Calcium-D3 Nycomed orange - official instructions for use. Chewable tablets Calcium D3 Nycomed (forte, mint): instructions, price and reviews

Combined drug Calcium-D3 Nycomed contains calcium and cholecalciferol ( vitamin D3). The drug regulates phosphorus-calcium metabolism and replenishes calcium deficiency in the body. Calcium is involved in the formation bone tissue, mineralization of teeth and bones, blood clotting processes, as well as the transmission of nerve impulses.
Taking the drug prevents excessive synthesis of parathyroid hormone, which increases bone resorption. Cholecalciferol regulates calcium absorption in gastrointestinal tract, as well as the distribution of calcium in the body.
After oral administration the active components of the drug are well absorbed in the gastrointestinal tract. Cholecalciferol is absorbed in the small intestine, calcium - in proximal part small intestine. The bioavailability of calcium is about 30%. Cholecalciferol is partially metabolized in the liver to form pharmacologically active metabolites. About 1% of calcium is found inside cells and in the extracellular space, the rest is concentrated in bone tissue. Calcium is part of complex compounds and proteins, about 50% is in ionized form. The active components of the drug are excreted by the intestines and kidneys, in addition, calcium is excreted through the sweat glands.

Indications for use

The drug is used for the prevention of osteoporosis, as well as the prevention and treatment of calcium and/or cholecalciferol deficiency.
The drug will be prescribed as part of complex therapy patients suffering from osteoporosis of various etiologies.

Mode of application

Chewable tablets Calcium-D3 Nycomed:
The drug is intended for oral use. The tablet can be swallowed whole, divided or chewed. The drug is taken regardless of meals. The duration of the course of treatment and the dose of the drug are determined by the attending physician individually for each patient.
To prevent calcium and cholecalciferol deficiency, adults and adolescents over 12 years of age are usually prescribed 1 tablet of the drug 1-3 times a day.

Adults and adolescents over 12 years of age suffering from osteoporosis are usually prescribed 1 tablet of the drug 2-3 times a day.

Chewable tablets Calcium-D3 Nycomed Forte:
The drug is intended for oral use. The tablet is swallowed whole or chewed with a small amount of liquid. The drug is taken regardless of meals. The duration of the course of treatment and the dose of the drug are determined by the attending physician individually for each patient:
Adults and adolescents over the age of 12 years for the purpose of prevention, as well as in complex therapy of osteoporosis, are usually prescribed 1 tablet of the drug 2-3 times a day.
To prevent calcium and cholecalciferol deficiency, adults and adolescents over the age of 12 years are usually prescribed 1 tablet of the drug 2 times a day.
To prevent calcium and cholecalciferol deficiency, children aged 5 to 12 years are usually prescribed 1 tablet of the drug 1-2 times a day.
The duration of the drug course is usually from 4 to 6 weeks. If necessary, the course of taking the drug is repeated several times a year.

Side effects

The drug is usually well tolerated by patients; in isolated cases, the following side effects have been observed:
From the gastrointestinal tract: stool disturbances, nausea, pain in the epigastric region, loss of appetite.
Allergic reactions: skin rash, itching, urticaria.
In addition, the development of hypercalcemia and hypercalciuria is possible.

Contraindications

Increased individual sensitivity to the components of the drug.
The drug is contraindicated in patients suffering from phenylketonuria.
The drug is not prescribed to patients with hypervitaminosis D3, elevated levels of calcium in the blood plasma and/or urine, as well as urolithiasis with the formation of calcium stones.
The drug is not used to treat patients suffering from severe renal failure and sarcoidosis.
The drug is not prescribed to children under 5 years of age.
The drug is prescribed with caution to patients with moderate renal failure, immobilized patients, and elderly patients.

Pregnancy

The drug can be prescribed during pregnancy.
Maximum daily dose calcium for women during pregnancy – 1500 mg, cholecalciferol – 600 MO.
When taking the drug during lactation, you should take into account the amount of calcium and vitamin D3 that enters the mother and child’s body with food.

Interaction with other drugs

The combined use of the drug with other drugs containing calcium and cholecalciferol is contraindicated.
When used in combination, the drug enhances the absorption of tetracycline antibiotics. An interval of at least 3 hours should be observed between doses of these drugs.
At simultaneous use the drug reduces the absorption of sodium fluoride and bisphosphonates. An interval of at least 2 hours should be observed between doses of these drugs.
Phenytoin and barbiturates, when used simultaneously with the drug, reduce the pharmacological effects of vitamin D3.
If it is necessary to use the drug simultaneously with drugs from the group of cardiac glycosides, the patient’s condition and ECG should be monitored.
Corticosteroids, when used in combination, reduce calcium absorption in the intestine.
Laxatives and cholestyramine, when used in combination with the drug, reduce the absorption of vitamin D3.
Thiazide diuretics reduce calcium excretion from the body, loop diuretics increase it. If it is necessary to use the drug in combination with diuretics, the level of calcium in the blood plasma should be monitored.

Overdose

When using excessive doses of the drug, as well as long-term use of the drug in doses exceeding the recommended ones, patients may develop hypercalcemia, the symptoms of which are nausea, vomiting, loss of appetite, dizziness, headache, weakness. In addition, it is also possible to develop hypercalciuria, increased creatinine levels in the blood, and coma. The development of polyuria and polydipsia are a sign of possible kidney damage caused by an overdose of the drug.
In case of overdose, discontinuation of the drug is indicated, administration large quantity fluids into the body, as well as a diet with reduced content calcium. In case of severe overdose of the drug, specific therapy is indicated, including glucocorticosteroids.

Release form

Chewable tablets Calcium-D3 Nycomed with orange flavor
Chewable tablets Calcium-D3 Nycomed with mint flavor 20, 50 or 100 pieces in bottles made of polymer materials, 1 bottle in a cardboard package.
Chewable tablets Calcium-D3 Nycomed Forte, 30, 60 or 120 pieces in bottles made of polymer materials, 1 bottle in a cardboard package.

Storage conditions

It is recommended to store the drug in a dry place away from direct sun rays at temperatures from 15 to 25 degrees.
The shelf life of the drug, regardless of the form of release, is 3 years.

Synonyms

Ideos, Vitrum Calcium.

Compound

Calcium-D3 Nycomed contains:

Cholecalciferol – 200MO;

1 chewable tablet Calcium-D3 Nycomed Forte contains:
Calcium carbonate – 1250 mg (in terms of calcium – 500 mg);
Cholecalciferol – 400MO;
Excipients, including aspartame.

Main settings

Name:	CALCIUM-D3 NYCOMED
ATX code:	A12AX -

Calcium D3 – a formula that has conquered the world. Almost everything preparations with calcium contain 3 , or cholecalciferol. No matter how different they are in names and additional components, calcium D3 - the basis of most remedies for bone fragility. Modern medicine It is impossible to imagine treating bone demineralization without these substances.

Why calcium D 3 poses a health risk?

At first sight osteoporosis treatment by using calcium D3 logical. Since bones are rapidly losing this mineral, it is necessary to take more of it. And the problem of poor absorption of calcium without a sufficient amount of cholecalciferol is easily solved by adding this vitamin to the medicine, which forces the body to take in the calcium it takes. It seems like the solution is as simple as shelling pears!

However, such simplicity turns out to be worse than theft - and the patient steals his own. And today, voices are increasingly heard about the dangers of excess calcium in the body. That osteoporosis treatment regimen using formula calcium D 3 is a vicious and ineffective practice. Let us consider the arguments of opponents of the generally accepted therapeutic approach.

Calcium deficiency- not a very common phenomenon, contrary to the advertising statements of the manufacturers. After all, calcium is present in abundance in foods and drinks, including the most common water. This is macro, not trace element!

The amount of calcium in the body must be judged by its content in the bones (using ), as well as in urine and blood (using tests). Unfortunately, most people are in no hurry to get tested, but drink it “for prevention” calcium D3 - it's always easy! Moreover, many do not even suspect that blood calcium level may be normal and even go off scale, despite brittle hair, destruction of teeth and bones.

Worse, without getting into the bone, the additional calcium, invariably absorbed thanks to, saturates the blood more and more. And in the blood its content should not go beyond a very narrow physiological framework (2.10–2.55 mmol/l). Exceeding the permissible threshold leads to the development of life-threatening conditions - hypercalcemia and calcinosis.

Hypercalcemia And calcification

Hypercalcemia – this is an excess of the norm of total calcium in the blood. Its consequences are disorders of the central nervous system (deterioration of mental activity, depression, coma), neuromuscular pathologies, nausea and vomiting, stomach ulcers, pancreatitis, diseases of the heart, blood vessels, kidneys, eyes...

Calcinosis , or calcification, - calcium deposits not at the address - at soft tissues and organs due to improper mineral metabolism. Calcification myocardium, blood vessels, lymph nodes, kidneys and lungs, muscles, gastrointestinal mucosa and other organs disrupts their functions and poses a mortal danger.

Both of these conditions can occur in patients with fractures and osteoporosis. Moreover, calcium leaching from bones is the leading cause of an increase in its level in the blood (hypercalcemia). Calcium D3 V loading doses for such patients it is simply poison.

Vitamin D 3 : both its shortage and its excess are dangerous!

Just like calcium, D3 (by nature it is a D3 hormone) – a double-edged sword. And blindly following advertising that calls for constantly replenishing the deficiency of the “sunshine” vitamin can lead to D-vitamin intoxication.

Vitamin D3 poisoning is expressed in thirst, vomiting, dehydration, anorexia, muscle weakness, increased blood pressure, increased frequency and interruptions heart rate, kidney damage, nervous pathologies, in hypercalcemia and calcinosis.

If you spend a lot of time in the sun in the summer, you can provide a year's supply of this substance. A menu rich in butter, cheese, milk, eggs and oily fish, also insures against hypovitaminosis D3. So you should be extremely careful with cholecalciferol!

Calcium D 3 : What do the studies say?

A five-year observation by English researchers of 24,000 people aged 35–64 years confirmed the risk premature death due to a heart attack or stroke in connection with taking calcium D3 supplements. Taking 1000 mg or more of calcium per day increases the risk of cardiovascular pathologies by 20%.

Unlike natural calcium, which comes from food and is absorbed little by little, large doses calcium D3 cause sharp jumps the level of calcium in the blood and its sedimentation inside the vessels and in the myocardium. The consequence of this is atherosclerosis.

U.S. experts The Preventative Services Task Force concluded in 2013 that daily intake healthy adults up to age 65 years of supplementation calcium D3 for strengthening bone tissue and preventing osteoporosis, it is not effective and may even be harmful. The likelihood of developing kidney stones doubles. An even more pronounced connection between the use of drugs calcium D3 with heart attacks indicate Swedish researchers.

Calcium D 3 at the epicenter of the paradoxes of modern medicine

A truly paradoxical situation has developed around drugs that include a complex calcium D3! Pharmacy windows are full of the following: “Calcium-D3 Nycomed”, “Complivit Calcium-D3”, “Natekal D3”, “Kalcemin”, “Vitrum Calcium”, etc. Doctors are well aware of all the dangers that are fraught with their use in large doses, but they invariably prescribe medications containing this insidious formula.

Because this is a classic and generally accepted approach to treatment of osteoporosis. Because the orthopedic traumatologist, prescribing lethal doses of calcium and cholecalciferol, is responsible only for the speedy fusion and does not worry about the patient’s blood vessels, heart, stomach or kidneys... Because in continuous medicine there is no individual approach to patients. Because doctors are following the aggressive lobbying of the interests of giant pharmaceutical companies promoting their drugs...

All these are topical problems of our medicine, but the worst thing is that under their pressure the very foundations of physiology are trampled. After all, in most cases the cause of demineralization of bone tissue is by no means lack of calcium, but the impossibility of its absorption by the bones! This means that the solution to the problem is not to poison the body with calcium, but to deliver it to the exact address - to the bone.

Why do bones stop absorbing calcium with age? Because as hormonal activity fades, fewer and fewer young bone cells - osteocytes - are born. And since they are the most important participants in the mineralization of bone tissue, calcium remains unclaimed by the bone. Think about it: will there be any use in extra calcium, if the body does not know where to put what it already has? Have you guessed where the calcium not taken up by the bones will be stored?..

Is it possible to force calcium D 3 work to prevent and treat osteoporosis?

Still, don’t rush to write it off calcium D3 off the books! You just need to make it work for you, that is, help the macroelement get into the demineralized bone, direct it to emergency healing of the fracture. But how to achieve this?

Stimulating osteogenesis (the birth of new osteocytes) is the only correct approach to treatment of osteoporosis. Since the main anabolic hormone for all species is testosterone, osteogenesis can be enhanced by increasing testosterone level in organism.

Here the question arises about safe method increase testosterone. Introducing it from outside, or , is fraught with the development of dangerous ones, including oncology, and the final suppression of the synthesis of one’s own hormone. This is not a solution - to treat one thing while crippling other systems and organs.

Search safe ways stimulation of testosterone production led specialists from the Russian pharmaceutical company Parapharm to the idea of ​​using unique properties drone homogenate to improve bone formation.

– a source of insect hormones – testosterone, prolactin, progesterone and estradiol. But for a person it's just prohormones, which help him produce his own testosterone more intensively, which in turn stimulates osteogenesis. And young osteocyte cells will be able to attract calcium and begin to mineralize bone tissue.

Osteomed Forte: return of prodigal calcium

Incorporation of drone homogenate into an anti-osteoporotic drug containing (250 mg), vitamin D3 (1.5 mg) and vitamin B6 (0.5 mg), became a revolutionary solution. Drone homogenate it's not easy here excipient, but an important anabolic component that helps calcium get to the right address, and not settle in soft tissues. Thanks to him, calcium in the composition Forte gains not only effectiveness, but also safety.

To the benefits of the product Osteomed Forte it is necessary to include a relatively low dosage of calcium. placed emphasis not on its quantity, but on quality: calcium citrate– the most digestible and harmless form of this mineral. Better less, but better, as intended and straight to the target!

Addition vitamin B6 accelerates bone mineralization by improving the absorption and transport of magnesium into cells. And magnesium - faithful companion and calcium assistant in bone mineralization.

Not only does it safely increase mineral tissue, but it also promotes closure cavity formations in the bones, which is a new word in treatment of osteoporosis. Calcium D3 here it works one hundred percent. Osteomed Forte– this is the return of prodigal calcium home! This is smart calcium not into the blood, but into the bone!

USEFUL TO KNOW:

ABOUT CALCIUM

Let's say right away: sources of calcium are not scarce. But here’s the paradox: the body may experience a lack of it. And women feel it more often than men. This is when split ends are sent to the hairdresser to get a boy's haircut. Brittle nails cry out for extensions, not to mention teeth, the chronic restoration of which literally undermines the family budget. But the worst thing that comes from calcium deficiency...

Calcium D3 Nycomed is a drug based on two main components - calcium and vitamin D3, which is also called cholecalciferol.

In turn, calcium is vital important element for teeth, bones, bone covers and even neurotransmission in the central and peripheral nervous system person. In addition, the drug balances the synthesis of parathyrin, a failure in the production of which can result in the appearance of periodic processes of destruction of bone tissue.

On this page you will find all the information about Calcium D3 Nycomed: full instructions as applied to this medicine, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Calcium D3 Nycomed. Would you like to leave your opinion? Please write in the comments.

Clinical and pharmacological group

A drug that regulates the metabolism of calcium and phosphorus.

Conditions for dispensing from pharmacies

Available without a prescription.

Prices

How much does Calcium D3 Nycomed cost? The average price in pharmacies is 400 rubles.

Release form and composition

The drug is manufactured and available in the form of chewable tablets with lemon, orange and mint flavors.

Tablets with orange flavor are produced without a shell, round shape and white. Calcium-D3 Nycomed with orange contains the main substances:

• calcium carbonate – 1250 milligrams;
• vitamin D3 – 5.0 mcg (200 IU);

and minor elements:

• isomaltitol – 62.0 mg;
• glucite – 390 mg;
• orange olive – 0.97 mg;
• di and monoglycerides of carboxylic fatty acids – 0.08 mcg.

The products are produced in boxes of 20, 50, 100 pieces per box.

The mint-flavored product, which is also available on store shelves, is completely similar in composition to orange tablets.

The only difference between them is that instead of orange oil, the drug contains mint flavor essence. Available in polyethylene bottles high density 30 and 100 pieces.

Chewable tablets with lemon flavor are somewhat different from other types in their composition, and, more precisely, in the amount of elements they contain. They are called Calcium D3 Nycomed Forte.

Primary substances:

• calcium carbonate – 1250 mg;
• equivalent to regular Ca – 500 mg;
• cholecalciferol – 10.0 mcg (400 IU);
• colecalciferol concentrate – 4.0 mg;

and additional elements:

• Zomaltit – 49.9 mg;
• povidone (enterosorbent) – 36.4 mg;
• magnesium stearate – 6.00 mg;
• L-Aspartyl-L-phenylalanine – 1.00 mg;
• glucite – 390 mg;
• lemon oil – 0.78 mg;
• di- and monoglycerides of carboxylic fatty acids – 0.0006 mg.

The product is released in polyethylene bottles of 30, 60, 120 pieces.

Pharmacological effect

The drug belongs to the combination pharmaceuticals, which regulate the exchange of calcium and phosphorus in the body and compensate for the deficiency of the main structural element.

The biochemical role of calcium lies in the physiological construction of bone tissue, mineralization of teeth, the processes of coagulation and transmission of nerve impulses, and the implementation of muscle contractions. In response to its increase in the systemic circulation, bone tissue density increases and calcium excretion by the kidneys decreases.

Cholecalciferol is responsible for the absorption processes of the element in the gastrointestinal tract and its distribution in the body. Oral administration of the drug inhibits the synthesis of parathyroid hormone, a natural hormone. parathyroid gland, which significantly affects phosphorus-calcium metabolism. Accordingly, the amount of calcium absorbed from the digestive tube increases and its resorption (leaching) from bones and other organs decreases.

Indications for use

Taking Calcium D3 Nycomed tablets is indicated in the following cases:

• Preventing the development of complications of osteoporosis – pathological decline level of minerals in bone tissue, which is accompanied by a significant decrease in its strength and frequent fractures.
• Treatment and prevention of conditions that are associated with insufficient levels of calcium or vitamin D3 in the body (hypovitaminosis and hypocalcemia).

The indications for taking the drug are determined by the doctor based on clinical picture and the results of additional examination confirming the presence pathological process in organism.

Contraindications

According to the instructions, Calcium D3 Nycomed cannot be used for:

• hypercalcemia;
• nephrolithiasis;
• hypercalciuria;
• severe renal failure;
• active form of tuberculosis;
• hypervitaminosis D;
• sarcoidosis;
• and also up to three years of age;
• high level of sensitivity of the body to the components included in the drug, peanuts or soy.

The drug should also not be taken by persons with phenylketonuria, since it contains aspartame, which is transformed in the body into phenylalanine.

It is also not recommended to take the drug for persons with glucose-galactose malabsorption, hereditary intolerance fructose, sucrase-isomaltase deficiency, since the tablets of the drug contain isomalt, sorbitol, and sucrose.

Use during pregnancy and lactation

Calcium and vitamin D3 are used during pregnancy to compensate for their deficiency in the body.

During pregnancy, the daily dose of the drug should not exceed 1500 mg of calcium and 600 IU of vitamin D3. Hypercalcemia due to overdose during pregnancy can have an adverse effect on the developing fetus.

The drug is used during lactation. Calcium and vitamin D3 can penetrate into breast milk, therefore it is necessary to consider the intake of calcium and vitamin D from other sources in the mother and child.

Instructions for use

The instructions for use indicate that Calcium D3 Nycomed tablets can be chewed or dissolved and taken with meals.

• Adults for the prevention of osteoporosis - 1 tablet. 2 times/day; in complex therapy of osteoporosis - 1 tablet. 2-3 times/day.
• To replenish calcium and vitamin D deficiency, adults and children over 12 years old - 1 tablet. 2 times/day, children from 5 to 12 years old - 1-2 tablets/day, children from 3 to 5 years old - dosage in accordance with doctor's recommendations.

Duration of treatment:

1. When used for prevention and in complex therapy of osteoporosis, the duration of treatment is determined by the doctor individually.
2. When used to compensate for calcium and vitamin D3 deficiency average duration course of treatment for at least 4-6 weeks. The number of repeat courses during the year is determined individually.

Patients with impaired liver function do not require dose adjustment.

Should not be used in severe renal failure.

Elderly patients are prescribed the same dose as for adults. A possible decrease in CC should be taken into account.

Side effects

During therapy, undesirable reactions may occur:

1. Allergic reactions: very rare - skin rashes, itching, urticaria;
2. Laboratory indicators: infrequently - hypercalciuria and hypercalcemia ( increased content calcium in urine or blood);
3. From the outside digestive system: rarely - gastrointestinal dysfunction (increased formation of gases in the intestines, abdominal pain, nausea, dyspepsia, diarrhea or constipation).

Overdose

An overdose of calcium is fraught with the development of hypercalcemia, its symptoms: thirst, muscle weakness, abdominal pain, constipation, nausea, vomiting, polyuria, fatigue, anorexia, bone pain, urolithiasis disease, nephrocalcinosis, mental disorders. In severe cases, cardiac arrhythmias are added.

With long-term use in excessive doses (more than 2500 mg of calcium), kidney damage and soft tissue calcification are possible. If any of the described symptoms appear, you should stop taking Calcium-D3 Nycomed and consult a doctor. First aid for overdose involves gastric lavage, then a loop diuretic (for example, furosemide), glucocorticosteroid, calcitonin and bisphosphonates are prescribed, and replenishment of lost fluid is also indicated. It is necessary to monitor diuresis, renal function and electrolyte levels in the blood; in severe cases, ECG monitoring and measurement of central venous pressure are required.

Hypercalcemia that develops as a result of overdose during pregnancy can have an adverse effect on the fetus.

special instructions

1. To avoid overdose, it is important to consider additional vitamin D intake from any other sources, including food.
2. It is not recommended to prescribe quinolone and tetracycline antibiotics at the same time. If the use of such combinations is justified, caution should be exercised.
3. The drug should be used with caution in the treatment of patients with osteoporosis if they are immobilized, since this category is at increased risk of developing hypercalcemia.

At long-term use of the drug, it is necessary to monitor the level of calcium and creatinine in the blood serum, especially in elderly people receiving concomitant diuretics and/or cardiac glycosides, as well as in patients with an increased tendency to form kidney stones. If symptoms of impaired renal function or the development of hypercalcemia appear, the dose of Calcium-D3 Nycomed Forte should be reduced or discontinued altogether.

Drug interactions

Calcium absorption is reduced by glucocorticosteroids, so an increase in the dose of the supplement may be required.

Hypercalcemia that develops as a result of taking a mineral supplement can potentiate the toxic effects of cardiac glycosides. Monitoring serum calcium concentration and ECG monitoring is necessary.

Calcium reduces absorption and reduces the effectiveness of levothyroxine, so the interval between doses should be at least 4 hours. Bisphosphonates, if necessary, are recommended to be taken no later than 1 hour before taking Calcium-D3Nycomed.

It is not recommended to take the drug simultaneously with tetracycline antibiotics and quinolone, since their absorption is reduced. If such a combination is still necessary, it is recommended to take these medications 2 hours before or 4-6 hours after taking Calcium-D3Nycomed. The patient must be under close medical supervision throughout the entire treatment period.

The risk of developing hypercalcemia increases with simultaneous use of thiazide diuretics. In this case, it is necessary to regularly monitor the concentration of calcium in the blood serum.

The body needs calcium and vitamins D in relatively large quantities. They are involved in many processes, so a lack of this mineral almost instantly leads to various problems with health.

At the same time, it is very simple to wash these elements from the body; it will be enough:

1. Drink sweet carbonated water regularly.
2. Smoking.
3. Love sweets.
4. Drink coffee, strong tea.
5. Take x-rays more than 2 times a year.

To restore the level of the substance, it is necessary to use special medications, one of the most effective among which is Calcium D3 Nycomed.

What is the drug and its composition?

Available in chewable tablets.

There are 3 flavors, as well as a drug with an increased dosage of cholecalciferol (Forte):

• orange. 20, 50 or one hundred pieces in a bottle;
• mint or lemon. Same number of tablets, same packaging;
• forte. 30, 60 or 120 pieces;

1 capsule contains:

1. Calcium carbonate– 1.25 grams, translated into pure microelement 0.5 grams.
2. Cholecalciferol or vitamin D3. About 0.005 milligrams. The presence of the prefix forte indicates that the amount of the substance is doubled.

Additional components, namely:

• aspartame;
• sorbitol;
• magnesium stearate;
• oils (orange, lemon, peppermint oil, which is responsible for taste);

Indications for use

1. Osteoporosis. Chronic illness characterized by decreased bone density. It can occur in almost anyone.
2. Hypocalcemia. Disruption of electrophysiological processes at the cellular level manifests itself extremely low level serum calcium. It can be caused by a huge number of reasons.
3. Osteomolation. In case of metabolic disturbance minerals a disease appears that causes softening of the bones.
4. If necessary, saturate the body with calcium, a vitamin from group D. Acts as a vitamin complex.
5. Recommended for use during pregnancy or lactation to replenish lost elements that the composition is rich in chewable tablet. But the dosage is selected individually, only by a doctor.

pharmachologic effect

This combination drug restores the normal exchange of phosphorus and calcium at the cellular level, as well as:

1. Reduces resorption, therefore increases bone density.
2. Reduces the amount of parathyroid hormone, which is responsible for metabolic processes in bone tissue.
3. Vitamin D3 regulates the absorption of calcium in the intestines and its transport to internal organs;

The active elements of the tablets are well absorbed digestive tract, are output at the stage of passing through small intestine. A little cholecalciferol settles in the liver, forming active metabolites. The elements are then able to be excreted through the corresponding glands.

Instructions for use

The tablet can be swallowed whole, divided into parts, or chewed. There is no attachment to food.

With several doses, it is necessary to divide the day into equal intervals at which the drug is taken.

Reception:

1. Over 12 years old. For prevention, the recommended dose is 1 tablet up to 3 times a day.
2. Children from 5 to 12 years old– 1 capsule up to 2 times a day.
3. The drug can be taken by children over 3 years of age. The dose is determined by the pediatrician.

The duration of the full course is up to 42 days. If necessary, administration can be done several times throughout the year. The dosage and duration of the course are determined only by the doctor.

Contraindications and side effects

There are several cases when the use of the product is contraindicated:

1. Individual intolerance to the components.
2. Renal failure in a pronounced form.
3. Increased levels of calcium and vitamin D3.
4. Children under 3 years old.
5. Dementia, developmental delay due to phenylketonuria.

Side effects:

1. Disorders of the gastrointestinal tract ( loose stool, nausea, vomiting).
2. Allergic reactions (hives, itching and others).
3. Hypercalcemia, hypercalciuria (increased calcium levels in the blood and urine, respectively).

However, it should be noted that the human body almost always tolerates the drug normally, side effects occur extremely rarely.

Price and possible analogues

To understand the price characteristics, we took the assortment of one of the online pharmacies with Moscow registration.

At the same time, taste does not affect the cost, you just can’t find all 3 everywhere:

There are analogues where the set active ingredients completely similar according to the international classification:

• Kalcemin Advance (Switzerland). 30 capsules for 210 rubles;
• Calcium D (India). 30 pieces for 165 rubles;
• Calcemin (USA). 30 tablets for 180 rubles;
• Ka asset (Russia). The price starts from 150 rubles. It is distinguished by a slightly more meager composition;

Name: Calcium-D3 Nycomed

Active substance

Calcium carbonate + Colecalciferol*

ATX

A12AX Calcium supplements in combination with vitamin D and/or other medications

Pharmacological groups

• Calcium-phosphorus metabolism regulator [Bone and bone metabolism correctors cartilage tissue in combinations]
• Calcium-phosphorus metabolism regulator [Vitamins and vitamin-like products in combinations]

Compound

Description of the dosage form

Round, biconvex, uncoated, white tablets with orange or mint flavor. May have small inclusions and uneven edges.

pharmachologic effect

Pharmacological effect - replenishes the deficiency of calcium and vitamin D3.

Pharmacodynamics

A combined drug that regulates the exchange of calcium and phosphorus in the body (bones, teeth, nails, hair, muscles). Reduces resorption (resorption) and increases bone density, replenishing the lack of calcium and vitamin D3 in the body, necessary for the mineralization of teeth. Calcium is involved in the regulation of nerve conduction, muscle contractions and is considered a component of the blood coagulation system.

Vitamin D3 increases calcium absorption in the intestines. The use of calcium and vitamin D3 interferes with the production of parathyroid hormone (PTH), which is thought to stimulate increased bone resorption (the leaching of calcium from the bones).

Pharmacokinetics

Calcium

Suction. Often, the amount of calcium absorbed in the gastrointestinal tract is somewhere around 30% of the dose taken.

Distribution and metabolism. 99% of the calcium in the body is concentrated in the rigid structure of bones and teeth. The remaining 1% is found in intra- and extracellular fluids. About 50% of general content calcium in the blood is in a physiologically active ionized form, of which about 10% is complexed with citrate, phosphate or other anions, the remaining 40% is associated with proteins, primarily with albumin.

Excretion. Calcium is excreted by the intestines, kidneys and sweat glands. Renal excretion depends on glomerular filtration and tubular reabsorption of calcium.

Vitamin D3

Suction. Vitamin D3 is easily absorbed into small intestine(about 80% of the accepted dosage).

Distribution and metabolism. Colecalciferol and its metabolites circulate in the blood bound to a specific globulin. Colecalciferol is converted in the liver by hydroxylation to 25-hydroxycolecalciferol. It is then converted in the kidneys to the active form 1,25-hydroxycolecalciferol. 1,25-hydroxycolecalciferol is considered a metabolite responsible for increasing calcium absorption.

Unmetabolized vitamin D3 is stored in adipose and muscle tissue.

Excretion. Vitamin D3 is excreted by the intestines and kidneys.

Indications for the drug Calcium-D3 Nycomed

prevention and treatment of calcium and/or vitamin D3 deficiency;

prevention and complex therapy of osteoporosis and its complications.

Contraindications

hypersensitivity to the components of the drug;

hypersensitivity to soy or peanuts;

hypercalcemia, hypercalciuria;

nephrolithiasis;

hypervitaminosis D;

severe renal failure;

active form of tuberculosis;

sarcoidosis;

children's age (up to 3 years).

Carefully:

pregnancy;

lactation period.

renal failure.

Calcium-D3 Nycomed contains aspartame, which is transformed into phenylalanine in the body. Therefore, the drug should not be taken by patients with phenylketonuria.

The drug contains sorbitol, isomalt and sucrose, so its use is not recommended for patients with hereditary fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase deficiency.

Use during pregnancy and breastfeeding

Calcium-D3 Nycomed is used during pregnancy to replenish calcium and vitamin D deficiency in the body.

The daily dosage should not exceed 1500 mg of calcium and 600 IU of vitamin D3.

Hypercalcemia, which develops against the background of an overdose during pregnancy, can have adverse influence on the developing fetus.

Calcium-D3 Nycomed is used during lactation.

Vitamin D and its metabolites can pass into breast milk, so the intake of calcium and vitamin D from other sources in the mother and baby must be considered.

Side effects

Itching, rash, urticaria, gastrointestinal dysfunction (constipation or diarrhea, flatulence, nausea, abdominal pain, dyspepsia), hypercalcemia and hypercaliciuria.

Interaction

Hypercalcemia may potentiate the toxic effects of cardiac glycosides when used concomitantly with calcium and vitamin D medications. Monitoring of ECG and serum calcium levels is necessary.

Calcium supplements may reduce the absorption of tetracyclines from the gastrointestinal tract. Therefore, tetracycline drugs should be taken at least 2 hours before or 4–6 hours after taking Calcium-D3 Nycomed.

To prevent decreased absorption of bisphosphonate drugs, it is recommended to take them at least an hour before taking Calcium-D3 Nycomed.

GCS reduce the absorption of calcium, so treatment with GCS may require an increase in the dosage of Calcium-D3 Nycomed.

With the simultaneous use of thiazide diuretics, the risk of hypercalcemia increases, because they increase tubular reabsorption of calcium. When using thiazide diuretics simultaneously, serum calcium levels should be regularly monitored.

Calcium reduces the effectiveness of levothyroxine by reducing its absorption. The period of time between doses of levothyroxine and Calcium-D3 Nycomed should be at least 4 hours.

The absorption of quinolone antibiotics is reduced when used simultaneously with calcium medications. Therefore, quinolone antibiotics should be taken 2 hours before or 6 hours after taking Calcium-D3 Nycomed.

Reception food products containing oxalates (sorrel, rhubarb, spinach) and phytin (cereals) reduces calcium absorption, so you should not take Calcium-D3 Nycomed within 2 hours after eating sorrel, rhubarb, spinach, cereals.

Directions for use and doses

In complex therapy of osteoporosis: adults - 1 tablet. 2-3 times a day; to prevent osteoporosis - 1 table. 2 times a day.

For calcium and vitamin D deficiency: adults and children over 12 years old - 1 table. 2 times a day; children from 5 to 12 years old - 1–2 tablets. in a day; 3–5 years - dosage in accordance with the doctor’s recommendations.

Special patient groups

Patients with impaired liver function. No dosage adjustment is required.

Patients with impaired renal function. The drug Calcium-D3 Nycomed should not be used in case of severe renal failure.

Elderly patients. The dosage is the same as for adults. A possible decrease in creatinine clearance should be taken into account.

Duration of treatment. When used for the prevention and complex therapy of osteoporosis, the duration of treatment is determined by the doctor individually.

When used to replenish calcium and vitamin D3 deficiency, the average duration of treatment is at least 4–6 weeks. The number of repeat courses during the year is determined individually.

Overdose

Symptoms of overdose (hypercalcemia): anorexia, thirst, polyuria, muscle weakness, nausea, vomiting, constipation, abdominal pain, fatigue, bone pain, mental disorders, nephrocalcinosis, urolithiasis and, in severe cases, cardiac arrhythmias. With long-term use of excessive doses (over 2500 mg of calcium) - kidney damage, soft tissue calcification.

If signs of overdose are detected, you should stop taking calcium and vitamin D, as well as thiazide diuretics and cardiac glycosides, and consult a doctor.

Treatment: gastric lavage, replenishment of fluid loss, use of loop diuretics (in particular furosemide), corticosteroids, calcitonin, bisphosphonates. It is necessary to monitor the content of electrolytes in the blood plasma, renal function and diuresis. In severe cases, measurement of central venous pressure (CVP) and ECG monitoring are necessary.

special instructions

During long-term therapy, serum calcium and creatinine levels should be monitored.

Monitoring is especially important in elderly patients during simultaneous treatment with cardiac glycosides and diuretics (see “Interaction”) and in patients with an increased tendency to form kidney stones. In cases of hypercalcemia or signs of renal dysfunction, reduce the dose or discontinue treatment.

Vitamin D should be taken with caution in patients with renal failure. In this case, it is necessary to monitor the calcium and phosphate levels in the blood serum. You also need to consider the risk of soft tissue calcification.

To avoid overdose, additional vitamin D intake from other sources must be taken into account.

Calcium and vitamin D3 should be used with caution in immobilized patients with osteoporosis due to the risk of hypercalcemia.

Concomitant use with tetracycline or quinolone antibiotics is often not recommended, or should be done with caution (see “Interactions”).

Release form

Chewable tablets (orange). 20, 50 or 100 tablets. in a HDPE bottle, sealed with a screw cap, under which there is a ring for tearing off the sealing gasket, ensuring control of the first opening. 1 fl. placed in a cardboard box.

Chewable tablets (mint). 30 or 100 tablets. in a HDPE bottle, sealed with a screw cap, under which there is a ring for tearing off the sealing gasket, ensuring control of the first opening. 1 fl. placed in a cardboard box.

Manufacturer

Nycomed Pharma AS, Norway.

Conditions for dispensing from pharmacies

Over the counter.

Storage conditions for the drug Calcium-D3 Nycomed

In a dry place, at a temperature not exceeding 25 °C, in a tightly closed bottle.

Keep out of the reach of children.

Shelf life of the drug Calcium-D3 Nycomed

Do not use after the expiration date stated on the packaging.