Disturbed balance (about vaginal dysbiosis). Epigen spray genital herpes. We select inexpensive analogues. Instructions for use in the treatment and prevention of viral diseases Epigen intimate analogs
Pregnancy is a time when the most harmless “sore” can become big problem. Viral, bacterial and fungal infections can harm the baby growing in the womb. This is a serious risk of developmental defects, and sometimes early termination of pregnancy. Unfortunately, not all diseases can be completely cured, especially in a pregnant woman, for whom the range of medications is narrowed to a minimum. But sexual diseases such as cytomegalovirus and herpes can be maintained in a latent state. One of the most modern drugs with a wide spectrum of action aimed at fighting infections is Epigen Intim spray.
Is Epigen Intim spray allowed during pregnancy, including in the early stages?
Spray Epigen Intim is one of the few drugs local action, recommended for use throughout pregnancy for diseases of the genital area. This is explained by the following facts:
- The main active component of the drug, glycyrrhizic acid, is of natural origin. This substance is obtained by extraction from licorice root.
- Glycyrrhizic acid is practically not absorbed into the blood; therefore, the drug is not capable of harming the fetus or affecting the course of pregnancy.
The antiviral effect of glycyrrhiziric acid is based on its immunomodulatory properties. The mechanism of this action includes:
- stopping the reproduction of viruses in the initial stages of the disease;
- removal of virions (extracellular forms of the virus) from the outer shells, which prevents the introduction of the virus into living cells;
- stimulating the body's production of its own interferon and increasing local immunity.
In addition to antiviral, the described agent has other effects:
- antipruritic;
- anti-inflammatory;
- regenerating.
According to the instructions, Epigen Intim is allowed to be used throughout the entire period of pregnancy.
Indications and contraindications
Epigen Intim can be prescribed by a doctor as a primary medicine(in mild cases), and as part of complex therapy. The list of diseases in the fight against which Epigen Intim has proven its effectiveness is impressive. Among them:
- diseases provoked by the human papillomavirus, including those types that have a high risk of oncology;
- diseases caused by herpes virus types 1 and 2;
- diseases caused by the Varicella Zoster virus ();
- cytomegalovirus;
- vulvovaginal candidiasis (thrush);
- bacterial vaginosis;
- nonspecific colpitis.
Epigen Intim is also prescribed for preventive purposes. After all, the listed viruses, especially during pregnancy, when the expectant mother’s immunity is reduced for natural reasons, are more likely to manifest themselves in the form of:
- genital warts;
- various pathologies of the cervix (erosion, dysplasia, ectopia);
- relapse of an inflammatory disease caused by a virus.
The use of Epigen Intim spray and intimate hygiene products is also recommended for dryness, burning and other types of discomfort in the intimate area.
Intimate hygiene products
To enhance the effect of the spray or as preventative daily care, you can additionally use other products from the Epigen Intim line:
- gel for intimate hygiene- for daily care (in addition to glycyrrhizic acid, it contains lactic acid, which helps maintain the natural balance of vaginal microflora);
- intimate hygiene wipes - for express care (contains glycyrrhizic acid, lactic acid, hyaluronic acid);
- a special complex for moisturizing intimate areas.
The instructions for the drug list allergic reactions as the only contraindication and the corresponding side effect of the Epigen Intim line. Thus, in isolated cases, contact dermatitis may be observed at the sites where the drug is applied.
If you suspect the possibility of allergic manifestations, before using the drug, you should carry out a test spray, for example, on the wrist area and evaluate the result after 2 hours.
Instructions for correct use
The duration and frequency of use of the spray in each case is determined by the attending physician. As a rule, these indicators depend on a number of factors:
- etiology of the disease (viral, fungal or bacterial);
- severity and severity of infection;
- treatment or prevention is required.
Approximate spray treatment regimens, depending on the nature of the disease or condition requiring prevention, are described in the instructions as follows:
- For diseases caused by cytomegalovirus or genital herpes virus. The duration of the course is usually 2 weeks. The number of sprays of the drug per day is up to 5 times.
- If affected by Herpes simplex viruses (types 1 and 2) or Varicella zoster - 6 times a day for five days.
- For bacterial vaginitis, bacterial vaginosis and candidal vulvovaginitis (thrush), the drug is prescribed 3-4 injections daily for a course of 7 to 10 days.
- To sanitize the birth canal in late stages of pregnancy (37–38 weeks), as well as as a prophylactic agent at any stage of pregnancy, Epigen Intim is used 6 times daily for five days.
- If there is discomfort or dryness in the genital area, use the product twice a day for several weeks.
For intravaginal use, the kit includes a special nozzle
Rules for using Epigen Intim spray:
- The spray container should be shaken before use. During spraying, the bottle is held in vertical position.
- The surface to be treated can be pre-cleaned using special hygiene products(for example, intimate hygiene gel Epigen Intim).
- At local application the spray is sprayed onto the affected surface from a distance of 4–5 cm by pressing the spray button one or two times.
- For intravaginal use, the kit includes a special nozzle. With this application, the spray is injected twice.
Before and after use, the spray nozzle should be thoroughly rinsed. boiled water with soap and dry. Keep clean.
What can be replaced
Epigen Intim has no complete analogues. In some ways, the medications and intimate area care products described in the table have similar properties. The decision about the advisability of replacement should be made only by the attending physician.
Table: options for replacing Epigen Intim products
| Name | Active substance | Action | Release form | Purposes of application | Contraindications | Use during pregnancy |
| Panavir | Extract from potato tops shoots |
|
|
Treatment of viral infections |
|
The use of solution and gel during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus. |
| Spray for intimate areas(cosmetics) |
|
Individual intolerance to the components of the drug | Use is possible in the second and third trimester of pregnancy according to the indication “chronic cytomegalovirus infection in the acute stage” as part of complex therapy. | |||
| Lactic acid |
|
Cosmetical tools:
|
|
The use of Lactacid products is possible at any stage of pregnancy. |
Photo gallery: remedies for thrush and other genital diseases during pregnancy
Lactacid Femina - products for daily care of the intimate area based on lactic acid 
Panavir gel is used by expectant mothers only as prescribed by a doctor after weighing the risks and benefits 
Panavir Intim spray is not a medicine
Epigen intimate hygiene gel is one of the most popular products in its category, which is recommended for use by gynecologists. It does not contain aggressive components that irritate delicate skin. The use does not disrupt the “standard” microflora of the genital organs, which is so important for health. To what does the gel owe such advantages?
Epigen: not just cleanliness
Epigen - a well-known intimate gel - is designed specifically for intimate hygiene and care for the sensitive genital area. It is an effective prophylactic agent that prevents reproduction in the body pathogenic microorganisms, which provoke a decrease in immunity. Regular use of Epigen intimate hygiene gel restores tissue and produces an immunostimulating effect, increasing the activity and number of T-lymphocytes - cells responsible for the body's fight against foreign antibodies.
Gel eliminates unpleasant odors, relieves itching, soothes inflamed skin and eliminates the cause that caused such unpleasant sensations - viruses. The drug also restores vaginal microflora damaged by fungi. Thanks to this action, lactobacilli, useful and necessary for the body, begin to multiply more intensively and resist foreign microorganisms.
This gel also helps to cope with irritation and discomfort not related to health, but arising due to, for example, shaving the bikini area, wearing synthetic underwear, etc. The product provides freshness and comfort for the whole day and is suitable for frequent use. It can be used during pregnancy, breastfeeding and menstruation.
Composition of Epigen
Such a “magical” effect of the product is explained by its complex, balanced composition, which includes:
- phytosphynosines - substances of natural origin, extract useful elements from yeast cells. They have anti-inflammatory and antimicrobial effects;
- glycerin - moisturizes and softens the skin;
- lactic acid - supports acid-base balance, characteristic of the mucous membranes of the genital organs. It is when it is violated that the protection weakens, and thrush and other fungal diseases appear.
- sodium laureth sulfate - chemical compound, contained in the gel in small quantities, only to form a good foam.
- glycyrrhizic acid - it is obtained from licorice root extract. It eliminates redness and irritation of the skin and activates the process of tissue regeneration, in other words, heals damaged areas.
It is worth adding that the product does not contain perfumed fragrances or dyes. Prevention of unpleasant odors is ensured by the elimination of pathogenic microorganisms.
Instructions for use
For preventive purposes, the gel is used daily, without interruptions during pregnancy and menstruation. The product is recommended for use after swimming in a pool or natural body of water. To prevent sexually transmitted infections, they should treat the intimate area before and after sexual intercourse.
If Epigen gel is used not just for intimate hygiene, but for treatment, the instructions prescribe using it more often, up to 5 times a day, treating the genitals with it. This is especially important to do before using Epigen spray. This drug is a liquid in an aerosol bottle that is used intravaginally - sprayed inside the vagina (and inside the urinary canal in men). The spray contains a larger amount of medicinal substances intended for the treatment of chronic fungal diseases of the genital organs with frequent relapses.
For treatment and prevention, a small amount of gel is applied to the genitals and foamed, and then washed off with warm water. Epigen is suitable for both women and men.
Reviews about the drug
Epigen intimate hygiene gel has collected a lot of positive reviews, the number of which is increasing every day. The product, according to consumers, really relieves the symptoms characteristic of thrush. Permanent use The gel provides many people with the onset of complete remission in chronic diseases provoked by fungi and other pathogenic microorganisms.
Almost everyone who has used it notes the very economical use of the product and its pleasant thick consistency. One click on the dispenser is enough to get the amount of gel needed for washing. Allergic reactions due to intolerance to individual components of the drug, according to reviews, are rare.
What can replace the well-known but expensive gel?
Despite all the advantages of the product, many consumers are not satisfied with its high cost - about 700-800 rubles. However, those who, for financial reasons, do not want to buy Epigen-gel for intimate hygiene can purchase its analogues. Drugs similar in composition and medicinal action include:
Intimate problems put most people in uncomfortable position, and many, out of shame, do not even dare to go to the hospital in a timely manner and treat both themselves and their sexual partner. It is important to understand that no area related to health should cause inconvenience, and if the first symptoms appear, you should immediately consult a doctor. Depending on the source of the problem, a specialist can prescribe both complex, systemic treatment and local impact. The latter can be done using a very convenient method - using the intimate spray Epigen Intim.
Composition of Epigen Intim spray
The spray for treating the intimate area against pathogenic microorganisms is based on a substance obtained from licorice root extract - glycyrrhizic acid, and in an activated form, which significantly enhances its properties. It is this product that has a broad multifactorial effect, including the fight against viruses, anti-inflammatory and immunostimulating effects. The work of this acid is based on its ability to improve the intensity of interferon synthesis, as well as the activity of lymphocytes and their levels. In the spray, the concentration of the active ingredient is 0.1%.
The composition also includes additional auxiliary ingredients: fumaric, ascorbic, maleic, folic acids, propylene glycol, purified water and Tween (one of the types of emulsifiers).
Pharmacological action of intimate spray
An intimate spray is used as an antiviral agent that stimulates immune defense, intended for topical use. In theory and in practice, the active substance of the spray has powerful action against Varicella Zoster, cytomegalovirus and human papillomavirus. The acid disrupts the process of replication of viral elements at the earliest stages, further stimulating the local immunity of the treated area, which further enhances the antiviral activity. Both mutant and non-mutant strains that are resistant to other commonly used antiviral agents are sensitive to the spray.
It should be noted anti-inflammatory effect of the product - after application, the production of so-called inflammatory mediators slows down, cell regeneration is activated, which leads to maximum rapid recovery conditions of the mucous membrane. It should be noted that the spray is applied topically, and therefore systemic absorption is negligible.
What is it used for: indications for use
The intimate spray has a specific area of use and helps patients fight pathogenic microorganisms that have penetrated the genital mucosa. Thus, the indications for use of the drug are:
- therapy for papillomavirus, even with asymptomatic treatment and a highly oncogenic type;
- treatment of herpes simplex virus infection;
- as part of complex therapy for herpes zoster (varicella zoster), cytomegalovirus;
- preventing relapses of all of the viruses described above;
- preventive and therapeutic use for cervical pathologies provoked by the previously listed viruses;
- a state of decreased local level of immune defense, which occurred, among other things, due to nonspecific colpitis, vulvovaginitis, bacterial vaginosis, etc.;
- uncomfortable symptoms in the area of both female and male genital organs (including itching, increased dryness, burning).
Instructions for using intimate hygiene spray
The spray is a very convenient form to use, and there are usually no problems during the application of the medicinal composition. The injection can be made both externally and internally (meaning intravaginally or into the male urethra). The mechanism for carrying out the event is simple: the can must first be shaken well, placed in a vertical position at a distance of several centimeters from the treated area, and only after that can it be sprayed. If insertion is required, a special nozzle-tube is put on, which is inserted into the the desired cavity in a lying position. It is worth noting that after each procedure for internal administration of the drug, you must thoroughly wash the nozzle with soap and wipe it dry, otherwise self-infection may occur again. As for the duration of therapy and dosages, it all depends on the specific situation.
Use to treat herpes
The causative agent of genital herpes is a virus herpes simplex, existing in two types. This problem is usually transmitted sexually and has extremely unpleasant manifestations: redness, itching, burning, the formation of numerous rashes in the form of blisters, which gradually burst and form ulcers. The drug in question is very often prescribed for the treatment of this disease. According to the instructions, it must be applied to the mucous membrane of the genital organ 5 times within one day for two weeks, and additionally intravaginally (with the appropriate recommendation of a doctor). After the acute phase has passed, to prevent relapse, another course of maintenance therapy is carried out - for 10 days, 3 application procedures are performed per day, both externally and internally. The average recommended dose is 1-2 sprays, no more.
With papillomavirus infection
Genital human papillomavirus infection is one of the most commonly diagnosed sexually transmitted problems. The danger of this infection lies in the fact that it increases the risk of developing cervical cancer and other types of cancer of the anogenital area, and can also be the source of several types of malignant skin tumors. To treat such a dangerous disease, the spray is used as an element of an integrated approach:
- 3 times a day throughout the entire course of treatment of formations;
- after removal of formations - 5 times a day until complete healing, but not less than 10 days;
- To avoid repeated outbreaks in the near future, therapy is continued for another month, 3 procedures per day.
If there is a virus in the body, in order to prevent its progression, a spray is used before and after sexual intercourse, as well as after encountering negative factors (stress, ARVI, taking antibiotics, etc.).
How to use to treat thrush
Fungal infection of the genital organs occurs in both men and women; it has signs that are familiar to almost everyone - curdled discharge, itching, redness of the mucous membrane, etc. As part of the general treatment of the disease, the spray can be used as a local antipruritic, anti-inflammatory and immunity-boosting agent. In case of such a diagnosis, it is necessary to treat the affected area 3-4 times a day for a week. If necessary, the course is repeated after 10 days.
How to use for preventive purposes
The spray, based on a natural active ingredient, can also be used as a prophylactic agent to avoid the development or recurrence of the disease. Thus, the prevention of new exacerbations can be carried out according to a special scheme for individual pathogens, but in general, the use of the product as a preventive antiviral drug before and after sexual intercourse, and in the event of severe stress or other risk factors, is permitted. In this case, 1-2 sprays per procedure will be sufficient.
Use during pregnancy
Experimental studies have not shown the toxic effects of glycyrrhizic acid on the developing fetus, and therefore the instructions allow the use of this drug at any stage of pregnancy, but only with appropriate indications and a doctor’s permission. Taking into account the local effect, use during breastfeeding is not prohibited.
Contraindications
Considering the specific composition of the intimate spray, it has a limited number of contraindications. So, you will have to refuse its use only if you are individually intolerant to the components, but in other situations, if there are indications, you can safely use it.
Side effects
Usually the spray is very well tolerated by all patients, even with a long period of use. In isolated cases, patients with individual intolerance experienced actively developing allergic reactions at the very beginning of therapy, most of which had exclusively skin manifestations (redness, rash, discomfort).
Analogues of the drug
There is no complete analogue of the drug in question, which makes it popular even despite its rather high cost. There are products based on the same active ingredient, acid from licorice root extract: Glycyrrhizic acid in pure form, Glyciram and Epigen Labial. However, all of the listed drugs are presented in tablet form and have a slightly different range of uses, so they cannot be called substitutes. There are antiviral sprays with other active substance, for example, Panavir gel-spray Intim based on an extract from potato top shoots.
Epigem Intim is a frequently prescribed drug, and its effectiveness is manifested even in cases with the problem of conditional pathogenic microflora, which, due to a decrease in the level of immunity, was able to develop (for example, candidiasis, although there is no such disease in direct indications). The product is especially effective and useful as a local drug for complex therapy of viral diseases. It is especially worth noting that practically complete absence contraindications and negative reactions, but you should not use the product just like that if any discomfort arises - it is better to use it as prescribed by a doctor.
Epigen is an antiviral drug of plant origin. Used for treatment viral infection: herpes, HPV, cytomegalovirus.
Brief information about the drug
Epigen is a foreign-made drug.
Produced from licorice root.
The active ingredient is glycyrrhizic acid.
It acts on the virus indirectly: it stimulates the production of its own interferon, which kills the virus.
Attention : There are two forms of release: Epigen Intim spray and Epigen Intim gel.
The spray is a medicinal form.
And the gel is only a preventive form: for intimate hygiene.
Epigen intimate spray: instructions and differences
This is the main dosage form of the drug!
The concentration of the drug in the spray is higher than in the gel. Therefore the effect is better.
Epigen intimate spray - a can of medicine (see photo). There is a nozzle for introducing the drug into the vagina.
Epigen intimate spray with nozzle
Instructions for use for HPV
Shake the can. When pressing, keep it vertical!!!
Women: lie on your back, insert the nozzle into the vagina and inject the drug with 1-2 presses. Lie down for 5 minutes. Rinse the nozzle. Repeat 4-5 times a day. Course – 7 days. Usually 4-5 courses are carried out.
For men simpler: spray epigen spray on the affected areas and into the opening of the urethra 4-5 times a day. The course is also about 1 month.
Instructions for herpes
For genital herpes: spray outside and into the vagina 6 times a day for two weeks. After this - 3 times a day - for another 10 days.
For shingles (herpes): spray on the affected area 6 times a day – 7 days.
Side effects
Allergic reactions and irritation are rarely possible. In this case, you cannot use the drug.
Epigen analogues for the treatment of HPV
Isoprinosine (or groprinosin) tablets - .
Many are trying to find analogues cheaper than epigen. But antiviral drugs are all expensive, since their production is expensive. Russian drugs will be a little cheaper, since they are produced in Russia: this is Panavir. But Panavir does not have an aerosol form.
During pregnancy
Pregnant women use epigen Can . Thus, in his research Vishnevsky L.S. et al. successfully used the drug in a group of pregnant women.
A group of scientists from the Ott Research Institute of Obstetrics and Gynecology at the Russian...
Side effects from taking the drug
In isolated cases there were recorded allergic manifestations on surfaces treated with the drug, in particular contact dermatitis.
How to use epigen intimate?
The drug is used locally, externally. All diseased skin is treated with an aerosol. To do this, keep the can at a distance of four to five centimeters from the skin and press the button twice. To treat herpesvirus, sore spots should be treated up to six times a day for five days. If this duration of treatment is not enough, you can use the drug until the signs of herpes completely disappear. If herpetic rashes appear on the genitals, treatments are carried out in the same course.
If the patient suffers from a complex type of genital herpes with periodic returns, in addition to external application to the mucous membranes, it is necessary to insert it into the vagina twice or three times a day for six to ten days.
To prevent the return of the disease, it is necessary to treat the external mucous membranes and inject it into the vagina twice a day from the eighteenth to twentieth days of the cycle. To insert the product into the vagina, the package contains a special device.
Before use, the device should be cleaned with warm water and soap. After which the valve is removed from the bottle and a special valve is installed in its place. Next, a special valve must be inserted into the vagina ( the patient should lie on her back). There are three to four injections per valve. The patient should lie down for another five to ten minutes. All valves should be washed thoroughly after each use. After which they are hidden in an impenetrable bag, which is included in the kit.
In the case of shingles, the affected areas need to be treated up to six times a day until completely cleared.
In the case of papillomavirus, if the rash covers the genital mucosa, around the anus and around the genitals, treatments are carried out up to six times a day for five to seven days.
If the rash is located in the vagina, the drug is administered into the vagina three times a day for five days. Unremoved growths are removed surgical method, then you need to once again conduct a course of epigenome intim.
For the treatment of vaginosis and nonspecific colpitis, the drug is prescribed three or four times a day for seven to ten days. If the treatment does not give the expected result, you must take another course ten days later.
To prevent infectious diseases transmitted during copulation, epigen intimate should be used before and after copulation.
Representatives of the stronger sex should treat the penis with the product and also pour it into the urethra by pressing the spray valve once or twice. Before use, the bottle should be shaken well and not turned horizontally.
Additional Information
Do not wash before or after treatment.
This medicine can be combined with any other medications, the effect is enhanced when used together with drugs based on interferon, iodouridine and acyclovir.
Should not be used simultaneously with interferonogens.
Epigen labial– the main active component of this product is also licorice extract. This analogue of Epigen Intima is a drug for protecting liver cells; in addition, it suppresses the activity of viruses. The drug includes a component necessary for the restoration of cells and their membranes, regulation of metabolism in liver cells. Under the influence of epigene labialis is activated cleaning function liver, tissue fibrosis is prevented.
The drug is available in capsule form and is prescribed for hepatitis in acute and chronic form, degeneration of liver cells, liver damage from toxic substances, poisoning, psoriasis, eczema, neurodermatitis.
The drug is taken orally, but it can cause allergic reactions.
In the treatment of genital warts in the experiment participants, a combination of the drug Epigen Intim and treatment of the affected areas with liquid nitrogen was used. This treatment method was used because condylomas were located simultaneously on the mucous membranes and on the skin. Cryodestruction was carried out from two to five times, and treatment with epigen intim was carried out five to six times a day. The duration of therapy is from ten to fourteen days. After treatment, one man experienced a return of the disease, but it should be said that his rashes were very extensive.
The drug Epigen Intim is prescribed to men for treatment urethra. Apply this remedy convenient for both treatment and prevention viral diseases. The duration of prophylactic use is ten days. It is recommended to use this drug for men who have unprotected sex with an insufficiently tested partner. In such cases, the penis and urethral outlet should be treated before and after copulation. As a rule, treatments are combined with the use of other medications. Clearer treatment recommendations should be obtained from a consultation with an andrologist.
Also, to maintain hygiene, men can use a gel of the same name, created specifically for daily hygiene.
There isn't enough today effective treatment viral infections described above. Therefore, the main task is to prevent infection or maintain the virus in a latent state. This will prevent the transmission of the virus from mother to fetus during its birth. The difficulty of controlling the infection lies in the fact that pregnant women are usually prohibited from using almost all medications.
The effectiveness and safety of Epigen Intim preparations have been tested and proven by scientists from the best Russian research institutes.
The spray can be used throughout the entire period of gestation and lactation. This drug does not poison the fetus, and also does not pass into breast milk and is completely safe for the development of a newborn.
Epigen intimate is effective against papillomavirus, herpes simplex, cytomegaloviruses, suppresses their activity and allows them to be maintained in a dormant state, preventing exacerbation.
If the virus is actively developing, you can inject the drug directly into the vagina three times, one or two injections over the course of six to ten days.
For cleansing birth canal for infection, the drug is injected into the vagina. This procedure helps prevent infection of the newborn.
In such cases, the drug is prescribed in the thirty-seventh - thirty-eighth week of gestation in a course of five days, six procedures per day. The woman's vagina and vulva are treated.
To prevent the development of pathogenic microflora during pregnancy, you can use Epigen Intim gel. This remedy maintains the acidity of the environment and relieves inflammation.
Epigen (gel and spray) is a series of antiviral agents for external and local use.
The active ingredient of the gel is ammonium glycyrrhizinate, the spray is activated glycyrrhizinic acid.
Spray Epigen
Activated glycyrrhizic acid, which is obtained from licorice root, interrupts the replication of viruses at the most early stages, which prevents them from entering cells.
Epigen Intim has a complex effect:
- antiviral.
- antipruritic.
- regenerating.
- anti-inflammatory.
- immunostimulating.
Glycyrrhizic acid increases the number and activity of T-lymphocytes when applied topically, induces the formation of interferon, increases the concentration of immunoglobulins A and M, but reduces the concentration of IgG.
The anti-inflammatory activity of the drug is combined with a stimulating effect on humoral and cellular immunity factors. Significantly inhibits the release of kinins by cells connective tissue in the area of inflammation.
Gel Epigen
It has antiviral properties, which are realized through stimulating effects on cellular and humoral factors immune system.
Ammonium glycyrrhizinate significantly inhibits the release of kinins and the formation of prostaglandins by connective tissue cells in the pathological focus of inflammation. The regenerating effects are based on this pharmaceutical drug, manifested in improved repair of the skin and mucous membranes.
Epigen gel for intimate hygiene perfectly relieves itching and eliminates all the causes of its occurrence, helping to strengthen local immunity and increase the number of beneficial lactobacilli.
What does Epigen help with? According to the instructions, the drug is prescribed in the following cases:
- comprehensive prevention gynecological diseases viral etiology, sexually transmitted diseases;
- infectious diseases caused by the human papillomavirus;
- erosions and other pathologies of the cervix;
- treatment and prevention of genital warts;
- as part of complex therapy in the treatment of herpes simplex virus infections types 1 and 2;
- itching, burning, dryness and other unpleasant sensations in the genital area;
- bacterial vaginosis;
- herpes zoster and infection with the Varicella Zoster virus;
- nonspecific vulvovaginitis;
- nosological units in which etiological factor cytomegalovirus appears;
- insufficiency of ovarian function.
Instructions for use of Epigen gel and spray, dosage
Gel
Used for intimate hygiene, not with therapeutic purpose. It is necessary to apply a certain amount externally to the genitals, lather and rinse thoroughly with warm running water. Natural components in the Epigen gel base allow you to repeat hygiene procedures several times a day.
The gel can also be used for prevention against thrush, since glycyrrhizic acid normalizes the acidity of intimate areas, cleanses skin and supports natural microflora mucous membranes of the genital organs.
Daily use of Epigen gel for intimate hygiene helps prevent damage to fungal cultures and avoid the very unpleasant discomfort associated with the problem of thrush.
Instructions for Epigen spray Intimacy
Shake the container before use and keep it in an upright position when using it.
For external use, the drug is applied to the entire affected surface from a distance of 4-5 cm by repeatedly pressing the spray valve.
For intravaginal use of Epigen Intim, a special nozzle is included. Before use, wash the nozzle with running water and soap, remove the valve from the spray bottle and put on the valve of the nozzle.
Then the nozzle is inserted into the vagina with the patient in a “lying down” position. The drug is injected by pressing the nozzle valve 3-4 times. After use, you must remain in the “lying” position for 5-10 minutes. The nozzle is washed with running water and soap and stored in the supplied plastic packaging.
In addition to external application of the spray, men need to inject the medication into the external opening of the urethra.
Standard dosages and time of use according to instructions:
- For herpesvirus infection type 1, herpes zoster, the drug is recommended to be used 6 times a day, on the affected area, for 5 days or until the symptoms of the disease completely disappear.
- For type 2 herpesvirus infection (genital herpes), CMV infection is recommended to be used externally and intravaginally 5 times a day for 14 days, after stopping the relapse - externally and intravaginally 3 times a day for 10 days.
- When treating severe forms and often recurrent forms of genital herpes, in addition to treating the external genitalia, the drug is administered vaginally 2-3 times a day for 6-10 days.
- In order to prevent relapses, the drug is used externally and intravaginally from 18-20 days menstrual cycle 2 times a day (morning and evening).
- For papillomavirus infection when papillomas are localized on the genitals, around the genitals and in the perianal area, Epigen Intim is applied 6 times a day for 5-7 days.
- When papillomas are localized in the vagina, apply intravaginally 3 times a day for 5 days. The remaining pointed and papillary formations are removed using physical or chemical destruction, after which a second course of treatment of the epithelial areas with glycyrrhizic acid is carried out.
- To prevent the progression of human papillomavirus infection, it is recommended to use it before and after sexual intercourse, as well as in the event of provoking factors, 3 times a day intravaginally and externally during the entire period of exposure to provoking factors.
- At bacterial vaginosis, nonspecific vulvovaginitis and vulvovaginal candidiasis, the drug is recommended to be used intravaginally 3-4 times a day for 7-10 days. If necessary, repeat the course of treatment after 10 days. If provoking factors occur, 3 times a day intravaginally and externally during the entire period of exposure to provoking factors.
- For symptoms of discomfort in the genital area, accompanied by itching, burning and dry mucous membranes, 2 times a day (morning and evening) for 2–3 weeks. To prevent discomfort, use regularly after sexual intercourse.
To prevent sexually transmitted infections, Epigen Intim spray is used before and after sexual intercourse. According to the instructions, for men, in addition to external application, the drug is injected into the external opening of the urethra with 1-2 presses of the spray valve.
Side effects
The instructions warn about the possibility of developing the following side effects when prescribing Epigen:
- Rarely - local allergic reactions (including contact dermatitis).
Contraindications
Epigen is contraindicated in the following cases:
- hypersensitivity to the components included in the drug.
Approved for use during the entire period of pregnancy and lactation.
Overdose
Currently, no cases of overdose with Epigen products have been reported.
Drug interactions
At simultaneous use glycyrrhizic acid with other antiviral drugs(acyclovir, iodouridine, interferon) synergism is noted antiviral action.
No clinically significant drug interactions between Epigen Intim and the main groups of drugs used in combination therapy for viral diseases (analgesics, NSAIDs, antibiotics) have been identified.
Epigen analogues, price in pharmacies
If necessary, you can replace Epigen spray with an analogue of the active substance - these are the following drugs:
- glycyram,
- Glycyrrhizic acid,
- Epigen labial.
When choosing analogues, it is important to understand that the instructions for use of Epigen, price and reviews of the drugs similar action do not apply. It is important to consult a doctor and not change the drug yourself.
Price in Russian pharmacies: Epigen intimate spray 0.1% 15 ml - from 972 to 1184 rubles, intimate spray 0.1% 60 ml - from 1760 rubles, intimate gel 250 ml - from 810 to 983 rubles, according to 683 pharmacies.
Shelf life of the spray is 36 months, subject to standard conditions storage and temperatures up to 30°C. Sale in pharmacies without a prescription.
5 reviews for “Epigen”
Epigen spray defeated thrush, which I had been suffering from for 10 years. The course was 10 days in the morning and evening, 2 “sprays” in the vagina. Lie down for 10 minutes in the morning, and naturally overnight in the evening.
It helped for the first three days, then the effect of the drug subsided. It's sad that such a result for such money. I bought it, however, not on the recommendation of a doctor, but a friend recommended it as a remedy for thrush and a good immunomodulator.
This Epigen spray was prescribed to me during pregnancy during thrush as a complex treatment. The effect is good, but I can’t say that it is 100% effective from this particular spray
I bought this spray, but then the gynecologist said that it was recommended for herpes. And if there is no such problem, you shouldn’t use it.
I will share my experience. I had vaginosis - the doctor prescribed Epigen. I used it and it was great, the itching and all the other “delights” went away, but a month passed and everything came back. Everything started again! Epigen in the trash. I bought Multigin Actigel and I immediately want to say girls, if you want to get rid of the problem, and not cover it up for a while, then take Multigin right away. Six months have passed, I feel great, there are no symptoms of vaginosis or discomfort!)
Epigen - instructions for use, reviews, analogs and release forms (spray 0.1% Intimate, cream or gel 0.1% Labial) of a drug for the treatment of simple and genital herpes, thrush or candidiasis in adults, children and pregnancy. Compound
In this article you can find instructions for use medicinal product Epigenes. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Epigen in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications were observed and side effects, perhaps not stated by the manufacturer in the annotation. Analogues of Epigen in the presence of existing structural analogues. Use for the treatment of simple and genital herpes, thrush or candidiasis in adult men and women, children, as well as during pregnancy and lactation. Composition of the drug.
Epigenes- antiviral agent for external and local use. Glycyrrhizic acid is active against DNA and RNA viruses, including various strains of Herpes simplex, Varicella zoster, human papillomavirus, and cytomegalovirus. The antiviral effect is apparently associated with the induction of interferon formation. Interrupts the replication of viruses in the early stages, causes the virion to exit the capsid, thereby preventing its penetration into cells. This is due to selective dose-dependent inhibition of phosphorylating kinase P. It interacts with the structures of the virus, changing various phases of the viral cycle, which is accompanied by irreversible inactivation of viral particles (located in free state outside cells), blocking the penetration of active viral particles through the cell membrane into the cell, as well as disrupting the ability of viruses to synthesize new structural components.
Inhibits viruses in concentrations that are non-toxic to normally functioning cells.
Virus strains resistant to acyclovir and iodouridine are highly sensitive to glycyrrhizic acid.
It also has an anti-inflammatory, analgesic and tissue regeneration-improving effect both in early manifestations of viral infection and in ulcerative forms.
Compound
Activated glycyrrhizic acid + excipients.
Pharmacokinetics
When applied externally and locally, activated glycyrrhizic acid accumulates in the lesions. Systemic absorption occurs extremely slowly, so biological fluids activated glycyrrhizic acid is practically undetectable.
Indications
- treatment of genital infections caused by the Herpes simplex virus type 2 (both in acute primary and recurrent course);
- treatment of skin infections caused by the Varicella zoster virus (as part of combination therapy);
- treatment of skin and mucous membrane infections caused by the human papillomavirus;
- treatment of nonspecific vaginitis, colpitis;
- prevention of common sexually transmitted viral infections;
- treatment and prevention of lesions of the lips, mucous membranes and skin in the mouth and nose area by the Herpes simplex virus (including those accompanied by dryness, ulceration, cracks).
Release forms
Spray for local and external use 0.1% (Epigen Intim or intimate spray).
Cream for local and external use 0.1% (Epigen Labial, sometimes mistakenly called gel).
Others dosage forms, be it an ointment, soap or aerosol, did not exist at the time the drug was described in the reference book.
Instructions for use and method of use
Intravaginal, external and intraurethral. The container must be shaken before use and kept in an upright position when using.
For external use, the drug is applied to the entire affected surface from a distance of 4-5 cm by 1-2 valve presses, which is the optimal therapeutic dose.
For intravaginal use of the drug, a special nozzle is included. It is a hollow tube 7 cm long, at one end of which there is a sprayer, and at the other end there is a valve. Remove the valve from the spray bottle and put on the nozzle valve. The nozzle is then inserted into the vagina with the patient lying on her back.
The drug is injected intravaginally by 1-2 presses of the nozzle, which is the optimal therapeutic dose.
After application, you must remain in a lying position for 5-10 minutes. When used by men, in addition to external application, the drug is injected into the external opening of the urethra with 1-2 presses of the spray valve.
For papillomavirus infection:
- before removal of condylomas - 3 times a day for the entire period of etiotropic therapy;
- against the background of destruction - 5 times a day for 10 days or more until healing;
- to prevent immediate relapses - 3 times a day for 1 month.
To prevent the progression of human papillomavirus infection: before and after sexual intercourse, as well as in the event of provoking factors - stress, fatigue, ARVI, microflora disturbance, taking antibiotics, cytostatics - 3 times a day intravaginally and externally for the entire period of exposure to provoking factors.
For skin infections caused by the herpes simplex virus (including herpes zoster): 6 times a day on the affected area for 5 days. With persistent flow infectious process the treatment period is extended until the symptoms of the disease completely disappear.
For genital herpes and cytomegalovirus infection: 5 times a day for 14 days externally and intravaginally, after stopping the relapse - externally and intravaginally 3 times a day for 10 days.
For nonspecific colpitis, bacterial vaginosis and vulvovaginal candidiasis: intravaginally 3-4 times a day for 7-10 days. If necessary, the course of treatment is repeated after 10 days. If provoking factors occur - ARVI, take antibiotics, cytostatics - 3 times a day intravaginally and externally for the entire period of exposure to provoking factors.
In cases of discomfort in the genital area, accompanied by itching, burning and dryness, incl. for insufficiency of ovarian function and after sexual intercourse: 2 times a day (morning and evening) for 2-3 weeks. To prevent discomfort, use regularly after sexual intercourse.
As a preventative antiviral agent The drug is recommended for use before and after sexual intercourse.
Apply the cream in a thin layer without rubbing onto the affected skin and mucous membrane 3-5 times a day for 3 days. If necessary, the course of treatment is continued until the symptoms of the disease completely disappear.
Side effect
Contraindications
- hypersensitivity to glycyrrhizic acid.
Use during pregnancy and breastfeeding
Use during pregnancy and lactation is possible according to absolute indications.
Experimental studies have not established the embryotoxic and teratogenic effects of glycyrrhizic acid.
Use in children
There is insufficient clinical data to support the use of Epigen in this age group.
special instructions
When treating skin infections caused by the Varicella zoster virus, external use of glycyrrhizic acid should be combined with oral administration of specific antiviral drugs.
If signs of irritation of the skin or mucous membranes appear, treatment should be discontinued.
Drug interactions
With the simultaneous use of glycyrrhizic acid with other antiviral drugs (acyclovir, iodouridine, interferon), potentiation of the antiviral effect is observed.
During the course of treatment of a viral infection with the drug, the use of interferonogens is not recommended.
Analogues of the drug Epigen
Structural analogues of the active substance:
Analogs for therapeutic effect (medicines for the treatment of herpes simplex):
- Alpizarin ointment;
- Amiksin;
- Anaferon;
- Anaferon for children;
- Antiherpes;
- Arbidol;
- Acyclovir;
- Valogard;
- Valtrex;
- Valtsikon;
- Vectavir;
- Virazol;
- Virdel;
- Virolex;
- Virosept;
- Vitagerpavac;
- Viferon;
- Galavit;
- Gevisosh;
- Gerpevir;
- Herpesin;
- Herpferon;
- Groprinosin;
- Devirs;
- Zovirax
- Isoprinosine;
- Kagocel;
- Kipferon;
- Lavomax;
- Lisavir;
- Lycopid;
- Lomagerpan;
- Lorinden C;
- Sodium nucleinate;
- Neovir;
- Panavir;
- Supraviran;
- Famvir;
- Famciclovir;
- Ferrovir;
- Cyclovax;
- Cyclovir;
- Citivir;
- Ergoferon.
Epigen spray - description and analogues
"Epigen spray" refers to antiviral drugs. Use – local, external. The main component of the drug is glycyrrhizic acid, which acts against RNA and DNA containing viruses, including various types of virus and cytomegaloviruses.
At the same time, during the anti-inflammatory effect, interferon is formed, which leads to the interruption of further reproduction and replication of viruses, especially in the early stages. The virion exits the capsid, as a result of which it no longer penetrates the cells. The drug also inhibits viruses in the maximum required quantities. The drug is not toxic and does not interfere with the normal functioning of cells.
In addition, it has analgesic, anti-inflammatory, and regeneration-improving effects. This effectiveness of the drug is observed both in the early stages of diseases and in chronic or ulcerative manifestations.
The simultaneous use of Epigen spray leads to potentiation of the antiviral effect.
During pregnancy and lactation, treatment with drugs containing glycyrrhizic acid is prescribed only for medical indications and is carried out under medical supervision. The potential risk of the drug has not been fully established.
Indications for use
- A prophylactic against infectious diseases that can be sexually transmitted;
- Nonspecific vaginitis;
- In the treatment of infectious diseases caused by groups of Herpes simplex viruses of the second type;
- Colpitis;
- Infectious skin diseases, in particular those caused by the Varicella zoster virus;
- Diseases caused by the human papillomavirus.
Possible side effects
If you are intolerant or sensitive to glycyrrhizic acid, allergic reactions are possible.
Contraindications
In case of intolerance to the main components of the drug or their derivatives.
The drug is often prescribed for the treatment of viral diseases as part of complex therapeutic treatment.
Analogues of "Epigen spray"
"Epigen intimate"
Completely similar to Epigen spray, the main active ingredient is glycyrrhizic acid, has similar medicinal actions, has the same side effects and contraindications.
"Glycyram"
Contains similar active ingredients- licorice root extract (glycyrrhizic acid) and ammonium glycyrrhizinate.
It is an anti-inflammatory agent for viral diseases of the genital organs, skin, and mucous membranes.
Release form: tablets. It also has laxative properties that relieve spasms, while simultaneously activating the adrenal cortex. In addition to the above diseases, it is prescribed for the treatment of respiratory diseases with increased secretion, eczema, and allergic dermatitis. It is also a preventative against the occurrence of withdrawal syndrome during hormonal therapy.
Contraindications
In case of individual intolerance or manifestations allergic reactions for glycyrrhizic acid. In such cases, treatment with the drug is canceled.
Prescribed with caution during pregnancy and lactation period.
The course of treatment with the drug depends on the severity of the disease, and can last from two to three weeks to six months.
"Epigen labial"
- A medicine that also contains the active substance glycyrrhizic acid (licorice extract).
- It has antiviral, regenerating, analgesic properties. Additionally, it contains an epigene component, which has a suppressive effect on viruses.
- Release form: capsules. Also prescribed in the treatment of psoriasis, neurodermatitis, eczema.
- Contraindicated in case of intolerance to glycyrrhizic acid.
Proper and comprehensive care of the intimate parts of the body is the key to general health body. On sale there are both simply cleansing products for intimate hygiene, and products intended to treat certain diseases and increase local immunity. Intimate hygiene gel “Epigen Intim” belongs to the second type of product.
Description and properties
This product is one of the most famous and best-selling. It does not contain any harmful substances, but only useful and natural ingredients. Using this product, you can not only thoroughly clean intimate areas, but also eliminate unpleasant odors, enhance tissue cell regeneration and reduce the number of harmful bacteria on mucous membranes.
In addition, this gel for intimate hygiene perfectly relieves itching and eliminates all the causes of its occurrence - various bacteria and viruses. Active substances This product helps strengthen local immunity and increases the number of beneficial lactobacilli. They strengthen the body’s defense against harmful microorganisms and are also responsible for normal work iron
Gel for intimate hygiene" Epigen Intim“actively relieves irritation and itching, the appearance of which is not associated with germs and viruses, but is a consequence of using unsuitable personal hygiene products and wearing synthetic underwear.
This particular product is ideal for use by pregnant and lactating women, those who suffer from chronic candidiasis, frequent inflammation and irritation in the intimate area. Can also be used during menstrual bleeding.
Gynecologists who recommend this product to their patients say with confidence that it really effectively cleanses intimate areas, strengthens their local immunity and actively fights any pathogenic microorganisms. This product is not just suitable for daily use, but can also be used more than three times a day. Such high efficiency of this cleansing gel is due to its composition.
Compound
This intimate cleansing gel mainly contains only natural ingredients:
- Lactic acid. It is she who is responsible for the normal protection of intimate areas from harmful bacteria. When the body produces this substance in insufficient quantities, various fungal diseases appear.
- Glycyrrhizic acid is responsible for eliminating itching, burning and redness of the skin. Has an immunostimulating effect. It is extracted from the root of a well-known plant - licorice. Has a powerful regenerating effect.
- Phytosminosins have good antimicrobial and anti-inflammatory effects. This component is an extract from yeast cells.
- A component such as glycerin is responsible for effective moisturizing and nourishing the skin..
The composition also contains a chemical ingredient such as sodium laureate sulfate. It is responsible for the foaming of the gel and the ease of rinsing it off. In addition, the cleansing gel contains no fragrances, preservatives or parabens. Effective elimination unpleasant odor and protection against its reappearance is achieved by destroying harmful microorganisms, as well as restoring normal microflora intimate areas.
Scope of application
You can use Epigen Intim gel not only for the most thorough and safe cleansing of intimate areas, but also in the following cases:
- In the presence of viral herpes diseases, as well as in the presence of any infections caused by papillomavirus.
- In case of relapse of any infectious diseases.
- For elimination unpleasant symptoms such as itching, burning and redness.
- To increase local immunity, normalize microflora.
- To protect against repeated damage to intimate areas by pathogenic organisms.
If the use of this product is not prescribed by a specialist, then it must be used strictly in accordance with the instructions. To clarify the diagnosis, it is necessary to visit a gynecologist or venereologist.
How to use
The product must be used according to its instructions, since depending on your goals, the number of uses per day of this product may differ from each other. In all cases, a small amount of gel is applied to intimate areas, foamed, and then thoroughly rinsed with running water.
The instructions say that as a daily cleanser, this gel should be used twice a day: in the morning after waking up and in the evening before going to bed. During menstrual bleeding it is necessary to increase the amount of its use up to 4 times. Gel "Epigen Intim" can be used immediately after intimacy, in this case both women and men can use it.
If the product is used not just as a cleansing product, but also as a preventive gel, then it must be used at least 5 times a day. The exact number of uses depends on the specific disease being treated. So, during treatment herpetic infection intimate gel is used 5 times a day for at least 6 days. Then the number of its uses is reduced to twice a day. For herpes zoster and papillovirus infection, the gel is used six times a day for 5 or 7 days.
It is worth noting that when treating, and not just preventing any diseases, it is necessary to use this intimate gel with a spray from the same series. Thus, the effectiveness of treatment increases and the risk of recurrence of the disease is significantly reduced.
Analogs
Gel for intimate hygiene" Epigen Intim“It has not only high efficiency and safety, but also high cost. The following products can be identified as its main analogues:
- » Lactacyd". Excellent cleansing and prophylactic, perfectly eliminates unpleasant odor, normalizes the microflora of the intimate area, eliminates irritation, itching and burning. Foams well, rinses off easily, has virtually no aroma.
- Soap for intimate hygiene" Vagilak". Despite the fact that this product is cheaper, its effectiveness in preventing diseases is higher than that of the gel." Epigen Intim". It is economically used, cleans intimate areas well and carefully, removes all unpleasant odors and prevents them from appearing again.
- » Vagicil“- this product is intended not only for thorough cleansing of intimate areas, but also for effective treatment fungal infections, in particular thrush.
- » SebaMed“Ideal for very sensitive skin and recommended for pregnant and breastfeeding women. Cleans perfectly, destroys almost all types of pathogenic microorganisms, and leaves behind a feeling of cleanliness and freshness for a long time.
- » Sesderma“is a full analogue of the gel” Epigen Intim". Eliminates pathogenic fungi, cleanses the skin, eliminates unpleasant aroma, relieves itching, redness and irritation of the skin, and also normalizes the microflora of the intimate area.
The drug epigen spray is an antiviral and immunostimulating agent, which contains glycyrrhizonic acid. It is obtained from licorice root, i.e. 100% plant based.
The medicine has an active complex effect, namely:
- immunostimulating:
- antiviral;
- regenerating;
- anti-inflammatory;
- antipruritic.
Thanks to glycyrrhizated acid, interferons are formed (these are the main substances for providing an antiviral effect). When exposed to it, the reproduction of viruses is interrupted.
Glycyrrhizic acid
During laboratory diagnostics It was found that the strain of the virus, most often resistant to acyclovir substances, has great sensitivity to glycyrrhizic acid.
Description
Available in the form of a spray, simple and intimate (that’s what it’s called, Epigen Intimate spray). In addition to acids, the composition also contains some auxiliary components and water.
The medicinal solution is released Brown with a characteristic pungent odor.
Active against the following viruses:
- Papilloma;
- Cytomegaly;
Shingles
Instructions for use
According to the instructions, Epigen spray can only be prescribed by a specialist after a full examination.
- For condylomas, the formations are treated twice a day.
- The drug has also proven itself against herpes. When affected by a simple herpes virus, as well as during development, the doctor asks to treat the skin externally or vaginally. The course of therapy is 2 weeks, wounds need to be treated at least 4 times a day. When symptoms decrease, doctors advise using the product for about another week, 2 times a day. This way you can consolidate the results obtained and prevent relapse.
- When cells are destroyed, for example, if the body is infected with HPV, doctors prescribe treatment of the skin and mucous membranes with medicine, about 4 times a day. Course - 2 weeks. Therapy must be continued until complete recovery; if necessary and with the permission of the doctor, the course may be slightly increased.
- To avoid relapse, you need to treat the skin with a spray at least 3 times per knock, for a course of about a month.
- Epigen spray for thrush is used to prevent candidiasis, 2 times a day, course - 3 weeks.
Interaction
Specific interactions with drugs from other groups have not yet been identified.
In combination with the drug, antibiotics, antiseptics, and analgesics are used (since the spray does not anesthetize).
Precautions and contraindications
The product should not be used in case of individual sensitivity to any component.
Epigen spray does not pose any danger during pregnancy and lactation. This is due to the fact that the drug does not pass into breast milk and has no effect on the embryo.
Rules
- Be sure to shake the bottle before spraying.
- The bottle itself must be held vertically.
- You need to spray the product from a distance of 6 cm, pressing the valve not once, but at least twice.
- If you need to use the spray intravaginally, you need to take a special nozzle, which is in the box. You need to lie on your back, insert the nozzle into the vagina and press the valve 1-2 times. Then you need to stay awake for 10 minutes for the product to take full effect.
Analogs
Epigen spray has two main analogues:
- Lactacid. Recommended for use in case of irritation, itching, dryness as an intimate hygiene product. The drug eliminates unpleasant odor and does not irritate the skin (and therefore can be used even if it is sensitive). Doctors recommend this remedy for daily use.
- Glitsam or Glitsir. The product has the same main component, licorice root extract.
Price
The spray costs about 950 rubles. The price may vary depending on the selling pharmacy, but not significantly.