Panavir use. Panavir (solution for injection): instructions for use. Dosage and technique of injection therapy

Instructions for use

Panavir instructions for use

Dosage form

Solution for intravenous administration.

Compound

Panavir® (potato shoot extract) -0.04 mg/ml;

Excipients: sodium chloride - 0.045 g, water for injection - up to 5 ml.

Pharmacodynamics

Panavir® - purified extract of shoots of the Solanum tuberosum plant; the main active ingredient is a hexose glycoside consisting of glucose, rhamnose, arabinose, mannose, xylose, galactose, and uronic acids.

The drug Panavir® is an antiviral and immunomodulatory agent. Increases the body's nonspecific resistance to various infections and promotes the induction of alpha and gamma interferons by blood leukocytes.

In therapeutic doses, the drug is well tolerated.

Tests have shown the absence of mutagenic, teratogenic, carcinogenic, allergenic and embryotoxic effects. In preclinical studies on laboratory animals negative influence on reproductive function and fetal development has not been established.

Has anti-inflammatory properties in experimental models of exudative edema, chronic proliferative inflammation and in the pseudoallergic test inflammatory reaction on konkanavalin A.

An analgesic effect has been shown in models of neurogenic pain and pain caused by inflammatory process and thermal irritation.

Has an antipyretic effect.

In a model of parkinsonian syndrome caused by systemic administration of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, neuroprotective properties were shown.

Has the ability to improve the functions of the retina and optic nerve.

It has wound-healing properties in a gastric ulcer model.

Pharmacokinetics

At intravenous administration polysaccharides are detected in the blood within 5 minutes after administration and are captured by the cells of the reticuloendothelial system of the liver and spleen. Elimination begins quickly; after 20-30 minutes, polysaccharides are found in the urine and exhaled air.

Side effects

The drug is well tolerated possible complications may be associated with individual intolerance and hypersensitivity to the components of the drug.

However, if any unwanted side effects occur, you should stop administering the drug and consult your doctor.

If you notice any other side effects, not listed in the instructions, please inform your doctor.

Selling Features

prescription

Special conditions

When used in preparation for pregnancy, it helps reduce the frequency of reproductive losses due to cytomegalovirus and herpesvirus infections.

If the solution becomes cloudy, the drug is considered unsuitable for use.

INFLUENCE ON THE ABILITY TO DRIVE VEHICLES AND MECHANISMS

Opportunity Data negative influence drug on the ability to control vehicles and implementation potentially dangerous species activities requiring special attention and speed of psychomotor reactions are absent.

Indications

Herpesvirus infections various localizations(including recurrent genital herpes, herpes zoster and ophthalmic herpes).

Secondary immunodeficiency conditions against the background infectious diseases.

Cytomegalovirus infection, including in patients with recurrent miscarriage. Used in women with chronic viral infection and interferon deficiency during the preparation for pregnancy.

Human papillomavirus infection (anogenital warts) in the composition complex therapy.

Peptic ulcer stomach and duodenum in patients with long-term scarring ulcers and symptomatic ulcers of the gastroduodenal zone as part of complex therapy.

Tick-borne encephalitis in order to reduce the viral load and relieve neurological symptoms (anisoreflexia, decreased reflexes, pain at the exit points of cranial nerves, nystagmus) as part of complex therapy.

Rheumatoid arthritis, combined with herpesvirus infection in immunocompromised

Contraindications

Individual intolerance. Panavir® should not be used by patients who are allergic to the constituent components of the drug: glucose, mannose, rhamnose, arabinose, xylose.

Lactation period.

Childhood up to 12 years old.

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Mode of application

Dosage

Panavir® should be administered intravenously in a slow stream.

The therapeutic dose of the drug is 200 mcg active substance(contents of one ampoule or bottle).

For the treatment of herpes virus infections and tick-borne encephalitis, it is used twice with an interval of 48 or 24 hours. If necessary, the course of treatment can be repeated after 1 month.

For the treatment of gastric and duodenal ulcers in the acute phase and symptomatic ulcers of the gastroduodenal zone, 5 are used intravenous injections every other day for 10 days.

For the treatment of rheumatoid arthritis combined with herpesvirus infection in immunocompromised patients, 5 intravenous injections are used with an interval of 24-48 hours, if necessary, repeat the course after 2 months.

For the treatment of ARVI and influenza, 2 intravenous injections are used with an interval of 18-24 hours.

For the treatment of patients with chronic bacterial prostatitis, 5 intravenous injections are used with an interval of 48 hours.

APPLICATION IN PEDIATRICS

Panavir® is prescribed to children over 12 years of age at a dose of 100 mcg intravenously once a day.

For the treatment of herpes virus infections and tick-borne encephalitis, it is used twice with an interval of 48 or 24 hours. If necessary, the course of treatment can be repeated after 1 month.

For the treatment of cytomegalovirus and human papillomavirus infections, it is used three times during the first week with an interval of 48 hours and twice during the second week with an interval of 72 hours.

Thank you

The site provides background information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

Panavir represents Russian antiviral drug With wide range action, containing natural plant raw materials as active ingredients. The drug was created based on the discovery of Nobel Prize laureate N.N. Semenov about the powerful immunostimulating properties of biologically active substances contained in rapidly dividing cells of any plants.

The active component of Panavir has an antiviral and immunomodulatory effect, therefore it allows you to cure various diseases with short courses. Currently, Panavir is used in the treatment of herpes, papillomas, condylomas, tick-borne encephalitis, cytomegalovirus infection, including in pregnant women, as well as other infectious diseases caused by viruses or opportunistic bacteria.

Names, composition and release forms of Panavir

Currently, Panavir is available in the following dosage forms Oh:

Solution for intravenous administration;
Rectal suppositories (candles);
Vaginal suppositories (candles);
Gel for external and local application;
Gel spray Intim;
Gel spray Inlight.

Solution for intravenous administration, rectal and vaginal suppositories, as well as gel for external and local use are medicines produced in different forms under the same name: Panavir. Gel spray Intim and Inlight are a gel in a tube that can be sprayed like a regular aerosol spray. These gel sprays Intim and Inlight are not medicines, but belong to prophylactic agents, containing the same active ingredients as Panavir drugs, but in lower dosages. Panavir Intim and Inlight are often called simply sprays, suppositories - suppositories, a solution for intravenous use– ampoules. In the further text of the article we will also use these stable and understandable notations various forms drug Panavir.

As an active component, all dosage forms of Panavir contain purified extract from potato tops shoots (Solanum tuberosum). The main active ingredient of the extract is a complex saccharide consisting of glucose, rhamnose, arabinose, mannose, xylose, galactose and uronic acids. In principle, this extract from potato tops has a patented name Panavir, which gave the name to all forms of the drug.

Solution for intravenous administration, gel, rectal and vaginal suppositories Panavir as an active component contain 200 mcg of potato shoot extract in one ampoule or suppository. As auxiliary components, the solution for intravenous administration contains water and table salt, rectal suppositories - confectionery fat, paraffin and T2 emulsifier, vaginal suppositories - macrogol 1500 and 400, and gel for external and local use - glycerin, macrogol 400 and 4000, ethanol, sodium hydroxide, lanthanum nitrate hexahydrate and water.

Gel sprays Panavir Intim and Inlight have almost the same composition:

Polyethylene glycol;
Water;
Lantana nitrate;
Sodium hydroxide;
Castor oil;
Eucalyptus oil;
Potato shoot extract.

The differences between Intim and Inlight gel sprays lie in the area of application - the first is used to prevent infection of the genitals, and the second - in the oral cavity. Therefore, the two forms of the product have different attachments for ease of use, but otherwise are not fundamentally different from each other.

Therapeutic effects of Panavir

The therapeutic and pharmacological effects of Panavir are determined by the properties of the extract from potato shoots included in the drug. All dosage forms of the drug strengthen the nonspecific component of immunity and activate the production of interferon, which increases the human body's resistance to various viral and some bacterial infections. Thus, Panavir has the following therapeutic and pharmacological effects:

Immunomodulatory effect;
Antiviral effect;
Anti-inflammatory effect;
Analgesic effect;
Antipyretic effect;
Neuroprotective effect;
Wound healing effect.

The main therapeutic effects of all dosage forms of Panavir are immunomodulatory and antiviral. The anti-inflammatory effect is due to the immunomodulatory effect, due to which leukocytes and interferon synthesis are activated, and appears only in chronic and prolonged pathological process. Leukocytes enter the focus of a chronic inflammatory process, destroy pathogenic microbes in a short period of time, and interferons activate blood flow and promote complete removal decay products and toxins against the background of simultaneous tissue regeneration. Thus, the hearth chronic inflammation is quickly eliminated and the person recovers. Panavir effectively suppresses chronic inflammatory processes of an infectious or pseudo-allergic nature.

The analgesic effect of Panavir is due to the ability to stop inflammation and suppress pain impulses during temperature irritation, for example, burns, frostbite, etc.

Due to the suppression of inflammation, Panavir is able to moderately reduce body temperature.

Panavir reduces inflammation and damage nerve cells, increasing their resistance to the negative effects of factors environment. Thanks to this effect, the drug exhibits moderate neuroprotective properties, thanks to which it is able to improve the functioning of the retina and optic nerve.

For ulcerative defects of the gastric mucosa, Panavir is able to have a pronounced wound-healing effect, accelerating the process of restoring normal tissue structure.

Indications for use of Panavir solution, gel, suppositories and spray

Various dosage forms of Panavir are indicated for use in different states, because the delivery method active substance determines the maximum effectiveness for any specific diseases. The solution for intravenous administration has the widest range of indications for use, since this form of delivery of the active substance guarantees its penetration into all organs and tissues. The gel and suppositories have a narrower range of indications, since they are effective only for the treatment of diseases and symptoms manifested by damage to the skin and mucous membranes. And Intim and Inlight gel sprays have the narrowest range of indications for use, since they contain the lowest concentration of the active component.

Solution for intravenous administration Panavir

So, Panavir solution for intravenous administration is indicated for use for the following diseases:

Infections caused by various types herpes virus (for example, genital herpes, herpetic keratitis, chickenpox, herpes zoster, etc.);
Cytomegalovirus infection is primary or in the acute stage in the II or III trimesters of pregnancy;
Long-lasting and complexly cicatricial ulcers of the stomach and duodenum;
Tick-borne encephalitis (to eliminate the pathology of reflexes, nystagmus and pain in the areas where nerves exit the skull);
Viral dermatoses;
Rheumatoid arthritis in combination with herpes virus infection in people suffering from HIV/AIDS;
ARVI;
Flu;
Chronic bacterial prostatitis (as part of complex therapy).

Rectal suppositories Panavir

Panavir rectal suppositories are indicated for use in the following diseases:

Infections caused by various types of herpes virus (for example, genital herpes, herpetic keratitis, chickenpox, shingles, etc.);
Decreased immunity due to long-term or severe infectious diseases;
Cytomegalovirus infection, including women suffering from recurrent miscarriage;
Preparing for pregnancy in the presence of chronic viral infections;
Warts in the anus and genital area caused by human papillomavirus;
Tick-borne encephalitis (to eliminate the pathology of reflexes, nystagmus and pain in the areas where nerves exit the skull);
ARVI;
Flu.

Vaginal suppositories Panavir

Panavir vaginal suppositories are indicated for use only as part of complex therapy for genital herpes in women.

Gel for external and local use Panavir

Gel for external and local use Panavir is indicated for use in the treatment of infectious diseases. inflammatory diseases skin and mucous membranes (nose, mouth, throat, vagina, urethra, etc.) caused by Herpes simplex viruses 1 and 2. That is, the gel is used to treat herpetic rashes and blisters on the skin and mucous membranes.

Gel spray Intim Panavir

Gel-spray Intim Panavir is used to treat the external genitalia of both sexes and the vagina of women after intimacy. Gel spray reduces the risk of contracting various viral infections, and also promotes fast healing wounds and restoration of tissue integrity. That is, the indication for the use of Intim Panavir gel spray is the prevention of viral sexually transmitted infections and care of the intimate area.

Gel spray Inlight Panavir

Gel spray Inlight Panavir is used in the composition complex treatment influenza and acute respiratory viral infections, as well as to maintain the oral cavity in functional active state. Inlight Panavir is able to prevent infection with ARVI and influenza. That is, the indications for use of Inlight Panavir gel spray are the treatment and prevention of influenza and ARVI, as well as oral care.

Panavir - instructions for use

Each dosage form has its own rules and features of use, so we will consider the instructions for each of them separately.

Solution for intravenous administration Panavir (injections)

Panavir solution is injected into a vein slowly in a stream (by injection, not by dropper). For injection, the contents of the ampoule are transferred into a sterile syringe with a thin needle, and then slowly injected into the ulnar, subclavian or any other vein. The solution in the ampoule is ready for use; it does not need to be diluted or any other substances added. The drug can be administered at any time of the day.

Before using the solution, you must carefully examine it for turbidity. If any, even minimal, degree of turbidity of the solution is noted, then it cannot be used. Only a clear solution without any flakes or inclusions is suitable for use.

Single dose of Panavir for various diseases and states is 200 mcg of potato shoot extract, which corresponds to the contents of one ampoule - 5 ml of solution. That is, for one injection it is necessary to completely use one full ampoule of Panavir solution. The frequency of injections and duration of therapy with Panavir depend on the disease.

For the treatment of herpetic infections and elimination of symptoms of tick-borne encephalitis, Panavir is administered twice in one ampoule with an interval between injections of 24 or 48 hours. If necessary, the course of therapy can be repeated after one month.

For the treatment of cytomegalovirus infection (including during exacerbation in pregnant women) and papillomas on the genitals and anus, Panavir solution is administered according to the following scheme:
1. In the first week, one ampoule every other day (a total of three injections during the week);
2. In the second week, one ampoule every two days (a total of two injections during the week).

To speed up scarring ulcerative defects The mucous membrane of the stomach or duodenum requires five injections of Panavir, which are administered one ampoule every other day for 10 days.

Panavir gel is widely used for the treatment herpetic rashes on skin and mucous membranes of the oral cavity and nose in children of different ages. Most often, parents apply Panavir gel to herpes on the child’s lips or elements of chickenpox rash, so that they quickly go away, do not itch and do not cause a painful desire to scratch and pick off the scabs.

The intravenous solution is used only in children over 12 years of age. In this case, a single dosage of the solution for adolescents from 12 to 18 years old is 100 mcg of potato shoot extract, which is equivalent to 2.5 ml or half an ampoule. The solution can be administered to children 2.5 ml once a day. However, usually for the treatment of herpes and tick-borne encephalitis, children are administered half an ampoule of the solution every 1 or 2 days. If necessary, courses of therapy are repeated at monthly intervals. For the treatment of cytomegalovirus infection and papillomas, children are administered half an ampoule of Panavir solution according to the following scheme:

1. Half an ampoule of solution every other day for a week;
2. Half an ampoule of solution every two days during the second week.

Panavir Inlight gel spray is widely used in the complex therapy of viral inflammatory diseases of the throat, oral cavity, nose and pharynx in children. This spray is often called “children’s Panavir” precisely because wide application in pediatrics. So, the throat, mouth or nasal passages are treated with a spray to speed up recovery and relieve symptoms of a viral infection. Most often, Panavir Inlight spray is used for a runny nose, pharyngitis, viral tonsillitis and other inflammations of the ENT organs caused by ARVI, influenza, herpangina or other viral infections to which children are very susceptible.

Naturally, similar clinical trials for obvious ethical reasons, were not carried out on pregnant women, therefore, according to the existing international regulations on the preparation of instructions for medicines, the manufacturer must indicate that Panavir is contraindicated during pregnancy and breastfeeding.

But during the treatment of pregnant women who needed it for health reasons, it was found that the solution for intravenous administration is quite safe, since it does not have a negative effect on the fetus, and therefore can be used throughout the entire period of gestation. Therefore, the indications for use of Panavir solution indicate the treatment of cytomegalovirus, herpetic and other viral infections during pregnancy.

There are no similar data regarding rectal and vaginal suppositories, so they are prohibited for use during pregnancy.

Gel for external and local use Panavir can be used during pregnancy only if the expected benefit to the mother exceeds all possible risks for the fetus. This wording means that there have been no targeted studies of the safety of the gel for the fetus, but sufficient a large number of women used it during pregnancy and no fetal pathology was observed. That is, based on observations, the drug can be allowed to be used during pregnancy, but due to the lack of experimental data, this cannot be done according to international regulations. Under such circumstances, the manufacturer indicates in the instructions that the drug can be used if the risks are lower than the expected benefits. In practice, this means that Panavir gel has sufficient high level safety and can be used by pregnant women if necessary.

Panavir Intim and Inlight sprays can be used during pregnancy because, firstly, they contain a small amount of active substance, and secondly, observational data regarding the gel for external use can be extrapolated from them. And since the gel does not cause negative consequences for the fetus, then sprays containing less active substance are not able to adversely affect the growth and development of the embryo.

Side effects

Solution for intravenous administration, rectal and vaginal suppositories Panavir as adverse reactions can only cause hypersensitivity phenomena, for example, itching, rashes, redness of the skin, especially at the injection site. Gel for external use Panavir and sprays Intim and Inlight can also provoke itching and redness of the skin or mucous membrane, but only in those areas to which the drug was applied. These side effects of the gel and sprays quickly go away on their own without any treatment. In general, all forms of Panavir are well tolerated and very rarely cause any side effects.

Contraindications for use

All dosage forms of Panavir are contraindicated if serious illnesses kidneys, as well as individual intolerance or allergic reaction to glucose, mannose, rhamnose, arabinose, xylose or other components of the drugs. Panavir Intim and Inlight sprays have no other contraindications for use. And the solution, gel and suppositories have a number of contraindications, which are reflected in the table.

Panavir - analogues

On the pharmaceutical market of the CIS countries there are only analogue drugs of Panavir, which have similar therapeutic effects, but contain other active components. Moreover, drugs produced in the same forms can be considered analogues of various dosage forms of Panavir. For example, analogues of Panavir suppositories will be other suppositories, etc. Analogues of Panavir solution can be considered other solutions and lyophilisates for their preparation, as well as tablets or capsules for oral administration.

So, the following drugs are analogues of Panavir:

Allokin-alpha lyophilisate for the preparation of a solution for subcutaneous administration;
Alpizarin tablets;
Amizon tablets;
Amiksin tablets;
Arbidol capsules and tablets;
Armenicum concentrate for the preparation of solution for infusion;
Viracept powder and tablets for oral administration;
Hyporamine tablets and lyophilisate for the preparation of a solution for inhalation or nasal administration;
Groprinosin tablets;
Isoprinosine tablets;
Ingavirin capsules;
Isentress tablets;
Yodantipyrine tablets;
Kagocel tablets;
Lavomax tablets;
Liracept powder for oral administration;
Nikavir tablets;
ORVItol NP capsules;
Polyferon-CD4 tablets;
Proteflazid extract for oral and topical use;
Vaginal and rectal suppositories with hyporamin 0.05 g;
Tivicay tablets;
Tilaxin tablets;
Tiloron capsules and tablets;
Triazavirin capsules;
Ferrovir solution for intramuscular administration;
Fuzeon lyophilisate for the preparation of a solution for subcutaneous administration;
Celsentry tablets;
Ergoferon tablets.

Panavir (gel, suppositories, solution, Inlight and Intim sprays) - reviews

Most reviews of Panavir relate to the experience of using an intravenous solution and rectal or vaginal suppositories, which are used in the complex treatment of human papillomaviruses, herpes or cytomegalovirus. The reviews are contradictory - there are both positive and negative, enthusiastic and accusatory, etc. However, all reviews about Panavir are united by one thing - they are extremely emotional and filled not with analytical calculations, but with impressions and certain established ideas about the expected effect.

From this series, we can conditionally highlight positive reviews left by people who underwent treatment with Panavir and were able to achieve stable remission of viral infections, which is confirmed by the absence of viruses in the tests. In addition, people noted that in addition to this, Panavir increased immunity and for six months they did not suffer from any colds, ARVI or influenza.

Some negative reviews are due to the fact that people were unable to achieve remission and the disappearance of viruses from tests. In addition, there are negative reviews about Panavir, which were left by people who did not receive the expected effect and at the same time realized that they used the drug not according to indications, for example, to eliminate the human papillomavirus in tests, and not to reduce papillomas or

The last update of the description by the manufacturer was 08/26/2013

Filterable list

Active substance:

Compound

Description of the dosage form

clear or slightly opalescent, colorless or light brown liquid, odorless.

homogeneous mass white with a weak specific odor.

Rectal suppositories: white to white with a yellowish tint, cone-shaped or cylindrical in shape; The presence of yellowish-gray inclusions, odorless, is allowed.

Vaginal suppositories: cylindrical or cone-shaped, grayish-white, translucent.

pharmachologic effect

pharmachologic effect- immunomodulatory, antiviral.

Pharmacodynamics

Panavir ® - purified extract of plant shoots Solanum tuberosum; The main active ingredient is a hexose glycoside, consisting of glucose, rhamnose, arabinose, mannose, xylose, galactose, and uronic acids.

The drug Panavir ® is an antiviral and immunomodulatory agent. Increases the body's nonspecific resistance to various infections and promotes the induction of alpha and gamma interferons by blood leukocytes.

In therapeutic doses, the drug is well tolerated.

Tests have shown the absence of mutagenic, teratogenic, carcinogenic, allergenic and embryotoxic effects. In preclinical studies on laboratory animals, no negative effects on reproductive function and fetal development were established.

It has anti-inflammatory properties in experimental models of exudative edema, chronic proliferative inflammation and in the pseudoallergic inflammatory reaction test to concanavalin A.

An analgesic effect has been shown in models of neurogenic pain and pain caused by inflammation and thermal irritation.

Has an antipyretic effect.

In a model of parkinsonian syndrome caused by systemic administration of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, neuroprotective properties were shown.

Has the ability to improve the functions of the retina and optic nerve.

It has wound-healing properties in a gastric ulcer model.

Pharmacokinetics

. When administered intravenously, polysaccharides are detected in the blood within 5 minutes after administration and are captured by the cells of the reticuloendothelial system of the liver and spleen. Elimination begins quickly; after 20-30 minutes, polysaccharides are found in the urine and exhaled air.

Gel for external and local use, rectal suppositories, vaginal suppositories. The pharmacokinetics of these dosage forms of the drug have not been studied.

Indications of the drug Panavir ®

Solution for intravenous administration

cytomegalovirus infection, incl. in patients with recurrent miscarriage. Can be used in women with chronic viral infection and interferon deficiency in preparation for pregnancy;

peptic ulcer of the stomach and duodenum in patients with long-term non-scarring ulcers and symptomatic ulcers of the gastroduodenal zone - as part of complex therapy;

rheumatoid arthritis in combination with herpes virus infection in immunocompromised patients (to enhance the analgesic and anti-inflammatory effect of the main therapy) - as part of complex therapy;

ARVI and influenza - as part of complex therapy;

chronic bacterial prostatitis - as part of complex therapy.

Infectious and inflammatory diseases of the skin and/or mucous membranes caused by a virus herpes simplex Herpes simplex types I and II, incl. genital herpes.

Rectal suppositories

herpesvirus infections of various localizations, incl. recurrent genital herpes, herpes zoster and ophthalmic herpes;

secondary immunodeficiency states due to infectious diseases;

cytomegalovirus infection, incl. in patients with recurrent miscarriage. Used in women with chronic viral infection and interferon deficiency in preparation for pregnancy;

papillomavirus infection (anogenital warts) - as part of complex therapy;

tick-borne encephalitis - in order to reduce the viral load and relieve neurological symptoms (anisoreflexia, decreased reflexes, pain at the exit points of cranial nerves, nystagmus) - as part of complex therapy;

ARVI and influenza - as part of complex therapy.

Vaginal suppositories

genital herpes in women - as part of complex therapy.

Contraindications

Solution for intravenous administration

individual intolerance;

presence of allergies to the constituent components of the drug: glucose, mannose, rhamnose, arabinose, xylose;

lactation period;

children up to 12 years of age.

Gel for external and local use

individual intolerance and hypersensitivity to the components of the drug;

children under 18 years of age.

Rectal suppositories

hypersensitivity;

pregnancy;

lactation period;

childhood.

Vaginal suppositories

hypersensitivity to the components of the drug;

severe diseases of the kidneys and spleen;

pregnancy;

lactation period;

children under 18 years of age.

Use during pregnancy and breastfeeding

Solution for intravenous administration, gel for external and local use

Use during pregnancy is only possible if the expected benefit to the mother outweighs the potential risk to the fetus.

If necessary, use the drug during lactation breast-feeding During the period of use of the drug should be discontinued.

Rectal suppositories

If it is necessary to use the drug during lactation, breastfeeding should be stopped while using the drug.

Side effects

Solution for intravenous administration, rectal suppositories

The drug is well tolerated; possible complications may be associated with individual intolerance and hypersensitivity to the components of the drug.

Gel for external and local use

Rapid redness and itching of the skin and/or mucous membranes may occur in the area where the gel is applied.

Vaginal suppositories

In rare cases, allergic reactions are possible.

If any unwanted side effects occur or if other side effects not listed in the instructions are noticed, you should stop administering the drug and consult your doctor.

Interaction

Not registered.

Directions for use and doses

Solution for intravenous administration

IV jet slowly. The therapeutic dose of the drug is 200 mcg of active substance (contents of 1 amp. or 1 vial).

For the treatment of herpes virus infections and tick-borne encephalitis, it is used twice with an interval of 48 or 24 hours. If necessary, the course of treatment can be repeated after 1 month.

For the treatment of gastric and duodenal ulcers in the acute phase and symptomatic ulcers of the gastroduodenal zone, 5 IV injections are used every other day for 10 days.

For the treatment of rheumatoid arthritis in combination with herpesvirus infection in immunocompromised patients, 5 IV injections are used with an interval of 24-48 hours; if necessary, the course can be repeated after 2 months.

For the treatment of acute respiratory viral infections and influenza, 2 intravenous injections are used with an interval of 18-24 hours.

For the treatment of patients with chronic bacterial prostatitis, 5 intravenous injections are used with an interval of 48 hours.

Use in pediatrics: Panavir ® is prescribed to children over 12 years of age at a dose of 100 mcg IV once a day. For the treatment of herpes virus infections and tick-borne encephalitis, it is used twice with an interval of 48 or 24 hours. If necessary, the course of treatment can be repeated after 1 month. For the treatment of cytomegalovirus and human papillomavirus infections, it is used three times during the first week with an interval of 48 hours and twice during the second week with an interval of 72 hours.

Gel for external and local use

Externally and locally. The gel is applied in a thin layer to the affected areas of the skin and/or mucous membranes 5 times a day. The duration of treatment is 4-5 days. The course of treatment can be extended up to 10 days.

Rectal suppositories

Rectally. For the treatment of herpes virus infections and tick-borne encephalitis, use 1 supp. twice with an interval of 48 or 24 hours. If necessary, the course of treatment can be repeated after 1 month.

For the treatment of cytomegalovirus and human papillomavirus infections, 1 supp. three times during the first week with an interval of 48 hours and twice during the second week with an interval of 72 hours.

For the treatment of ARVI and influenza, 1 supp. at 24 hour intervals for 5 days.

Vaginal suppositories

Intravaginally. Insert into the vagina in the evening, as deep as possible, in a supine position with slightly bent legs, 1 vag daily for 5 days. supp. A repeated course of treatment is possible after consulting a doctor.

Overdose

No cases of overdose have been reported. The results of preclinical studies indicate low toxicity of the drug.

special instructions

Solution for intravenous administration: when used in preparation for pregnancy, it helps reduce the frequency of reproductive losses due to cytomegalovirus and herpesvirus infections.

If the solution becomes cloudy, the drug is considered unsuitable for use.

Gel for external and local use: It is recommended to start treatment at the earliest possible stage of the disease, at the first signs (itching, tingling, redness, feeling of tension), in this case the development of the vesicular stage of the disease can be completely prevented.

Panavir ® gel is not intended for use in ophthalmology. When applying the gel to the face, avoid getting it into the eyes.

Vaginal suppositories: To prevent urogenital reinfection, simultaneous treatment of sexual partners is necessary. If there is no effect, the diagnosis should be confirmed.

Effect on the ability to drive a car or perform work requiring increased speed physical and mental reactions. There is no data on the possibility of a negative effect of the drug on the ability to drive vehicles and carry out potentially hazardous activities that require special attention and speed of psychomotor reactions.

Release form

Solution for intravenous administration, 0.04 mg/ml. 5 ml of solution in ampoules or neutral glass bottles with a capacity of 5 ml, sealed with rubber stoppers with rolled aluminum caps.

2 or 5 ampoules in a blister pack, 1 blister pack of 2 or 5 ampoules, 2 blister packs of 5 ampoules each, along with an ampoule knife or scarifier in a cardboard pack.

When packaging in ampoules with a colored dot and a cut or a colored break ring on the ampoule, a scarifier or ampoule knife is not inserted.

2 or 5 bottles in a strip pack, 1 strip pack of 2 or 5 bottles, 2 strip packs of 5 bottles in a cardboard pack.

Gel for external and local use, 0.002%. 3, 5, 10 or 30 g of gel in an aluminum tube with an internal varnish coating. 1 tube in a cardboard pack.

Panavir is a herbal antiviral drug Russian-made, with a wide spectrum of action. Active substance – Polysaccharides of Solanum tuberosum shoots.

Antiviral agent– high molecular weight polysaccharide belonging to the class of hexose glycosides. Increases the body's nonspecific resistance to various infections and promotes the induction of interferon.

Studies prove the absence of embryotoxic, teratogenic, allergenic and carcinogenic effects. Preclinical studies on laboratory animals did not reveal any negative effects on reproductive function and prenatal development of the fetus.

Studies of a model of experimental exudative edema confirmed the presence of anti-inflammatory properties in the drug.

Panavir release form:

Rectal suppositories: from white with a yellowish tint to white, cylindrical or cone-shaped, odorless; The presence of yellowish-gray inclusions is allowed (in blister packs of 5 pcs., 1 or 2 packs in a cardboard box);
Vaginal suppositories: translucent, grayish-white, cylindrical or cone-shaped (in blister packs of 5 pcs., 1 pack in a cardboard box);
Gel for external and local use: white, homogeneous, has a slight specific odor (in aluminum tubes with an internal varnish coating of 3, 5, 10 or 30 g, 1 tube in a cardboard box);
Solution for intravenous (IV) administration: slightly opalescent or transparent, with a light brown tint or colorless, odorless (in neutral glass ampoules or bottles, sealed with rubber stoppers with rolled aluminum caps, 5 ml, 2 or 5 ampoules or vials in blister packs, 1 or 2 packs in a cardboard box (for ampoules - complete with or without an ampoule knife or scarifier)).

Indications for use

What does Panavir help with? According to the instructions, the drug is prescribed in the following cases:

Herpes (including herpes zoster, recurrent genital herpes, primary and recurrent herpetic lesions of the skin and mucous membranes, herpetic lesions of the eyes).
Papilloma (anogenital warts) – as part of complex therapy.
ARVI and influenza.
Chronic viral infections and conditions of interferon deficiency in women in preparation for pregnancy, cytomegalovirus in women with repeated miscarriages.
Secondary immunodeficiency conditions caused by infectious diseases.
Infectious and inflammatory diseases caused by bacteria, viruses and fungi (as a preventative and symptomatic remedy).
Chronic bacterial prostatitis - as part of complex therapy.
Tick-borne encephalitis - to relieve the viral load and eliminate neurological symptoms (as part of complex therapy).
Long-term non-scarring and symptomatic ulcers of the gastroduodenal zone in patients with gastric and duodenal ulcers - as part of complex therapy.
Rheumatoid arthritis combined with herpetic infection(in patients with immune deficiency).

Instructions for use of Panavir, dosage

Panavir gel is intended for external use. Apply a thin layer to the affected areas of the skin or mucous membranes 5 times during the day. The average course of treatment is 4-5 days, if necessary it can be extended to 10 days.

Intravaginally. A small amount of The gel is evenly distributed in a thin layer over the walls of the vagina. Treatment is continued until clinical manifestations disappear completely.

The drug is not intended for use by ophthalmologists; in case of accidental contact with the eyes, they should be rinsed with a significant volume of running water and consult a doctor.

Panavir injections

Injections of the solution are carried out intravenously, slowly, in a stream. The therapeutic dose is 200 mcg of the active substance, that is, a solution from one bottle or ampoule.

In the treatment of herpes virus infection and tick-borne encephalitis, 2 injections with an interval of 48 or 24 hours. If necessary, repeat the course after a month.
Human papillomavirus and cytomegalovirus infections - 3 injections of Panavir during the 1st week (interval is 48 hours) and 2 times during the 2nd week (interval is 72 hours).
In the treatment of rheumatoid arthritis, which is combined with herpes virus infection - 5 intravenous injections, the interval is 24-48 hours. The course is repeated after 2 months if necessary.
For influenza and ARVI, the instructions recommend 2 intravenous injections of Panavir with an interval of 18 to 24 hours.
For chronic bacterial prostatitis – 5 intravenous injections with an interval of 48 hours.

Vaginal suppositories should be inserted as deeply as possible (while lying on your back with your legs slightly bent).

Panavir suppositories are administered daily in a course of 5 days, 1 suppository. The doctor may prescribe a repeat treatment course.

Rectal suppositories

Application scheme:

Flu and acute respiratory viral infections: 5 suppositories with an interval of 24 hours;
Cytomegalovirus and human papillomavirus infections: first week – 3 suppositories with an interval of 48 hours, second week – 2 suppositories with an interval of 72 hours;
Herpesvirus infections and tick-borne encephalitis: 2 suppositories with an interval of 24 or 48 hours. After 30 days, the course can be repeated.

Side effects

The instructions warn about the possibility of developing the following side effects when prescribing Panavir:

Possible development allergic reactions, short-term redness and itching of the skin and/or mucous membranes.

Contraindications

It is contraindicated to prescribe Panavir solution in the following cases:

breastfeeding period;
child's age up to 12 years.

Contraindications when using the gel:

individual intolerance to the components of the drug;
age up to 18 years.

Rectal and vaginal suppositories:

individual intolerance to the components of the drug;
severe diseases of the spleen and kidneys;
pregnancy;
breastfeeding;
age up to 18 years.

Overdose

No cases of overdose have been reported. The results of preclinical studies indicate low toxicity of the drug.

Analogs of Panavir, price in pharmacies

If necessary, you can replace Panavir with an analogue therapeutic effect- these are drugs:

Yodantipyrine,
Detoxopyrol,
Ferroville.

For the gel – Gipferon.

By ATX code:

Actaviron,
Amizon,
Ingavir,

When choosing analogues, it is important to understand that instructions for use of Panavir, price and reviews of drugs similar action do not apply. It is important to consult a doctor and not change the drug yourself.

Price in Russian pharmacies: Panavir gel 0.002% 3 g - from 128 to 205 rubles, inlight oral spray 40 ml - from 280 rubles, Panavir 0.04 mg/ml injection solution 5 ml 5 ampoules - from 3790 rubles, according to 592 pharmacies .

Store in a dry place, protected from light, at a temperature of 2–25 °C. Shelf life – 3 years.

Intravenous solution and suppositories are available by prescription. Gel for external and local use - without a prescription.

Altfarm, LLC GREEN DUBRAVA Green Dubrava, CJSC Lanafarm LLC Moskhimfarmpreparaty FSUE im. Semashko Moskhimfarmpreparaty named after N.A. Semashko, OJSC Moskhimfarmpreparaty OJSC named after N.A. Semashko commissioned by ELLARA MC, LLC Ellara, LLC

Country of origin

Russia

Product group

Dermatological preparations

Antiviral agent plant origin

Release forms

5 - contour cell packaging (1) - cardboard packs 30g tube 3g tube 40ml tube 75 ml in cart. pack pack 2 ampoules of 5 ml pack 5 ampoules of 5 ml pack 5 sup bottle 40 ml bottle 40 ml bottle 40 ml individual/pack

Description of the dosage form

Solution for intravenous administration. gel Gel for external and local use Gel for external and local use 0.002% toothpaste Solution for intravenous administration spray oral spray spray/gel spray-gel Suppositories Vaginal Suppositories rectal

pharmachologic effect

The active ingredient of the Panavir Inlight gel is a biologically active heteroglycoside of plant origin (Panavir), obtained from rapidly dividing cells of the seedlings of the Solanum tuberosum plant and belonging to the class of high-molecular hexose glycosides. The biologically active heteroglycoside in combination with the gel base has a complex effect, which includes antiviral, bactericidal, immunomodulatory, anti-inflammatory, regenerating and protective. Gel Panavir Inlight has direct antiviral effect on different types DNA and RNA viruses: herpes zoster virus; herpes simplex viruses types 1 and 2; cytomegalovirus, Various types human papillomavirus, including oncogenic ones. Panavir Inlight gel prevents the penetration of viruses into cells, suppresses the synthesis of viral proteins, thereby preventing the replication of the virus. Panavir Inlight gel, due to its antiviral activity, significantly reduces the toxic load and has a cytoprotective effect, protecting cells from the effects of viruses. The protective effect of Panavir Inlight is due to a unique buffer base that contains lanthanum complex compounds. After application, Panavir Inlight is localized in the middle layers of the epidermis or mucous membrane and forms a voluminous molecular network with selective throughput. Molecules of water, oxygen and nitrogen pass freely, ensuring normal physiological functions skin and mucous membranes. At the same time, viruses, bacteria, fungi, spores of bacteria and fungi, high-molecular compounds are retained. The anti-inflammatory effect of Panavir Inlight is combined with a stimulating effect on humoral and cellular immunity factors. The buffer base of the gel blocks the spread of inflammatory factors and toxic substances, especially after insect bites. Thus, an antipruritic effect is achieved when using Panavir Inlight. The regenerating effect is manifested by the acceleration of the restoration of surface cells of the skin and mucous membranes.

Pharmacokinetics

When administered intravenously, polysaccharides are detected in the blood within 5 minutes after administration and are captured by the cells of the reticuloendothelial system of the liver and spleen. Elimination begins quickly; after 20-30 minutes, polysaccharides are found in the urine and exhaled air.

Special conditions

It is recommended to start treatment at the earliest possible stage of the disease, at the first signs (itching, tingling, redness, feeling of tension), in this case the development of the vesicular stage of the disease can be completely prevented. The drug Panavir ® is not intended for use in ophthalmology. When applying the gel to the face, avoid getting it in the eyes. INFLUENCE ON THE ABILITY TO DRIVE VEHICLES AND MECHANISMS There is no data on the possibility of a negative effect of the drug on the ability to drive vehicles and carry out potentially hazardous activities that require special attention and speed of psychomotor reactions.

Compound

potato shoot extract / panavir / 40 mcg panavir / shoot polysaccharides / 0.0002 g; Auxiliary ingredients: polyethylene oxide 1500, polyethylene oxide 400 Panavir ® (potato shoot extract) - 0.002 g; Excipients: glycerol - 30.00 g, macrogol 4000 - 15.00 g, macrogol 400 - 38.00 g, ethanol 95% - 1.00 g, sodium hydroxide - 0.40 g, lanthanum nitrate hexahydrate - 2.20 g, water - up to 100.00 g. Panavir ® (potato shoot extract) - 0.002 g; excipients: glycerol - 30.00 g, macrogol 4000 - 15.00 g, macrogol 400 - 38.00 g, ethanol 95% - 1.00 g, sodium hydroxide - 0.40 g, lanthanum nitrate hexahydrate - 2.20 g, water - up to 100.00 g. Panavir, calendula extract, silver citrate, d-panthenol, Panavir® (potato shoot extract) -0.04 mg/ml; excipients: sodium chloride - 0.045 g, water for injection - up to 5 ml. Panavir® (polysaccharides of Solanum tuberosum shoots) - 0.0002 g excipients: polyethylene oxide 1500 (macrogol 1500) - 1.2599 g, polyethylene oxide 400 (macrogol 400) - 0.1399 g. Panavir® (polysaccharides of Solanum tuberosum shoots) - 200 mcg excipients: confectionery fat or solid fat - 1.0198 g, paraffin - 0.0900 g, T-2 emulsifier - 0.0900 g. Suppository weight - 1.2 g. Polyethylene glycol, water, lanthanum nitrate, sodium hydroxide, polysaccharides of Solanum tuberosum shoots, PEG-40 hydrogenated Castor oil, eucalyptus oil. polyethylene glycol, water, lanthanum nitrate, sodium hydroxide, Solanum tuberosum shoot polysaccharides, PEG-40 hydrogenated castor oil, eucalyptus oil. Does not contain alcohol and hormones. polyethylene glycol, lanthanum salts, biologically active heteroglycoside, water Polyethylene glycol, lanthanum salts, biologically active heteroglycoside, water. Does not contain alcohol, dyes, aromatic or hormonal substances. pH - neutral. polyethylene glycol, sum of polysaccharides, lanthanum salts, water Polyethylene glycol, lanthanum nitrate, water, gatrium hydroxide, polysaccharides. potato shoot extract (panavir) 200 mcg

Panavir indications for use

Herpesvirus infections of various localizations (including recurrent genital herpes, herpes zoster and ophthalmic herpes). Secondary immunodeficiency states due to infectious diseases. Cytomegalovirus infection, including in patients with recurrent miscarriage. It is used in women with chronic viral infection and interferon deficiency in preparation for pregnancy. Human papillomavirus infection (anogenital warts) as part of complex therapy. Peptic ulcer of the stomach and duodenum in patients with long-term scarring ulcers and symptomatic ulcers of the gastroduodenal zone as part of complex therapy. Tick-borne encephalitis to reduce the viral load and relieve neurological symptoms (anisoreflexia, decreased reflexes, pain at exit points of cranial nerves, nystagmus) as part of complex therapy. Rheumatoid arthritis combined with herpesvirus infection in immunocompromised patients

Panavir contraindications

Individual intolerance. Panavir® should not be used by patients who are allergic to the constituent components of the drug: glucose, mannose, rhamnose, arabinose, xylose. Lactation period. Children's age up to 12 years.

Panavir dosage

0.002% 0.04 mg/ml 200 μg

Panavir side effects

The drug is well tolerated; possible complications may be associated with individual intolerance and hypersensitivity to the components of the drug. However, if any unwanted side effects occur, you should stop administering the drug and consult your doctor. If you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

No cases of overdose have been reported. The results of preclinical studies indicate low toxicity of the drug

Storage conditions

store in a dry place
keep away from children
store in a place protected from light

Information provided