Duphaston during pregnancy and planning. Important questions about the drug. Can you feel sick from duphaston
Confirmed endogenous progesterone deficiency (endometriosis, luteal phase deficiency, recurrent fetal loss or threatened abortion, premenstrual syndrome, menstrual disorders, secondary amenorrhea, dysmenorrhea).
Hormone replacement therapy (surgical castration, including with a preserved uterus; menopausal syndrome - is used when it is necessary to neutralize the proliferative effect of estrogens on the uterine mucosa when using estrogens for HRT).
Pharmachologic effect:
Dydrogesterone, which is the active substance of duphaston, is a progestogen, an analogue of natural progesterone. It has no estrogenic, androgenic, corticoid effect. It does not change thermogenesis, so the presence of ovulation can be determined by monitoring basal body temperature. Does not affect metabolism. side effects associated with the use of synthetic progestins, has not. Effective when used internally. Selectively affects the progestin receptors of the uterine mucosa. Causes normal secretory transformations in the endometrium in case of sufficient estrogen saturation. Does not affect the ovulation of the follicle. It does not have a virilizing and / or masculinizing effect (including on the fetus).
After oral administration, it is rapidly absorbed from gastrointestinal tract. The maximum concentration in the blood after administration is observed after 2 hours. 97% of dydrogesterone binds to blood proteins. Hydroxylated in liver cells. Elimination of biotransformation products occurs in the urine (56-79%). After 72 hours, after a single dose, it is completely excreted from the body. It does not accumulate, there is no increase in the concentration of dydrogesterone in patients with kidney failure.
Duphaston method of administration and dosage:
Destination plans are indicative only. For maximum therapeutic action should be considered Clinical signs diseases and phases of the natural menstrual cycle. The daily dosage is divided into several doses, preferably at regular intervals.
With endometriosis, 10 mg of dydrogesterone is used 2-3 r / s (without interruptions or from the 5th to the 25th day of the menstrual cycle).
With infertility of progesterone genesis 20 mg / day (in 2 divided doses) from the 11th to the 25th day of the MC inclusive. The course of treatment is 3-6 months. If the patient becomes pregnant, treatment should be continued at the dose recommended for recurrent pregnancy loss. The dose of dydrogesterone allows you to adjust the cytological examination of the vaginal epithelium (colpocytology).
Habitual pregnancy loss and threatened abortion - used only if there is evidence of endogenous progesterone deficiency.
With threatened abortion, 40 mg of dydrogesterone is used as a starting dose 1 time, then 10 mg every 8 hours for 1 week. After that, the dosage is gradually reduced. However, with the resumption of signs of threatened abortion, it is possible to increase the dose again. Can be used up to 12-20 weeks of pregnancy.
With habitual miscarriage, therapy is started when planning pregnancy: 10 mg 2 r / s from the 11th to the 25th day of the menstrual cycle. If conception has occurred, therapy is carried out at the same dose constantly, from the 20th week of pregnancy, the dose is gradually reduced. Clarification of the need to increase or decrease the dosage of dydrogesterone is possible after a colpocytological study.
With premenstrual syndrome (PMS) - 10 mg from the 11th to the 25th day of the menstrual cycle. The duration of therapy is 3-6 months.
With dysmenorrhea - 20 mg / s in 2 doses from the 5th to the 25th day of the menstrual cycle, for 3-6 months.
With irregular menstrual cycle due to a short luteal phase, 20 mg / day is used, in 2 divided doses from the 11th to the 25th day of the cycle.
In the treatment of amenorrhea, it is used in combination with estrogens. Apply 10 mg of dydrogesterone 2 times every day from the 11th to the 25th day of the menstrual cycle while taking 0.05 ethinylestradiol from the 1st to the 25th day of the cycle. The duration of treatment is 3 or more menstrual cycles.
For dysfunctional bleeding, it is used at a dose of 10 mg 2 times a day for 5-7 days in combination with ethinyl estradiol 0.05 mg (this regimen stops bleeding). For prevention, 10 mg of dydrogesterone 2 r / s is used from the 11th to the 25th day of the menstrual cycle, combined with 0.05 ethinylestradiol 1 r / s.
As HRT is used only in combination with estrogens.
With continuous therapy, 10 mg is used for 14 days each menstrual cycle. With cyclic use - only in the last 12-14 days of estrogens, 10 mg 1 r / s. If necessary (insufficient secretory transformations of the endometrium, confirmed by ultrasonography or histologically), the dose is increased to 20 mg / day.
Duphaston contraindications:
Contraindicated in certain liver diseases (Rotor and Dubin-Johnson syndromes), also in case of individual intolerance to dydrogesterone or other components of the product.
Duphaston side effects:
Rarely - breakthrough bleeding. In this case, the dose of dydrogesterone must be increased. There may also be individual high susceptibility to the product.
Pregnancy:
Not contraindicated in pregnancy. If it is necessary to take the product during lactation, feeding must be canceled (penetrates breast milk).
Overdose:
There are no reports of cases of overdose of dydrogesterone. In case of overdose, symptomatic therapy and gastric lavage should be used.
Use with other medicinal products:
There have been no cases of incompatibility of dydrogesterone with other medicinal products. Phenobarbital and other inducers of hepatocyte microsomal enzymes can increase the biotransformation of dydrogesterone in the liver, thereby reducing its clinical efficacy.
Release form:
Tablets for oral use.
Storage conditions:
Store at a temperature of 0-30 ° C in a place protected from light and children's access. Do not consume later than the period expiration date indicated on the package. The storage period under the conditions is 5 years. It is dispensed from pharmacies upon presentation of a prescription.
Synonyms:
Dydrogesterone, dufaston
Duphaston composition:
Active ingredient: dydrogesterone 10 mg in 1 tablet.
Auxiliary components: lactose monohydrate, corn starch, methyl-hydroxy-propyl-cellulose, white dye (Opadry Y-1-1000), magnesium stearate, anhydrous colloidal silicon dioxide.
Additionally:
In combination therapy with estrogens, it should be used cautiously in patients with renal insufficiency, heart and vascular diseases, epilepsy, diabetes, migraine.
Dydrogesterone does not change the speed of psycho-physical reactions when used - you can drive vehicles and complex mechanisms.
If the patient had a history of liver dysfunction (jaundice in pregnancy, severe pruritus during pregnancy) - appoint with caution.
Prior to appointment as substitute hormone therapy carry out necessary research. In the future, regularly scheduled mammography examination.
Attention!
Before using the medication "Duphaston" you need to consult a doctor.
The instructions are provided solely for familiarization with " Duphaston».
Duphaston is a drug widely used in gynecology. Main active substance is dydrogesterone (synthetic progesterone), which has a positive effect on reproductive function and pregnancy carrying capacity.
Common side effects
Duphaston is well tolerated and has virtually no side effects. Its intake must be agreed with the doctor, as the dosage and regimen are selected individually. Before this, the patient undergoes an examination, takes tests.
Side effects may be associated with improper intake.
The most common drug side effects are:
- Dizziness
- Nausea
- Headache
- Bloating.
They may appear in combination.
Other side effects
Among other side effects, phenomena characteristic of female body with hormonal changes. Among them are such as:
- Skin deterioration and acne
- Breast tenderness and pressure pain
- Change in the strength of sexual desire (may increase or disappear)
- General malaise
- Allergic reaction
- Painful sensations in the abdomen
- The ovaries may hurt.
Allergies usually show up skin rashes, urticaria and itching. In addition, the head may disturb.
The most rare manifestations are:
- Bleeding between periods
- Anemia
- Violations in the liver.
These symptoms indicate the need for immediate discontinuation of the drug.
Weight changes
Side effects from taking hormonal drugs can be expressed in a change in body weight.
The tool does not affect the metabolism and the weight should not increase from its use.
But such consequences cannot be ruled out. Natural weight gain may occur in pregnant women who are prescribed a hormone to maintain pregnancy. In this case, the increasing body weight does not depend on the drug in any way, but is associated with the growth of the fetus.
If Duphaston eliminates other problems reproductive system, then the increasing weight may be due to malnutrition. The drug may increase appetite. You should not fight it by increasing the consumption of high-calorie foods.
Toxicosis and drug reaction
According to women, nausea from Duphaston is observed more often than other symptoms of intolerance. The drug is often given to patients who are unable to conceive or whose natural progesterone levels are so low that a miscarriage is likely. When nausea occurs, it is not always clear what it can be caused by. It may be a symptom of pregnancy or a reaction to a drug.
The medication is also prescribed for other women's problems. For example, to treat endometriosis, relieve manifestations of PMS, at menopause. These conditions affect well-being and can manifest themselves in the same way as a side effect from Duphaston.
If a severe nausea accompanied by vomiting, general feeling unwell, you need to see a doctor. He will tell you whether Duphaston can make you sick in a particular case. With such a reaction, the dosage of the drug is usually changed or another drug is selected.
If a woman is taking other medications, they should be checked for compatibility. In some cases, Duphaston is sick if its components are not combined with substances in other medicines.
Headache
Sometimes women complain about their heads. She may be spinning or disturbing pain syndrome. This may be a reaction to a change in the concentration of the hormone or existing health problems. Some women note that it hurts for a short time after taking the pills. With a persistent migraine, supplemented by other symptoms of intolerance to the medication, you should consult a doctor.
If before the start of therapy the head never hurt, then this may indicate an individual intolerance to the medication.
To reduce the likelihood of side effects of the drug. In order not to feel sick, not to disturb the gastrointestinal tract, not to suffer from migraines and other pains, it is recommended to reconsider your diet in favor of diet food. In addition, do not smoke, use alcoholic drinks and coffee.
Full instructions with analogues and reviews are available at the link:
The abstract indicates that the active substance is included in the composition of Duphaston , as well as excipients: corn starch, lactose monohydrate, methylhydroxypropyl cellulose, dye, magnesium stearate, anhydrous colloidal silicon dioxide.
Release form
The product is produced in the form of tablets 10 mg No. 10 biconvex, round shape. Tablets white color have bevelled edges, they are covered with a shell. On one side of the tablet there is an engraving " S» above the sign « 6 ", on the other hand - the risk and the sign" 155 on both sides. In total, the blister contains 20 tablets, one blister is put into a cardboard box.
pharmachologic effect
The active component of the drug dydrogesterone is an analogue of natural . Dufaston is a hormonal drug.
Under the influence of this medicine, there is no violation of thermogenesis in the body of a woman, therefore it can be measured basal body temperature to determine ovulation. The tool has no effect on metabolic processes in the body, on liver function. Dydrogesterone in properties and structure is very similar to natural progesterone. However, the drug does not provoke the manifestation of those side effects that occur when taking a number of synthetic progesterones. Wikipedia indicates that this remedy does not have an androgenic, estrogenic, anabolic, thermogenic, corticoid effect. As a component of hormone replacement therapy for LS provides a positive effect on the lipid profile women. But if estrogens have a negative effect on the blood coagulation process, then dydrogesterone does not affect coagulation.
When taken orally, there is a selective effect of dydrogesterone on which contributes to the prevention of a high risk of manifestation endometrium or carcinogenesis, provoked by increased production of estrogens. The medicine does not have a contraceptive effect. During treatment, the drug does not affect ovulation. Menstruation while taking the remedy also continues according to the usual cycle. A woman can get pregnant with dydrogesterone and keep in the process of treatment with the drug, since in the process of treatment there is no negative effect on the fetus. There is a selective effect on the progestin receptors of the uterine mucosa. It does not affect the ovulation of the follicle. There is no masculinizing and virilizing effect.
Pharmacokinetics and pharmacodynamics
After oral administration, dydrogesterone is rapidly absorbed from the gastrointestinal tract, after 2 hours the highest concentration of the active component in the blood is noted. The degree of binding to blood proteins is 97%. 56-79% is excreted from the body by the kidneys, a day after ingestion, about 85% is excreted from the body, the entire excretion process is completely completed after 72 hours. are present in the urine mainly as glucuronic acid conjugates .
There are no data on changes in the pharmacokinetics and pharmacodynamics of the active ingredient in people who suffer from kidney disease. Does not accumulate.
Indications for use
Why Dufaston tablets are prescribed depends on the diagnosis and treatment regimen, which is determined by the doctor.
Currently, the following indications for the use of the drug are determined:
- Lack of progesterone in the body (with infertility associated with luteal phase deficiency, with a threat or habitual loss of the fetus, with , violations of the monthly cycle, amenorrhea of secondary genesis).
- As part of hormone replacement therapy (during menopause, it is used to neutralize the proliferative effect of estrogens on the uterine mucosa when using estrogen; during surgical castration).
Thus, tablets are prescribed for dysfunctional uterine bleeding, with , with cyst corpus luteum, with endometritis, with .
From what the medicine is prescribed yet, when it is prescribed, and what the dosage should be, you should ask your doctor.
Contraindications
There are contraindications for taking the drug Duphaston.
First of all, do not take pills with high sensitivity to dydrogesterone or to other components of the medicine, as this can harm the woman's body.
Caution tablets are prescribed to women who have suffered from manifestations during pregnancy before.
There is no data on the negative impact of dydrogesterone on people who suffer in a chronic form.
Side effects of duphaston
During the reception, some side effects of Duphaston may be noted:
- the immune system: hypersensitivity (very rare);
- hematopoietic system: hemolytic anemia(isolated cases);
- nervous system: , ;
- hepatobiliary system: minor violations of liver function, in which weakness, jaundice, abdominal pain may occur;
- reproductive system : breakthrough bleeding when taken (rare), prevented by increasing the dosage of the drug; may increase the sensitivity of the mammary glands;
- subcutaneous tissue, skin: itching, (rare), (very rarely);
- general disorders: peripheral (very rare).
If any of these symptoms appear, you should tell your doctor that such a side effect is taking place.
Instructions for use Duphaston (Method and dosage)
The drug is prescribed according to an individual scheme, both when planning pregnancy, and when gynecological diseases. How to take, before meals or after, it does not matter.
Duphaston tablets, instructions for use
The indicated reception patterns are indicative only. To prescribe a therapy regimen, determine how long you can take the pills, the doctor must take into account the symptoms of the disease, the phases of the monthly cycle. daily dose medicines should be divided into 2-3 doses, you need to drink tablets at regular intervals.
Duphaston with endometriosis appoint a dose of 10 mg of dydrogesterone 2 or 3 times a day. How to take Duphaston for endometriosis depends on the doctor's prescription. You need to take the remedy from the 5th to the 25th day of the cycle, or do it without a break. It should be borne in mind that only the attending physician can prescribe Duphaston for endometriosis. Reviews of doctors on the Internet or any medical forum with information about treatment should be taken only as information for review.
Duphaston for conception infertilityprogesterone genesis appoint from 11 to 25 days of the monthly cycle. How to take Duphaston for conception, you must definitely find out from a specialist. As a rule, the reception lasts for 3-6 months. How to take Duphaston to get pregnant, how much to drink to get pregnant depends on the woman's diagnosis, individual characteristics her body.
If there is a delay after taking the pills and others appear while taking the drug, treatment should continue, while the dose should be equal to that prescribed for habitual pregnancy loss.
If a woman has risk of miscarriage or habitual pregnancy loss , it is advisable to use the drug only if there is clear evidence of endogenous progesterone deficiency. Women with threatened abortion are shown single dose dydrogesterone 40 mg, then during the week you need to take 10 mg every 8 hours. Further, the dose is gradually reduced. But if the threat of abortion again arises, the dose is increased. The application can be practiced up to the 20th week of pregnancy. But more precisely, until which week to take pills during pregnancy, the doctor will advise individually.
How to take the threat of miscarriage early dates , the doctor determines individually. As a rule, with habitual miscarriage at the stage of pregnancy planning, Duphaston is taken from the 11th to the 25th day of the cycle, provided that conception has occurred, the woman continues to receive the same dose. Further, after the 20th week of pregnancy, the dose should be gradually reduced.
Women suffering from PMS are prescribed tablets from 11 to 25 days of 10 mg, the treatment lasts from 3 to 6 months.
Duphaston at delayed menstruation , at irregular cycle and other violations of menstruation are prescribed from 11 to 25 cycles, 2 times a day, 20 mg. How to induce menstruation with Duphaston depends on the diagnosis of the woman. The doctor prescribes the drug for an irregular cycle, determines how to take Duphaston to induce menstruation, how much to drink to induce menstruation. Whether it is possible to induce menstruation with amenorrhea depends on the correctness of the treatment. As a rule, the reception of Duphaston in this case is combined with the reception estrogen . Such treatment should be practiced for at least three monthly cycles.
When dysfunctional bleeding prescribe the drug at 10 mg twice a day, for 5-7 days, combining the intake with 0.05 mg . In order to prevent the development of bleeding, tablets are prescribed at a dose of 10 mg in the period from 11 to 25 days of menstruation. Reception is combined with 0.05 mg of ethinyl estradiol (1 time per day).
If necessary hormone replacement therapy practiced in combination with estrogens. Continuous treatment involves taking 10 mg of the drug for 14 days during each monthly cycle. If necessary, the dose may be increased to 20 mg per day.
How to take Dufaston endometrial hyperplasia , depends on what other drugs the doctor prescribes for treatment. As a rule, the treatment of endometrial hyperplasia involves taking the drug at a dose of 10 mg from the 16th to the 25th day of the cycle.
How to take Dufaston ovarian cyst , also depends on the appointment of a specialist. With an ovarian cyst, treatment should continue for at least 3 months.
Treatment follicular cyst ovary provides for the appointment of 10 mg of the drug 2 times a day. A similar dose per day is prescribed if treatment is underway. ovarian dysfunction and also if diagnosed multifollicular ovaries .
If a woman missed a Duphaston tablet, then an additional dose should not be taken. You need to continue taking the next pill. For convenience, you can count how many tablets are left in the Duphaston package and control the regularity of taking.
With any diagnosis, Duphaston should not start drinking without a doctor's prescription.
Overdose
There is no information on drug overdose. If a high dose has been taken accidentally and the patient has discomfort or nausea from the tablets, gastric lavage should be carried out and symptomatic therapy should be carried out.
Interaction
With the simultaneous use of microsomal liver inducers ( , Phenobarbital) may accelerate dydrogesterone and reduce the effect.
There are no data on incompatibility with other drugs.
Duphaston and can be administered in parallel, most often when planning a pregnancy. Proginova is an estrogen drug.
Duphaston and are prescribed in the complex for the treatment of infertility. Clostilbegit is a non-steroidal antiestrogen that stimulates ovulation.
Borovaya uterus and Duphaston - the compatibility of these drugs is controversial. There is evidence that the phytopreparation upland uterus in combination with Duphaston can cause bleeding.
Terms of sale
In pharmacies, they are sold by prescription, patients write out a prescription in Latin.
Storage conditions
The manufacturer provides that the tablets should be stored at a temperature not exceeding 30 ° C, in a dry place.
Best before date
5 years. After this period, it should not be used.
special instructions
If Duphaston is used in combination with estrogens, care must be taken in patients suffering from vascular, heart, kidney diseases, , , migraine. It is also carefully prescribed for liver diseases.
If a woman is prescribed a drug for the purpose of hormone replacement therapy, a series of studies should be carried out before starting, and later, regular mammographic examinations should be carried out. It is important to consider all contraindications. The doctor must clearly study the patient's history. In the process of HRT, the tolerability of such treatment should be monitored with a certain frequency. There is a possibility of breakthrough bleeding in the first months of therapy. If such bleeding also occurs after a course of treatment, a woman needs to have an endometrial biopsy to rule out malignant processes.
Duphaston should not be taken by those who suffer from lactase deficiency, galactose deficiency or malabsorption syndrome.
Does not affect the ability to drive a car or work with precise mechanisms.
If discharge occurs regularly when taking pills, you should tell your doctor about it.
Since Duphaston is a synthetic progesterone , it can replace natural hormone progesterone, for which Duphaston is prescribed to pregnant women, as well as to women during pregnancy planning. How to drink Duphaston to get pregnant is determined by the attending physician. When asked whether this drug suppresses ovulation, experts unambiguously answer in the negative. How this medicine affects ovulation depends on the frequency and duration of its administration.
Often women are interested in whether the drug can cause delay in menstruation , or how to drink to induce menstruation. It should be understood that the regulation of menstruation is provided by the production of estrogen and progesterone in the body. Often a woman notes that she has not started her period if there is a lack of progesterone in the body. If the ovaries do not produce enough progesterone for any reason, a course of Duphaston is prescribed. If menstruation did not come after taking Duphaston, you should do it. Provided that there are no periods after discontinuation of the drug, and the woman is not pregnant, she should definitely consult a doctor. The reason for meager periods after the drug may be a lack of estrogen, late ovulation, changes in the uterus.
It should be borne in mind that, while practicing Duphaston to call menstruation "for convenience", without prior doctor's prescription, a woman, although she causes menstruation, runs the risk of disrupting the functions of the hormonal system. As a result, after uncontrolled treatment, a woman sometimes complains that she has heavy periods after taking the pills or that her periods are long.
Therefore, the answer to the question of whether Duphaston can be taken without a doctor's prescription is unequivocal: this should not be done.
Another question of interest to women: do they get better from Duphaston? Namely, do they get fat from it with prolonged use? Because active substance the drug is synthetic progesterone, then the question of whether they get fat from it, experts answer in the negative.
Duphaston's analogs
Coincidence in the ATX code of the 4th level:
Any substitute for Duphaston must be approved by the attending physician. What can replace this drug depends on the diagnosis of the patient and the individual course of the disease. The analogue in composition is the drug , other drugs with similar action are the means , progesterone in ampoules , etc. The price of Duphaston analogues may be slightly lower.
Utrozhestan or Duphaston - which is better?
Comparison of these drugs indicates that both drugs have similar indications for use. But it is not difficult to determine what the difference is: Utrozhestan, unlike Duphaston, contains natural progesterone from plant raw materials. Which is better - Duphaston or Utrozhestan - during pregnancy, can only be determined individually. But Utrozhestan also has a sedative effect on the body. Sometimes both drugs are prescribed at the same time during pregnancy.
Which is better: Duphaston or Norkolut?
Norkolut is also used in gynecology. However, it has a different active ingredient - norethisterone. It's over cheap drug, but it is possible to prefer this or that drug only after consulting a doctor.
Prajisan or Duphaston - which is better?
Prajisan is a hormonal drug, an analogue of Duphaston. It has similar indications, but its cost is lower. But still, doctors do not recommend making a decision on replacing funds on their own.
For kids
Children are not assigned. It can be practiced to prescribe the drug to adolescent girls with violations of the monthly cycle. How to take these pills in violation of the cycle in girls, the doctor individually determines. After consultation, he determines whether it is possible to drink during menstruation, and whether it is advisable to do so.
Duphaston and alcohol
Since the drug often has to be drunk over a long period, many women are interested in whether it is possible to drink alcohol while taking Duphaston. There is no information about this in the instructions for the drug. At the same time, many reviews indicate that alcohol was consumed in small quantities. However, doctors warn that combining alcohol and hormonal drugs can adversely affect hormonal background, on the functions of the liver and provoke other negative phenomena. In addition, the effectiveness of the product when combined with alcohol is significantly reduced. For those who become pregnant on Duphaston, alcohol is strictly contraindicated.
Duphaston during pregnancy and lactation
The instruction indicates that the drug can be drunk during pregnancy. Taking pills during pregnancy is possible in the early stages in order to prevent miscarriage. Therefore, Duphaston during pregnancy in the early stages is prescribed to women who have previously suffered from habitual abortion, or who have had a miscarriage. But, as a rule, the doctor recommends that such patients take Duphaston when planning pregnancy. Is it possible to drink the drug, how much to take and how to take Duphaston when planning a pregnancy, the doctor determines after the woman is tested for progesterone. In the process of discussing the drug Duphaston during pregnancy, the doctors' reviews indicate that this drug should be prescribed only after a comprehensive and thorough examination of the patient.
As a rule, during the planning of pregnancy, the drug is taken for 3-6 months. You need to drink the remedy from 11 to 25 days. But this scheme is relevant only for women who have monthly cycle is 28 days. How much to drink drugs with a different cycle duration, the doctor will tell.
It is important to know about how to cancel this medicine during pregnancy. Provided that the pregnancy occurred while taking the pills, Duphaston should be taken further. During the period of gestation, the dosage is 20 mg of the drug per day (two doses). It should also be taken into account how to cancel Duphaston during pregnancy correctly. Be sure to consult a doctor about how to reduce the dose and until what week they drink pills. The withdrawal regimen during pregnancy provides for taking the drug until the 20th week of pregnancy, but sometimes how long to take the medicine depends on the individual health condition future mother. Some women are advised to cancel as early as 16 weeks. But in any case, only a gynecologist should recommend in detail how to cancel Duphaston during pregnancy. You can not be guided by the advice that other women write on forums or in reviews about the remedy. After taking and after discontinuation of the drug, it is important to regularly monitor the condition of the woman. During pregnancy, in some cases, Duphaston and Proginova are prescribed at the same time.
Often, pregnant women are interested in how Duphaston affects the body as a whole, in particular, whether they recover from it. It should be noted that weight gain during pregnancy is a physiological process, it is not associated with taking pills.
Some of them are designed to protect against unexpected pregnancy, while others, on the contrary, help to conceive a baby. This article will focus on the drug "Dufaston". How to take it correctly? How to store and in what cases should you refuse such a drug? We will answer all your questions.
General description of the medicinal product
Tablets "Dufaston" have a white matte color. They are quite small size. covers medicine thin shell, which consists of a film that dissolves in the stomach.
Tablets "Dufaston" are divided into two parts by a special strip. One of them has the inscription "115". The drug is an artificial analogue of the sex hormone progesterone.
Deciphering pharmacological properties
The action of "Duphaston" occurs already approximately one hour after administration. In the body at this moment, an increase in the level of progesterone is observed. It should be noted that the drug does not contain additional female and male hormones: estrogens and androgens.
The drug is excreted along with urine. The absence of traces of the drug can be observed already three days after last appointment tablets. The amount of the dose received does not depend on the period of excretion of this substance from the body.
The half-life of the drug begins to be observed after about ten hours, which is why, in order to maintain a constant concentration in the human body, a second dose of the drug is prescribed at regular intervals.
The composition of the drug
One package of the drug is made of thick cardboard. Inside you can find a plate with pills. Usually they are produced in 20 pieces in one box.
One tablet contains dydrogesterone, which is the active ingredient. Its amount is 10 milligrams per tablet.
Also as additional excipients the following can be found in the tablet: lactose monohydrate, corn starch, methyloxypropyl cellulose, magnesium stearate and anhydrous colloidal silicon oxide.
Tablets "Dufaston": how to take and how much
As with any other drug, this drug there are indications for use. In what cases is this medicine prescribed, and how to drink "Dufaston"?
Indications for appointment
Quite often, this drug is prescribed to the fairer sex as hormone therapy. In this case, the goal of the doctor is to stop the effect of estrogen hormones on the female endometrium. Quite often, this method is resorted to during menopause. This technique helps reduce the risk of cancer.
Treatment with "Dufaston" is also prescribed to women who have various hormonal diseases such as endometriosis. In this case, the main goal is also to reduce negative impact estrogen and endometrial growth retardation. Also, the drug "Dufaston" has the ability to reduce the production of androgens, which contribute to the development of endometriosis.
In the case when there is a lack of progesterone in the body of a woman, this drug can also be prescribed. With a pronounced premenstrual syndrome, the use of the drug "Dufaston" is indicated.
Women with disabilities menstrual bleeding, their irregularity and frequent parishes prescribe this drug.
During pregnancy, quite often women have to take this drug. In this case, the main goal is to maintain the work of the corpus luteum and replenish the missing level of progesterone.
With a long absence of pregnancy, the drug "Dufaston" is prescribed. In this case, it supports the second phase of the cycle and does not allow menstruation to begin ahead of time.
Dosage of the drug
If you are prescribed the drug "Dufaston", how much to drink it and for how long, the doctor decides on an individual basis. Everything will depend on the purpose for which the treatment was prescribed. Consider each individual case of taking the drug "Dufaston". How to take it in this or that case?
To begin with, it is worth noting that one tablet is usually taken at one time. It must be washed down with plenty of water. The intake of the drug does not depend on food consumption at all. Like all hormones, this drug must be taken exactly at the same time. Try not to skip the next tablet, as otherwise the effect of the substance will be reduced, and healing effect will not reach its maximum.
hormone therapy
In most cases, to achieve an effective result, the drug is prescribed in conjunction with estrogens. First, you use estrogen-containing drugs, until about the middle of the cycle. After that, it's time to take the drug "Dufaston". Usually one tablet is prescribed per day. The course of admission is from 12 to 14 days.
With hormonal diseases
In the case of treatment of endometriosis or with an irregular cycle, the patient is prescribed the drug from the 5th to the 25th day of the cycle. The medicine must be taken one tablet twice a day. In this case, it is necessary to divide the day into two equal parts and take the medicine at regular intervals. Only in this way can you achieve the maximum concentration of a substance in the body.
With bleeding
In this case, the drug is prescribed for one week. The patient should take one tablet twice a day at regular intervals.
Prolonged absence of menstruation
If the reason for the absence of menstruation is not pregnancy, then Duphaston tablets are prescribed from the 11th to the 25th day of the female cycle. You need to take one tablet twice a day.
PMS and irregular periods
In this case, the medication is started on the 11th day and continued until the 25th day. It is necessary to drink the medicine twice a day, one capsule.
During pregnancy
During the period of bearing a child, this medicine is prescribed in case of a lack of progesterone. If a woman has bleeding, then she needs to take 4 tablets once. After that, it is recommended to take the medicine one capsule every 8 hours. When the symptoms disappear, you can cancel hormonal agent however, care must be taken to ensure that the symptoms do not recur.
If a pregnant woman has a lack of progesterone, then the drug is prescribed to be taken twice a day, one tablet. In this case, the withdrawal of the drug can be carried out only after the complete formation of the placenta, at about 20 weeks.
With infertility
In this case, the medication is prescribed immediately after ovulation. On average, from 14 to 25 days of the cycle. However, when choosing a treatment, it is necessary to take into account the individual female cycle, since the drug "Dufaston" can simply suppress the release of the egg from the ovary.
Contraindications
Like any other medicinal product, the drug "Dufaston" also has side effects. That is why, in order to avoid complications, it is necessary to take into account contraindications to the use of this medication.
Women who have progesterone-dependent tumor processes should not be taken. With endometrial hyperplasia during combination with treatment with etrogen-containing drugs. Bleeding from the genital tract for an unknown reason. Childhood is also a contraindication to the use of the drug.
Tablets "Dufaston": side effects
Quite frequent side effects when taking this drug are severe headaches and migraines. Nausea and dizziness may also occur.
Rarer events include disease state breast, allergic reaction in the form of a rash or itching. It is also possible to develop liver disease.
Very rarely, the following reactions may occur: allergic edema or anemia.
Also, while taking the drug, a depressive state, breast cancer or their increase, thromboembolism, different kinds tumor processes, problems with the heart and blood vessels.
In some cases, the drug "Dufaston" side effects has the following. At various diseases liver and kidneys, there is a deterioration in the patient's condition. Also, with diseases of the veins, their expansion, swelling of the limbs and heaviness in the legs can be provoked.
It is worth saying that if you are taking Duphaston tablets, side effects have arisen, and the condition has worsened, you need to replace the drug with another analogue or completely cancel progesterone.
Storage of the drug
It is necessary to place the drug in a dark place. Keep in mind that the temperature should not be higher than 30 degrees. Also, restrict children's access to the storage area.
After five years from the date of production, it is necessary to abandon the use of such a drug.
Price category
Depending on the region in which the drug "Dufaston" is purchased, the price may differ slightly. On average, the cost of this hormonal medication is in the range from 500 to 1000 rubles. It is also worth noting that in different pharmacy chains, the medicine may have a different cost.
Remember that the drug "Dufaston", the price of which is below five hundred rubles, is most likely a fake. Do not buy such drugs.
By group membership, Duphaston belongs to gestagens, and its active component is dydrogesterone, which, in turn, is quite close in chemical properties and in molecular structure to the natural type of progesterone. It does not have side effects, and is not endowed with anabolic, androgenic, glucocorticoid, estrogenic and thermogenic activity. Simply put, Duphaston is an element of a replacement hormonal treatment, while dydrogesterone does not affect coagulation parameters. Does not adversely affect carbohydrate metabolism and liver function.
When treated with this drug, the therapeutic effect occurs without a violation of menstrual function or suppression of ovulation, that is, it does not harm the course of pregnancy during the treatment period.
Duphaston is efficiently absorbed from the gastrointestinal tract, and a couple of hours after application it reaches its maximum concentration. Metabolism occurs in the liver and is excreted in the urine by the kidneys.
The drug is produced in the form of round white tablets.
A complete analogue of Duphaston is Utrozhestan.
Indications and contraindications for the use of Duphaston
Duphaston is widely used in the treatment of endometriosis, infertility, as well as premenstrual tension syndrome and unstable menstrual cycle.
In addition, Dufaston is used in the diagnosis of dysfunctional uterine bleeding and secondary amenorrhea. It is a productive replacement therapy for hormonal failure in women with menopausal disorders with an intact uterus.
Certain contraindications, which are indicated in the annotation of Duphaston, stipulate that the drug is forbidden to be used when hypersensitivity sick female body to the components of the drug.
Side effects and overdose of Duphaston
From the reproductive system: soreness of the mammary glands, periodic bleeding.
From the side of the central nervous system: migraine and general weakness.
On the part of the digestive system: pain in the abdomen or signs of dyspepsia.
From the hemopoietic system: hemolytic anemia.
Allergic reactions: skin rash, hives a, itching, swelling.
Cases of overdose with Duphaston are not presented, but if the recommended doses are overestimated, symptomatic therapy is necessary after immediate gastric lavage. There is no specific antidote.
Instructions for use Duphaston
The drug is intended for internal use, and the daily doses of Duphaston depend on the nature of the pathology present. Before use, carefully read the instructions:
When diagnosing endometriosis, 10 mg is indicated up to three times a day from the 5th to the 25th day of the cycle, and when diagnosing infertility, 10 mg per day, starting from the 14th to the 25th day of the cycle. The therapy is carried out for a number of menstrual cycles without interruption, and when pregnancy occurs, it should also not be stopped.
With the threat of a miscarriage, you should take 40 mg of Duphaston at a time, and after that - 10 mg every eight hours until the anxiety symptoms disappear.
In premenstrual syndrome and unstable menstrual cycle, take 10 mg twice a day from the 11th to the 25th day of the cycle, and to stop uterine bleeding- 10 mg twice a day for a week.
Features of the use of Duphaston
The drug is approved for use during pregnancy and lactation.
Its reception does not affect the ability to drive vehicles, therefore, during the period of treatment, driving a car and engaging in increased concentration of attention are allowed.
Do not take Duphaston tablets in patients with malabsorption syndrome, lactase deficiency, hereditary intolerance galactose.
At drug interaction it is important to remember that phenobarbital and rifampicin significantly accelerate the process of dydrogesterone metabolism and reduce the effectiveness of the drug itself. No other restrictions are specified.
Reviews about Duphaston, price
Women's problems are a common occurrence in modern gynecology, so there are a lot of reviews about the drug Duphaston. Most of the women who have tried it on themselves, were quite satisfied with the results. Here are a couple of examples.
Maria, 24 years old: " The local gynecologist suggested that I drink Duphaston in case of cycle disorders. I listened to the advice and did not regret it. No side effects, but the result is obvious».
Sveta, 22 years old: " I took Duphaston in the ninth week of pregnancy, because the doctor said that there was a serious threat of miscarriage. As a result, the state stabilized, and the danger passed».
Price for Duphaston tablets 20 pcs. - 495 rubles.
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- Dufaston is medical preparation, which is rather intended for women with a lack of progesterone in the body. It is very effective when prescribed by a specialist, while it has a wide range testimony. general description Duphaston By group affiliation, Dufaston belongs to gestagens, and its active component is dydrogesterone, which, in turn, is quite close in chemical properties and [...]