Pancreatin indications for use instructions. Contraindications, side effects and overdose. Pancreatin: side effects

This drug has the same trade and generic - "Pancreatin". The drug is convex on both sides Pink colour interspersed, enteric-coated, with a specific odor. On the cross section of the tablets, two layers can be clearly seen.

The active ingredient of the drug is. Potato starch, calcium stearate, croscarmellose sodium, lactose monohydrate are used as auxiliary components. The composition of the shell includes the following substances: titanium dioxide, dye azorubine (acid red 2C), methacrylic acid, ethyl acrylate copolymer, talc, povidone, macrogol.

The action of the drug and indications for use

Enzymes included in Pancreatin break down proteins, starch and fats. Regular use of the drug improves the condition gastrointestinal tract, stabilizes the functions of the pancreas, contributes to the normalization of the digestive process.

"Pancreatin" is prescribed for malfunctions of the pancreas, with, as a replacement therapy. It is recommended to take the drug after irradiation, with gastrocardial syndrome (Remhelda), flatulence, cystic fibrosis, diarrhea. It is useful to take "Pancreatin" for violations of the absorption of food, people who abuse fatty, fried, spicy food, with irregular nutrition, as well as with a sedentary lifestyle and chewing disorders, when food is poorly chewed and hard to digest. The drug must be used before ultrasound bodies abdominal cavity and before x-ray examination.

Contraindications

The drug should not be taken when hypersensitivity organism to one or more of its components and during an exacerbation chronic pancreatitis. It is not recommended to take the drug younger than three years.

The greatest activity of the drug is observed 30-40 minutes after taking the tablets.

Dosage and administration

"Pancreatin" is taken with meals, washing down the tablets with a sufficient volume of water, without chewing.

Adults, in accordance with the instructions, are usually prescribed 2-4 tablets 3-4 times a day. For children, the drug is prescribed individually, depending on the severity of gastrointestinal diseases.

The duration of taking the drug is determined depending on the patient's well-being, usually it ranges from several weeks to several years. "Pancreatin" can also be used for a long period - up to several years: until the desired result is obtained.

Due to insufficient study of the effect of "Pancreatin" on the condition of the fetus, the drug is not recommended for use during pregnancy.

Side effects

Despite the good tolerability of the drug, when using it, there may be observed allergic reactions, diarrhea, constipation, discomfort , nausea. With prolonged use of "Pancreatin" in a very large doses ah, irritation of the oral mucosa is possible.

There are medicines, the effectiveness of which directly depends on compliance with the time of administration, set depending on life cycles human body, it is also necessary to consider compatibility with other medications taken. These drugs include Pancreatin.

Composition, principle of action

Pancreatin is an extract from the secretion of the pancreas of an animal (usually a pig) containing the following enzymes:

• lipase (breaks down fats);
• amylase (processes carbohydrates);
• protease (enzyme for proteins).

It is they who are responsible for ensuring that food is digested correctly and efficiently, providing a person with good health after eating.

The breakdown of proteins and carbohydrates is quite possible without the help of Pancreatin, but fats need it. Therefore, in diseases of the pancreas, the absorption of fatty foods is impaired, which leads to discomfort from the gastrointestinal tract in the form of heaviness, pain, and impaired bowel function.

However, due to diseases such as pancreatitis, cystic fibrosis, as well as various pathologies of the liver and gallbladder, the process of digesting food is disturbed. In such cases, it is possible as an adjuvant therapy in the treatment complex.

The drug is produced in the form of dragees, capsules or coated tablets, as under the influence gastric juice the enzymes will die. Entering the intestines active substances operate as follows:

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1. Break down dietary proteins into amino acids. Thus, preventing the development of putrefactive processes.
2. Fats are absorbed into the blood faster, taking part in metabolism.
3. Carbohydrates are broken down to the level of simple sugars, providing the body with energy.

Purpose

• Pancreatin is prescribed for various organ pathologies digestive system associated with the inhibition of enzyme activity, as well as a symptomatic remedy for nutritional errors.
• Against the background of inflammation of the pancreas (pancreatitis), the drug removes from it part of the load on the production of enzymes. The analgesic effect of Pancreatin is provided by its constituent trypsin, which suppresses the secretion of the gland.
  However, with an attack of pancreatitis, the drug should not be taken. In the acute phase of inflammation, part of the cells of the pancreas dies and pancreatic juice is released. If you add digestive enzymes at this point, you can significantly worsen the condition. Also, you can not drink Pancreatin with an exacerbation of hepatitis and with intestinal obstruction.
• After resection of a part of the stomach or intestines, as well as with colitis, Pancreatin helps to avoid complications in the form of undigested food. In violation of peristalsis and tone of the colon, enzymes stimulate motility, helping to get rid of stagnant masses.
• At chronic hepatitis and pathologies bile ducts Pancreatin is taken as replacement therapy, because in duodenum an insufficient amount of enzymes is supplied for cleavage. In such cases, treatment can last for months. If we are talking about correcting the consequences of malnutrition, then it is enough to take the drug for several days during or after meals.

At chronic gastritis pancreatin ensures timely digestion of food, preventing the appearance of toxic decay products, causing inflammation walls of the intestines and stomach.

Pancreatin is also prescribed for the following diseases:

• dyspepsia;
• violation digestive function due to chemotherapy;
• chronic liver diseases;
• Remheld's syndrome;
• after overeating.

There are not many side effects of Pancreatin:

• allergic reactions to dyes or other auxiliary components;
• diarrhea or constipation;
• fibrosing colopathy (intestinal obstruction) in patients with cystic fibrosis;
• nausea.

How to use

The required amount of additional enzymes is determined by the attending physician based on the patient's tests and depends on the degree of pancreatic insufficiency, as well as the quantity and quality of the food consumed.

Pancreatin packages indicate how many units active substance contained in one tablet or capsule. This will help you calculate the rate correctly.

• In some cases, the pancreas practically does not perform its functions of producing enzymes (cystic fibrosis), then the usual daily dosage of pancreatin can be increased as directed by a doctor.
• With the syndrome of pancreatic insufficiency, you need to drink tablets at the beginning of the main meal, as well as with snacks. Moreover, foods rich in fiber reduce the activity of enzymes. It is impossible to chew or otherwise violate the integrity of the tablet shell.
• It is correct to take the medicine during or immediately after a meal, and it is better to drink plain water, since some drinks, such as milk, destroy the acid-resistant shell of the drug, and its dissolution occurs much earlier.
• You can drink Pancreatin with juice (only not grapefruit), since juices and compotes from apples, prunes, berries have convertibility properties - when they enter the stomach during digestion, they exhibit an alkalizing effect
• If you drink Pancreatin before meals, then there will be a burning sensation and irritation of the stomach and intestines.
• You can take Pancreatin once as a preparation for x-ray, ultrasound or endoscopic methods examinations of the abdominal cavity, since the enzymes effectively reduce gas formation.
• You should not constantly take Pancreatin to relieve the condition after regular overeating. Similar eating behavior leads to weight gain and disorder of the digestive system, and the constant supply of enzymes from the outside will cause addiction and weaken the functions of the gastrointestinal tract.

Compatibility with other drugs and alcohol

It should be noted that Pancreatin disrupts the absorption of iron, so a decrease in hemoglobin is possible. With long courses of therapy, funds containing this element are additionally prescribed.

In some cases, even high doses enzyme preparations are not effective due to the increased acidity of gastric juice: lipase and trypsin are destroyed before reaching their destination. In such a situation, the doctor prescribes additional antacids or antisecretory agents, but if they contain calcium or magnesium, then enzyme activity is inhibited and the dosage is adjusted.

Ineffective at any dose will be treatment in cases of giardiasis or celiac disease.

The compatibility of Pancreatin with alcohol is undesirable, like any drug, although there have been no official studies on this subject. But you can take a pill once when overeating during a banquet, no health benefits negative consequences will not come. And if you regularly drink alcohol against the background of those diseases for which Pancreatin is prescribed, then this will undoubtedly lead to an extremely unpleasant outcome without pills.

Various factors can lead to inflammation of the gastric mucosa, among which the Helicobacter pylori bacterium is not the last. Influence it with antibacterial agents Therefore, antibiotics are sometimes prescribed to treat gastritis.
Propolis can also have a negative effect on the process of reproduction of bacteria, in particular, it inhibits and suppresses the process of reproduction of bacteria. Others noted positive properties, allowing the use of propolis for gastritis. Among them are:

• activation of the processes of regeneration of the gastric mucosa, which suffers from this disease;
• reduction of the inflammatory process;
• suppression of decay processes that can be observed in the gastrointestinal tract;
• restorative effect on the body.

Propolis should be used with caution, as with all bee products, due to its potential to cause an allergic reaction.

Therefore, before taking propolis or honey for complex treatment gastritis, you should consult your doctor to rule out possible side effects.

Recipes

On the basis of propolis, you can prepare a lot of healing compounds and some of them will be effective in diseases of the stomach. Therefore, we will consider in more detail the recipes that use propolis for gastritis.

Many of them can be roughly divided into three groups:

1. Means based on propolis and honey. The combination of honey with propolis is a strong healing agent, which is mainly aimed at increasing the body's defenses. It contains a considerable amount of vitamins, beneficial acids and minerals. For cooking remedy you will need to take 10 g of propolis and start heating it in a water bath. As soon as it melts, honey (200 g) should be added to it. This should be done slowly and constantly stir the composition. The resulting mixture should be heated to 60 degrees, after which it can be removed from the stove. accept this healing composition based on honey, one dessert spoon should be taken before meals. The course of treatment may take about 2 weeks.
2. Based on propolis and herbs. It is recommended to combine this beekeeping product for gastritis with hyperacidity. It is required to take in equal parts linden flowers, licorice root, fennel fruits and peppermint. Then 30 g is taken from the resulting mixture and poured with three glasses of boiling water. Then the resulting solution should boil over low heat for 20 minutes. Before use, everything should be infused for at least 3 hours, and then you need to add propolis with honey (3 tablespoons). Drink the finished product should be 100 ml every 2 hours. You can take it as a course (from 1 to 2 weeks).
3. Based on propolis and milk. This combination is not only effective, but also a delicious remedy to combat stomach inflammation, which can be drunk every day. To prepare it, you need to take one liter of milk and 50 g of propolis. Having connected these components, they should be put on a slow fire for heating. At the same time, it is important to constantly monitor the composition and stir so that the milk does not run away and does not burn. Heating over low heat continues for 10 minutes, after which the milk is removed from the stove and cooled. It is recommended to drink such a remedy before meals, 100 ml each (no more than 3-4 times a day). The general course of treatment, as a rule, lasts about 14 days.

As you can see, you can take propolis for inflammation of the stomach in various options, but in any case, before starting such treatment, it is better to consult a doctor.

Useful video about propolis

If you want to know what Pancreatin helps with and how to take it, then you should read our article about this drug. Pancreatin is an enzyme remedy that helps with diseases of the digestive system. The drug normalizes the processes of digestion and improves the condition of the gastrointestinal tract. Enzymes that are part of Pancreatin help break down fats in fatty acid and glycerol, proteins into amino acids, and starch into monosaccharides and dextrins. If there are malfunctions of the pancreas, then Pancreatin tablets make up for the deficiency of enzymes (lipase, trypsin, chymotrypsin and amylase) and compensate for its external secretory function. This medicine has an enteric coating, due to which it is not affected by the influence of gastric juice and begins to act directly in an alkaline environment small intestine. The highest concentration of enzymes of the drug is observed 30-40 minutes after the use of Pancreatin.

What is pancreatin used for?

- Diseases associated with exocrine pancreatic insufficiency:

• cystic fibrosis ( hereditary disease that affects the glands of external secretion and respiratory tract, and also having severe disorders of the functions of the gastrointestinal tract);
• chronic pancreatitis (inflammation of the pancreas);
• pancreatectomy (removal of the pancreas);
• dyspepsia.

- Flatulence (accumulation of gases in the intestines).
- Diarrhea (diarrhea).
- Condition after removal of part of the stomach or small intestine.
- Before ultrasonic and x-ray examination abdominal organs.
- Chronic inflammatory diseases stomach, liver, gallbladder and intestines.
- Failure in the patency of the pancreatic ducts or biliary tract.
Pancreatin tablets from which you can still use:
- Patients with normal function of the gastrointestinal tract with irregular meals or taking too fatty and spicy foods are prescribed this medicine to improve food digestion.
- With a sedentary lifestyle or prolonged immobilization.

Mode of application

Pancreatin tablets are taken orally with meals, drinking plenty of water. Dose medicinal product is established by the doctor individually, depending on the age of the patient and the degree of indigestion.

In most cases, adults are prescribed 2-4 tablets 3-6 times within 24 hours. No more than 16 tablets can be taken per day.

Children over 6 years of age usually take 1 tablet 3 times a day. It is better that the doctor selects the dose of the drug individually.

In cystic fibrosis, the dose of the drug is also selected individually. The dose of Pancreatin should be equivalent to the amount of enzymes needed for the absorption of fats, taking into account the quantity and quality of food consumed.

Contraindications

• hypersensitivity to the components of the drug;
• exacerbation of chronic pancreatitis;
• acute pancreatin.

Use during pregnancy and lactation

The effect of Pancreatin on the fetus during pregnancy has not been studied enough. Pancreatin tablets from which it is necessary to prescribe with caution, given the benefits for the mother and possible risk for the fetus. The components of the drug do not enter the mother's milk, therefore, during lactation, its use is allowed.

Side effects

• acute pancreatitis;
• allergic reactions;
• diarrhea (diarrhea);
• constipation;
• with too long use of the drug may develop hyperuricosuria (increased content uric acid in urine);
• when taking large doses with cystic fibrosis, strictures (narrowings) may form at the junction of the large and small intestines and in the large intestine;
• at high doses the use of Pancreatin by children may cause irritation of the oral mucosa.

Interaction

When using Pancreatin, there is a possibility of reduced absorption folic acid and iron.
Taking the drug together with agents that contain magnesium hydroxide or calcium carbonate in their composition is not desirable, as it can lead to a decrease in the therapeutic efficacy of Pancreatin.

Pancreatin is an enzyme that stimulates the liver and pancreas, improves digestion.

Improves the process of splitting proteins, fats and carbohydrates. Reduces the amount of gases in the intestines. Promotes absorption of fats and has choleretic action. Tablets are coated to protect them from gastric juice so that dissolution begins in small intestine. In pharmacies, the drug is sold freely, without a prescription.

In this article, we will consider why doctors prescribe Pancreatin, including instructions for use, analogues and prices for this drug in pharmacies. REAL REVIEWS people who have already used Pancreatin can be read in the comments.

Release form and composition

Pancreatin is available in the form of enteric-coated tablets (10 pcs in blisters, 2, 3 or 6 blisters in a carton box; 60 pcs in dark glass jars or polymer bottles, 1 jar or bottle in a carton box).

The composition of 1 tablet includes:

• Active substance: pancreatin - 25 or 30 IU (unit of action);
• Auxiliary components: lactose (milk sugar), gelatin, potato starch, calcium stearate, cellulose acetate (cellacephate), titanium dioxide (titanium dioxide), liquid paraffin ( Vaseline oil), polysorbate (tween-80), acid red 2C (azorubine dye).

What helps Pancreatin?

The use of the drug Pancreatin helps in the following situations and diseases:

1. Chronic inflammation of the pancreas;
2. Congenital or chronic insufficiency production of pancreatic enzymes;
3. Hereditary diseases of the digestive system;
4. Blockage of the excretory ducts of the pancreas;
5. Inflammatory diseases of the digestive system;
6. Rehabilitation therapy after removal of the pancreas;
7. Violation of the process of chewing food.

Pancreatin tablets also help to reduce the severity of symptoms accompanying enzyme deficiency: pain in the left hypochondrium and epigastrium after eating, bloating, nausea, loss of appetite, frequent stools.

pharmachologic effect

Pancreatin belongs to pharmacological group“Enzymes and antienzymes” and is a polyenzymatic drug, the action of which is aimed at replenishing the deficiency of pancreatic enzymes in the body and facilitating the digestion of protein, fatty and carbohydrate-containing foods entering the body. As a result, the latter are more quickly and more completely absorbed in the small intestine.

Instructions for use

In accordance with the instructions for the use of Pancreatin, this remedy intended for oral use only. Tablets are recommended to be taken with meals or immediately after the completion of the meal, while drinking plenty of water. The dose (in terms of lipase) depends on the age and degree of pancreatic insufficiency.

• The average dose for adults is 150,000 IU / day. With complete insufficiency of the exocrine function of the pancreas - 400,000 units / day, which corresponds to daily requirement adult human in lipase.
• Maximum daily dose is 15,000 U/kg.
• Children under the age of 1.5 years - 50,000 IU / day; older than 1.5 years - 100,000 IU / day.

The duration of treatment can vary from several days (in violation of the digestive process due to errors in the diet) to several months and even years (if necessary, constant replacement therapy).

Contraindications

Preparations Pancreatin forte, Lekt, 8,000 and 10,000 have the following contraindications for use:

• pancreatitis acute form and at the stage of exacerbation of chronic;
• intestinal obstruction;
• severe liver disease;
• individual intolerance to the components that make up the drug;
• children's age up to 3 years.

Side effects

The annotation states that the medicine "Pancreatin" is well tolerated by patients. Their reviews confirm given fact. In some situations side effects can still be observed. The medication may cause:

• diarrhea
• nausea;
• improper absorption of folic acid;
• discomfort in the abdomen;
• allergic reactions;
• constipation;
• perianal irritation.

Local reactions may develop against the background of hypersensitivity to the drug. With prolonged and excessive use, the development of hyperrucosuria or hyperuricemia is likely.

Pregnancy and lactation

The safety of pancreatin use during pregnancy has not been sufficiently studied. Application is possible in cases where the expected benefit to the mother outweighs the potential risk to the fetus.

In experimental studies, it was found that pancreatin does not have a teratogenic effect.

Analogues

Pancreatin analogues are Biozim, Zimet, Kreon, Licreaza, Mezim (Mezim Forte), Micrasim, Pangrol, Panzinorm, Pankreazim, Pankreal Kirshner, Pancreatin-ICN, Pancretin LekT, Pancreatin Forte, Pancreatin 8000, Pancreatin 25 IU (Belmed preparations), Pancreatin for children, Pancreatin-Health Forte 14000; Pancrenorm, Pancreon, Prolipase, Triferment, Uni-Festal, Festal (Festal N), Enzistal, Ermital, etc.

Attention: the use of analogues must be agreed with the attending physician.

Prices

The average price of PANCREATIN in pharmacies (Moscow) is 20 rubles.