Sum of belladonna alkaloids trade name. Belladonna preparations. Belladonna preparations and atropine

Title: Belladonna sum of alkaloids International name: Belladonna leaves (Belladonnae folia) Description active substance(INN): Belladonna leaves Dosage form: tincture, rectal suppositories, plant raw materials-powder pharmachologic effect: Means plant origin. It has an anticholinergic and antispasmodic effect. Interferes with the stimulating effect of acetylcholine; reduces the secretion of the salivary, gastric, bronchial, lacrimal, sweat glands, and the exocrine function of the pancreas. Reduces muscle tone of the gastrointestinal tract, bile ducts and gallbladder, but increase sphincter tone; causes tachycardia, improves AV conduction. Dilates pupils, complicates outflow intraocular fluid, increases intraocular pressure, causes paralysis of accommodation. Indications: Peptic ulcer of the stomach and duodenum, cholelithiasis, spasm of smooth muscles of organs abdominal cavity, biliary colic, renal colic; bradycardia, AV block; hemorrhoids, fissures anus. Contraindications: Hypersensitivity, angle-closure glaucoma, prostatic hypertrophy with impaired urine outflow. Side effects: Dry mouth, mydriasis, accommodation paresis, intestinal atony, dizziness, tachycardia, urinary retention, hyperemia of the skin of the eyelids, photophobia. Overdose. Symptoms: psychomotor agitation, paralysis of accommodation, acute urinary retention. Directions for use and dosage: Orally, adults - 5-10 drops of tincture 3-4 times a day; children - 1-5 drops. The highest dose for adults: single - 0.5 ml (23 drops), daily - 1.5 ml (70 drops). The thick extract is taken at 0.01-0.02 g; highest single dose- 0.05 g, daily - 0.15 g. Dry extract - 0.02-0.04 g each; the highest single dose is 0.1 g, the daily dose is 0.3 g. Rectally, 1 suppository 2-3 times a day; maximum dose- 10 candles per day. special instructions: During the treatment period, care must be taken when driving vehicles and engaging in other potentially dangerous species activities that require increased concentration, speed of psychomotor reactions and good vision.
Before using the drug Belladonna total alkaloids, you should consult your doctor. This instruction is intended for informational purposes only and is not intended to prescribe treatment without the participation of a physician.

Other drugs in the group Antispasmodic

Belladonna Preparations Belladonna Preparations. Belladonna leaves (Folia Atropae belladonnae). Leaves of a perennial cultivated plant collected at the beginning of budding before mass fruiting herbaceous plant belladonna (belladonna) - Аtropa belladonna L., fam. Solanaceae - Solanaseae. The plant contains alkaloids of the atropine group (hyoscyamine, scopolamine, apoatropine, etc.). The content of alkaloids in the leaves (in terms of hyoscyamine) must be as required State Pharmacopoeia not less than 0.3%; with an alkaloid content of more than 0.3% for preparation dosage forms leaves are taken in correspondingly smaller quantities. Pharmacological properties belladonnas coincide mainly with the properties of atropine. Belladonna preparations (extracts, tinctures) are used as antispasmodics and analgesics for gastric ulcers, cholelithiasis and other diseases accompanied by spasms of the smooth muscles of the abdominal organs, with bradycardia due to overexcitation vagus nerve etc. Contraindicated for glaucoma. Belladonna leaf and preparations obtained from it (extracts, tinctures) are stored with caution (list B). Tincture of belladonna (Tinctura Belladonnae). Clear liquid greenish or reddish-brown in color with a peculiar odor and bitter taste. Prepared from belladonna leaves (1:10) in 40% alcohol; contains 0.027-0.033% alkalodes. Prescribed orally: adults 5-10 drops per dose; children 1 - 5 drops per dose depending on age. Higher doses for adults: single 0.5 ml (23 drops), daily 1.5 ml (70 drops). Release form: in bottles of 10 ml. Belladonna tincture is part of the so-called Zelenin Drops (see) and other combined dosage forms. Belladonna (belladonna) thick extract (Extractum Belladonnaе spissum). A thick mass of dark brown color with a peculiar odor. Contains from 1.4 to 1.6% alkaloids. Included in a number of combined dosage forms. Single doses: 0.01 - O.O15 - 0.02 g. Higher doses for adults orally: single O.05 g, daily 0.15 g. Dry belladonna extract (Extractum Belladonnae siccum). Powder of brown or light brown color with a faint odor and peculiar taste. Hygroscopic. Contains 0.7 - 0.8% alkaloids. Due to the lower content of alkaloids in the manufacture of dosage forms, the dry extract is used in double quantity relative to the thick extract. Higher oral doses for adults: single 0.1 g, daily 0.3 g. The following medications are available containing powder from the leaves and extracts from the leaves and roots of belladonna. Anti-asthmatic collection (Sсies antiasthmaticae) (list B). Synonyms: anti-asthma powder, Pulvis antiasthmaticus. Ingredients: belladonna leaves 2 parts, henbane leaves 1 part, datura leaves 6 parts, sodium nitrate 1 part. Brownish-green powder with a peculiar odor. Contains 0.2 - 0.25% alkaloids. Once lit, it smolders slowly and evenly until completely ashed. Used for bronchial asthma. Burn half a teaspoon and inhale the smoke or smoke a cigarette containing the specified powder. Tablets "Becarbon" (Tabulletae "Becarbonum"). Ingredients: belladonna extract 0.01 g, sodium bicarbonate 0.3 g. Take 1 tablet 2 - 3 times a day for intestinal spasms, increased acidity gastric juice. Tablets "Besalol" (Tabulettae "Besalolum"). Ingredients: belladonna extract 0.01 g, phenyl salicylate 0.3 g. For use, see Bepasal. Tablets "Bepasal" (Tabulettae "Bepasalum"). Composition: phenyl salicylate (salol) 0.3 g, papaverine hydrochloride 0.03 g, belladonna extract 0.012 g. Spasmodic, anticholinergic and antiseptic. Prescribed for diseases gastrointestinal tract one tablet 2 - 3 times a day. Tablets "Bellalgin" (Tabulettae "Bellalginum"). Ingredients: analgin and anesthesin 0.25 g each, belladonna extract 0.015 g, sodium bicarbonate 0.1 g. Antispasmodic, antacid and analgesic agent. Prescribed mainly for diseases of the gastrointestinal tract, accompanied by high acidity, smooth muscle spasms, and pain. Take 1 tablet orally 2-3 times a day (after meals). The highest dose for adults: single dose 3 tablets, daily dose 10 tablets. Storage: List B. In a place protected from light. Bellastesin tablets, see Anestezin. Stomach tablets with belladonna extract (Tabulettae Stomachicae cum extracto Belladonnae). Ingredients: belladonna extract 0.01 g, wormwood extract 0.012 g, valerian extract 0.05 g. Take 1 tablet 2 - 3 times a day. Storage: list B. Candles "Bethiol" (Suppositoria "Bethiolum"). Ingredients: belladonna extract 0.015 g, ichthyol 0.2 g, suppository base 1.185 g. Used for hemorrhoids and anal fissures. Release form: in a package of 10 pieces. Suppositoria "Anusolum" (Suppositoria "Anusolum"). Ingredients: belladonna extract 0.02 g, xeroform 0.1 g, zinc sulfate 0.05 g, glycerin 0.12 g, suppository base 2 g. Used for hemorrhoids and anal fissures. Release form: in boxes of 10 pieces, as well as candles containing 0.015 g of belladonna extract. The amount of alkaloids from belladonna roots is included in the tablets "Bellataminal", "Belloid" (Hungary), and the drug "Solutan". Tablets "Bellataminal" (Tabulettae "Bellataminalum"). Film-coated tablets containing phenobarbital 0.02 g (20 mg), ergotamine tartrate 0.0003 g (0.3 mg), total belladonna alkaloids 0.0001 g (0.1 mg). In composition and action, bellataminal is similar to the drug "Bellaspon".* The pharmacological properties of bellataminal and its analogues correspond to the action of their components: the drugs reduce the excitability of the central and peripheral adrenergic and cholinergic systems of the body, and have a calming effect on the central nervous system. Used for increased irritability, insomnia, menopausal neuroses, neurodermatitis, vegetative dystonia. Prescribe 1 tablet 2-3 times a day (after meals). Due to the content of ergotamine (see), which can cause contraction of the uterus and blood vessels, the tablets are contraindicated during pregnancy and during childbirth, with spasms of the heart and peripheral vessels, in advanced stages of atherosclerosis. Also contraindicated for glaucoma. Storage: List B. In a place protected from light. Dragee "Belloid"* (Belloid). Composition: 0.3 mg ergotoxin, 0.1 mg total belladonna alkaloids and 0.03 g butylethylbarbituric acid. Taken for increased irritability, insomnia, vegetative dystonia, Meniere's syndrome, neurogenic disorders associated with menstrual cycle, hyperthyroidism, etc. 1 - 2 tablets (dragées) 3 times a day. Contraindications: see Bellataminal tablets. Release form: in a package of 50 tablets. Solutan*. Contains in 1 ml radobelin (alkaloid of belladonna root) 0.1 mg, saponin (Saponinum gipsophillae) 1 mg, dill oil 0.4 mg, novocaine 4 mg, ephedrine hydrochloride 17.5 mg, sodium iodide 0.1 g, tolutan extract balsam 25 mg, bitter almond water 30 mg, alcohol and water up to 1 ml. Transparent liquid of yellow-brown or orange-brown color. Over time, a fine precipitate, soluble when agitated, may form. The occurrence of sediment does not reduce the effectiveness of the drug. It has a bronchodilator (cholinergic and antispasmodic) and expectorant effect. Used for bronchial asthma and bronchitis. Prescribed orally for adults, 10-30 drops 3 times a day (after meals). For asthmatic attacks, up to 60 drops are prescribed per dose; they are also used for inhalation. Children are prescribed 5-10 drops 3 times a day (with milk or tea). At large doses possible side effects, characteristic of belladonna group drugs (dry mouth, dilated pupils, etc. Contraindicated in glaucoma. Release form: in 50 ml bottles (list B). Rp.: T-rae Belladonnae 10 ml D.S. 5 - 10 drops 2 - 3 times a day Rp.: T-rae Belladonnae 10 ml T-rae Valerianae 20 ml Mentholi 0.25 D.S. 10 -15 drops 2 - 3 times a day Rp.: T-rae Belladonnae 5 ml T-rae Convallariae T-rae Valerianae aa lO ml Mentholi 0.2 D.S. 10 - 15 drops 2 - 3 times a day Rp.: Extr. Belladonnae 0.015 Natrii hydrocarbonatis 0.25 D.t.d. N. 6 in tab. S. 1 tablet 2 - 3 times a day Rp. : Magnesii oxydi 0.5 Bismuthi subnitratis 0.2 Extr. Belladonnae 0.01 M.f. pulv. D.t.d. N. 10. S. 1 powder 2 - 3 times a day (with increased acidity of gastric juice)

Dictionary of medicines. 2005 .

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Belladonna leaves (Belladonna preparations) are an anticholinergic agent. Atropa belladonna Contents 1 Belladonna leaves 2 On ... Wikipedia

raw materials plant extract dry: jars Reg. No.: P N000548/01

Clinical and pharmacological group:

A drug with antispasmodic and analgesic effects for local use in proctology

Release form, composition and packaging

Vegetable raw materials -dry extract.

dark glass jars (1) - wrapping paper.

Description of the active components of the drug " Belladonna»

pharmachologic effect

Herbal product. Contains alkaloids atropine, hyoscyamine, scopolamine, which have m-cholinolytic activity. Blocks m-cholinergic receptors and prevents the interaction of acetylcholine with them - a mediator of the parasympathetic department of the autonomic nervous system. Reduces the secretion of digestive, bronchial, lacrimal, and sweat glands. Relaxes smooth muscles and causes spasm of intestinal sphincters, bile and urinary tract, has a bronchodilator effect, mainly on small bronchi and bronchioles. Causes pupil dilation and paralysis of accommodation, increasing intraocular pressure. Reduces the cholinergic effect of the vagus nerve on the heart. As a result of the predominance of the adrenergic (sympathetic) effect on the heart, tachycardia occurs and AV conduction improves. It has virtually no effect on blood vessels and blood pressure levels.

The duration of the resorptive action of alkaloids ranges from 2 to 6 hours. local application on the mucous membrane of the eyes, accommodation is disrupted for 3-4 days, mydriasis persists for up to 7-10 days.

In high doses it has a stimulating effect on the cortex cerebral hemispheres brain, causes motor and speech excitation, hallucinations, activates, and with increasing dose depresses the respiratory center.

Indications

For systemic use: spasms smooth muscle organs Gastrointestinal tract, biliary and urinary tracts, hypersecretory gastritis, peptic ulcer stomach and duodenum, pancreatitis, hypersalivation, poisoning with salts of heavy metals, m-cholinomimetics, anticholinesterase drugs, obstructive bronchitis, bronchial asthma, premedication before surgical interventions, bradyarrhythmias, AV block, prevention of cardiac arrest and bronchospasm during anesthesia.

For local use in ophthalmology: for examination of the fundus of the eye, for the treatment of iritis, iridocyclitis, choroiditis, keratitis, embolism and spasm of the central retinal artery, some eye injuries.

Dosage regimen

Individual. The dose, frequency and duration of use depend on the indications, the age of the patient and the dosage form used.

Side effect

For systemic use: possible headache, nervousness, drowsiness, weakness, dizziness, sleep disorders, ataxia, speech impairment, agitation (especially in elderly patients), dry mouth, loss of taste, loss of appetite, constipation.

In case of overdose: nausea, vomiting, tachycardia, tachyarrhythmia, myocardial ischemia, impotence, suppression of lactation, idiosyncrasy, urticaria, decreased sweating, hyperthermia.

For local use: visual impairment, mydriasis, paralysis of accommodation, increased intraocular pressure, photophobia.

Contraindications

Glaucoma, suspected glaucoma, stenotic gastrointestinal diseases, intestinal atony, acute ulcerative colitis, mechanical intestinal obstruction, atonic constipation, benign prostatic hyperplasia, pronounced atherosclerosis, acute edema lungs, cardiac decompensation, tachyarrhythmia, acute bleeding, myasthenia gravis, lactation, increased sensitivity to belladonna.

Pregnancy and lactation

The use of belladonna during pregnancy is only possible if the expected benefit to the mother outweighs the potential risk to the fetus.

During lactation ( breastfeeding) the use of belladonna is contraindicated.

Use for renal impairment

Use with caution in patients with kidney disease.

special instructions

Use with caution in patients with polyneuropathy, hyperthyroidism, ischemic heart disease, chronic heart failure, hypertension, kidney diseases, diaphragmatic hernia, reflux esophagitis. Long-term use is not recommended for gallstone disease and nephrolithiasis.

At high temperature environment Using belladonna can cause heat stroke.

Impact on the ability to drive vehicles and operate machinery

Drug interactions

Drug interactions

Belladonna reduces or eliminates the effect of m-cholinomimetics and anticholinesterase drugs.

Potentiates the arrhythmogenic effect of MAO inhibitors, cardiac glycosides, clonidine, the anticholinergic properties of quinidine, novocainamide, the effects of barbiturates, adrenomimetics, antihistamines, tranquilizers.

With lead acetate, calcium salts, tannin, tincture of lily of the valley it forms a sediment.

Trade name:

Belladonna sum of alkaloids

Belladonna leaves (Belladonnae folia)

Antispasmodic

Description of the active substance (INN):

Belladonna leaves

tincture, rectal suppositories, vegetable raw materials-powder

Herbal product. It has an anticholinergic and antispasmodic effect. Interferes with the stimulating effect of acetylcholine; reduces the secretion of the salivary, gastric, bronchial, lacrimal, sweat glands, and the exocrine function of the pancreas. Reduces the tone of the muscles of the gastrointestinal tract, bile ducts and gallbladder, but increases the tone of the sphincters; causes tachycardia, improves AV conduction. Dilates the pupils, impedes the outflow of intraocular fluid, increases intraocular pressure, and causes paralysis of accommodation.

Peptic ulcer of the stomach and duodenum, cholelithiasis, spasm of smooth muscles of the abdominal organs, biliary colic, renal colic; bradycardia, AV block; hemorrhoids, anal fissures.

Hypersensitivity, angle-closure glaucoma, prostatic hypertrophy with impaired urine outflow.

Dry mouth, mydriasis, accommodation paresis, intestinal atony, dizziness, tachycardia, urinary retention, eyelid skin hyperemia, photophobia. Overdose. Symptoms: psychomotor agitation, paralysis of accommodation, acute urinary retention.

Orally, adults - 5-10 drops of tincture 3-4 times a day; children - 1-5 drops. The highest dose for adults: single - 0.5 ml (23 drops), daily - 1.5 ml (70 drops). The thick extract is taken at 0.01-0.02 g; the highest single dose is 0.05 g, the daily dose is 0.15 g. Dry extract is 0.02-0.04 g; the highest single dose is 0.1 g, the daily dose is 0.3 g. Rectally, 1 suppository 2-3 times a day; the maximum dose is 10 suppositories per day.

During the treatment period, care must be taken when driving vehicles and engaging in other potentially dangerous activities that require increased concentration, speed of psychomotor reactions and good vision.

Description of the drug Belladonna sum of alkaloids is not intended for prescribing treatment without the participation of a doctor.
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