Tablets "Ambrobene" for children: instructions for use. How to take Ambrobene cough tablets according to the instructions for use? Ambrobene instructions for use of tablets 30

Product SKU: NME0KL
Price: 68,6

Release form:
tablets
Package:
20 tablets
Dosage:
30mg

Description:

Indications for use of the drug AMBROBEN

All forms of the drug are used for diseases of the respiratory tract with the release of viscous sputum and difficulty in its discharge:

Acute and chronic bronchitis;

Pneumonia;

Bronchial asthma;

bronchiectasis;

As part of complex therapy to stimulate the synthesis of surfactant in respiratory distress syndrome in premature infants and newborns (injection solution).

pharmachologic effect

Mucolytic and expectorant drug.

Ambroxol, an active metabolite of bromhexine, improves the rheological properties of sputum, reduces its viscosity and adhesive properties, contributing to its removal from the respiratory tract.

Ambroxol stimulates the activity of serous cells of the glands of the bronchial lining, the production of enzymes that break down the bonds between sputum polysaccharides, the formation of a surfactant and the activity of the bronchial cilia directly, preventing them from sticking together.

After oral administration, the therapeutic effect occurs after 30 minutes and lasts for 6-12 hours (depending on the dose taken).

With parenteral administration, the effect of the drug occurs quickly and lasts for 6-10 hours.

Pharmacokinetics

Suction and distribution

When administered parenterally, Ambroxol quickly penetrates the tissues. The highest concentration is found in the lungs. Cmax in blood plasma is reached in 1-3 hours.

About 80% of the drug binds to plasma proteins. Ambroxol penetrates the BBB and the placental barrier, is excreted in breast milk.

Metabolism and excretion

The drug is metabolized in the liver by conjugation with the formation of pharmacologically inactive metabolites.

About 90% of ambroxol is excreted in the urine: 90% of them are in the form of metabolites and 10% are unchanged.

Pharmacokinetics in special clinical situations

At severe liver disease Ambroxol clearance is reduced by 20-40%.

At severe renal dysfunction increases T 1/2 ambroxol and its metabolites.

Dosing regimen

The drug should be taken orally after a meal with a sufficient amount of liquid (a glass of water, tea or juice).

Tablets in the first 2-3 days appoint 1 tablet 3 times / day. (90 mg/day). Subsequently, they switch to a 2-time dose of the drug, 1/2 tablet / day. (30 mg/day).

In the first 2-3 days, 1/2 tablet is prescribed 2-3 times / day. (30-45 mg/day). Subsequently, they switch to a two-time dose of the drug, 1/2 tablet / day. (30 mg/day).

Retard capsulesadults and children over the age of 12 appoint 1 capsule / day. (75 mg/day).

Syrup should be taken with a measuring cup: 1 ml of syrup contains 3 mg of ambroxol.

Children under 2 years old prescribe the drug 2.5 ml of syrup 2 times / day. (15 mg/day).

Assign the drug 2.5 ml of syrup 3 times / day. (22.5 mg/day).

Children aged 6 to 12 prescribe the drug 5 ml of syrup 2-3 times / day. (30-45 mg/day).

Adults and children over the age of 12 during the first days, 10 ml of syrup 3 times / day. (90 mg/day). Subsequently, 10 ml of syrup 2 times / day. (60 mg/day).

Ambrobene in the form of syrup is the most convenient dosage form for the treatment of pediatric patients.

Solution for oral and inhalation inside should be taken with a measuring cup: 1 ml of the solution contains 7.5 mg of ambroxol.

Children under 2 years old prescribe the drug 1 ml of solution 2 times / day. (15 mg/day).

Children aged 2 to 6 years prescribe the drug 1 ml of solution 3 times / day. (22.5 mg/day).

Children aged 6 to 12 prescribe the drug in 2 ml of solution 2-3 times / day. (30-45 mg/day).

Adults and teenagers in the first 2-3 days appoint 4 ml of solution 3 times / day. (90 mg/day). In the following days - 4 ml 2 times / day. (60 mg/day).

When applied Ambrobene as inhalations use any modern equipment (except for steam inhalation). Before inhalation, the drug should be mixed with a 0.9% sodium chloride solution (for optimal air humidification, it can be diluted in a ratio of 1:1) and heated to body temperature. Inhalations should be carried out in the mode of normal breathing, so as not to provoke coughing shocks.

In patients with bronchial asthma, in order to avoid non-specific irritation of the respiratory tract and their spasm, bronchodilators should be used before inhalation of ambroxol.

Children under 2 years old inhaled 1 ml of solution 1-2 times / day. (7.5-15 mg/day).

Children aged 2 to 6 years inhaled 2 ml of solution 1-2 times / day. (15-30 mg/day).

Adults and children over 6 years of age inhaled 2-3 ml of solution 1-2 times / day. (15-45 mg/day).

Injection should be administered in/in (slow jet or drip). As a solvent, 0.9% sodium chloride solution, 5% dextrose solution, Ringer-Locke solution or other basic solution with a pH not higher than 6.3 is used.

children usually the drug is prescribed in a daily dose at the rate of 1.2-1.6 mg / kg of body weight.

Children under 2 years old appoint 1 ml (1/2 amp.) 2 times / day. (15 mg/day).

Children aged 2 to 6 years appoint 1 ml (1/2 amp.) 3 times / day. (22.5 mg/day).

Children over 6 years of age appoint 2 ml (1 amp.) 2-3 times / day. (30-45 mg/day).

Adults appoint 1 amp. 2-3 times / day. (30-45 mg/day). In severe cases, the dose may be increased to 2 amps. 2-3 times / day. (60-90 mg/day).

At respiratory distress syndrome in newborns and premature babies the daily dose of the drug is 30 mg and is usually divided into 4 separate injections.

Injections are stopped after the disappearance of acute manifestations of the disease and are switched to ingestion of other dosage forms. Ambrobene .

Treatment children under 2 years old should only be done under medical supervision.

The duration of the course of treatment depends on the characteristics of the course of the disease. It is not recommended to use the drug without medical prescription for more than 4-5 days.

Side effect

From the digestive system: rarely - salivation, gastralgia, nausea, vomiting, diarrhea, constipation.

From the respiratory system: rarely - dry mouth and respiratory tract, rhinorrhea.

Allergic reactions: very rarely - skin rash, angioedema of the face, respiratory failure, temperature reaction with chills; in some cases - contact dermatitis, anaphylactic shock.

Others: weakness, headache, dysuria, exanthema.

With rapid on / in the introduction: intense headaches, fatigue and heaviness in the legs, numbness, increased blood pressure, shortness of breath, hyperthermia, chills.

Contraindications to the use of the drug AMBROBEN

Peptic ulcer of the stomach and duodenum;

epileptic syndrome;

Children under 6 years of age (for tablets, retard capsules, injection solution);

Children under 12 years of age (for retard capsules);

Hypersensitivity to the components of the drug.

FROM caution the drug should be used in case of impaired renal function and severe liver disease, reducing the dose and increasing the time between doses of the drug (treatment in such cases should be carried out under medical supervision).

FROM special care and should only be used under medical supervision Ambrobene in violation of bronchial motility and large volumes of excreted secretion in order to avoid the risk of stagnation of secretion in the bronchi.

The use of the drug AMBROBENE during pregnancy and lactation

Since so far there is no reliable data on the negative effect of ambroxol on the fetus and newborn, apply Ambrobene during pregnancy, especially in the first trimester, and during breastfeeding is possible only if the intended benefit to the mother outweighs the potential risk to the fetus.

Application for violations of liver function

FROM caution the drug should be used in severe liver disease, reducing the dose and increasing the time between doses of the drug (treatment in such cases should be carried out under medical supervision).

Application for violations of kidney function

FROM caution the drug should be used in case of impaired renal function, reducing the dose and increasing the time between doses of the drug (treatment in such cases should be carried out under medical supervision).

special instructions

There are no specific instructions for the drug.

Overdose

Ambroxol is well tolerated when taken orally at a dose of up to 25 mg/kg/day.

Symptoms: increased salivation, nausea, vomiting, decreased blood pressure.

Treatment: gastric lavage in the first 1-2 hours after taking the drug, taking fat-containing foods. Hemodynamic parameters should be monitored. If necessary, symptomatic therapy should be carried out.

drug interaction

Simultaneous use Ambrobene with drugs with antitussive activity (for example, containing codeine), it is not recommended due to the difficulty in removing sputum from the bronchi against the background of a decrease in cough.

Simultaneous use Ambrobene with antibiotics (including amoxicillin, cefuroxime, erythromycin, doxycycline) improves the flow of antibiotics into the pulmonary tract. This interaction with doxycycline is widely used therapeutically.

Cannot be used for mixture injection Ambrobene with solutions having a pH above 6.3.

Terms of dispensing from pharmacies

The drug in the form of tablets, retard capsules, oral solution and inhalation, syrup is approved for use as a non-prescription drug.

The drug in the form of a solution for injection is dispensed by prescription.

Terms and conditions of storage

Tablets, retard capsules should be stored out of the reach of children under normal conditions. Shelf life - 5 years.

The solution for oral administration and inhalation should be stored at a temperature not exceeding 25 ° C. Shelf life - 5 years.

The shelf life of the syrup is 4 years.

List B. The solution for injection should be stored under normal conditions. Shelf life - 4 years.

Composition and form of release

Tablets - 1 tab.:

Active substance: ambroxol hydrochloride 30 mg.
Excipients: lactose monohydrate - 169.46 mg, corn starch - 36.33 mg, magnesium stearate - 2.41 mg, anhydrous colloidal silicon dioxide - 1.8 mg.

10 pieces. - blisters (2) - cardboard boxes.

Description of the dosage form

Tablets are white, round, biconvex, with a dividing risk on one side, the other side is smooth.

pharmachologic effect

Ambroxol is a benzylamine, a metabolite of bromhexine. It differs from bromhexine in the absence of a methyl group and the presence of a hydroxyl group in the para-trans position of the cyclohexyl ring. It has a secretomotor, secretolytic and expectorant action.

After oral administration, the effect occurs after 30 minutes and lasts for 6-12 hours (depending on the dose taken).

Preclinical studies have shown that ambroxol stimulates the serous cells of the glands of the bronchial mucosa. By activating the cells of the ciliated epithelium and reducing the viscosity of sputum, it improves mucociliary transport.

Ambroxol activates the formation of surfactant, having a direct effect on type 2 alveolar pneumocytes and Clara cells of small airways.

Studies on cell cultures and in vivo studies on animals have shown that ambroxol stimulates the formation and secretion of a substance (surfactant) active on the surface of the alveoli and bronchi of the embryo and adult.

Also, in preclinical studies, the antioxidant effect of ambroxol has been proven.

Ambroxol, when used together with antibiotics (amoxicillin, cefuroxime, erythromycin and doxycycline), increases their concentration in sputum and bronchial secretions.

Pharmacokinetics

Absorption, distribution, metabolism

When taken orally, Ambroxol is almost completely absorbed from the gastrointestinal tract. Cmax is reached 1-3 hours after ingestion. Due to first pass metabolism, the absolute bioavailability of ambroxol after oral administration is reduced by approximately 1/3. The resulting metabolites (such as dibromoanthranilic acid, glucuronides) are eliminated by the kidneys. Plasma protein binding is about 85% (80-90%).

Ambroxol penetrates into the cerebrospinal fluid and through the placental barrier, and is also excreted in breast milk.

breeding

T1 / 2 from plasma is from 7 to 12 hours. The total T1 / 2 of ambroxol and its metabolites is approximately 22 hours. Excreted mainly by the kidneys as metabolites - 90%, less than 10% is excreted unchanged.

Given the high binding to plasma proteins, large Vd and slow redistribution from tissues to the blood, there is no significant elimination of ambroxol during dialysis or forced diuresis.

Pharmacokinetics in special clinical situations

In patients with severe liver disease, ambroxol clearance is reduced by 20-40%.

In patients with severely impaired renal function, T1 / 2 of ambroxol metabolites increases.

Pharmacodynamics

After oral administration, the therapeutic effect occurs after 30 minutes and lasts for 6-12 hours (depending on the dose taken). With parenteral administration, the action occurs quickly and lasts for 6-10 hours.

Clinical pharmacology

Mucolytic and expectorant drug.

Indications for use

Acute and chronic diseases of the respiratory tract, accompanied by a violation of the formation and discharge of sputum.

Contraindications for use

fructose intolerance, sucrase/isomaltase deficiency, glucose-galactose malabsorption;
I trimester of pregnancy;
hypersensitivity to the components of the drug.

With caution, the drug should be used in patients with impaired motor function of the bronchi and increased sputum production (with immobile cilia syndrome), with peptic ulcer of the stomach and duodenum in the acute phase, in the II and III trimesters of pregnancy, during lactation.

Patients with impaired renal function or severe liver disease Ambrobene should be prescribed with extreme caution, while patients should observe large intervals between doses or take the drug at a lower dose.

Use in pregnancy and children

There are insufficient data on the use of ambroxol during pregnancy, especially in the first 28 weeks. The use of Ambrobene in the II and III trimesters of pregnancy is possible only on prescription, after a thorough assessment of the expected benefits of therapy for the mother and the potential risk to the fetus.

The use of the drug in women during lactation has not been studied enough, therefore, taking Ambrobene is possible only as directed by a doctor, after a thorough assessment of the ratio of the expected benefit of therapy for the mother and the potential risk to the infant.

In experimental studies on animals, no teratogenic effect has been identified; Ambroxol has been shown to be excreted in breast milk.

Use in children

The drug in the form of tablets and solution for injection is contraindicated for use in children under the age of 6 years.

Side effects

Allergic reactions: rarely (from ≥0.1% to<1%) - крапивница, кожная сыпь, ангионевротический отек лица, одышка, зуд); очень редко (<0.01%) - анафилактические реакции, в т.ч. анафилактический шок.

From the digestive system: rarely (from ≥0.1% to<1%) - тошнота, боли в животе, рвота, диарея, запоры.

General disorders: rare (≥0.1% to<1%) - лихорадка, слабость, головная боль.

Others: rarely (from ≥0.1% to<1%) - сухость слизистой оболочки полости рта и дыхательных путей, экзантемы, ринорея, дизурия.

drug interaction

With the simultaneous use of ambroxol and antitussives, due to the suppression of the cough reflex, secretion stagnation may occur. Therefore, such combinations should be chosen with caution.

With the joint use of ambroxol and antibiotics amoxicillin, cefuroxime, erythromycin and doxycycline, the concentration of the latter in sputum and bronchial secretions increases.

Dosage

The duration of treatment is set individually depending on the course of the disease. It is not recommended to take Ambrobene without a doctor's prescription for more than 4-5 days. The mucolytic effect of the drug is manifested when taking a large amount of liquid. Therefore, during treatment, it is recommended to drink plenty of water.

Tablets

Tablets should be swallowed whole, without chewing, after meals, drinking plenty of liquid.

Children aged 6 to 12 years should take 1/2 tab. 2-3 times / day (15 mg ambroxol 2-3 times / day).

Adults and children over 12 years old in the first 2-3 days of treatment should take 1 tab. 3 times / day (30 mg ambroxol 3 times / day). With the ineffectiveness of therapy, adults can increase the dose to 2 tab. 2 times / day (120 mg ambroxol / day). In the following days, you should take 1 tab. 2 times / day (30 mg ambroxol 2 times / day).

Overdose

Symptoms: symptoms of intoxication with an overdose of ambroxol have not been identified. There are reports of nervous excitement and diarrhea. Ambroxol is well tolerated when taken orally at a dose of up to 25 mg/kg/day. In case of severe overdose, increased salivation, nausea, vomiting, and a decrease in blood pressure are possible.

Treatment: intensive therapy methods, such as induction of vomiting, gastric lavage, should be used only in cases of severe overdose, in the first 1-2 hours after taking the drug. Symptomatic treatment is shown.

Precautionary measures

It should not be combined with antitussive drugs that make it difficult to remove sputum.

Extremely rarely, when taking Ambrobene, severe skin reactions were observed, such as Stevens-Johnson syndrome and Lyell's syndrome. If the skin or mucous membranes change, the patient should immediately consult a doctor and stop taking the drug.

Influence on the ability to drive vehicles and control mechanisms

The effect on the ability to drive vehicles and control machines and mechanisms is not known to date.

1 tablet contains Ambroxol hydrochloride 30 mg

Release form:

Tablets for oral administration - 20 pieces per pack

Pharmachologic effect:

Mucolytic and expectorant drug

After oral administration, the effect occurs after 30 minutes and lasts for 6-12 hours (depending on the dose taken).

Indication for use:

Acute and chronic diseases of the respiratory tract, accompanied by a violation of the formation and discharge of sputum.

Dosage and administration:

Tablets should be swallowed whole, without chewing, after meals, drinking plenty of liquid.

Children aged 6 to 12 years should take 1/2 tab. 2-3 times / day (15 mg ambroxol 2-3 times / day).

Contraindications:

I trimester of pregnancy;
children's age up to 6 years;
lactose intolerance, lactase deficiency, glucose-galactose malabsorption (for tablets);
hypersensitivity to the components of the drug.

Special instructions:

It should not be combined with antitussive drugs that make it difficult to remove sputum.

Storage conditions:

Tablets should be stored out of the reach of children at a temperature not exceeding 25 ° C.

Mucolytic and expectorant drug

Active substance

Release form, composition and packaging

◊ Tablets white, round, biconvex, with a dividing risk on one side, the other side is smooth.

Excipients: lactose monohydrate - 169.46 mg, corn starch - 36.33 mg, magnesium stearate - 2.41 mg, anhydrous colloidal silicon dioxide - 1.8 mg.

10 pieces. - blisters (2) - cardboard boxes.

pharmachologic effect

Mucolytic and expectorant drug.

Ambroxol is a benzylamine metabolite. It differs from bromhexine in the absence of a methyl group and the presence of a hydroxyl group in the para-trans position of the cyclohexyl ring. It has a secretomotor, secretolytic and expectorant effect.

After oral administration, the effect occurs after 30 minutes and lasts for 6-12 hours (depending on the dose taken).

Ambroxol activates the formation of surfactant, having a direct effect on type 2 alveolar pneumocytes and Clara cells of small airways.

Also, in preclinical studies, the antioxidant effect of ambroxol has been proven.

Ambroxol, when used together with antibiotics (cefuroxime, erythromycin and doxycycline), increases their concentration in sputum and bronchial secretions.

Pharmacokinetics

Absorption, distribution, metabolism

When taken orally, Ambroxol is almost completely absorbed from the gastrointestinal tract. C max is achieved 1-3 hours after ingestion. Due to first pass metabolism, the absolute bioavailability of ambroxol after oral administration is reduced by approximately 1/3. The resulting metabolites (such as dibromoanthranilic acid, glucuronides) are eliminated by the kidneys. Protein binding is about 85% (80-90%).

Ambroxol penetrates into the cerebrospinal fluid and through the placental barrier, and is also excreted in breast milk.

breeding

T 1 / 2 from plasma is from 7 to 12 hours. The total T 1 / 2 of ambroxol and its metabolites is approximately 22 hours. It is excreted mainly by the kidneys in the form of metabolites - 90%, less than 10% is excreted unchanged.

Given the high binding to plasma proteins, large V d and slow redistribution from tissues to the blood, there is no significant elimination of ambroxol during dialysis or forced diuresis.

Pharmacokinetics in special clinical situations

In patients with severe liver disease, ambroxol clearance is reduced by 20-40%.

In patients with severely impaired renal function, T 1/2 of ambroxol metabolites increases.

Indications

- acute and chronic diseases of the respiratory tract, accompanied by a violation of the formation and discharge of sputum.

Contraindications

- I trimester of pregnancy;

- children's age up to 6 years;

- lactose intolerance, lactase deficiency, glucose-galactose malabsorption (for tablets);

- Hypersensitivity to the components of the drug.

FROM caution the drug should be used in patients with impaired motor function of the bronchi and increased sputum production (with immobile cilia syndrome), with peptic ulcer of the stomach and duodenum in the acute phase, in the II and III trimesters of pregnancy, during lactation.

Patients with impaired renal function or severe liver disease should be given with special care, while patients should observe large intervals between doses or take the drug at a lower dose.

Dosage

Tablets

Tablets should be swallowed whole, without chewing, after meals, drinking plenty of liquid.

Children aged 6 to 12 should be taken 1/2 tab. 2-3 times / day (15 mg ambroxol 2-3 times / day).

Adults and children over 12 years old in the first 2-3 days of treatment should take 1 tab. 3 times / day (30 mg ambroxol 3 times / day). With the ineffectiveness of therapy, adults can increase the dose to 2 tab. 2 times / day (120 mg ambroxol / day). In the following days, you should take 1 tab. 2 times / day (30 mg ambroxol 2 times / day).

Side effects

Allergic reactions: rarely (from ≥0.1% to<1%) - крапивница, кожная сыпь, ангионевротический отек лица, одышка, зуд); очень редко (<0.01%) - анафилактические реакции, в т.ч. анафилактический шок.

From the digestive system: rarely (from ≥0.1% to<1%) - тошнота, рвота, диарея, запоры.

General violations: rarely (from ≥0.1% to<1%) - лихорадка, слабость, головная боль.

Others: rarely (from ≥0.1% to<1%) - сухость слизистой оболочки полости рта и дыхательных путей, экзантемы, ринорея, дизурия.

Overdose

Symptoms: symptoms of intoxication with an overdose of ambroxol have not been identified. There are reports of nervous excitement and diarrhea. Ambroxol is well tolerated when taken orally at a dose of up to 25 mg/kg/day. In case of severe overdose, increased salivation, nausea, vomiting, and a decrease in blood pressure are possible.

Treatment: intensive care methods, such as induction of vomiting, gastric lavage, should be used only in cases of severe overdose, in the first 1-2 hours after taking the drug. Symptomatic treatment is shown.

drug interaction

With the simultaneous use of ambroxol and antitussives, due to the suppression of the cough reflex, secretion stagnation may occur. Therefore, such combinations should be chosen with caution.

With the joint use of ambroxol and antibiotics amoxicillin, erythromycin and doxycycline, the concentration of the latter in sputum and bronchial secretions increases.

special instructions

It should not be combined with antitussive drugs that make it difficult to remove sputum.

Influence on the ability to drive vehicles and control mechanisms

The effect on the ability to drive vehicles and control machines and mechanisms is not known to date.

Pregnancy and lactation

AT experimental studies no teratogenic effect has been found in animals; Ambroxol has been shown to be excreted in breast milk.

Application in childhood

The drug in the form of tablets and solution for injection is contraindicated for use in children under the age of 6 years.
The drug in the form of retard capsules is contraindicated for use in children under the age of 12 years.

Treatment children under 2 years old should only be done under medical supervision.

For impaired renal function

For impaired liver function

Terms of dispensing from pharmacies

The drug is approved for use as a means of OTC.

Terms and conditions of storage

The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C. Shelf life - 5 years.

From cough

no temperature

With temperature

Massage

For bronchitis, pneumonia or other diseases with a strong cough and viscous sputum, doctors often prescribe the German drug Ambrobene. It is presented in various dosage forms, among which there are also tablets. But is it possible to treat a small child with Ambrobene tablets and at what dose can they be used in childhood?

Release form

The tablet form of Ambrobene is represented by round tablets convex on both sides, on which there is a risk for possible separation. These white tablets are packaged in blister packs of 10, and one pack contains 20 or 50 tablets.

Compound

The active substance in Ambrobene is ambroxol hydrochloride. Its content in each tablet of the drug is 30 mg. Additionally, in tablet form, there are substances that provide density and shape retention - magnesium stearate, colloidal silicon dioxide, starch obtained from corn and lactose monohydrate.

Operating principle

Ambroxol has the ability to activate sputum production and improve its separation. The medicine taken orally begins to act in half an hour. The duration of the therapeutic effect is from 6 to 12 hours, depending on the dosage. Once in the bronchial mucosa, Ambrobene affects glandular cells and ciliated epithelium. The drug reduces the viscosity of the secret secreted by the bronchi, which contributes to the expectoration of mucus.

Ambroxol also has the ability to activate the production of surfactant. The compound directly affects the cells of the respiratory tract responsible for the production of this important substance for respiration. Studies have also shown some antioxidant activity of Ambrobene.

Indications

The drug is prescribed for:

SARS.
Bronchitis.
bronchiectasis.
Pneumonia.
Obstructive lung diseases.

At what age is it allowed to take?

Ambrobene tablets are not prescribed to children who are not yet six years old. For babies, a syrup or solution is considered a more suitable form of medicine, which can be prescribed under the supervision of a doctor from birth.

Contraindications

If the child has an individual intolerance to ambroxol or another component of the tablets.
If glucose-galactose malabsorption is detected or there are problems with the digestion of lactose.

Children with peptic ulcer, liver pathologies or kidney diseases should not drink Ambrobene without consulting a doctor. With such health problems, the medicine is prescribed carefully and in a lower dosage.

Side effects

The child's body may react to Ambroxol with such negative symptoms:

Weakness
fever
Headaches
Nausea
skin rash
vomit
Shortness of breath
Itchy skin
Pain in the abdomen
Constipation
Dry mouth
diarrhea
Dysuria
Urticaria
Copious discharge from the nose

Instructions for use and dosage

Ambrobene tablet should be swallowed whole, and chewing the medicine is not recommended. After drinking such a tablet after a meal, you should drink it with a large amount of liquid.
For children 6-12 years old, a single dosage of the tableted drug Ambrobene is represented by half a tablet. The medicine is given twice a day, but in some cases a three-time dose is prescribed.
At the age of over 12 years, a single dose of the drug is increased to a whole tablet taken three times a day. If after 2-3 days from the start of therapy the effectiveness of the drug is too low, it is possible to increase the single dose to 2 tablets. With a good effect, the medicine continues to be given 1 tablet twice a day.
How much to take Ambrobene, the doctor determines for each small patient individually. If the mother began to give the medication without contacting the pediatrician, the treatment should not last more than 4-5 days.
For a more pronounced mucolytic effect, attention should be paid to the child's drinking regime, offering him more to drink.

Overdose

Exceeding the recommended dose of Ambrobene does not have a toxic effect, but can cause diarrhea or nervous excitement. If you drink a lot of pills, this leads to vomiting, profuse saliva, low blood pressure, severe nausea. For treatment, you should immediately (within 1-2 hours after taking the tablets) induce vomiting and perform a gastric lavage.

Interaction with other drugs

If Ambrobene is prescribed along with drugs that inhibit the cough reflex, this will lead to stagnation of mucus in the bronchi.
If the patient receives Amoxicillin, Doxycycline, Erythromycin or Cefuroxime, then the appointment of Ambrobene will increase the concentration of such antibiotics in the sputum.

Terms of sale

To purchase Ambrobene tablets, you do not need to show a prescription from a doctor at the pharmacy. On average, the price of 20 tablets of this drug is 140-150 rubles.

Storage conditions and shelf life

To store Ambrobene, a dry place is required where the tablets cannot be reached by a small child. The optimum storage temperature is less than +25°C. From the date of issue, the drug is valid for 5 years.