Phosphogliv or essliver which is better. Phosphogliv or Essentiale - which is better? Comparison of drugs. Common features of the two drugs

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Phosphogliv is a drug from the group hepatoprotectors made from natural plant materials. Phosphogliv was developed as an improved analogue of the well-known drug Essentiale.

The drug has antiviral, immunostimulating, anti-inflammatory and antioxidant effects. Hepatoprotective action consists of a combination of these effects. In addition, Phosphogliv restores the structure of the membrane shell of liver cells, making it complete and complete. Also, the drug improves the ability of the liver to neutralize various toxic substances. By providing comfortable conditions for the liver, Phosphogliv is able to reduce the risk of fibrosis or cirrhosis.

Phosphogliv is used in therapy various diseases liver - hepatosis (fatty degeneration, etc.), toxic lesions organ (for example, alcohol, drugs, etc.). The drug is also used in complex therapy viral hepatitis, cirrhosis of the liver, and skin diseases such as psoriasis.

Drug names

Phosphogliv is the commercial name for the drug. There is also a grouping name that sounds like this: phospholipids + glycyrrhizic acid. The chemical name of Phosphogliv is correctly spelled as follows: phosphatidylcholine + trisodium salt of glycyrrhizic acid.

Composition and forms of release

To date, the drug Phosphogliv is available in the form of capsules.

Phosphogliv capsules have a hard gelatin shell, the body of which is painted orange, and the cap is black. Inside the capsules is a granular powdery content, colored in White color with a yellowish tint, and with a specific smell. Phosphogliv goes on sale in packs of 30, 50, 100, 200 or 300 capsules.

Phosphogliv contains two active substances a, this is:
1. Phospholipids (Lipoid C 80) (of which phosphatidylcholine makes up 73-79% of the substance) - 65 mg.
2. Trisodium salt of glycyrrhizic acid - 35 mg.

In addition, the composition of the drug includes a number excipients , this is:

microcrystalline cellulose;
calcium carbonate;
calcium stearate;
talc;
colloidal silicon dioxide.

The capsule body consists of the following substances:

dye sunset yellow;
titanium dioxide;
gelatin.

Capsule cap consists of the following substances:

iron dye black oxide;
titanium dioxide;
gelatin.

Photo of drug packaging

Phosphogliv forte

There is also a kind of drug called Phosphogliv Forte. It is produced on the territory of the Russian Federation, in the city of Kursk.

Pharmacological properties of the drug

The therapeutic effects of Phosphogliv are due to the phospholipids and glycyrrhizic acid that make up its composition.

So, phosphatidylcholine (the main substance phospholipids) is necessary structural component membranes of any cell. Thus, by affecting the state of cell membranes, phosphatidylcholine exhibits cytoprotective properties. Phosphatidylcholine also normalizes lipid and protein metabolism, prevents the loss of enzymes and other substances by liver parenchyma cells, normalizes the detoxifying function of the organ, inhibits the formation connective tissue, reducing the likelihood of developing fibrosis and cirrhosis of the liver.

Glycyrrhizic acid has an anti-inflammatory effect, inhibits the reproduction of viruses in the liver and other organs by increasing the production of interferons, increasing phagocytosis, and also enhancing the activity of natural killer cells. Shows hepatoprotective properties due to antioxidant and membrane-stabilizing action. By enhancing the action of endogenous glucocorticoids, it has an anti-inflammatory and anti-allergic effect in liver damage not associated with infection.

With lesions skin prevents an increase in the area of the lesion and helps to cure the pathology due to the stabilization of cell membranes and stopping the inflammatory process.

Indications for use

Phosphogliv is used for the following diseases:

Fatty degeneration of the liver;
Alcoholic, toxic (including drug-induced) liver damage;
As part of the complex treatment of acute and chronic viral hepatitis, liver cirrhosis and psoriasis.

Phosphogliv capsules - instructions for use

Capsules are taken orally during a meal, without chewing, washed down with clean water.

For children over 12 years of age and adults, it is optimal to take two capsules 3 times a day. The duration of the course of taking Phosphogliv can be no more than six months, on average - 3 months.

Overdose Phosphogliv was not detected even once during the entire period of drug use.

Interaction with other medicines also not installed.

Special instructions: in the event of an increase in blood pressure, it is necessary to stop the drug and consult a doctor.

Application during pregnancy

Phosphogliv capsules and lyophilizate are contraindicated for use by pregnant women. However, women suffering from chronic hepatitis or hepatosis, if necessary, a course of Phosphogliv is prescribed. But in such situations, the benefits of using the drug should exceed all possible side effects.

Infectious disease doctors in developed countries of Europe and the USA prefer not to prescribe Phosphogliv during pregnancy, because this drug activates immune mechanisms. Normally, in a pregnant woman, immunity is somewhat reduced, which is necessary for bearing a fetus. After all, if the immunity remains normal, then the woman will not be able to bear the child, since the immune system will cause miscarriages, considering the fetus to be some kind of alien genetic material. That is, increased activity immune system causes an increased risk of miscarriage. That is why it is better not to use Phosphogliv during pregnancy.

Phosphogliv for children

According to the instructions for use, Phosphogliv is used in children from 12 years of age. At the same time, children over 12 years of age take the drug in adult dosages - 2 capsules 3-4 times a day.

Phosphogliv is contraindicated for use in children under 12 years of age.

Phosphogliv in hepatitis C

Phosphogliv in hepatitis C is prescribed to maintain the functional activity of the liver, as well as to reduce the rate of development of fibrosis. Usually in this case, the drug is recommended to be used before the start antiviral therapy. Hepatologists consider it necessary to take Phosphogliv 2 capsules three times a day for 1 year or until the start of antiviral therapy.

However, it should be remembered that Phosphogliv can only reduce the activity of AST and ALT, maintain the normal functioning of the liver and prevent the development of fibrosis. But it is not a drug that can cure a person of hepatitis C. This type of hepatitis is treated exclusively with antiviral drugs, and Phosphogliv can be included in complex therapy as a means that effectively normalizes liver function.

Interaction with alcohol

Alcohol negatively affects the liver, increasing inflammatory and dystrophic processes. And Phosphogliv, on the contrary, normalizes the functioning of the organ and restores the integrity of the cells. That is why, against the background of the use of Phosphogliv, alcohol is contraindicated. But if necessary, during treatment with Phosphogliv, you can drink a small amount of alcohol, since there is no chemical antagonism between these substances. A small amount is allowed alcoholic beverages in between courses of taking a hepatoprotector.

Side effects

In the vast majority of cases, Phosphogliv does not cause adverse reactions and is well tolerated by patients. Very rarely, the drug can cause the following side effects:

Allergic manifestations:

difficulty in nasal breathing;

Heart and vessels:

temporary increase in blood pressure;
peripheral edema.

Digestive system:

dyspeptic phenomena (belching, nausea, flatulence);
discomfort in the abdomen.

In case of occurrence of the above side effects, it is necessary to stop the drug and consult a doctor.

Contraindications

Phosphogliv has contraindications, among which there are absolute and relative. In the presence of absolute contraindications the drug cannot be used in principle. And against the background of existing relative contraindications Phosphogliv can be used, but with caution and under careful medical supervision over the human condition.

Absolute contraindications to the use of Phosphogliv:

Hypersensitivity to the components of the drug;
Pregnancy;
Age under 12 years old.

Relative contraindications:

portal hypertension;
arterial hypertension .

Analogues

Phosphogliv is an original drug that has no analogues. However, today the domestic pharmaceutical market has a number of medicines, which, like Phosphogliv, contain essential phospholipids as active ingredients. Among them:

Brenciale forte - capsules;
Livolin forte - capsules;
Lipostabil - capsules and solution;
Rezalut Pro - capsules;
Phosphatidylcholine - capsules;
Phosfonciale - capsules;
Essel forte - capsules;
Essentiale, Essentiale N, Essentiale forte, Essentiale forte N - capsules and solution for intramuscular injections;
Essliver forte - capsules.

In addition, there are a number of hepatoprotectors that have a similar range of therapeutic effects, but contain other chemical compounds as active ingredients:

Hepa-Merz - granules for the preparation of a solution for oral administration and a concentrate for the preparation of a solution for intravenous administration;
Hepatosan - capsules;
Gepafor - capsules;
Geptrong - solution for intramuscular injection;
Glutargin - concentrate and solution for intravenous administration;
Glutargin - tablets and powder for oral solution;
Dipana - tablets;
Potassium orotate - tablets and granules for the preparation of syrup;
Karsil - dragee;
Karsil Forte - capsules;
Criomelt MN - solution for subcutaneous administration;
Laennec - solution for injection;
Legalon 140, Legalon 70 - capsules;
Liv.52 - tablets and drops for oral administration;
Maksar - tablets;
Methionine - tablets;
Metrop GP - solution for subcutaneous administration;
Peponen - capsules;
Prohepar - tablets;
Remaxol - solution for intravenous administration;
Ropren - drops for oral administration;
Rosilymarin - tablets;
Silibinin - tablets and dry extract;
Silibor - tablets;
Silimar - tablets and dry extract;
Silymarina Sediko - granules for the preparation of a suspension for oral administration;
Thiotriazolin - tablets and solution for intravenous and intramuscular administration;
Tykveol - capsules, rectal suppositories and oil for oral administration;
Pumpkin seed oil;
Cholenol - capsules;
VG-5 - tablets.

Reviews

Most of the reviews about Phosphogliv (about 4/5) are positive, which is associated with the good efficacy of the drug and relative cheapness. People who took Phosphogliv noted that the drug has excellent hepatoprotective properties, eliminating unpleasant symptoms associated with impaired liver function. Also, patients noted the excellent effect of the drug during the maintenance therapy of hepatitis C. Thus, biochemical parameters, such as the concentration of bilirubin and the activity of liver enzymes - AST, ALT and alkaline phosphatase, normalized in people, which made it possible to maintain the liver in good condition. functional state while waiting for a course of antiviral therapy.

In addition, Phosphogliv perfectly helped people suffering skin diseases. Many people noted that after the course of Phosphogliv, the condition of the skin improved significantly, including acne and small pimples.

Only less than 20% of people who used Phosphogliv left negative reviews about the drug. Negative reviews are due to the fact that the drug did not help to get rid of liver problems for these specific people.

Reviews of doctors

Hepatologists and infectious disease specialists generally speak positively about Phosphogliv. Especially often it is prescribed in the complex therapy of hepatitis C, since the drug has a pronounced positive action on the liver and significantly inhibits the activity of virus reproduction. Japanese doctors prescribe Phosphogliv to all patients suffering from hepatitis C before starting antiviral therapy, since the drug in some cases even completely cures the disease and stops the virus from multiplying. That is why hepatologists speak positively about Phosphogliv in relation to hepatitis.

Also, doctors speak positively of Phosphogliv as a hepatoprotector, which is used for any liver damage of toxic, drug or alcoholic origin, and for hepatosis. Under these conditions, the drug normalizes biochemical analyzes, the state of the liver, and also significantly improves the overall well-being of a person. Doctors note that the complex therapy of various liver diseases with the use of Phosphogliv normalizes the state of the organ faster than without the use of this hepatoprotector.

Dermatologists who use the drug in the treatment of various skin diseases, including psoriasis, speak positively about Phosphogliv. Phosphogliv helped many girls and women get rid of pimples and acne, normalizing the condition of the liver and increasing its ability to neutralize toxic substances.

Negative feedback from doctors about Phosphogliv can only be seen in relation to specific treatment regimens. If in such schemes the doctor considers Phosphogliv to be superfluous, then he expresses a negative opinion. However, in general, the drug is not considered bad, it is only about the inappropriate use in this particular case.

Phosphogliv or Essentiale?

Both Essentiale and Phosphogliv are hepatoprotectors and contain phospholipids as active ingredients. At the same time, Essentiale contains exclusively phospholipids, and Phosphogliv also contains glycyrrhizic acid. This acid is a steroid saponin in its chemical structure, that is, it is similar in structure to the hormones of the human adrenal cortex (the properties of glycyrrhizic acid and its effect on the liver are described above). However, this difference in the composition of drugs is not always a criterion for choosing one of them. Each person's body is unique, and one patient better fit Phosphogliv, and to another - Essentiale. Therefore, before choosing a hepatoprotector and its dosage, you should consult your doctor.

It should also be noted that Essentiale contains products of lipid peroxidation, while Phosphogliv does not contain these compounds.

Heptral or Phosphogliv?

According to the latest orders of the Ministry of Health of the Russian Federation, Phosphogliv is one of the standard drugs for providing specialized medical care for severe and severe acute hepatitis C. medium degree gravity, as well as chronic hepatitis C. In turn, Heptral is not included in this list medicines. Thus, we can conclude that in chronic hepatitis C, as well as in severe and moderate acute hepatitis C, Phosphogliv should be preferred.

At the same time, Heptral is more effective drug for the treatment of ABP and toxic hepatitis. Therefore, for these diseases, Heptral should be preferred.

Otherwise, Heptral and Phosphogliv are comparable in effectiveness. therapeutic effect. Therefore, you can use any drug that, for some subjective reasons, is more like a person. However, do not forget that the body of each person is individual, so Heptral may be well suited for one patient, and Phosphogliv, on the contrary, for another.

Price in Russia and Ukraine

The different cost of Phosphogliv in the retail pharmacy chain is due to the trade margin, as well as the costs of transportation and storage of drugs. Approximate prices for Phosphogliv in pharmacy chains in Russia and Ukraine:
In Russia: Phosphogliv, 65 mg + 35 mg, 50 capsules - 404 - 478 rubles.
In Ukraine: Phosphogliv, 65 mg + 35 mg, 50 capsules - 103 - 137 hryvnias.

Official site

The official website of the drug is Phosphogliv.rf

Before use, you should consult with a specialist.

Alcohol abuse, toxic drug therapy and viral diseases adversely affect the health of the liver, which plays important role in hematopoiesis, metabolism and detoxification of the body. To restore liver cells (hepatocytes) and prevent liver failure patients are prescribed hepatoprotective drugs (for example, Heptral or Phosphogliv).

How are the drugs different?

The effectiveness and duration of treatment with Phosphogliv and Heptral differ significantly, because. These drugs have different composition and mechanism of protective action. According to them, they differ adverse reactions on therapy, indications and contraindications for the appointment and use.

Active substance

The active substance of Heptral is a derivative of the amino acid methionine (ademetionine). The mechanism of its action on liver cells is realized due to detoxification, antifibrosing, antioxidant and other medicinal properties.

stimulates the synthesis of phospholipids (components of the walls of hepatocytes) and the outflow of bile;
reduces the toxicity of bile acids;
increases the resistance of cell membranes to the action of free radicals, toxic drugs and products of their metabolism;
affects redox cellular reactions, accelerating the detoxification process;
participates in the biochemical reaction of aminopropylation, reducing the risk of hepatic tissue fibrosis.

The effectiveness of Phosphogliv is due to other mechanisms of action on hepatocytes. The composition of this drug includes phosphatidylcholine (an essential phospholipid) and glycyrrhizic acid compounds (glycyrates).

Since phospholipids are the main structural element of hepatocytes, it is assumed that their introduction into the body stimulates the regeneration of liver tissues, prevents the loss of essential substances (including enzymes) and slows down the process of fibrosis. However, due to the metabolism of phospholipids in the body, the action of Phosphogliv is largely due to the content of another component - glycyrate.

Compounds of glycyrrhizic acid have anti-inflammatory and hepatoprotective effects. The drug protects cells from destruction under the action of free radicals, stimulates the immune system, increases the activity of phagocytosis and the activity of killer lymphocytes. Potentiation of the action of endogenous corticosteroids leads to a decrease in inflammation and the severity of an allergic reaction (in non-infectious hepatitis).

Indications

The spectrum of application of Phosphogliv and Heptral in liver damage is different. Heptral is prescribed for the following pathologies:

fatty hepatosis (dystrophy of the liver tissue, complicated by stagnation of bile in hepatocytes);
chronic hepatitis of any etiology;
alcohol and drug intoxication provoked by ethanol, opioid drugs, antidepressants, combined contraceptives, anti-tuberculosis, antiviral, antibacterial and other drugs;
lesions of the biliary tract and gallbladder, not accompanied by the formation of stones;
cirrhosis of the liver;
hepatic encephalopathy of alcoholic and other etiology;
stagnation of bile in hepatocytes during pregnancy;
depression.

Heptral is also used to restore liver function after a course of cytotoxic drugs against cancer (chemotherapy) and premedication with antibiotics and hormonal agents.

Indications for taking Phosphogliv are the following diseases:

hepatosis;
hepatitis C and other types of viral inflammation of the liver;
hepatic cirrhosis;
toxic damage to hepatocytes (alcoholic, narcotic, drug, etc.);
psoriasis.

At skin lesions, cirrhosis and hepatitis Phosphogliv is prescribed only as part of a comprehensive treatment course.

Depending on the indications for taking hepatoprotectors, Phosphogliv and Heptral are prescribed in an infusion or oral dosage form.

Heptral is available in the form of enteric-coated tablets and powder for preparation. injection solution. The solution is administered intramuscularly or intravenously.

Phosphogliv is prescribed in the form of solid gelatin capsules or solution for intravenous infusion.

Contraindications

Contraindications to taking Heptral are the following pathologies:

genetic diseases affecting the metabolism of methionine and some B vitamins ( folic acid, cyanocobalamin, etc.);
hypersensitivity to ademetionine and auxiliary ingredients of the drug;
age less than 18 years.

In old age, the 1st trimester of pregnancy and during breastfeeding, the drug is allowed to be used only under strict indications. At bipolar disorders psyche and kidney failure, as well as during therapy with individual drugs (SSRIs, tricyclic antidepressants, Tryptophan), Heptral is prescribed with caution.

Phosphogliv should not be used under conditions such as:

antiphospholipid syndrome;
an allergic reaction to glycyrrhizic acid, phospholipids and additional components of the drug;
pregnancy;
breast-feeding.

Unlike Heptral, Phosphogliv can be administered to children over 12 years of age.

With portal and arterial hypertension in history, before using the drug, you should consult with your doctor.

Side effects of Heptral and Phosphogliv

The most common side effects of Heptral therapy are nausea, diarrhea and abdominal pain. More rare reactions to the drug are:

allergic manifestations (swelling of the larynx, itching, rash, erythema, bronchospasm, etc.);
infections ( infectious inflammation urinary tract);
disorders of the cardiovascular, nervous and musculoskeletal systems (dizziness, anxiety, dyssomnia, headache, impaired consciousness, hot flashes, phlebitis of superficial vessels, paresthesia, muscle spasms, joint pains);
pathological reactions of the gastrointestinal tract (flatulence, dyspepsia, disorders and bleeding of the gastrointestinal tract, vomiting, cirrhosis, hepatic colic);
general phenomena (malaise, chills, swelling, fever).

Pathological reactions during therapy with Phosphogliv are rare. Side effects of taking the drug include:

allergic manifestations (rash, allergic conjunctivitis, cough and difficulty breathing);
swelling;
promotion blood pressure which passes with the end of therapy;
dyspepsia, nausea, flatulence.

When pathological reaction on any of the hepatoprotectors, you should stop treatment and consult your doctor.

What is better to take - Heptral or Phosphogliv?

The preferred drug for liver restoration in a particular pathology is selected by a doctor. This takes into account the patient's history and the cost of the course of treatment.

The most effective hepatoprotector is Heptral, produced in infusion form. The low effectiveness of the tablet form of the drug is due to the low bioavailability of ademetionine when passing through the gastrointestinal tract: during treatment with tablets, no more than 5% of the active substance Heptral is absorbed.

The positive effect of phospholipids, which form the basis of Phosphogliv, is not confirmed by a number of studies.

A significant disadvantage is the possibility of side effects of hepatoprotectors. Due to the effect on the central nervous system, Heptral may impair concentration and adversely affect the ability to drive a car and mechanisms. Phosphogliv can become dangerous for hypertensive patients.

Phosphogliv is a domestic drug, so a course of treatment with phospholipids and glycyrates will cost the patient significantly less than the foreign drug Heptral. The difference in price is most noticeable in the treatment of tablets and capsules.

Super food for the liver. Helper Products

Doctors' opinion

Yurechko D.V., phlebologist, Krasnodar.

Heptral is one of the best hepatoprotectors. It restores liver tissue in toxic and viral hepatitis, and also helps to reduce the manifestations of post-alcohol depression. Against the backdrop of therapy intravenous infusions Heptral in patients improves rapidly general state biochemical parameters are normalized. The disadvantage is the high cost of the drug.

Izyumov S.V., psychiatrist, Samara.

Phosphogliv is a good drug that is often used to treat patients infected with various types viral hepatitis. The product contains an additive that stimulates the immune system and increases resistance to viruses. The hepatoprotector is actively used in narcological practice, most patients are satisfied with the results of therapy.

Allergy to the drug in practice did not occur. The only drawback of the drug is the high cost of its most active (injectable) form.

Many believe that alcohol abuse is at the heart of liver problems. However, this is not quite true. We absorb pollutants through our air and food every day. Unhealthy diet and medicines also negatively affect the liver. But it is not all that bad. How to effectively support liver regeneration? Which is better - "Phosphogliv" or "Essentiale"?

What drug to choose to restore the liver?

The liver is one of the most important organs when it comes to maintaining health. The amount of toxins that are filtered daily through the liver cells from the blood increases steadily throughout our lives. In addition to the body's internal toxins, alcohol, nicotine, drugs and medications of all kinds place a huge burden on the liver.

In addition, they do not add health and intestinal problems such as bloating, pesticides in food, and pollutants environment substances - heavy metals in drinking water and much more.

The sooner you help your liver build and repair cells naturally, the faster the whole organism will benefit. It is for these purposes that a separate group of drugs called hepatoprotectors serves. They stimulate the regeneration of affected liver cells, normalize its functioning and protect against the harmful effects of harmful substances.

Read also:

Today, the pharmaceutical market is saturated with similar drugs, both domestic and foreign. Phosphogliv and Essentiale-Forte N are especially popular, and now we will find out which of them is better.

"Essentiale"	Phosphogliv

The preparation is rather unique, first of all, by a high content of essential phospholipids. They are involved in the restoration of cells and the normalization of metabolism. The drug reduces the intensity of the replacement processes of healthy cells with connective tissues.	Active combined hepatoprotector, which includes, in addition to phospholipids, glycyrate. This substance provides the immunomodulatory properties of the drug, inhibiting the development of viruses and stimulating the production of interferon.
Indications and contraindications
It is used for degenerative fatty lesions of the liver, including diabetes, intoxication, cirrhosis, hepatitis various forms, cellular tissue necrosis, psoriasis, hepatic coma. The tool is contraindicated in case of hypersensitivity to the components that make up its composition.	Capsules are prescribed for the treatment of viral hepatitis chronic form and cirrhosis of the liver. The drug is used in complex treatment eczema, psoriasis, neurodermatitis, acute intoxication of the liver and the body as a whole. The drug is not prescribed to children under 12 years of age and pregnant women. During lactation, its use is possible only with the suspension of breastfeeding.
Advantages
Consists exclusively of natural components. This is the first choice for autoimmune liver damage and hepatitis of various nature. It has good performance tolerance for both adults and children. The drug is approved for pregnant and lactating women. Can be used as a preventative or aid in the treatment of psoriasis, radiation and cholelithiasis. Stimulates digestive fermentation. It is used to prevent atherosclerosis, stroke, heart attack by lowering cholesterol levels.	Possibility wide application in the treatment of hepatitis of viral etiology and various pathological liver lesions, including alcoholic, toxic or medicinal. It is used in the complex therapy of neurodermatitis, psoriasis and eczema as an adjuvant. Has practically no side effects and is well tolerated by patients of all ages.
Flaws
Possible side effects in the form of allergies, abdominal pain, diarrhea.	Contraindicated in hypertension. Prevents the removal of fluid from the body. Possible skin reactions in the form of a rash.

What are the analogues?

In addition to the two drugs considered, pharmacy chains offer a large selection of drugs that are analogues of Phosphogliv and Essentiale:

"Heptral" - a hepatoprotector with antidepressant properties, has a neuroprotective, antioxidant, detoxifying effect. Actively stimulates recovery processes in the liver.
"Karsil" - is used both for the regeneration of liver tissues, and for the prevention of pathological changes.
"Hofitol" is a plant hepatoprotector with a choleretic effect. In addition, the drug has a moderate diuretic effect. And the therapeutic effect of the drug is provided by the artichoke leaf extract.

Preparations of the hepatoprotector group are intended for the treatment of liver diseases. They are prescribed to restore the integrity of hepatocytes and activate their work, increase the resistance of liver cells to external damaging factors. Funds based on essential phospholipids, such as Essentiale Forte or Phosphogliv, contain elements that are embedded in the hepatocyte membrane and strengthen it.

Hepatoprotector eliminates disorders of the liver, promotes the restoration of cell membranes, membrane-bound enzyme receptors and systems, cleanses the body of toxins and toxins, improves digestion and metabolism in the body.

The drug is based on essential phospholipids - substances of natural origin, which are the building material of cell membranes of tissues and organs. They are close in structure to the components human body, but contain more polyunsaturated fatty acids necessary for the normal growth, development and functioning of cells.

Phospholipids not only restore the structure of the liver, but also carry cholesterol and neutral fats to places of oxidation, due to which the metabolism of proteins and lipids is normalized.

Reconstructing the cells of the organ, the drug does not eliminate causal factors existing violations of body functions and does not affect the mechanism of hepatic damage.

Indications:

cirrhosis of the liver;
hepatitis in a chronic form;
fatty degeneration of the liver of various origins;
liver damage of a toxic type;
alcoholic hepatitis;
violations of the liver, accompanying other somatic diseases;
toxicosis during pregnancy;
radiation syndrome;
as an aid in the treatment of psoriasis;
pre-, postoperative therapy;
to prevent the recurrence of gallstones.

The drug is contraindicated in persons with individual intolerance to the components that make up the composition.

Can be used to treat children over 12 years of age and weighing more than 43 kg.

There is no sufficient information on the use of Essentiale Forte by pregnant and lactating women, therefore, the use of the drug during pregnancy and lactation is allowed only as prescribed by a doctor in the doses prescribed by him.

The drug is well tolerated, but in some cases it can cause adverse reactions in the form of organ dysfunction. gastrointestinal tract, itching and allergic rashes.

The initial dose of the drug for adults and children over 12 years old - 2 capsules 3 times a day. For the purpose of prevention - 1 capsule 3 times a day. Taken orally with meals, without chewing and drinking a small amount water. The recommended duration of the treatment course is at least 3 months.

As prescribed by the attending physician, the dose and duration of therapy can be changed to optimal levels, taking into account the nature and severity of the disease, as well as individual characteristics patient.

Phosphogliv

Phosphogliv regenerates cell membranes of hepatocytes, improves liver function, eliminates inflammatory processes, promotes the elimination of toxins, has an antioxidant and antiviral effect.

The combined preparation contains essential phospholipids and glycyrrhizic acid, due to which it has a complex effect on the affected liver, eliminating the consequences of negative processes and influencing the mechanism and causes of their occurrence.

Phospholipids, integrating into the structure of cellular and intracellular membranes, reconstruct liver cells, protect hepatocytes from loss of enzymes and other active substances, and normalize lipid and protein metabolism.

Glycyrrhizic acid has anti-inflammatory properties, promotes inhibition of viruses in the liver, increases phagocytosis, stimulates the production of interferons and the activity of natural killer cells that protect the body from foreign microorganisms.

Indications:

steatohepatosis;
steatohepatitis;
toxic, alcoholic, drug-induced liver damage;
liver diseases that occur with diabetes mellitus;
how additional remedy therapy of neurodermatitis, cirrhosis, viral hepatitis, psoriasis, eczema.

The drug is contraindicated in antiphospholipid syndrome and hypersensitivity to the components that make up the composition. The use of Phosphogliv for the treatment of pregnant and lactating women, children under 12 years of age is not recommended due to the lack of sufficient data on efficacy and safety.

While taking the drug, side effects are possible in the form of increased blood pressure, dyspepsia, discomfort in the epigastric region, allergic reactions(skin rash, cough, nasal congestion, conjunctivitis).

Capsules are taken orally during meals, without chewing and drinking plenty of liquid. The recommended regimen for adults and children over 12 years old is 2 pcs. 3 times a day. The average duration of the therapeutic course is 3 months, if necessary, according to the doctor's prescription, it can be increased up to 6 months.

Comparison of drugs

What common

Medicines belong to hepatoprotectors and are prescribed for liver damage. various genesis. They contain the same substance - phospholipids, which are embedded in damaged cell membranes, contributing to their recovery and healthy functioning.

Both drugs have the same form of release: they are produced in the form of capsules, which are taken orally as a whole with meals, and an injection solution.

Not indicated for the treatment of children under 12 years of age.

What is the difference

Unlike Essentiale Forte, Phosphogliv contains an additional component in the form of glycyrrhizic acid, which leads to a complex effect of the drug on the damaged liver and a more pronounced therapeutic effect in relation to not only the negative manifestations of the disease, but also the causes of its occurrence.

Glycyrrhizic acid by chemical composition close to the natural hormone of the adrenal cortex and has anti-allergic, antiviral, immunomodulatory and anti-inflammatory effects. But at large doses and long-term use can cause unwanted side effects.

A more saturated composition of Phosphogliv contributes to more contraindications and an increased risk of allergic reactions.

Essentiale is recommended for use by pregnant women with toxicosis. Its analogue with a complex action is not prescribed during pregnancy and lactation, due to the lack of data on the safety of use in this group of patients.

What is cheaper

Essentiale Forte is made in Germany, Phosphogliv is produced by a Russian manufacturer, which causes a difference in price. Imported hepatoprotector is more expensive than domestic.

Which is better - Essentiale Forte or Phosphogliv

Each of the drugs has its positive and negative sides. The effectiveness of treatment with one or another remedy will depend on the nature and severity of the disease, as well as the age, condition and tolerance of the patient to the components that make up the composition.

To restore the liver

Taking into account the difference in the main active substances, Essentiale Forte is less allergenic and safer, can be used in large doses and during pregnancy, but does not have the necessary effectiveness for the treatment of viral liver diseases.

Phosphogliv contains additional active ingredient, which has antiviral and anti-inflammatory properties, enhances the action of phospholipids, therefore it can be used in the treatment of hepatitis of viral etiology, other severe liver pathologies.

For achievement positive results without the manifestation of side effects, it is better to consult a doctor who will decide on the use of a particular drug, taking into account the medical history and individual indications and contraindications.

Many believe that alcohol abuse is at the heart of liver problems. However, this is not quite true. We absorb pollutants through our air and food every day. Unhealthy diet and medicines also negatively affect the liver. But it is not all that bad. How to effectively support liver regeneration? Which is better - "Phosphogliv" or "Essentiale"?

The liver is one of the most important human organs when it comes to maintaining health. The amount of toxins that are filtered daily through the liver cells from the blood increases steadily throughout our lives. In addition to the body's internal toxins, alcohol, nicotine, drugs and medications of all kinds place a huge burden on the liver.

In addition, intestinal problems, such as bloating, pesticides in food, as well as environmental pollutants - heavy metals in drinking water, and much more, do not add to health.

The sooner you help your liver build cells and regenerate them naturally, the sooner your whole body will benefit. It is for these purposes that a separate group of drugs called hepatoprotectors serves. They stimulate the regeneration of affected liver cells, normalize its functioning and protect against the harmful effects of harmful substances.

Which is better - "Phosphogliv" or "Essentiale"?

"Essentiale"	Phosphogliv

The preparation is rather unique, first of all, by a high content of essential phospholipids. They are involved in the restoration of cells and the normalization of metabolism. The drug reduces the intensity of the replacement processes of healthy cells with connective tissues.	Active combined hepatoprotector, which includes, in addition to phospholipids, glycyrate. This substance provides the immunomodulatory properties of the drug, inhibiting the development of viruses and stimulating the production of interferon.
Indications and contraindications
It is used for degenerative fatty lesions of the liver, including diabetes, intoxication, cirrhosis, hepatitis of various forms, cell tissue necrosis, psoriasis, hepatic coma. The tool is contraindicated in case of hypersensitivity to the components that make up its composition.	Capsules are prescribed for the treatment of chronic viral hepatitis and cirrhosis of the liver. The drug is used in the complex treatment of eczema, psoriasis, neurodermatitis, acute intoxication of the liver and the body as a whole. The drug is not prescribed to children under 12 years of age and pregnant women. During lactation, its use is possible only with the suspension of breastfeeding.
Advantages
Consists exclusively of natural components. This is the first choice for autoimmune liver damage and hepatitis of various nature. It has good tolerability rates in both adults and children. The drug is approved for pregnant and lactating women. It can be used as a prophylactic or adjuvant in the treatment of psoriasis, radiation and cholelithiasis. Stimulates digestive fermentation. It is used to prevent atherosclerosis, stroke, heart attack by lowering cholesterol levels.	The possibility of wide application in the treatment of hepatitis of viral etiology and various pathological lesions of the liver, including alcoholic, toxic or medicinal. It is used in the complex therapy of neurodermatitis, psoriasis and eczema as an adjuvant. It has practically no side effects and is well tolerated by patients of different age categories.
Flaws
Possible side effects in the form of allergies, abdominal pain, diarrhea.	Contraindicated in hypertension. Prevents the removal of fluid from the body. Possible skin reactions in the form of a rash.

What are the analogues?

In addition to the two drugs considered, pharmacy chains offer a large selection of drugs that are analogues of Phosphogliv and Essentiale:

"Geptral" - a hepatoprotector with antidepressant properties, has a neuroprotective, antioxidant, detoxifying effect. Actively stimulates recovery processes in the liver.
"Karsil" - is used both for the regeneration of liver tissues, and for the prevention of pathological changes.
"Hofitol" is a plant hepatoprotector with a choleretic effect. In addition, the drug has a moderate diuretic effect. And the therapeutic effect of the drug is provided by the artichoke leaf extract.

User Reviews

To complete the picture and the final choice, which is better - "Phosphogliv" or "Essentiale", consider the reviews of those who took these drugs:

Snezhana: “After my father began to lose weight rapidly, he was diagnosed with cirrhosis of the liver in initial stage. For us it was just a shock! Have appointed or nominated treatment, as they say, medicines of a heap. Among them is "Essentiale". My father has been taking it for 10 years now with treatment courses of three months with a thirty-day break. His condition is stable, the disease is not progressing, we hope for recovery.”
Larisa: “I got hepatitis C during a blood transfusion during childbirth. Phosphogliv was prescribed for treatment: first intravenous injections and then capsules. Since then, I have been taking this remedy twice a year during periods of spring and autumn exacerbations. Constant monitoring of tests confirms the positive effect of the drug. The disease does not develop, I feel good.”

Each of the proposed drugs has its positive and negative sides. If you say that one of them is better, then you recognize the other as worse, but this is not so. The decision to use a particular drug should be made only by a doctor, taking into account individual indications and contraindications. Be healthy!