLICATION

RECEPTION RULES
To stop the onset of an asthma attack, take 1-2 doses as an inhaler.

If there is no effect after 5 minutes, repeated inhalation is possible. The maximum frequency of reception is 6 times a day.

Sometimes the drug is prescribed for regular use - 1-2 inhalations 2-4 times a day, for the prevention of so-called cold asthma - 15-20 minutes before contact with frosty air.

In case of a severe attack, it is possible to administer a solution for inhalation using a nebulizer (an apparatus for spraying the substance into the smallest particles and subsequent inhalations) for 5-15 minutes, the interval between inhalations is 4 hours. The drug solution should be injected into the nebulizer in an amount of 2.5-5 ml diluted with saline.

Powder for inhalation is taken using an individual portable inhaler "Cyclohaler", for the relief of attacks of bronchial asthma, take 1-2 doses per dose (200-400 mcg), for the prevention and treatment of bronchial asthma, 1-4 doses 1-4 times a day in depending on the severity of the disease.

It is possible to take orally, as an aid in case of ineffectiveness of inhalation forms, 1 tablet 3-4 times a day.

With the threat of miscarriage, take 1 tablet (4 mg) orally every 2-3 hours, then for 2 days - 1 tablet every 4 hours, in the following days - 1 tablet every 6 hours for several days until the uterine contractions completely stop .

The dosage depends on the severity of the disease and the response to the therapy, it should be determined by the attending physician.

It is important to remember that taking high doses of salbutamol during an exacerbation of asthma leads to the fact that each subsequent attack of suffocation becomes more intense than the previous one (the "rebound" syndrome).

With a severe attack of suffocation, the interval between inhalations should be at least 20 minutes. In the absence of a minimal effect from inhalation or the appearance of a pronounced tremor, rapid and irregular heartbeat, further uncontrolled use of the inhaler is contraindicated and a visit to a doctor is necessary. inhale long enough, hold your breath after inhalation of the drug for 10 s). If it is difficult to perform the correct breathing maneuver, it is recommended to use special devices (spacers) for inhalation of the drug, which increase the tidal volume and smooth out inaccuracies of asynchronous inspiration.

While taking salbutamol, it is desirable to carry out some diagnostic tests, including a study of the function of external respiration to evaluate the effectiveness of treatment and prevent the development of adverse reactions.

It is necessary to use a peak flow meter at home daily and timely detect worsening of the disease.

Allergens and irritants (tobacco smoke, dust, pet hair, mold) should be avoided as they can trigger an asthma attack.

DURATION OF RECEPTION
The optimal reception is the use of the drug on demand during an attack of bronchospasm. With constant use, the duration of the course of treatment is determined by the doctor. You can stop taking the medicine and change the dosage only after consulting a specialist. Symptoms of the disease can worsen sharply with abrupt withdrawal of the drug, the dose should be reduced gradually.

IF YOU MISS A DOSE
If you take salbutamol regularly, if you miss a dose, take the medicine as soon as you remember. If the time is close to the next inhalation, skip the dose and take the medicine as usual. Do not take a double dose of the drug.

OVERDOSE
In case of an overdose, symptoms such as headache, palpitations, dangerous cardiac arrhythmias, peripheral vasodilation, decreased blood pressure, muscle tremor, mental disorders, changes in laboratory parameters may appear. ). In patients with bronchial asthma, it should be administered with caution due to the possible development of bronchospasm.

EFFICIENT AND SAFE TREATMENT

CONTRAINDICATIONS
Individual intolerance. Ischemic heart disease, increased blood pressure, rhythm disturbances, heart failure, hyperthyroidism, pheochromocytoma, impaired renal function, I trimester of pregnancy, breast milk feeding period.

SIDE EFFECTS
Symptoms such as dizziness, headache, increased and irregular heart rhythm, decreased blood pressure, chest pain, angina pectoris, heart failure, pulmonary edema (possible death), redness of the face, agitation, nausea, vomiting, dry mouth , loss of appetite, difficulty urinating, sweating, increased blood glucose, hypokalemia, the development of physical and mental drug dependence.

If any of these symptoms persist for a long time or worsen, see your doctor.

To relieve dry mouth, use sugar-free lozenges or chewing gum, an ice cube, or saliva substitutes.

Remember that the drug was prescribed to you taking into account the fact that the benefits of it far outweigh the risk of side effects.

IT IS NECESSARY TO INFORM YOUR DOCTOR
You have heart problems (irregular heartbeat, angina pectoris), high blood pressure, diabetes, liver disease, hypokalemia, thyroid disease.
You have ever had an allergic reaction to any medicine.
You are taking any other drugs, including over-the-counter drugs, herbs, and dietary supplements.

If you are pregnant
The drug is contraindicated in the first trimester of pregnancy.

If you are breastfeeding
The drug is contraindicated.

If you drive a car or operate machinery
No data.

If you are over 60
No data.

If you give the drug to children
Contraindicated up to 6 years in the form of tablets, up to 2 years in the form of an oral solution and syrup.

INTERACTIONS
Use with other drugs
Do not stop or start taking any medication without first talking to your doctor. Salbutamol increases the activity of stimulants of the central nervous system, enhances the effect of thyroid hormones on the heart.

The simultaneous administration of glucocorticoids, prostaglandin synthesis inhibitors, psychotropic drugs (tricyclic antidepressants and MAO blockers) is not recommended, as this increases the risk of developing cardiovascular complications.

Means for inhalation anesthesia and levodopa, when combined with salbutamol, increase the risk of developing severe ventricular arrhythmias.

Salbutamol reduces the effectiveness of β-blockers (including those used for eye diseases), antihypertensive agents, weakens the analgesic effect of nitrates.

The drug potentiates the likelihood of side effects of cardiac glycosides.

Salbutamol is compatible with anti-asthma drugs of other pharmacological groups (glucocorticoids, antiallergic, expectorants).

Alcohol
Alcohol should be avoided during treatment.

STORAGE RULES
Store at a temperature not exceeding 30 ° C in a dry place, protected from direct sunlight, out of the reach of children.