Omez and omeprazole are analogues with equal effectiveness. Omeprazole: analogues and substitutes, modern and without side effects Omeprazole analogues are cheaper
Medicines to treat excess stomach acid and peptic ulcer are very popular. Let's look at the most accessible and popular inhibitors proton pump(drugs of this class are usually called abbreviated as PPI or PPI), which are based on active substance omeprazole and rabeprazole (slightly modified analogue of the first).
The drug Omeprazole10 popular analogues of omeprazole and rabeprazole
- Omez (omeprazole). The drug is made in India. Advantages: a variety of dosages, the presence of an injection form, which increases bioavailability, the cost is lower than other analogues, but higher than that of omeprazole. Disadvantages: maximum concentration is achieved after long time, the half-life is short. The average price per package is about 170 rubles.
- Ultop (omeprazole). Manufacturer: Russia or Slovenia. Advantages: different dosages, injection forms, high bioavailability, long half-life, relatively low cost (80-90 rubles). Disadvantages: long time to create maximum concentration.
- Losec (omeprazole). Country Sweden. Advantages: injection form, maximum concentration is achieved in a short time. Disadvantages: high price among all analogues - 1800 rubles.
- Gastrozole (omeprazole). Russia. It is characterized by high bioavailability, relatively low cost (100 rubles), and a variety of packaging (cans, blisters). Disadvantages: only one dosage, shortened half-life.
- Orthanol (omeprazole). Slovenia. Advantages: long half-life, variety of dosages, average price (90-100 rubles). Disadvantages: maximum concentration is achieved over a long period of time.
- Helicide (omeprazole). Czech Republic. The bioavailability of capsules is higher than their analogues, the availability of injection forms. The downside is the high price (260-290 rubles).
- (rabeprazole). Switzerland, Japan, Belgium. The disadvantage is the high price (1000-1300 rubles).
- Rabeloc (rabeprazole). India. Pros: form for intravenous administration(lyophilisate), providing high bioavailability. Cost from 300 rub.
- Ontime (rabeprazole). Israel. It has the lowest bioavailability of all substitutes. Cost 500 rub.
- Zolispan (rabeprazole). Spain. High bioavailability and half-life.
Drugs for the treatment of excess stomach acidity and peptic ulcers are very popular. Let's consider the most accessible and popular proton pump inhibitors (drugs of this class are usually called by the abbreviation PPI or PPI), which are based on the active substance omeprazole and rabeprazole (a slightly modified analogue of the first).
The drug Omeprazole
10 popular analogues of omeprazole and rabeprazole
- Omez (omeprazole). The drug is made in India. Advantages: a variety of dosages, the presence of an injection form, which increases bioavailability, the cost is lower than other analogues, but higher than that of omeprazole. Disadvantages: the maximum concentration is reached over a long time, the half-life is short. The average price per package is about 170 rubles.
- Ultop (omeprazole). Manufacturer: Russia or Slovenia. Advantages: different dosages, injection forms, high bioavailability, long half-life, relatively low cost (80-90 rubles). Disadvantages: long time to create maximum concentration.
- Losec (omeprazole). Country Sweden. Advantages: injection form, maximum concentration is achieved in a short time. Disadvantages: high price among all analogues - 1800 rubles.
- Gastrozole (omeprazole). Russia. It is characterized by high bioavailability, relatively low cost (100 rubles), and a variety of packaging (cans, blisters). Disadvantages: only one dosage, shortened half-life.
- Orthanol (omeprazole). Slovenia. Advantages: long half-life, variety of dosages, average price (90-100 rubles). Disadvantages: maximum concentration is achieved over a long period of time.
- Helicide (omeprazole). Czech Republic. The bioavailability of capsules is higher than their analogues, the availability of injection forms. The downside is the high price (260-290 rubles).
- Pariet (rabeprazole). Switzerland, Japan, Belgium. The disadvantage is the high price (1000-1300 rubles).
- Rabeloc (rabeprazole). India. Pros: form for intravenous administration (lyophilisate), providing high bioavailability. Cost from 300 rub.
- Ontime (rabeprazole). Israel. It has the lowest bioavailability of all substitutes. Cost 500 rub.
- Zolispan (rabeprazole). Spain. High bioavailability and half-life.
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The site provides background information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!
The drug Omeprazole
A drug Omeprazole refers to the most modern antisecretory drugs used in the treatment of peptic ulcers and erosive-inflammatory diseases upper section gastrointestinal tract. According to the mechanism of action, it relates to proton pump inhibitors.Omeprazole suppresses the production of hydrochloric acid in the stomach and reduces its activity. This drug acquires its medicinal properties only after entering an acidic environment, which is precisely characteristic of the stomach.
After ingestion, the drug actively penetrates into special cells of the stomach responsible for the secretion of hydrochloric acid. It accumulates in them and, thus, regulates the production process gastric juice and pepsin (an enzyme that breaks down proteins).
Omeprazole has a bactericidal effect on the main “culprit” of gastritis and peptic ulcers – the microorganism Helicobacter pylori. This is why Omeprazole is mandatory is included in the list of drugs that suppress Helicobacter pylori infection for stomach and duodenal ulcers.
With pathological reflux of gastric contents into the esophagus (reflux ulcerative and erosive esophagitis) the mucous membrane is inevitably damaged, and ulcerative defects. Omeprazole, taken orally, can reduce the damaging effects of hydrochloric acid, restore the pH of gastric juice and significantly reduce the severity of the main symptoms of the disease.
Omeprazole not only significantly improves the well-being of patients, but also leads to sharp decline the likelihood of the disease returning and the development of its complications. Its action begins within 1 hour after ingestion and continues throughout the day. Omeprazole reaches its therapeutic maximum after 2 hours. The higher the dose of the drug, the stronger the inhibitory effect on the parietal (hydrochloric acid-producing) cells of the stomach.
Omeprazole is excreted from the body through the kidneys (up to 80%) and intestines (about 20%). In older people, as well as with chronic renal failure, the removal of the drug from the body may be slowed down.
Release forms
In the pharmacy chain, the drug Omeprazole is sold in tablets, capsules and solutions for intravenous administration. 1. Enteric capsules contain 10 mg or 20 mg of the main active ingredient - omeprazole (7 capsules in a blister pack, a pack can contain from 1 to 4 blister plates); some manufacturers package capsules in polymer jars of 30 or 40 pieces;
2. MAPS tablets (pellets), film-coated, 10 mg, 20 mg or 40 mg active substance (№ 7, 14, 28);
3. Powder for infusion solutions in 40 mg bottles (5 bottles per package).
The drug is available only with a doctor's prescription.
Instructions for use of Omeprazole
Indications for use
Omeprazole has wide indications for diseases of the upper gastrointestinal tract. The drug is usually prescribed to adults and children over 5 years of age in the following cases:1. IN complex treatment active phase of gastric and duodenal ulcers associated with Helicobacter pylori infection;
2. For the treatment of Zollinger-Ellison syndrome;
3. To relieve manifestations of gastroesophageal reflux (reflux of gastric contents into the lower part of the esophagus);
4. To eliminate uncomplicated heartburn that lasts more than 2 days during the week;
5. As a course of treatment of endoscopically confirmed erosive esophagitis;
6. For the correction of hypersecretory disorders in the upper part digestive tract;
7. For the treatment of gastropathy caused by taking non-steroidal anti-inflammatory drugs;
8. In the combined treatment of polyendocrine adenomatosis;
9. Prophylactically, to prevent relapse in chronic duodenal ulcers, aspirin and stress peptic ulcers.
Contraindications
The main contraindication for taking Omeprazole is intolerance to any of the components of the drug.In addition, the drug is not recommended to be taken during pregnancy. It has been clinically proven that taking Omeprazole, especially in the first trimester of pregnancy, can lead to malformations in the fetus. Therefore, the drug is prescribed only in extreme cases, when the benefits of its use significantly outweigh the side effects.
The drug penetrates well and quickly into the blood and breast milk, so it is not prescribed during lactation.
Omeprazole helps reduce the acidity of gastric juice; therefore, it is not prescribed for gastritis with low acidity or atrophic gastritis.
Omeprazole is also contraindicated in patients with suspected oncological pathology of the stomach or duodenum. In this case, the drug can neutralize the existing symptoms and complicate the final diagnosis. There is evidence that Omeprazole in this pathology can stimulate the growth of an existing tumor.
Other contraindications include osteoporosis and a tendency to spontaneous bone fractures. Omeprazole leaches calcium from bones, so it can increase the effects of osteoporosis. In case of emergency, treatment with Omeprazole under the cover of calcium and vitamin D supplements is allowed.
Before prescribing Omeprazole, you must ensure that the patient does not have the following conditions:
- Malignant tumors of the digestive tract;
- Gastrointestinal infections - salmonella, compylobacter, because Omeprazole may enhance their reproduction;
- Liver failure - in this case, the biotransformation of the drug sharply slows down and toxic inflammation of liver cells occurs;
- Kidney failure slows down the elimination of the drug from the body.
Side effects
Side effects from taking Omeprazole are quite rare. As a rule, they occur with improper or prolonged use of the drug (more than 2-3 months in a row). In these cases, the most commonly observed disorders are the digestive organs - nausea, bloating and abdominal pain, diarrhea or constipation. Some patients complain of headaches and dizziness. All symptoms usually go away on their own after discontinuation of the drug. In addition, Omeprazole may cause:
- Violation taste sensations, dryness and inflammation of the oral mucosa.
- Nausea, vomiting, unstable stool, flatulence.
- Liver dysfunction.
- Violations by nervous system(in patients with severe concomitant diseases) – depression, increased irritability, headache, lethargy, weakness, and sometimes encephalopathy.
- Skin rashes, itching, redness and peeling, exudative erythema, increased sensitivity to the light, local baldness.
- Allergic reactions in the form of fever, urticaria, Quincke's edema, bronchial muscle spasm, interstitial nephritis; in very rare cases - anaphylactic shock.
- Changes in the qualitative and quantitative composition of the blood - a decrease in the number of leukocytes, platelets; B12-folate deficiency anemia sometimes develops.
- Sometimes observed painful sensations V large joints and muscles, and muscle weakness develops.
Treatment with Omeprazole
Due to the fact that it is incorrect or uncontrolled reception the drug may cause serious harm gastrointestinal tract, it can only be prescribed by a doctor.How to take Omeprazole?
Omeprazole should be taken immediately before meals or during breakfast. If it is necessary to take the drug again during the day, it is usually prescribed in the evening.
Capsules should not be chewed or divided into pieces. Take the required dose of the drug a small amount pure still water.
If as remedy Omeprazole tablets (pellets) are used; they can be dissolved in acidified water, yogurt or juice (15-20 ml). The diluted drug should be drunk within 30 minutes.
Omeprazole dosage
Standard single dose The dose of the drug is 20 mg, but it can be adjusted by the doctor depending on the severity of the disease and general condition patient. Omeprazole is prescribed in courses of no more than 2 months, after which a break of several months is necessary.
- For gastric ulcers in the acute stage, Omeprazole is prescribed 20-40 mg per day, the dose is divided into 2 doses. The course of treatment is from 1 to 2 months.
- For erosive-ulcerative esophagitis, treatment is prescribed in the same way as gastric ulcer. As anti-relapse treatment, 20 mg of Omeprazole per day is prescribed. The duration of treatment can be from 1 to 2 months.
- At duodenal ulcers daily dose drug – 20 mg, course of treatment – 2-4 weeks. To prevent relapse of the disease, maintenance doses of Omeprazole are prescribed for up to 4 weeks. In this case, it is necessary to use capsules containing 10 mg of the main active ingredient.
- At gastropathy And erosive and ulcerative lesions caused by taking non-steroidal anti-inflammatory drugs, 1 capsule of Omeprazole per day is prescribed for a period of 4 to 8 weeks.
- For treatment Zollinger-Ellison syndrome The dose of Omeprazole is selected strictly individually, depending on the initial level of gastric secretory activity. The minimum daily dose is 60 mg. In the future, the dose can be increased to 120 mg/day, with the amount of the drug divided into 2 doses - morning and evening.
- For treatment Helicobacter pylori infection Take 20 mg of the drug in the morning and evening, the minimum course is 7 days. In this treatment, omeprazole is always taken together with antibacterial agents, according to one of the existing schemes (triple or quadruple therapy).
- For cupping uncomplicated heartburn Omeprazole 20 mg is prescribed once a day for 14 days. A second course of treatment is possible after 4 months.
- In patients with concomitant liver diseases, the daily dose of the drug should not exceed 20 mg.
- For prevention leakage of acidic stomach contents into the esophagus during long operations Omeprazole is prescribed 40 mg the day before and 2-4 hours before surgery.
Omeprazole for children
The drug is usually not prescribed to children under 5 years of age. However, with Zollinger-Ellison syndrome and some others acute diseases upper digestive tract, the doctor may prescribe Omeprazole. In this case, the dose of the drug is calculated based on the child’s body weight.1. For body weights up to 10 kg, the drug is prescribed at a dose of 5 mg per day.
2. With a weight of 10 to 20 kg, the daily dose of the drug is 10 mg.
3. If the child weighs 20 kg or more, a single dose of 20 mg of Omeprazole per day is allowed.
Omeprazole during pregnancy
Pregnancy is a contraindication for the use of Omeprazole. It is especially important to avoid taking the drug in the first trimester of pregnancy, because in this case, the risk of developing pathology increases sharply of cardio-vascular system in the fetus. During the remaining stages of pregnancy, Omeprazole is prescribed with great caution and only when positive effects from the drug outweigh the possible side effects.Omeprazole for gastritis
Omeprazole is prescribed only for gastritis with increased acidity! For normo- and hypoacid gastritis, Omeprazole is contraindicated and can provoke the development of atrophic gastritis with zero acidity of gastric juice. The maximum effect from a single dose of Omeprazole at a dose of 20 mg occurs on average after 1.5-2 hours. Therapeutic effect The drug lasts from 18 to 24 hours, so for gastritis the daily dose of Omeprazole is 1 capsule (20 mg). The duration of treatment usually does not exceed 2–3 weeks. During this time, the acidity of the stomach is normalized and the main symptoms of gastritis are eliminated.
If gastritis is associated with Helicobacter pylori infection, then along with Omeprazole it is necessary to carry out mandatory antibacterial treatment according to one of the generally accepted regimens in this case (triple therapy).
Omeprazole for heartburn
Omeprazole effectively eliminates heartburn symptoms during various diseases gastrointestinal tract. However, taking it independently is allowed only as an exception, as an emergency aid. Its dose in this case should not exceed 10 mg per day. Therapeutic effect from Omeprazole develops after 4-5 days, and the full course of treatment should not exceed 14 days. Treatment with Omeprazole can be repeated no earlier than after 4 months.If heartburn returns after treatment, you should consult a doctor for advice and examination. The same should be done for frequently recurring heartburn, especially if it occurs more than 2 days a week. In this case, appropriate treatment with Omeprazole in appropriate dosages will be prescribed.
Interaction of Omeprazole with other drugs
Omeprazole may alter the effects of any medicinal substance(Ketoconazole, Itraconazole, Ampicillin, iron salts, etc.), the activity and absorption of which depends on the pH of the stomach.Drugs that are transformed in the liver (Warfarin, Diazepam, Phenytoin, etc.) may, when interacting with Omeprazole, break down more slowly, increasing their concentration in the blood and tissues. Omeprazole also slows down the release of tranquilizers from the body (Sibazon, Diazepam, Elenium). In these cases, it may be necessary to reduce the data dose medicines.
Omeprazole may enhance the effect of indirect anticoagulants and anticonvulsants (coumarins, Diphenin). At simultaneous administration Clarithromycin and Omeprazole mutually enhance the effects.
Omeprazole enhances the negative effect of other drugs on the hematopoietic system.
Omeprazole analogues
Due to its popularity and high efficiency, Omeprazole has many analogues and generic drugs (synonyms), which contain the same main active ingredient, but differ significantly in price. The most popular analogues (synonyms) that are allowed in Russia:
- Bioprazole;
- Gastrozol;
- Omez;
- Omephesis;
- Ulzol;
- Omezol;
- Omeprazole-Acri;
- Omeprazole-Richter;
- Losek;
- Losek MAPS (pellets);
- Hasek.
- Hasek (Switzerland);
- Omeprazole-Astrapharm (Ukraine);
- Omeprazole-Darnitsa;
- Tserol (India).
Reviews about the drug
Lena, Novokamsk:"After giving birth, I often began to experience heartburn and nausea. I thought that this was a temporary phenomenon associated with the restructuring of the body, but time passed, and my condition only worsened. I went to the doctor for an examination and it turned out that I had GERD, biliary dyskinesia and duodenitis. Among other things, the doctor prescribed me Omeprazole. It helps me very quickly, literally in a matter of minutes it eliminates heartburn, and after 3-4 days almost all the symptoms go away. I tried taking other drugs - Lasek and Omefez, but only our domestic one worked Omeprazole is the only one that helps me best and does not give any side effects".
Victoria, Nizhnevartovsk:
“I had stomach problems since school, and when I went to college, it became even worse. Stomach pain, nausea, constant heartburn, problems with stool, naturally, problems with hair and skin... After another exacerbation, I came to V paid clinic, where my gastroenterologist prescribed a course of Helicobacter pylori treatment. I took antibiotics (amoxicillin and clarithromycin) and Omeprazole. The course of treatment was 4 weeks. As a result, I am very pleased with the results of the treatment, all the symptoms went away, Helicobacter was no longer detected in me. Thanks to the doctor who advised me this treatment regimen."
Pavel, Volgograd:
“I have such a job that I don’t really have time to eat during the day. As a result, I got gastritis with high acidity and some other kind of reflux. My wife brewed me all sorts of herbs for stomach pain, made porridge, but that’s not enough for me it became easier. When it really started to get worse, I went to the local doctor, she referred me for examinations, and then prescribed Omeprazole in capsules of 20 mg. I drank a capsule twice a day. After about a week I felt much better, and at the end of treatment, ". That is, after 2 months, I completely forgot about my sores. Once every six months I undergo preventive treatment with Omeprazole so that this reflux does not return and everything is fine, alive and well!"
Where to buy Omeprazole?
Considering that Omeprazole 20 mg is a prescription drug, it can only be purchased in a pharmacy chain.But even when Omeprazole is used in an over-the-counter dosage (10 mg in 1 capsule), it should be purchased only at licensed points of sale - in stationary or online pharmacies. For example, you can order Omeprazole on the Internet at Piluli.ru, at the online pharmacy for wholesale prices WER.RU, and at the IFK pharmacy. These pharmacies always have in stock this drug and operate throughout Russia.
Drug price
The price of Russian-made Omeprazole is low and affordable for any patient. Thus, Omeprazole in capsules of 20 mg, 14 pieces, costs on average 11-12 rubles, 28 capsules are sold for 16-20 rubles. The maximum price for domestic Omeprazole rarely exceeds 60 rubles per package. However, you need to remember that the price varies not only depending on the number of capsules or tablets in the package, but also greatly depends on the recognition of the manufacturer.
For example, the Indian analogue of Omeprazole - Omez 20 mg, 10 capsules costs from 65 rubles, and for the Indian Omez D in N30 capsules you need to pay 244 rubles. European analogues Losek Maps have a significantly higher cost - from 300 rubles and above. For drugs from some manufacturers you will have to pay from 1000 to 1500 rubles per package, which is usually enough for the entire course of treatment.
Analogues produced in former socialist countries have intermediate prices for the drug. Slovenian Omeprazole Sandoz 20 mg costs about 95 rubles for a package of 14 capsules, and for 28 capsules you need to pay about 140-150 rubles. Czech Helicid - 28 pcs./20 mg costs approximately 180 rubles.
The doctor must decide which of these drugs is preferable. Only he knows all the features of the action of Omeprazole and its analogues, so he can prescribe the most adequate drug that will affect maximum amount existing symptoms.
Before use, you should consult a specialist.pharmachologic effect
Omeprazole is an antiulcer drug, an inhibitor of the enzyme H + /K + -adenosine triphosphate (ATP) phase. Inhibits the activity of H + /K + - adenosine triphosphate (ATP phase (H + /K + -adenosine triphosphate (ATP) phase, also known as - " proton pump"or "proton pump") in the parietal cells of the stomach, thereby blocking the transfer of hydrogen ions and the final stage of hydrochloric acid synthesis in the stomach. Omeprazole is a prodrug. In the acidic environment of the parietal cell tubules, omeprazole is converted into the active metabolite sulfenamide, which inhibits membrane H + / K + - adenosine triphosphate (ATP) phase, connecting with it through a disulfide bridge. This explains the high selectivity of the action of omeprazole on parietal cells, where there is a medium for the formation of sulfenamide. The biotransformation of omeprazole into sulfenamide occurs quickly (within 2-4 minutes). Sulfenamide is a cation and is not absorbed.
Omeprazole suppresses basal and stimulated by any stimulus secretion of hydrochloric acid by final stage. Reduces the total volume of gastric secretion and inhibits the release of pepsin. Omeprazole has gastroprotective activity, the mechanism of which is not clear. Does not affect products internal factor Castle and the speed of transition of food mass from the stomach to the duodenum. Omeprazole does not act on acetylcholine and histamine receptors.
Omeprazole capsules contain film-coated microgranules, the gradual release and onset of action of omeprazole begins 1 hour after administration, reaches a maximum after 2 hours, and persists for 24 hours or more. Inhibition of 50% of maximum secretion after a single dose of 20 mg of the drug lasts 24 hours.
A single dose per day provides rapid and effective suppression of daytime and nighttime gastric secretion, reaching its maximum after 4 days of treatment. In patients with peptic ulcer duodenum Taking 20 mg of omeprazole maintains pH=3 inside the stomach for 17 hours. After stopping the drug, secretory activity is completely restored after 3-5 days.
Pharmacokinetics
Absorption is high. Bioavailability 30-40% (with liver failure increases almost to 100%), increases in elderly people and in patients with impaired liver function, insufficiency of renal function has no effect. TC max - 0.5-3.5 hours.
Possessing high lipophilicity, it easily penetrates the parietal cells of the stomach. Communication with plasma proteins is 90-95% (albumin and acidic alpha 1-glycoprotein).
T1/2 - 0.5-1 hour (for liver failure - 3 hours), clearance - 500-600 ml/min. Almost completely metabolized in the liver with the participation of the CYP2C19 enzyme system, with the formation of 6 pharmacologically inactive metabolites (hydroxyomeprazole, sulfide and sulfone derivatives, etc.). It is an inhibitor of the CYP2C19 isoenzyme. Excretion by the kidneys (70-80%) and bile (20-30%) in the form of metabolites.
In chronic renal failure, excretion decreases in proportion to the decrease in creatine clearance. In elderly patients, excretion decreases.
Indications
- peptic ulcer of the stomach and duodenum (in the acute phase and anti-relapse treatment), incl. associated with Helicobacter pylori (as part of combination therapy);
- reflux esophagitis (including erosive).
- hypersecretory conditions (Zollinger-Ellison syndrome, stress ulcers of the gastrointestinal tract, polyendocrine adenomatosis, systemic mastocytosis);
- gastropathy caused by taking non-steroidal anti-inflammatory drugs.
Dosage regimen
Orally, capsules are usually taken in the morning, without chewing, with a small amount of water (immediately before meals).
At exacerbation of peptic ulcer, reflux esophagitis and gastropathy caused by taking NSAIDs- 20 mg 1 time per day. Patients with severe course For reflux esophagitis, the dose is increased to 40 mg once a day. The course of treatment for duodenal ulcer is 2-4 weeks, if necessary - 4-5 weeks; for gastric ulcers, for reflux esophagitis, for erosive and ulcerative lesions of the gastrointestinal tract caused by taking NSAIDs - for 4-8 weeks.
Reduction of symptoms of the disease and scarring of the ulcer in most cases occurs within 2 weeks. For patients who do not experience complete scarring of the ulcer after a two-week course, treatment should be continued for another 2 weeks.
Patients resistant to treatment with other antiulcer drugs are prescribed 40 mg per day. The course of treatment for duodenal ulcer is 4 weeks, for gastric ulcer and reflux esophagitis - 8 weeks.
At Zollinger-Elisson syndrome- usually 60 mg 1 time per day; if necessary, the dose is increased to 80-120 mg/day (the dose is divided into 2 doses).
For prevention of relapse of peptic ulcer- 10 mg 1 time per day.
For eradication of Helicobacter pylori use “triple” therapy (within 1 week: omeprazole 20 mg, amoxicillin 1 g, clarithromycin 500 mg - 2 times a day; or omeprazole 20 mg, clarithromycin 250 mg, metronidazole 400 mg - 2 times a day; or omeprazole 40 mg once a day, amoxicillin 500 mg and metronidazole 400 mg - 3 times a day)
or “double” therapy (for 2 weeks: omeprazole 20-40 mg and amoxicillin 750 mg - 2 times a day or omeprazole 40 mg - 1 time a day and clarithromycin 500 mg - 3 times a day or amoxicillin 0.75-1.5 g -2 times a day).
At liver failure prescribed 10-20 mg 1 time per day (in case of severe liver failure, the daily dose should not exceed 20 mg); at renal dysfunction and at elderly patients
Side effect
From the digestive organs: diarrhea or constipation, abdominal pain, nausea, vomiting, flatulence; in rare cases - increased activity of liver enzymes, taste disturbances, in some cases - dry mouth, stomatitis, in patients with previous serious illness liver - hepatitis (including with jaundice), liver dysfunction.
From the nervous system: in patients with severe concomitant somatic diseases - headache, dizziness, agitation, depression, in patients with previous severe liver disease - encephalopathy.
From the musculoskeletal system: in some cases - arthralgia, myasthenia, myalgia.
From the hematopoietic system: in some cases - leukopenia, thrombocytopenia, agranulocytosis, pancytopenia.
From the outside skin: rarely - skin rash and/or itching, in some cases photosensitivity, multiform exudative erythema, alopecia.
Allergic reactions: urticaria, angioedema, fever, bronchospasm, interstitial nephritis and anaphylactic shock.
Others: rarely - visual disturbances, malaise, peripheral edema, increased sweating, gynecomastia, formation of gastric glandular cysts during long-term treatment(a consequence of inhibition of hydrochloric acid secretion, is benign, reversible).
Contraindications for use
— childhood;
- pregnancy;
- lactation period;
- hypersensitivity.
WITH caution: renal and/or liver failure.
Use during pregnancy and breastfeeding
Contraindicated during pregnancy and lactation.
Use in children
Contraindicated for children.
Overdose
Symptoms: confusion, blurred vision, drowsiness, dry mouth, nausea, tachycardia, arrhythmia, headache.
Treatment: symptomatic. Hemodialysis is not effective enough. There is no specific antidote.
Drug interactions
May reduce the absorption of ampicillin esters, iron salts, itraconazole and ketoconazole (omeprazole increases gastric pH).
Being inhibitors of cytochrome P450, it can increase the concentration and reduce the excretion of diazepam, indirect anticoagulants, phenytoin (drugs that are metabolized in the liver via cytochrome CYP2C19), which in some cases may require a reduction in the doses of these drugs. May increase plasma concentrations of clarithromycin.
At the same time, long-term use of omeprazole at a dose of 20 mg 1 time per day in combination with caffeine, theophylline, piroxicam, diclofenac, naproxen, metoprolol, propranolol, ethanol, cyclosporine, lidocaine, quinidine and estradiol did not lead to a change in their plasma concentrations.
Strengthens the inhibitory effect on the hematopoietic system and other drugs.
There was no interaction with concomitantly taken antacids.
Conditions for dispensing from pharmacies
On prescription.
Storage conditions and periods
List B. In a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children. Shelf life - 3 years.
Use for liver dysfunction
With caution: liver failure. At liver failure prescribed 10-20 mg 1 time per day (in case of severe liver failure, the daily dose should not exceed 20 mg);
Use for renal impairment
Carefully: renal failure. At renal dysfunction no dosage regimen adjustment is required.
Use in elderly patients
at elderly patients no dosage regimen adjustment is required.
special instructions
Before starting therapy, it is necessary to exclude the presence of a malignant process (especially with a stomach ulcer), since treatment, masking symptoms, can delay the correct diagnosis.
Taking it with food does not affect its effectiveness.
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Renata Ermakova
Omeprazole in this form, unfortunately, did not work. Maybe it came from an unscrupulous manufacturer, who knows. I also had to buy Rabelok and start treatment again. But more than 5 months have passed and my GERD is still silent. I even break my diet a little sometimes and it’s okay.
Zinaida
I have come across many medications in this life to get rid of heartburn. But so far the only one that fits perfectly for me is Rabelok. It acts faster and after monthly intake You don’t have to think about heartburn for at least half a year.
The drug is good, it eliminates heartburn for several days, but unfortunately, it does not eliminate the cause. You still need to find and eliminate the source of the problem. Otherwise, falling for temporary relief can lead to more serious problems.
I love to eat junk food, but after that I constantly have heartburn. To cope with it, I carry Omitox in my purse, effective remedy. I recommend. I like to eat junk food, but after that I always get heartburn. To cope with it, I carry Omitox, an effective remedy, in my purse. I recommend.
During my student years I got hooked on doshiki and other things. instant cooking. I got an ulcer like that. Afterwards I was treated for a long time and now I get heartburn. The doctor prescribed Omitox. Nice thing. I drank, and heartburn does not bother me. During my student years I got hooked on doshiki and other instant things. I got an ulcer like that. Afterwards I was treated for a long time and now I get heartburn. The doctor prescribed Omitox. Nice thing. I drank, and heartburn does not bother me.
I want to support those who have stomach ulcers. My uncle went through this disease and, fortunately, made a full recovery. Of course, I had to limit myself and undergo treatment for a long time. I was on omeprazole medications - this seems to be the most modern and safe standard of treatment. Specifically – Omitox. Unpleasant symptoms They pass very quickly, but don’t be fooled... I want to support those who have stomach ulcers. My uncle went through this disease and, fortunately, made a full recovery. Of course, I had to limit myself and undergo treatment for a long time. I was on omeprazole medications - this seems to be the most modern and safe standard of treatment. Specifically – Omitox. Unpleasant symptoms pass very quickly, but you should not be deceived - you need to continue treatment until complete healing. Has anyone had this experience?
I wish someone would give me the same advice that I am writing to you now: man, don’t waste your money and time on other medications - treat yourself with Omitox. I wish someone would give me the same advice that I am writing to you now: man, don’t waste your money and time on other medications - treat yourself with Omitox.