Benzylpenicillin for inflammation of the female organs. Benzylpenicillin - description of the drug, instructions for use, reviews. Instructions for medical use
1 bottle of powder for preparation injection solution contains 0.6 g (1 million IU) or 3 g (5 million IU) benzylpenicillin in the form sodium salt, in packing 1 and 50 pcs.
pharmachologic effect
pharmachologic effect- bactericidal, antibacterial.Indications for the drug Benzylpenicillin
Severe generalized infections (meningitis, septicemia, disseminated gonococcal infection), streptococcal endocarditis, congenital syphilis, abscesses, infections respiratory tract(pneumonia), skin (erysipelas), lymphadenitis and lymphangitis, osteomyelitis, anthrax, tetanus, gas gangrene.
Contraindications
History of hypersensitivity to penicillins.
Side effects
Allergic reactions ( acute reactions hypersensitivity occurs 1-30 minutes after taking the drug), damage to the central nervous system (convulsions) with rapid injection of high doses.
Interaction
Probenecid, by reducing renal excretion, increases blood levels.
Directions for use and doses
Dosage varies depending on the type and severity of the infection; Approximate recommended doses: adults - 1.8-3.6 g (3-6 million IU) per day in 4 (6) divided doses. At severe infections(meningitis, septicemia) - up to 200 (300) mg/kg (0.33-0.5 million IU/kg) per day in 4-6 divided doses. In these cases, treatment begins with a slow intravenous injection or a rapid infusion (20-40 ppm, using 5% glucose as a diluent). Children: 30-90 mg/kg (50,000-150,000 IU/kg) per day in 4-6 divided doses. This corresponds to approximately 240 mg 4 times daily for children 5 months to 2 years; 300-600 mg 4 times a day for children from 2 to 6 years old and 450-900 mg 4 times a day for children 7-12 years old. For severe infections (meningitis, septicemia) - up to 300 mg/kg (0.5 million IU/kg) per day in 4-6 doses. In these cases, treatment begins with a slow intravenous injection or a rapid infusion (20-40 minutes, using 5% glucose as a diluent). Benzylpenicillin can also be used intramuscularly. Dilution of benzylpenicillin for infusion should be carried out immediately before use, since the activity of the antibiotic quickly decreases in infusion solutions. The duration of treatment depends on the indications and clinical picture. Recommended doses for individual diseases are: meningitis and/or septicemia caused by meningococci - 180-240 mg/kg (0.3-0.4 million IU/kg) per day in 4-6 doses, in the form of a slow IV injection or infusion over minimum 5 days; meningitis and/or septicemia caused by pneumococci - 240-300 mg/kg (0.4-0.5 million IU/kg) per day in 4-6 divided doses, as a slow IV injection or infusion over at least 10 days; infections caused by clostridia - 9-12 g (15-20 million IU) per day for adults and 180 mg/kg (0.3 million IU/kg) per day for 1 week as an addition to antitoxin therapy; streptococcal endocarditis - 6-12 g (10-20 million IU) per day for adults and 180 mg/kg (0.3 million IU) - for children for 2-4 weeks; congenital syphilis - 30 mg/kg (50,000 IU/kg) per day IM or IV in 2 doses for 2 weeks.
Storage conditions for the drug Benzylpenicillin
In a place protected from light, at a temperature not exceeding 30 °C.Keep out of the reach of children.
Shelf life of the drug Benzylpenicillin
4 years. 4 years; prepared solution for injection 24 hours (in the refrigerator 72 hours), for infusion - 12 hours (in the refrigerator - 24 hours).Do not use after the expiration date stated on the package.
Instructions for medical use
Synonyms of nosological groups
| Category ICD-10 | Synonyms of diseases according to ICD-10 |
|---|---|
| A35 Other forms of tetanus | Hydrophobia (hydrophobia) |
| Clostridia wounds | |
| Muscle spasms due to tetanus | |
| Tetanus | |
| Tetanus local | |
| Tetanus | |
| A41.9 Septicemia, unspecified | Bacterial septicemia |
| Severe bacterial infections | |
| Generalized infections | |
| Generalized systemic infections | |
| Generalized infections | |
| Wound sepsis | |
| Septic-toxic complications | |
| Septicopyemia | |
| Septicemia | |
| Septicemia/bacteremia | |
| Septic diseases | |
| Septic conditions | |
| Septic shock | |
| Septic condition | |
| Toxic-infectious shock | |
| Septic shock | |
| Endotoxin shock | |
| A46 Erysipelas | Erysipelas |
| A53.9 Syphilis, unspecified | Syphilis |
| Tertiary syphilis | |
| A54 Gonococcal infection | Gonococcal infections |
| Disseminated gonococcal infection | |
| Disseminated gonorrheal infection | |
| B99 Other infectious diseases | Infections (opportunistic) |
| Infections due to immunodeficiency | |
| Opportunistic infections | |
| I33 Acute and subacute endocarditis | Postoperative endocarditis |
| Early endocarditis | |
| Endocarditis | |
| Endocarditis acute and subacute | |
| I88 Nonspecific lymphadenitis | Lymphadenitis |
| Lymphadenitis of nonspecific etiology | |
| Superficial lymphadenitis | |
| J06 Acute infections upper respiratory tract of multiple and unspecified localization | Bacterial infections of the upper respiratory tract |
| Bacterial respiratory infections | |
| Pain due to colds | |
| Pain in infectious and inflammatory diseases of the upper respiratory tract | |
| Viral respiratory disease | |
| Viral respiratory tract infections | |
| Inflammatory disease of the upper respiratory tract | |
| Inflammatory diseases of the upper respiratory tract | |
| Inflammatory diseases of the upper respiratory tract with difficult to separate sputum | |
| Inflammatory diseases of the respiratory tract | |
| Secondary infections with influenza | |
| Secondary infections due to colds | |
| Influenza conditions | |
| Difficulty secreting sputum in acute and chronic diseases respiratory tract | |
| Upper respiratory tract infections | |
| Infections upper sections respiratory tract | |
| Respiratory tract infections | |
| Respiratory and lung infections | |
| ENT infections | |
| Infectious and inflammatory diseases of the upper respiratory tract | |
| Infectious and inflammatory diseases of the upper respiratory tract and ENT organs | |
| Infectious and inflammatory diseases of the upper respiratory tract in adults and children | |
| Infectious and inflammatory diseases of the upper respiratory tract | |
| Infectious inflammation of the respiratory tract | |
| Respiratory tract infection | |
| Qatar of the upper respiratory tract | |
| Catarrhal inflammation of the upper respiratory tract | |
| Catarrhal disease of the upper respiratory tract | |
| Catarrhal phenomena from the upper respiratory tract | |
| Cough in diseases of the upper respiratory tract | |
| Cough with a cold | |
| Fever due to influenza | |
| ARVI | |
| acute respiratory infections | |
| Acute respiratory infection with symptoms of rhinitis | |
| Acute respiratory infection | |
| Acute infectious-inflammatory disease of the upper respiratory tract | |
| Acute cold | |
| Acute respiratory disease | |
| Acute respiratory disease of influenza nature | |
| Sore throat or nose | |
| Cold | |
| Colds | |
| Colds | |
| Respiratory infection | |
| Respiratory viral infections | |
| Respiratory diseases | |
| Respiratory infections | |
| Recurrent respiratory tract infections | |
| Seasonal colds | |
| Seasonal colds | |
| Frequent colds and viral diseases | |
| J85 Abscess of the lung and mediastinum | Lung abscess |
| Lung abscess | |
| Bacterial lung destruction | |
| L02 Skin abscess, boil and carbuncle | Abscess |
| Skin abscess | |
| Carbuncle | |
| Skin carbuncle | |
| Furuncle | |
| Skin boil | |
| Furuncle of the external auditory canal | |
| Furuncle of the auricle | |
| Furunculosis | |
| Boils | |
| Chronic recurrent furunculosis | |
| M60.0 Infectious myositis | Muscle abscess |
| Soft tissue infections | |
| Infectious myositis | |
| Pyomyositis | |
| Specific infectious processes in soft tissues | |
| M65.0 Tendon sheath abscess | Soft tissue infections |
| M65.1 Other infectious tenosynovitis | Soft tissue infections |
| Tenosynovitis infectious | |
| M71.0 Abscess of bursa | Soft tissue infections |
| M71.1 Other infectious bursitis | Bacterial bursitis |
| Infectious bursitis | |
| Soft tissue infections | |
| N74.2 Inflammatory diseases of women pelvic organs caused by syphilis (A51.4+, A52.7+) | Syphilis |
| N74.3 Gonococcal inflammatory diseases female pelvic organs (A54.2+) | Gonorrheal diseases |
| Gonorrhea | |
| Gonococcal urethritis | |
| R09.1 Pleurisy | Calcification of the pleura |
| Acute pleurisy | |
| R78.8.0* Bacteremia | Bacteremia |
| Persistent bacteremia |
Benzylpenicillin: instructions for use and reviews
Latin name: Benzylpenicillin
ATX code: J01CE01
Active substance: benzylpenicillin
Manufacturer: JSC "Biosintez", JSC "Biokhimik", JSC "Kraspharma" (Russia), "Kievmedpreparat" (Ukraine), Mapichem (Switzerland)
Updating the description and photo: 13.08.2019
Benzylpenicillin – antibacterial drug penicillin group.
Release form and composition
Benzylpenicillin is produced in the form of a powder for the preparation of a solution for injection (in 10 ml bottles).
1 bottle contains benzylpenicillin sodium salt, 500 thousand IU and 1 million IU.
Pharmacological properties
Pharmacodynamics
Benzylpenicillin is an antibiotic belonging to the group of biosynthetic penicillins. It is active against gram-positive microorganisms (Streptococcus spp., including Streptococcus pneumoniae, strains of Staphylococcus spp. that do not produce penicillinase), Actinomyces spp., Corynebacterium diphtheria, anthrax bacilli, anaerobic spore-forming bacilli, Spirochaeta spp., Treponema spp., gram-negative cocci (Neisseria gonorrhoeae, Neisseria meningitidis). Strains of staphylococci that produce penicillinase are resistant to the action of benzylpenicillin, since this enzyme promotes the destruction of benzylpenicillin molecules.
The drug does not demonstrate pharmacological activity against most protozoa, gram-negative bacteria, viruses, rickettsia (Rickettsia spp.).
Pharmacokinetics
At parenteral administration Benzylpenicillin is well absorbed, does not have a cumulative effect and is quickly eliminated from the body through the kidneys.
When administered intramuscularly, the maximum content of the substance in the blood is recorded after 30–60 minutes, and after 3–4 hours only traces of benzylpenicillin are detected in the blood.
The concentration range and duration of circulation of benzylpenicillin in the blood are determined by the size of the administered dose. The drug penetrates well into body fluids and tissues: cerebrospinal fluid Normally it is present in clinically insignificant quantities. Inflammation of the meningeal membranes leads to an increase in the concentration of benzylpenicillin in the cerebrospinal fluid.
Indications for use
- Severe generalized infections (meningitis, septicemia, disseminated gonococcal infection);
- Infections of the respiratory tract (pneumonia) and skin (erysipelas);
- Congenital syphilis;
- Streptococcal endocarditis;
- Tetanus;
- Abscesses;
- Lymphadenitis and lymphangitis;
- Anthrax;
- Osteomyelitis;
- Gas gangrene.
Contraindications
According to the instructions, Benzylpenicillin is contraindicated in case of hypersensitivity to penicillins.
The drug is prescribed with caution to lactating and pregnant women.
Instructions for use of Benzylpenicillin: method and dosage
The dosage of benzylpenicillin is determined by the type and severity of the infection.
- Adults: 1800-3600 mg (3-6 million IU) per day, divided into 4-6 doses. For severe infections (septicemia, meningitis), the dosage is calculated based on weight - up to 200-300 mg/kg (330-500 thousand IU/kg) per day. In this case, therapy should begin slowly intravenous injection or with rapid infusion using 5% glucose as a diluent;
- Children: at the rate of 30-90 mg/kg (50-150 thousand IU/kg) per day in 4-6 divided doses. For severe infections, the dosage can be increased to 300 mg/kg (500 thousand IU/kg).
Benzylpenicillin can also be used intramuscularly, diluting the drug immediately before use, since its activity in infusion solutions quickly decreases. The duration of therapy is determined by the indications and clinical picture.
- Septicemia and meningitis caused by meningococci: for at least 5 days as a slow intravenous injection or infusion of 180-240 mg/kg (300-400 thousand IU/kg) per day in 4-6 divided doses;
- Septicemia and meningitis caused by pneumococci: for at least 10 days as a slow intravenous injection or infusion of 240-300 mg/kg (400-500 thousand IU/kg) per day in 4-6 divided doses;
- Infections caused by clostridia: for 7 days as an addition to antitoxin therapy, 9,000-12,000 mg (15-20 million IU) per day for adults and 180 mg/kg (300 thousand IU/kg) for children;
- Streptococcal endocarditis: for 14-28 days, 6,000-12,000 mg (10-20 million IU) per day for adults and 180 mg/kg (300 thousand IU/kg) for children;
- Congenital syphilis: in 2 doses for 14 days, intramuscularly or intravenously, 30 mg/kg (50 thousand IU/kg) per day.
Side effects
When using Benzylpenicillin, allergic reactions may occur, manifested as:
- Interstitial nephritis, rash on mucous membranes, angioedema, urticaria, hyperthermia, skin rash, arthralgia, eosinophilia, bronchospasm (often);
- Anaphylactic shock (rare).
At the beginning of the course of therapy (especially congenital syphilis) Benzylpenicillin can cause fever, chills, exacerbation of the disease, increased sweating, Jarisch-Herxheimer reactions.
From local reactions most likely to develop pain and hardness in the area intramuscular injection.
With long-term use of benzylpenicillin, dysbacteriosis and the development of superinfection may occur.
Overdose
An overdose of benzylpenicillin can be suspected based on symptoms such as seizures and impaired consciousness. In this case, immediately discontinue the drug and prescribe symptomatic therapy.
special instructions
In cases where no effect is observed 2-3 days (maximum 5 days) after starting the use of benzylpenicillin, it is necessary to switch to the use of other antibiotics or combination therapy.
Because of existing risk development of fungal infections during drug therapy; if necessary, the doctor prescribes antifungal drugs medicines.
To avoid the emergence of resistant strains of pathogens, you should avoid using insufficient doses of the drug or stopping treatment too early.
Impact on the ability to drive vehicles and complex mechanisms
For impaired renal function
In patients with renal dysfunction, the drug is used with caution.
Drug interactions
Probenecid inhibits the tubular secretion of benzylpenicillin, thereby increasing the level of the latter in the blood plasma and increasing the half-life.
When combined with antibiotics that have a bacteriostatic effect (tetracycline, macrolides, lincosamides, chloramphenicol), the bactericidal effect of benzylpenicillin is reduced.
The drug enhances the effectiveness of indirect anticoagulants by reducing the prothrombin index and inhibiting intestinal microflora and makes less effective application ethinyl estradiol (risk of breakthrough bleeding), drugs in which the end product of metabolism is para-aminobenzoic acid, and oral contraceptives.
Non-steroidal anti-inflammatory drugs, diuretics, phenylbutazone, tubular secretion blockers, allopurinol suppress tubular secretion, thereby increasing the concentration of benzylpenicillin when local application.
The combination of the drug with allopurinol increases the risk of allergic reactions ( skin rashes). The combination of benzylpenicillin and bactericidal antibiotics (including aminoglycosides, cephalosporins, rifampicin, vancomycin) has a synergistic effect.
Analogs
According to the mechanism of action, analogues of Benzylpenicillin are: Benzathinebenzylpenicillin, Benzicillin-1 (-3, -5), Bicillin-1 (-3, -5), Moldamine, Ospen 750, Retarpen, Star-Pen, Phenoxymethylpenicillin.
Terms and conditions of storage
Shelf life – 4 years at temperatures up to 30 °C. The shelf life of an injection solution prepared from powder is 24 hours (in the refrigerator – 72 hours), a solution for infusion – 12 hours (in the refrigerator – 24 hours).
Composition and release form of the drug
Powder for solution for injection fine-crystalline, white, with a weak characteristic odor.
Bottles of 10 ml (1) - cardboard boxes.
Bottles of 10 ml (50) - cardboard boxes.
pharmachologic effect
Antibiotic of the group of biosynthetic penicillins. It has a bactericidal effect by inhibiting the synthesis of the cell wall of microorganisms.
Active against gram-positive bacteria: Staphylococcus spp., Streptococcus spp. (including Streptococcus pneumoniae), Corynebacterium diphtheriae, Bacillus anthracis; gram-negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis; anaerobic spore-forming rods; as well as Actinomyces spp., Spirochaetaceae.
Strains of Staphylococcus spp. that produce penicillinase are resistant to the action of benzylpenicillin. Destroys in an acidic environment.
Benzylpenicillin potassium salt is used only intramuscularly and subcutaneously, in the same doses as benzylpenicillin sodium salt.
Benzylpenicillin novocaine salt is used only intramuscularly. Average therapeutic dose for adults: single - 300,000 units, daily - 600,000 units. Children under 1 year of age - 50,000-100,000 units/kg/day, over 1 year of age - 50,000 units/kg/day. Frequency of administration 3-4 times/day.
The duration of treatment with benzylpenicillin, depending on the form and severity of the disease, can range from 7-10 days to 2 months or more.
Side effects
From the outside digestive system: diarrhea, nausea, vomiting.
Effects due to chemotherapeutic action: vaginal candidiasis, oral candidiasis.
From the side of the central nervous system: when using benzylpenicillin in high doses, especially with endolumbar administration, the development of neurotoxic reactions is possible: nausea, vomiting, increased reflex excitability, symptoms of meningism, convulsions, coma.
Allergic reactions: fever, urticaria, skin rash, rash on mucous membranes, joint pain, eosinophilia, angioedema. Cases described anaphylactic shock with fatal outcome.
Drug interactions
Probenecid reduces the tubular secretion of benzylpenicillin, resulting in an increase in the concentration of the latter in the blood and an increase in the half-life.
At simultaneous use with antibiotics that have a bacteriostatic effect (tetracycline), the bactericidal effect of benzylpenicillin is reduced.
special instructions
Use with caution in patients with impaired renal function, heart failure, predisposition to allergic reactions (especially with drug allergies), with hypersensitivity to cephalosporins (due to the possibility of developing cross-allergy).
If no effect is observed 3-5 days after the start of use, you should move on to the use of other antibiotics or combination therapy.
Due to the possibility of developing fungal superinfection, it is advisable to prescribe antifungal drugs when treating with benzylpenicillin.
It must be taken into account that the use of benzylpenicillin in subtherapeutic doses or early cessation of treatment often leads to the emergence of resistant strains of pathogens.
Pregnancy and lactation
Use during pregnancy is possible only if the expected benefit of therapy for the mother outweighs the potential risk to the fetus.
If it is necessary to use it during lactation, the issue of stopping breastfeeding should be decided.
Use in childhood
Can be used in children according to indications.
For impaired renal function
Use with caution in patients with impaired renal function.
Benzylpenicillin is an antibiotic from the group of biosynthetic penicillins. The drug has a bactericidal effect by inhibiting the synthesis of the cell wall of microorganisms.
Release form and composition
Benzylpenicillin is available in the form of a white, fine-crystalline powder for the preparation of a solution for injection. The powder has a weak characteristic odor. One bottle contains benzylpenicillin sodium salt 125,000, 250,000, 500,000 or 1,000,000 units.
Indications for use
The drug is prescribed for diseases caused by microorganisms that are sensitive to benzylpenicillin:
- Sepsis;
- Focal and lobar pneumonia;
- Pyemia;
- Septicemia;
- Empyema of the pleura;
- Meningitis;
- Septic endocarditis (acute and subacute);
- Biliary and urinary tract infections;
- Chronic and acute osteomyelitis;
- Angina;
- Diphtheria;
- Erysipelas;
- Scarlet fever;
- Actinomycosis;
- Gonorrhea;
- Syphilis;
- Blennorea;
- ENT diseases;
- Anthrax;
- Eye diseases;
- Purulent infections of soft tissues, skin and mucous membranes;
- Purulent-inflammatory diseases in obstetric and gynecological practice.
Contraindications
The use of benzylpenicillin is contraindicated increased sensitivity to the drug and other antibiotics from the group of cephalosporins and penicillins.
In patients with epilepsy, benzylpenicillin should not be administered endolumbarally.
Directions for use and dosage
The dosage regimen of the drug is individual. According to the instructions, benzylpenicillin is administered intravenously, intramuscularly, subcutaneously and endolumbarally.
Daily dose for adults (with intramuscular and intravenous administration) varies in the range of 250,000-60,000,000 units, for babies under one year old - from 50,000 to 100,000 units/kg, for children over one year old - 50,000 units/kg of body weight. If necessary, you can increase daily dose up to 200,000-300,000 units/kg, and for health reasons up to 500,000 units/kg. As a rule, the frequency of administration of the drug varies from 4 to 6 times a day.
The dosage of benzylpenicillin for the endolumbar route of administration depends on the disease and the severity of its course. Adults are prescribed 5000-10000 units, children - from 2000 to 5000 units. The powder is diluted at 0.9% NaCl solution or in special sterile water for injection at a rate of 1000 units/ml. Immediately before the injection, 5 to 10 ml of cerebrospinal fluid is removed and added to the antibiotic solution in a 1:1 ratio.
To puncture infiltrates, benzylpenicillin is used subcutaneously at the rate of 100,000-200,000 units per 1 ml of novocaine solution of 0.25-0.5% concentration.
The duration of treatment depends on the severity and form of the disease. On average, it ranges from 7-10 days to two months, and sometimes more.
Side effects
The following side effects may occur when using Benzylpenicillin:
- Nausea, vomiting and diarrhea from the digestive system;
- Oral and vaginal candidiasis caused by the chemotherapeutic effect of the drug;
- Increased reflex excitability, symptoms of meningism, convulsive states and even coma from the central nervous system;
- Rash on the skin and mucous membranes, joint pain, fever, urticaria, angioedema, eosinophilia and other allergic reactions, including fatal anaphylactic shock.
special instructions
Caution is required when using Benzylpenicillin in persons with heart failure and impaired renal function, as well as those with a predisposition to allergies (especially drug allergies).
If there is no therapeutic effect, 3-5 days after the start of treatment, you should turn to combination therapy or change the antibiotic.
When using benzylpenicillin, it is advisable to prescribe antifungal drugs due to the high likelihood of developing fungal superinfection.
It is necessary to strictly adhere to the dosages and duration of treatment specified in the instructions for benzylpenicillin, since subtherapeutic doses or early cessation of therapy can lead to the emergence of resistant strains of microorganisms.
Analogs
Structural analogues of the drug are:
- Benzylpenicillin novocaine salt;
- Penicillin G sodium salt;
- Benzylpenicillin-KMP.
Terms and conditions of storage
According to the instructions, benzylpenicillin should be stored in a dry place, protected from direct sun rays, at a temperature of no more than 10 °C. The shelf life of the antibiotic is 2 years.
Benzylpenicillin- antimicrobial agent for systemic use,
antibacterial, bactericidal.
It disrupts the synthesis of cell wall peptidoglycan and causes lysis of microorganisms.
Active against gram-positive bacteria (strains of Staphylococcus spp. that do not form penicillinase, Streptococcus spp., including Streptococcus pneumoniae), Corynebacterium diphtheriae, anaerobic spore-forming bacilli, anthrax bacilli, Actinomyces spp., as well as against gram-negative cocci (Neisseria meningitidis, Neisseria gonorrhoeae ), Treponema spp., Spirochaeta spp. Not effective against most gram-negative bacteria, rickettsia, viruses, protozoa, and fungi.
With intramuscular administration of sodium and potassium salts of benzylpenicillin, Cmax in the blood is achieved in 30-60 minutes; after 3-4 hours, traces of the antibiotic are detected in the blood. Benzylpenicillin novocaine salt is slowly absorbed and has a prolonged effect; after a single injection in the form of a suspension, the therapeutic concentration of penicillin in the blood remains for up to 12 hours. Binding to blood proteins is 60%. Penetrates well into organs, tissues and biological fluids, with the exception of cerebrospinal fluid, prostate. For inflammation meninges passes through the BBB. When instilled into the conjunctival sac in therapeutic concentrations, it is found in the stroma of the cornea (it practically does not penetrate into the moisture of the anterior chamber when applied topically). Therapeutic concentrations in the cornea and anterior chamber moisture are created by subconjunctival administration (the concentration in vitreous body does not reach therapeutic levels). With intravitreal administration, T1/2 is about 3 hours. It is excreted by the kidneys through glomerular filtration (approximately 10%) and tubular secretion (90%) unchanged. In newborns and children infancy excretion slows down when renal failure T1/2 increases to 4-10 hours.
Indications for use
A drug Benzylpenicillin used in the treatment of infections caused by microorganisms sensitive to the drug:- infections of the respiratory tract and ENT organs: tonsillitis, pneumonia, purulent pleurisy, diphtheria, scarlet fever, actinomycosis of the lungs;
- infections genitourinary system: cystitis, syphilis, gonorrhea, colpitis, endocervicitis, endometritis, adnexitis, salpingo-oophoritis;
- infections of the organ of vision: conjunctivitis, blepharitis, dacryocystitis;
- purulent infections skin and soft tissues;
- septic endocarditis, sepsis;
- osteomyelitis;
- wound infections;
- erysipelas;
- anthrax;
- meningitis;
- peritonitis;
- biliary tract infections.
Mode of application
Before administration it is necessary to carry out preliminary skin test on drug tolerability Benzylpenicillin and novocaine, provided that it is used for breeding, in the absence of contraindications to its implementation.The drug is administered intramuscularly, subcutaneously, intravenously (stream and drip), intrathecally, in the body cavity. The most common route of administration is intramuscular.
Intravenously: for infections moderate severity a single dose of the drug for adults is usually 250,000-500,000 units, daily - 1,000,000-2,000,000 units, for severe infections up to 10,000,000-20,000,000 units per day are administered, for gas gangrene - up to 40,000,000- 60,000,000 units. Usually the daily dose for children under 1 year of age is 50,000-100,000 units/kg, older
1 year - 50,000 units/kg, if necessary, the daily dose can be increased to 200,000-300,000 units/kg, for health reasons - up to 500,000 units/kg. The frequency of administration of the drug is 4-6 times a day. Benzylpenicillin solution is prepared immediately before use. For intravenous jet administration, a single dose (1,000,000-2,000,000 units) of the drug is dissolved in 5-10 ml of sterile water for injection or 0.9% sodium chloride solution and administered slowly over 3-5 minutes. For intravenous drip administration, 2,000,000-5,000,000 units of antibiotic are dissolved in 100-200 ml of 0.9% sodium chloride solution or 5% glucose solution and administered at a rate of 60-80 drops per minute.
The drug is administered intravenously 1-2 times a day, combined with intramuscular injections.
Intramuscularly: for moderate infections, a single dose of the drug for adults is usually 250,000-500,000 units, daily - 1,000,000-2,000,000 units, for severe infections up to 10,000,000-20,000,000 units per day are administered, for gas gangrene - up to 40,000,000-60,000,000 units. Typically, the daily dose for children under 1 year of age is 50,000-100,000 units/kg, over 1 year - 50,000 units/kg, if necessary, the daily dose can be increased to 200,000-300,000 units/kg, for health reasons - up to 500,000 units/kg. The frequency of administration of the drug is 4-6 times a day. For intramuscular administration, add 1-3 ml of sterile water for injection or 0.9% sodium chloride solution, or 0.5% novocaine solution to the contents of the bottle. The resulting solution is injected deep into the muscle in the upper outer quadrant of the buttock.
Subcutaneously: Benzylpenicillin is used to inject infiltrates at a concentration of 100,000-200,000 units in 1 ml of 0.25-0.5% novocaine solution. In the cavity (abdominal, pleural, etc.), a solution of benzylpenicillin is administered to adults at a concentration of 10,000-20,000 units per 1 ml, for children - 2,000-5,000 units per 1 ml. Dissolve in sterile water for injection or 0.9% sodium chloride solution. The duration of treatment is 5-7 days, followed by switching to intramuscular administration.
Intrathecally: the drug is administered when purulent diseases head, spinal cord, meninges.
Adults are prescribed a dose of 5,000-10,000 units, children over 1 year old - 2,000-5,000 units, administered slowly - 1 ml per minute, once a day. The drug is diluted in sterile water for injection or in 0.9% sodium chloride solution at the rate of 1,000 units per 1 ml. Before injection, 5-10 ml of cerebrospinal fluid is removed from the spinal canal and added to the antibiotic solution in equal proportions. Injections are repeated for 2-3 days, after which they switch to intramuscular administration.
Treatment of patients with syphilis and gonorrhea is carried out according to specially developed regimens.
Depending on the form and severity of the disease, benzylpenicillin is used from 7-10 days to 2 months or more (sepsis, septic endocarditis, etc.).
Side effects
Hypersensitivity reactions: skin rash, itching, fever, chills, arthralgia, edema, urticaria, multiforme exudative erythema, exfoliative dermatitis, angioedema, anaphylactic shock.From the respiratory system: bronchospasm.
From the central and peripheral nervous system: dizziness, headache, noise in ears. Endolumbar administration can cause neurotoxicosis (nausea, vomiting, symptoms of meningism, convulsions).
From the outside digestive tract: nausea, stomatitis, glossitis, diarrhea, pseudomembranous colitis, liver dysfunction.
From the genitourinary system: interstitial nephritis.
From the outside of cardio-vascular system: fluctuations blood pressure, violation of the pumping function of the myocardium.
From the side of blood and lymphatic system: eosinophilia, positive results Coombs test, hemolytic anemia, leukopenia, thrombocytopenia, agrunolocytosis.
Other: in weakened patients, newborns, elderly people with long-term treatment Superinfection may occur caused by drug-resistant microflora (yeast-like fungi, gram-negative microorganisms). Patients undergoing treatment for syphilis may experience a Jarisch-Herxheimer reaction secondary to bacteriolysis.
Contraindications
:Contraindications to the use of the drug Benzylpenicillin are: hypersensitivity to benzylpenicillin and other β-lactam antibiotics (penicillins, cephalosporins, carbapenems); bronchial asthma; hay fever; urticaria and others allergic diseases; epilepsy (for endolumbar administration); breastfeeding period.
Pregnancy
:Can be used during pregnancy Benzylpenicillin, if the expected benefit to the mother outweighs the potential risk to the fetus. Breastfeeding should be stopped during treatment.
Interaction with other drugs
Bactericidal antibiotics (including cephalosporins, vancomycin, rifampicin, aminoglycosides) - synergistic action, bacteriostatic (including macrolides, chloramphenicol, lincosamides, tetracyclines) - antagonism. Diuretics, allopurinol, tubular secretion blockers, NSAIDs reduce tubular secretion and increase the concentration of benzylpenicillin. Allopurinol increases the risk of developing allergic reactions(skin rash).Overdose
:Overdose symptoms Benzylpenicillin: convulsions, impaired consciousness.
Treatment: drug withdrawal, symptomatic therapy.
Storage conditions
Store in original packaging at a temperature not exceeding 25 °C out of the reach of children.Release form:
Benzylpenicillin - powder for solution for injection. 500,000 units or 1,000,000 units in bottles; in bottles No. 10 per pack.
Compound
:1 bottle contains sterile benzylpenicillin sodium salt - 500,000 units or 1,000,000 units.
Main settings
| Name: | BENZYLPENICILLIN |
| ATX code: | J01CE01 - |