Does Motilium help with regurgitation in babies? Motilium for children: instructions for use for the digestive system Motilium for a child 4 years old dosage

Many adults have experienced the drug Motilium on themselves. Available a large number of positive reviews about the drug for unexpressed disorders of the gastrointestinal tract, such as: heartburn, heaviness in the upper abdomen and bloating. But how does this medicine work on young children? Our article will help parents deal with doubts.

Children are usually given Motilium in the form of a suspension.

Motilium stimulates the intestines, while also having an antiemetic effect.

Action

Active substance medicinal product Motilium - domperidone:

• stimulates mechanical work stomach;
• promotes faster emptying of the contents of the stomach into the duodenum and further into the small intestine;
• strengthens the action of the sphincter (closing muscle ring) between the stomach and esophagus, which prevents the contents of the stomach from re-entering the esophagus;
• promotes proper peristalsis of the gastrointestinal tract towards the rectum.

Thanks to the listed properties, Motilium has an antiemetic effect, eliminates nausea, bloating and pain in the upper abdomen.

The drug provides high efficiency in combating the symptoms of disruption of the gastrointestinal tract.

Properties

The active substance domperidone has an antiemetic effect.

When taken, its highest concentration in the blood is reached after 1 hour. The content in breast milk in a nursing woman will be 4 times less than in her blood. The substance does not accumulate in the body and is completely eliminated after 14-18 hours. It practically does not penetrate the brain.

Manufacturers and release form

Motilium is produced by companies:

• Janssen in countries: France, Belgium, Italy;
• Catalent in the UK.

Motilium is available as:

• suspensions in 100 ml vials with a dosing syringe (pipette) in a cardboard box;
• suspensions in 200 ml bottles complete with a 10 ml measuring cup in a cardboard box;
• lozenges - 10 mg, 10 or 30 pieces in a carton;
• film-coated tablets - 10 mg, 10 or 30 pieces in a carton.

For children under 7 years of age, Motilium is prescribed in the form of suspensions, children over 7 years old can also be given in tablet form.

Both suspension and tablets can be bought at pharmacies without a doctor's prescription.

Before using the drug, you should consult with your doctor.

Indications

Suspension Motilium is prescribed for children:

• to suppress;
• with belching, a feeling of bloating and heaviness of the upper third of the abdomen and heartburn;
• with nausea and as a result of traumatic brain injury, chemotherapy;
• with sluggish work of the stomach and intestines (atony and hypotension) with excessive formation of gases and;
• in some studies of the gastrointestinal tract, for more rapid elimination contrast agent.

Important! This drug taken only on doctor's orders.

If you need to take other medications, consult your doctor about interactions with Motilium.

Contraindications

Motilium is not prescribed:

• with individual intolerance to the drug;
• with gastrointestinal bleeding;
• with a mechanical obstruction in the gastrointestinal tract (tumor, foreign body, congenital pathologies structures of the intestine)
• in case of violation of the integrity of the intestinal walls;
• with a brain tumor in the pituitary gland and hypothalamus.

Mode of application

Motilium accept before meals for 15-30 minutes.

Shake the suspension before use.

The bottle is produced with protection against children: the cap is unscrewed as standard (counterclockwise), but when opening it, it must be pressed in at the same time.

The 100 ml bottle comes with a handy dosing syringe with graduations (in kilograms of weight). Draw up the suspension up to the mark corresponding to the weight of the child. The 200 ml bottle comes with a measuring cup.

According to the instructions, for children weighing up to 35 kg (this corresponds to the age of up to 10 years), it is preferable to give Motilium in the form of a suspension. However, children weighing more than 20 kg (7 years and older) are also prescribed in tablets.

Film-coated tablets are washed down with water.

Coated tablets are indicated for adults and children weighing over 35 kg.

Carefully remove the lozenges from the blister as they are fragile. These tablets dissolve easily with saliva and do not need to be taken with water.

Dosage

1 ml of Motilium suspension contains 1 mg active substance domperidone.

Children under 5 years of age are usually prescribed single dose 2.5 ml of suspension per 10 kg of body weight. The frequency of admission is 3 times a day and sometimes at bedtime additionally if the symptoms do not stop during the day. When vomiting, you can give a double dose: 5 ml of suspension per 10 kg of body weight (or 0.5 ml per 1 kg).

Children over 5 years of age are prescribed 10 ml 3 times a day, if necessary, 1 additional dose at night if nausea and other symptoms persist. When vomiting, 20 ml is prescribed 3-4 times a day.

With kidney and liver failure the dosage of the medicine must be adjusted by the doctor.

Important! For children under one year old, treatment with Motilium is possible only under medical supervision.

Side effects

Side effects when taking Motilium are rare. However, when individual features, exceeding the dosage and duration of administration can be:

• a slight increase or swelling of the mammary glands;
• in older girls menstrual cycle.

Important! If you experience any of these side effects, stop giving the drug and tell your doctor about it.

Overdose

With an overdose of Motilium side symptoms intensify.

In this case, let the child Activated carbon(7-10 tablets) and offer to drink plenty of water. Tell your doctor about your symptoms so that further treatment can be adjusted.

Analogues

Motilium generics (analogues for active ingredient domperidone) are:

• Domperidone - tablets, film-coated, 10 mg each (Russia);
• Motonium - tablets, film-coated, 10 mg each (Russia);
• Domperidone Geksal - tablets (Germany);
• Domperidone Teva - tablets (Hungary, Israel);
• Motilac - lozenges (Russia);

More cheap analogue Motilium - Motilak.

• Passazhiks - chewable tablets (Russia).

All analogues are available in the form of tablets, respectively, can be used in children from 7 years. Children under 7 years old can only use the original drug Motilium.

The average price for Motilium in different cities of Russia is 400 rubles (for tablets) and 670 rubles (for suspension).

The listed analogues are cheaper original drug- from 110 to 240 rubles.

Registration number- P N014062/01-270213
Tradename- MOTILIUM®
international generic name(INN)- domperidone.
chemical name- 5-chloro-1--4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one

Dosage form
Suspension for oral administration

Compound
Active substance (per 1 ml suspension): domperidone 1 mg.
Excipients (per 1 ml suspension): microcrystalline cellulose and carmellose sodium 12.0 mg, liquid non-crystallized sorbitol 70% 455.4 mg, methyl parahydroxybenzoate 1.8 mg, propyl parahydroxybenzoate 0.20 mg, sodium saccharinate 0.20 mg, polysorbate 20 0 10 mg, sodium hydroxide about 10 µg*, water up to 1.0 ml.
* From 0 to 30 mcg.

Description
Homogeneous white suspension

Pharmacotherapeutic group
Antiemetic - dopamine receptor blocker central.

ATX code- A03FA03

Pharmacological properties

Pharmacodynamics
Domperidone is a dopamine antagonist with antiemetic properties. Domperidone does not penetrate well through the blood-brain barrier (BBB). The use of domperidone is very rarely accompanied by extrapyramidal side effects, especially in adults, but domperidone stimulates the production of prolactin by the pituitary gland. Its antiemetic effect may be due to a combination of peripheral (gastrokinetic) action and antagonism to dopamine receptors in the chemoreceptor trigger zone located outside the BBB in the area postrema. Animal studies, as well as low concentrations of the drug found in the brain, indicate a predominantly peripheral effect of domperidone on dopamine receptors.
When administered orally in humans, domperidone increases lower esophageal sphincter pressure, improves antroduodenal motility, and accelerates gastric emptying. Domperidone has no effect on gastric secretion.
Pharmacokinetics
Domperidone is rapidly absorbed after oral administration on an empty stomach, the maximum plasma concentration (Cmax) is reached within 30-60 minutes. The low absolute oral bioavailability of domperidone (approximately 15%) is associated with extensive first-pass metabolism in the intestinal wall and liver.
Despite the fact that the bioavailability of domperidone in healthy people increases when taking the drug after meals, patients with complaints from the gastrointestinal tract (GIT) should take domperidone 15-30 minutes before meals. Decreased acidity gastric juice leads to a decrease in the absorption of domperidone. Oral bioavailability decreases with preliminary admission cimetidine and sodium bicarbonate. When taking the drug after a meal, it takes longer to achieve maximum absorption, and the area under the concentration-time curve (AUC) slightly increases.
When taken orally, domperidone does not accumulate and does not induce its own metabolism; the maximum plasma concentration of 21 ng / ml 90 minutes after 2 weeks of oral administration at a dose of 30 mg per day was almost the same as the maximum plasma concentration of 18 ng / ml after the first dose. Domperidone binds to plasma proteins by 91-93%. Animal distribution studies using the radiolabelled drug showed significant tissue distribution but low concentrations in the brain. small quantities The drug crosses the placenta in rats.
Domperidone undergoes rapid and extensive hepatic metabolism by hydroxylation and N-dealkylation. In vitro metabolic studies using diagnostic inhibitors have shown that the CYP3A4 isoenzyme is the main form of cytochrome P450 involved in the N-dealkylation of domperidone, while the CYP3A4, CYP1A2 and CYP2E1 isoenzymes are involved in the aromatic hydroxylation of domperidone. Excretion in urine and feces is 31% and 66% of the oral dose, respectively. The proportion of the drug excreted unchanged is small (10% in the feces and approximately 1% in the urine). The plasma half-life after a single oral dose is 7-9 hours in healthy individuals, but increases in patients with severe kidney failure. In such patients (serum creatinine level >6 mg/100 ml, i.e. >0.6 mmol/l), the half-life of domperidone increases from 7.4 to 20.8 hours, but plasma concentrations of the drug are lower than in people with normal kidney function. A small amount of unchanged drug (about 1%) is excreted by the kidneys.
In patients with impaired liver function medium degree severity (Pugh score 7-9, class B on the Child-Pugh scale) AUC and Cmax of domperidone are 2.9 and 1.5 times higher than in healthy people, respectively. The unbound fraction is increased by 25%, and the terminal half-life is increased from 15 to 23 hours. In patients with mild hepatic impairment, systemic exposure is slightly reduced compared to healthy individuals based on Cmax and AUC values, with no change in protein binding or terminal half-life. No data are available for patients with severe hepatic impairment. Pharmacokinetic data for children are not available.

Indications

1. A complex of dyspeptic symptoms, often associated with delayed gastric emptying, gastroesophageal reflex, esophagitis:
- a feeling of fullness in the epigastrium, early satiety, a feeling of bloating, pain in the upper abdomen;
- belching, flatulence;
- nausea, vomiting;
- heartburn, regurgitation of gastric contents or without it.
2. Nausea and vomiting of functional, organic, infectious origin caused by radiotherapy, drug therapy or a diet disorder. specific indication is nausea and vomiting caused by dopamine agonists when used in Parkinson's disease (such as L-dopa and bromocriptine).

Contraindications

Hypersensitivity to domperidone or any of the components of the drug;
- prolactin-secreting pituitary tumor (prolactinoma);
- simultaneous reception oral forms of ketoconazole, erythromycin or other strong inhibitors of the CYP3A4 isoenzyme that cause a prolongation of the QT interval, such as fluconazole, voriconazole, clarithromycin, amiodarone and telithromycin (see section "Interaction with other drugs");
- in cases where incentives motor function the stomach can be dangerous, for example, with gastrointestinal bleeding, mechanical obstruction or perforation;
- moderate or severe liver dysfunction.

Carefully

Impaired kidney function;
- violation of the rhythm and conduction of the heart, including prolongation of the QT interval, disorders electrolyte balance, congestive heart failure.

Use during pregnancy and lactation

There are insufficient data on the use of domperidone during pregnancy. To date, there is no evidence of an increased risk of malformations in humans. However, MOTILIUM® should only be used during pregnancy if its use is justified by the expected therapeutic benefit.
In women, the concentration of domperidone in breast milk is from 10 to 50% of the corresponding concentration and does not exceed 10 ng / ml. The total amount of domperidone excreted in breast milk- less than 7 micrograms per day when used as a maximum allowable doses domperidone. It is not known whether this level has a negative effect on newborns. In this regard, when using MOTILIUM during lactation, breastfeeding should be stopped.

Dosage and administration

It is recommended to take Motilium® before meals; if taken after meals, the absorption of domperidone slows down a little.
The duration of continuous use of the drug without a doctor's recommendation should not exceed 28 days.
10-20 ml 3-4 times a day. Maximum daily dose- 80 ml (80 mg).

0.25 - 0.5 mg per 1 kg of body weight 3-4 times a day. The maximum daily dose of domperidone is 2.4 mg/kg, but not more than 80 ml (80 mg).
To determine the dose, use the child's body weight scale "0 - 20 kg" on the syringe.
Use in patients with impaired renal function
Since the half-life of domperidone increases with severe renal impairment, with repeated use, the frequency of taking the drug Motilium® should be reduced to 1-2 times a day, depending on the severity of the violation, a dose reduction may also be required. With long-term therapy, regular examination of such patients should be carried out (see section "Special Instructions").
Use in patients with impaired liver function
Motilium® is contraindicated in moderate and severe liver dysfunction. For mild hepatic impairment, dose adjustment is not required.

INSTRUCTIONS FOR USE

Before use, mix the contents of the bottle, shaking gently to avoid foaming.
Fig.1 The suspension is supplied in a package protected from accidental opening by children. The bottle should be opened as follows:
- press down on the plastic cap of the vial while turning it counterclockwise;
- remove the unscrewed cover.

Fig.2 Place the syringe into the vial. While holding the bottom ring in place, lift the top ring up to the mark corresponding to your child's weight in kg.
Fig.3 Holding the lower ring, remove the filled syringe from the vial.

Empty the syringe. Close the vial. Rinse the syringe with water.

Side effect

Adverse reactions observed in ≥1% of patients taking Motilium®: depression, anxiety, decreased or no libido, headache, drowsiness, akathisia, dry mouth, diarrhea, rash, itching, gynecomastia / breast enlargement, mammary gland sensitivity, haberdashery, amenorrhea, pain in the mammary glands, menstrual irregularities, lactation disorders, asthenia.
Adverse reactions observed in<1% пациентов, принимавших Мотилиум®: гиперчувствительность, крапивница, набухание молочных желез, выделения из молочных желез.

The following undesirable effects were classified as follows: very common (≥10%), frequent (≥1%, but<10%), не частые (≥0,1%, но <1%), редкие (≥0,01%, но <0,1%) и очень редкие (<0,01 %), включая отдельные случаи.
Immune system disorders. Very rare: anaphylactic reactions, including anaphylactic shock.
Mental disorders. Very rarely: agitation, nervousness (mainly in newborns and children of the first year of life).
Nervous system disorders. Very rarely: extrapyramidal disorders, convulsions (mainly in newborns and children of the first year of life).
Disorders of the cardiovascular system. Very rare: QT prolongation, severe ventricular arrhythmias*, sudden coronary death*.
Skin and subcutaneous tissue disorders. Very rare: angioedema, urticaria.
Renal and urinary tract disorders. Very rare: urinary retention.
Laboratory and instrumental data. Very rarely: abnormal liver function tests, increased blood prolactin levels.

*Some epidemiological studies have shown that the use of domperidone may be associated with an increased risk of developing serious ventricular arrhythmias or sudden coronary death. The risk of these phenomena is more likely in patients over 60 years of age and in patients taking the drug in a daily dose of more than 30 mg. The use of domperidone at the lowest effective dose in adults and children is recommended.

Overdose

Symptoms
Overdose symptoms may include drowsiness, confusion and extrapyramidal reactions, especially in children.
Treatment
There is no specific antidote for domperidone. In case of overdose, gastric lavage and the use of activated charcoal are recommended. It is recommended to closely monitor the patient's condition and conduct maintenance therapy. Anticholinergics, drugs used to treat parkinsonism, or antihistamines may be effective when extrapyramidal reactions occur.

Interactions

Anticholinergic drugs can neutralize the action of MOTILIUM.
The oral bioavailability of MOTILIUM is reduced after prior administration of cimetidine or sodium bicarbonate. Antacids and antisecretory drugs should not be taken simultaneously with MOTILIUM, as they reduce its bioavailability after oral administration (see section "Special Instructions").
The main role in the metabolism of domperidone is played by the CYP3A4 isoenzyme. The results of in vitro studies and clinical experience show that the simultaneous use of drugs that significantly inhibit this isoenzyme can cause an increase in plasma concentrations of domperidone. Strong inhibitors of CYP3A4 include:
Azole antifungals such as fluconazole*, itraconazole, ketoconazole* and voriconazole*;
macrolide antibiotics, such as clarithromycin* and erythromycin*;
HIV protease inhibitors, eg amprenavir, atazanavir, fosamprenavir, indinavir, nelfinavir, ritonavir and saquinavir;
Calcium antagonists such as diltiazem and verapamil;
Amiodarone*;
Aprepitant;
Nefazodon.
(Drugs marked with an asterisk also prolong the QTc interval (see section "Contraindications")).
In a number of studies of pharmacokinetic and pharmacodynamic interactions of domperidone with oral ketoconazole and oral erythromycin in healthy volunteers, these drugs have been shown to significantly inhibit the primary metabolism of domperidone, carried out by the CYP3A4 isoenzyme.
With the simultaneous administration of 10 mg of domperidone 4 times a day and 200 mg of ketoconazole 2 times a day, there was an increase in the QTc interval by an average of 9.8 ms during the entire observation period, at some points the changes varied from 1.2 to 17.5 ms. With the simultaneous administration of 10 mg of domperidone 4 times a day and 500 mg of erythromycin 3 times a day, there was an increase in the QTc interval by an average of 9.9 ms during the entire observation period, at some points the changes varied from 1.6 to 14.3 ms. In each of these studies, the Cmax and AUC of domperidone were increased approximately three times (see section "Contraindications").
At present, it is not known what contribution to the change in the QTc interval is made by elevated plasma concentrations of domperidone.
In these studies, domperidone monotherapy (10 mg four times daily) prolonged the QTc interval by 1.6 msec (ketoconazole study) and 2.5 msec (erythromycin study), while ketoconazole monotherapy (200 mg twice daily) and monotherapy with erythromycin (500 mg three times a day) led to a prolongation of the QTc interval by 3.8 and 4.9 ms, respectively, during the entire observation period.
In another multiple dose study in healthy volunteers, no significant prolongation of the QTc interval was found during inpatient domperidone monotherapy (40 mg four times a day, total daily dose of 160 mg, which is 2 times the recommended maximum daily dose). At the same time, plasma concentrations of domperidone were similar to those in studies of the interaction of domperidone with other drugs.

Theoretically, since MOTILIUM® has a gastrokinetic effect, it could affect the absorption of concomitantly used oral drugs, in particular, drugs with prolonged release of the active substance, or enteric-coated drugs. However, the use of domperidone in patients receiving paracetamol or digoxin did not affect the level of these drugs in the blood.
MOTILIUM® can be taken simultaneously with:
neuroleptics, the action of which it does not enhance;
with dopaminergic receptor agonists (bromocriptine, L-dopa), since it inhibits their undesirable peripheral effects, such as digestive disorders, nausea and vomiting, without affecting their central effects.

special instructions

With the combined use of the drug Motilium® with antacids or antisecretory drugs, the latter should be taken after, and not before meals, i.e. they should not be taken concomitantly with Motilium®.
Motilium® oral suspension contains sorbitol and is not recommended for patients with sorbitol intolerance.
Use in children
Motilium® in rare cases may cause neurological side effects (see section "Side effects"). The risk of neurological side effects is higher in young children because metabolic functions and the blood-brain barrier are not fully developed in the first months of life. In this regard, you should very accurately calculate the dose of Motilium® for newborns, children of the first year of life and children of early preschool age and strictly adhere to this dose (see section "Method of application and doses"). Neurological adverse effects may be caused in children by an overdose of the drug, but other possible causes of such effects must be taken into account.
Use in kidney disease
Since the half-life of domperidone increases with severe renal dysfunction, with repeated use of Motilium®, the frequency of use should be reduced to 1-2 times a day, depending on the severity of renal dysfunction, and it may also be necessary to reduce the dose. With prolonged therapy, regular examination of such patients should be carried out.
Effects on the cardiovascular system
Some epidemiological studies have shown that the use of domperidone may be associated with an increased risk of serious ventricular arrhythmias or sudden coronary death (see section "Side effects"). The risk may be more likely in patients over 60 years of age and in patients taking the drug in daily doses of more than 30 mg. The use of domperidone at the lowest effective dose in adults and children is recommended.

If the medicinal product has become unusable or the expiration date has expired, do not throw it into wastewater and into the street! Place the medicine in a bag and put it in a trash can. These measures will help protect the environment!

Impact on ability to drive and operate machinery

MOTILIUM® has no or negligible effect on the ability to drive and operate machinery.

RELEASE FORM
Suspension for oral administration 1ml/ml. 100 ml in a dark glass bottle with a screw cap, protected from accidental opening by children and with a schematic representation of the opening of the bottle printed on it, are placed together with a dosing syringe and instructions for use in a cardboard box.

STORAGE CONDITIONS
Store at a temperature of 15 to 30 °C.
Keep out of the reach of children.

Best before date

It is not always possible for parents to protect their baby from situations when the digestion process is disturbed and the work of the gastrointestinal tract is confused. This manifests itself in the form of vomiting, regurgitation,. Similar problems are treated by Motilium suspension, which is a fast-acting and safe drug for children.

When is Motilium used?

Instructions for use indicate the following conditions in which Motilium is recommended:

• Heaviness in the abdomen;
• Severe pain in the intestines and stomach;
• Frequent belching;
• cyclic vomiting;
• Gas formation and;
• Inflammatory processes in the gastrointestinal tract, affecting the gastric mucosa and accompanied;

The drug is prescribed for dyspeptic manifestations associated with a slowdown in the progress of the food bolus along the gastrointestinal tract.

For children, Motilium is often prescribed for the development of food poisoning, to which babies are so susceptible, because the children's stomach often cannot cope with heavy food. The drug has a beneficial effect on the condition of the baby, if his body is exposed to infection, and causes nausea and vomiting.

Important! Motilium quickly eliminates unpleasant symptoms associated with disorders of the gastrointestinal tract, but is not able to eliminate the cause of the disease. Therefore, if the negative manifestations recur, you should consult a doctor.

Indications for use in infants:

• Appearance;
• Frequent regurgitation;
• Nausea and vomiting;
• Frequent and prolonged hiccups;
• Violation of the motor function of the stomach.

Digestive disorders can occur after a course of radiotherapy or chemotherapy, or be the consequences of an improperly balanced diet or diet. In this case, the drug is able to stop and prevent vomiting and minimize unpleasant symptoms. The drug blocks the central and peripheral receptors, thereby blocking the urge to vomit.

The suspension is more convenient to use for children under 5 years of age, but it can be used for children and older.

The safety of the suspension is due to its main active ingredient - doperidone, which is often added to preparations for children. The active ingredient is quickly absorbed into the intestines and stomach, stimulating their performance. Due to this, food is quickly excreted from the gastrointestinal tract, without irritating the mucous membrane.

Dosage and method of use

Motilium in the form of a suspension is intended mainly for oral administration to newborns and children under 5 years of age. In this case, the maximum single dose of the drug is calculated based on the weight of the baby: 2.5 ml for every 10 kg.

Important! The maximum daily dose should not exceed 80 ml or 2.4 ml per 1 kg of body weight.

How to take a newborn?

A newborn baby is prescribed a suspension to be taken three times a day about half an hour before meals. Within half an hour, the medicine begins to act. If the baby cries in the evening after taking the medicine three times a day, then his tummy is bothering him again.

In this case, you should also give the baby a suspension at night - this will improve the overall well-being of the baby, remove colic, improve gastrointestinal motility, which will allow the child to sleep soundly and calmly at night.

The suspension is given to the child for three days. If during this period the baby's condition has not improved, and the symptoms have not gone away, it may be necessary to regulate the doses of the medicine or replace it with analogues (in agreement with the pediatrician).

Suspension dosage:

• With swelling and manifestation of mild colic in newborns - 0.25 ml per kilogram of weight twice or thrice a day.
• With acute symptoms of the disorder in children under one year old - 0.5 ml per kilogram of the child's weight three to four times a day.
• For nausea and vomiting, children over 5 years of age - 500 mcg per kilogram of weight when unpleasant symptoms appear until they disappear completely.
• For digestive disorders, children over 12 years old (taking into account body weight over 35 kg) - 10-20 ml once 3-4 times a day.

If necessary, in severe cases, the dose can be doubled, but should not exceed 80 ml per day.

note ! Instructions for use are not a guide to action - the appropriateness of using the drug must be taken by the doctor.

Suspension application:

• Slightly press on the container lid from above, moving it clockwise;
• Remove cover;
• Pull out the pipette (it is attached to the bottle);
• Holding the lower ring in place, raise the upper one to the desired mark indicating the weight of the child;
• Carefully remove the pipette and give the medicine to the baby;
• Wash the pipette thoroughly after use.

Children over 5 years of age can be given medicine not from a pipette, but by pouring its contents into a regular spoon.

Contraindications to Motilium

Reviews about the use of the drug indicate a minimum of manifestations of adverse reactions with a high effectiveness of the action. However, in some cases, children experience side effects:

• Appetite disorders;
• intestinal disorders;
• Drowsiness;
• Headache;
• Disorders of the nervous system - children become excited and nervous;
• Allergic reactions.

An overdose of the suspension can give neurological disorders, infants may develop drowsiness, disorientation, and weakness. An overdose should not be treated independently - a specialist call is required.

• Individual intolerance to the components;
• Bleeding of the intestines and stomach;
• Mechanical obstruction;
• pituitary tumor;
• Liver dysfunction.

With caution and under the supervision of a doctor, medicine should be given to children with kidney problems, suffering from heart rhythm disturbances.

Do not combine taking the drug with drugs:

• amiodarone;
• Ketoconazole;
• Erythromycin;
• Fluconazole;
• Clarithromycin;
• Telithromycin.

Anticholinergic drugs block the action of Motilium, so they also cannot be used simultaneously with the suspension.

Analogues and reviews about the drug

You can buy from digestive disorders not only Motilium suspension, but also its analogues. Substitutes differ from the original in how much the drug costs and what its manufacturer is.

The average price for Motilium in suspension is 675 rubles. More cheaper you can buy analogues:

• Motilak - 165 rubles;
• Motizhekt - 191 rubles;
• Domrid - 107 rubles;
• Motinol - 194 rubles.

Reviews about the drug vary, because. mothers do not always use Motilium correctly, thereby not achieving the expected effect.

In use for newborns, the reviews of the suspension are overwhelmingly positive - parents note ease of use and a quick effect in relieving symptoms such as frequent regurgitation and bloating.

With vomiting, Motilium acts quite quickly - within 1-2 hours after taking the child, the child feels better. But to achieve the effect, some children need only one dose of the suspension, others need more time - it all depends on the age of the baby and his individual characteristics.

A symptom like nausea,- Not unusual. He can talk about the presence of a problem, but determining which one is not at all easy. This scares the parents. In such cases, the doctor often recommends that children take Motilium in the form of tablets or suspension (called syrup by parents), prescribing an individual dosage in accordance with the instructions for use.

Composition and form of release

Important! There is no effect of domperidone on gastric secretion.

Indications for use

Exists a number of indications for children to use Motilium. Basically, these are symptoms such as:

• nausea and
• belching;
• bloating;
• heaviness in the stomach.

Is it possible to give to children under one year old

Taking the drug is allowed immediately from the moment the baby is born, but you can not self-medicate. The doctor should especially carefully monitor such children while taking Motilium, as this can cause a neurological disorder.

Dosage and administration

When prescribing "Motilium" for children, the doctor takes into account the dosage recommended by the instructions, and the particular condition of the particular child. A single dose of suspension for children under 5 years of age is 2.5 mg per 10 kg of body weight. During the day, the reception is repeated three times. If the situation is very serious, it is allowed to take the drug four times a day. The last dose is given at night.

It is also necessary to give "Motilium" to a child during an exacerbation, as, for example, with vomiting, up to four times a day, but in a completely different dosage. A single dose should be 5 ml per 10 kg of the child's weight, as for children aged 5-10 years.

Important! The maximum permitted daily dose of the drug is 80 mg.

The medication is taken 15 minutes before. In addition to the suspension, the drug is also available in the form of tablets, but they can only be given to those children who whose weight exceeds 35 kg.

Contraindications and side effects

According to the instructions, there are certain contraindications for children's use of "Motilium":

• individual intolerance to the main component;
• sensitive response to
• changes in the processes of synthesis and absorption of glucose;
• obstruction of the digestive tract;
• bleeding in the stomach;
• liver disease, etc.

Side effects from taking the medicine- rare, but still happen. So, there may be problems with

Motilium- an antiemetic that can improve the motility of the digestive tract. The drug owes its properties to its active substance - domperidone. The action of Motilium stops vomiting, stimulates the digestive tract, accelerating the excretion of liquid, semi-liquid or solid fractions (when they stagnate).

Indications for use Motilium for children, as a rule, are caused by certain conditions accompanied by:

• vomiting, nausea (cyclic vomiting, gastrointestinal reflux);
• heartburn, belching (including regurgitation of newborns);
• bloating with excessive gas formation;
• heaviness in the stomach.

That is why in the treatment of dyspepsia in pediatrics, it is prescribed to take it. Indeed, in case of poisoning and similar conditions, the drug accelerates recovery, quickly and reliably restoring disturbed processes.

Motilium promotes fixation of the lower esophageal sphincter without changing the secretion of the stomach. Relief comes two days later from the start of the course of treatment.

Method of application and dosage

The regimen for taking the drug is covered in sufficient detail by the instructions for using Motilium. According to her, tablets are given to children only when their weight has already reached 35kg. Mostly in pediatric practice for the treatment of dyspeptic disorders use only suspension.

It is allowed to give children from birth, however, for the use of the drug in children under one year old, it is necessary control of the attending physician because there is a risk of neurological disorders.

Naturally, the dosage of Motilium should be prescribed by a doctor who will assess the condition of the child and his weight. Usually, for 10 kg of weight, it is prescribed to take 2.5 mg of the suspension three times a day.

When there is a need (in the stage of exacerbation), can be accepted fourth time the same dose at night. In general, acute conditions (for example, vomiting) require the appointment of 5 ml of suspension per 10 kg of weight up to 4 times a day. The maximum daily dose in this case can be 80 mg of the drug.

Motilium should be taken a quarter of an hour before meals due to its rapid absorption. It is worth paying attention that it does not combine well with other means. Therefore, you should tell your doctor about taking any medication.

Required Information

However, there are also Motilium contraindications, among them:

• individual intolerance to domperidone;
• sensitivity to lactose;
• changes in the synthesis and absorption of glucose;
• obstruction of the digestive tract;
• stomach bleeding etc.

Motilium is prescribed with caution to children, suffering from kidney and liver diseases.

Sometimes side effects of Motilium are also noted, which can develop into intestinal problems, spasms, allergies, neurological disorders.

At compliance with the rules for taking the drug, no overdose was noted, however, it is still worth knowing its signs. If you notice drowsiness, lethargy, or disorientation in your baby after taking Motilium, immediately stop the drug and give the child a sorbent (activated charcoal). Be sure to report the incident to your doctor.

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