Pentalgin. Composition, release form, analogues. Instructions for use. Indications, contraindications, side effects. Green tablets without a prescription Pentalgin: instructions, price and reviews

"Pentalgin", what does this anti-inflammatory help with? medicine? A drug with antispasmodic, analgesic and antipyretic activity is Pentalgin. The instructions for use of the medication indicate that it significantly helps with feverish and painful conditions, and relieves fever during colds.

Varieties and composition

1. Drotaverine hydrochloride.
2. Naproxen.
3. Caffeine.
4. Pheniramine maleate.

Green-colored tablets are coated. Auxiliary components are: cellulose, starch, talc, citric acid, povidone and other substances.

The tablets are packaged in contour cell shells of 2, 6, 10 and 12 pieces in a cardboard box, the drug is accompanied by instructions for use with a detailed description.

Pharmacological properties

The medicine "Pentalgin", which helps for many indications, has 5 active components that determine its effect.

The non-steroidal anti-inflammatory substance Naproxen provides antipyretic, analgesic and anti-inflammatory effects. This is achieved due to the ability of the component to inhibit the reproduction of prostaglandins.

Drotaverine hydrochloride has an antispasmodic effect, normalizes the functioning of the smooth muscles of the biliary tract, gastrointestinal, genitourinary and vascular systems.

The presence of paracetamol as an active element allows the medicine to have an analgesic and antipyretic effect. This occurs by blocking cyclooxygenase, an enzyme that promotes the formation inflammatory process, as well as inhibition of pain centers and thermoregulation.

Caffeine tones blood circulation, dilates blood vessels in the brain, heart and other organs. The substance invigorates and eliminates drowsiness. Caffeine shows psychostimulating properties and enhances the effect of other active ingredients.

Due to the inclusion of pheniramine in the composition, antispasmodic and sedative properties are slightly manifested, and the analgesic effect of naproxen and paracetamol increases.

The drug "Pentalgin": what helps

Indications for use include the following diseases and states:

• algodismenorrhea;
• toothache or headache;
• migraine;
• neuralgia;
• painful periods;
• high body temperature;
• muscle and joint pain;
• fever during a cold.

What else do Pentalgin tablets help with? The drug is used for pain and spasms during pathologies such as:

• renal colic;
• radiculitis;
• postcholecystectomy syndrome;
• cholecystitis;
• cholelithiasis;
• after operations and injuries.

• Pentalgin tablets: instructions for use

  You need to drink 1 piece after meals. The maximum daily amount should not exceed 4 tablets. The duration of treatment does not depend on symptoms. To reduce fever without medical prescription, tablets are taken for 3 days, to counteract pain - for 5 days.

  If there is no improvement, you should consult a specialist. The dose indicated in the instructions for use for the drug "Pentalgin" cannot be exceeded. In case of overdose, the following are observed: loss of appetite, tachycardia, nausea or vomiting, pallor, arrhythmia, anxiety, tremor, seizures, etc. Symptomatic treatment is necessary.

Contraindications

The instructions for use prohibit taking the medicine "Pentalgin" when:

• individual non-acceptance of the constituent components;
• severe kidney failure;
• hyperkalemia;
• ventricular extrasystole;
• high blood pressure;
• ulcers and erosions of the stomach and intestines;
• aspirin asthma or triad;
• sinus polyps;
• paroxysmal tachycardia;
• myocardial infarction and other complex diseases of the heart and blood vessels;
• after coronary artery bypass surgery;
• internal bleeding;
• inhibition of bone marrow hematopoiesis.

You should not use the medicine "Pentalgin" during pregnancy, children under adulthood, or during lactation. Caution during therapy is necessary for elderly people, as well as those suffering from diabetes, kidney and liver failure. initial stages, arterial pathologies, seizures, hepatitis, stomach ulcers in the past.

Side effects

The drug "Pentalgin", reviews and instructions for use confirm this, can provoke unpleasant effects and disorders in the functioning of various body systems. As a result, the following may be observed: side effects:

• allergies;
• itching, agitation, nausea or vomiting;
• kidney dysfunction, skin rash;
• heartbeat failure, hearing impairment;
• hives, headache, constipation;
• leukopenia, tremor, angioedema;
• hypertension, anxiety, thrombocytopenia;
• dizziness, agranulocytosis, arrhythmia;
• anemia, sleep disorders, methemoglobinemia.

Price and analogues

"Pentalgin" can be replaced by such drugs as: "", "Ibuprofen", "", "Paracetamol", "Amizon". You can buy tablets for 65 – 170 rubles. The medicine is available without a prescription.

Conditions of release and storage

Pentalgin tablets are sold in pharmacies without a doctor's prescription. The shelf life of the drug is 3 years from the production date; after this period, the drug is not recommended for use.

Must be stored in a dry place, out of reach of children, at a temperature of no more than 25 degrees, avoiding direct contact sun rays on a blister.

Patient opinions

Most often, women praise Pentalgin tablets. Reviews talk about relief during painful periods. The medicine also helps, although only briefly, for toothache or headache. Doctors talk about the effectiveness of the remedy for unpleasant symptoms in the muscles. Their reviews warn that Pentalgin should not be taken long time to prevent, by relieving pain, the development of a complex disease.

Pentalgin contains the following active ingredients: paracetamol, caffeine, pheniramine. Naproxen is a non-steroidal drug that has analgesic, anti-inflammatory and antipyretic effects. Drotaverine acts on smooth muscles gastrointestinal tract, biliary tract and genitourinary system. Paracetamol has an analgesic and antipyretic effect. Caffeine tones the blood vessels of the brain, dilates the blood vessels of the heart, and helps eliminate drowsiness. Pheniramine exhibits a mild sedative and antispasmodic effect, enhances the analgesic effect of naproxen and.

"Pentalgin" is prescribed for pain syndrome caused by spasm of smooth muscles in chronic cholecystitis, cholelithiasis, and renal colic. The drug is used for colds accompanied by fever, pain syndrome of various origins ( headache, radiculitis, pain in muscles and joints, neuralgia, toothache). "Pentalgin" can be prescribed for cancer.

"Pentalgin" is taken orally, one tablet at a time. The daily amount of the drug should not exceed four. The duration of use depends on the symptoms. Pentalgin is taken as an anesthetic for up to five days, and as an antipyretic – for three days. If there is no improvement while taking the drug, you should consult a doctor to clarify the diagnosis.

The drug can be prescribed for postoperative and post-traumatic pain syndrome.

Contraindications to the use of Pentalgin

The drug is not prescribed for erosive and ulcerative lesions of the gastrointestinal tract in the acute stage, in combination bronchial asthma, nose and paranasal sinuses due to intolerance to aspirin or other non-steroidal drugs, with renal and liver failure severely, after aortocoronary, severe arterial hypertension, with gastrointestinal bleeding, liver failure, and adolescents under eighteen years of age, and during breastfeeding(lactation).

When side effects You must stop taking Pentalgin and consult a doctor.

Side effects of Pentalgin

According to reviews, Pentalgin is well tolerated. However, in some cases the following side effects may occur: urticaria, skin rash, itching, agitation, increased reflexes, anxiety, headache, decreased concentration, sleep disturbance, dizziness. Impaired kidney and liver function, nausea, vomiting, constipation, abdominal pain, hearing loss, arrhythmia, increased blood pressure, heartbeat. In details

Pentalgin is a combined medication that has anti-inflammatory, antipyretic, antispasmodic, and analgesic effects. Thanks to the presence of several active components, it has sufficient wide range effects on the body.

Pentalgin is a highly effective remedy that helps eliminate not only moderate but also severe pain of various etiologies. It is a non-steroidal, non-narcotic drug, eliminates spasms, inflammatory foci, blocks receptors for increased histamine production, and has a psychostimulating effect. This article will tell you in detail about the composition of the product, who is allowed to use it and how it is taken.

Composition and effect of the medicine

The drug is produced in a tableted capsule-shaped convex form with beveled edges. On one side, the coated tablets bear the name in Latin letters, on the other side there is a risk. The color of the medication can be either light green or deep green. There are inclusions on the cut of the medicine white. Sold in cardboard packages.

One tablet contains:

1. Paracetamol.
2. Pheniramine maleate.
3. Naproxena.
4. Drotaverine hydrochloride.
5. Caffeine.

The medication Pentalgin Neo contains caffeine, codeine, and phenobarbital. Pentalgin N tablets contain naproxen instead of paracetamol, Pentalgin Nova contains codeine. Pentalgin P consists of analgin, paracetamol, caffeine, codeine, phenobarbital.

In addition to active ingredients, the drug contains Excipients, which do not affect the human condition. The drug includes:

• Magnesium stearate;
• indigo carmine;
• starch;
• cellulose;
• citric acid;
• talc;
• butylated hydroxytoluene;
• dye;
• hydroxypropylcellulose.

The components of the Pentalgin shell are as follows:

• povidone;
• talc;
• titanium dioxide;
• hypromellose;
• yellow dye;
• polysorbate.

Pentalgin can be purchased at any pharmacy. A doctor's prescription is not required to make a purchase. The shelf life of the drug is 24 months from the date of production. The medication is stored in a dry, dark place.

The broad effect of the drug is due to its unique composition:

When is it prescribed?

According to the instructions for use of the drug, it has anti-inflammatory, analgesic, antipyretic effects, therefore it is used for various ailments. So, what does this medication help with? It is often used to remove pain of various nature:

• articular;
• muscular;
• dental;
• head;
• inflammatory;
• antispasmodic.

The use of Pentalgin in the postoperative period is often recommended. It also helps relieve febrile state caused by a cold-related disease. During your appointment of this medicine you need to carefully study the instructions.

So, the drug is prescribed orally, 1 tablet 1 to 3 times a day. For severe pain attacks or migraines, you can take no more than 2 tablets at a time. The maximum daily dose should not exceed 4 tablets.

The duration of treatment is determined individually, based on the patient’s condition. If Pentalgin is used as an antipyretic, then it should not be taken for more than 3 days, an anesthetic - 5. If there is a need, then, on the recommendation of the attending physician, the period will be increased.

The drug is used in the following cases:

Contraindications and side effects

Despite such unique composition, high result with decreasing pain syndrome, Pentalgin also has contraindications for use. Due to availability large quantity restrictions, before taking it, it is recommended to first read the instructions. The medicine is contraindicated for use in the following conditions:

In addition to obvious contraindications, there are also conditions in which Pentalgin is dangerous to use. These include:

• circulatory disorders;
• a history of ulcerative lesions of the gastrointestinal tract;
• high blood sugar;
• age after 65 years;
• epilepsy.

During long-term use of Pentalgin, more than 3 days, patients may experience the following symptoms: side effects:

• the digestive tract may react to long-term use of Pentalgin with nausea, stomach pain, vomiting, loss of appetite, exacerbation of chronic diseases;
• the circulatory system reacts with a decrease in the number of leukocytes, platelets, and anemia;
• the nervous system reacts with tremor, dizziness, insomnia, increased blood pressure, and headache;
• the heart may react with arrhythmia, increased blood pressure, and tachycardia;
• the urinary system often reacts with the appearance of problems with the functioning of the kidneys and the occurrence of nephritis.

Also, the body of a person who takes Pentalgin for a long time reacts with tinnitus, and a decrease in visual acuity is observed. In addition, an allergic reaction may occur in the form of a rash, swelling, or anaphylactic shock.

If such phenomena occur, you can perform gastric lavage, drink Activated carbon. If after taking Pentalgin side effects persist for some time, you should stop taking it and consult your doctor.

Interactions with drugs and available analogues

To avoid deterioration of the patient’s well-being, the interaction of Pentalgin and other medications. For example, it is prohibited to drink it together with:

Part this drug contains substances that can reduce healing effect from medications used to treat diabetes mellitus. This must be taken into account even during periodic use of the drug. As a result, during correction of the condition with Pentalgin, it is important to simultaneously monitor blood sugar levels.

Today, pharmacies offer many medications that have a pronounced antispasmodic, antipyretic, and analgesic effect. Nevertheless, Pentalgin remains an undeniable leader. This is due to the fact that it combined composition makes it possible to solve many problems with the help of 1 tablet.

Pharmacies can offer the following as analogues:

1. Plivalgin.
2. Pentamialgin.
3. Pentalffen.

Replacing Pentalgin should be entrusted to the attending physician, since some analogues have serious contraindications that can cause a deterioration in the patient’s well-being.

Pentalgin, thanks to its composition, allows you to solve many problems. It is especially effective for headaches of various etiologies and intensity. However uncontrolled reception the drug may cause weight gain negative consequences. To avoid side effects, you must follow the instructions and recommendations of your doctor.

Analgesic medications are used to relieve pain of various origins. Their group includes Pentalgin; the drug is very effective in its analgesic properties, while taking it helps reduce inflammation and normalize temperature.

Composition and mechanism of action of Pentalgin

The drug is produced by Pharmstandard. Several medications are produced under the Pentalgin brand, differing in composition. Therefore, Pentalgin is sold in pharmacies with the prefix H, CN and plus. The main similarity of all these drugs is 5 components active substances and almost the same analgesic effect.

The active ingredients in Pentalgin may contain:

The multicomponent composition of Pentalgin provides maximum and quickly onset analgesic effect. The medicine can be taken for pain accompanied by fever, spasms and inflammation.

The different composition of Pentalgin allows you to choose the most effective subtype of the drug in each specific case.

Regular Pentalgin is available in the form of tablets, most often they are white, light green or green. There are inclusions on the fracture. The medicine is packaged in blisters of 4, 12 or 24 tablets.

Pentalgin is primarily a medicine for pain, so its use is advisable to eliminate:

• pain syndromes caused by osteochondrosis, radiculitis, neuralgia, joint pathologies, menstruation, dental problems;
• pain caused by spasm of smooth muscles during cholecystitis, urolithiasis and cholelithiasis;
• pain after injuries and operations;
• headaches.

Adults can take Pentalgin during treatment colds, occurring with rising temperatures.

Contraindications to Pentalgin

Before using Pentalgin, you need to study the instructions, since the list of contraindications to the use of the medicine is quite extensive. These include:

Failure to comply with contraindications increases the risk of adverse reactions, some of which can cause serious complications.

Possible adverse reactions

When taking Pentalgin, the occurrence of undesirable effects cannot be ruled out, most often these are:

Adverse reactions are mostly short-term in nature, that is, they disappear after discontinuation of the medication. But if the harm from the drug is greater than the benefit from it, then Pentalgin should be discontinued.

Regular Pentalgin is approved for use only from 18 years of age, but other subtypes of the drug can be used from 12 years of age.

Pregnant women should not take Pentalgin, as active ingredients cross the placental barrier. The ban on the use of the medicine also applies to the lactation period.

Features of use

How many Pentalgin tablets are required per day depends on the intensity of the pain. However, the manufacturer does not recommend taking more than 4 tablets per day, and the interval between doses should be at least 6 hours.

It is better to take a tablet after a meal; with food, the components of the medicine dissolve faster, and the risk of negative effects on the mucous membranes of the digestive system is reduced.

The duration of taking the medicine depends on the indications. As an anesthetic drug, Pentalgin is taken for no more than 5-7 days in a row; if the medication is used as an antipyretic, then the duration of its use is limited to three days.

Analogues of the drug

A package with a minimum number of tablets (4 pieces) costs an average of 45 rubles. If you are intolerant to certain components of the medication or if long-term use is necessary, analogues are selected, that is, drugs with an analgesic or antispasmodic effect.

In this medical article can be found medicine Pentalgin. The instructions for use will explain in what cases the tablets can be taken, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the forms of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Pentalgin, from which you can find out whether the medicine helped in the treatment of headaches, toothaches and fever in adults and children, for which it is also prescribed. The instructions list analogues of Pentalgin, prices of the drug in pharmacies, as well as its use during pregnancy. The conditions for over-the-counter and prescription dispensing are described, depending on the presence of components prohibited for general sale.

Anti-inflammatory and antispasmodic drug- Pentalgin. Instructions for use suggest taking tablets N, ICN, Plus, green without codeine for pain syndromes of various origins and colds accompanied by fever.

Release form and composition

The drug Pentalgin is available in the form of tablets (green over-the-counter) for oral administration, covered with a green protective film shell. On one side of the tablet there is an inscription in Latin letters (name of the drug). The tablets are packaged in contour cell membranes of 2, 6, 10 and 12 pieces in a cardboard box; instructions with a detailed description are attached to the drug.

They also produce tablets (H, ICN, Plus).

The tablets contain:

• Paracetamol + Naproxen + Caffeine + Drotaverine hydrochloride + Pheniramine maleate + excipients (green tablets, do not contain codeine and are sold without a prescription).
• Paracetamol + Metamizole sodium + Caffeine + Phenobarbital + Codeine phosphate + excipients (Pentalgin ICN).
• Metamizole sodium + Naproxen + Caffeine + Phenobarbital + Codeine (in phosphate form) + excipients (Pentalgin N).
• Paracetamol + Propyphenazone + Caffeine + Codeine phosphate + Phenobarbital + excipients (Pentalgin Plus).

pharmachologic effect

Pentalgin has analgesic, antispasmodic, anti-inflammatory, and antipyretic effects. The therapeutic effect of the drug is due to the properties of the active substances that are part of the drug:

Paracetamol has an antipyretic and analgesic effect, which is due to the blockade of COX in the central nervous system, as well as an inhibitory effect on the centers of pain and thermoregulation.

Caffeine, which is part of Pentalgin, causes expansion blood vessels skeletal muscles, heart and kidneys, tones the blood vessels of the brain and eliminates drowsiness. In addition, caffeine increases the permeability of histohematic barriers and increases bioavailability non-narcotic analgesics, which enhances the therapeutic effect of the drug.

Drotaverine has an effect on the smooth muscles of the gastrointestinal tract, genitourinary system, blood vessels and biliary tract.

Naproxen is pharmacological substance, which refers to non-steroidal anti-inflammatory drugs. This component has a pronounced antipyretic, anti-inflammatory and analgesic effect, which is associated with the normalization of prostaglandin synthesis.

Pheniramine has antispasmodic and mild sedative activity, and also enhances the analgesic effect of naproxen and paracetamol. Since some active ingredients penetrate the placental barrier, it is not advisable to use Pentalgin during pregnancy.

Indications for use

What does Pentalgin help with? The tablets have the following indications for use:

• colds with fever;
• various types of pain syndromes, for example, radiculitis, joint, muscle pain, during menstruation, neuralgia, algodismenorrhea;
• post-traumatic and postoperative pain, including with inflammatory phenomena;
• pain due to spasm of smooth muscles caused by chronic cholecystitis, cholelithiasis, renal colic, postcholecystectomy syndrome.

The drug is also used as a cure for toothache and migraines.

Instructions for use

Pentalgin tablets are intended for oral use. Adult patients are prescribed 1 tablet 1 to 3 times a day, depending on the indications and severity of pain. An adult can take no more than 4 tablets per day, and the interval between doses should be at least 6 hours.

The duration of the course of drug therapy is determined by the doctor depending on the indications, however, it is not recommended to take the tablets for more than 3 days, since in this case the risk of developing side effects and drug ulcers increases.

In some cases, treatment with the drug can be continued for up to 5 days with the permission of a doctor and under his supervision. If there is no therapeutic effect during treatment with Pentalgin tablets during the first day, the patient should contact a specialist to clarify the diagnosis and select another remedy.

Contraindications

• severe renal failure;
• severe arterial hypertension;
• children's and adolescence up to 18 years old;
• lactation period (breastfeeding);
• complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance acetylsalicylic acid or other NSAIDs (including in history);
• condition after coronary artery bypass surgery;
• frequent ventricular extrasystole;
• glaucoma;
• hyperkalemia;
• severe liver failure;
• erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);
• anemia, leukopenia;
• heavy organic diseases of cardio-vascular system(including acute myocardial infarction);
• inhibition of bone marrow hematopoiesis;
• hypersensitivity to the components of the drug;
• deficiency of glucose-6-phosphate dehydrogenase;
• pregnancy;
• alcohol intoxication;
• paroxysmal tachycardia;
• gastrointestinal bleeding.

Side effects

When treated with Pentalgin, undesirable effects may develop, for example, allergic reactions, disorders of the nervous, cardiovascular, digestive, genitourinary and hematopoietic systems, as well as sensory organs.

This may be accompanied by symptoms such as:

• anxiety, tremor;
• pain, erosive and ulcerative disorders of the gastrointestinal tract;
• increased blood pressure;
• abnormalities in kidney function;
• dizziness;
• methemoglobinemia, agitation;
• itching, skin rash;
• nausea, vomiting;
• constipation;
• irregular heartbeat, arrhythmia;
• thrombocytopenia, agranulocytosis;
• hearing loss;
• sleep problems;
• urticaria, angioedema;
• leukopenia, anemia;
• headache.

Children, pregnancy and breastfeeding

Contraindicated during pregnancy and lactation. Contraindicated for children under 18 years of age.

special instructions

Pentalgin should not be prescribed with other drugs based on paracetamol or containing NSAIDs, drugs to relieve symptoms of colds, flu and nasal congestion. Taking the drug for more than 5-7 days requires monitoring peripheral blood counts and liver function.

Paracetamol interferes with glucose test results and uric acid in blood plasma. If determination of 17-ketosteroids is required, Pentalgin is discontinued 48 hours before the test. It should be borne in mind that naproxen increases bleeding time.

The influence of caffeine in the composition of the drug can have both an exciting and inhibitory effect on the central nervous system. You should not drink alcohol during treatment. When driving vehicles caution should be exercised.

Drug interactions

Barbiturates received by the patient for a long time reduce the effectiveness of paracetamol. Diflunisal increases the plasma concentration of paracetamol by 50%, resulting in an increased risk of developing hepatotoxicity. Paracetamol reduces the effect of uricosuric drugs and enhances the effect of indirect anticoagulants.

Oral contraceptives, disulfiram, cimetidine, norfloxacin and ciprofloxacin reduce the metabolism of caffeine in the liver, thereby slowing down its elimination and increasing its concentration in the blood.

Drotaverine, which is part of Pentalgin, may weaken the antiparkinsonian effect of levodopa.

Hydantoin-derived anticonvulsants (especially phenytoin), barbiturates, and primidone may increase the metabolism and clearance of caffeine.

At simultaneous use other drugs that stimulate central nervous system, or drinking caffeine-containing drinks may cause excessive stimulation of the central nervous system.

Pheniramine - one of the active ingredients of Pentalgin - when interacting with ethanol, monoamine oxidase inhibitors, tranquilizers and sleeping pills enhances the inhibitory effect on the central nervous system.

Concomitant use of ethanol, tricyclic antidepressants, barbiturates or rifampicin increases the risk of liver toxicity, so such combinations should be avoided.

Another active substance Pentalgina - naproxen - can reduce the diuretic effect of furosemide, enhance the effect of indirect anticoagulants, increase the toxicity of methotrexate and sulfonamides, reduce the excretion of lithium and increase its concentration in the blood plasma.

Ethanol taken during treatment with Pentalgin increases the risk of developing acute pancreatitis. Inhibitors of microsomal oxidation (for example, cimetidine) reduce the likelihood of hepatotoxic effects of paracetamol.

Analogues of the drug Pentalgin

1. Paracetamol.
2. Ibuprofen.
3. Plivalgin.
4. Pentalgin Plus.
5. Pentalffen.
6. Pentamialgin.
7. Analgin.
8. Cardiomagnyl.
9. Sedalgin.
10. Amizon.
11. Pentalgin FS.

Vacation conditions and price

The average cost of Pentalgin (tablets No. 4) in Moscow is 90 rubles. Green tablets can be purchased at pharmacies without a prescription. Other forms are according to the recipe.

Tablets should be kept in a cool, dark place out of the reach of children. The expiration date is indicated on the packaging; do not use the drug after this period has expired.