Bromhexine Berlin Chemi for children at 4 months. A cough remedy with a mucolytic effect - Bromhexine Berlin Chemie syrup: instructions for use for children of different ages. Storage period and conditions

Coughing is a reflex response of the body to irritation. respiratory tract, common reason occurrence – infectious diseases. In order for the cough to go away faster, it is necessary to get rid of phlegm, the cause of numerous complications.

Bromhexine Berlin-Chemie (syrup) for children is used as an effective expectorant. Instructions for use will help you use the product correctly and expectorate secretions productively.

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Composition and pharmacological action

Highly effective application is achieved by the influence of the main component - bromhexine hydrochloride. The instructions indicate that 1 spoon for taking the medicine for children contains 5 ml of syrup (0.04 g of bromhexine). The medication also includes other additional ingredients, including apricot flavor.

Pharmacodynamics

How to use

Bromhexine 4 Berlin-Chemie syrup for children is prescribed for internal use. The duration of therapy according to the instructions for use is 4 days - 1 month.

Important! Do not use the product for more than 5 days without consulting a doctor.

Dosage

The drug is used in pediatrics and, according to the instructions for use, is characterized by high safety and the absence of restrictions. Taking the drug for up to 2 years must be agreed with your doctor.

Newborns and children from 1–2 years old are prescribed ½ tsp. in three steps.
From 2 to 6 years. Drink 5 ml (dosed spoon), three times a day.
Ages 6–14. The recommended dosage is 2 scoops three times a day.
Adults over 50 kg and teenagers over 14 years of age are prescribed 3–4 scoops in 3 divided doses.

The medicine should be taken with caution in patients with impaired renal function or serious liver disease. With such diagnoses, the amount of medication according to the instructions for use is reduced, the interval increases.

An overdose of the drug is manifested by gastric disorders. Providing assistance according to the instructions consists of inducing vomiting and drinking plenty of fluid. It is advisable to rinse the stomach if 2 hours have not passed after exceeding the dosage. The withdrawal period is slow.

Important Notes

The instructions for the Berlin-Chemie drug suggest the following instructions:

Taking syrup is accompanied by drinking a significant amount of water. Expectoration improves.

The use of syrup for children must be combined with drainage massage, which facilitates the removal of sputum from the bronchi.

Bromhexine Berlin-Chemie for children with ulcers and stomach bleeding is taken under the strict supervision of a doctor.

If bronchial motility is impaired, or if there is excessive volume of sputum, take the drug with caution to prevent retention of secretion in the respiratory organs.

Pregnant women should consult a doctor before prescribing the drug to take into account the peculiarities of the course of pregnancy and the balance of benefit and risk. On initial stage the use of the medicine is not recommended.

Restrictions on prescribing the medication according to the instructions for use include hypersensitivity, acute ulcers, and breastfeeding.

Review Reviews

Before use medical product Bromhexine Berlin-Chemie syrup for children, reviews help to present a real picture of the action of the medicine.

Based on the experience of using Bromhexine Berlin-Chemie, the conclusion is that the syrup really helps in 100% of cases.

Patients cite the following advantages:

rapid transition of cough from dry to wet;
excellent expectorant;
effective elimination of cough;
affordable price.

Some patients noted a slightly bitter taste that they wanted to wash down. There are negative reviews associated with misuse drug, failure to follow the instructions for use and self-diagnosis.

Analogs

Similar Berlin-Chemie syrups for children represent medications with the most identical composition according to the instructions.

The most famous substitutes:

Bromhexine Nycomed, manufactured by Takeda Pharma A/S Denmark.
, manufacturer: Pharmstandard.
Bromhexine, manufacturer: Grindeks, JSC Latvia.
, manufacturer: JSC Chemical and Pharmaceutical Plant AKRIKHIN Russia.
Bronchostop, production: SLAVYANSKAYA PHARMACY, LLC Russia.

Syrups are used to treat diseases of the respiratory system of various etiologies, are characterized by an expectorant effect. Berlin-Chemie for children is the most effective drug from large number analogues, the degree of purification of the determining active component is higher. When using analogues, carefully read the instructions for use.

Useful video

For more information on the use of Bromhexine Berlin Chemie, watch the following video:

Conclusion

Bromhexine Berlin Hemi syrup for children is effective, simple and easy to use.
Among many forms, the solution is popular for eliminating cough in childhood.
Distinctive advantages: ease of use, neutral smell and taste, safe composition.
Taking the syrup, according to the instructions for use, speeds up the process of clearing the bronchi of mucus, which helps to quickly cope with the disease.

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oral solution

Owner/Registrar

PHARMSTANDARD-LEKSREDSTVA, OJSC

International Classification of Diseases (ICD-10)

E84 Cystic fibrosis J04 Acute laryngitis and tracheitis J15 Bacterial pneumonia, not elsewhere classified J20 Acute bronchitis J37 Chronic laryngitis and laryngotracheitis J42 Chronic bronchitis, unspecified J45 Asthma R05 Cough

Pharmacological group

Mucolytic and expectorant

pharmachologic effect

Mucolytic agent with expectorant action. Reduces viscosity bronchial secretion due to the depolarization of the acidic polysaccharides it contains and stimulation of the secretory cells of the bronchial mucosa, which produce a secretion containing neutral polysaccharides. It is believed that bromhexine promotes the formation of surfactant.

Pharmacokinetics

Bromhexine is rapidly absorbed from the gastrointestinal tract and undergoes intensive metabolism during the “first pass” through the liver. Bioavailability is about 20%. U healthy patients Cmax in plasma is determined after 1 hour.

Widely distributed in body tissues. About 85-90% is excreted in the urine, mainly in the form of metabolites. Ambroxol is a metabolite of bromhexine.

The binding of bromhexine to plasma proteins is high. T1/2 in the terminal phase is about 12 hours.

Bromhexine penetrates the BBB. In small quantities it penetrates the placental barrier.

Only small quantities excreted in urine with T 1/2 6.5 hours.

The clearance of bromhexine or its metabolites may be reduced in patients with severe hepatic or renal impairment.

Diseases of the respiratory tract accompanied by the formation of difficult-to-discharge viscous secretions: tracheobronchitis, Chronical bronchitis with a broncho-obstructive component, bronchial asthma, cystic fibrosis, chronic pneumonia.

Increased sensitivity to bromhexine.

From the outside digestive system: dyspeptic symptoms, transient increase in the activity of liver transaminases in the blood serum.

From the side of the central nervous system: headache, dizziness.

Dermatological reactions: increased sweating, skin rash.

From the respiratory system: cough, bronchospasm.

special instructions

At peptic ulcer stomach, as well as when indicated stomach bleeding history of bromhexine should be used under medical supervision.

Use with caution in patients suffering from bronchial asthma.

Bromhexine is not used simultaneously with medicines containing codeine, because this makes it difficult to cough up thin mucus.

Used as part of combination drugs plant origin With essential oils(including eucalyptus oil, anise oil, peppermint oil, menthol).

Use during pregnancy and breastfeeding

During pregnancy and lactation, bromhexine is used in cases where the expected benefit to the mother outweighs the potential risk to the fetus or child.

Drug interactions

Bromhexine is incompatible with alkaline solutions.

Orally for adults and children over 10 years old - 8 mg 3-4 times a day. Children under 2 years of age - 2 mg 3 times a day; at the age of 2 to 6 years - 4 mg 3 times a day; at the age of 6 to 10 years - 6-8 mg 3 times a day. If necessary, the dose can be increased for adults to 16 mg 4 times / day, for children - up to 16 mg 2 times / day.

In the form of inhalations, adults - 8 mg, children over 10 years old - 4 mg, aged 6-10 years - 2 mg. At the age of up to 6 years - used in doses of up to 2 mg. Inhalations are carried out 2 times a day.

The therapeutic effect may appear on days 4-6 of treatment.

Respiratory tract ailments accompanied by the presence of cough, especially these pathologies, are often found in pediatrics. The drug Bromhexine Berlin Chemy Syrup has an excellent mucolytic effect; thanks to this property, from the first days of use, the baby can easily expectorate, clearing the airways of mucus.

Bromhexine is often used for children; carefully read the instructions and strictly follow the described rules. Never exceed the dosage; the high effectiveness of the medication is proven by many positive reviews from satisfied patients.

Pharmacological properties

Diseases of the upper, lower respiratory systems accompanied by a cough, it can be dry or wet. The main reason for the appearance of pathology is a malfunction of the bronchi; it appears in an increase in the production of special mucus increased viscosity. The lungs try to get rid of the problem by coughing.

In a normal state, mucus has antibacterial properties; during illness, it is poorly excreted; it is required intensive therapy. In such a situation, the use of antispasmodic and mucolytic drugs is required. The main purpose of medications is to liquefy mucus and remove it from the lungs by stimulating the functioning of the bronchi. Bromhexine shows excellent results; for small children, the drug is most often used in the form of syrup. Others can take it in the form of pills, drops, tablets.

Bromhexine reduces sputum viscosity due to the rapid breaking of bonds between mucus polysaccharides, contributing to an increase in bronchial more liquid secretion. The medication is prescribed for dry, debilitating cough to alleviate the baby’s condition.

Composition and release form

The main component of the drug is bromhexine hydrochloride, which has a strong mucolytic and expectorant effect. It is isolated from a special plant.

Additional components include:

glucite,
succinic acid,
propylene glycol,
sodium benzoate,
purified water,
apricot flavoring.

The last ingredients are responsible for the pleasant taste, aroma of the product, and the desired consistency. Bromhexine is produced in the form of syrup; each dark glass bottle contains 100 ml of the product. Additionally, the package contains a measuring spoon to help you measure correctly. required quantity medicinal product.

Indications for use

Bromhexine is highly effective and has a secretomotor, expectorant, and antitussive effect. In most cases, the medication is used to treat acute and chronic respiratory tract ailments, all of which are accompanied by dry lingering cough or wet with difficult sputum discharge. The drug is used to treat the following diseases:

spicy , ;
infectious diseases of the respiratory tract, which are complications of pharyngitis, tracheitis;
cystic fibrosis;
tuberculosis;
spicy;
emphysema;
congenital pathology of the bronchopulmonary system;
chronic and;
chronic nasopharyngitis;
pneumoconiosis.

Contraindications

In most cases, Bromhexine is well tolerated by children; it is considered one of the most safe medicines. Do not forget that this is a potent drug and has few contraindications. The main ones include:

individual sensitivity to the components of the drug;
Bromhexine is prohibited for children with serious pathologies liver and kidneys;
children under two years old;
stomach bleeding and other gastrointestinal pathologies.

Possible side effects

Before use, be sure to read the instructions. Exceeding the dosage, individual intolerance can cause mild allergic reaction in the baby: rashes on the body, itching, rash. Sometimes headaches, dizziness, etc. are noted. If you notice a pathology, immediately stop taking the medication and consult a doctor for help. You may need to take antihistamines.

Dosage and frequency of administration

Bromhexine can be prescribed from birth (only after consultation with a doctor). Dosage:

children from two to six years old – 4 ml three times a day;
from six to fourteen years – 8 ml three times a day.

Small children are prescribed the drug only in syrup form. The product has a pleasant taste and aroma, syrup is easier to give than pills. The drug is prescribed with caution to children with diabetes; the medication includes flavoring and sugar.

Interaction with other drugs

The instructions for Bromhexine state that it cannot be combined with drugs intended to suppress cough (Stoptusin, Codelac and others). Interactions between medicinal products can lead to unpleasant congestion in the lungs. As a result of such pathology it becomes inflammatory process, propagation of infection. In some cases, damage to the bronchial tree may occur.

The medication is allowed to be used together with insulin, corticosteroids, heart medications, and bronchodilators.

Effective analogues

The modern pharmacological industry produces a lot of drugs that are similar in composition and effect. Before replacing Bromhexine, be sure to consult your pediatrician. To analogues effective drug include the following medications:

Abrol;
Gedelix;
Septolete;
Travisil;
Mukaltin;
Doctor Mom;
Alteyka;
Ambroxol;
Falimint;
Helpex;
Balm Ho;
Pectoral and others.

The main analogue of Bromhexine is Ambroxol, the same name is given to the substance into which the medicine is converted after it enters the baby’s body. Other medications are similar to the medicinal product and differ in price and popularity. Please note these aspects before purchasing.

How to give to a newborn? Find out the rules of use and dosage.

How to treat a cold in a child folk remedies written on the page.

Read here about how to provide first aid and what to do in case of a concussion in children.

Storage conditions and periods

Store Bromhexine Berlin Hemi in a place for no more than five years, protected from direct sun rays. The optimal temperature is no more than 30 degrees. Do not use the drug after the expiration date. Opening the bottle obliges you to use the syrup for two months, after which the product becomes unusable.

Bromhexine has been on the market for more than 15 years and has earned the recognition of parents; they choose it to treat their children. The price of domestic syrup is 45 rubles, similar remedy Berlin Hemi costs 125 rubles per bottle.

P N013480/01 dated 08/22/2011

Tradename:

Bromhexine 4 Berlin - Hemi

International nonproprietary name:

bromhexine

Chemical name:

N- (2-amino-3,5 - dibromobenzyl) -N- methylcyclohexanamine hydrochloride

Dosage form Bromhexine 4 Berlin - Hemi:

oral solution

Composition per 100 ml solution Bromhexine 4 Berlin - Hemi:

Active substance: bromhexine hydrochloride - 0.08 g;

Excipients: propylene glycol - 25.00 g, sorbitol - 40.00 g, aromatic substance concentrate with the smell of apricot - 0.05 g, hydrochloric acid 0.1 M (3.5%) solution - 0.156 g, purified water - 49.062 g.

Description Bromhexine 4 Berlin - Hemi:

transparent, colorless, slightly viscous liquid with a characteristic apricot odor.

Pharmacotherapeutic group:

mucolytic expectorant.

Code ATX:

R05CB02.

Pharmacological properties

Pharmacodynamics

Bromhexine has a mucolytic (secretolytic) and expectorant effect. Reduces the viscosity of sputum; activates ciliated epithelium, increases the volume of sputum and improves its discharge.

Pharmacokinetics

When taken orally, it is almost completely (99%) absorbed into the gastrointestinal tract for 30 minutes. Bioavailability - about 80%. Binds to plasma proteins by 99%. Penetrates through the placental and blood-brain barriers. Penetrates breast milk. In the liver it undergoes demethylation and oxidation, metabolized to ambroxol. Half-life (T 1/2) equal to 16 hours (due to slow reverse diffusion from tissues). Excreted by the kidneys in the form of metabolites. For severe renal failure T 1/2 can increase.

Indications for use Bromhexine 4 Berlin - Hemi

Acute and chronic bronchopulmonary diseases accompanied by the formation of high-viscosity sputum (tracheobronchitis, pneumonia, obstructive bronchitis, bronchiectasis, bronchial asthma, emphysema, cystic fibrosis, tuberculosis, pneumoconiosis).

Contraindications

Hypersensitivity to the components of the drug;

Peptic ulcer (in the acute stage);

Pregnancy (first trimester);

Lactation period;

Congenital fructose intolerance.

Carefully

renal and/or liver failure;

bronchial diseases accompanied by excessive accumulation of secretions;

history of gastric bleeding;

children under 2 years of age.

Use during pregnancy and lactation

The use of the drug in the first trimester of pregnancy is contraindicated. In II andIIItrimesters of pregnancy, the use of the drug is possible only if the expected benefit to the mother exceeds possible risk for the fetus. The use of the drug during lactation is contraindicated.

Directions for use and doses Bromhexine 4 Berlin - Hemi

Oral solution.

1 measuring spoon contains 5 ml of solution.

Adults and teenagers over 14 years of age: 3 times a day, 2-4 scoops (24-48 mg of bromhexine per day).

Children from 6 to 14 years old, as well as patients weighing less than 50 kg: 3 times a day, 2 scoops (24 mg of bromhexine per day).

Children from 2 to 6 years old: 3 times a day, 1 measuring spoon (12 mg of bromhexine per day).

Children under 2 years old: 3 times a day 1/2 measuring spoon (6 mg bromhexine per day). In case of limited renal function or severe liver damage, the drug should be used with longer intervals between doses or in a reduced dose.

Side effect

The frequency is classified according to headings, depending on the occurrence of the case: very often (>1/10), often (<1/10-<1 /100), нечасто (<1/100-<1/1000), редко (<1/1000-<1/10000), очень редко (<1/10000), включая отдельные сообщения.

Digestive system disorders:

Infrequently:nausea, vomiting, diarrhea, abdominal pain;

Immune system disorders:

Infrequently:fever, hypersensitivity reactions (skin rash, angioedema, respiratory failure, itching, urticaria);

Very rarely:anaphylactic reactions up to shock.

Disorders of the skin and subcutaneous tissues:

Very rarely:Stevens-Johnson syndrome.

If side effects occur, stop taking the drug and consult a doctor.

Overdose

Symptoms: nausea, vomiting and other gastrointestinal disorders. Treatment: there is no specific antidote. In case of overdose, it is necessary to induce vomiting, and then give the patient liquid (milk or water). Gastric lavage is recommended within 1-2 hours after taking the drug.

Interaction with other drugs

Bromhexine 4 Berlin-Chemie can be prescribed simultaneously with other drugs used in the treatment of bronchopulmonary diseases.

With the combined use of Bromhexine 4 Berlin-Chemie and antitussives that suppress the cough reflex (including those containing codeine), due to a weakening of the cough reflex, there may be a risk of congestion.

Bromhexine 4 Berlin-Chemie promotes the penetration of antibiotics (erythromycin, cephalexin, oxytetracycline, ampicillin, amoxicillin) into the lung tissue.

special instructions

To maintain the secretolytic effect of the drug Bromhexine 4 Berlin-Chemie during the period of taking the drug, it is necessary to ensure that sufficient fluid enters the body.

In cases of impaired bronchial motility or with a significant volume of sputum secreted (for example, in rare malignant ciliary syndrome), the use of Bromhexine 4 Berlin-Chemie requires caution due to the risk of retention of secretions in the respiratory tract. The use of Bromhexine 4 Berlin-Chemie in children under 2 years of age is possible only under the supervision of a physician.

Instructions for patients with diabetes: 5 ml of solution (1 scoop) contains 2 g of sorbitol (equivalent to 0.5 g of fructose), which corresponds to 0.17 bread units.

Release form Bromhexine 4 Berlin - Hemi

Oral solution 4 mg/5 ml.

60 or 100 ml of solution in dark glass bottles with a screw-on plastic or aluminum stopper with a sealing gasket. 1 bottle complete with a measuring spoon along with instructions for use in a cardboard box.

Storage conditions

At a temperature not higher than 25 °C.

Keep the medicine out of the reach of children.

Mucolytic agents.

Compound

Active ingredient: Bromhexine.

Manufacturers

Berlin-Chemie AG (Germany), Berlin-Chemie AG/Menarini Group (Germany)

pharmachologic effect

Mucolytic, expectorant, antitussive.

Causes depolarization of mucoprotein and mucopolysaccharide polymer molecules (mucolytic effect).

Stimulates the production of endogenous surfactant, which ensures the stability of alveolar cells during breathing, their protection from unfavorable factors, improving the rheological properties of bronchopulmonary secretion, its sliding along the epithelium and the release of sputum from the respiratory tract.

When taken orally within 30 minutes, it is almost completely absorbed.

In plasma it binds to proteins.

Penetrates through the BBB and placental barriers.

In the liver it undergoes demethylation and oxidation.

Excreted by the kidneys.

May accumulate with repeated use.

Side effect

Gastrointestinal disorders (nausea, vomiting, dyspepsia, exacerbation of peptic ulcer), increased aminotransferase activity, allergic skin reactions, angioedema.

Indications for use

Acute and chronic diseases of the bronchi and lungs with impaired sputum discharge.

Contraindications

Hypersensitivity, pregnancy (especially in the first trimester), breastfeeding (must be suspended for the period of treatment).

Directions for use and dosage

Inside, with liquid.

Adults and adolescents over 14 years old - 23-47 drops 3 times a day; children from 6 to 14 years old and patients whose body weight is below 50 kg - 23 drops 3 times a day, up to 6 years - 12 drops 3 times a day.

Patients with severe renal failure should reduce the single dose or increase the interval between doses.

Overdose

No data.

Interaction

Promotes the penetration of antibiotics (erythromycin, cephalexin, oxytetracycline) into the lung tissue.

special instructions

Prescribed with caution for peptic ulcers of the stomach and duodenum.