Ursofalk suspension composition. Suspension Ursofalk: complete instructions for use for newborns, side effects, analogues. Influence on the ability to drive vehicles and moving mechanisms

Many children are born with pathologies. This is due to hereditary predisposition, peculiarities of intrauterine development and insufficient development of body systems. Physiological jaundice occurs in about 70% of newborns. The main symptom of the disease is a change in skin color. As a rule, this condition resolves without medical treatment within 10 days after birth. However, there are cases when a baby needs help to fight the disease. Most often, pediatricians prescribe Ursofalk for the treatment of jaundice.

Dosage form and composition of the drug

Ursofalk is a drug that belongs to the group of hepatoprotectors. The drug provides protection to the liver from the harmful effects of bilirubin. Available in the form of capsules and suspensions. Capsules must be swallowed completely, without chewing or dissolving in water, so this form of release is suitable for the treatment of children over 3 years of age.

For newborns and babies under the age of three, a suspension is prescribed. It is a thick liquid of homogeneous consistency, which has ductility. The suspension is sold in glass bottles of 250 ml. Each box comes with instructions for use and a measuring spoon.

The main active ingredient of Ursofalk is ursodeoxycholic acid. This substance is also part of the bile. Auxiliary components in the preparation:

pharmachologic effect

Ursofalk for newborns is used to treat physiological jaundice, to dissolve cholesterol gallstones and to protect the liver from various negative environmental factors. The drug has the following actions:

Instructions for use

Ursofalk is prescribed to newborns when signs of jaundice appear. The drug is prescribed by a pediatrician, taking into account the need for use, the development of the disease and the age of the baby. The doctor determines the required dosage and duration of treatment. You can not independently increase or decrease the rate of the drug and interrupt the course of therapy.

If symptoms of adverse reactions or the development of allergies are found, it is necessary to consult a pediatrician about the possibility of further use of the drug.

Ursofalk against jaundice

After birth, the baby's body needs to improve the functioning of the respiratory system. In the process of intrauterine development, fetal cells received oxygen from the mother using a special protein - fetal hemoglobin. Since the first breath, this substance is excreted from the body. Cells are saturated with other hemoglobin, which is responsible for supplying the body with oxygen throughout life. During the destruction of fetal hemoglobin, bilirubin is formed, which is excreted in the urine.

If this process in the baby's body is pathological, and the newborn's liver cannot cope with the amount of bilirubin, the pigment enters the bloodstream and accumulates in the tissues of the body. As a result, the following symptoms appear:

yellow color of the skin and eyeball;
lethargy;
convulsions.

In the first weeks of life, the baby's liver begins to produce glucuronic acid. It reacts with bilirubin, reduces its toxic effects and promotes rapid elimination. If the body cannot cope with the amount of bilirubin, the use of a photolamp is prescribed. Most often, treatment is prescribed in the maternity hospital and lasts about 2 weeks (for premature babies - at least 3 weeks). The photolamp can also be used after discharge, after consulting with the doctor.

Sunlight has a positive effect on the body. Under the influence of the sun, bilirubin in the upper layers of the skin turns into a soluble substance that is excreted from the body with waste products. The optimal time for sunbathing is no later than 11 o'clock in the afternoon, since at other hours the rays can harm the thin skin of a newborn.

If these measures do not help reduce symptoms, mandatory treatment with hepatoprotectors is prescribed, since with a significant increase in bilirubin, it enters the brain and causes cell destruction. The drug cleanses the liver of toxins and accelerates the formation of enzymes involved in the excretion of bilirubin.

In what other cases is Ursofalk appointed?

In addition to the treatment of jaundice, Ursofalk is also used in the treatment of other serious diseases:

When is the drug contraindicated?

Contraindications for use:

individual intolerance to individual components of the drug;
serious disorders in the liver;
cholecystitis in acute form;
cholangitis;
diseases of the bile ducts, gallbladder and intestines (bleeding, inflammation, blockage);
gallbladder dysfunction;
cholesterol stones with a high content of calcium.

When using several types of drugs together, their interaction must be taken into account. Ursofalk is taken with caution with the following drugs:

Smectite, Colestyramine - hydroxide and aluminum oxide, which are included in the composition, significantly reduce the effect of the anti-jaundice agent;
Cyclosporine - Ursofalk enhances the excretion of the drug;
Ciprofloxacin - the absorption of the drug is impaired.

Method of application and dosage

For the treatment of newborns and children under 3 years old, Ursofalk is used in the form of a suspension. It has a pleasant taste, so the kids are happy to take the medicine. The dosage depends on the age, weight of the baby and the degree of development of the disease. The average dose is not more than 10 mg of the drug per 1 kg of body weight. Dosage according to the instructions:

children from 3 to 5 kg - 0.5 ml 1 time per day (1/10 measuring spoon);
children from 5 to 8 kg - 1.25 ml 1 time per day (1/4 measuring spoon).

Shake the bottle before use as sediment may form at the bottom. It is allowed to pre-mix the suspension with breast milk.

You can give medicine to a child with a pipette or syringe without a needle, dripping the solution on the inside of the cheek. If the drug gets into the throat, the baby may choke or start a gag reflex due to irritation of the root of the tongue. The drug can be given before and after meals.

Ursofalk is taken 1 time per day at bedtime. This is due to the fact that the liver mainly works at night. In addition, at this time, the body is in a relaxed state, therefore it is most susceptible to the effects of the drug.

As a rule, the course of treatment lasts a week. Therapy can be extended if there is no improvement, or reduced if the symptoms have disappeared earlier, but after consulting a doctor.

Can the child experience adverse reactions?

Despite the wide therapeutic effect, the drug is easily tolerated by the child's body, does not cause the development of side effects. Most often, reactions can occur if the required dosage is not observed or the course of treatment is increased. Possible complications:

allergies in the form of skin rashes;
nausea, vomiting, diarrhea;
profuse regurgitation;
pain in the abdomen.

Ursofalk's analogues

Ursofalk has a high cost and a number of contraindications, therefore, in some cases, pediatricians prescribe other means, for example, Ursosan. Which of these remedies is best for the baby is decided by the doctor, who takes into account the individual characteristics of the child and the nature of the disease.

The following effective analogues can be distinguished:

Ursosan. Drug based on ursodeoxycholic acid. Available in the form of syrup and capsules. Eliminates cholesterol stones and removes bilirubin. The dosage of Ursosan depends on body weight, the average rate is 10-15 mg per 1 kg of weight. Causes adverse reactions in the form of rash, diarrhea, nausea.
Hofitol (more in the article:). A French remedy that has a choleretic effect, the main substance is an extract of the leaves of the field artichoke. The drug restores liver cells, reduces the amount of urea in the blood, promotes the normal metabolism of fats and cholesterol. It is used to treat various diseases of the liver and other organs.
Ukrliv. The Ukrainian analogue of Ursofalk is used to eliminate the symptoms of physiological jaundice in newborns and other liver diseases. The required rate is prescribed by the doctor depending on the body weight of the child.
Choludexan. Effective for cholesterol stones, gastritis with bile reflux and jaundice. Children can be given from the first months of life.
Flamin. Available in the form of granules for newborns and tablets for children over 12 years old. To prepare the suspension, it is necessary to dissolve the contents of the sachet in water. Used for hepatitis, cholecystitis and jaundice.

Composition and form of release

Capsules - 1 caps. ursodeoxycholic acid - 250 mg excipients: corn starch; silicon dioxide colloidal; magnesium stearate; titanium dioxide; gelatin; purified water; sodium lauryl sulfate in a blister 25 pcs.; in a box of 2 or 4 blisters; or in a blister 10 pcs.; in a box 1 blister. Suspension for oral administration - 5 ml ursodeoxycholic acid - 250 mg excipients: benzoic acid; purified water; xylitol; glycerol; MCC; propylene glycol; sodium citrate; sodium cyclamate; anhydrous citric acid; sodium chloride; lemon flavor (Givaudan PHL-134488) in 250 ml bottles; in a box 1 bottle, complete with a measuring spoon.

Indications for use

Uncomplicated cholelithiasis (dissolution of cholesterol gallstones in the gallbladder, if they cannot be removed by surgical or endoscopic methods), chronic opisthorchiasis, primary biliary cirrhosis of the liver, primary sclerosing cholangitis, chronic active hepatitis, chronic autoimmune hepatitis (atypical forms), non-alcoholic steatohepatitis, acute and chronic viral hepatitis, toxic liver damage (alcoholic, drug), atresia of the intrahepatic biliary tract, cholestasis with parenteral nutrition, biliary reflux esophagitis, biliary reflux gastritis, biliary dyskinesia, alcoholic hepatosis, acute hepatitis, chronic active hepatitis with cholestatic syndrome, pathology of the liver against the background of cystic fibrosis, congenital atresia of the bile duct, biliary dyspeptic syndrome (with cholecystopathy and biliary dyskinesia), cholestasis of newborns associated with total parenteral nutrition. Prevention of liver damage when using hormones onal contraceptives and cytostatics, prevention of gallstone formation in obese patients during rapid weight loss.

Contraindications for use

Hypersensitivity, X-ray positive (high Ca2+) gallstones, non-functioning gallbladder, biliary gastrointestinal fistula, chronic hepatitis, inflammatory diseases of the small and large intestine, acute cholecystitis, acute cholangitis, cirrhosis of the liver in the stage of decompensation, hepatic and / or renal insufficiency, pancreatitis, obstruction of the biliary tract, acute infectious diseases of the gallbladder and bile ducts, gallbladder empyema, pregnancy, lactation.

Use in pregnancy and children

Contraindicated during pregnancy and lactation. Children's age (appropriate studies of the cholelitholytic effect of UDHL on age in children have not been conducted).

drug interaction

Colestyramine, colestipol and antacids containing aluminum hydroxide or smectite (aluminum oxide) reduce the absorption of ursodeoxycholic acid in the intestine and thus reduce its effectiveness. If the use of preparations containing at least one of these substances is still necessary, they should be taken at least 2 hours before taking Ursofalk. Ursodeoxycholic acid may enhance the absorption of cyclosporine from the intestine. Therefore, in patients taking cyclosporine, the doctor should check the concentration of cyclosporine in the blood and, if necessary, adjust its dose. In some cases, Ursofalk may reduce the absorption of ciprofloxacin. Lipid-lowering drugs (especially clofibrate), estrogens, neomycin or progestins increase the saturation of bile with cholesterol and may reduce the ability of Ursofalk to dissolve cholesterol gallstones.

Dosage

Inside, without chewing, with food or a light snack, with cholelithiasis - 1 time before bedtime, with liver diseases - 2-3 times a day, 10 mg / kg / day (2-5 capsules), drinking plenty of water. For the prevention of recurrent cholelithiasis - 300 mg 2 times a day for several months after the dissolution of stones. For the treatment of biliary reflux gastritis and biliary reflux esophagitis - 250 mg at bedtime without chewing. The course of treatment is from 10-14 days to 6 months, if necessary - up to 2 years. Acute and chronic viral hepatitis, toxic liver damage (alcoholic, drug), primary biliary cirrhosis of the liver - 8-12 mg / kg / day. Cholelithiasis, chronic opisthorchiasis - 10-15 mg / kg / day. Primary sclerosing cholangitis - 12-15 mg / kg / day. Chronic autoimmune hepatitis (atypical forms), non-alcoholic steatohepatitis - 13-15 mg / kg / day. Cystic fibrosis - 20 mg / kg / day. Neonatal cholestasis - 30-40 mg / kg / day. Cholestasis of newborns associated with total parenteral nutrition - up to 45 mg / kg / day.

The use of Ursofalk is considered one of the effective procedures for the treatment and prevention of diseases of the liver and biliary tract.

In addition, this European drug is actively used in diseases of the large intestine and esophagus, it has a positive effect on slowing down the growth of malignant tumors.

Release form, composition and packaging

Ursofalk- the official international name of the drug. Available in 2 forms - capsules and suspensions.

Produced in Europe (manufacturing country - Germany), is intended for the treatment and improvement of the functioning of the liver, in some cases it can be used as a prophylactic.

The main active ingredient of Ursofalk is ursodeoxycholic acid.

Excipients for capsules and suspensions are slightly different.

For capsules:

starch;
magnesium;
titanium;
sodium;
gelatin;
colloids;
dioxides.

For suspension:

water;
flavors;
propylene glycol;
chlorides;
citrates;
xylitol;
glycerol;
citric and benzoic acids.

Capsules - in 1 blister - 10 pieces. They are sold in cardboard packaging - 6 or 10 pieces in 1 package.

The suspension is released in glass vials. They are darkened. In 1 vial - 250 ml of the drug. Each box contains a plastic measuring cup and detailed instructions on how to use Ursofalk.

pharmachologic effect

The use of the drug for treatment has a positive effect:

Reduces the level of toxic elements in bile, reduces the stagnation of some components of bile. Influences the normalization of liver tissues and ducts.
Ursofalk has an effect on the strengthening of membrane cells, which allows you to protect, stabilize and normalize the capabilities of cells.
Acts as an immunomodulator.
Reduces the amount of absorption of cholesterol in the body, promotes its rapid removal from the body.

The use of Ursofalk has a positive effect on the processes in the body, strengthens the cells of organs and tissues.

Ursofalk is not an antibiotic. Able to normalize the level of bilirubin in the body. This allows it to be used even by newborns.

Features of dynamics and kinetics

The absorption of the drug takes place in the large intestine. The absorption is very fast.

Metabolic processes involving this drug occur in the liver and intestines. Half-life occurs on average in 4 days. The output occurs along with feces.

Ursofalk has a characteristic cumulative effect, therefore, in order to completely remove it from the body, you must not take it.

Indications for use

Most often, the drug is used as a drug for disorders of the gallbladder and liver. Often they are accompanied by impaired bile flow, elevated cholesterol levels, and impaired liver function.

Contraindications for use

Hypersensitivity or intolerance by the body to any component of Ursofalk.
In acute inflammatory processes of the bile ducts, obstruction of the bile ducts.
Cholecystitis, biliary colic.
Calcified gallstones.

Instructions for use

Ursofalk is made in Germany. It is used to treat diseases of the bile ducts and liver. The main active ingredient is ursodeoxycholic acid.

Method of application and dosage regimen

Ursofalk is taken orally. The number of appointments is determined by the attending physician. If 1 dose per day - it is desirable that it be in the evening.

Capsules are washed down with clean water without gas, they can not be chewed. The suspension is mainly used for young children.

Scheme and course of treatment

The course of treatment depends on the disease and the physiological characteristics of the person. The maximum course of treatment with a drug that can be prescribed is 1 year.

Scheme and course of treatment depending on the disease:

You need to know that the daily rate of the main active ingredient of the drug is 10 mg per 1 kg of body weight.

Calculation of dosage depending on body weight

There is no single regimen or dosage for the treatment of Ursofalk. In most cases, how to apply the medicine depends on the neglect of the disease and the body weight of the patient.

Capsule intake:

up to 60 kg - 2 caps.
60-85 kg - 3 caps.
85-105 kg - 4 caps.
over 105 kg - 5 caps.

Suspension intake:

5-12 kg - 1.25-2.5 ml.
13-25 kg - 3.75-5 ml.
26-50 kg - 7.5-10 ml.
51-80 kg - 12.50-15 ml.
81-100 kg - 20-25 ml.

Side effects

In some patients, the use of Ursofalk can provoke side effects:

Overdose

It is possible to change bowel movements. If diarrhea or loose stools do not go away for several days, you should stop using Ursofalk. Stop diarrhea by maintaining fluid and electrolyte balance in the body.

Cases of drug overdose are almost impossible.

Use during pregnancy and breastfeeding

There have been limited studies on the use of the drug in pregnant women or during the feeding of infants.

Only a doctor can prescribe this medicine, taking into account all the risk factors that the fetus and woman are exposed to when using Ursofalk.

During the period of treatment with Ursofalk, it is better not to plan a pregnancy. The use of reliable contraceptive methods is recommended.

Data on the penetration of the main active substance into breast milk are not available. That's why simultaneous treatment with the drug and breastfeeding of the baby is prohibited. If the use of Ursofalk is simply necessary, the child should be weaned.

Application for newborns with jaundice

Many newborns suffer from jaundice after birth.

It can be determined only after the child has been tested for bilirubin.

Its significant increase leads to jaundice.

To protect the liver of a newborn and remove such toxins faster, special medications are needed that normalize the excretion of bile from a small body.

One of these drugs is Ursofalk.

It helps to strengthen the liver, performs a protective function for the liver, quickly processes bilirubin and promotes its release.

How to apply?

Newborns are prescribed only suspensions. The dose is prescribed by a pediatrician or neonatologist. But on average it is 10 mg per 1 kg.

Like adults, such children should be given medicine in the evening. Do not risk the life and health of the baby and self-medicate.

Interaction with other drugs

If the patient uses other medicines in parallel with Ursofalk, this should definitely be told to the doctor.

With the interaction of Ursofalk and certain drugs, it is possible to reduce the effectiveness of one of the drugs:

Alcohol compatibility

Ursofalk is allowed to be used to restore liver function and remove toxins from the body (including alcohol). In order not to aggravate the situation, the simultaneous use of medication and alcohol is strictly prohibited.

Otherwise, poisons (alcoholic toxins) will continue to accumulate in the body and even the drug will not have time to remove them.

Use in the elderly

It is allowed to use Ursofalk as a drug for the elderly. This requires a mandatory consultation of specialists (especially if the patient is taking other drugs in parallel).

For impaired liver function

The drug is prohibited for use in case of serious (pronounced) changes in liver function.

In case of impaired renal function

The drug should not be used for serious (pronounced) changes in kidney function.

special instructions

Before starting treatment, pay attention to the features of the use of the drug:

Terms of dispensing from pharmacies

A prescription is not needed to purchase the drug.

Storage conditions and shelf life

Does not require special temperature storage conditions. Ursofalk should be in a place that is difficult to reach for children and animals. The preparation should not be exposed to direct sunlight.

From the date of manufacture, store the drug for no more than 5 years (tablets and suspension - not printed).

Price

The average price in Russian pharmacies depends on the form of release:

Capsules: 1800 rubles. The price is for 100 capsules, dosage 250 mg.
Suspension: 1150 rubles.

Analogues

Consider Ursofalk's analogues in more detail:

. Treatment and prevention of chronic liver diseases. It is used for liver damage after chemotherapy, radiation, alcoholic liver damage. Available in tablets. The country of origin is India. Children under 6 years of age are not recommended to take the drug. Average cost - 360 rubles. The price is for 100 tablets.
Livodex. Available in tablets. Pack of 50 and 100 pieces. Its properties are proven: choleretic, normalization of cholesterol in the body, immunostimulating. It is prescribed for biliary cirrhosis, in the presence of small or medium-sized stones of cholesterol origin, with biliary reflux gastritis. The average course of therapy is 6-12 months. Price - 820 rubles. The price is for 100 tablets.
. It is prescribed for liver pathologies and liver damage with radiation, psoriasis, neurodermatitis, with an increased amount of cholesterol in the blood. The average daily intake is 6 capsules, divided into 3 doses. Cases of side effects and drug overdose are very rare. Price - 1250 rubles. The price is for 100 capsules.
. Available in capsules. It is used for violations of the liver, hepatitis of various origins, cirrhosis of the liver, psoriasis, before or after surgery on the biliary tract or liver. It has a minimum number of contraindications. Price - 670 rubles. The price is for 30 capsules.
. The active ingredient is silymarin. It is used for toxic liver damage, inflammatory liver diseases or cirrhosis. May be used for children over 5 years of age. The average dose per day is 3-6 tablets, divided into 3 doses. The dose can only be increased by a specialist. There are no studies that would talk about the negative effect of interactions with other drugs. Price - 360 rubles. The price is for 30 capsules.
. The main active ingredient is ademetionine. Available in powder form for solution for injection. Indicated for use in liver cholestasis, chronic hepatitis and cirrhosis of the liver, depressive syndromes. The dosage and scheme of application depends on the patient's condition and diagnosis. Price - 1860 rubles(for 5 vials) 2110 rubles(for 20 tablets).
Ursodez. It is prescribed for hepatitis of various origins, cholangitis, cystic fibrosis, for the removal of alcoholic toxins, for biliary dyskinesia. Price - 520 rubles for 40 capsules.
Essliver. Available in capsules. Application - with fatty degeneration of the liver, hepatitis of various origins, cirrhosis of the liver, before or after surgery on the liver, with psoriasis and toxic liver damage. Not applicable to the treatment of children under 12 years of age. Price - 430 rubles. The price is for 50 capsules.
Urolesan. The medicine is used in urology for the treatment of diseases of the urethra and kidneys, with chronic cholecystitis, cholelithiasis. The drug is rapidly absorbed and begins its action within 25 minutes after ingestion. Excreted by the kidneys and through the digestive tract. Cost - 355 rubles (drops, 25 ml), 390 rubles (capsules - 40 pcs).
. The main active ingredient is phospholipids. It is indicated for use in various forms of hepatitis, cirrhosis of the liver and liver damage by toxins. The capsules are taken orally. The exact dose of the drug is indicated by the doctor. Do not take the remedy for more than 6 months without a break. Price - 530 rubles. The price is for 50 capsules. The cost of 5 vials for the preparation of injections - chronic, colitis, flatulence, gastritis, severe diarrhea of non-infectious genesis. Can be used for frequent indigestion. The average daily dose is 1-3 tablets. Price - 240 rubles. The price is for 50 tablets.

Which is better: Ursofalk or Ursoliv?

The main substance in these drugs is similar - ursodeoxycholic acid.

According to patients, there was no significant difference after using the drugs. Doctors say that Ursofalk has a better and more natural composition of excipients.

Some patients claim that Ursoliv begins to act faster and the effect is more noticeable. Basically, the speed of action depends on the physiological characteristics of the organism.

The price of Ursofalk and Ursoliv is significantly different. The latter costs mainly 1.5-2 times cheaper.

To choose a more effective medicine for yourself, you need to take into account the characteristics of each individual disease.

Ursofalk is a drug used to treat diseases associated with the destructive work of the gallbladder and liver. It is available in different variations and has positive and negative properties. Therefore, it is better to study the characteristics of the tool in more detail.

In pharmacies, Ursofalk is released as a suspension / capsule with powder inside. In the first case, the volume of the substance in a closed pack is 250 ml, which corresponds to 50 single doses of 250 mg of the active ingredient for every 5 ml of liquid (volume of a measuring spoon).

The capsule formulation is sold in 3 versions:

50 pcs. in 2 blisters;
100 pieces. in 4 blisters;
10 pieces.

The components of the medicinal product (PM):

Medicine is packed into a dense cardboard box. The package indicates the type of medicinal supply, volume, the manufacturer's annotation is enclosed inside. The suspension set includes a measuring spoon.

What is it used for

The tool has certain indications. These include:

biliary reflux gastritis;
biliary cirrhosis of the liver of the primary stages without decompensation manifestations (treatment according to symptoms);
the presence of cholesterol stones in the gallbladder (the remedy helps to soften and dissolve them);
hepatitis of the chronic stage, of various genesis;
cystic fibrosis (cystic fibrosis);
sclerosing cholangitis (primary stage);
liver dysfunction of an alcoholic nature;
non-alcoholic steatohepatitis;
dyskinesia of the bile ducts.

In the presence of other health problems, restrictions on the prescription of the drug are possible. In such cases, its use should be coordinated with the supervising physician.

pharmachologic effect

When ingested, ursodeoxycholic acid (UDCA) accumulates by passive diffusion on the walls of the small intestine. At the same time, the content of the substance in the blood increases.

During the therapeutic course, UDCA replaces the main acids of bile entering the blood (48%). With a daily intake of 10-20 mg/kg, UDCA replaces up to 75% of the acid composition of bile. Altered bile is involved in digestive and immune processes; in women it crosses the placenta. The greater the content of UDCA in the bile fluid, the more pronounced effect it gives.

The active substance Ursofalk has a membrane-stabilizing effect: direct cytoprotection is carried out on the membrane of cholangiocytes / hepatocytes. At the stages of its accumulation and entry into the natural intestinal processes, hydrophobic acids, probable toxins, are gradually replaced.

In the future, there is a deterioration in the intake of cholesterol by the intestines, the normalization of the microflora on the inner walls of the intestines and stomach. The natural process of rejection of toxins leading to cell death is launched.

This mechanism has positive side effects: inhibition of colon cancer cells, suppression of foci of inflammation on the intestinal walls.

Instructions for use

The main therapeutic substance (ursodeoxycholic acid) is allowed for use in all age categories. Due to the possibility of reducing a single dosage and a safe form of administration, a suspension is recommended for patients up to 36 months from birth (this applies to the weight category of patients up to 34 kg).

Method of use - oral. When removing cholesterol stones, portions of the medication are calculated based on weight. The optimal value is 10 mg / kg per day. For capsules, this corresponds to: 35-60 kg - 2 pcs., 61-80 kg - 3 pcs., 81-100 kg - 4 pcs., from 100 kg - 5 pcs. Scheme for calculating the daily dose of the suspension drug by weight of the patient:

Patient's weight, kg	Drug weight, mg	Suspension volume, ml	Number of measuring spoons, pcs.
5-7	62,5	1,25	0,25
8-12	125	2,5	0,5
13-18	187,5	3,75	0,75
19-25	250	5	1
26-34	375	7,5	1,5
35-50	500	10	2
51-65	625	12,5	2,5
66-80	750	15	3
81-100	1000	20	4
From 100	1250	25	5

Reception is made daily at bedtime with a small amount of water. If capsules are used, they are not chewed and swallowed whole. The course for removing stones is 6-12 months. In order to prevent recurrence, the medication is required to be used for another 2-3 months after recovery.

When diagnosing biliary reflux gastritis, Ursofalk is consumed daily in an amount of 250 mg. The average course is 0.3-6 months, in exceptional cases - 2 years. The elimination of symptoms of primary biliary cirrhosis must be approached carefully. The daily medicinal volume is calculated based on the weight of a person - for every 12-16 kg 250 mg of the medicinal substance.

At the initial stage of treatment (about 3 months), the daily intake of the drug is divided into several parts. If there is an improvement in the liver, it is reduced to one at bedtime. The remedy is used until complete recovery.

In some patients, when taking the drug at the initial stages of therapy, side effects may occur: itching, pain. Then the daily dose is reduced to 1 capsule / spoon, consumed in one evening dose. After the decline in the pronounced symptoms of the disease, the dosage and the number of daily doses gradually return to the required ones (5-7 days).

A list of other diseases, the daily calculation of Ursofalk and therapeutic periods are presented in the table:

Use for newborns

The treatment of infants must be approached carefully, in consultation with a doctor. Ursolfak's suspension is given with diluted water 1 time per day at bedtime. Medicinal share - 10 mg per 1 kg.

For convenience, you can use a medium syringe without playing: the drug is dosed with a measuring spoon and drawn in with a syringe, then purified water is drawn into it up to about 4 cm 3, after which the mixture is shaken, air is removed by pressing the piston, and the liquid composition is fed to the baby.

Application for jaundice

Jaundice suffers little: the average period of disease activity is from a week to 10 days. In this case, the symptoms disappear completely in 14 days. Treatment should be carried out by a pediatrician based on blood tests for bilirubin.

Self-medication is allowed, but only in the absence of the possibility of contacting a specialist. But if the symptoms of the disease do not go away after 2 weeks, the child must be taken to the hospital.

Contraindications and side effects

Ursofalk should not be used if a patient has X-ray positive stones in the gallbladder (with an excessive level of calcium in their composition), in case of failure / atrophy of the gallbladder, in case of inflammation in the areas of formation, flow of bile.

Additional factors for refusing the drug may be:

infectious, viral or other suppuration in the intestinal area;
decompensation stage of cirrhosis;
dysfunction of the kidneys, pancreas or liver with severe symptoms;
individual intolerance or atypical reaction of the patient's body to the components of the drug;
pregnancy in all trimesters;
lactation period.

Possible side effects: pain in the right hypochondrium or epigastric zone, increased liver transaminases, allergic manifestations in the form of rashes and itching, nausea, bouts of diarrhea. Also, the treatment of biliary cirrhosis of the primary stage may be accompanied by transient decompensation. At the end of the use of the remedy, the symptom disappears.

special instructions

In the fight against cholelithiasis, the effectiveness of therapy is controlled after six months by X-ray and ultrasound studies.

drug interaction

UDCA absorption, digestibility and effect are reduced due to concomitant use with Colestipol, Colestyramine or antacids. In order to avoid a decrease in the effectiveness of Ursofalk, these substances are taken with a gap of 2 hours or more.

Due to the likelihood of an increase in the absorption of Cyclosporine from the gastrointestinal system, its presence in the body is clarified through a blood test, and adjustments are made for admission. On an individual basis, the drug may inhibit (partially or completely) the absorption of Ciprofloxalin.

The use of lipid-lowering drugs (Clofibrate, etc.), Neomycin, estrogens or progestins increases the amount of cholesterol in bile, complicates the process of destruction of cholesterol seals under the influence of UDCA.

Analogues

Similar drugs based on UDCA are available on the market in a wide range. Substitutes for the drug in capsules / tablets:

Urso;
Livodex;
Urso 100;
Ursosan;
Ursor C;
Ursolit.

Substitutes are available in the form of a suspension:

Hofetol;
Heptor;
Pepopen;
Oveson;
Heptral.

Despite the similarity of the chemical composition, these drugs may differ in the concentration of the active substance, components and mechanism of action. Before using them, you need to study the attached instructions in detail or consult a doctor.

The price of the drug

The cost of Ursofalk depends on the manufacturer, the volume of the drug in the package and the point of sale. Its approximate cost in pharmacies of the Russian Federation:

Ursofalk (ursodeoxycholic acid) is a bile acid that reduces cholesterol in bile, which normalizes liver function. A product for newborns is available in the form of a suspension.

70% of babies show signs of jaundice in the first days after birth, since their liver does not work at full capacity, therefore, it cannot cope with the breakdown product of the hemoglobin transformed by the body - bilirubin.

Stools, urine change their color, the skin and whites of the eyes become yellow. If jaundice is not treated, then in a couple of weeks bilirubin will spread throughout the body, which will eventually provoke kernicterus and serious brain dysfunction.

Ursofalk is a European drug belonging to the group of hepatoprotectors. The medicine is intended not only for treatment, but also for protecting the liver and biliary tract from various negative factors.

The medicine effectively copes with numerous tasks:

It activates the functions of the liver, due to the enzymes responsible for the excretion of bilirubin, are actively produced.
Normalizes the outflow of bile, preventing its stagnation.
Reduces cholesterol levels in the blood, prevents the formation of kidney stones and gallstones, prevents the deposition of cholesterol plaques on the walls of blood vessels. Helps to remove bad cholesterol along with bile.
Strengthens the immune system.
Helps to improve the protective functions of a child's fragile body.
Improves the secretion of the pancreas and stomach.
Does not allow an increase in liver tissue.
It blocks the processes that provoke the expansion of veins inside the internal organs.
It has a detrimental effect on tumors, slowing down their growth.

The medicine Ursofalk not only helps to cure a newborn's jaundice, but also protects his fragile body from pathogenic microorganisms and internal organs from the effects of toxins.

Ursolfak is prescribed in such cases:

Ursofalk suspension for newborns contains the main component - ursodeoxycholic acid.

It has a wide spectrum of action and has a complex effect on the body:

protects liver cells from the negative effects of toxic enzymes;
has immunomodulatory properties by stimulating the growth of protective cells in the liver and intestines;
activates the liver, due to which bilirubin begins to be processed quickly and easily excreted from the baby's body;
reduces the load on the brain, preventing the transformation of jaundice into a severe form.

Among the additional components in the composition of Ursofalk are:

water;
glycerol is a substance often used to prepare infant formulas, as it is completely safe, it helps to dissolve all the components of the drug, guaranteeing a pleasant taste;
xylitol, a natural sugar substitute that has a choleretic effect;
microcrystalline cellulose, used as a thickener without changing the beneficial properties of the drug;
sodium chloride helps to make the consistency homogeneous;
benzoic acid is a preservative that allows you to save the beneficial properties of the suspension for a long time (4 years);
sodium citrate serves as a flavor enhancer;
propylene glycol is used as a diluent, odorless and tasteless;
flavors;
citric acid is used as an acidifier;
Sodium cyclamate is a sweetener that is not absorbed by the body and is easily excreted in the urine.

In what form is it issued

Today, a pharmaceutical company offers three forms of Ursofalk:

Pharmadynamics

The drug Ursofalk is absorbed in the small intestine, absorption occurs with an efficiency of up to 80%. The disintegration of the active component of the drug occurs in the liver, a small part in the intestine.

The active substance is excreted for 3-5 days along with feces. Partially, the agent accumulates in the body and is completely excreted from it only after stopping the intake.

Pharmacokinetics

Ursofalk is a hepatoprotector containing bile (ursodeoxycholic) acid. This substance helps to reduce cholesterol levels in bile mainly by dispersing the cholesterol and forming it into a liquid crystalline phase.

It has a positive effect on the enterohepatic circulation of bile salts, reducing the degree of reabsorption of toxic compounds in the intestine. Numerous studies have shown that bile acid has a directed hepatoprotective effect and reduces the toxicity of bile salts.

The main substance affects immunological reactions, reducing pathological aggression on the child's body, suppressing the production of cytokines and interleukins.

The active ingredient of the drug lowers the lithogenic index of bile, helping to increase bile acid in it. Partially or fully contributes to the dissolution of cholesterol and gallstones. It has choleretic properties.

Application

Ursofalk is a prescription drug, therefore it is impossible to prescribe a suspension for newborns and adults on their own. There is a standard dosage, but the doctor selects his dose and course for each patient, depending on the complexity of the disease.

For children under 18

Taking the medicine does not depend on food intake, but the time of administration is important. Most of the processes occurring in the liver fall at night, so the drug is given to infants 1 time per day at bedtime. The course is selected individually.

For children from one year to 18 years, the amount of the drug is also calculated by body weight:

8-12 kg - 2.5 ml;
13-18 kg - 3.75 ml;
19-25 kg - 5 ml;
26-35 kg - 7.5 ml;
36-50 kg - 10 ml;
51-65 kg - 12.5 ml;
66-80 kg - 15 ml.

If the drug is prescribed for the treatment of cholelithiasis, then it is necessary to undergo ultrasound and x-rays regularly to track the effect of taking the medication and prevent the development of calcification of stones.

In the first few months of therapy with Ursofalk, it is necessary to take tests every month that help to detect an increase in the activity of liver enzymes, and in the future, it is enough to take an analysis once a quarter.

For adults

For adult patients, the dosage of Ursofalk is also calculated according to body weight:

with a body weight of up to 60 kg, take up to 2 capsules per day;
weighing up to 80 kg up to 3 capsules;
with a weight of 80 and up to 100 kg up to 4 capsules per day;
over 100 kg daily dose is 5 capsules.

Take the entire dosage once at bedtime, while the capsules do not need to be chewed with a small amount of water.

The course of treatment, depending on the disease, can be from 6 months and last up to a year. If the remedy is used as a preventive measure to prevent recurrent cholelithiasis, then a second course begins after the stones have completely dissolved.

For pregnant

There is no exact data on how Ursofalk affects the fetus borne by a woman.

Patients who take a drug to dissolve gallstones are advised to additionally take effective non-hormonal contraceptives during the reception. You should also completely exclude the presence of pregnancy before starting therapy.

The active substance Ursofalk passes into breast milk in small quantities, therefore, during lactation, the drug can be taken without worrying about the development of unwanted manifestations in the baby.

For the elderly

For older people, the dosage is selected in accordance with body weight and health status. Each disease has its own course and dose:

The regimen is selected by the attending physician. The standard regimen is once at night, but in some cases the drug is prescribed to be taken 2-3 times a day, while the dosage increases in the evening. The diet does not affect the time of admission, you can take the medicine with meals, before and after.

Contraindications

Ursofalk suspension for newborns is prescribed only under the supervision of a pediatrician or neonotologist.

It is forbidden to prescribe medicine to children who have previously been diagnosed with such pathologies:

Overdose

If diarrhea is observed, then these are the first signs of an overdose of Ursofalk. Overdose occurs in rare cases, since the absorption of the main component decreases with increasing dose and most of it is excreted from the body with feces.

If diarrhea is observed, then it is necessary to reduce the dose, if the symptom does not disappear, then the drug is stopped. No special measures are required in this case, the effects of diarrhea are treated symptomatically, trying to maintain the balance of fluid and electrolytes.

Side effects

If you do not follow the dosage prescribed by the doctor and exceed the course of administration, then as a result, liver dysfunction may occur, which will be difficult to detect even for an experienced specialist. If you follow all the recommendations, then the medicine is well tolerated even by infants.

In rare cases, such undesirable manifestations may be observed:

At the first undesirable manifestations, you should seek help from a pediatrician who will reduce the dosage or select an analogue.

Combination with other means

Ursofalk suspension for newborns is not prescribed simultaneously with cholestyramine, antacids and colestipol. These drugs bind bile acid in the intestine and reduce the effect of the application. If one of the prescribed drugs contains a similar substance, then the drugs are taken with an interval of 2 hours.

The suspension may have an effect on the absorption of cyclosporine from the intestine. As a result of this feature, after taking cyclosporine, it is necessary to check its amount in the blood plasma and, if necessary, adjust the dosage. In some cases, the suspension is able to reduce the absorption of ciprofloxacin.

Some studies have shown that bile acid, which is part of Ursofalk, reduces the level of peak plasma concentration in healthy volunteers, so the results of the simultaneous use of the suspension with nifedipine should be observed. You may need to increase the dosage of nifedipine.

Estrogen hormones and drugs that lower cholesterol levels in the blood can greatly increase the secretion of cholesterol by the liver. As a result of this reaction, favorable conditions are created for the formation of stones in the gallbladder, which is ultimately considered the opposite effect of taking ursodeoxycholic acid, which is taken to dissolve them.

Terms and conditions of storage

You can store the drug in tablet form and in the form of a suspension for up to 4 years from the date of production. Ursofalk capsules can be stored for up to 5 years. It is necessary to store the product in any form in a dry, ventilated place where the temperature does not rise above +25°C. If you violate the storage conditions established by the manufacturer, this will significantly reduce the therapeutic effect.

An open vial of the suspension can be stored for no more than 4 months.

Terms of dispensing from pharmacies

Ursofalk suspension for newborns or capsules and tablets are sold in pharmacies without a prescription.

Analogues

If for some reason Ursofalk is not suitable, then it can be easily replaced with one of the analogues:

Ursofalk suspension is an effective treatment for liver diseases in newborns and adults. The medicine has a minimum of contraindications and undesirable manifestations, but a doctor must prescribe it and select the dosage, who will continue to monitor therapy and conduct all necessary studies.

Article formatting: Vladimir the Great

Video about Usofalk

Indications for taking Ursofalk: