Westcall tablets. Instructions for use vesticap, price, analogues, patient reviews. When is Vesticap applied?

Vesticap is a generic drug of betahistine (original drug Betaserc), manufactured by the Russian company Ozon. Belongs to the group of vertigolytics - drugs that improve blood circulation in the labyrinth. Vesticap is available in the form of blue capsules (depending on the dose, it varies from light blue to dark blue). The capsules contain a mixture of powder and granules. The active substance of the drug Vestikap, the dose produced by the company is from 8 to 24 mg. Excipients are lactose monohydrate, cellulose, starch, silicon dioxide and other substances. The capsule consists of gelatin, titanium dioxide, dyes.

Pharmacologically, Vesticap acts on histamine H1 and H3 receptors in the inner ear and vestibular nuclei. Due to its influence on histamine recipes, it improves microcirculation, normalizes endolymph pressure in the labyrinth. It also increases blood flow in the basilar artery. Enhances the recovery of vestibular function after the defeat of the vestibular function. In direct dependence on the dose, it reduces the call of action potentials in the nerve cells of the vestibular nuclei.

Pharmacokinetically quickly and completely absorbed from the gastrointestinal tract. It is excreted by 90% by the kidneys in the form of inactive metabolites. The half-life is approximately 3 hours.

Indications

Vesticap is indicated as a means of treating the syndrome and, as well as symptomatic therapy of various origins, including with.

Contraindications

There are few contraindications to the appointment of Vestikap, among them:

Pregnancy.
Breast-feeding.
Allergic reactions to the drug and components.
Children's age up to 18 years.
Lactose intolerance.

Caution should be used in asthma (risk of bronchial obstruction due to the effect on H-1 histamine receptors), with ulcerative lesions of the gastrointestinal tract, pheochromocytoma.

Dosages

It is taken orally during a meal. Dosages vary from 8 mg 2-3 times a day to 24 mg 2 times a day.

Improvement is noted 5-10 days after the start of treatment, a stable effect after a month of treatment. Therapy with Vesticap is usually long-term.

Overdose is rare, nausea, abdominal pain, drowsiness (at doses of about 500-600 mg), convulsions, damage to the cardiovascular system (when using doses above 600 mg) have been noted. There is no specific antidote, the symptoms quickly stop when the drug is discontinued.

Side effects

Side effects rarely develop. Among them, nausea, bloating, vomiting, abdominal pain, allergic reactions (more often skin) are most often noted.

special instructions

No cases of drug interactions have been described.. Antihistamines are theoretically able to reduce effectiveness.

Vesticap does not have a sedative effect and does not affect the ability to drive a car, does not reduce the speed of psychomotor reactions.

Storage conditions

Vesticap should be stored in a dry place, out of the reach of children, at room temperature. The shelf life is three years (less than that of drugs in tablet form due to the structure of the capsules).

Analogues

It is analog. All drugs of betahistine hydrochloride have a similar effect with the drug Vesticap.

Price

Vesticap is dispensed by prescription. Prices depend on the mark-up of specific pharmacies and pharmacy chains, as well as wholesalers. The average price for a Vesticap as of June 2017 is as follows:

Capsules 8 mg package No. 30 140-180 rubles.
Capsules 16 mg package No. 30 217-283 rubles, No. 60 245-335 rubles.
Capsules 24 mg package No. 30 317-411 rubles, No. 60 398-421 rubles.

Archival prices for June 2016: capsules with a dose of 8 mg, package No. 30 120-180 rubles, a dose of 16 mg, package No. 30 200-270 rubles, No. 60 260-355 rubles, a dose of 24 mg, package No. 30 280-370 rubles, No. 60 380-474 rubles. The dynamics of prices is multidirectional, over the past year a dose of 24 mg has become somewhat more expensive, but a dosage of 16 mg has become relatively more affordable, a dose of 8 mg without any particular dynamics. However, it is also worth noting the fact that often in the sale of packages of Vesticap No. 30 they are sold using a 1 + 1 promotion, which in some cases can compensate for price increases.

A drug that improves the microcirculation of the labyrinth, used in the pathology of the vestibular apparatus

Active substance

Betahistine dihydrochloride (betahistine)

Release form, composition and packaging

Capsules No. 0, body light blue, opaque, cap light blue, opaque; the contents of the capsules are a mixture of powder and granules of white or white with a creamy tint; it is allowed to compact the contents of the capsule in the form of a capsule, disintegrating when pressed.

Excipients: lactose monohydrate (milk sugar) 129 mg, microcrystalline cellulose 70.5 mg, potato starch 30 mg, copovidone 27 mg, sodium carboxymethyl starch 15 mg, colloidal silicon dioxide 1.5 mg, magnesium stearate 3 mg.

Capsule composition: cap - 0.0312%, titanium dioxide 4%, gelatin up to 100%; body - indigo carmine 0.0312%, titanium dioxide 4%, gelatin up to 100%.

10 pieces. - cellular contour packings (1) - packs of cardboard.
10 pieces. - cellular contour packings (2) - packs of cardboard.
10 pieces. - cellular contour packings (3) - packs of cardboard.
10 pieces. - cellular contour packings (4) - packs of cardboard.
10 pieces. - cellular contour packings (5) - packs of cardboard.
20 pcs. - cellular contour packings (1) - packs of cardboard.
20 pcs. - cellular contour packings (2) - packs of cardboard.
20 pcs. - cellular contour packings (3) - packs of cardboard.
20 pcs. - cellular contour packings (4) - packs of cardboard.
20 pcs. - cellular contour packings (5) - packs of cardboard.
30 pcs. - cellular contour packings (1) - packs of cardboard.
30 pcs. - cellular contour packings (2) - packs of cardboard.
30 pcs. - cellular contour packings (3) - packs of cardboard.
30 pcs. - cellular contour packings (4) - packs of cardboard.
30 pcs. - cellular contour packings (5) - packs of cardboard.
10 pieces. - polymer containers (1) - packs of cardboard.
20 pcs. - polymer containers (1) - packs of cardboard.
30 pcs. - polymer containers (1) - packs of cardboard.
40 pcs. - polymer containers (1) - packs of cardboard.
50 pcs. - polymer containers (1) - packs of cardboard.
100 pieces. - polymer containers (1) - packs of cardboard.

pharmachologic effect

An agonist of histamine H 1 receptors and an antagonist of H 3 receptors of the vestibular nuclei of the central nervous system. By relaxing the precapillary sphincters of the vessels of the inner ear, it improves blood circulation in the vascular strip of the inner ear.

Dose-dependently reduces the generation of action potentials in neurons of the lateral and medial vestibular nuclei.

Accelerates the recovery of vestibular function after unilateral vestibular neurectomy, accelerating and facilitating central vestibular compensation (due to antagonism with H 3 -histamine receptors).

Relieves symptoms of Meniere's syndrome and vestibular vertigo. A stable therapeutic effect occurs after 14 days.

Pharmacokinetics

Suction and distribution

After taking the drug, it is rapidly absorbed orally, plasma protein binding is less than 5%. The time to reach Cmax in plasma is 1 hour.

Metabolism and excretion

It is metabolized to inactive metabolites: 2-pyridylacetic acid (the main metabolite) and demethyl betahistine.

85-90% is excreted by the kidneys in the form of 2-pyridylacetic acid within 24 hours. Removal of betahistine and demethyl betahistine by the kidneys is insignificant. Through the intestines, only a small part of betahistine and its metabolites are excreted.

When taking the drug with food, C max betahistine is lower than when taken on an empty stomach. However, the total absorption of betahistine is the same in both cases, indicating that food intake only slows down the absorption of betahistine.

Indications

- treatment of Meniere's syndrome, characterized (accompanied by nausea and vomiting), hearing loss and tinnitus;

- symptomatic treatment of vestibular vertigo (vertigo).

Contraindications

- hypersensitivity to any of the components of the drug;

- pregnancy;

- lactation period;

- pheochromocytoma;

— children's age up to 18 years;

Overdose

Symptoms: nausea, abdominal pain, drowsiness (when taken at a dose of up to 640 mg); convulsions, cardiovascular complications (when taken at a dose of more than 640 mg or in combination with other drugs).

Treatment: symptomatic.

Vestikap: instructions for use and reviews

Vesticap is a histamine drug that improves the microcirculation of the labyrinth.

Release form and composition

Dosage form of Vestikap are capsules: gelatinous, with an opaque structure; No. 2 (8 mg capsules) - blue cap and light blue body; No. 2 (16 mg capsules) - blue cap and dark blue body; No. 0 (24 mg capsules) - light blue body and cap; inside the capsules there is a mixture of granules and powder of white with a creamy tint or white, it is possible to compact the contents of the capsule, which disintegrates when its shell is squeezed (8 mg or 16 mg: 30 or 10 pieces in a blister pack, in a carton box 10, 8 , 6, 5, 4, 3, 2 or 1 pack, 100, 50, 40, 30 or 10 pieces in a polymer container, in a cardboard bundle 1 container, 24 mg: 10, 20 or 30 pieces in a contour cell package, in a carton pack 1, 2, 3, 4 or 5 packs, 100, 50, 40, 30, 20 or 10 pieces in a polymer container, in a carton pack 1 container).

1 capsule contains:

active ingredient: betahistine dihydrochloride - 8 mg, 16 mg or 24 mg;
auxiliary components: potato starch, colloidal silicon dioxide, lactose monohydrate (milk sugar), copovidone, microcrystalline cellulose, magnesium stearate, sodium carboxymethyl starch;
composition of the capsule shell: gelatin, indigo carmine dye, titanium dioxide.

Additionally, as part of the capsule shell at a dose of 16 mg - azorubin dye.

Pharmacological properties

Pharmacodynamics

Betahistine affects mainly histamine H 1 and H 3 receptors localized in the vestibular nuclei of the central nervous system and the vessels of the inner ear, exerting a direct agonistic effect on them. The drug helps to improve microcirculation and capillary permeability, and also normalizes the endolymph pressure created in the cochlea and the labyrinth of the ear. At the same time, betahistine activates blood flow in the basilar artery and accelerates the regeneration of vestibular function after unilateral vestibular neurectomy, providing acceleration and facilitation of central vestibular compensation (through antagonism with H 3 -histamine receptors). The drug is characterized by a pronounced central effect, representing an inhibitor of H 3 receptors located in the nuclei of the vestibular nerve. It also weakens the generation of action potentials in the neurons of the medial and lateral vestibular nuclei, and this effect is dose-dependent.

Betahistine helps to alleviate the condition in patients with vestibular vertigo and Meniere's syndrome. A stable therapeutic effect is recorded 14 days after the start of therapy.

Pharmacokinetics

Betahistine is absorbed at a high rate, and it binds insignificantly to plasma proteins. The maximum concentration of the active substance of Vesticap in plasma is reached within 3 hours after administration. Betahistine is metabolized to form inactive metabolites: demethylbetahistine and 2-pyridylacetic acid, which is the main metabolite. From 85 to 90% of the dose taken is excreted in the urine as 2-pyridylacetic acid within 24 hours. Excretion of unchanged betahistine and demethylbetahistine through the kidneys is negligible. With feces, only a small part of betahistine and its metabolites are excreted.

Indications for use

symptomatic therapy of vertigo (vestibular dizziness);
Meniere's syndrome, characterized by tinnitus, hearing loss and dizziness, which is accompanied by nausea and vomiting.

Contraindications

age up to 18 years;
period of pregnancy;
breast-feeding;
pheochromocytoma;
lactase deficiency, glucose-galactose malabsorption syndrome, lactose intolerance;
individual intolerance to the components of the drug.

According to the instructions, Vesticap should be taken with caution in case of peptic ulcer of the stomach and / or duodenum (including history), bronchial asthma.

Instructions for use of Vestikap: method and dosage

Vesticap capsules are taken orally with meals.

The doctor prescribes the dose and duration of admission individually, by selection.

Usually, improvement is noted at the beginning of treatment, after two weeks of taking Vesticap, a stable therapeutic effect occurs. The course of therapy is long.

For elderly patients, dose adjustment is not required.

Side effects

from the digestive system: abdominal pain, nausea, bloating, vomiting;
from the nervous system: headache;
dermatological reactions: angioedema, pruritus, rash, urticaria;
allergic reactions: hypersensitivity reactions (including anaphylactic).

Overdose

An overdose of Vesticap is manifested by such symptoms as cardiovascular complications (when taking betahistine at a dose of more than 640 mg or in combination with other drugs), abdominal pain, drowsiness (when taken at a dose not exceeding 640 mg), convulsions. In this case, symptomatic therapy is prescribed.

special instructions

Patients with bronchial asthma, stomach ulcers and / or duodenal ulcers should undergo regular medical examination during the treatment period.

The clinical effect of the drug can increase gradually, in some cases it was several months after the start of the capsules.

Vesticap does not affect the ability to drive vehicles.

Use during lactation pregnancy

Vesticap is contraindicated during pregnancy and during breastfeeding.

Application in childhood

In pediatrics, Vesticap is not used.

drug interaction

The combination of betahistine with histamine H 1 receptor blockers could theoretically affect the effectiveness of one of these drugs.

Analogues

The analogues of Vestikap are: Betahistine, Alfaserk, Asniton, Vertex, Vasoserk, Betaserk, Betaver, Tagista.

Terms and conditions of storage

Keep away from children.

Store at temperatures up to 25 ° C in a dry, dark place.

Shelf life - 3 years.

Dizziness and tinnitus are caused by constriction of the capillaries. To cope with this problem, it is necessary to establish blood flow, restoring microcirculation and capillary permeability in the ear. The drug Vestikap helps relieve unpleasant symptoms.

Today we will consider Vesticap 24 mg, its cheap analogues and their comparison, instructions for use, prices and reviews.

Composition and properties

The fundamental chemical compound of the drug betahistine dihydrochloride is a synthesized analogue of the bioactive component of histamine.

Complement it: lactose, magnesium stearate, starch, sodium carboxymethyl starch (sodium salt from starch), gelatin, copovidone (binds toxins), food coloring.

The drug causes the activation of the transport of biological fluids of the capillaries of the inner ear and their permeability, acts directly. It has a powerful effect on the central nervous system, stabilizing its work and activating blood circulation.

Normalizes the pressure of the fluid that fills the ear cavity (endolymph), which is involved in the conduction of sound. Quickly eliminates ringing sensation in the ears and symptoms of vestibular vertigo, helps to restore hearing. Does not cause suppression of consciousness and drowsiness.

Vesticap is maximally absorbed into the blood after an hour if taken on an empty stomach. On a full stomach, this time increases three times. 90% of the drug is excreted by the kidneys, the rest by the liver and intestines. The removal process takes about a day.

Indications and contraindications

Vesticap is appointed:

Meniere's syndrome (a disease of the inner ear caused by an increase in fluid pressure - endolymph);
virtigo (vestibular dizziness) and the nausea that accompanies it.

Not assigned:

in childhood;
women during pregnancy;
people with lactose intolerance and other components of the drug.

Release form and dosage

The release of the drug is carried out in encapsulated form. Capsules of two types: 8 or 16 mg of the substance betahistine dihydrochloride.

You should drink 1-2 capsules three times a day with meals.

Vesticap is not compatible with alcoholic beverages!

Peculiarities

During treatment with possible side effects from the digestive system: difficult and painful digestion, feeling of nausea, vomiting, loose stools or constipation.

Allergic reactions from the epidermis and Quincke's edema are not excluded. The same symptoms may occur with an excessively large dose of the drug.

With caution, the drug is prescribed to people suffering from bronchial asthma, ulcerative lesions of the duodenum and stomach.

Vesticap is produced by the Russian LLC Ozon, the average price is 286 rubles.

Analogues

All medicines discussed below are synonyms for Vesticap, have identical composition and indications for use. They differ in the form of release, dosage, manufacturer and price.

The main difference from the original is that all analogues, excluding Betaserc, are contraindicated in bronchial asthma and stomach ulcers.

The table shows analogues of drugs that are more expensive and cheaper than Vestikap

Name	Release form	Dosage	Manufacturer	Price
Betahistine	whitish tablets with a mark indicating the dosage of the drug 8, 16 or 24 mg	applied three times a day, 8-16 mg with meals. Maximum per day - no more than 48 mg	CJSC "Pharmaceutical Enterprise "OBOLENSKOE" (Russia)	120 rub.
Tagista	tablet form of 8, 16, 24 mg	dosed at 8 mg - three times a day, 1-2 pcs., 16 mg - three times ½-1 pc., 24 mg - twice 1 pc.	MAKIZ-PHARMA LLC (Russia)	90 rub.
Betaserc	white, numbered tablets "256" for 8 mg, "267" and "289" for 16 and 24 mg, respectively	daily dose for adults - from 24 mg to 48 mg, divided into 2-4 doses	Solvay Pharmaceuticals (Netherlands), Abbott Healthcare SAS (France)	680 rub.
asneton	tablet form of 8 or 16 mg	8 mg: 1-2 pcs. at one time 3 times a day, 16 mg - ½-1 pc.	VERTEX JSC (Russia).	About 150 rubles.
Betaver	tablets	standard dosage as for the original	Veropharm (Russia)	280 rub.
Vazoserk	tablet form	standard dose	Abdi Ibrahim Ilac Sanayi ve Ticaret A.S.(Turkey)	No data
Vestibo	labeled tablets "B8" or "B16", respectively, the dose on the tablets of 24 mg is not labeled	a daily dose of 24 mg is recommended to be divided into 2-3 doses	Actavis Group h.f. (Iceland)	240 rub.
Microzer	tablet form	standard dose	Forme-nti, Italy.	130 rub.

Vesticap and its analogues are drugs that affect the central nervous system. Do not take the drug without first consulting a doctor!

The original drug and similar ones do not provide an instant effect, but provide for a long course of treatment. Most often, Veticap is prescribed in combination therapy with other drugs at the discretion of the attending physician. In the absence of effective treatment, the patient is assigned a full examination.

You can not combine these medicines with antihistamine (antiallergic) drugs, because the therapeutic effect will be suppressed.

In this article, you can read the instructions for using the drug Vesticap. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Vesticap in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Vesticap in the presence of existing structural analogues. Use for the treatment of Meniere's disease and tinnitus in adults, children, and during pregnancy and lactation.

Vesticap is a synthetic analogue of histamine. It acts like histamine, mainly on histamine H1 receptors. Causes expansion of precapillaries, in particular, facilitates microcirculation in the labyrinth. In addition, betahistine regulates endolymph pressure in the labyrinth and cochlea, leading to clinical improvement in vertigo of various etiologies. Reduces the frequency and intensity of dizziness, reduces tinnitus, improves hearing in cases of its decrease. Increases the tone of the smooth muscles of the bronchi, gastrointestinal tract. May cause increased secretion of gastric juice.

Pharmacokinetics

After oral administration, betahistine dihydrochloride (the active ingredient in Vesticap) is rapidly and almost completely absorbed from the gastrointestinal tract. Almost completely excreted from the body with urine within 24 hours.

Indications

Meniere's disease;
syndromes characterized by dizziness, tinnitus and / or progressive hearing loss, incl. dropsy of the labyrinth of the inner ear;
vestibular and labyrinth disorders (including dizziness, noise and pain in the ears, headache, nausea, vomiting, hearing loss);
vestibular neuritis;
labyrinthitis;
benign positional dizziness (including after neurosurgical operations);
vertebrobasilar insufficiency;
post-traumatic encephalopathy;
atherosclerosis of cerebral vessels (as part of complex therapy).

Release form

Capsules 8 mg, 16 mg and 24 mg (tablet form does not exist).

Instructions for use and dosing regimen

A single dose is 8-16 mg, the frequency of administration is 3 times a day. Treatment is carried out for a long time.

Side effect

nausea;
feeling of heaviness in the epigastrium;
skin rash;
hives.

Contraindications

pheochromocytoma;
peptic ulcer of the stomach and duodenum in the acute phase;
bronchial asthma;
1 trimester of pregnancy;
hypersensitivity to betahistine.

Use during pregnancy and lactation

Use in children under 12 years of age

Caution should be used in children.

special instructions

It must be taken into account that the desired clinical effect is achieved after several months of treatment.

drug interaction

Antihistamines, when taken simultaneously, reduce the effect of betahistine.

Analogues of the drug Vestikap

Structural analogues for the active substance:

Asneton;
Betaver;
Betahistine;
Betahistine hydrochloride;
Betahistine dihydrochloride;
Betaserc;
Betacentrin;
Vasoserk;
Vestibo;
Denoise;
Microzer;
Tagist.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.