In different syringes and each in its place

both are injected only intramuscularly - the solution itself does not need to be diluted in the ass

someone needs to get their brains out! kkb is diluted with a solution! it's a powder. drugs in different days stab in the muscle! for example: the first day - kkb, the second - atf

Is it necessary to pierce Thiotriazoline and Cocarboxylase with diffuse changes in the myocardium?

Good afternoon, dear Victoria Yurievna! Me long time I was worried about discomfort in the heart area (squeezing, tingling, burning, palpitations up to 100, the limbs of the arms began to go numb during sleep or in a bent position, and later the legs), after the ECG, the therapist said that there was some kind of reflux on the heart, you just need to drink sedatives. 6 months ago I was in a sanatorium and, having made an ECG, I was given the conclusion “diffuse myocardial change” and advised to pierce ATP and Carboxylase 1 ampoule - 1 time per day for 10 days, to improve metabolism, and after that, pierce with the same course Thiotriazolin to strengthen the heart muscle, improve oxygen supply, restore heart rhythm, and for the prevention of stroke. But, after 1 ampoule, my inflammation of the trigeminal nerve worsened, but they told me that it was most likely a draft and this drug is not capable of causing such reactions. And so I still pierced for 5 days (5 ampoules), and now after reading more information, I have doubts whether I need this drug? Thanks in advance for your answer!

Hello. signs diffuse changes in the myocardium according to ECG data are not a diagnosis, they can occur with various diseases and require further diagnosis. As for appointments, there is nothing wrong with them. Such metabolic therapy is useful both for pre-existing pathology and for prevention. Treatment could not provoke inflammation of the trigeminal nerve. Another thing is that in the presence of heart disease, such a course is not enough, so continue the examination.

"Cocarboxylase": instructions for use, reviews

Many people who have problems with acid-base balance, in particular those who suffer from diabetes mellitus or cardiovascular diseases, are familiar with Cocarboxylase, as it is a vitamin-like drug.

metabolic acidosis

Throughout life, the human body is formed a large number of all kinds of acids. He gets rid of their excess through urine, sweating and Airways. This happens if the metabolism is not disturbed, because otherwise they will accumulate in the blood and negatively affect the connective and nervous tissues of a person. This process is called metabolic acidosis and often occurs when the body is deficient in vitamin B1. This pathology leads to dangerous consequences: increased blood clotting, myocardial infarction, peripheral thrombosis, hyperglycemic coma and death. For this reason, specialists who have discovered problems with acid-base balance in a patient prescribe pharmacological agent"Cocarboxylase". Instructions for use are presented below.

Pharmacological abilities

Cocarboxylase is a non-protein organic enzyme that is directly involved in the neuro-reflex processes of the body, lowers the amount of lactic, pyruvic and alpha-ketoglutaric acids.

His positive action are aimed at carbohydrate metabolism and providing tissues with energy. Deficiency of cocarboxylase leads to a deterioration in the absorption of glucose, the functioning of the heart muscles, and the metabolism of nerve tissues. This can lead to the fact that a person will be susceptible to diseases such as acidosis, diabetes mellitus, neurocircular dystonia, heart pathologies, etc. In turn, the drug "Cocarboxylase" normalizes acid-base and energy metabolism. This, in turn, contributes to the antitoxic and anti-ischemic action.

"Cocarboxylase": instructions for use and indications

The drug is prescribed to a patient who needs to stabilize the metabolism during respiratory, hepatic, cardiovascular and renal insufficiency. Ischemic heart disease, pre- and post-infarction conditions that may occur due to high level acidity in the blood, the coenzyme drug "Cocarboxylase", analogues of which are also able to deal with similar problems, helps to normalize a person's condition. Often it is prescribed to people suffering from chronic alcoholism and poisoning of any form, including medication.

The drug "Cocarboxylase", instructions for use of which are below, is also prescribed for infectious diseases:

Peripheral neuritis and multiple sclerosis are also no exception. Even in pediatric practice, medicine has found its place. It is used during pregnancy if there is severe toxicosis or fetal hypoxia.

"Cocarboxylase" - these are ampoules with powder that will be used for injections to the patient. For children, the drug is administered intramuscularly, subcutaneously, or in some cases sublingually under the tongue. The drug "Cocarboxylase" intravenously is used only for adults once a day.

Children of any age who have not reached eight years of age are administered 25 mg of Cocarboxylase. Instructions for use for adults and children after eight years are somewhat different - mg. The timing of drug treatment is set by the doctor individually for each patient. It all depends on the degree and neglect of the disease.

"Cocarboxylase": indications during pregnancy

The fetus, which is completely in the body healthy woman, gets everything essential vitamins and trace elements for normal development. But if a pregnant woman has serious complications, such as severe toxicosis in the last months of pregnancy, eclampsia, impaired transport of thiamine, convulsions, then "Cocarboxylase" is prescribed expectant mother before being installed true reason occurrence of some disease. Also, the drug is allowed for use by pregnant women with diabetes.

Side effects and contraindications

There are practically no side effects from the use of the drug, with the exception of intolerance to the active substance itself (cocarboxylase). Instructions for use focuses on the fact that after the introduction of this tool, serious side effects was not noted.

Cocarboxylase is highly effective drug, but before using it in treatment, it should be without fail consult with your doctor.

"Cocarboxylase-Forte" - what is it and how is it different?

Many people, having fallen ill with a particular disease, visiting pharmacies, ask for something that works, but without the need for injections. There is nothing strange about this, because an injection is always an additional and unwanted expense. In addition, this is very inconvenient, since not everyone can give themselves an injection at home or ask relatives about it. After all, if it is done incorrectly, then discomfort and discomfort in the injection area are guaranteed. Therefore, the drug "Cocarboxylase-Forte" in tablets was created.

Cocarboxylase is not the only component that is part of the drug. It also contains the amino acids glycerol and magnesium ions. They significantly improve the activity of cocarboxylase. Magnesium improves absorption and metabolism, while glycerin provides a mild effect, improving and normalizing sleep.

The drug "Cocarboxylase", reviews of which are very positive, does not differ much from "Cocarboxylase-Forte" in terms of pharmacological actions. It is also successfully used in violation acid-base balance and for the prevention of complications in diabetes mellitus.

"Cocarboxylase-Forte": clinical trials

Experts assure that "Cocarboxylase-Forte" is very effective for use in complex therapy in patients suffering from diabetes mellitus, coronary heart disease, dystonia, metabolic disorders, as well as for preventing the development of complications in the cardiovascular system.

"Cocarboxylase-Forte": advantages

This drug is this moment more often purchased than "Cocarboxylase" for injection, due to the advantage of using without discomfort and the absence of additional costs in the form of syringes, water for injection, etc.

This is especially important for children who suffer from the above diseases. After all, the fact that they have undergone such an ailment already gives them a lot of trouble, and it is very important to provide them with at least a comfortable treatment without the use of needles.

Method of application of the drug and its contraindications

"Cocarboxylase-Forte" is not assigned to those people who have an increased sensitivity to the components. It is also not recommended for pregnant women. Medicine not prescribed to children who have not reached twelve years of age.

Patients with diabetes, taking Cocarboxylase-Forte, should monitor their blood sugar levels daily.

The dosage is always set by the attending physician. Adults and children who have reached the age of twelve, take one tablet under the tongue until completely dissolved, 3-4 times a day. It is also intended to be used orally 15 minutes before meals 3-4 times a day, you need to take a pill a small amount water. The course of treatment usually lasts no more than a month.

Side effects of "Cocarboxylase-Forte"

According to experts, the drug is well tolerated by the body. Side effects that may occur are associated either with an overdose or with individual intolerance to the components. Possible manifestations of urticaria, rash, redness on the skin, itching, nausea and headaches. If you feel these symptoms, you should contact your doctor, who, if possible, will reduce the dosage or provide an opportunity to use another drug if a decrease in the amount of Cacorboxylase-Forte does not help get rid of discomfort.

One way or another, no matter what drug you choose, before buying it, you should consult with your doctor and discuss with him all the questions that you may be concerned about.

If there is a need to purchase "Cocarboxylase" for a child, then specify the possibility of using the drug without the use of injections, if this is provided for in your case and the age of your child allows it. Pregnant women should also be especially careful when using the drug in any form.

"Cocarboxylase": indications for use

The use of Cocarboxylase reduces the concentration of pyruvic and lactic acid, improves glucose processing, has a positive effect on the trophism of nerve tissues, and normalizes the functionality of the cardiovascular system. If the body is deficient in this substance, the level of pyruvic acid in the blood rises, which can lead to the development of acidosis.

Release form and composition

Indications for use and price

The average price of cocarboxylase in ampoules and vials per ruble. You can buy cocarboxylase in pharmacies.

The use of cocarboxylase and indications:

• Diabetic, metabolic, respiratory acidosis (failures of the acid-base state, they manifest as low rate blood pH level and bicarbonate concentration below normal.
• Hypoglycemia, hyperglycemia (high and low level Sahara).
• Pathological processes taking place in the body, accompanied by disorders of carbohydrate metabolism. Diseases of this group can be hereditary and acquired. The most common are galactosemia, generalized glycogenosis, and diabetes mellitus.
• Liver, respiratory, renal, heart failure. Relevant for acute and chronic form diseases.
• Postinfarction cardiosclerosis - as a component complex treatment cardiovascular diseases, for more details see the link).
• Hepatic coma.
• diabetic coma. (Very often occurs in diabetes mellitus as a result of violations of the norm of sugar in the blood)
• chronic alcoholism and acute poisoning alcohol.
• Poisoning with drugs of the barbiturate group, foxglove.
• Paratyphoid, scarlet fever, diphtheria, typhoid - as a component of complex therapy.
• Multiple sclerosis, peripheral neuropathy.
• Hypoxic perinatal encephalopathy, pneumonia, sepsis, respiratory failure in newborns.
• Conditions accompanied by acidosis and hypoxia.

Instructions for use and doses

Instructions for use of cocarboxylase injections and powders for solution preparation:

• The drug Cocarboxylase is administered subcutaneously, intramuscularly or intravenously. The proportion of the drug is prescribed individually, based on the anamnesis, the patient's condition and the severity of the disease.
• For adults, the drug is administered once - 50/100 mg. If necessary, as in the case of the development of a diabetic coma - once every two to three hours. In the future, the prescribed therapy is maintained - 50 mg daily.
• With stable circulatory failure - strictly 50 mg two to three times daily, before taking digitalis preparations. The course of procedures is a day.
• In diabetes mellitus - mg daily with a duration of 5-10 days, without stopping standard antidiabetic therapy.
• At acute form kidney or liver failure, burns, intoxication hmg three times a day.
• With multiple sclerosis and peripheral neuritis 50/100 mg daily supra.

Contraindications

• High sensitivity to the drug.
• Hypovitaminosis of Vitamin B1.
• Avitaminosis of Vitamin B1.

During pregnancy and children

For children, the drug is administered intramuscularly or subcutaneously, except for newborn babies. They are administered sublingually.

Cocarboxylase hydrochloride intramuscularly good support for the heart

Today, I got a kick out of writing drug reviews. It's already night in the yard, but I can't stop everything))).

This time, I'll tell you about the drug that helped me restore my heart and maintain my body's strength after childbirth. When you're on your feet all day, postpartum depression, and then there are two babies at once, it is very difficult for my motor. Therefore, when the arrhythmia began and the body began to tremble from lack of sleep (especially the nightly pumping of milk), I asked my mother to give me Cocarboxylase hydrochloride injections intramuscularly.

Fortunately, my mother is a doctor and for injections, I don’t have to go to the hospital.

My course of treatment was simple: one day I was injected with an ATP drug (also to support the heart).

On the second day, Cocarboxylase hydrochloride was injected.

By alternating these drugs, my heart received a kind of "vitamin" that gave me the strength to take care of children around the clock.

The package contains 10 bottles of cocarboxylase + 10 bottles of solvents for intramuscular injection.

Unfortunately, I can’t show a photo of ATP, since those injections are over. And a package of cocarboxylase, my mother bought more. Part of the instructions for use, I will show in the photo. But it is clearly written there that in case of violations of the heart and poor carbohydrate metabolism, you can inject this drug. At that time, I already had tachycardia, since I had not slept normally for almost half a year. And my husband didn't help either. Mode of application this drug, I posted sequentially. For those who are interested, you can read how to dilute injections before use.

My course of treatment, to restore the rhythm of the heart and improve its work, was 20 days.

10 days ATP preparation + 10 days cocarboxylase preparation.

The injections are very painful, especially cocarboxylase. It feels like a bee stung. At the end of the treatment, I was already crying from the injections.

But then how my heart worked. How new! Arrhythmia, tachycardia disappeared, I felt a surge of strength and energy. I don't regret going through all this. Even the circles under the eyes are gone))).

The price of the drug for 10 ampoules is 70 hryvnia, or 300 rubles.

The entire course of treatment cost me 150 hryvnia (together with ATP).

Cocarboxylase - solution for injection

Many pharmaceutical companies are bringing to market the drug Cocarboxylase, which belongs to simple vitamins group B. Each ampoule contains 0.05 grams of the main component. Also in the package there is an additional ampoule with a solution for diluting the powder. The drug is available in powder for injection, which will be dissolved before direct administration. The package contains 5 or 10 ampoules.

Pharmacological properties

This tool provides next action on the body:

• coenzyme;
• takes part, together with sodium and proteins, in accelerating carboxylation and decarboxylation;
• accelerates the formation of acetyl-coenzyme A, which contributes to the normalization of carbohydrate metabolism.

Pharmacodynamics

At parenteral administration component of the drug is rapidly and completely absorbed mainly in thin department intestines and duodenum. Only 11 hours after use, cocarboxylase is excreted from the body. During the study of the drug, it was possible to find out that it is found in all tissues, and especially in the liver, heart and brain.

Cocarboxylase helps glucose assimilate and normal functioning of the CCC organs. Also, the main component improves tissue nutrition. Its lack provokes the accumulation of acids, while acidosis develops and its consequence is an acidotic coma. Most often, Cocarboxylase is recommended in the presence of pathologies during which endogenous deficiency is observed.

Pharmacokinetics

When it enters the bloodstream, the main component of the drug is picked up by red blood cells and distributed throughout the body in the form of thiamine diphosphate. Metabolic processes occur in the liver, and the drug is excreted with the help of the kidneys with urine.

Indications

Doctors prescribe Cocarboxylase if the patient has such diseases:

• acidosis of diabetic, metabolic and respiratory forms;
• heart failure;
• violation of the kidneys;
• breathing problems;
• cardiosclerosis that occurred after a heart attack;
• violation of metabolic processes of carbohydrates;
• heart attack;
• angina pectoris in an unstable form;
• coronary heart disease, which occurs in a chronic form;
• diabetic and hepatic coma;
• acute alcohol poisoning and its consequences;
• a history of chronic alcoholism;
• multiple sclerosis;
• various infectious diseases;
• sepsis followed by hypoxia and acidosis.

Contraindications

The only contraindication to the use of the drug is the presence of an allergic reaction to its main or auxiliary components.

Side effects

In the course of clinical studies, it was possible to find out that Cocarboxylase can provoke the appearance of negative reactions when using a dose that exceeds 0.5 grams per day. Patients complain about the development of such sensations:

• loss of appetite;
• pain in the stomach;
• be sick;
• there is anxiety and fear;
• sleep is disturbed;
• the skin develops a rash, hives and itching.

With intramuscular administration of the drug, such adverse reactions that are local:

Dosage

The instruction describes such ways of administering the drug:

Only a doctor has the right to prescribe the dose, frequency of administration and course of therapy, which depends on the state of health of each individual patient.

The average dose for an adult is 1-2 ampoules per day. The doctor may decide to administer the drug with a break that does not exceed only a few hours. Most often this happens when the patient has a diagnosis of "diabetic coma", and after the condition improves, it is enough to use 50 milligrams per day.

Circulatory disorders

Dose of Cocarboxylase in this disease: 1 ampoule up to 3 times a day. The duration of therapy can range from 14 days to 1 month.

Diabetes

Patients with this pathology need to administer the drug at a dose of 100-1000 milligrams per day for up to 10 days without interruption. Along with this, it is necessary to take other medicines for diabetes.

In the presence of acute renal and hepatic insufficiency in the first few days, Cocarboxylase is injected into a vein 1-3 ampoules 3 times a day. You can also use the drug drip. To do this, dissolve the drug in 400 ml of a 5% glucose solution.

Neuritis

In this disease, the drug is administered intramuscularly, 1-2 ampoules per day. The course of treatment is from 30 to 45 days.

children

Children who have not reached 3 months can be administered 25 mg of Cocarboxylase subcutaneously or intramuscularly. Patients from 3 months to 7 years of age are prescribed mg per day, and from 8 to 18 years, mg can be used.

Pregnant

If the doctor takes responsibility and decides to prescribe Cocarboxylase to a pregnant woman, then she is diluted with glucose and vitamin C and administered intravenously. The duration of therapy is from 10 days to two months. The main indications for the use of the drug in given period is:

Overdose

If you exceed the dose prescribed by your doctor, you may experience the following symptoms:

• heart rate increases;
• be sick;
• gagging;
• headache;
• feeling weak and tired;
• muscles spasm;
• disruption of the cardiovascular system;
• sweating increases;
• shortness of breath and allergic reactions appear.

With the development of one or more symptoms, it is necessary to stop the administration of the drug and contact the medical institution where doctors can provide first aid and provide symptomatic overdose therapy.

drug interaction

Cocarboxylase is very actively combined with various drugs and biologically active substances. Consider the main interactions:

1. With antidepressants - there is an increase in activity.
2. B vitamins contribute to the activation of therapeutic effects.
3. Digoxin - provokes a decrease in the ability of the myocardiocyte to absorb the active substance and its metabolites.

It is forbidden to combine Cocarboxylase with drugs that have an alkaline or neutral reaction.

Application features

During the complex treatment of any disease, it is worth considering the possibility of the main component to activate the cardiotonic activity of drugs from the group of cardiac glycosides. In the presence of atrial fibrillation, intravenous administration of the drug is prohibited.

During pregnancy

For ethical reasons clinical researches on the topic of the effect of cocarboxylase on pregnant, lactating women and their babies have not been conducted. For this reason, it is not recommended to use this drug during this period.

Reaction

How Cocarboxylase affects the reaction rate while driving a car or working with other mechanisms is unknown, because manufacturers have not studied this issue.

Acquisition

You can buy Cocarboxylase in injections by providing a prescription from your doctor, which will indicate the required dose and course of treatment.

Storage

To maintain the therapeutic effect, you must adhere to the following rules:

• the temperature in the room where the drug is located should not exceed 25 degrees;
• humidity must be kept low;
• ampoules should be kept away from children and direct sun rays.

The expiration date is indicated on the packaging and should not exceed 36 months. After the expiration of this period, the ampoules must be disposed of.

Analogues

Instructions for the use of Cocarboxylase injections indicate the presence of such analogues:

Price

The cost of the drug directly depends on the manufacturer of the drug and the point retail. The average price for 5 ampoules of Cocarboxylase is at the level of 50 rubles, which makes the drug affordable for different segments of the population.

Cocarboxylase - instructions for use, analogs, testimonials and release forms (injections in ampoules for intravenous and intramuscular injections of hydrochloride) for the treatment of acidosis and coma in adults, children and pregnancy. Compound

In this article, you can read the instructions for using the drug Cocarboxylase. Reviews of site visitors - consumers are presented this medicine, as well as the opinions of medical specialists on the use of Cocarboxylase in their practice. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Cocarboxylase analogues in the presence of existing structural analogues. Use for the treatment of acidosis, diabetic coma and liver and kidney failure in adults, children, and pregnancy and lactation. The composition of the drug.

Cocarboxylase is a coenzyme that is formed in the body from thiamine. It has a metabolic effect, activates tissue metabolism. In the body, it is phosphorylated with the formation of mono-, di- and triphosphoric esters; cocarboxylase is part of the enzymes that catalyze the carboxylation and decarboxylation of keto acids, pyruvic acid, promotes the formation of acetyl-coenzyme A, which determines its participation in carbohydrate metabolism. Participation in the pentose cycle indirectly promotes the synthesis of nucleic acids, proteins and lipids.

Improves the absorption of glucose, trophism of the nervous tissue, contributes to the normalization of the functions of the cardiovascular system.

Deficiency of cocarboxylase causes an increase in the level of pyruvic and lactic acids in the blood, which leads to acidosis and acidotic coma.

Cocarboxylase hydrochloride + excipients.

• metabolic acidosis;
• hyperglycemic coma and acidosis in diabetes mellitus;
• liver failure;
• kidney failure;
• respiratory acidosis in chronic, cardiopulmonary insufficiency;
• respiratory failure;
• chronic circulatory failure;
• myocardial infarction and postinfarction cardiosclerosis (as part of complex therapy);
• acute alcohol poisoning;
• chronic alcoholism;
• poisoning with foxglove preparations, barbiturates;
• intoxication with infectious diseases: diphtheria, scarlet fever, typhus and paratyphoid fever (in complex therapy);
• peripheral neuritis.

In children during the neonatal period:

• perinatal hypoxic encephalopathy;
• respiratory failure;
• pneumonia;
• sepsis;
• hypoxia;
• acidosis.

Lyophilisate for solution preparation for intravenous and intramuscular administration (injections in ampoules for injections).

Other dosage forms, whether it be pills or suppositories, does not exist.

Instructions for use and scheme of use

Adults are administered intramuscularly or intravenously. The dose is mg per day. In diabetes mellitus (acidosis, coma), the daily dose may be 0.1-1 g. The frequency and duration of use depends on the indications.

Children - in / m, in / in (drip (dropper) or jet), newborns - sublingually. Children under 3 months - 25 mg per day, from 4 months to 7 years mg per day, from 8 to 18 years mg per day. Duration of treatment - from 3-7 to 15 days.

• allergic reactions (urticaria, itching);
• hyperemia, itching and swelling at the injection site.

• hypersensitivity to cocarboxylase.

Use during pregnancy and lactation

Regarding the efficacy and safety of using cocarboxylase during pregnancy, medical research have not yet been carried out. Therefore, there are no reliable data on the contraindication of cocarboxylase at this time. A doctor's consultation is required.

Application is possible according to the dosing regimen.

Enhances the cardiotonic effect of cardiac glycosides and improves their tolerance.

Analogues of the drug Cocarboxylase

Structural analogues for the active substance:

• Cocarboxylase Improv;
• Cocarboxylase Ferein;
• Cocarboxylase Ellar;
• Cocarboxylase hydrochloride.

Analogues for pharmacological group(means for the treatment of acidosis):

• Alpha D3 Teva;
• Dimephosphone;
• Kalinor;
• Quintasol;
• sodium bicarbonate;
• Compound sodium lactate;
• Stylamine;
• Trometamol N.

Cocarboxylase

Description current as of 01/27/2015

• Latin name: Cocarboxylase
• ATX code: A11DA01
• Active ingredient: Cocarboxylase (Cocarboxylase)
• Manufacturer: Microgen NPO FSUE, DECO company, Moskhimfarmpreparaty im. N.A. Semashko (Russia), Jelfa S.A. (Poland)

Compound

One ampoule with lyophilisate for solution preparation includes cocarboxylase hydrochloride 50 mg and solvent (sodium acetate solution) 2 ml.

Release form

The powder from which it is prepared injection solution, supplied in 50 ml ampoules, quantity - 5 pieces in one package.

pharmachologic effect

Cocarboxylase has a coenzymatic effect, as it is a coenzyme of thiamine. Together with protein and magnesium ions, it catalyzes the carboxylation and decarboxylation of alpha-keto acids, and also stimulates the formation of acetyl-coenzyme A, thereby normalizing carbohydrate metabolism.

Pharmacodynamics and Pharmacokinetics

Cocarboxylase is characterized by rapid and absolute absorption when administered parenterally. Absorption mainly takes place in small intestine and duodenum. Clearance - about 11 hours. The active substance of the drug almost completely penetrates into all tissues, but its highest concentration is observed in the liver, kidneys, brain and heart.

Transportation in the blood occurs with the help of erythrocytes, which contain about 80% total number cocarboxylase in the form of thiamine diphosphate. Metabolism active substance carried out in the liver. The drug is excreted from the body with urine in an amount depending on the dose taken.

Cocarboxylase (Cocarboxylasum) is an active form of vitamin B1, which has a metabolic effect by activating tissue metabolism. Phosphorylated in the body, forming mono-, di- and triphosphoric esters. This substance belongs to the group of enzymes that catalyze the carboxylation and decarboxylation of keto acids, pyruvic acid, and also stimulates the formation of acetyl-coenzyme A, due to which it participates in carbohydrate metabolism.

The drug promotes the absorption of glucose and normalizes the functions of the cardiovascular system. In addition, the substance improves tissue trophism, and with its deficiency, an increase in the content of pyruvic acid and lactic acid in the blood occurs, which can provoke the development of acidosis and ultimately lead to acidotic coma.

This drug is prescribed for diseases accompanied by endogenous deficiency of cocarboxylase in combination with vitamin B.

Indications for use Cocarboxylase

The described drug is prescribed for:

Contraindications

Individual intolerance to the active substance.

Side effects

Cocarboxylase has a side effect on the body after a dose exceeding 500 mg per day. Manifest side effects in the form of the following reactions:

Also, side effects can occur in the area of ​​​​administration of the drug in the form of:

Instructions for use Cocarboxylase

This drug is given in three ways:

The dosage is prescribed by the doctor on an individual basis, depending on the patient's disease and his current condition.

Cocarboxylase, instructions for use

The dosage of the drug depends on the indications for the use of Cocarboxylase. Adults intramuscularly administered a milligram of the drug per day. At the discretion of the doctor, the dose may be repeated with a difference of two hours. This dose is usually increased with diabetic coma with a further transition to maintenance therapy with a dosage of 50 milligrams per day.

Patients with circulatory failure, the drug is prescribed for admission at a dosage of 50 milligrams per day with a frequency of two or three times. The course of treatment can be from two weeks to one month.

For patients with diabetes, the drug is administered intravenously at a dosage of 100 to 1000 milligrams per day for five to ten days. At the same time, conventional antidiabetic therapy does not stop.

Patients with acute hepatic and kidney failure the drug is administered intravenously at a dosage of 50 milligrams to 150 milligrams three times a day, or the drug is prescribed drip at a dosage of 100 to 300 milligrams per day with a preliminary dissolution of 5% glucose solution in 400 milligrams.

Patients with peripheral neuritis are prescribed this drug at a dosage of 50 to 100 milligrams per day intramuscularly. The duration of treatment can be 1-1.5 months.

For children up to three months, the medicine is prescribed in the form of subcutaneous or intramuscular injections in a dosage - 25 milligrams a day. For children older than 3 months and up to 7 years, the drug is administered at a dosage of 25 to 50 milligrams per day. For children from 8 to 18 years of age, the drug is administered at a dose of 50 to 100 milligrams per day.

Cocarboxylase during pregnancy is prescribed in a course - 10 days, 50 milligrams per day. The powder dissolves in twenty milligrams of glucose. the injection is given in / in in combination with ascorbic acid in the form of a solution.

During pregnancy, Cocarboxylase is prescribed for fetal hypoxia, as well as in conjunction with complex therapy in the treatment of toxicosis.

Overdose

If the dose prescribed by the doctor is exceeded, overdose symptoms may appear in the form of:

If symptoms of an overdose appear, the drug is canceled and mandatory symptomatic treatment is carried out.

Interaction with other drugs

Cocarboxylase interacts effectively with a number of medicines and biologically active substances:

• antidepressants in combination with the drug - increased action;
• vitamins of group B simultaneous reception of this drug, the effect of vitamins is enhanced;
• digoxin - the ability of myocardiocytes to absorb the active substance of the drug and its metabolites decreases;
• the use of this drug in combination with solutions with an alkaline or neutral reaction is not recommended.

Terms of sale

The drug is dispensed in pharmacies only by prescription.

Storage conditions

You can store the drug at a temperature not exceeding 25C Celsius in a dry and protected from direct sunlight place.

Best before date

The shelf life of the drug is 3 years. It is not recommended to use the medicinal product after the expiration date.

Cocarboxylase analogs

• Cocarboxylase Improv - is a coenzyme that is formed in the body from thiamine;
• Cocarboxylase Ferein is a complete analogue of the described drug, which has an identical effect on the body;
• Cocarboxylase Ellar;
• Cocarboxylases Hydrochloride is a coenzyme of enzymes involved in the metabolism of carbohydrates.

Cocarboxylase is a drug that has a metabolic effect and activates tissue metabolism.

Pharmacological action of cocarboxylase

Cocarboxylase is a coenzyme of enzymes that are involved in the metabolism of carbohydrates. Exogenous cocarboxylase is formed during the metabolism of thiamine.

The drug takes an active part in the processes of decarboxylation of alpha-keto acids. In addition, the drug affects the pentose phosphate pathway of glucose breakdown. Cocarboxylase improves the absorption of glucose, while reducing the level of lactic acid in the body, improves the trophism of the tissues of the peripheral, as well as the central nervous system. In addition, the drug affects the functioning of the cardiovascular system.

According to the instructions, Cocarboxylase is used to treat hypo- and vitamin deficiency of vitamin B1. The drug is excreted from the body by the kidneys.

Method of application and dosage

The drug is intended for the preparation of a solution for parenteral use. According to the instructions, Cocarboxylase must be diluted in 2 milliliters of water for injection. Dissolve the drug should be immediately before injection.

The solution for injection can be administered in several ways: intramuscularly, subcutaneously and intravenously. The duration of treatment and doses are prescribed individually for each patient.

• According to the instructions, adults are prescribed 50-100 milligrams of intramuscular injection once a day.
• If an adult has serious condition, experts prescribe 50-100 milligrams every 2 hours. Injections are given intramuscularly. After that, you need to switch to a maintenance dose - 50-100 milligrams.
• It is advisable to use Cocarboxylase in children under 3 months of age as a subcutaneous injection of the drug. Dose - 25 milligrams 1 time per day.
• For children aged 4 months to 7 years, experts prescribe subcutaneous or intramuscular injection solution of 25-50 milligrams 1 time per day.
• For children over 8 years of age, it is recommended to administer intramuscularly 50-100 milligrams of the drug 1 time per day.

If necessary, experts can share daily dose Cocarboxylases for two injections.

Indications for use

The drug is prescribed to patients who suffer from hepatic, renal failure, hepatic coma. In addition, Cocarboxylase is prescribed as a therapy for precoma.

Cocarboxylase should be used in patients who have acidosis due to diabetes mellitus, as well as people suffering from respiratory acidosis with pulmonary heart failure.

The drug is indicated for multiple sclerosis, with heart disease, with atrial fibrillation, with paroxysmal tachycardia. Cocarboxylase is also prescribed for neuritis, as well as for pathologies associated with impaired carbohydrate metabolism.

Application during pregnancy

Cocarboxylase during pregnancy is allowed to be prescribed if the expected benefit to the woman significantly outweighs the potential risks to the child. If it is necessary to use the drug during lactation, you should consult a specialist and decide on the interruption of breastfeeding.

Cocarboxylase during pregnancy, if there are pathologies in the development of the fetus, it is strictly forbidden to prescribe.

Contraindications

The drug should not be prescribed for hypersensitivity to cocarboxylase hydrochloride. According to reviews, Cocarboxylase can cause allergic reactions on the skin, including itching and redness. The formation of urticaria is not excluded.

The drug should not be administered to patients with atrial fibrillation. According to reviews, Cocarboxylase can cause redness on the skin, itching and swelling of the tissues at the injection site.

Overdose

In case of an overdose of the drug, the severity of side effects may increase, and disorders of the respiratory or cardiovascular systems may also occur.

According to reviews, Cocarboxylase does not have a specific antidote. In case of an overdose, the drug should be discontinued and symptomatic therapy should be carried out, as well as measures to maintain the functions of the respiratory and cardiovascular systems.

Interaction with other drugs

According to reviews, Cocarboxylase, when combined, enhances the therapeutic effects of cardiac glycosides.

According to the instructions, mixing the drug in one syringe with other drugs is strictly prohibited. It is permissible to use only the solvent that is in the box along with the drug.

Terms and conditions of storage

The shelf life of the medicinal product is 3 years. After the solution has been prepared, it must be used immediately. According to reviews, Cocarboxylase should be stored away from children, in a dry and dark place.

It is necessary to store the drug at a temperature not exceeding 25 degrees Celsius.

Compound

One bottle of powder contains: cocarboxylase hydrochloride - 50 milligrams and excipients.

One ampoule with a solvent contains: water for injection - 2 milligrams.

Result: positive feedback

16 +

helped me

Benefits: really helps

Cons: didn't find

Cocarboxylase fit perfectly. I learned about all the "charms" of arrhythmia about five years ago, well, maybe a little more. No matter how they treated me, they prescribed riboxin, and the vaunted mildronat, but everything was like a dead poultice. My heart was still pounding, I didn’t even feel any relief, especially after Riboxin. After mildronat, I also became irritable. And this time the doctor advised Cocarboxylase. They made ten injections and the arrhythmia practically ceased to disturb, and if there were seizures, then she endured them much easier, one might say imperceptibly. In short, I felt like a different person. And most importantly, there were no side effects after Cocarboxylase.

Result: negative feedback

Proven excellent medicine

Benefits: The drug really helps

Cons: Slightly painful injections

Very good medicine for diabetes and heart vascular diseases especially with arrhythmias. I tried it on myself since ancient Soviet times and still using it. Effectively removes acidosis and normalizes the rhythm of the heart, gives energy to the whole body. Do not believe those who say that this drug is not effective. It's just that now there is commercial propaganda in order to wash out cheap drugs from the market so that people would buy expensive drugs.

Result: positive feedback

Improves metabolism

Benefits: effective, safe for pregnant women

Disadvantages: you have to put injections

This drug was prescribed to me during pregnancy, motivating its appointment by the fact that it improves metabolism and normalizes the work of the heart. The drug is produced in the form of a powder for injection, which did not please me at all. I hate injections. But for the sake of their health and the health of the baby had to endure. It must be said that no visible effect I have not noticed. The analyzes improved, but the state of health remained the same as it was. Is that the pressure now rises less frequently. Of my own free will, I would not take this drug, but the analysis of faith is more than personal feelings ... So yes, it can be called good.

Result: positive feedback

Painful but necessary injections

Benefits: Improves heart function and blood pressure

Cons: Painful injections

After 30 years, my heart began to tingle periodically, my blood pressure increased and my pulse quickened. I turned to a cardiologist, no special problems were identified, but for the prevention and strengthening of the heart muscle, 10 injections of Cocarboxylase were injected intramuscularly. Since then former problems with pressure and heart is not observed, I feel great. Only to maintain the body I do such injections annually at one course. This remedy is like a vitamin for the heart. The only bad thing about these injections is that they are very painful. They can also be injected intravenously, they say it doesn’t hurt so much, but I’m just very afraid of such injections, so it’s easier for me intramuscularly.

Result: positive feedback

Proven medicine

Advantages: Cheap, proven, very effective drug.

Cons: The injections are quite painful.

During the winter session, I developed a neurosis, which was accompanied by interruptions in heart rate and tachycardia, which disturbed sleep. The local therapist did not find serious problems and prescribed a course of 12 injections of Cocarboxylase to maintain the heart and nervous system. The only thing I didn't like was the pain at the moment of injection. I have no other complaints, on the contrary, after the course, I clearly felt an improvement in my condition: I became calmer, my sleep returned to normal, tachycardia disappeared, acidosis disappeared, in general, according to others, I began to look healthier. In addition, it became somehow easier to endure physical activity.

Result: positive feedback

It hurts a lot, but good effect

Pros: Inexpensive, effective

Cons: Causes extreme pain.

It was prescribed as part of complex therapy for the treatment of CHF. I was given injections for two weeks, it was a nightmare. Injections of Cocarboxylase are painful to the point of impossibility, during the injection it stings and pricks strongly, as if acid is being injected, after the injection the leg is taken away, the pain radiates to calf muscle and waist. I can’t walk for about half an hour or even an hour. The injections do not dissolve well, so painful bumps form on the buttocks. But the result is worth the pain, because my shortness of breath subsided already in the second week of treatment, and after completing the course, I could breathe deeply and climb stairs without having to stop through each floor. This effect lasts for two or three months, then I have to be treated again. It is painful, but inexpensive (injections cost about a hundred rubles), so Cocarboxylase can and should be used as maintenance therapy.

Cocarboxylase is the phosphate ester of thiamine. It has many synonyms, for example: Cotiamine, Berolase, etc. Vitamin B entering the patient's body is phosphorylated into a coenzyme that has a therapeutic effect.

On Latin the drug has several names: Cocarboxylasum, B-Neuran, Cocarbosyl, Cocarboxylase.

ATX

The anatomical and therapeutic characteristic corresponds to the code A11DA01.

Forms of release and composition

The medicine is produced in several forms:

• powder for solution preparation (0.05 g ampoules, 2 ml solvent);
• lyophilizate for intramuscular injection;
• dried substance for intravenous administration(ampoules of 0.025 and 0.005 g, solvent 2 ml each).

There are 10 ampoules in a pack.

pharmachologic effect

The drug activates the formation of nucleotides, affects the metabolic processes in the body, improves blood circulation in coronary vessels. It helps lower blood cholesterol levels, reduces the risk of atherosclerosis and heart disease.

Pharmacokinetics

The basis of the drug is active substance in the form of a porous, dry mass with a slight odor. The lyophilizate is easily soluble in water. Thiamine coenzyme is adsorbed in the digestive tract.

Of great importance is the process of drug metabolism in the liver. Once in the kidneys, the drug is excreted in the urine in small quantities. The drug is a vitamin of group B, affects the energy balance in the myocardium, protects the kidneys from ischemia during surgical intervention. The lack of coenzyme causes the development of acidosis.

Why are they prescribed

The drug has a beneficial effect on the condition of a patient who has had a myocardial infarction, reduces acidosis, and restores homeostasis. In patients treated with the drug, manifestations of heart failure decrease, tolerance to physical activity increases.

For the treatment of coronary heart disease, the patient is prescribed a metabolite of vitamin B1, but its decomposition occurs within a few minutes after the injection.

Among the indications for prescribing medication, the following conditions are distinguished:

• diabetes;
• chronic respiratory failure;
• to whom;
• arrhythmia;
• multiple sclerosis;
• neuritis;
• eclampsia;
• sepsis;
• acidosis in newborns;
• endocrine disorders.

The drug is used as an antioxidant for the treatment of patients with early period ischemic stroke.

The drug takes part in the following processes:

• promotes the conversion of lactic acid into a pyruvic chemical compound;
• participates in the decarboxylation reaction;
• eliminates metabolic acidosis.

The drug is indicated for patients with diabetes mellitus, since the remedy restores carbohydrate metabolism, reduces fatty degeneration, and activates bile secretion.

Thiamine coenzyme has an antioxidant effect.

Contraindications

Instructions for use of the drug does not allow its use in case of individual intolerance. Metabolic therapy is not recommended for patients with stable angina.

Postinfarction cardiosclerosis is treated with cardiac drugs, and the thiamine coenzyme, ATP, Riboxin have not stood the test of time. On the background standard treatment the appointment of the drug does not lead to an increase in exercise tolerance.

After the use of coenzyme thiamine, the patient often develops:

• allergic reactions;
• dyspepsia;
• excitation.

Type 2 diabetes causes cardiac autonomic neuropathy. The use of a vitamin substance in some patients leads to a deterioration in the condition, and indicators characterizing the reactivity of the cardiovascular system normalize slowly.

It is not recommended to administer the drug to patients in a state of hepatic coma, if the patient has previously experienced allergic reactions. In liver disease, the drug is prescribed to prevent glycemia and as parenteral nutrition with 5% glucose solution.

Patients with chronic pathology hepatobiliary system and allergies do not need to take the drug, because in the body in the absence intensive care irreversible consequences develop.

How to breed

To prepare a solution administered intramuscularly, the contents of 1 ampoule are dissolved in several milliliters of water for injection. For drip administration, a special solvent is used - a 0.9% solution of sodium chloride. In some cases, a dextrose solution is used.

The standard ampoule contains 2 ml of water for injection. For jet administration, 10-20 ml of solution is sufficient, for intravenous infusion performed by drip, 200-400 ml is used. Powder for the preparation of the solution is supplied complete with ampoules containing sodium acetate. One package includes 3 sets, each consisting of 0.05 g and 2 ml ampoules.

How to use

The drug is administered intramuscularly, sometimes under the skin, or added to droppers. In diabetes, the therapeutic dose is 0.1-1.0 g per day. The amount of the administered substance for adults is from 50 mg to 1 g 1 time per day. Course treatment lasts from 15 to 30 days.

children

Injections of the drug prescribed by the doctor for stimulation defensive forces body in patients with adhesive otitis media, include in complex therapy simultaneously with physiotherapy and mechanotherapy. The drug is administered intramuscularly at a dose of 50-100 mg per day.

For Therapy hemolytic disease newborns use vitamins E, B1, B2, B6, thiamine phosphate ester, which improve the functioning of the biliary tract and metabolic processes. Treatment of liver cirrhosis in children includes the appointment of several courses of vitamin therapy.

To stimulate the body's defenses, the child is given the following drugs:

• Rutin;
• riboflavin;
• folic acid.

For treatment hereditary nephritis in a child, the drug is prescribed intramuscularly. The drug is used for course therapy 2-3 times a year. With the development meningococcal infection thiamine coenzyme is administered intravenously.

Adults

For infusion, 100-150 mg of the drug is used 3 times a day. In acute liver failure, the lyophilizate is administered dropwise in a 5% dextrose solution. Total medicinal substance should not exceed 150 mg / day.

The use of the drug cocarboxylase in peripheral neuritis in elderly patients involves intramuscular administration of the drug at a dose of 100 mg per day for 30 days.

For the treatment of familial spastic paralysis of Shtrumpel, coenzyme tablets are used, which have a general strengthening effect, combining their intake with ATP, Cerebrolysin, Aminalon.

Capsules of phosphoric ester of thiamine, Panangin and Anaprilin tablets are indicated for violation of depolarization processes accompanying ischemic disease hearts. For the treatment of hypovitaminosis in the oral cavity, vitamin ampoules containing 0.05 g of the active substance are used.

Side effects

A vitamin agent prescribed to a patient in the form of injections can cause side effects:

• redness of the skin at the injection site;
• edema;
• pain.

Before using the medicine to treat such a dangerous condition as metabolic acidosis, the doctor finds out if the patient is sick bronchial asthma or atopic dermatitis.

allergies

The patient may develop numerous rashes on the skin:

• nodules;
• bubbles filled with transparent contents.

Often the patient complains of small red spots. With prolonged illness inflammatory process covers large areas of the skin. allergic rashes accompanied by intense itching.

If you refuse injections of the drug, a complete recovery is possible. nervous tension enhances allergy symptoms that occur after the administration of the drug. In children, redness spreads to large areas of the skin.

special instructions

It must be remembered that the dehydrogenase cofactor affects the action of cardiac glycosides. The drug promotes better tolerance of Digoxin, Strophanthin, Korglikon, normalizes energy metabolism in the myocardium. It is unacceptable to combine it with medicines containing paracetamol.

Use during pregnancy and lactation

To prevent toxicosis and metabolic acidosis in the first trimester, a woman is prescribed a dehydrogenase cofactor involved in the formation of nucleic acids, acetylcholine, and nucleotides.

For a pregnant woman, an overdose of a vitamin remedy is harmful.

Metabolic support reduces the risk of preterm birth and low birth weight. The medicine prevents obstetric complications:

• preeclampsia;
• fetal growth retardation;
• premature detachment of the placenta.

Taking medication for diabetes

Metabolic therapy is carried out with diabetic polyneuropathy.

The patient is prescribed for treatment the drug Cocarnit, containing the following substances in 1 ampoule:

• triphosphadenine disodium trihydrate - 10 mg;
• cyanocobalamin - 0.5 mg,
• nicotinamide - 20 mg.

Phosphoric ether of thiamine reduces the content of lactic and pyruvic acid in the body, improves the nutrition of the nervous tissue.

Overdose

For elderly patients, the drug is prescribed at a lower dose. Dropper with medicine for prolonged bed rest often has an adverse therapeutic effect.

In the elderly, severe adverse reactions are manifested in the form mental disorders, cerebral complications, shortness of breath, feelings of lack of air, tachycardia. Sometimes the patient complains of the appearance of symptoms such as:

• fatigue;
• dizziness;
• noise in ears;
• excitation.

It is necessary to take into account the characteristics of the patient's body in order to prevent an overdose of the drug. A metabolic agent in small doses corrects neuropsychiatric disorders.

Interaction with other drugs

The drug enhances the effect of drugs used to treat chronic heart failure. Digoxin in combination with thiamine coenzyme reduces the absorption of the active substance and its metabolites.

Do not prescribe the drug simultaneously with solutions that have an alkaline or neutral reaction. Antidepressants in combination with a vitamin increase their effect, which can easily lead to overdose and the development of unwanted side effects.

With obstetric peritonitis in postpartum period cardiac glycosides are used to normalize hemodynamics. The drug enhances their action, can be administered simultaneously with Trental.

The medicine negatively affects the reception of contraceptives.

The drug has no negative effect on pharmachologic effect drugs such as:

• Kanamycin;
• Glutamic acid;
• Prednisolone;
• Essentiale;
• Lactulose.

They are prescribed for the treatment of hepatic coma. Thiamine diphosphate can be taken with riboflavin, nicotinic acid, pyridoxine hydrochloride, Riboxin, vitamin C. The drug enhances the effect of Korglikon in the treatment of poisoning with tranquilizers.

Manufacturers

The drug is produced by several companies:

• Lelfa S.A. Poland;
• NPO Microgen Russia, Moskhimfarmpreparaty im. N. A. Semashko.

Analogues

Modern medicine offers drugs that are similar in indications and pharmacological action:

• Neurorubin;
• Magne Express;
• Milgamma;
• Tsinsil-T;
• Laetrile B17;
• Demoton;
• Ziman;
• Neuromax;
• Neurobex.

Riboxin contains substances that normalize cellular respiration. The drug has the following effect:

• metabolic;
• antiarrhythmic;
• increases the force of heart contractions

Mexidol, produced in the form of ampoules and tablets, reduces the concentration of lipids in tissues and body fluids. The drug has an antioxidant effect, stabilizes erythrocytes and platelets during hemolysis, reduces the syndrome of endogenous intoxication.

Cocarnit in the treatment of diabetic polyneuropathy

Milgama preparation, instructions. Neuritis, neuralgia, radicular syndrome

Conditions for dispensing from a pharmacy

The drug is sold in all pharmacies. To purchase it, you must show the doctor's prescription to the pharmacist.

Price for Cocarboxylase

Favorable price corresponds high quality. The drug can be purchased for 123 rubles, but the cost of the drug in different pharmacies may vary.

Storage conditions of the drug Cocarboxylase

The medicine saves everything medicinal properties subject to the established rules for storage - temperatures not higher than + 25 ° C.

Best before date

Thanks to special packaging, the drug is stored for 3 years. It must be kept out of the reach of children.