The combination of calcium carbonate + calcium lactogluconate may reduce the absorption of estramustine, etidronate and possibly other bisphosphonates, phenytoin, quinolones, oral tetracycline antibiotics and fluoride preparations. The interval between taking effervescent calcium carbonate + calcium lactogluconate tablets and the above drugs should be at least 3 hours. Simultaneous administration of vitamin D and its derivatives increases calcium absorption. When appointed to high doses Together with vitamin D and its derivatives, calcium may reduce the effect of verapamil and possibly other calcium channel blockers. At simultaneous use effervescent tablets calcium carbonate + calcium lactogluconate and tetracycline drugs may interfere with the absorption of the latter. For this reason, tetracycline preparations should be taken at least 2 hours before or 4-6 hours after ingesting calcium preparations. Thiazide diuretics reduce urinary calcium excretion, therefore, when used simultaneously with calcium carbonate + calcium lactogluconate effervescent tablets, regular monitoring serum calcium concentrations, since there is a risk of developing hypercalcemia. Systemic corticosteroids reduce calcium absorption. When used simultaneously, it may be necessary to increase the dose of effervescent calcium carbonate + calcium lactogluconate tablets. When ingesting effervescent calcium carbonate + calcium lactogluconate tablets in patients receiving cardiac glycosides, the toxicity of cardiac glycosides may increase due to the development of hypercalcemia. Such patients should regularly take an ECG and monitor the level of calcium in the blood serum. At simultaneous administration oral bisphosphonate or sodium fluoride, these drugs should be taken at least 3 hours before taking effervescent calcium carbonate + calcium lactogluconate tablets, since absorption from gastrointestinal tract(Gastrointestinal) bisphosphonate or sodium fluoride may decrease. Calcium absorption from the gastrointestinal tract may be reduced by concomitant intake of certain foods containing oxalic acid (eg, spinach, rhubarb) or phytic acid (in all grains) due to the formation of insoluble complexes with calcium ions. Patients should not take calcium carbonate + calcium lactogluconate effervescent tablets 2 hours before or after eating a meal rich in oxalic or phytic acid.

Calcium Sandoz – pharmaceutical drug, which replenishes calcium deficiency in the body.

pharmachologic effect

The drug Calcium Sandoz is intended for oral administration. Calcium is vital mineral element, which maintains the balance of electrolytes in the body and also helps numerous regulatory mechanisms function properly.

Calcium Sandoz participates in phosphorus-calcium metabolism and has antiallergic and antirachitic effects. This drug is available in the form of effervescent tablets that contain a high dose of rapidly soluble ionized Ca salts.

Calcium Sandoz forte is dosage form, providing calcium in the form of a pleasant-tasting drink.

Pharmacokinetics

Approximately 30 percent of calcium is absorbed from the gastrointestinal tract. According to biological data, bones and teeth contain 99 percent of all Ca in the body.

50 percent of Ca is present as ionized calcium, 5 percent is located in anionic complexes, and 45 percent of calcium is bound to proteins. Approximately 20 percent of Ca is excreted through urine, and 80 percent is excreted through feces.

Calcium is excreted in feces as an unabsorbed element. This element is also excreted as an adsorbed substance, which is excreted in bile and pancreatic secretions.

Directions for use and dosage

According to the instructions, Calcium Sandoz should be taken 1-2 tablets per day. If the patient has a severe case, the dose should be increased to 4 tablets per day (4 tablets equal two grams of ionized calcium).

Before taking the tablet, it should be dissolved in water.

Indications for use

The drug is prescribed in the following cases:

• For the prevention of postmenopausal bone demineralization;
• Osteoporosis;
• To soften bone tissue(the drug is used as an additional therapy);
• Rickets;
• The drug is prescribed in those conditions that are characterized by an increased need for calcium. This could be pregnancy, lactation, intensive growth in children;
• The drug is used for allergic reactions(used as an aid).

Use for renal impairment

People with mild or moderate renal impairment need regular monitoring of urinary calcium excretion. If necessary, the dose should be reduced or discontinued.

Contraindications

Calcium Sandoz Forte is not used in cases where the patient has an increase in calcium levels, severe renal failure, or hypercalciuria. The drug is not prescribed for hypersensitivity to medicine or its individual components.

Interaction with alcohol

No data on interactions with alcohol have been reported. When taking calcium, it is recommended to refrain from drinking alcoholic beverages containing high percent alcohol.

Overdose

No cases of acute overdose have been reported. According to the instructions, Calcium Sandoz can cause gastrointestinal disorders, but will not lead to hypercalcemia (an exception may be the fact that the patient was simultaneously prescribed vitamin D in high doses or its derivatives).

Drug interactions Calcium Sandoz

Sandoz Forte Calcium effervescent tablets are designed to reduce the absorption of etidronate, estramustine, quinolones, and other bisphosphonates, as well as fluoride preparations.

If a patient is prescribed a drug with simultaneous use of vitamin D, it increases calcium absorption.

Calcium absorption from the gastrointestinal tract is reduced when certain foods are consumed. This includes rhubarb, cereal bran, and spinach. If the drug is prescribed with vitamin D, calcium reduces the response to verapamil.

Pregnancy and lactation

During pregnancy daily dose calcium should not be more than 1500 milligrams. If the mother develops hypercalcemia, it can have severe effects on mental and physical development fetus

Conditions and shelf life

Calcium Sandoz should be stored at a temperature not exceeding 25 degrees Celsius.

Shelf life - 3 years.

The medicine is dispensed from pharmacies without a prescription.

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Prevention and treatment of calcium deficiency; prevention and treatment of osteoporosis (in complex therapy); treatment of rickets and osteomalacia (in complex therapy with vitamin D3).

Pharmacotherapeutic group

Calcium-phosphorus metabolism regulator.

Pharmacological property

Calcium is a vital mineral element necessary to maintain the balance of electrolytes in the body and the adequate functioning of numerous regulatory mechanisms. Replenishes Ca2+ deficiency in the body, participates in phosphate-calcium metabolism, has vitamin, antirachitic, anti-inflammatory and antiallergic effects. Calcium Sandoz Forte contains two calcium salts (calcium lactogluconate and calcium carbonate), which in the form of effervescent tablets quickly dissolve in water, turning into an active ionized form of calcium, which is easily absorbed. This dosage form ensures an adequate supply of calcium to the body in the form of a tasty drink and is intended for the prevention and treatment of acute and chronic calcium deficiency in the body, as well as for the treatment of various types of metabolic disorders in bone tissue.

Contraindications

Increased sensitivity to the components of the drug, increased concentration of calcium in the blood and urine (hypercalcemia, hypercalciuria), chronic renal failure, nephrourolithiasis, nephrocalcinosis, phenylketonuria and sucrose/isomaltose deficiency, fructose intolerance, glucose-galactose malabsorption. Calcium Sandoz Forte is not recommended for use in children under 3 years of age due to the lack of data on effectiveness and safety in this category.

Application

Inside, regardless of food intake. Before taking, the tablet is dissolved in a glass of water. Children from 3 to 9 years old: 500 mg per day. Adults and children over 10 years old: 1000 mg per day. In severe cases or with an increased need for calcium (for example, when treating with bisphosphonates), the dose may be increased to 2000 mg per day. Duration of therapy : when used for the prevention and treatment of calcium deficiency average duration the course of treatment is at least 4 - 6 weeks; when used for the prevention and treatment of osteoporosis, treatment of rickets and osteomalacia, the duration of treatment is determined individually.

Side effects

Immune system disorders: rarely: hypersensitivity reactions, incl. rash, itching, urticaria; very rare: systemic allergic reactions (such as anaphylactic reactions, facial edema, angioedema) have been reported in isolated cases. Metabolic and nutritional disorders: uncommon: hypercalcemia, hypercalciuria. Gastrointestinal disorders: rarely: flatulence, constipation, diarrhea, nausea, vomiting, abdominal pain. When taken in high doses (2000 mg/day when taken daily for several months), there may be headache, increased fatigue, thirst, polyuria.

Overdose

Overdose leads to the development of hypercalciuria and hypercalcemia. Symptoms of hypercalcemia: nausea, vomiting, thirst, polydipsia, polyuria, dehydration and constipation. Chronic overdose with the development of hypercalcemia can lead to liming of blood vessels and organs. The threshold for calcium intoxication is when taking calcium supplements for several months at a dose exceeding 2000 mg/day. Therapy in case of overdose In case of intoxication, therapy should be stopped immediately and the water and electrolyte balance should be restored. In case of chronic overdose, if signs of hypercalcemia are detected at the initial stage, hydration is carried out using a 0.9% sodium chloride solution. To enhance the excretion of calcium, as well as to avoid the formation of edema in the tissues (for example, in congestive heart failure), loop diuretics, for example, furosemide, can be used. In this case, you should refrain from using thiazide diuretics. In patients with renal failure hydration is ineffective; dialysis is indicated for such patients. In the case of persistent hypercalcemia, other factors contributing to its development should be excluded, including hypervitaminosis of vitamin A or D, primary hyperparathyroidism, malignant tumors, renal failure, and stiffness.

Interaction with other drugs

The combination of calcium carbonate + calcium lactogluconate may reduce the absorption of estramustine, etidronate and possibly other bisphosphonates, phenytoin, quinolones, oral tetracycline antibiotics and fluoride preparations. The interval between taking effervescent calcium carbonate + calcium lactogluconate tablets and the above drugs should be at least 3 hours. Simultaneous administration of vitamin D and its derivatives increases calcium absorption. When prescribed in high doses along with vitamin D and its derivatives, calcium may reduce the effect of verapamil and possibly other calcium channel blockers. With the simultaneous use of effervescent calcium carbonate + calcium lactogluconate tablets and tetracycline drugs, the absorption of the latter may be impaired. For this reason, tetracycline preparations should be taken at least 2 hours before or 4-6 hours after ingesting calcium preparations. Thiazide diuretics reduce urinary calcium excretion, therefore, when used concomitantly with calcium carbonate + calcium lactogluconate effervescent tablets, regular monitoring of serum calcium concentrations should be carried out, as there is a risk of developing hypercalcemia. Systemic corticosteroids reduce calcium absorption. If they are used simultaneously, it may be necessary to increase the dose of effervescent calcium carbonate + calcium lactogluconate tablets. When ingesting effervescent calcium carbonate + calcium lactogluconate tablets in patients receiving cardiac glycosides, the toxicity of cardiac glycosides may increase due to the development of hypercalcemia. Such patients should regularly take an ECG and monitor the level of calcium in the blood serum. If a bisphosphonate or sodium fluoride is taken orally, these drugs should be taken at least 3 hours before taking calcium carbonate + calcium lactogluconate effervescent tablets, since absorption from the gastrointestinal tract (GIT) of the bisphosphonate or sodium fluoride may be reduced. Calcium absorption from the gastrointestinal tract may be reduced by concomitant intake of certain foods containing oxalic acid (eg, spinach, rhubarb) or phytic acid (in all grains) due to the formation of insoluble complexes with calcium ions. Patients should not take calcium carbonate + calcium lactogluconate effervescent tablets 2 hours before or after meals rich in oxalic or phytic acid.

1 calcium tablet lactogluconate 1132 mg or 2263 mg, calcium carbonate 875 mg or 1750 mg.

Citric acid, butyl hydroxyanisole, macrogol 6000, , sodium bicarbonate, flavoring, as excipients.

Release form

Soluble tablets 500 mg and 1000 mg.

pharmachologic effect

Replenishment of calcium deficiency.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Calcium is important element, which is necessary for the regulation of many processes in the body, maintaining electrolyte balance and participation in phosphate-calcium metabolism. This drug replenishes its deficiency when various states, and is prescribed for metabolic disorders in bone tissue. Renders antirachitic And antiallergic action.

The drug contains two calcium salts, which in the form of effervescent tablets quickly dissolve, turning into the active form. This dosage form ensures easy absorption and entry of calcium into the body.

Pharmacokinetics

About 25–50% of ionized calcium is absorbed into small intestine and enters calcium depots. Largest quantity it (99%) is found in bones and teeth, 1% is found in extracellular fluid. About 50% of total calcium in the blood is present in active ionized form, 5% in the form of anionic complexes, and 45% is bound to proteins. Approximately 20% is excreted by the kidneys in urine and 80% in feces. The degree of excretion by the kidneys depends on glomerular filtration.

Indications for use

• in postmenopause;
• drug-induced osteoporosis;
• insufficiency in the diet;
• osteomalacia (in combination with vitamin D3);
• allergic reactions;
• increased need (during pregnancy, breastfeeding, period of intensive growth);
• latent course tetany .

Contraindications

• chronic;
• hypercalcemia , hypercalciuria ;
• hypersensitivity to the drug;
• , nephrocalcinosis ;
• , fructose intolerance;
• age up to 3 years.

Side effects

Very rarely, Calcium Sandoz Forte can cause:

• rash, facial swelling, itching, urticaria, ;
• hypercalcemia , hypercalciuria ;
• , vomiting, nausea, epigastric pain.

When taking 2000 mg per day for several months, headache, thirst, fatigue, polyuria .

Instructions for use (Method and dosage)

The tablet is dissolved in water and taken orally regardless of meal time. Adults are prescribed 1000 mg/day. If the need is increased, the dose is increased to 2000 mg/day. Children from 3 years of age: 500 mg/day, and from 10 years of age, an adult dose is prescribed.

The duration of treatment is 4–6 weeks. For prevention and treatment osteoporosis The duration of treatment is determined individually.

At pregnancy daily dose is not more than 1500 mg. In patients with impaired renal function and in the presence urolithiasis Constant monitoring of calcium in urine is necessary.

Overdose

Overdose of Calcium Sandoz Forte manifests itself with symptoms hypercalcemia : nausea, vomiting, polyuria , thirst, polydipsia , dehydration , constipation. When taking more than 2000 mg/day for several months, it appears chronic overdose, which can lead to liming of blood vessels .

Treatment: restoration of water and electrolyte balance - carried out hydration .In order to enhance the excretion of the drug, they are used loop diuretics (), thiazide diuretics are not assigned. Patients with renal failure shown dialysis .

Interaction

Due to the formation of non-absorbable complexes, the drug may reduce the absorption of the cytostatic estramustine ,bisphosphonate etidronate , drugs fluoride , tetracyclines , quinolones . Therefore, the interval between taking these drugs and effervescent tablets should be 3 hours or more.

Co-administration with vitamin D increases the absorption of calcium, which reduces the effect.

Thiazide diuretics reduce the excretion of the drug in the urine, and there is a risk of developing hypercalcemia, and therefore, when prescribing these diuretics simultaneously, it is necessary to monitor the calcium level in the blood.

Corticosteroids reduce its absorption, so it may be necessary to increase the dose.

Due to the development of hypercalcemia when taken simultaneously cardiac glycosides their toxicity increases. ECG should be monitored regularly.

Absorption of the drug from the gastrointestinal tract is reduced when consuming spinach, rhubarb (oxalic acid) or grains containing phytic acid, since insoluble complexes are formed. In this case effervescent tablets must be taken 2 hours before eating this meal.

Terms of sale

Over the counter.

Storage conditions

At a temperature not exceeding 30°C.

Best before date

Analogues

Level 4 ATX code matches:

, , CalViv .

Reviews of Calcium Sandoz Forte

Let us remind you that daily norm calcium increases with age and amounts to 1000-1500 mg/day, and the source of its intake does not matter - food or medications. If the diet contains 1000 mg, then only 200-300 mg is included in metabolism. Dairy products contain the most of this element, and it is absorbed almost completely. In green vegetables and cereals it is found in the form of insoluble salts (oxalates and phosphates), the absorption of which is significantly lower.

The drug is prescribed in cases where there is an increased need for calcium (pregnancy, increased growth of the child), with diabetic osteoarthropathy , rickets , allergic dermatitis .

To improve the healing of fractures and prevent osteoporosis, Calcium Sandoz Forte is also prescribed. Reviews from doctors indicate the effectiveness of this drug in various pathologies bone tissue. Employees of the Department of Traumatology and Orthopedics of the Belarusian State Medical University in Ufa published the results of the use of this drug in complex treatment(With vitamin D And bisphosphonates ) juvenile osteoporosis in children. It is noted that the drug contains rapidly soluble ionized salts ( lactogluconate And carbonate ), which have high bioavailability, that is, they are well absorbed, which cannot be said about calcium gluconate . However, it reduces acidity gastric juice. Calcium Sandoz Forte is approved for use in children from 3 years of age, which expands the possibilities of its use. For example, And Calcemin Advance can only be used in children over 12 years of age. It is better to take the drug in the evening, since at this time maximum absorption is observed (after 19 hours).

At the Department of Gynecology of Minsk medical institute, developing methods for correcting osteoporosis, have once again proven that the role of calcium metabolism disorders in the occurrence of osteoporosis is undeniable, but its preparations and vitamin D are not the basis for treatment. The basis for the prevention and treatment of osteoporosis is hormone replacement therapy (estrogens And gestagens in various combinations). And calcium supplements, bisphosphonates, vitamin D, calcitonin and fluorides are used in the complex treatment of this disease. It should be taken into account that drugs containing well-absorbed salts will be effective for this disease.

Analyzing reviews of Calcium Sandoz Forte, we can draw a conclusion about the effectiveness of the drug. Users note its availability in the pharmacy chain, convenient form release - instant tablets soluble in water.

“I couldn’t swallow tablets from other manufacturers because of their large size. And these are a pleasure"

“I think that I saved my teeth during pregnancy and breastfeeding only thanks to these tablets. Reviews are only positive"

“My hair began to fall out a lot and my nails began to break. I took 20 tablets and felt improvements in my hair and nails.”

According to reviews, the drug is well tolerated; only some people noted pain in the stomach and constipation with long-term use.

Price Calcium Sandoz Forte, where to buy

You can buy it in many pharmacies in Moscow and other cities. The price of Calcium Sandoz Forte 500 mg No. 10 ranges from 163 rubles. up to 244 rub. The cost of tablets 1000 mg No. 10 is from 320 rubles. up to 404 rub.